                         SEQUENCE LISTING

<110>  OriGene Technologies Inc

<120>  Regulated Breast Cancer Genes 

<130>  3U 103 R1

<160>  148   

<170>  PatentIn version 3.1

<210>  1
<211>  2624
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (1)..(297)
<223>  

<400>  1
agc tca tct ctg ccg tgc tgc agg gaa ccc tat ttc ctt ccc ctg cag       48
Ser Ser Ser Leu Pro Cys Cys Arg Glu Pro Tyr Phe Leu Pro Leu Gln         
1               5                   10                  15              

ctc agc cac ctc ctc ctc tca ggt ctg cca gcc atg aaa ctt ctt tac       96
Leu Ser His Leu Leu Leu Ser Gly Leu Pro Ala Met Lys Leu Leu Tyr         
            20                  25                  30                  

ctg ttt ctt gcc atc ctt ctg gcc ata gaa gaa cca gtg ata tca ggt      144
Leu Phe Leu Ala Ile Leu Leu Ala Ile Glu Glu Pro Val Ile Ser Gly         
        35                  40                  45                      

aac gtg agc ctc tct cgg ggg tct ggg ttc ctg gtc atg ggc ttc ccg      192
Asn Val Ser Leu Ser Arg Gly Ser Gly Phe Leu Val Met Gly Phe Pro         
    50                  55                  60                          

tct ttc cct tcc ctc tca ctg tgg gca tca tct gaa gcc ttt cct tct      240
Ser Phe Pro Ser Leu Ser Leu Trp Ala Ser Ser Glu Ala Phe Pro Ser         
65                  70                  75                  80          

ctc ctg cag ctt cgg gag gtt tgc cca gga tca tct caa gtt aat atc      288
Leu Leu Gln Leu Arg Glu Val Cys Pro Gly Ser Ser Gln Val Asn Ile         
                85                  90                  95              

tct ctc tga ttcttttttg ccagagtggt gggatgatag atgtttggag              337
Ser Leu                                                                 
                                                                        

catctggtgc ttgagggcca gggtggtatc ctggtgggag cttgggagag gtttgagggg    397

caaagcgtgg gtgcaggttg gggacttgtt gaggacttcg ggagactaga gtggaagctg    457

gggtgagttg tgatgtggag gaaaaacctt gggattggag tgatagaagg aatattagga    517

tgagctggag gtgaggagct gggcttccct gatggtttag ggcagagttg gagacaggat    577

gggatttggg gttgagtgga gctggtgttg aggattaggc tggggcttgg gctgaggctg    637

ggagtcggtg ctggatgctg cagggtgatt gggttcagct tggtcatggc atactgctgg    697

gaattgaggt tagtgacttg attagattag ggttagatta gattagatta gggtttggct    757

tggagttggg gcttgggggc attgagttga gtaaggctgg gagttctaat taaggcaggc    817

ctgaatgagt ttgagtttga attgggttaa tatagggtca aggaagattg cagattggga    877

tgcggctgga gctgaggctt gttgggctta tgtgaaatag ggtcaggtta ttgataagaa    937

acagggtctg tgtaatgtga gtgaatcctc ttcgttccct aatattacag gtgatcatgt    997

ccttttccct tcatccctag ctctgctagg tgggacatta attagcttca gttgattcca   1057

aagtaaggag taggaagttg ggggatagga agacagaagg gtgagaagtc caaaaaaggc   1117

tctcccaaaa acttcggagc tctcagttgg aaccattgtc tcagttctct tccctctcaa   1177

ggtctcttct ctcttttcct gggactgggt ctggtattac tcactcagct ggctttcttc   1237

tcttcttccc tgtcctcctg ttcctcctct gccttgtctt ttctctccgc ttgagggata   1297

ctaacatctg cttaattgtt gttcatatgc cccaaagtag agtgttggat ggatggacac   1357

tgccggttgt tgtgcaaaga tggtgaagac agcatcatac gctgccgaaa tcgtaaacgg   1417

tgctgtgttc ctagtcgtta tttaacaatc caaccagtaa caattcatgg aatccttggc   1477

tggaccactc ctcagatgtc cacaacagct ccaaaaatga agacaaatat aactaataga   1537

tagaaatgac tttgtttcag gttgcttagg gtccacattt cattaaaact cacaaatttg   1597

tttctggtgt ctgtcaatca taaggaatga tacttcaaat ggattgaggg tggggggatg   1657

gcagggggag gtgaagagct agtcgagaga agtcactagg gctgggtcat agcgatggtg   1717

tgatcattac agtcttgaag atgattcccc atctaccagc tgcaggagag gctattgagt   1777

caggagtgga ctggggagaa catggtggga gctgagagat ttaaaggcat agcagatgcc   1837

taaagagtgg gagaatcctt aggctgggag agttggtcca tcttgagagt gaatgggctg   1897

agagtggatg gggctgaata taacccaaat ccttggggtt ctagagaaac cagctgatgc   1957

tttctagtgc tcaagaggcc cagccccagg ggttagaagg tgtctaagta ctaaaaaaag   2017

ataaagcaca tgatttgctt atttatatat gaatttgttc attattcatt ttttccattc   2077

tttcaccgat tcattcattc atattcactt cagctctgcc acttactact ggcagactct   2137

gcatataaac ctctcagaac ttcatcttcc tcctctgtaa attagagtaa ttgtagaatc   2197

tatttcagga ttgcagtaag gatgaaatga cataataatg caaagctctg gtgaggacag   2257

tgggatgctg cctggatact gccaggcaaa cgccacatcc ttcgatgcat gggtaacagt   2317

ggaatttgta gggcctcttg caaaaagaac gaacagccct acctctattg cagaaattgt   2377

cagtcctgct gcctccagtc ctacatgagg ataagcattt ctggcaaaga ggaaaatacc   2437

gactggtctt atgagaagca gtggccaaga ctaccttgag tgctggtgat taccattctc   2497

aagctctctg ggcgcagaga cctgctgtca acccccctca ttaaaattca tgtgcctgct   2557

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2617

aaaaaaa                                                             2624


<210>  2
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Ser Ser Leu Pro Cys Cys Arg Glu Pro Tyr Phe Leu Pro Leu Gln 
1               5                   10                  15      


Leu Ser His Leu Leu Leu Ser Gly Leu Pro Ala Met Lys Leu Leu Tyr 
            20                  25                  30          


Leu Phe Leu Ala Ile Leu Leu Ala Ile Glu Glu Pro Val Ile Ser Gly 
        35                  40                  45              


Asn Val Ser Leu Ser Arg Gly Ser Gly Phe Leu Val Met Gly Phe Pro 
    50                  55                  60                  


Ser Phe Pro Ser Leu Ser Leu Trp Ala Ser Ser Glu Ala Phe Pro Ser 
65                  70                  75                  80  


Leu Leu Gln Leu Arg Glu Val Cys Pro Gly Ser Ser Gln Val Asn Ile 
                85                  90                  95      


Ser Leu 
        


<210>  3
<211>  429
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (3)..(341)
<223>  

<400>  3
ag caa agc tca tct ctg ccg tgc tgc agg gaa ccc tat ttc ctt ccc        47
   Gln Ser Ser Ser Leu Pro Cys Cys Arg Glu Pro Tyr Phe Leu Pro          
   1               5                   10                  15           

ctg cag ctc agc cac ctc ctc ctc tca ggt ctg cca gcc atg aaa ctt       95
Leu Gln Leu Ser His Leu Leu Leu Ser Gly Leu Pro Ala Met Lys Leu         
                20                  25                  30              

ctt tac ctg ttt ctt gcc atc ctt ctg gcc ata gaa gaa cca gtg ata      143
Leu Tyr Leu Phe Leu Ala Ile Leu Leu Ala Ile Glu Glu Pro Val Ile         
            35                  40                  45                  

tca ggc aaa cgc cac atc ctt cga tgc atg ggt aac agt gga att tgt      191
Ser Gly Lys Arg His Ile Leu Arg Cys Met Gly Asn Ser Gly Ile Cys         
        50                  55                  60                      

agg gcc tct tgc aaa aag aac gaa cag ccc tac ctc tat tgc aga aat      239
Arg Ala Ser Cys Lys Lys Asn Glu Gln Pro Tyr Leu Tyr Cys Arg Asn         
    65                  70                  75                          

tgt cag tcc tgc tgc ctc cag tcc tac atg agg ata agc att tct ggc      287
Cys Gln Ser Cys Cys Leu Gln Ser Tyr Met Arg Ile Ser Ile Ser Gly         
80                  85                  90                  95          

aaa gag gaa aat acc gac tgg tct tat gag aag cag tgg cca aga cta      335
Lys Glu Glu Asn Thr Asp Trp Ser Tyr Glu Lys Gln Trp Pro Arg Leu         
                100                 105                 110             

cct tga gtgctggtga ttaccattct caagctctct gggcgcagag acctgctgtc       391
Pro                                                                     
                                                                        

aacccccctc attaaaattc atgtgcctgc taaaaaaa                            429


<210>  4
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Ser Ser Ser Leu Pro Cys Cys Arg Glu Pro Tyr Phe Leu Pro Leu 
1               5                   10                  15      


Gln Leu Ser His Leu Leu Leu Ser Gly Leu Pro Ala Met Lys Leu Leu 
            20                  25                  30          


Tyr Leu Phe Leu Ala Ile Leu Leu Ala Ile Glu Glu Pro Val Ile Ser 
        35                  40                  45              


Gly Lys Arg His Ile Leu Arg Cys Met Gly Asn Ser Gly Ile Cys Arg 
    50                  55                  60                  


Ala Ser Cys Lys Lys Asn Glu Gln Pro Tyr Leu Tyr Cys Arg Asn Cys 
65                  70                  75                  80  


Gln Ser Cys Cys Leu Gln Ser Tyr Met Arg Ile Ser Ile Ser Gly Lys 
                85                  90                  95      


Glu Glu Asn Thr Asp Trp Ser Tyr Glu Lys Gln Trp Pro Arg Leu Pro 
            100                 105                 110         


<210>  5
<211>  503
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (3)..(335)
<223>  

<400>  5
ag cgg ccc gca gcc ctg ctg ata aaa gca aag ctc atc tct gcc gtg        47
   Arg Pro Ala Ala Leu Leu Ile Lys Ala Lys Leu Ile Ser Ala Val          
   1               5                   10                  15           

ctg cag gga acc cta ttt cct tcc cct gca gct cag cca cct cct cct       95
Leu Gln Gly Thr Leu Phe Pro Ser Pro Ala Ala Gln Pro Pro Pro Pro         
                20                  25                  30              

ctc agg tct gcc agc cat gaa act tct tta cct gtt tct tgc cat cct      143
Leu Arg Ser Ala Ser His Glu Thr Ser Leu Pro Val Ser Cys His Pro         
            35                  40                  45                  

tct ggc cat aga aga acc agt gat atc agc tct ggt gag gac agt ggg      191
Ser Gly His Arg Arg Thr Ser Asp Ile Ser Ser Gly Glu Asp Ser Gly         
        50                  55                  60                      

atg ctg cct gga tac tgc cag gca aac gcc aca tcc ttc gat gca tgg      239
Met Leu Pro Gly Tyr Cys Gln Ala Asn Ala Thr Ser Phe Asp Ala Trp         
    65                  70                  75                          

gta aca gtg gaa ttt gta ggg cct ctt gca aaa aga acg aac agc cct      287
Val Thr Val Glu Phe Val Gly Pro Leu Ala Lys Arg Thr Asn Ser Pro         
80                  85                  90                  95          

acc tct att gca gaa att gtc agt cct gct gcc tcc agt cct aca tga      335
Thr Ser Ile Ala Glu Ile Val Ser Pro Ala Ala Ser Ser Pro Thr             
                100                 105                 110             

ggataagcat ttctggcaaa gaggaaaata ccgactggtc ttatgagaag cagtggccaa    395

gactaccttg agtgctggtg attaccattc tcaagctctc tgggcgcaga gacctgctgt    455

caacccccct cattaaaatt catgtgcctg ctaaaaaaaa aaaaaaaa                 503


<210>  6
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Pro Ala Ala Leu Leu Ile Lys Ala Lys Leu Ile Ser Ala Val Leu 
1               5                   10                  15      


Gln Gly Thr Leu Phe Pro Ser Pro Ala Ala Gln Pro Pro Pro Pro Leu 
            20                  25                  30          


Arg Ser Ala Ser His Glu Thr Ser Leu Pro Val Ser Cys His Pro Ser 
        35                  40                  45              


Gly His Arg Arg Thr Ser Asp Ile Ser Ser Gly Glu Asp Ser Gly Met 
    50                  55                  60                  


Leu Pro Gly Tyr Cys Gln Ala Asn Ala Thr Ser Phe Asp Ala Trp Val 
65                  70                  75                  80  


Thr Val Glu Phe Val Gly Pro Leu Ala Lys Arg Thr Asn Ser Pro Thr 
                85                  90                  95      


Ser Ile Ala Glu Ile Val Ser Pro Ala Ala Ser Ser Pro Thr 
            100                 105                 110 


<210>  7
<211>  1422
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (66)..(1280)
<223>  

<400>  7
ttttttaaga ctcatggaca tagctttaat tatctttgcc tgacgcccaa tacctgaaaa     60

ttaag atg ttc atg caa gat aaa gag gta att ttt ctc ctc ctc cca gtc    110
      Met Phe Met Gln Asp Lys Glu Val Ile Phe Leu Leu Leu Pro Val       
      1               5                   10                  15        

atc acc cgt agc atc cgg tta aga ggc tct cca cct cgc tca ttt tgg      158
Ile Thr Arg Ser Ile Arg Leu Arg Gly Ser Pro Pro Arg Ser Phe Trp         
                20                  25                  30              

tct aac tgg att tac aca aac tca ctg tgc acg tgc ctg ggg cgg gca      206
Ser Asn Trp Ile Tyr Thr Asn Ser Leu Cys Thr Cys Leu Gly Arg Ala         
            35                  40                  45                  

aac ccg gaa acg acg ccg agt ccc gcg gga tcc agg agg agc caa ctg      254
Asn Pro Glu Thr Thr Pro Ser Pro Ala Gly Ser Arg Arg Ser Gln Leu         
        50                  55                  60                      

cgc cgg agg agg ggt ttc ggc cga cac gtc ggg att ggc ggc tgc agc      302
Arg Arg Arg Arg Gly Phe Gly Arg His Val Gly Ile Gly Gly Cys Ser         
    65                  70                  75                          

cag ggt cct ccg acg ctg ggc ttc cgt gag cgg cgc tct gcc aga tct      350
Gln Gly Pro Pro Thr Leu Gly Phe Arg Glu Arg Arg Ser Ala Arg Ser         
80                  85                  90                  95          

ctg gac cgg att cgt ccc att ctc gtc ctc atg gtg gac aag aaa ctg      398
Leu Asp Arg Ile Arg Pro Ile Leu Val Leu Met Val Asp Lys Lys Leu         
                100                 105                 110             

gtg gtg gtt ttc gga ggc aca ggt gcc cag ggt ggc tcc gtg gcc cgc      446
Val Val Val Phe Gly Gly Thr Gly Ala Gln Gly Gly Ser Val Ala Arg         
            115                 120                 125                 

aca ctc ctg gaa gat ggg aca ttc aag gtt cga gtg gtg acc cga aac      494
Thr Leu Leu Glu Asp Gly Thr Phe Lys Val Arg Val Val Thr Arg Asn         
        130                 135                 140                     

cct agg aag aag gca gca aag gag ctg agg ctg caa ggt gca gaa gta      542
Pro Arg Lys Lys Ala Ala Lys Glu Leu Arg Leu Gln Gly Ala Glu Val         
    145                 150                 155                         

gtg cag gga gac caa gat gac cag gtc atc atg gag ctg gcc ctg aat      590
Val Gln Gly Asp Gln Asp Asp Gln Val Ile Met Glu Leu Ala Leu Asn         
160                 165                 170                 175         

ggg gct tac gcc acc ttc atc gtg acc aat tac tgg gag agc tgc agc      638
Gly Ala Tyr Ala Thr Phe Ile Val Thr Asn Tyr Trp Glu Ser Cys Ser         
                180                 185                 190             

cag gag cag gag gtc aag cag ggg aag ctg ctc gct gat ctg gcc agg      686
Gln Glu Gln Glu Val Lys Gln Gly Lys Leu Leu Ala Asp Leu Ala Arg         
            195                 200                 205                 

cgc ctg ggc ctc cac tat gtg gtc tac agc ggc ctg gag aac atc aag      734
Arg Leu Gly Leu His Tyr Val Val Tyr Ser Gly Leu Glu Asn Ile Lys         
        210                 215                 220                     

aag ctg acg gca ggg aga ttg gcc gcc gcg cac ttt gac ggc aaa ggg      782
Lys Leu Thr Ala Gly Arg Leu Ala Ala Ala His Phe Asp Gly Lys Gly         
    225                 230                 235                         

gag gtg gag gaa tat ttc cgg gac att ggc gtt ccc atg acc agt gtg      830
Glu Val Glu Glu Tyr Phe Arg Asp Ile Gly Val Pro Met Thr Ser Val         
240                 245                 250                 255         

cgg ctg ccc tgc tat ttt gag aac ctc ctc tcc cac ttc ttg ccc cag      878
Arg Leu Pro Cys Tyr Phe Glu Asn Leu Leu Ser His Phe Leu Pro Gln         
                260                 265                 270             

aaa gcc cca gac gga aag agc tac ttg ctg agc ttg ccc aca ggt gac      926
Lys Ala Pro Asp Gly Lys Ser Tyr Leu Leu Ser Leu Pro Thr Gly Asp         
            275                 280                 285                 

gtt ccc atg gat ggc atg tcc gtg tct gac ctg ggt cct gtg gtg ctc      974
Val Pro Met Asp Gly Met Ser Val Ser Asp Leu Gly Pro Val Val Leu         
        290                 295                 300                     

agc ctt ttg aag atg cca gaa aaa tac gtc ggc cag aac atc ggg ctg     1022
Ser Leu Leu Lys Met Pro Glu Lys Tyr Val Gly Gln Asn Ile Gly Leu         
    305                 310                 315                         

agc act tgc agg cac acg gcc gag gag tac gct gcc ctg ctc acc aag     1070
Ser Thr Cys Arg His Thr Ala Glu Glu Tyr Ala Ala Leu Leu Thr Lys         
320                 325                 330                 335         

cac acc cgc aag gtc gtg cac gat gcc aag atg act cct gag gac tac     1118
His Thr Arg Lys Val Val His Asp Ala Lys Met Thr Pro Glu Asp Tyr         
                340                 345                 350             

gaa aag ctt ggc ttt ccc ggt gcc cgg gac ctg gcc aac atg ttc cgt     1166
Glu Lys Leu Gly Phe Pro Gly Ala Arg Asp Leu Ala Asn Met Phe Arg         
            355                 360                 365                 

ttc tat gcc ctg aga ccc gac cgt gac atc gag ctg acc ctg aga ctc     1214
Phe Tyr Ala Leu Arg Pro Asp Arg Asp Ile Glu Leu Thr Leu Arg Leu         
        370                 375                 380                     

aac ccc aag gcc ctg acg ctg gac cag tgg ctg gaa cag cac aaa ggg     1262
Asn Pro Lys Ala Leu Thr Leu Asp Gln Trp Leu Glu Gln His Lys Gly         
    385                 390                 395                         

gac ttc aac ctg ctg tga cctgcccgcc tcgcggcccc ttgtggggat            1310
Asp Phe Asn Leu Leu                                                     
400                                                                     

cgggggcacc agaggggcag aggcaccaac atctgaataa agccattgtt ctcccaaaaa   1370

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa           1422


<210>  8
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Phe Met Gln Asp Lys Glu Val Ile Phe Leu Leu Leu Pro Val Ile 
1               5                   10                  15      


Thr Arg Ser Ile Arg Leu Arg Gly Ser Pro Pro Arg Ser Phe Trp Ser 
            20                  25                  30          


Asn Trp Ile Tyr Thr Asn Ser Leu Cys Thr Cys Leu Gly Arg Ala Asn 
        35                  40                  45              


Pro Glu Thr Thr Pro Ser Pro Ala Gly Ser Arg Arg Ser Gln Leu Arg 
    50                  55                  60                  


Arg Arg Arg Gly Phe Gly Arg His Val Gly Ile Gly Gly Cys Ser Gln 
65                  70                  75                  80  


Gly Pro Pro Thr Leu Gly Phe Arg Glu Arg Arg Ser Ala Arg Ser Leu 
                85                  90                  95      


Asp Arg Ile Arg Pro Ile Leu Val Leu Met Val Asp Lys Lys Leu Val 
            100                 105                 110         


Val Val Phe Gly Gly Thr Gly Ala Gln Gly Gly Ser Val Ala Arg Thr 
        115                 120                 125             


Leu Leu Glu Asp Gly Thr Phe Lys Val Arg Val Val Thr Arg Asn Pro 
    130                 135                 140                 


Arg Lys Lys Ala Ala Lys Glu Leu Arg Leu Gln Gly Ala Glu Val Val 
145                 150                 155                 160 


Gln Gly Asp Gln Asp Asp Gln Val Ile Met Glu Leu Ala Leu Asn Gly 
                165                 170                 175     


Ala Tyr Ala Thr Phe Ile Val Thr Asn Tyr Trp Glu Ser Cys Ser Gln 
            180                 185                 190         


Glu Gln Glu Val Lys Gln Gly Lys Leu Leu Ala Asp Leu Ala Arg Arg 
        195                 200                 205             


Leu Gly Leu His Tyr Val Val Tyr Ser Gly Leu Glu Asn Ile Lys Lys 
    210                 215                 220                 


Leu Thr Ala Gly Arg Leu Ala Ala Ala His Phe Asp Gly Lys Gly Glu 
225                 230                 235                 240 


Val Glu Glu Tyr Phe Arg Asp Ile Gly Val Pro Met Thr Ser Val Arg 
                245                 250                 255     


Leu Pro Cys Tyr Phe Glu Asn Leu Leu Ser His Phe Leu Pro Gln Lys 
            260                 265                 270         


Ala Pro Asp Gly Lys Ser Tyr Leu Leu Ser Leu Pro Thr Gly Asp Val 
        275                 280                 285             


Pro Met Asp Gly Met Ser Val Ser Asp Leu Gly Pro Val Val Leu Ser 
    290                 295                 300                 


Leu Leu Lys Met Pro Glu Lys Tyr Val Gly Gln Asn Ile Gly Leu Ser 
305                 310                 315                 320 


Thr Cys Arg His Thr Ala Glu Glu Tyr Ala Ala Leu Leu Thr Lys His 
                325                 330                 335     


Thr Arg Lys Val Val His Asp Ala Lys Met Thr Pro Glu Asp Tyr Glu 
            340                 345                 350         


Lys Leu Gly Phe Pro Gly Ala Arg Asp Leu Ala Asn Met Phe Arg Phe 
        355                 360                 365             


Tyr Ala Leu Arg Pro Asp Arg Asp Ile Glu Leu Thr Leu Arg Leu Asn 
    370                 375                 380                 


Pro Lys Ala Leu Thr Leu Asp Gln Trp Leu Glu Gln His Lys Gly Asp 
385                 390                 395                 400 


Phe Asn Leu Leu 
                


<210>  9
<211>  4909
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (540)..(1226)
<223>  

<400>  9
ctctcccctc ccttgcgttg cccccctctc ccgccgcctc ctcccgctct cctctcgctc     60

tcctcccgcc tccttcttcc aggcgcggcc agcgggggca agagcgaggt ggctgcgagg    120

aggcgtcact gaaagccctg acttggggaa ggctgcgggc tcggagccgg agacgccgag    180

ctggggccgg gtgagttggg aatcagactc ttgagttgac agctggccta tggtttctgc    240

attttgttaa gaagcacctc atgcaagcga gggacctggg actgctcaca gccaggtggc    300

atttttctga agttgttcat taagacttcc cagcattcct acagatataa ataggtgagg    360

ccgcaggcgg tgctctgggt ccgggagcgc tgtccccagc atgaacgcgg ccggcggcgg    420

gagtgaatga ctgcagctgc gacttccttc ccgggccgcc cgagcctcct tccccaccga    480

ctttcttgtt ttgattaact ccgtggactc ctgactcttt cttcgcccgg aacatcaat     539

atg tgt cat gtc att gtc acc tgt cgc tcg atg ctc tgg acc ttg ctg      587
Met Cys His Val Ile Val Thr Cys Arg Ser Met Leu Trp Thr Leu Leu         
1               5                   10                  15              

agt att gtg gtg gct ttt gcc gag ctc att gcc ttc atg agt gca gac      635
Ser Ile Val Val Ala Phe Ala Glu Leu Ile Ala Phe Met Ser Ala Asp         
            20                  25                  30                  

tgg ctg atc ggg aaa gcg agg agc cgc ggc ggc gtg gag ccg gcg ggc      683
Trp Leu Ile Gly Lys Ala Arg Ser Arg Gly Gly Val Glu Pro Ala Gly         
        35                  40                  45                      

ccg ggc ggg ggc tcc ccg gag ccc tac cac ccc acc ctg ggc atc tac      731
Pro Gly Gly Gly Ser Pro Glu Pro Tyr His Pro Thr Leu Gly Ile Tyr         
    50                  55                  60                          

gcc cgc tgc atc cgg aac cca ggg gtg cag cac ttc cag cgg gac acg      779
Ala Arg Cys Ile Arg Asn Pro Gly Val Gln His Phe Gln Arg Asp Thr         
65                  70                  75                  80          

ctg tgc ggg ccc tac gcc gag agc ttc ggc gag atc gcc agc ggc ttc      827
Leu Cys Gly Pro Tyr Ala Glu Ser Phe Gly Glu Ile Ala Ser Gly Phe         
                85                  90                  95              

tgg cag gcc aca gct att ttc ctg gct gtg gga atc ttt att ctc tgc      875
Trp Gln Ala Thr Ala Ile Phe Leu Ala Val Gly Ile Phe Ile Leu Cys         
            100                 105                 110                 

atg gtg gcc ttg gtg tcc gtc ttc acc atg tgt gta cag agc atc atg      923
Met Val Ala Leu Val Ser Val Phe Thr Met Cys Val Gln Ser Ile Met         
        115                 120                 125                     

aag aaa agc atc ttc aat gtc tgt ggg ctg ttg caa gga att gca ggt      971
Lys Lys Ser Ile Phe Asn Val Cys Gly Leu Leu Gln Gly Ile Ala Gly         
    130                 135                 140                         

cta ttc ctt atc ctc ggt ttg ata ctc tac cct gct ggc tgg ggt tgc     1019
Leu Phe Leu Ile Leu Gly Leu Ile Leu Tyr Pro Ala Gly Trp Gly Cys         
145                 150                 155                 160         

cag aag gcc ata gac tac tgt gga cat tat gca tct gcc tac aaa cct     1067
Gln Lys Ala Ile Asp Tyr Cys Gly His Tyr Ala Ser Ala Tyr Lys Pro         
                165                 170                 175             

gga gac tgc tcc ttg ggc tgg gcc ttt tat acc gcc att ggg ggc aca     1115
Gly Asp Cys Ser Leu Gly Trp Ala Phe Tyr Thr Ala Ile Gly Gly Thr         
            180                 185                 190                 

gtc ctc act ttc atc tgt gct gtc ttc tct gca caa gca gaa att gca     1163
Val Leu Thr Phe Ile Cys Ala Val Phe Ser Ala Gln Ala Glu Ile Ala         
        195                 200                 205                     

acc tct agt gac aaa gta cag gaa gaa att gaa gag ggg aaa aat ctg     1211
Thr Ser Ser Asp Lys Val Gln Glu Glu Ile Glu Glu Gly Lys Asn Leu         
    210                 215                 220                         

atc tgc ctc ctt tag tttggaagag acaatgccat tttctccctt gagtaatctt     1266
Ile Cys Leu Leu                                                         
225                                                                     

gtgaaacagt ccacagtttc atcatttgag tcaagtggag aactaacctt tacctaccaa   1326

agccacgttc cacggcccga ggcttaaaca ggaccaatga gaggccacat ccagctacgc   1386

aaagttactg gacatgcggt ctgcagtgca cattataagg aatggaacat gaaaatagta   1446

tataatccta gacctggagt tgccaagttc tgtcagactc catctccccc aggttcaatg   1506

aaggataata atctaaatca ttagggcagc agtttctctg gtaacggaag agaccgtccg   1566

ccagatctgc aggctgtttc tgctccaaca ctgcttgctt gtgagcatct ctgcctcaga   1626

atggggtttt gggttggagt tcttgttttc ctctgttctt tcaagttgtc tccaacgaac   1686

agaaaactat aaacttactg gggacaggat gtgtgctaaa gggcacagca agacactgtc   1746

ttttgcttag ctgaccaaag gggtcagcag ggatggcgtg gagtcatgct gtggaactta   1806

ttctaggctg aatcctaggg taaggtggat caactgaact gtcactccag agattttaga   1866

aatttgagta aagaaacaat aaggacctat acaatcatat gagaacaaaa atatgaaatc   1926

ttgctagtga agacgtattt tttcttcttc ccagcagcca ggctagcacc agttctggcc   1986

cagtctcctc ttcttctgga gatcacatgt ttttcttcta aggttaggat tgtgctttga   2046

ctgcgaaagg aaacctcact gtttcctcct tccagggact gaggtctcca agctagctgt   2106

ggcttatgca gatgttcact gggaggacct gccagaatct cggcacttgg ggggagacct   2166

ttactcccag tttggtgacc atgctgtagt cagctctatt tccaatcccg acagtagcag   2226

aatggcattc tacaacaaaa agaagctagt tatgggagtt aagtttttgt agttactggt   2286

gttgatcctg aaagcagact gagataacat taaattgctg caactgaaga actgcagcca   2346

agaccttaat tccaggaaag cacagaggac aaagttaatt caaaaagagg cgctagatca   2406

aggtcacagc actgcctaca cctgtttaca aaaagaatca aataccacta tgaataagga   2466

ttcaggggtt tttaatctac tttccataaa ttaccaatat cactgattca ggaagatagt   2526

atctcagaat gaccagagca gcacagaaac aagctactct gacattatgg gagcttcaaa   2586

attgtatcat gatacagaaa cactccttag cactttaaga aagtgagatg gaactgccag   2646

atttctggaa ggagaaaaag tgtaggtatt tgggttcatt aatctgctca cttgaggact   2706

ttgttttgaa aaagtacctt ctgtggacaa ggtattgtgc taccagctat acaaccctga   2766

cttcagagtt tgcaaccttg ccctgagtga atcatgttaa agctgtctga gtctaaagca   2826

ccgtatcttg gtgcagaaca gataattata cagagatgga atgggacaac cgcagtttta   2886

ctacattctg gtgtttggcc tatatgagaa accatcttct cacagattaa gggctaaggg   2946

caaaaggggt gggaggtgtg gaactagcct taatgagttt cccattcctg aaccaaaatt   3006

caaagtgagt gagatgtaaa tcctgtgatt ttggtgaaga aaaaaacggg tatcttcata   3066

gcagcctagg aaaccttaac catatctcta acaccacaca gaaagaggct ggaggagcca   3126

ctggacaaag cttctgtctc tgtgtgtaca tttataatgt tctaaccaag tctcaaacct   3186

tgatgaaaaa cacaaaattt ttccataaac ttatcagaag actcactttt ctttctttct   3246

tggatagaga aaccattttc tgacactagg tttacaatct cagtgtcctt acaagttaag   3306

tcctaagctc acaggatcct ccgagcatgt ccatcacctg ctctttggct aaggtggcag   3366

tgtacctcta gatcaacctg ggaacagtca caagggagtg tgacttcttg gccataataa   3426

actcactcga tagtgtttat gttattaatc tgaatgcaac agaagacaaa agcacaggca   3486

tgcacacaca cagaacccca aaccactaaa aactacctaa acactgactt agtaaatagt   3546

aaaaaggtaa tgttgggact tttaaacctt gaatccatta gccaggcttg ggatgaaagg   3606

accatctaaa atcatgctag tctaaaccat gctcttccac acagctgttt aaaaaccact   3666

gggtatgagg aatatgctag aaagaaatgt taaaaataga ttgttggctc acacttattt   3726

ttctaataaa taggaccatt attactacca ggaaagtctt atttattttg cctgaaattg   3786

gcttaaagaa agtctcatga cgggatggga tgggctgcgc ttctcaatga actctgaggc   3846

agaaatattt gccttggatt ctgtggattc tttaaacctg tgtgctaata attcaaacaa   3906

tgttgcatta attgtataag ggtttttgta tagttttcaa acatctgtgg tgtaatgatc   3966

tttgttaaac atatattctg taaagtgcca tagtcttttt ttatgtgtag catatttaaa   4026

aatatatatg tatattatac atacacaagt ttgtgtgaaa gatgtgcaat aacaaaggtg   4086

tatgtatgtt ttgttgtttt gttttggaaa ctggacagga gtcaaaacag ggatgtttgt   4146

ttctgttttg gcaaggagag ttccacattt ttgccttcat ggcttattca gtaacccata   4206

attttaatgc tacacaaatc ttatgtgaag aaaagactgg tatgaaatca ttttttcctg   4266

ggtctaaaat aatcgctagt gttatgtcaa agttaagccc gcacgccagg cccagttaat   4326

gctagtcttt catgtgaaat gtgaagctgc catgttgcct tttctcttag taggataact   4386

agtagctggt acataatcac tgaggagcta tttcttaaca tgcttttata gaccatgcta   4446

atgctagacc agtatttaag ggctaatctc acacctcctt agctgtaaga gtctggctta   4506

gaacagacct ctctgtgcaa taacttgtgg ccactggaaa tccctgggcc ggcatttgta   4566

ttggggttgc aatgactccc aagggccaaa agagttaaag gcacgactgg gatttcttct   4626

gagactgtgg tgaaactcct tccaaggctg agggggtcag taggtgctct ggagggactc   4686

ggcaccactt gatattcaac agccacttga gccaaatata aaattgtatt tacagctgat   4746

ggactcaatt tgagccttca aacttgtagt tatcctatta tattgtaaac taatacattg   4806

tctagcattg atttggttcc tgtgcatatg tattttcact atgtgctccc ctccccagat   4866

cttaattaaa ccagattttg caattcaaaa aaaaaaaaaa aaa                     4909


<210>  10
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Cys His Val Ile Val Thr Cys Arg Ser Met Leu Trp Thr Leu Leu 
1               5                   10                  15      


Ser Ile Val Val Ala Phe Ala Glu Leu Ile Ala Phe Met Ser Ala Asp 
            20                  25                  30          


Trp Leu Ile Gly Lys Ala Arg Ser Arg Gly Gly Val Glu Pro Ala Gly 
        35                  40                  45              


Pro Gly Gly Gly Ser Pro Glu Pro Tyr His Pro Thr Leu Gly Ile Tyr 
    50                  55                  60                  


Ala Arg Cys Ile Arg Asn Pro Gly Val Gln His Phe Gln Arg Asp Thr 
65                  70                  75                  80  


Leu Cys Gly Pro Tyr Ala Glu Ser Phe Gly Glu Ile Ala Ser Gly Phe 
                85                  90                  95      


Trp Gln Ala Thr Ala Ile Phe Leu Ala Val Gly Ile Phe Ile Leu Cys 
            100                 105                 110         


Met Val Ala Leu Val Ser Val Phe Thr Met Cys Val Gln Ser Ile Met 
        115                 120                 125             


Lys Lys Ser Ile Phe Asn Val Cys Gly Leu Leu Gln Gly Ile Ala Gly 
    130                 135                 140                 


Leu Phe Leu Ile Leu Gly Leu Ile Leu Tyr Pro Ala Gly Trp Gly Cys 
145                 150                 155                 160 


Gln Lys Ala Ile Asp Tyr Cys Gly His Tyr Ala Ser Ala Tyr Lys Pro 
                165                 170                 175     


Gly Asp Cys Ser Leu Gly Trp Ala Phe Tyr Thr Ala Ile Gly Gly Thr 
            180                 185                 190         


Val Leu Thr Phe Ile Cys Ala Val Phe Ser Ala Gln Ala Glu Ile Ala 
        195                 200                 205             


Thr Ser Ser Asp Lys Val Gln Glu Glu Ile Glu Glu Gly Lys Asn Leu 
    210                 215                 220                 


Ile Cys Leu Leu 
225             


<210>  11
<211>  636
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (85)..(258)
<223>  

<400>  11
gctttccaca ccgcggaagc tttgttcttt tgctctttgc aataaatctt gctgctgctc     60

actctttggg tccacactgc cttt atg agc tgt aac acc gcg aag gtc cac       111
                           Met Ser Cys Asn Thr Ala Lys Val His          
                           1               5                            

agc ttc act cct gag cca gcg aga cca cga acc cca cca gaa gga aga      159
Ser Phe Thr Pro Glu Pro Ala Arg Pro Arg Thr Pro Pro Glu Gly Arg         
10                  15                  20                  25          

atc tgt gaa cac atc cga aca tca gaa gga aca aac tct aga cat gcc      207
Ile Cys Glu His Ile Arg Thr Ser Glu Gly Thr Asn Ser Arg His Ala         
                30                  35                  40              

gcc ttt aag aac tgc aac act cac tgc gag tgt ccg cgg ctt cat tct      255
Ala Phe Lys Asn Cys Asn Thr His Cys Glu Cys Pro Arg Leu His Ser         
            45                  50                  55                  

tga agtcagtgag acgaagaacc caccaattcc agacacattt tggcgaccta           308

gatgggacaa tcgcctatca ccgagtggtg agaccatcgc ctatagctga gcggcgagac    368

aatcacctat cgccaagcaa caagcagatg aatggtgaaa cgatacagca gagaaagaga    428

gaagaggaac atttgaacgc cgagaggagt tcagccgagg gtggtcggag aggtttggcc    488

acccagcagg aagattatct tcccgtgcca tccccgcttc cagctctgca tccatccttc    548

agagaaccac ctccaccact caataaaacc ctgcattcaa ccttcaaaaa aaaaaaaaaa    608

aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                       636


<210>  12
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Cys Asn Thr Ala Lys Val His Ser Phe Thr Pro Glu Pro Ala 
1               5                   10                  15      


Arg Pro Arg Thr Pro Pro Glu Gly Arg Ile Cys Glu His Ile Arg Thr 
            20                  25                  30          


Ser Glu Gly Thr Asn Ser Arg His Ala Ala Phe Lys Asn Cys Asn Thr 
        35                  40                  45              


His Cys Glu Cys Pro Arg Leu His Ser 
    50                  55          


<210>  13
<211>  3228
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (103)..(276)
<223>  

<400>  13
gtggcaacct gcttgggtcc ctttcccacc gtggaagctt tgttcttttg ctctttgcaa     60

taaatcttgc tgctgctcac tctttgggtc cacactgcct tt atg agc tgt aac       114
                                               Met Ser Cys Asn          
                                               1                        

act gcg aag gtc cac agc ttc act cct gag cca gcg aga cca cga acc      162
Thr Ala Lys Val His Ser Phe Thr Pro Glu Pro Ala Arg Pro Arg Thr         
5                   10                  15                  20          

cca cca gaa gga aga atc tgt gaa cac atc cga aca tca gaa gga aca      210
Pro Pro Glu Gly Arg Ile Cys Glu His Ile Arg Thr Ser Glu Gly Thr         
                25                  30                  35              

aac tct aga cat gcc gcc ttt aag aac tgc aac act cac tgc gag tgt      258
Asn Ser Arg His Ala Ala Phe Lys Asn Cys Asn Thr His Cys Glu Cys         
            40                  45                  50                  

ccg cgg ctt cat tct tga agtcagtgag acgaagaacc caccaattcc             306
Pro Arg Leu His Ser                                                     
        55                                                              

agacacattt tggcgaccta gatgggacaa tcgcctatca ctgagtggtg agaccatcgc    366

ctatagctga gcggcgagac aatcacctat cgccaagcag tgagtaccat cggacccctt    426

tcgcttgcta ttctgtcctg tctttgctta gagttcgggg gctaaatact gggcacctgt    486

cggccagtta aaagtgacta gcgcggctgc cggactaaag acaagggtgt caggcttttt    546

gggaaagggc tttctaacaa ctcccgactc ttcggtgttg agaccattgg tttgcctaga    606

accagctttt gcttttcctg tacttctggg ctgagccgag ggtcaacaga gaggaaagcc    666

atgcacctcc ggggtcccga caacaagttg gttgaccctg cgaccatgag cggaactctc    726

aaaggcatgt cgcccaagcg agactcgccc atctatccta tctatcctga gccttgcccc    786

ctggttccta atgcctgcca gacaaacttc ctctctcctc tcttctctga gtttagtccc    846

gcttctaaaa attgctacct gtctctggtg cttttctagt ttctcctata agaatgattt    906

ctagtataga ctccggacac actgccttta agaactgtaa cactcaccac gagggtccgc    966

ggcttcattc ttgaagtcgg tgagaccaag aacccaccaa ttccggacac aatggaatca   1026

tagtgggtca aagttaggtt ttcttaatgt cttctgttac tgcgtgcgat ggcacaactg   1086

gttgggccag attaccgatc tgagtggtgt ccactgatcc atcaagtgca ctgatcttag   1146

gttttacaat agtgatgtta tccccaggag caatttggtg aggtttagac tcttggagag   1206

ggaggctgca ttatccctaa actgttattt ccaatctcgt agctaattgg ttagtcctag   1266

aaaggcagac tggaccccag gtaagaagtg gggtcttttt gggaaagggc tgttaccaat   1326

tttgtttcag agtcaaacct tgagctgaat tccttcccaa agttagctcg gcctacgccc   1386

aggaatgaac aaggacagct tagaggttat gagcaagatg gagccagtta gggcaaatct   1446

tttttcagtg tcttagttat aattttgcaa tggtggtttc acaactttaa atcatgacta   1506

tcatagtttt cataaataat ctaggtaaac aattaaaata aaataattag gtaaatgtaa   1566

tgggataaat acttgtagac aaactggtca taatttagaa tataaagtta aattaaataa   1626

tagatatttt actatttggg cattttccaa taaatatata ttgtaggaaa acattcttgc   1686

taaaaaaaag tgtgtcttta aaaaaaaggt gaacaagttt cgtctaattc aaagcttaaa   1746

ggttatgtgt aaaacaaggt aaaaggaacc aggaaacaaa aaaagatgca tagaaagtta   1806

taaaaataaa agagtttttt taggtaaaga agctgaaaga aaagtaattt taggtaagaa   1866

agaatcctgc atggtaaata tagtcctaaa ataaaataac tggttgttta aaaagaatgt   1926

tgagaacaaa ttagaaagtc tgaccatgtc atgagcggtc agtataagtc acaataagag   1986

gagatatata tatatatata cacacacaca tatatacata tcttttatat catcaggttg   2046

tcatattatt attgttttgg tttgcttaga aatatatata tatatataaa ccttgggcac   2106

ttgtcaggac ttcctgaggc tgtgtcatgg gcgtgtcctc aacgttggca aaataaactt   2166

tctgaattaa ctgagacatg tcttaaattt tgggagttca caagggaaac aagggtaaga   2226

attaaacttc actaatattt ctcaccctcc aaagccactt caaccactgc ctttctcatt   2286

tcggttaata gcaactccaa tcttccagca gtttaggctg caaaacctta gctcctctct   2346

gtcttacact tcacatccaa tctgtcacct attcaaagta tcccccaaat cgagcaattt   2406

ctcaccatct cttactaata cacctcaggt ccaaaccacc agtatacctc cctagagtac   2466

tccaatagtc tcctaagtag ctttcttgct tctatctccc ttcagtttat tcttaacaaa   2526

gcagcctgag tggcccttta aaaatataaa tccaatcagg taattcctct gctcattgcc   2586

ttacaatggg ccatattttg atatggacag gagacaggga aatactggat agaagagggc   2646

agttccctgg caaaggcccc accctcaagc ttggagaccc atggccttaa atgggaacag   2706

ccatttctgt tttcgcaccc caaaagttgc cttttatcct gccatgctcc cctatcctgt   2766

acccatataa accccaaacc tcgggctcca gaagcagatg agcagatgag gagacgcctc   2826

tattccgtgt cgtttagaat gagcaaacag ttgtcttcac catcccagac aagcagatga   2886

atggtgaaac gatacagcag agaaagagag aagaggaaca tttgaacgcc gagaggagtt   2946

cagccgaggg tggtcggaga ggtttggcca cccagcagga agattatctt cccgtgccat   3006

ccccgcttcc agctctgcat ccatccttca gagaaccacc tccaccactc aataaaaccc   3066

tgcattcaac cttcaaaaaa aaaaaaaaaa aaattcttcc aggatgctgg gcaagagctt   3126

gggatacwaa aagtggtcac attggccctc tgcccttgtg aaaaggcaga gtgtccattg   3186

agccgattaa cattcaagcc atccactgac agcagggcta aa                      3228


<210>  14
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Cys Asn Thr Ala Lys Val His Ser Phe Thr Pro Glu Pro Ala 
1               5                   10                  15      


Arg Pro Arg Thr Pro Pro Glu Gly Arg Ile Cys Glu His Ile Arg Thr 
            20                  25                  30          


Ser Glu Gly Thr Asn Ser Arg His Ala Ala Phe Lys Asn Cys Asn Thr 
        35                  40                  45              


His Cys Glu Cys Pro Arg Leu His Ser 
    50                  55          


<210>  15
<211>  2079
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (370)..(663)
<223>  

<400>  15
attttgaggt aagaggacac tctagctttt tgaattgcca gagttcttgc actgattttt     60

tctcttctgg tagggttagt gttccattaa ctgtagtgta tgttgagtat aggcaattgg    120

ttttgtttct ggatgctttc aaagtgccag ggctttctct gtccaggatt tttatgtatg    180

agtaattctt gtgtttggtt tcacaggtta tgtatatgta gcaggataaa ttttgatgtt    240

gtagtttggg atgtgatcca atgcatggtg cttaagagta atggccagtg gctagcctaa    300

tacccagtgg catggctgtt ttatacttcc ttttgtttgc aggtgtgctc tatagtgggg    360

gtgggagag atg cct cta tca cca gat ctg ctc ctg ggc cct ggg gga gtc    411
          Met Pro Leu Ser Pro Asp Leu Leu Leu Gly Pro Gly Gly Val       
          1               5                   10                        

tcc tgc aat cac tgt gtt tct tgt gtt agg tgt tct agg cca cag gtc      459
Ser Cys Asn His Cys Val Ser Cys Val Arg Cys Ser Arg Pro Gln Val         
15                  20                  25                  30          

tct ctc agg cag agg cca ttt cct agg agc cat tct ggg gaa cta gct      507
Ser Leu Arg Gln Arg Pro Phe Pro Arg Ser His Ser Gly Glu Leu Ala         
                35                  40                  45              

gta gtg ttt ggg ttc cct gca cag gct tcc tcc ctc ttc aac tca gct      555
Val Val Phe Gly Phe Pro Ala Gln Ala Ser Ser Leu Phe Asn Ser Ala         
            50                  55                  60                  

tca ttg ctg cct ctc cat cca ctc agc att ttc tct ctc aag atc tgc      603
Ser Leu Leu Pro Leu His Pro Leu Ser Ile Phe Ser Leu Lys Ile Cys         
        65                  70                  75                      

cta aat tac ggt ggt tta ctc cat aat ttg gta tct gtc agt ggg ggt      651
Leu Asn Tyr Gly Gly Leu Leu His Asn Leu Val Ser Val Ser Gly Gly         
    80                  85                  90                          

ggt gct tcc tga ccatgtcaaa ttgaccatct attgtcgcag aatgaaaacc          703
Gly Ala Ser                                                             
95                                                                      

tctttgatag actttgtaac atttttgaat attacattca ggagtaaaat cttacgcagt    763

gtgatcccag ctatctcttc acttttgaga atagccttaa gtaattaaag gataattaaa    823

tatgtaatta aaaattgaaa aatagaacag ctacacttcc agatcccaac ttctttcaga    883

aaattttaaa atctctttaa agaaacgtaa attgagacca aaatagacta atagctttat    943

aaaaataagt gctcaaggag ggtgttacat gtgaaaatta aacttggaat ttgtcttttt   1003

acccgtaaaa ttactgagag taatttcctt gaaatggaaa taactttaca aatttttaat   1063

taacaaaaat gctaaaatat tactccgctt acctttatgt aacctcttcc ttgaaaacaa   1123

caatttactc atctggtgtg tgactctaat aaccttcaat cattctctac atctgacacc   1183

atgactagta acttagatct ttaactaagc aacctttctt tccgcctttg tgatattata   1243

tctagtaatt taataacaat ctatgttgca aattaaactt ccaaattgaa tactaatttt   1303

caaatcccaa ggacccattt ctcctgcctc agcatcccga gtacaggcac tacaggcaca   1363

tgaacaagag aagctgacag attcaaatgt tcacaaacat ttctgttcca ttttgataga   1423

tacataaact atatttctca ttcttatata ctttatatta gggcatgaga ttaaagtcaa   1483

aatagtggaa aattagtaga aataacatat tttatatcca atttagtctc caaaatccca   1543

acatgtactc ttctatatac atttttcagt atgcttgact ggaatggcca attctacagt   1603

agtcttggaa gcaacatact gcagattaaa taccttagta gcctatgttc ttgaatgtgg   1663

acataaagga gcaatgcttt tcctatctta aaaaaaacag tttatatgaa tgaaacttct   1723

gttctgttta agatattata tgttgttgag tgtagttgtc aaagcaacta gcactattcc   1783

aagtaatata gaaatcatca gcttgagttg ggtctgccat aacagcacct aaaacatatc   1843

cactaaatta gtattaaatg gacaagtaaa ccaaactcag agggttgaaa tgaagacttg   1903

taatacccag tgaaaaaaaa ttattgaaac taccatctaa aattaattgg aagcttaata   1963

ttaactcaag gaaagagtgt gggaaatgag gaaaggcaaa aggtaatgtg ttcatgtttg   2023

ttctgttcca taatctaaga aatagataaa cacaggcaaa aaaaaaaaaa aaaaaa       2079


<210>  16
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Pro Leu Ser Pro Asp Leu Leu Leu Gly Pro Gly Gly Val Ser Cys 
1               5                   10                  15      


Asn His Cys Val Ser Cys Val Arg Cys Ser Arg Pro Gln Val Ser Leu 
            20                  25                  30          


Arg Gln Arg Pro Phe Pro Arg Ser His Ser Gly Glu Leu Ala Val Val 
        35                  40                  45              


Phe Gly Phe Pro Ala Gln Ala Ser Ser Leu Phe Asn Ser Ala Ser Leu 
    50                  55                  60                  


Leu Pro Leu His Pro Leu Ser Ile Phe Ser Leu Lys Ile Cys Leu Asn 
65                  70                  75                  80  


Tyr Gly Gly Leu Leu His Asn Leu Val Ser Val Ser Gly Gly Gly Ala 
                85                  90                  95      


Ser 
    


<210>  17
<211>  4292
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (956)..(1330)
<223>  

<400>  17
gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga     60

gagagagaga gagagagaga gagagagaga gagagagaga cagagagaac tagtctcgag    120

tttttttttt tttttttttt ttaactaaaa aggggtcaca gaatttcagc agttctctga    180

tttttatatt ttattcctct tcctatccaa tccctgcctt ttgagtccag gtggtaagta    240

cattttcttt aacgtttttc ctgcttttct tcccaaatgt gtctttttct ttgggctact    300

gtaccctgct tccagtgctg tccccggcat aggtccatct ctgcagaagc catttcagga    360

gtacctggag gctcaacggc agaagcttca ccacaaaagc gaaatgggca caccacaggt    420

aagactttaa tccggtttct tctcccctct gggaagtttc gggctgaaat tacattcaca    480

gctctcactc acatttttag gcaaataagt gaagttggtt tgccagtgtt ccttgacaga    540

agttgagcgt ctgtgtatgc tctactggga aatttgtctt tgtcttagac tagaaagtgt    600

aacttctgta catcttctcc taaaaacaag ggtagagcca atggaaagta atggttctgt    660

tacatagaat gagttgttgc cttgatctta aatgatgtat tggtagatat acttcccaag    720

tggattaaaa agttaaaact tacagcataa caaagtatta gacttactga ggtgacttga    780

atatctcctt ttgattttca ctctattttt cttttcaccc atgggaaaat gataattttt    840

taataaacca aggctcttac catagctgaa ctttaaaact tagactgtct tttctgtaaa    900

cgattctgag gcaaagggaa atgactagaa gaggatgagt aaacaataac ctgaa atg     958
                                                             Met        
                                                             1          

gga aac tcg agg gaa gca cag gtt ttt ttt gtt ttg ttt tgt ttg gtt     1006
Gly Asn Ser Arg Glu Ala Gln Val Phe Phe Val Leu Phe Cys Leu Val         
            5                   10                  15                  

cgt ttt ttg ttc ttt ggg gtt ttt ttg aga cag aat ttc gct ctc gtt     1054
Arg Phe Leu Phe Phe Gly Val Phe Leu Arg Gln Asn Phe Ala Leu Val         
        20                  25                  30                      

gcc caa gtt gga gtg caa tgg cgc gat ctt ggc tca ctg caa cct ccg     1102
Ala Gln Val Gly Val Gln Trp Arg Asp Leu Gly Ser Leu Gln Pro Pro         
    35                  40                  45                          

cct ccc ggg ttc aag cga ttc tcc tgc ctc agc ctc cca agt agc tgt     1150
Pro Pro Gly Phe Lys Arg Phe Ser Cys Leu Ser Leu Pro Ser Ser Cys         
50                  55                  60                  65          

gat tcc agg cac gtg cca cca cac cag cta att ttt tgt att tta ata     1198
Asp Ser Arg His Val Pro Pro His Gln Leu Ile Phe Cys Ile Leu Ile         
                70                  75                  80              

gaa aca ggg ttt cac cgt gtt agc cag gct ggt ctc aaa ctg acc tca     1246
Glu Thr Gly Phe His Arg Val Ser Gln Ala Gly Leu Lys Leu Thr Ser         
            85                  90                  95                  

gat gat ccg ccc gcc ttg gcc tcc caa agt gct ggg att aca gat gtg     1294
Asp Asp Pro Pro Ala Leu Ala Ser Gln Ser Ala Gly Ile Thr Asp Val         
        100                 105                 110                     

agc cac cgc gcc cgg cca gag cac tgt ttt ttt taa tggccttgca          1340
Ser His Arg Ala Arg Pro Glu His Cys Phe Phe                             
    115                 120                                             

ctcttcttat ggacctttgc tgccctcagt tgaccaaaca tgacatcaga aacagataca   1400

tttgtgtgtt ttaaaaacag ctcctaatac tggaacaaaa atatttaact gtcttgacaa   1460

tactcatgag tatctgcatg gcgacttcag agttgagttt aatcaaagag tttattctta   1520

ggtcctagta gaagagctaa cctcacactc atcccattct aaactatgtg attcaacact   1580

gattttacat ccaacaaagt gaaatcttga tagttgggtg taaaaaggag agtaatggag   1640

atttcagagt agttggggtt gcttactttt catttttaat tctttaggtt ttgtaagtta   1700

cacacttcaa gcattataga tgatcctctt tttactactg aactaatgaa gcctttttca   1760

ttgcattgtt ctgcatttat ttctacaggg agaaaactgg ttgtcctgga tgtttgaaaa   1820

gttggtcgtt gtcatggtgt gttacttcat cctatctatc attaactcca tggcacaaag   1880

ttatgccaaa cgaatccagc agcggttgaa ctcagaggag aaaactaaat aagtagagaa   1940

agttttaaac tgcagaaatt ggagtggatg ggttctgcct taaattggga ggactccaag   2000

ccgggaagga aaattccctt ttccaacctg tatcaatttt tacaactttt ttcctgaaag   2060

cagtttagtc catactttgc actgacatac tttttccttc tgtgctaagg taaggtatcc   2120

accctcgatg caatccacct tgtgttttct tagggtggaa tgtgatgttc agcagcaaac   2180

ttgcaacaga ctggccttct gtttgttact ttcaaaaggc ccacatgata caattagaga   2240

attcccaccg cacaaaaaaa gttcctaagt atgttaaata tgtcaagctt tttaggcttg   2300

tcacaaatga ttgctttgtt ttcctaagtc atcaaaatgt atataaatta tctagattgg   2360

ataacagtct tgcatgttta tcatgttaca atttaatatt ccatcctgcc caacccttcc   2420

tctcccatcc tcaaaaaagg gccattttat gatgcattgc acaccctctg gggaaattga   2480

tctttaaatt ttgagacagt ataaggaaaa tctggttggt gtcttacaag tgagctgaca   2540

ccatttttta ttctgtgtat ttagaatgaa gtcttgaaaa aaactttata aagacatctt   2600

taatcattcc aaaattgtgt ccgttttctt gagcgttttg attttttact tttagcttat   2660

accagctgaa tggcagcctt gcctaatcca cctacaacaa gaatttctta agctttcttt   2720

tatttgcatg agagagccac taccaaggca tgttttgtta tgctgaaact gggctgctgc   2780

atactgctaa atggcacctc tgggattggc ctacctgggg atttcttggt ttgtgaaaac   2840

aggagaggag aaatatctca tacaagtgaa aggatactgg agagagaaat tacccatttc   2900

taaaaaaaaa ccacactctg tcgtatctgt gttaatgttt tctagcatgt actctggttt   2960

caacagacac aaatttatat gttaacccag ttttcttgcc gttctgtaag tgttttattc   3020

ttagtgtgat ttttttccat tgggatgttt ttgattgaac ttgttcattt tgttttgctt   3080

gggaggaaaa taaacaattt tacttttttc ctttaggagc attatgagca ttatgtcaga   3140

atagaataga attggggttc gatcttaaca ggccagaaat gcctgggttt ttttggtttg   3200

tttttgtttt tgttttttta tcaaatcctg cctgactgtc tgcttgtttt gcctaccatc   3260

gtgacatctc catggctgta ccaccttgtc gggtagctta tcagactgat gttgactgtt   3320

gaatctcatg gcaacaccag tcgatgggct gtctgacatt ttggtatctt tcatctgacc   3380

atccatatcc aatgttctca tttaaacatt acccagcatc attgtttata atcagaaact   3440

ctggtccttc tgtctggtgg cacttagagt cttttgtgcc ataatgcagc agtatggagg   3500

gaggatttta tggagaaatg gggatagtct tcatgaccac aaataaataa aggaaaacta   3560

agctgcattg tgggttttga aaaggttatt atacttctta acaattcttt ttttcaggga   3620

cttttctagc tgtatgactg ttacttgacc ttctttgaaa agcattccca aaatgctcta   3680

ttttagatag attaacatta accaacataa ttttttttag atcgagtcag cataaatttc   3740

taagtcagcc tctagtcgtg gttcatctct ttcacctgca ttttatttgg tgtttgtctg   3800

aagaaaggaa agaggaaagc aaatacgaat tgtactattt gtaccaaatc tttgggattc   3860

attggcaaat aatttcagtg tggtgtatta ttaaatagaa aaaaaaaatt ttgtttccta   3920

ggttgaaggt ctaattgata cgtttgactt atgatgacca tttatgcact ttcaaatgaa   3980

tttgctttca aaataaatga agagcagctg tccttctttc ctcttttaag tgttcagctg   4040

tggcatgctc agaggttcct gctggattcc agctggagcg gtgtgatacc cttctttttc   4100

agctgttcgt gccttccttt cttgtatcca ccaaagtgga gacaaataca tgatctcaaa   4160

gatacacagt acctacttaa ttccagctga tgggagacca aagaatttgc aagtggatgg   4220

tttggtatca ctgtaaataa aaagagggcc tgggaattct tgcgattcca aaaaaaaaaa   4280

aaaaaaaaaa aa                                                       4292


<210>  18
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Asn Ser Arg Glu Ala Gln Val Phe Phe Val Leu Phe Cys Leu 
1               5                   10                  15      


Val Arg Phe Leu Phe Phe Gly Val Phe Leu Arg Gln Asn Phe Ala Leu 
            20                  25                  30          


Val Ala Gln Val Gly Val Gln Trp Arg Asp Leu Gly Ser Leu Gln Pro 
        35                  40                  45              


Pro Pro Pro Gly Phe Lys Arg Phe Ser Cys Leu Ser Leu Pro Ser Ser 
    50                  55                  60                  


Cys Asp Ser Arg His Val Pro Pro His Gln Leu Ile Phe Cys Ile Leu 
65                  70                  75                  80  


Ile Glu Thr Gly Phe His Arg Val Ser Gln Ala Gly Leu Lys Leu Thr 
                85                  90                  95      


Ser Asp Asp Pro Pro Ala Leu Ala Ser Gln Ser Ala Gly Ile Thr Asp 
            100                 105                 110         


Val Ser His Arg Ala Arg Pro Glu His Cys Phe Phe 
        115                 120                 


<210>  19
<211>  1625
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (135)..(839)
<223>  

<400>  19
ctcaggccgg ggcgcgaccg cggatccgca gttcccgggc cagcctgggg cggccggcca     60

ggaaccaccc gttaaggtgt cttctcttta gggatggtga ggttggaaaa aggctcctgt    120

aaccctcctc cagg atg aac cac ctg cca gaa gac atg gag aac gct ctc      170
                Met Asn His Leu Pro Glu Asp Met Glu Asn Ala Leu         
                1               5                   10                  

acc ggg agc cag agc tcc cat gct tct ctg cgc aat atc cat tcc atc      218
Thr Gly Ser Gln Ser Ser His Ala Ser Leu Arg Asn Ile His Ser Ile         
        15                  20                  25                      

aac ccc aca caa ctc atg gcc agg att gag tcc tat gaa gga agg gaa      266
Asn Pro Thr Gln Leu Met Ala Arg Ile Glu Ser Tyr Glu Gly Arg Glu         
    30                  35                  40                          

aag aaa ggc ata tct gat gtc agg agg act ttc tgt ttg ttt gtc acc      314
Lys Lys Gly Ile Ser Asp Val Arg Arg Thr Phe Cys Leu Phe Val Thr         
45                  50                  55                  60          

ttt gac ctc tta ttc gta aca tta ctg tgg ata ata gag tta aat gtg      362
Phe Asp Leu Leu Phe Val Thr Leu Leu Trp Ile Ile Glu Leu Asn Val         
                65                  70                  75              

aat gga ggc att gag aac aca tta gag aag gag gtg atg cag tat gac      410
Asn Gly Gly Ile Glu Asn Thr Leu Glu Lys Glu Val Met Gln Tyr Asp         
            80                  85                  90                  

tac tat tct tca tat ttt gat ata ttt ctt ctg gca gtt ttt cga ttt      458
Tyr Tyr Ser Ser Tyr Phe Asp Ile Phe Leu Leu Ala Val Phe Arg Phe         
        95                  100                 105                     

aaa gtg tta ata ctt gca tat gct gtg tgc aga ctg cgc cat tgg tgg      506
Lys Val Leu Ile Leu Ala Tyr Ala Val Cys Arg Leu Arg His Trp Trp         
    110                 115                 120                         

gca ata gcg ttg aca acg gca gtg acc agt gcc ttt tta cta gca aaa      554
Ala Ile Ala Leu Thr Thr Ala Val Thr Ser Ala Phe Leu Leu Ala Lys         
125                 130                 135                 140         

gtg atc ctt tcg aag ctt ttc tct caa ggg gct ttt ggc tat gtg ctg      602
Val Ile Leu Ser Lys Leu Phe Ser Gln Gly Ala Phe Gly Tyr Val Leu         
                145                 150                 155             

ccc atc att tca ttc atc ctt gcc tgg att gag acg tgg ttc ctg gat      650
Pro Ile Ile Ser Phe Ile Leu Ala Trp Ile Glu Thr Trp Phe Leu Asp         
            160                 165                 170                 

ttc aaa gtg tta cct caa gaa gca gaa gaa gaa aac aga ctc ctg ata      698
Phe Lys Val Leu Pro Gln Glu Ala Glu Glu Glu Asn Arg Leu Leu Ile         
        175                 180                 185                     

gtt cag gat gct tca gag agg gca gca ctt ata cct ggt ggt ctt tct      746
Val Gln Asp Ala Ser Glu Arg Ala Ala Leu Ile Pro Gly Gly Leu Ser         
    190                 195                 200                         

gat ggt cag ttt tat tcc cct cct gaa tcc gaa gca gga tct gaa gaa      794
Asp Gly Gln Phe Tyr Ser Pro Pro Glu Ser Glu Ala Gly Ser Glu Glu         
205                 210                 215                 220         

gct gaa gaa aaa cag gac agt gag aaa cca ctt tta gaa cta tga          839
Ala Glu Glu Lys Gln Asp Ser Glu Lys Pro Leu Leu Glu Leu                 
                225                 230                                 

gtactacttt tgttaaatgt gaaaaaccgt cacagaaagt catcgaggca aaaagaggca    899

ggcagtggag tctccctgtc gacagtaaag ttgaaatggt gacgtccact gctggcttta    959

ttgaacagct aataaagatt tatttattgt aatacctcac agacgttgca ccatatccat   1019

gcacatttag ttgcctgcct gtggctggta aggtaatgtc atgattcatc ctctcttcag   1079

tgagactgag cctgatgtgt taacaaatag gtgaagaaag tcttgtgctg tattcctaat   1139

caaaagactt aatatattga agtaacactt ttttagtaag caagatacct ttttatttca   1199

attcacagaa tggaattttt ttgtttcatg tctcagattt attttgtatt tcttttttaa   1259

cactctacat ttcccttgtt ttttaactca tgcacatgtg ctctttgtac agttttaaaa   1319

agtgtaataa aatctgacat gtcaatgtgg ctagttttat ttttcttgtt ttgcattatg   1379

tgtatggcct gaagtgttgg acttgcaaaa ggggaagaaa ggaattgcga atacatgtaa   1439

aatgtcacga gacatttgta ttatttttat catgaaatca tgtttttctc tgattgttct   1499

gaaatgttct aaatactctt attttgaatg cacaaaatga cttaaaccat tcatatcatg   1559

tttcctttgc gttcagccaa tttcaattaa aatgaactaa attaaaaaaa aaaaaaaaaa   1619

aaaaaa                                                              1625


<210>  20
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Asn His Leu Pro Glu Asp Met Glu Asn Ala Leu Thr Gly Ser Gln 
1               5                   10                  15      


Ser Ser His Ala Ser Leu Arg Asn Ile His Ser Ile Asn Pro Thr Gln 
            20                  25                  30          


Leu Met Ala Arg Ile Glu Ser Tyr Glu Gly Arg Glu Lys Lys Gly Ile 
        35                  40                  45              


Ser Asp Val Arg Arg Thr Phe Cys Leu Phe Val Thr Phe Asp Leu Leu 
    50                  55                  60                  


Phe Val Thr Leu Leu Trp Ile Ile Glu Leu Asn Val Asn Gly Gly Ile 
65                  70                  75                  80  


Glu Asn Thr Leu Glu Lys Glu Val Met Gln Tyr Asp Tyr Tyr Ser Ser 
                85                  90                  95      


Tyr Phe Asp Ile Phe Leu Leu Ala Val Phe Arg Phe Lys Val Leu Ile 
            100                 105                 110         


Leu Ala Tyr Ala Val Cys Arg Leu Arg His Trp Trp Ala Ile Ala Leu 
        115                 120                 125             


Thr Thr Ala Val Thr Ser Ala Phe Leu Leu Ala Lys Val Ile Leu Ser 
    130                 135                 140                 


Lys Leu Phe Ser Gln Gly Ala Phe Gly Tyr Val Leu Pro Ile Ile Ser 
145                 150                 155                 160 


Phe Ile Leu Ala Trp Ile Glu Thr Trp Phe Leu Asp Phe Lys Val Leu 
                165                 170                 175     


Pro Gln Glu Ala Glu Glu Glu Asn Arg Leu Leu Ile Val Gln Asp Ala 
            180                 185                 190         


Ser Glu Arg Ala Ala Leu Ile Pro Gly Gly Leu Ser Asp Gly Gln Phe 
        195                 200                 205             


Tyr Ser Pro Pro Glu Ser Glu Ala Gly Ser Glu Glu Ala Glu Glu Lys 
    210                 215                 220                 


Gln Asp Ser Glu Lys Pro Leu Leu Glu Leu 
225                 230                 


<210>  21
<211>  8525
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (148)..(8181)
<223>  

<220>
<221>  misc_feature
<222>  (4303)..(4305)
<223>  Xaa=valine or isoleucine


<400>  21
ggtgggctag aggccgacgc cagccagaga gcgaaatgtt cttttggggc cagagtctgg     60

gcatatatga atgcaaatcc gtgtttgttc acaactaagc ccagctgaga cgatcacttt    120

tctgtaggcc atttgtccag gtacaga atg agc aca tgt tgt tgg tgt acg cca    174
                              Met Ser Thr Cys Cys Trp Cys Thr Pro       
                              1               5                         

ggt ggt gct tcc acc att gac ttc cta aag cgc tat gct tcc aac act      222
Gly Gly Ala Ser Thr Ile Asp Phe Leu Lys Arg Tyr Ala Ser Asn Thr         
10                  15                  20                  25          

ccg tcc ggt gaa ttt caa aca gcc gac gaa gac ctc tgc tac tgc ttg      270
Pro Ser Gly Glu Phe Gln Thr Ala Asp Glu Asp Leu Cys Tyr Cys Leu         
                30                  35                  40              

gag tgt gtg gct gag tac cac aaa gca aga gat gaa ttg cca ttc ttg      318
Glu Cys Val Ala Glu Tyr His Lys Ala Arg Asp Glu Leu Pro Phe Leu         
            45                  50                  55                  

cat gag gtt tta tgg gaa tta gaa acc tta cgt ctc ata aat cac ttt      366
His Glu Val Leu Trp Glu Leu Glu Thr Leu Arg Leu Ile Asn His Phe         
        60                  65                  70                      

gaa aaa tcc atg aag gca gaa att gga gat gat gat gag tta tat ata      414
Glu Lys Ser Met Lys Ala Glu Ile Gly Asp Asp Asp Glu Leu Tyr Ile         
    75                  80                  85                          

gta gac aat aat gga gag atg cca ctg ttt gac atc act ggg caa gac      462
Val Asp Asn Asn Gly Glu Met Pro Leu Phe Asp Ile Thr Gly Gln Asp         
90                  95                  100                 105         

ttt gaa aat aag ctt cga gtt cct ctt ctt gaa ata ctg aaa tat cct      510
Phe Glu Asn Lys Leu Arg Val Pro Leu Leu Glu Ile Leu Lys Tyr Pro         
                110                 115                 120             

tac ttg ctt cta cat gaa cgt gtt aac gag tta tgt gtt gaa gca ctt      558
Tyr Leu Leu Leu His Glu Arg Val Asn Glu Leu Cys Val Glu Ala Leu         
            125                 130                 135                 

tgt cgg atg gaa caa gcc aat tgc tcc ttt cag gtg ttt gat aaa cat      606
Cys Arg Met Glu Gln Ala Asn Cys Ser Phe Gln Val Phe Asp Lys His         
        140                 145                 150                     

cca ggg atc tat ttg ttt tta gtc cat ccc aat gaa atg gtt cgg cgt      654
Pro Gly Ile Tyr Leu Phe Leu Val His Pro Asn Glu Met Val Arg Arg         
    155                 160                 165                         

tgg gct atc ttg act gca aga aac ttg ggg aaa gtg gac aga gat gat      702
Trp Ala Ile Leu Thr Ala Arg Asn Leu Gly Lys Val Asp Arg Asp Asp         
170                 175                 180                 185         

tat tat gac tta caa gaa gtt tta ctt tgc ctt ttt aaa gtc att gag      750
Tyr Tyr Asp Leu Gln Glu Val Leu Leu Cys Leu Phe Lys Val Ile Glu         
                190                 195                 200             

ttg ggg ctt tta gag agt cca gac att tat act tct tct gtc cta gag      798
Leu Gly Leu Leu Glu Ser Pro Asp Ile Tyr Thr Ser Ser Val Leu Glu         
            205                 210                 215                 

aag ggt aaa ctg att ctt ctg ccc tca cac atg tat gat act acc aac      846
Lys Gly Lys Leu Ile Leu Leu Pro Ser His Met Tyr Asp Thr Thr Asn         
        220                 225                 230                     

tac aaa agc tat tgg tta ggt att tgc atg ttg ctg acc att ctt gag      894
Tyr Lys Ser Tyr Trp Leu Gly Ile Cys Met Leu Leu Thr Ile Leu Glu         
    235                 240                 245                         

gaa caa gcc atg gat tcc ctg ttg ttg ggc tca gac aaa caa aat gat      942
Glu Gln Ala Met Asp Ser Leu Leu Leu Gly Ser Asp Lys Gln Asn Asp         
250                 255                 260                 265         

ttt atg caa tcg ata ctt cac act atg gag agg gaa gca gat gat gat      990
Phe Met Gln Ser Ile Leu His Thr Met Glu Arg Glu Ala Asp Asp Asp         
                270                 275                 280             

agt gtg gat cct ttc tgg cca gcg tta cac tgt ttt atg gtg att ctg     1038
Ser Val Asp Pro Phe Trp Pro Ala Leu His Cys Phe Met Val Ile Leu         
            285                 290                 295                 

gat cgc ctt gga tct aag gtc tgg ggt caa ctt atg gat cct att gtg     1086
Asp Arg Leu Gly Ser Lys Val Trp Gly Gln Leu Met Asp Pro Ile Val         
        300                 305                 310                     

gca ttt caa acc att atc aac aac gca agc tac aat aga gag atc cga     1134
Ala Phe Gln Thr Ile Ile Asn Asn Ala Ser Tyr Asn Arg Glu Ile Arg         
    315                 320                 325                         

cat ata cgg aac agc tct gta agg acc aag tta gaa ccg gag tcc tat     1182
His Ile Arg Asn Ser Ser Val Arg Thr Lys Leu Glu Pro Glu Ser Tyr         
330                 335                 340                 345         

ttg gat gat atg gtg act tgc agc cag atc gta tac aat tac aat cct     1230
Leu Asp Asp Met Val Thr Cys Ser Gln Ile Val Tyr Asn Tyr Asn Pro         
                350                 355                 360             

gaa aag acc aaa aag gat tct gga tgg aga aca gcc att tgc cca gat     1278
Glu Lys Thr Lys Lys Asp Ser Gly Trp Arg Thr Ala Ile Cys Pro Asp         
            365                 370                 375                 

tat tgt cct aac atg tat gaa gaa atg gaa aca tta gcc agt gta ctt     1326
Tyr Cys Pro Asn Met Tyr Glu Glu Met Glu Thr Leu Ala Ser Val Leu         
        380                 385                 390                     

cag tca gat att ggt caa gac atg cgt gtt cat aac agc aca ttt cta     1374
Gln Ser Asp Ile Gly Gln Asp Met Arg Val His Asn Ser Thr Phe Leu         
    395                 400                 405                         

tgg ttc atc cct ttt gtc cag tcc ctc atg gat ctt aag gat ttg ggt     1422
Trp Phe Ile Pro Phe Val Gln Ser Leu Met Asp Leu Lys Asp Leu Gly         
410                 415                 420                 425         

gtg gct tac ata gca cag gtt gtt aat cat ctg tac tct gaa gtc aaa     1470
Val Ala Tyr Ile Ala Gln Val Val Asn His Leu Tyr Ser Glu Val Lys         
                430                 435                 440             

gaa gtc ctc aac caa aca gat gct gtg tgt gac aaa gtc act gaa ttt     1518
Glu Val Leu Asn Gln Thr Asp Ala Val Cys Asp Lys Val Thr Glu Phe         
            445                 450                 455                 

ttt ctt cta att ttg gta tca gtg att gaa ctg cat aga aat aaa aaa     1566
Phe Leu Leu Ile Leu Val Ser Val Ile Glu Leu His Arg Asn Lys Lys         
        460                 465                 470                     

tgt ttg cat ttg ctg tgg gta agt tcc cag caa tgg gtg gaa gcc gtc     1614
Cys Leu His Leu Leu Trp Val Ser Ser Gln Gln Trp Val Glu Ala Val         
    475                 480                 485                         

gtc aaa tgt gcc aag ctt cct acc act gcg ttt aca cgg agt tct gag     1662
Val Lys Cys Ala Lys Leu Pro Thr Thr Ala Phe Thr Arg Ser Ser Glu         
490                 495                 500                 505         

aaa tca tct gga aat tgc tcc aaa gga aca gca atg ata tct tca ctg     1710
Lys Ser Ser Gly Asn Cys Ser Lys Gly Thr Ala Met Ile Ser Ser Leu         
                510                 515                 520             

tca ttg cat tcc atg cca tct aac tct gta caa ctt gct tat gtg cag     1758
Ser Leu His Ser Met Pro Ser Asn Ser Val Gln Leu Ala Tyr Val Gln         
            525                 530                 535                 

ctg att aga agt ctc ctt aaa gaa ggt tat cag ctt ggg cag cag tct     1806
Leu Ile Arg Ser Leu Leu Lys Glu Gly Tyr Gln Leu Gly Gln Gln Ser         
        540                 545                 550                     

ctt tgc aag cga ttc tgg gat aag ctc aac tta ttc ctt aga gga aat     1854
Leu Cys Lys Arg Phe Trp Asp Lys Leu Asn Leu Phe Leu Arg Gly Asn         
    555                 560                 565                         

tta tct cta ggt tgg cag ttg act agt cag gaa acc cat gag cta caa     1902
Leu Ser Leu Gly Trp Gln Leu Thr Ser Gln Glu Thr His Glu Leu Gln         
570                 575                 580                 585         

agt tgc tta aag caa att att aga aac ata aaa ttc aaa gca cct cca     1950
Ser Cys Leu Lys Gln Ile Ile Arg Asn Ile Lys Phe Lys Ala Pro Pro         
                590                 595                 600             

tgt aac act ttt gtg gat ctg act tct gca tgt aaa atc tct cct gca     1998
Cys Asn Thr Phe Val Asp Leu Thr Ser Ala Cys Lys Ile Ser Pro Ala         
            605                 610                 615                 

tct tat aat aaa gaa gaa agt gaa caa atg ggg aag acg tct aga aaa     2046
Ser Tyr Asn Lys Glu Glu Ser Glu Gln Met Gly Lys Thr Ser Arg Lys         
        620                 625                 630                     

gat atg cat tgt ttg gaa gct tcc agc cca aca ttt tct aaa gaa cca     2094
Asp Met His Cys Leu Glu Ala Ser Ser Pro Thr Phe Ser Lys Glu Pro         
    635                 640                 645                         

atg aaa gtg caa gac agt gta ttg atc aaa gca gat aac act ata gaa     2142
Met Lys Val Gln Asp Ser Val Leu Ile Lys Ala Asp Asn Thr Ile Glu         
650                 655                 660                 665         

ggt gac aat aat gag caa aat tat ata aag gat gtg aaa cta gag gac     2190
Gly Asp Asn Asn Glu Gln Asn Tyr Ile Lys Asp Val Lys Leu Glu Asp         
                670                 675                 680             

cat ctc tta gct ggg tca tgc tta aag cag agt agt aaa aac att ttt     2238
His Leu Leu Ala Gly Ser Cys Leu Lys Gln Ser Ser Lys Asn Ile Phe         
            685                 690                 695                 

act gaa aga gct gaa gat caa att aaa ata agt aca agg aag cag aag     2286
Thr Glu Arg Ala Glu Asp Gln Ile Lys Ile Ser Thr Arg Lys Gln Lys         
        700                 705                 710                     

tct gta aaa gag atc tct tca tat aca cca aag gac tgt act tca aga     2334
Ser Val Lys Glu Ile Ser Ser Tyr Thr Pro Lys Asp Cys Thr Ser Arg         
    715                 720                 725                         

aat ggt cca gaa agg gga tgt gac aga gga ata ata gta tca aca cgt     2382
Asn Gly Pro Glu Arg Gly Cys Asp Arg Gly Ile Ile Val Ser Thr Arg         
730                 735                 740                 745         

ttg ttg act gat tct agc act gat gct ttg gaa aaa gtg tcc aca tcg     2430
Leu Leu Thr Asp Ser Ser Thr Asp Ala Leu Glu Lys Val Ser Thr Ser         
                750                 755                 760             

aat gaa gat ttc tct tta aag gat gat gct ctt gct aaa acc tca aaa     2478
Asn Glu Asp Phe Ser Leu Lys Asp Asp Ala Leu Ala Lys Thr Ser Lys         
            765                 770                 775                 

cga aaa act aag gta cag aaa gat gaa atc tgt gca aag tta tca cat     2526
Arg Lys Thr Lys Val Gln Lys Asp Glu Ile Cys Ala Lys Leu Ser His         
        780                 785                 790                     

gta ata aag aag caa cac agg aag agt act ttg gtc gat aat act atc     2574
Val Ile Lys Lys Gln His Arg Lys Ser Thr Leu Val Asp Asn Thr Ile         
    795                 800                 805                         

aat tta gat gaa aat ttg act gta tct aac att gag agt ttc tat tca     2622
Asn Leu Asp Glu Asn Leu Thr Val Ser Asn Ile Glu Ser Phe Tyr Ser         
810                 815                 820                 825         

agg aaa gat aca gga gtt cag aaa gga gat ggt ttc ata cac aat ctt     2670
Arg Lys Asp Thr Gly Val Gln Lys Gly Asp Gly Phe Ile His Asn Leu         
                830                 835                 840             

tct tta gac cct agt ggt gtt ctg gat gat aag aat gga gaa caa aaa     2718
Ser Leu Asp Pro Ser Gly Val Leu Asp Asp Lys Asn Gly Glu Gln Lys         
            845                 850                 855                 

tct caa aac aat gta ttg cca aaa gag aaa caa tta aag aat gaa gaa     2766
Ser Gln Asn Asn Val Leu Pro Lys Glu Lys Gln Leu Lys Asn Glu Glu         
        860                 865                 870                     

tta gtt att ttc tct ttc cat gaa aac aat tgt aaa ata cag gaa ttt     2814
Leu Val Ile Phe Ser Phe His Glu Asn Asn Cys Lys Ile Gln Glu Phe         
    875                 880                 885                         

cat gtt gat ggt aaa gaa ttg atc cct ttt aca gaa atg acc aat gct     2862
His Val Asp Gly Lys Glu Leu Ile Pro Phe Thr Glu Met Thr Asn Ala         
890                 895                 900                 905         

tca gag aag aaa tca tct ccc ttt aaa gat ctt atg act gta cct gaa     2910
Ser Glu Lys Lys Ser Ser Pro Phe Lys Asp Leu Met Thr Val Pro Glu         
                910                 915                 920             

tca aga gat gag gag atg agt aat agt acc agt gtg att tat tct aac     2958
Ser Arg Asp Glu Glu Met Ser Asn Ser Thr Ser Val Ile Tyr Ser Asn         
            925                 930                 935                 

ttg aca aga gaa cag gcc cct gac atc agt cct aaa tct gac acc tta     3006
Leu Thr Arg Glu Gln Ala Pro Asp Ile Ser Pro Lys Ser Asp Thr Leu         
        940                 945                 950                     

acg gat tct cag ata gac aga gac ctt cac aaa tta tct tta cta gct     3054
Thr Asp Ser Gln Ile Asp Arg Asp Leu His Lys Leu Ser Leu Leu Ala         
    955                 960                 965                         

caa gcc agt gtt att acg ttc cca tcc gat tca cct cag aac tca tcg     3102
Gln Ala Ser Val Ile Thr Phe Pro Ser Asp Ser Pro Gln Asn Ser Ser         
970                 975                 980                 985         

cag ctg caa agg aaa gta aaa gaa gat aaa aga tgt ttc aca gct  aac    3150
Gln Leu Gln Arg Lys Val Lys Glu Asp Lys Arg Cys Phe Thr Ala  Asn        
                990                 995                 1000            

caa aat aat gtt  gga gat acc tcc cgt  gga cag gtt att att  att      3195
Gln Asn Asn Val  Gly Asp Thr Ser Arg  Gly Gln Val Ile Ile  Ile          
            1005                 1010                 1015              

tca gat tct gat  gat gat gat gat gaa  aga atc ctg agt ctt  gag      3240
Ser Asp Ser Asp  Asp Asp Asp Asp Glu  Arg Ile Leu Ser Leu  Glu          
            1020                 1025                 1030              

aaa ctc act aaa  cag gac aaa ata tgc  ctt gag agg gaa cat  cca      3285
Lys Leu Thr Lys  Gln Asp Lys Ile Cys  Leu Glu Arg Glu His  Pro          
            1035                 1040                 1045              

gag cag cac gtt  tca aca gtt aat agt  aag gag gaa aag aat  cca      3330
Glu Gln His Val  Ser Thr Val Asn Ser  Lys Glu Glu Lys Asn  Pro          
            1050                 1055                 1060              

gta aag gaa gaa  aag aca gag act ctt  ttt cag ttt gag gaa  tct      3375
Val Lys Glu Glu  Lys Thr Glu Thr Leu  Phe Gln Phe Glu Glu  Ser          
            1065                 1070                 1075              

gat tct cag tgt  ttt gag ttt gaa agt  tca tct gaa gtg ttt  tca      3420
Asp Ser Gln Cys  Phe Glu Phe Glu Ser  Ser Ser Glu Val Phe  Ser          
            1080                 1085                 1090              

gtt tgg caa gat  cat cca gac gat aat  aat tca gtt caa gat  ggt      3465
Val Trp Gln Asp  His Pro Asp Asp Asn  Asn Ser Val Gln Asp  Gly          
            1095                 1100                 1105              

gag aaa aaa tgt  ttg gct cct ata gcc  aat act aca aat ggt  cag      3510
Glu Lys Lys Cys  Leu Ala Pro Ile Ala  Asn Thr Thr Asn Gly  Gln          
            1110                 1115                 1120              

ggt tgt aca gat  tat gta tct gaa gtt  gtt aaa aaa gga gca  gag      3555
Gly Cys Thr Asp  Tyr Val Ser Glu Val  Val Lys Lys Gly Ala  Glu          
            1125                 1130                 1135              

ggc att gaa gaa  cac aca aga cca cgg  agt att tct gtt gaa  gaa      3600
Gly Ile Glu Glu  His Thr Arg Pro Arg  Ser Ile Ser Val Glu  Glu          
            1140                 1145                 1150              

ttt tgt gaa att  gaa gta aaa aag cct  aag aga aaa cga tct  gaa      3645
Phe Cys Glu Ile  Glu Val Lys Lys Pro  Lys Arg Lys Arg Ser  Glu          
            1155                 1160                 1165              

aaa cca atg gct  gaa gat cct gtg agg  cct tca tct tct gtc  aga      3690
Lys Pro Met Ala  Glu Asp Pro Val Arg  Pro Ser Ser Ser Val  Arg          
            1170                 1175                 1180              

aat gag ggc cag  tct gat act aat aag  aga gat ctt gtg gga  aat      3735
Asn Glu Gly Gln  Ser Asp Thr Asn Lys  Arg Asp Leu Val Gly  Asn          
            1185                 1190                 1195              

gat ttt aaa agt  att gat aga agg act  tca act ccc aat tca  cgt      3780
Asp Phe Lys Ser  Ile Asp Arg Arg Thr  Ser Thr Pro Asn Ser  Arg          
            1200                 1205                 1210              

att cag aga gcc  act acg gtt tca caa  aag aag tct tca aag  ctt      3825
Ile Gln Arg Ala  Thr Thr Val Ser Gln  Lys Lys Ser Ser Lys  Leu          
            1215                 1220                 1225              

tgt act tgt aca  gaa ccc atc agg aaa  gtt cca gtt tct aag  acc      3870
Cys Thr Cys Thr  Glu Pro Ile Arg Lys  Val Pro Val Ser Lys  Thr          
            1230                 1235                 1240              

cct aag aaa act  cat tca gat gcc aaa  aaa gga cag aat aga  agt      3915
Pro Lys Lys Thr  His Ser Asp Ala Lys  Lys Gly Gln Asn Arg  Ser          
            1245                 1250                 1255              

tca aat tac cta  agt tgt aga aca act  cct gct ata gtg ccg  cca      3960
Ser Asn Tyr Leu  Ser Cys Arg Thr Thr  Pro Ala Ile Val Pro  Pro          
            1260                 1265                 1270              

aag aaa ttt cgt  cag tgt cct gag cca  act tca aca gct gag  aaa      4005
Lys Lys Phe Arg  Gln Cys Pro Glu Pro  Thr Ser Thr Ala Glu  Lys          
            1275                 1280                 1285              

ctt ggc ctg aaa  aag ggt cct cgt aag  gca tat gag ttg tcc  cag      4050
Leu Gly Leu Lys  Lys Gly Pro Arg Lys  Ala Tyr Glu Leu Ser  Gln          
            1290                 1295                 1300              

cgg tct ttg gat  tat gta gct caa tta  cgt gat cat ggc aaa  act      4095
Arg Ser Leu Asp  Tyr Val Ala Gln Leu  Arg Asp His Gly Lys  Thr          
            1305                 1310                 1315              

gtt gga gta gtt  gat acc cga aaa aag  act aaa tta att tct  cct      4140
Val Gly Val Val  Asp Thr Arg Lys Lys  Thr Lys Leu Ile Ser  Pro          
            1320                 1325                 1330              

cag aac ctg tct  gtc aga aat aat aag  aaa ctt ctg act agt  caa      4185
Gln Asn Leu Ser  Val Arg Asn Asn Lys  Lys Leu Leu Thr Ser  Gln          
            1335                 1340                 1345              

gaa ctt cag atg  caa agg cag atc aga  ccc aaa tca caa aaa  aat      4230
Glu Leu Gln Met  Gln Arg Gln Ile Arg  Pro Lys Ser Gln Lys  Asn          
            1350                 1355                 1360              

aga cga aga ctt  tct gat tgt gaa agt  aca gat gtt aaa aga  gca      4275
Arg Arg Arg Leu  Ser Asp Cys Glu Ser  Thr Asp Val Lys Arg  Ala          
            1365                 1370                 1375              

ggg tca cat aca  gca cag aat tct gac  rta ttt gta cca gaa  tct      4320
Gly Ser His Thr  Ala Gln Asn Ser Asp  Xaa Phe Val Pro Glu  Ser          
            1380                 1385                 1390              

gat agg tca gat  tat aat tgt aca gga  gga act gag gta ctt  gcc      4365
Asp Arg Ser Asp  Tyr Asn Cys Thr Gly  Gly Thr Glu Val Leu  Ala          
            1395                 1400                 1405              

aac agt aac aga  aaa cag tta ata aaa  tgc atg cct tct gaa  cca      4410
Asn Ser Asn Arg  Lys Gln Leu Ile Lys  Cys Met Pro Ser Glu  Pro          
            1410                 1415                 1420              

gaa acc ata aaa  gca aaa cat ggg tct  cca gca act gat gat  gct      4455
Glu Thr Ile Lys  Ala Lys His Gly Ser  Pro Ala Thr Asp Asp  Ala          
            1425                 1430                 1435              

tgc cct ttg aac  cag tgt gat tct gta  gtg tta aat gga aca  gta      4500
Cys Pro Leu Asn  Gln Cys Asp Ser Val  Val Leu Asn Gly Thr  Val          
            1440                 1445                 1450              

cca aca aat gaa  gta att gtc tcc act  tca gaa gac cct ctg  ggt      4545
Pro Thr Asn Glu  Val Ile Val Ser Thr  Ser Glu Asp Pro Leu  Gly          
            1455                 1460                 1465              

gga ggt gat cca  aca gca cgt cat ata  gag atg gca gct ttg  aaa      4590
Gly Gly Asp Pro  Thr Ala Arg His Ile  Glu Met Ala Ala Leu  Lys          
            1470                 1475                 1480              

gaa gga gag cct  gac tcc agc agt gat  gca gag gaa gat aac  tta      4635
Glu Gly Glu Pro  Asp Ser Ser Ser Asp  Ala Glu Glu Asp Asn  Leu          
            1485                 1490                 1495              

ttt tta acc caa  aat gat cct gaa gat  atg gat tta tgt tca  caa      4680
Phe Leu Thr Gln  Asn Asp Pro Glu Asp  Met Asp Leu Cys Ser  Gln          
            1500                 1505                 1510              

atg gag aat gac  aat tat aaa ctc att  gaa cta att cat gga  aaa      4725
Met Glu Asn Asp  Asn Tyr Lys Leu Ile  Glu Leu Ile His Gly  Lys          
            1515                 1520                 1525              

gat aca gtt gag  gtt gaa gaa gat tct  gta agt cgg cct cag  ttg      4770
Asp Thr Val Glu  Val Glu Glu Asp Ser  Val Ser Arg Pro Gln  Leu          
            1530                 1535                 1540              

gaa tct ttg agt  ggc aca aag tgt aag  tac aaa gat tgt ctt  gaa      4815
Glu Ser Leu Ser  Gly Thr Lys Cys Lys  Tyr Lys Asp Cys Leu  Glu          
            1545                 1550                 1555              

acc aca aaa aac  cag ggt gaa tac tgc  cca aaa cac tct gaa  gtg      4860
Thr Thr Lys Asn  Gln Gly Glu Tyr Cys  Pro Lys His Ser Glu  Val          
            1560                 1565                 1570              

aaa gca gca gat  gaa gat gta ttt cgt  aaa cct ggc ttg cct  cct      4905
Lys Ala Ala Asp  Glu Asp Val Phe Arg  Lys Pro Gly Leu Pro  Pro          
            1575                 1580                 1585              

cct gca tct aaa  cct ttg aga cct acc  act aag att ttt agc  tca      4950
Pro Ala Ser Lys  Pro Leu Arg Pro Thr  Thr Lys Ile Phe Ser  Ser          
            1590                 1595                 1600              

aag agt act tca  cga att gct ggt ctt  tct aaa tct ttg gaa  act      4995
Lys Ser Thr Ser  Arg Ile Ala Gly Leu  Ser Lys Ser Leu Glu  Thr          
            1605                 1610                 1615              

tct tca gca ctt  tca ccg tct cta aaa  aat aag tca aag ggg  ata      5040
Ser Ser Ala Leu  Ser Pro Ser Leu Lys  Asn Lys Ser Lys Gly  Ile          
            1620                 1625                 1630              

cag tcg att ttg  aaa gta cca cag cca  gtt ccc ctc ata gct  cag      5085
Gln Ser Ile Leu  Lys Val Pro Gln Pro  Val Pro Leu Ile Ala  Gln          
            1635                 1640                 1645              

aag cca gtt ggt  gaa atg aag aat tcg  tgc aat gtt ctt cat  cct      5130
Lys Pro Val Gly  Glu Met Lys Asn Ser  Cys Asn Val Leu His  Pro          
            1650                 1655                 1660              

cag tct ccg aat  aat tcc aac agg caa  ggt tgc aaa gtt cca  ttt      5175
Gln Ser Pro Asn  Asn Ser Asn Arg Gln  Gly Cys Lys Val Pro  Phe          
            1665                 1670                 1675              

ggt gaa agc aaa  tat ttt cca tct tcc  tct cca gta aac att  ctt      5220
Gly Glu Ser Lys  Tyr Phe Pro Ser Ser  Ser Pro Val Asn Ile  Leu          
            1680                 1685                 1690              

ttg tca tca cag  tct gtc tct gac acc  ttc gtt aaa gag gtc  tta      5265
Leu Ser Ser Gln  Ser Val Ser Asp Thr  Phe Val Lys Glu Val  Leu          
            1695                 1700                 1705              

aaa tgg aaa tat  gaa atg ttt ttg aac  ttt ggt cag tgt ggg  ccc      5310
Lys Trp Lys Tyr  Glu Met Phe Leu Asn  Phe Gly Gln Cys Gly  Pro          
            1710                 1715                 1720              

cct gca agt ctt  tgt cag tcc atc tca  aga cct gtg cct gtc  aga      5355
Pro Ala Ser Leu  Cys Gln Ser Ile Ser  Arg Pro Val Pro Val  Arg          
            1725                 1730                 1735              

ttt cac aat tat  gga gat tat ttt aat  gtt ttt ttc cct ttg  atg      5400
Phe His Asn Tyr  Gly Asp Tyr Phe Asn  Val Phe Phe Pro Leu  Met          
            1740                 1745                 1750              

gta ttg aat act  ttt gaa aca gtg gca  caa gaa tgg ctc aac  tct      5445
Val Leu Asn Thr  Phe Glu Thr Val Ala  Gln Glu Trp Leu Asn  Ser          
            1755                 1760                 1765              

cca aat aga gag  aat ttc tat cag ttg  caa gta cga aaa ttt  cct      5490
Pro Asn Arg Glu  Asn Phe Tyr Gln Leu  Gln Val Arg Lys Phe  Pro          
            1770                 1775                 1780              

gcc gat tat ata  aaa tac tgg gag ttt  gca gtt tat ctg gaa  gaa      5535
Ala Asp Tyr Ile  Lys Tyr Trp Glu Phe  Ala Val Tyr Leu Glu  Glu          
            1785                 1790                 1795              

tgt gaa ctg gct  aaa cag ctt tat cca  aag gaa aac gat ttg  gtg      5580
Cys Glu Leu Ala  Lys Gln Leu Tyr Pro  Lys Glu Asn Asp Leu  Val          
            1800                 1805                 1810              

ttt tta gct cct  gag aga ata aat gaa  gag aag aaa gat aca  gag      5625
Phe Leu Ala Pro  Glu Arg Ile Asn Glu  Glu Lys Lys Asp Thr  Glu          
            1815                 1820                 1825              

aga aat gac ata  caa gat ctc cac gaa  tat cat tct ggt tat  gtt      5670
Arg Asn Asp Ile  Gln Asp Leu His Glu  Tyr His Ser Gly Tyr  Val          
            1830                 1835                 1840              

cat aaa ttt cgc  cgc acg tca gtc atg  cgt aat ggg aaa act  gag      5715
His Lys Phe Arg  Arg Thr Ser Val Met  Arg Asn Gly Lys Thr  Glu          
            1845                 1850                 1855              

tgt tac ctt tcc  atc cag act caa gag  aac ttt ccg gcc aat  tta      5760
Cys Tyr Leu Ser  Ile Gln Thr Gln Glu  Asn Phe Pro Ala Asn  Leu          
            1860                 1865                 1870              

aac gaa ctt gtg  aat tgt att gta atc  agt tct ctg gta act  aca      5805
Asn Glu Leu Val  Asn Cys Ile Val Ile  Ser Ser Leu Val Thr  Thr          
            1875                 1880                 1885              

caa agg aag ttg  aaa gcc atg tct ctg  ttg ggt agt cgg aac  caa      5850
Gln Arg Lys Leu  Lys Ala Met Ser Leu  Leu Gly Ser Arg Asn  Gln          
            1890                 1895                 1900              

ctg gct aga gct  gtt ctg aat cca aac  cct atg gac ttc tgt  aca      5895
Leu Ala Arg Ala  Val Leu Asn Pro Asn  Pro Met Asp Phe Cys  Thr          
            1905                 1910                 1915              

aaa gat tta ctg  act aca aca tct gag  aga att att gcg tac  tta      5940
Lys Asp Leu Leu  Thr Thr Thr Ser Glu  Arg Ile Ile Ala Tyr  Leu          
            1920                 1925                 1930              

aga gat ttc aat  gaa gat caa aag aaa  gca ata gaa act gca  tat      5985
Arg Asp Phe Asn  Glu Asp Gln Lys Lys  Ala Ile Glu Thr Ala  Tyr          
            1935                 1940                 1945              

gct atg gtg aaa  cac tca cca tca gtt  gcc aaa atc tgc ttg  att      6030
Ala Met Val Lys  His Ser Pro Ser Val  Ala Lys Ile Cys Leu  Ile          
            1950                 1955                 1960              

cat gga cca cct  gga aca gga aaa tca  aaa act att gtt ggc  ctc      6075
His Gly Pro Pro  Gly Thr Gly Lys Ser  Lys Thr Ile Val Gly  Leu          
            1965                 1970                 1975              

ctc tat cgt cta  ctg aca gag aac cag  agg aag ggg cat tca  gac      6120
Leu Tyr Arg Leu  Leu Thr Glu Asn Gln  Arg Lys Gly His Ser  Asp          
            1980                 1985                 1990              

gaa aac tcc aat  gcc aaa atc aaa caa  aac cgt gtc ctc gtg  tgt      6165
Glu Asn Ser Asn  Ala Lys Ile Lys Gln  Asn Arg Val Leu Val  Cys          
            1995                 2000                 2005              

gca cct tcc aat  gca gct gtt gat gaa  ctc atg aaa aaa att  atc      6210
Ala Pro Ser Asn  Ala Ala Val Asp Glu  Leu Met Lys Lys Ile  Ile          
            2010                 2015                 2020              

ctt gaa ttc aaa  gaa aaa tgt aaa gac  aag aag aat cct tta  gga      6255
Leu Glu Phe Lys  Glu Lys Cys Lys Asp  Lys Lys Asn Pro Leu  Gly          
            2025                 2030                 2035              

aac tgt gga gat  ata aat tta gta cga  ctg ggt cca gaa aag  tct      6300
Asn Cys Gly Asp  Ile Asn Leu Val Arg  Leu Gly Pro Glu Lys  Ser          
            2040                 2045                 2050              

att aat agt gag  gtt cta aag ttc agt  ttg gac agc caa gta  aac      6345
Ile Asn Ser Glu  Val Leu Lys Phe Ser  Leu Asp Ser Gln Val  Asn          
            2055                 2060                 2065              

cac aga atg aaa  aaa gag tta cct tct  cat gtt cag gcg atg  cat      6390
His Arg Met Lys  Lys Glu Leu Pro Ser  His Val Gln Ala Met  His          
            2070                 2075                 2080              

aaa aga aag gaa  ttt cta gat tat cag  ctg gat gag ctt tcc  cgg      6435
Lys Arg Lys Glu  Phe Leu Asp Tyr Gln  Leu Asp Glu Leu Ser  Arg          
            2085                 2090                 2095              

cag cga gct cta  tgc cga ggt gga cgg  gaa ata cag agg caa  gaa      6480
Gln Arg Ala Leu  Cys Arg Gly Gly Arg  Glu Ile Gln Arg Gln  Glu          
            2100                 2105                 2110              

tta gat gaa aac  att tcc aaa gtt tct  aag gaa agg cag gaa  ctt      6525
Leu Asp Glu Asn  Ile Ser Lys Val Ser  Lys Glu Arg Gln Glu  Leu          
            2115                 2120                 2125              

gct tct aaa att  aaa gag gtt caa gga  cgc cca cag aaa aca  cag      6570
Ala Ser Lys Ile  Lys Glu Val Gln Gly  Arg Pro Gln Lys Thr  Gln          
            2130                 2135                 2140              

agt atc atc atc  tta gag tcc cat atc  atc tgc tgc acg ttg  agc      6615
Ser Ile Ile Ile  Leu Glu Ser His Ile  Ile Cys Cys Thr Leu  Ser          
            2145                 2150                 2155              

aca agt ggt ggt  tta cta ctt gag tct  gct ttc cgt ggg caa  ggg      6660
Thr Ser Gly Gly  Leu Leu Leu Glu Ser  Ala Phe Arg Gly Gln  Gly          
            2160                 2165                 2170              

ggt gtc ccc ttc  agc tgt gtc att gtt  gat gag gct gga cag  tct      6705
Gly Val Pro Phe  Ser Cys Val Ile Val  Asp Glu Ala Gly Gln  Ser          
            2175                 2180                 2185              

tgt gaa att gag  act ctt act cca ctc  atc cat cgc tgc aat  aag      6750
Cys Glu Ile Glu  Thr Leu Thr Pro Leu  Ile His Arg Cys Asn  Lys          
            2190                 2195                 2200              

ctc atc cta gta  gga gat cct aag cag  ctc cct ccg aca gtc  atc      6795
Leu Ile Leu Val  Gly Asp Pro Lys Gln  Leu Pro Pro Thr Val  Ile          
            2205                 2210                 2215              

tct atg aaa gca  cag gag tat ggc tac  gac cag tca atg atg  gct      6840
Ser Met Lys Ala  Gln Glu Tyr Gly Tyr  Asp Gln Ser Met Met  Ala          
            2220                 2225                 2230              

cgc ttc tgc aga  ctg ctg gaa gag aat  gta gaa cac aac atg  atc      6885
Arg Phe Cys Arg  Leu Leu Glu Glu Asn  Val Glu His Asn Met  Ile          
            2235                 2240                 2245              

agc agg ctg ccc  att cta cag ctc act  gtt cag tac agg atg  cat      6930
Ser Arg Leu Pro  Ile Leu Gln Leu Thr  Val Gln Tyr Arg Met  His          
            2250                 2255                 2260              

cca gac ata tgc  ctc ttc cct tct aat  tat gtt tat aac aga  aac      6975
Pro Asp Ile Cys  Leu Phe Pro Ser Asn  Tyr Val Tyr Asn Arg  Asn          
            2265                 2270                 2275              

tta aaa aca aat  aga cag aca gaa gcc  att cga tgt tca tca  gat      7020
Leu Lys Thr Asn  Arg Gln Thr Glu Ala  Ile Arg Cys Ser Ser  Asp          
            2280                 2285                 2290              

tgg cca ttt cag  cca tac ctt gtg ttt  gat gtt gga gat ggt  tca      7065
Trp Pro Phe Gln  Pro Tyr Leu Val Phe  Asp Val Gly Asp Gly  Ser          
            2295                 2300                 2305              

gaa aga cgg gat  aat gac tca tat ata  aat gtt caa gaa ata  aaa      7110
Glu Arg Arg Asp  Asn Asp Ser Tyr Ile  Asn Val Gln Glu Ile  Lys          
            2310                 2315                 2320              

ctg gtg atg gaa  ata att aag ctt att  aaa gac aaa aga aag  gat      7155
Leu Val Met Glu  Ile Ile Lys Leu Ile  Lys Asp Lys Arg Lys  Asp          
            2325                 2330                 2335              

gtt agt ttt cga  aac att ggc ata ata  act cat tac aag gcc  cag      7200
Val Ser Phe Arg  Asn Ile Gly Ile Ile  Thr His Tyr Lys Ala  Gln          
            2340                 2345                 2350              

aag acg atg att  cag aag gat ttg gac  aaa gag ttc gat aga  aaa      7245
Lys Thr Met Ile  Gln Lys Asp Leu Asp  Lys Glu Phe Asp Arg  Lys          
            2355                 2360                 2365              

gga cca gca gaa  gta gac act gtg gat  gca ttc cag ggt cgg  cag      7290
Gly Pro Ala Glu  Val Asp Thr Val Asp  Ala Phe Gln Gly Arg  Gln          
            2370                 2375                 2380              

aag gat tgt gtt  att gtt acg tgt gtc  aga gca aat agc atc  caa      7335
Lys Asp Cys Val  Ile Val Thr Cys Val  Arg Ala Asn Ser Ile  Gln          
            2385                 2390                 2395              

ggt tca att gga  ttc ctg gca agt ttg  cag aga ttg aat gtc  acc      7380
Gly Ser Ile Gly  Phe Leu Ala Ser Leu  Gln Arg Leu Asn Val  Thr          
            2400                 2405                 2410              

atc aca cga gcc  aag tac agc ctc ttc  atc ctc gga cat ttg  agg      7425
Ile Thr Arg Ala  Lys Tyr Ser Leu Phe  Ile Leu Gly His Leu  Arg          
            2415                 2420                 2425              

acc ctg atg gaa  aac cag cat tgg aat  cag ctg att cag gat  gct      7470
Thr Leu Met Glu  Asn Gln His Trp Asn  Gln Leu Ile Gln Asp  Ala          
            2430                 2435                 2440              

cag aag cgt ggt  gcc att att aag acc  tgt gac aaa aac tat  aga      7515
Gln Lys Arg Gly  Ala Ile Ile Lys Thr  Cys Asp Lys Asn Tyr  Arg          
            2445                 2450                 2455              

cat gat gca gtg  aag att ctg aaa ctc  aag cct gtg ctg cag  aga      7560
His Asp Ala Val  Lys Ile Leu Lys Leu  Lys Pro Val Leu Gln  Arg          
            2460                 2465                 2470              

agt ctc act cac  cct cct acc ata gcc  cca gag ggg tcc aga  ccc      7605
Ser Leu Thr His  Pro Pro Thr Ile Ala  Pro Glu Gly Ser Arg  Pro          
            2475                 2480                 2485              

cag ggt ggt ttg  ccc agc agc aag cta  gac agt gga ttt gcc  aag      7650
Gln Gly Gly Leu  Pro Ser Ser Lys Leu  Asp Ser Gly Phe Ala  Lys          
            2490                 2495                 2500              

aca tct gtt gct  gct tct cta tac cac  aca ccc tct gac tcc  aag      7695
Thr Ser Val Ala  Ala Ser Leu Tyr His  Thr Pro Ser Asp Ser  Lys          
            2505                 2510                 2515              

gaa att act ctt  act gtt act tca aag  gac cct gaa aga cct  cct      7740
Glu Ile Thr Leu  Thr Val Thr Ser Lys  Asp Pro Glu Arg Pro  Pro          
            2520                 2525                 2530              

gtt cat gac caa  ctt cag gac cca cga  ctg ctg aag agg atg  ggc      7785
Val His Asp Gln  Leu Gln Asp Pro Arg  Leu Leu Lys Arg Met  Gly          
            2535                 2540                 2545              

att gag gtc aaa  gga gga ata ttc ctt  tgg gat cca caa ccc  tcg      7830
Ile Glu Val Lys  Gly Gly Ile Phe Leu  Trp Asp Pro Gln Pro  Ser          
            2550                 2555                 2560              

agc ccc cag cat  cct gga gca aca cct  cct acg ggc gag ccg  ggc      7875
Ser Pro Gln His  Pro Gly Ala Thr Pro  Pro Thr Gly Glu Pro  Gly          
            2565                 2570                 2575              

ttc cct gtc gtt  cac cag gac ctg agc  cat ata cag cag ccc  gct      7920
Phe Pro Val Val  His Gln Asp Leu Ser  His Ile Gln Gln Pro  Ala          
            2580                 2585                 2590              

gct gta gtg gct  gct ctg agc agc cac  aaa cct ccc gtg cgg  ggc      7965
Ala Val Val Ala  Ala Leu Ser Ser His  Lys Pro Pro Val Arg  Gly          
            2595                 2600                 2605              

gaa cct cca gct  gcc agt ccc gag gct  tcc acg tgt cag agc  aaa      8010
Glu Pro Pro Ala  Ala Ser Pro Glu Ala  Ser Thr Cys Gln Ser  Lys          
            2610                 2615                 2620              

tgt gat gac ccg  gaa gag gag ctc tgt  cac agg aga gag gcc  agg      8055
Cys Asp Asp Pro  Glu Glu Glu Leu Cys  His Arg Arg Glu Ala  Arg          
            2625                 2630                 2635              

gct ttc agt gaa  ggg gag cag gag aag  tgt ggt tcc gag acc  cat      8100
Ala Phe Ser Glu  Gly Glu Gln Glu Lys  Cys Gly Ser Glu Thr  His          
            2640                 2645                 2650              

cac acc agg agg  aac tct agg tgg gac  aag agg aca ctg gag  cag      8145
His Thr Arg Arg  Asn Ser Arg Trp Asp  Lys Arg Thr Leu Glu  Gln          
            2655                 2660                 2665              

gag gac agc agt  tcc aag aaa aga aag  ctt tta tag gaaagcccag        8191
Glu Asp Ser Ser  Ser Lys Lys Arg Lys  Leu Leu                           
            2670                 2675                                   

tgacatgggc cagcagccac agcatattgt aaactgaaga tgaccagctc gtgggaccat   8251

ctagataagc ttgttttttg taaggagttt gtgtgctgtt ggaaaacatg gaaaatgcat   8311

ccttaacacc tgagcctctg gtcatcttca gtattttctg tcatttgcaa aagctttcag   8371

agggcattgt gtatccgtaa taatgtcctt gaagtcagag actggaaatg ttgatctctt   8431

agtcttctat agacaaggag gtcagactgg agtgaatgtt gtaaaagttg aaatgtatat   8491

ttgtatagca aataacaaaa tccttttaaa attt                               8525


<210>  22
<211>  2677
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1386)..(1386)
<223>  The 'Xaa' at location 1386 stands for Val, or Ile. 

<400>  22

Met Ser Thr Cys Cys Trp Cys Thr Pro Gly Gly Ala Ser Thr Ile Asp 
1               5                   10                  15      


Phe Leu Lys Arg Tyr Ala Ser Asn Thr Pro Ser Gly Glu Phe Gln Thr 
            20                  25                  30          


Ala Asp Glu Asp Leu Cys Tyr Cys Leu Glu Cys Val Ala Glu Tyr His 
        35                  40                  45              


Lys Ala Arg Asp Glu Leu Pro Phe Leu His Glu Val Leu Trp Glu Leu 
    50                  55                  60                  


Glu Thr Leu Arg Leu Ile Asn His Phe Glu Lys Ser Met Lys Ala Glu 
65                  70                  75                  80  


Ile Gly Asp Asp Asp Glu Leu Tyr Ile Val Asp Asn Asn Gly Glu Met 
                85                  90                  95      


Pro Leu Phe Asp Ile Thr Gly Gln Asp Phe Glu Asn Lys Leu Arg Val 
            100                 105                 110         


Pro Leu Leu Glu Ile Leu Lys Tyr Pro Tyr Leu Leu Leu His Glu Arg 
        115                 120                 125             


Val Asn Glu Leu Cys Val Glu Ala Leu Cys Arg Met Glu Gln Ala Asn 
    130                 135                 140                 


Cys Ser Phe Gln Val Phe Asp Lys His Pro Gly Ile Tyr Leu Phe Leu 
145                 150                 155                 160 


Val His Pro Asn Glu Met Val Arg Arg Trp Ala Ile Leu Thr Ala Arg 
                165                 170                 175     


Asn Leu Gly Lys Val Asp Arg Asp Asp Tyr Tyr Asp Leu Gln Glu Val 
            180                 185                 190         


Leu Leu Cys Leu Phe Lys Val Ile Glu Leu Gly Leu Leu Glu Ser Pro 
        195                 200                 205             


Asp Ile Tyr Thr Ser Ser Val Leu Glu Lys Gly Lys Leu Ile Leu Leu 
    210                 215                 220                 


Pro Ser His Met Tyr Asp Thr Thr Asn Tyr Lys Ser Tyr Trp Leu Gly 
225                 230                 235                 240 


Ile Cys Met Leu Leu Thr Ile Leu Glu Glu Gln Ala Met Asp Ser Leu 
                245                 250                 255     


Leu Leu Gly Ser Asp Lys Gln Asn Asp Phe Met Gln Ser Ile Leu His 
            260                 265                 270         


Thr Met Glu Arg Glu Ala Asp Asp Asp Ser Val Asp Pro Phe Trp Pro 
        275                 280                 285             


Ala Leu His Cys Phe Met Val Ile Leu Asp Arg Leu Gly Ser Lys Val 
    290                 295                 300                 


Trp Gly Gln Leu Met Asp Pro Ile Val Ala Phe Gln Thr Ile Ile Asn 
305                 310                 315                 320 


Asn Ala Ser Tyr Asn Arg Glu Ile Arg His Ile Arg Asn Ser Ser Val 
                325                 330                 335     


Arg Thr Lys Leu Glu Pro Glu Ser Tyr Leu Asp Asp Met Val Thr Cys 
            340                 345                 350         


Ser Gln Ile Val Tyr Asn Tyr Asn Pro Glu Lys Thr Lys Lys Asp Ser 
        355                 360                 365             


Gly Trp Arg Thr Ala Ile Cys Pro Asp Tyr Cys Pro Asn Met Tyr Glu 
    370                 375                 380                 


Glu Met Glu Thr Leu Ala Ser Val Leu Gln Ser Asp Ile Gly Gln Asp 
385                 390                 395                 400 


Met Arg Val His Asn Ser Thr Phe Leu Trp Phe Ile Pro Phe Val Gln 
                405                 410                 415     


Ser Leu Met Asp Leu Lys Asp Leu Gly Val Ala Tyr Ile Ala Gln Val 
            420                 425                 430         


Val Asn His Leu Tyr Ser Glu Val Lys Glu Val Leu Asn Gln Thr Asp 
        435                 440                 445             


Ala Val Cys Asp Lys Val Thr Glu Phe Phe Leu Leu Ile Leu Val Ser 
    450                 455                 460                 


Val Ile Glu Leu His Arg Asn Lys Lys Cys Leu His Leu Leu Trp Val 
465                 470                 475                 480 


Ser Ser Gln Gln Trp Val Glu Ala Val Val Lys Cys Ala Lys Leu Pro 
                485                 490                 495     


Thr Thr Ala Phe Thr Arg Ser Ser Glu Lys Ser Ser Gly Asn Cys Ser 
            500                 505                 510         


Lys Gly Thr Ala Met Ile Ser Ser Leu Ser Leu His Ser Met Pro Ser 
        515                 520                 525             


Asn Ser Val Gln Leu Ala Tyr Val Gln Leu Ile Arg Ser Leu Leu Lys 
    530                 535                 540                 


Glu Gly Tyr Gln Leu Gly Gln Gln Ser Leu Cys Lys Arg Phe Trp Asp 
545                 550                 555                 560 


Lys Leu Asn Leu Phe Leu Arg Gly Asn Leu Ser Leu Gly Trp Gln Leu 
                565                 570                 575     


Thr Ser Gln Glu Thr His Glu Leu Gln Ser Cys Leu Lys Gln Ile Ile 
            580                 585                 590         


Arg Asn Ile Lys Phe Lys Ala Pro Pro Cys Asn Thr Phe Val Asp Leu 
        595                 600                 605             


Thr Ser Ala Cys Lys Ile Ser Pro Ala Ser Tyr Asn Lys Glu Glu Ser 
    610                 615                 620                 


Glu Gln Met Gly Lys Thr Ser Arg Lys Asp Met His Cys Leu Glu Ala 
625                 630                 635                 640 


Ser Ser Pro Thr Phe Ser Lys Glu Pro Met Lys Val Gln Asp Ser Val 
                645                 650                 655     


Leu Ile Lys Ala Asp Asn Thr Ile Glu Gly Asp Asn Asn Glu Gln Asn 
            660                 665                 670         


Tyr Ile Lys Asp Val Lys Leu Glu Asp His Leu Leu Ala Gly Ser Cys 
        675                 680                 685             


Leu Lys Gln Ser Ser Lys Asn Ile Phe Thr Glu Arg Ala Glu Asp Gln 
    690                 695                 700                 


Ile Lys Ile Ser Thr Arg Lys Gln Lys Ser Val Lys Glu Ile Ser Ser 
705                 710                 715                 720 


Tyr Thr Pro Lys Asp Cys Thr Ser Arg Asn Gly Pro Glu Arg Gly Cys 
                725                 730                 735     


Asp Arg Gly Ile Ile Val Ser Thr Arg Leu Leu Thr Asp Ser Ser Thr 
            740                 745                 750         


Asp Ala Leu Glu Lys Val Ser Thr Ser Asn Glu Asp Phe Ser Leu Lys 
        755                 760                 765             


Asp Asp Ala Leu Ala Lys Thr Ser Lys Arg Lys Thr Lys Val Gln Lys 
    770                 775                 780                 


Asp Glu Ile Cys Ala Lys Leu Ser His Val Ile Lys Lys Gln His Arg 
785                 790                 795                 800 


Lys Ser Thr Leu Val Asp Asn Thr Ile Asn Leu Asp Glu Asn Leu Thr 
                805                 810                 815     


Val Ser Asn Ile Glu Ser Phe Tyr Ser Arg Lys Asp Thr Gly Val Gln 
            820                 825                 830         


Lys Gly Asp Gly Phe Ile His Asn Leu Ser Leu Asp Pro Ser Gly Val 
        835                 840                 845             


Leu Asp Asp Lys Asn Gly Glu Gln Lys Ser Gln Asn Asn Val Leu Pro 
    850                 855                 860                 


Lys Glu Lys Gln Leu Lys Asn Glu Glu Leu Val Ile Phe Ser Phe His 
865                 870                 875                 880 


Glu Asn Asn Cys Lys Ile Gln Glu Phe His Val Asp Gly Lys Glu Leu 
                885                 890                 895     


Ile Pro Phe Thr Glu Met Thr Asn Ala Ser Glu Lys Lys Ser Ser Pro 
            900                 905                 910         


Phe Lys Asp Leu Met Thr Val Pro Glu Ser Arg Asp Glu Glu Met Ser 
        915                 920                 925             


Asn Ser Thr Ser Val Ile Tyr Ser Asn Leu Thr Arg Glu Gln Ala Pro 
    930                 935                 940                 


Asp Ile Ser Pro Lys Ser Asp Thr Leu Thr Asp Ser Gln Ile Asp Arg 
945                 950                 955                 960 


Asp Leu His Lys Leu Ser Leu Leu Ala Gln Ala Ser Val Ile Thr Phe 
                965                 970                 975     


Pro Ser Asp Ser Pro Gln Asn Ser Ser Gln Leu Gln Arg Lys Val Lys 
            980                 985                 990         


Glu Asp Lys Arg Cys Phe Thr Ala  Asn Gln Asn Asn Val  Gly Asp Thr 
        995                 1000                 1005             


Ser Arg  Gly Gln Val Ile Ile  Ile Ser Asp Ser Asp  Asp Asp Asp 
    1010                 1015                 1020             


Asp Glu  Arg Ile Leu Ser Leu  Glu Lys Leu Thr Lys  Gln Asp Lys 
    1025                 1030                 1035             


Ile Cys  Leu Glu Arg Glu His  Pro Glu Gln His Val  Ser Thr Val 
    1040                 1045                 1050             


Asn Ser  Lys Glu Glu Lys Asn  Pro Val Lys Glu Glu  Lys Thr Glu 
    1055                 1060                 1065             


Thr Leu  Phe Gln Phe Glu Glu  Ser Asp Ser Gln Cys  Phe Glu Phe 
    1070                 1075                 1080             


Glu Ser  Ser Ser Glu Val Phe  Ser Val Trp Gln Asp  His Pro Asp 
    1085                 1090                 1095             


Asp Asn  Asn Ser Val Gln Asp  Gly Glu Lys Lys Cys  Leu Ala Pro 
    1100                 1105                 1110             


Ile Ala  Asn Thr Thr Asn Gly  Gln Gly Cys Thr Asp  Tyr Val Ser 
    1115                 1120                 1125             


Glu Val  Val Lys Lys Gly Ala  Glu Gly Ile Glu Glu  His Thr Arg 
    1130                 1135                 1140             


Pro Arg  Ser Ile Ser Val Glu  Glu Phe Cys Glu Ile  Glu Val Lys 
    1145                 1150                 1155             


Lys Pro  Lys Arg Lys Arg Ser  Glu Lys Pro Met Ala  Glu Asp Pro 
    1160                 1165                 1170             


Val Arg  Pro Ser Ser Ser Val  Arg Asn Glu Gly Gln  Ser Asp Thr 
    1175                 1180                 1185             


Asn Lys  Arg Asp Leu Val Gly  Asn Asp Phe Lys Ser  Ile Asp Arg 
    1190                 1195                 1200             


Arg Thr  Ser Thr Pro Asn Ser  Arg Ile Gln Arg Ala  Thr Thr Val 
    1205                 1210                 1215             


Ser Gln  Lys Lys Ser Ser Lys  Leu Cys Thr Cys Thr  Glu Pro Ile 
    1220                 1225                 1230             


Arg Lys  Val Pro Val Ser Lys  Thr Pro Lys Lys Thr  His Ser Asp 
    1235                 1240                 1245             


Ala Lys  Lys Gly Gln Asn Arg  Ser Ser Asn Tyr Leu  Ser Cys Arg 
    1250                 1255                 1260             


Thr Thr  Pro Ala Ile Val Pro  Pro Lys Lys Phe Arg  Gln Cys Pro 
    1265                 1270                 1275             


Glu Pro  Thr Ser Thr Ala Glu  Lys Leu Gly Leu Lys  Lys Gly Pro 
    1280                 1285                 1290             


Arg Lys  Ala Tyr Glu Leu Ser  Gln Arg Ser Leu Asp  Tyr Val Ala 
    1295                 1300                 1305             


Gln Leu  Arg Asp His Gly Lys  Thr Val Gly Val Val  Asp Thr Arg 
    1310                 1315                 1320             


Lys Lys  Thr Lys Leu Ile Ser  Pro Gln Asn Leu Ser  Val Arg Asn 
    1325                 1330                 1335             


Asn Lys  Lys Leu Leu Thr Ser  Gln Glu Leu Gln Met  Gln Arg Gln 
    1340                 1345                 1350             


Ile Arg  Pro Lys Ser Gln Lys  Asn Arg Arg Arg Leu  Ser Asp Cys 
    1355                 1360                 1365             


Glu Ser  Thr Asp Val Lys Arg  Ala Gly Ser His Thr  Ala Gln Asn 
    1370                 1375                 1380             


Ser Asp  Xaa Phe Val Pro Glu  Ser Asp Arg Ser Asp  Tyr Asn Cys 
    1385                 1390                 1395             


Thr Gly  Gly Thr Glu Val Leu  Ala Asn Ser Asn Arg  Lys Gln Leu 
    1400                 1405                 1410             


Ile Lys  Cys Met Pro Ser Glu  Pro Glu Thr Ile Lys  Ala Lys His 
    1415                 1420                 1425             


Gly Ser  Pro Ala Thr Asp Asp  Ala Cys Pro Leu Asn  Gln Cys Asp 
    1430                 1435                 1440             


Ser Val  Val Leu Asn Gly Thr  Val Pro Thr Asn Glu  Val Ile Val 
    1445                 1450                 1455             


Ser Thr  Ser Glu Asp Pro Leu  Gly Gly Gly Asp Pro  Thr Ala Arg 
    1460                 1465                 1470             


His Ile  Glu Met Ala Ala Leu  Lys Glu Gly Glu Pro  Asp Ser Ser 
    1475                 1480                 1485             


Ser Asp  Ala Glu Glu Asp Asn  Leu Phe Leu Thr Gln  Asn Asp Pro 
    1490                 1495                 1500             


Glu Asp  Met Asp Leu Cys Ser  Gln Met Glu Asn Asp  Asn Tyr Lys 
    1505                 1510                 1515             


Leu Ile  Glu Leu Ile His Gly  Lys Asp Thr Val Glu  Val Glu Glu 
    1520                 1525                 1530             


Asp Ser  Val Ser Arg Pro Gln  Leu Glu Ser Leu Ser  Gly Thr Lys 
    1535                 1540                 1545             


Cys Lys  Tyr Lys Asp Cys Leu  Glu Thr Thr Lys Asn  Gln Gly Glu 
    1550                 1555                 1560             


Tyr Cys  Pro Lys His Ser Glu  Val Lys Ala Ala Asp  Glu Asp Val 
    1565                 1570                 1575             


Phe Arg  Lys Pro Gly Leu Pro  Pro Pro Ala Ser Lys  Pro Leu Arg 
    1580                 1585                 1590             


Pro Thr  Thr Lys Ile Phe Ser  Ser Lys Ser Thr Ser  Arg Ile Ala 
    1595                 1600                 1605             


Gly Leu  Ser Lys Ser Leu Glu  Thr Ser Ser Ala Leu  Ser Pro Ser 
    1610                 1615                 1620             


Leu Lys  Asn Lys Ser Lys Gly  Ile Gln Ser Ile Leu  Lys Val Pro 
    1625                 1630                 1635             


Gln Pro  Val Pro Leu Ile Ala  Gln Lys Pro Val Gly  Glu Met Lys 
    1640                 1645                 1650             


Asn Ser  Cys Asn Val Leu His  Pro Gln Ser Pro Asn  Asn Ser Asn 
    1655                 1660                 1665             


Arg Gln  Gly Cys Lys Val Pro  Phe Gly Glu Ser Lys  Tyr Phe Pro 
    1670                 1675                 1680             


Ser Ser  Ser Pro Val Asn Ile  Leu Leu Ser Ser Gln  Ser Val Ser 
    1685                 1690                 1695             


Asp Thr  Phe Val Lys Glu Val  Leu Lys Trp Lys Tyr  Glu Met Phe 
    1700                 1705                 1710             


Leu Asn  Phe Gly Gln Cys Gly  Pro Pro Ala Ser Leu  Cys Gln Ser 
    1715                 1720                 1725             


Ile Ser  Arg Pro Val Pro Val  Arg Phe His Asn Tyr  Gly Asp Tyr 
    1730                 1735                 1740             


Phe Asn  Val Phe Phe Pro Leu  Met Val Leu Asn Thr  Phe Glu Thr 
    1745                 1750                 1755             


Val Ala  Gln Glu Trp Leu Asn  Ser Pro Asn Arg Glu  Asn Phe Tyr 
    1760                 1765                 1770             


Gln Leu  Gln Val Arg Lys Phe  Pro Ala Asp Tyr Ile  Lys Tyr Trp 
    1775                 1780                 1785             


Glu Phe  Ala Val Tyr Leu Glu  Glu Cys Glu Leu Ala  Lys Gln Leu 
    1790                 1795                 1800             


Tyr Pro  Lys Glu Asn Asp Leu  Val Phe Leu Ala Pro  Glu Arg Ile 
    1805                 1810                 1815             


Asn Glu  Glu Lys Lys Asp Thr  Glu Arg Asn Asp Ile  Gln Asp Leu 
    1820                 1825                 1830             


His Glu  Tyr His Ser Gly Tyr  Val His Lys Phe Arg  Arg Thr Ser 
    1835                 1840                 1845             


Val Met  Arg Asn Gly Lys Thr  Glu Cys Tyr Leu Ser  Ile Gln Thr 
    1850                 1855                 1860             


Gln Glu  Asn Phe Pro Ala Asn  Leu Asn Glu Leu Val  Asn Cys Ile 
    1865                 1870                 1875             


Val Ile  Ser Ser Leu Val Thr  Thr Gln Arg Lys Leu  Lys Ala Met 
    1880                 1885                 1890             


Ser Leu  Leu Gly Ser Arg Asn  Gln Leu Ala Arg Ala  Val Leu Asn 
    1895                 1900                 1905             


Pro Asn  Pro Met Asp Phe Cys  Thr Lys Asp Leu Leu  Thr Thr Thr 
    1910                 1915                 1920             


Ser Glu  Arg Ile Ile Ala Tyr  Leu Arg Asp Phe Asn  Glu Asp Gln 
    1925                 1930                 1935             


Lys Lys  Ala Ile Glu Thr Ala  Tyr Ala Met Val Lys  His Ser Pro 
    1940                 1945                 1950             


Ser Val  Ala Lys Ile Cys Leu  Ile His Gly Pro Pro  Gly Thr Gly 
    1955                 1960                 1965             


Lys Ser  Lys Thr Ile Val Gly  Leu Leu Tyr Arg Leu  Leu Thr Glu 
    1970                 1975                 1980             


Asn Gln  Arg Lys Gly His Ser  Asp Glu Asn Ser Asn  Ala Lys Ile 
    1985                 1990                 1995             


Lys Gln  Asn Arg Val Leu Val  Cys Ala Pro Ser Asn  Ala Ala Val 
    2000                 2005                 2010             


Asp Glu  Leu Met Lys Lys Ile  Ile Leu Glu Phe Lys  Glu Lys Cys 
    2015                 2020                 2025             


Lys Asp  Lys Lys Asn Pro Leu  Gly Asn Cys Gly Asp  Ile Asn Leu 
    2030                 2035                 2040             


Val Arg  Leu Gly Pro Glu Lys  Ser Ile Asn Ser Glu  Val Leu Lys 
    2045                 2050                 2055             


Phe Ser  Leu Asp Ser Gln Val  Asn His Arg Met Lys  Lys Glu Leu 
    2060                 2065                 2070             


Pro Ser  His Val Gln Ala Met  His Lys Arg Lys Glu  Phe Leu Asp 
    2075                 2080                 2085             


Tyr Gln  Leu Asp Glu Leu Ser  Arg Gln Arg Ala Leu  Cys Arg Gly 
    2090                 2095                 2100             


Gly Arg  Glu Ile Gln Arg Gln  Glu Leu Asp Glu Asn  Ile Ser Lys 
    2105                 2110                 2115             


Val Ser  Lys Glu Arg Gln Glu  Leu Ala Ser Lys Ile  Lys Glu Val 
    2120                 2125                 2130             


Gln Gly  Arg Pro Gln Lys Thr  Gln Ser Ile Ile Ile  Leu Glu Ser 
    2135                 2140                 2145             


His Ile  Ile Cys Cys Thr Leu  Ser Thr Ser Gly Gly  Leu Leu Leu 
    2150                 2155                 2160             


Glu Ser  Ala Phe Arg Gly Gln  Gly Gly Val Pro Phe  Ser Cys Val 
    2165                 2170                 2175             


Ile Val  Asp Glu Ala Gly Gln  Ser Cys Glu Ile Glu  Thr Leu Thr 
    2180                 2185                 2190             


Pro Leu  Ile His Arg Cys Asn  Lys Leu Ile Leu Val  Gly Asp Pro 
    2195                 2200                 2205             


Lys Gln  Leu Pro Pro Thr Val  Ile Ser Met Lys Ala  Gln Glu Tyr 
    2210                 2215                 2220             


Gly Tyr  Asp Gln Ser Met Met  Ala Arg Phe Cys Arg  Leu Leu Glu 
    2225                 2230                 2235             


Glu Asn  Val Glu His Asn Met  Ile Ser Arg Leu Pro  Ile Leu Gln 
    2240                 2245                 2250             


Leu Thr  Val Gln Tyr Arg Met  His Pro Asp Ile Cys  Leu Phe Pro 
    2255                 2260                 2265             


Ser Asn  Tyr Val Tyr Asn Arg  Asn Leu Lys Thr Asn  Arg Gln Thr 
    2270                 2275                 2280             


Glu Ala  Ile Arg Cys Ser Ser  Asp Trp Pro Phe Gln  Pro Tyr Leu 
    2285                 2290                 2295             


Val Phe  Asp Val Gly Asp Gly  Ser Glu Arg Arg Asp  Asn Asp Ser 
    2300                 2305                 2310             


Tyr Ile  Asn Val Gln Glu Ile  Lys Leu Val Met Glu  Ile Ile Lys 
    2315                 2320                 2325             


Leu Ile  Lys Asp Lys Arg Lys  Asp Val Ser Phe Arg  Asn Ile Gly 
    2330                 2335                 2340             


Ile Ile  Thr His Tyr Lys Ala  Gln Lys Thr Met Ile  Gln Lys Asp 
    2345                 2350                 2355             


Leu Asp  Lys Glu Phe Asp Arg  Lys Gly Pro Ala Glu  Val Asp Thr 
    2360                 2365                 2370             


Val Asp  Ala Phe Gln Gly Arg  Gln Lys Asp Cys Val  Ile Val Thr 
    2375                 2380                 2385             


Cys Val  Arg Ala Asn Ser Ile  Gln Gly Ser Ile Gly  Phe Leu Ala 
    2390                 2395                 2400             


Ser Leu  Gln Arg Leu Asn Val  Thr Ile Thr Arg Ala  Lys Tyr Ser 
    2405                 2410                 2415             


Leu Phe  Ile Leu Gly His Leu  Arg Thr Leu Met Glu  Asn Gln His 
    2420                 2425                 2430             


Trp Asn  Gln Leu Ile Gln Asp  Ala Gln Lys Arg Gly  Ala Ile Ile 
    2435                 2440                 2445             


Lys Thr  Cys Asp Lys Asn Tyr  Arg His Asp Ala Val  Lys Ile Leu 
    2450                 2455                 2460             


Lys Leu  Lys Pro Val Leu Gln  Arg Ser Leu Thr His  Pro Pro Thr 
    2465                 2470                 2475             


Ile Ala  Pro Glu Gly Ser Arg  Pro Gln Gly Gly Leu  Pro Ser Ser 
    2480                 2485                 2490             


Lys Leu  Asp Ser Gly Phe Ala  Lys Thr Ser Val Ala  Ala Ser Leu 
    2495                 2500                 2505             


Tyr His  Thr Pro Ser Asp Ser  Lys Glu Ile Thr Leu  Thr Val Thr 
    2510                 2515                 2520             


Ser Lys  Asp Pro Glu Arg Pro  Pro Val His Asp Gln  Leu Gln Asp 
    2525                 2530                 2535             


Pro Arg  Leu Leu Lys Arg Met  Gly Ile Glu Val Lys  Gly Gly Ile 
    2540                 2545                 2550             


Phe Leu  Trp Asp Pro Gln Pro  Ser Ser Pro Gln His  Pro Gly Ala 
    2555                 2560                 2565             


Thr Pro  Pro Thr Gly Glu Pro  Gly Phe Pro Val Val  His Gln Asp 
    2570                 2575                 2580             


Leu Ser  His Ile Gln Gln Pro  Ala Ala Val Val Ala  Ala Leu Ser 
    2585                 2590                 2595             


Ser His  Lys Pro Pro Val Arg  Gly Glu Pro Pro Ala  Ala Ser Pro 
    2600                 2605                 2610             


Glu Ala  Ser Thr Cys Gln Ser  Lys Cys Asp Asp Pro  Glu Glu Glu 
    2615                 2620                 2625             


Leu Cys  His Arg Arg Glu Ala  Arg Ala Phe Ser Glu  Gly Glu Gln 
    2630                 2635                 2640             


Glu Lys  Cys Gly Ser Glu Thr  His His Thr Arg Arg  Asn Ser Arg 
    2645                 2650                 2655             


Trp Asp  Lys Arg Thr Leu Glu  Gln Glu Asp Ser Ser  Ser Lys Lys 
    2660                 2665                 2670             


Arg Lys  Leu Leu 
    2675         


<210>  23
<211>  4952
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (244)..(3480)
<223>  

<400>  23
ggcacgaggc tgagcactcc gcagctgggt gcgcacggga gcctcaaccg cggcgcgtgg     60

aggcagtacc agagcgcgcg gcgcgcagtc ggccggcagc cgcgggacag ccttggcaga    120

acagccgcgg cgggagcccc gcagccccgg gctgggcccg cgtcccggag cgccaccgga    180

gagcgaggac gacgtggagg cggagtggcg cccggcgagg tagcgccagg cgagctggag    240

acc atg gcc aaa atg gag gtg aaa acc tca ctt ctg gac aat atg att      288
    Met Ala Lys Met Glu Val Lys Thr Ser Leu Leu Asp Asn Met Ile         
    1               5                   10                  15          

gga gtt ggg gat atg gtt ctt tta gaa cct ctc aat gag gag acc ttc      336
Gly Val Gly Asp Met Val Leu Leu Glu Pro Leu Asn Glu Glu Thr Phe         
                20                  25                  30              

atc aac aac ctc aag aag cgc ttt gac cac agt gaa ata tac aca tac      384
Ile Asn Asn Leu Lys Lys Arg Phe Asp His Ser Glu Ile Tyr Thr Tyr         
            35                  40                  45                  

att gga agt gtg gtt ata tct gtt aac cca tac cgg tct tta ccc att      432
Ile Gly Ser Val Val Ile Ser Val Asn Pro Tyr Arg Ser Leu Pro Ile         
        50                  55                  60                      

tat tca cca gag aaa gtg gaa gaa tac agg aac aga aat ttt tat gaa      480
Tyr Ser Pro Glu Lys Val Glu Glu Tyr Arg Asn Arg Asn Phe Tyr Glu         
    65                  70                  75                          

ctg agc cct cac atc ttt gcc ctt tcg gat gaa gca tac aga tcc cta      528
Leu Ser Pro His Ile Phe Ala Leu Ser Asp Glu Ala Tyr Arg Ser Leu         
80                  85                  90                  95          

cga gat caa gat aag gac caa tgt att ctc att act ggg gaa agt gga      576
Arg Asp Gln Asp Lys Asp Gln Cys Ile Leu Ile Thr Gly Glu Ser Gly         
                100                 105                 110             

gca gga aaa aca gag gcc agt aag ctt gtc atg tcc tat gtg gca gct      624
Ala Gly Lys Thr Glu Ala Ser Lys Leu Val Met Ser Tyr Val Ala Ala         
            115                 120                 125                 

gtt tgt gga aaa gga gca gaa gtt aat caa gtt aaa gaa cag ctt tta      672
Val Cys Gly Lys Gly Ala Glu Val Asn Gln Val Lys Glu Gln Leu Leu         
        130                 135                 140                     

cag tcc aac ccg gtc ctg gaa gct ttt gga aat gcc aaa act gta agg      720
Gln Ser Asn Pro Val Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg         
    145                 150                 155                         

aat gac aac tcc tct aga ttt ggc aaa tat atg gat att gaa ttt gac      768
Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Met Asp Ile Glu Phe Asp         
160                 165                 170                 175         

ttt aaa ggc gat cca cta gga gga gta ata agt aac tat ctt tta gag      816
Phe Lys Gly Asp Pro Leu Gly Gly Val Ile Ser Asn Tyr Leu Leu Glu         
                180                 185                 190             

aaa tct cgg gtt gtt aaa cag cca aga ggt gaa aga aac ttc cat gtg      864
Lys Ser Arg Val Val Lys Gln Pro Arg Gly Glu Arg Asn Phe His Val         
            195                 200                 205                 

ttc tat cag ctg ctc tct ggt gcc tct gaa gag ctc ctc aat aaa ctt      912
Phe Tyr Gln Leu Leu Ser Gly Ala Ser Glu Glu Leu Leu Asn Lys Leu         
        210                 215                 220                     

aag ctt gag agg gat ttc agc agg tat aac tac ctg agt ctg gat tcg      960
Lys Leu Glu Arg Asp Phe Ser Arg Tyr Asn Tyr Leu Ser Leu Asp Ser         
    225                 230                 235                         

gcc aaa gtg aat gga gtg gat gat gca gca aat ttt aga acc gtg cgg     1008
Ala Lys Val Asn Gly Val Asp Asp Ala Ala Asn Phe Arg Thr Val Arg         
240                 245                 250                 255         

aat gcc atg cag att gtg ggc ttt atg gat cat gaa gct gag tct gtc     1056
Asn Ala Met Gln Ile Val Gly Phe Met Asp His Glu Ala Glu Ser Val         
                260                 265                 270             

ttg gcg gtg gtg gca gca gtg ttg aaa ctg ggg aac att gag ttc aag     1104
Leu Ala Val Val Ala Ala Val Leu Lys Leu Gly Asn Ile Glu Phe Lys         
            275                 280                 285                 

ccc gaa tct cga gtg aat ggt cta gat gaa agc aaa atc aaa gat aaa     1152
Pro Glu Ser Arg Val Asn Gly Leu Asp Glu Ser Lys Ile Lys Asp Lys         
        290                 295                 300                     

aat gag tta aaa gaa att tgt gaa ttg acc ggc att gat caa tca gtt     1200
Asn Glu Leu Lys Glu Ile Cys Glu Leu Thr Gly Ile Asp Gln Ser Val         
    305                 310                 315                         

cta gaa cga gca ttc agt ttc cga aca gtt gag gcc aaa cag gag aaa     1248
Leu Glu Arg Ala Phe Ser Phe Arg Thr Val Glu Ala Lys Gln Glu Lys         
320                 325                 330                 335         

gtt tca act aca ctg aat gtg gct cag gct tat tat gcc cgt gat gct     1296
Val Ser Thr Thr Leu Asn Val Ala Gln Ala Tyr Tyr Ala Arg Asp Ala         
                340                 345                 350             

ctg gct aaa aac ctc tac agc agg ttg ttt tca tgg ttg gta aat cga     1344
Leu Ala Lys Asn Leu Tyr Ser Arg Leu Phe Ser Trp Leu Val Asn Arg         
            355                 360                 365                 

atc aat gaa agc att aag gca caa aca aaa gtg aga aag aag gtc atg     1392
Ile Asn Glu Ser Ile Lys Ala Gln Thr Lys Val Arg Lys Lys Val Met         
        370                 375                 380                     

ggt gtt ctg gac att tat ggc ttt gag att ttc gag gac aac agc ttt     1440
Gly Val Leu Asp Ile Tyr Gly Phe Glu Ile Phe Glu Asp Asn Ser Phe         
    385                 390                 395                         

gag cag ttc att att aat tat tgt aac gaa aag ctg caa caa atc ttc     1488
Glu Gln Phe Ile Ile Asn Tyr Cys Asn Glu Lys Leu Gln Gln Ile Phe         
400                 405                 410                 415         

att gaa ctt act ctt aaa gaa gag cag gag gag tat ata cgg gag gat     1536
Ile Glu Leu Thr Leu Lys Glu Glu Gln Glu Glu Tyr Ile Arg Glu Asp         
                420                 425                 430             

ata gaa tgg act cac att gac tac ttc aat aat gct atc att tgt gac     1584
Ile Glu Trp Thr His Ile Asp Tyr Phe Asn Asn Ala Ile Ile Cys Asp         
            435                 440                 445                 

cta ata gaa aat aac aca aat gga atc ctg gcc atg ctg gat gaa gag     1632
Leu Ile Glu Asn Asn Thr Asn Gly Ile Leu Ala Met Leu Asp Glu Glu         
        450                 455                 460                     

tgc ctc aga cct ggc aca gtc act gat gag acc ttc tta gaa aag ctg     1680
Cys Leu Arg Pro Gly Thr Val Thr Asp Glu Thr Phe Leu Glu Lys Leu         
    465                 470                 475                         

aac caa gta tgt gcc acc cac cag cat ttt gaa agc agg atg agc aag     1728
Asn Gln Val Cys Ala Thr His Gln His Phe Glu Ser Arg Met Ser Lys         
480                 485                 490                 495         

tgc tct cgg ttc ctc aat gac acg tct ctg cct cac agc tgc ttc agg     1776
Cys Ser Arg Phe Leu Asn Asp Thr Ser Leu Pro His Ser Cys Phe Arg         
                500                 505                 510             

atc cag cat tat gct gga aag gtg ctg tac cag gtg gaa gga ttc gtt     1824
Ile Gln His Tyr Ala Gly Lys Val Leu Tyr Gln Val Glu Gly Phe Val         
            515                 520                 525                 

gac aaa aac aat gac ctt ctc tat cga gac ctg tcc caa gcc atg tgg     1872
Asp Lys Asn Asn Asp Leu Leu Tyr Arg Asp Leu Ser Gln Ala Met Trp         
        530                 535                 540                     

aag gcc agc cat gcc ctc atc aag tct ttg ttc ccc gaa ggg aat ccc     1920
Lys Ala Ser His Ala Leu Ile Lys Ser Leu Phe Pro Glu Gly Asn Pro         
    545                 550                 555                         

gcc aag atc aac ctg aaa agg cct cct aca gca ggc tca cag ttc aag     1968
Ala Lys Ile Asn Leu Lys Arg Pro Pro Thr Ala Gly Ser Gln Phe Lys         
560                 565                 570                 575         

gca tcc gtg gcc act ctg atg aaa aac cta cag acc aag aac cca aac     2016
Ala Ser Val Ala Thr Leu Met Lys Asn Leu Gln Thr Lys Asn Pro Asn         
                580                 585                 590             

tat att agg tgt atc aaa ccg aat gat aaa aaa gca gca cac atc ttc     2064
Tyr Ile Arg Cys Ile Lys Pro Asn Asp Lys Lys Ala Ala His Ile Phe         
            595                 600                 605                 

aac gag gct cta gtg tgt cat cag atc agg tac ctg ggg ctt ttg gag     2112
Asn Glu Ala Leu Val Cys His Gln Ile Arg Tyr Leu Gly Leu Leu Glu         
        610                 615                 620                     

aac gtc cga gtg cgg agg gca ggc tac gcc ttc agg cag gcc tat gaa     2160
Asn Val Arg Val Arg Arg Ala Gly Tyr Ala Phe Arg Gln Ala Tyr Glu         
    625                 630                 635                         

cct tgc cta gaa aga tac aaa atg ctt tgt aaa caa aca tgg cct cat     2208
Pro Cys Leu Glu Arg Tyr Lys Met Leu Cys Lys Gln Thr Trp Pro His         
640                 645                 650                 655         

tgg aaa gga cca gcc agg tct ggt gtg gag gtc cta ttt aat gaa tta     2256
Trp Lys Gly Pro Ala Arg Ser Gly Val Glu Val Leu Phe Asn Glu Leu         
                660                 665                 670             

gaa att ccc gtg gaa gaa tac tcc ttt ggt aga tca aag ata ttc atc     2304
Glu Ile Pro Val Glu Glu Tyr Ser Phe Gly Arg Ser Lys Ile Phe Ile         
            675                 680                 685                 

cga aac cca aga aca tta ttc aaa tta gaa gac ctg agg aag caa cgc     2352
Arg Asn Pro Arg Thr Leu Phe Lys Leu Glu Asp Leu Arg Lys Gln Arg         
        690                 695                 700                     

ctg gag gac ttg gcc act ctc att cag aag ata tat cgg ggg tgg aaa     2400
Leu Glu Asp Leu Ala Thr Leu Ile Gln Lys Ile Tyr Arg Gly Trp Lys         
    705                 710                 715                         

tgc cgc aca cac ttc ctg cta atg aaa aaa agc caa att gtg att gcc     2448
Cys Arg Thr His Phe Leu Leu Met Lys Lys Ser Gln Ile Val Ile Ala         
720                 725                 730                 735         

gcc tgg tac agg aga tat gcg caa caa aag agg tac cag cag aca aag     2496
Ala Trp Tyr Arg Arg Tyr Ala Gln Gln Lys Arg Tyr Gln Gln Thr Lys         
                740                 745                 750             

agt tcc gcc tta gta att cag tct tat atc cgg ggt tgg aag gct cga     2544
Ser Ser Ala Leu Val Ile Gln Ser Tyr Ile Arg Gly Trp Lys Ala Arg         
            755                 760                 765                 

aaa att ctg cgg gaa ctg aag cat caa aag cgc tgt aag gaa gca gtc     2592
Lys Ile Leu Arg Glu Leu Lys His Gln Lys Arg Cys Lys Glu Ala Val         
        770                 775                 780                     

acg acc att gct gca tat tgg cat ggg acc cag gta cgt aga gaa tac     2640
Thr Thr Ile Ala Ala Tyr Trp His Gly Thr Gln Val Arg Arg Glu Tyr         
    785                 790                 795                         

agg aaa ttc ttc aga gcc aat gct gga aag aaa atc tat gag ttt acg     2688
Arg Lys Phe Phe Arg Ala Asn Ala Gly Lys Lys Ile Tyr Glu Phe Thr         
800                 805                 810                 815         

ctt cag aga att gtg caa aaa tac ttc ttg gaa atg aaa aat aag atg     2736
Leu Gln Arg Ile Val Gln Lys Tyr Phe Leu Glu Met Lys Asn Lys Met         
                820                 825                 830             

cct tcc tta tct cca ata gac aag aat tgg ccc tca aga cct tac tta     2784
Pro Ser Leu Ser Pro Ile Asp Lys Asn Trp Pro Ser Arg Pro Tyr Leu         
            835                 840                 845                 

ttc ttg gat tct act cac aag gag cta aaa agg att ttc cac ttg tgg     2832
Phe Leu Asp Ser Thr His Lys Glu Leu Lys Arg Ile Phe His Leu Trp         
        850                 855                 860                     

agg tgt aaa aaa tac agg gac caa ttc aca gac cag cag aaa ctt att     2880
Arg Cys Lys Lys Tyr Arg Asp Gln Phe Thr Asp Gln Gln Lys Leu Ile         
    865                 870                 875                         

tat gaa gag aaa cta gaa gcc agt gaa ctc ttc aaa gac aag aag gct     2928
Tyr Glu Glu Lys Leu Glu Ala Ser Glu Leu Phe Lys Asp Lys Lys Ala         
880                 885                 890                 895         

tta tac cca tct agt gtt ggg caa cca ttc caa ggg gct tac ctg gaa     2976
Leu Tyr Pro Ser Ser Val Gly Gln Pro Phe Gln Gly Ala Tyr Leu Glu         
                900                 905                 910             

atc aac aag aac ccc aag tat aag aaa ctc aaa gat gcc att gaa gaa     3024
Ile Asn Lys Asn Pro Lys Tyr Lys Lys Leu Lys Asp Ala Ile Glu Glu         
            915                 920                 925                 

aag atc atc att gct gaa gtc gtg aac aaa att aac cgt gct aat ggg     3072
Lys Ile Ile Ile Ala Glu Val Val Asn Lys Ile Asn Arg Ala Asn Gly         
        930                 935                 940                     

aag agt aca tct cgg att ttc ctc tta aca aac aat aat ctc ctt ctt     3120
Lys Ser Thr Ser Arg Ile Phe Leu Leu Thr Asn Asn Asn Leu Leu Leu         
    945                 950                 955                         

gct gac caa aag tct gga caa atc aag tca gag gtt cca ctg gtg gat     3168
Ala Asp Gln Lys Ser Gly Gln Ile Lys Ser Glu Val Pro Leu Val Asp         
960                 965                 970                 975         

gtg acc aag gta tca atg agc tca caa aat gat ggc ttc ttc gcc gtc     3216
Val Thr Lys Val Ser Met Ser Ser Gln Asn Asp Gly Phe Phe Ala Val         
                980                 985                 990             

cac ctc aaa gag ggc tca gaa gca gct  agt aaa gga gac ttt  ctc ttc   3264
His Leu Lys Glu Gly Ser Glu Ala Ala  Ser Lys Gly Asp Phe  Leu Phe       
            995                 1000                 1005               

agc agt gat  cac ctg att gaa atg  gcc acc aag ctc tat  cgc aca      3309
Ser Ser Asp  His Leu Ile Glu Met  Ala Thr Lys Leu Tyr  Arg Thr          
        1010                 1015                 1020                  

act ctc agc  caa acc aaa cag aag  ctc aat att gag att  tcc gat      3354
Thr Leu Ser  Gln Thr Lys Gln Lys  Leu Asn Ile Glu Ile  Ser Asp          
        1025                 1030                 1035                  

gag ttc ctg  gta cag ttc aga cag  gac aaa gta tgt gtg  aag ttt      3399
Glu Phe Leu  Val Gln Phe Arg Gln  Asp Lys Val Cys Val  Lys Phe          
        1040                 1045                 1050                  

att cag gga  aac cag aaa aat ggg  agt gtc cca aca tgt  aaa cga      3444
Ile Gln Gly  Asn Gln Lys Asn Gly  Ser Val Pro Thr Cys  Lys Arg          
        1055                 1060                 1065                  

aaa aac aac  cgt ctc ctt gaa gtt  gct gtc cct taa ctggcgcctc        3490
Lys Asn Asn  Arg Leu Leu Glu Val  Ala Val Pro                           
        1070                 1075                                       

ctctctactt tcatggactt gttcctttgt aatagtgcaa tttggttttg ttttatttgg   3550

ggttcattgt atgtttggga atcaccaaag gcttttagag ttctttggca aaataaaaat   3610

atttgactaa tcaattttta ttattggaat agttttaacc tttcaaatac atgttctgtc   3670

ctggagcagg attgtagaaa ctaacagtgt ctattttcat gtctgatgtg ttcttccttt   3730

agtcatcatg ttaggtctgt gtaccctaaa tcagcatatt actcataaat cattaattaa   3790

tataagcata ggaaatggtc ttaaaagata ctgcattcat tcatcagata tttattccat   3850

gcctactcta tgctaggcac tgtgctagat ggtatgaaaa cttattagga acctttttgt   3910

ttttgagacc attgcattct ggctggtttg tgctggttta acgacatcta agaaggttta   3970

gaaatggtga gaccaaaaca ataactgtta atgatggaca gcattattag gaaccctgta   4030

gtatgatatt taacaatata ggcttcaaga agggctggtc ctaagagggg gcagaaatga   4090

atgaccaggt taaatccctc tacatgtggt ttctgtttga aaaaaagaaa actgacattt   4150

gaacaggact tttaatttgt ttaaaactct ggtaattact tgtaacagta gaaaatagaa   4210

gtcattctta ttttagaaaa agtgacagaa gcagtccagt aagattatat gtttctgttt   4270

ctggtaaata ccatatatga tcctcgaaat gataatatct ccagaatatt gttttcaccc   4330

aaatttgagt agatatttta aacacctaac aaagtaaagg gctaaaagcc attcagatag   4390

cagtaaaaca ttctgtatga tgtgcaataa aacatccaag atcttttttg aaagttttat   4450

ttataatata catttttgta tgagaaaggt gattggtaca gggtgcctat tttagtcatg   4510

gatcaaaatt tgtgtaactt gcagggcttt ctttcttttt cttcaaattt acaagggttc   4570

attttggaaa ctacatttta aactttggaa tcaaattgtt tcttatttgg gaggataatg   4630

tatatacatt ggtattatgt taaataataa aattgttcta atttggtgcc atttcctgaa   4690

tcacaactgt atttttgtat ctcaagctat tttcatatgt tatgtgtcaa tgtatcatct   4750

ctcagaaagg ttttacaatc caaacattat atgttctctg tgtaactgaa tttcacttat   4810

cttttataaa ccagaaacat taattgaaaa tattttctgg ggattttctc ttgacttgta   4870

tttttaaaaa ttgctcacat aaagaagttc tcagaaaaaa aaaaaaaaaa aaaaaaaaaa   4930

aaaaaaaaaa aaaaaaaaaa aa                                            4952


<210>  24
<211>  1078
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Lys Met Glu Val Lys Thr Ser Leu Leu Asp Asn Met Ile Gly 
1               5                   10                  15      


Val Gly Asp Met Val Leu Leu Glu Pro Leu Asn Glu Glu Thr Phe Ile 
            20                  25                  30          


Asn Asn Leu Lys Lys Arg Phe Asp His Ser Glu Ile Tyr Thr Tyr Ile 
        35                  40                  45              


Gly Ser Val Val Ile Ser Val Asn Pro Tyr Arg Ser Leu Pro Ile Tyr 
    50                  55                  60                  


Ser Pro Glu Lys Val Glu Glu Tyr Arg Asn Arg Asn Phe Tyr Glu Leu 
65                  70                  75                  80  


Ser Pro His Ile Phe Ala Leu Ser Asp Glu Ala Tyr Arg Ser Leu Arg 
                85                  90                  95      


Asp Gln Asp Lys Asp Gln Cys Ile Leu Ile Thr Gly Glu Ser Gly Ala 
            100                 105                 110         


Gly Lys Thr Glu Ala Ser Lys Leu Val Met Ser Tyr Val Ala Ala Val 
        115                 120                 125             


Cys Gly Lys Gly Ala Glu Val Asn Gln Val Lys Glu Gln Leu Leu Gln 
    130                 135                 140                 


Ser Asn Pro Val Leu Glu Ala Phe Gly Asn Ala Lys Thr Val Arg Asn 
145                 150                 155                 160 


Asp Asn Ser Ser Arg Phe Gly Lys Tyr Met Asp Ile Glu Phe Asp Phe 
                165                 170                 175     


Lys Gly Asp Pro Leu Gly Gly Val Ile Ser Asn Tyr Leu Leu Glu Lys 
            180                 185                 190         


Ser Arg Val Val Lys Gln Pro Arg Gly Glu Arg Asn Phe His Val Phe 
        195                 200                 205             


Tyr Gln Leu Leu Ser Gly Ala Ser Glu Glu Leu Leu Asn Lys Leu Lys 
    210                 215                 220                 


Leu Glu Arg Asp Phe Ser Arg Tyr Asn Tyr Leu Ser Leu Asp Ser Ala 
225                 230                 235                 240 


Lys Val Asn Gly Val Asp Asp Ala Ala Asn Phe Arg Thr Val Arg Asn 
                245                 250                 255     


Ala Met Gln Ile Val Gly Phe Met Asp His Glu Ala Glu Ser Val Leu 
            260                 265                 270         


Ala Val Val Ala Ala Val Leu Lys Leu Gly Asn Ile Glu Phe Lys Pro 
        275                 280                 285             


Glu Ser Arg Val Asn Gly Leu Asp Glu Ser Lys Ile Lys Asp Lys Asn 
    290                 295                 300                 


Glu Leu Lys Glu Ile Cys Glu Leu Thr Gly Ile Asp Gln Ser Val Leu 
305                 310                 315                 320 


Glu Arg Ala Phe Ser Phe Arg Thr Val Glu Ala Lys Gln Glu Lys Val 
                325                 330                 335     


Ser Thr Thr Leu Asn Val Ala Gln Ala Tyr Tyr Ala Arg Asp Ala Leu 
            340                 345                 350         


Ala Lys Asn Leu Tyr Ser Arg Leu Phe Ser Trp Leu Val Asn Arg Ile 
        355                 360                 365             


Asn Glu Ser Ile Lys Ala Gln Thr Lys Val Arg Lys Lys Val Met Gly 
    370                 375                 380                 


Val Leu Asp Ile Tyr Gly Phe Glu Ile Phe Glu Asp Asn Ser Phe Glu 
385                 390                 395                 400 


Gln Phe Ile Ile Asn Tyr Cys Asn Glu Lys Leu Gln Gln Ile Phe Ile 
                405                 410                 415     


Glu Leu Thr Leu Lys Glu Glu Gln Glu Glu Tyr Ile Arg Glu Asp Ile 
            420                 425                 430         


Glu Trp Thr His Ile Asp Tyr Phe Asn Asn Ala Ile Ile Cys Asp Leu 
        435                 440                 445             


Ile Glu Asn Asn Thr Asn Gly Ile Leu Ala Met Leu Asp Glu Glu Cys 
    450                 455                 460                 


Leu Arg Pro Gly Thr Val Thr Asp Glu Thr Phe Leu Glu Lys Leu Asn 
465                 470                 475                 480 


Gln Val Cys Ala Thr His Gln His Phe Glu Ser Arg Met Ser Lys Cys 
                485                 490                 495     


Ser Arg Phe Leu Asn Asp Thr Ser Leu Pro His Ser Cys Phe Arg Ile 
            500                 505                 510         


Gln His Tyr Ala Gly Lys Val Leu Tyr Gln Val Glu Gly Phe Val Asp 
        515                 520                 525             


Lys Asn Asn Asp Leu Leu Tyr Arg Asp Leu Ser Gln Ala Met Trp Lys 
    530                 535                 540                 


Ala Ser His Ala Leu Ile Lys Ser Leu Phe Pro Glu Gly Asn Pro Ala 
545                 550                 555                 560 


Lys Ile Asn Leu Lys Arg Pro Pro Thr Ala Gly Ser Gln Phe Lys Ala 
                565                 570                 575     


Ser Val Ala Thr Leu Met Lys Asn Leu Gln Thr Lys Asn Pro Asn Tyr 
            580                 585                 590         


Ile Arg Cys Ile Lys Pro Asn Asp Lys Lys Ala Ala His Ile Phe Asn 
        595                 600                 605             


Glu Ala Leu Val Cys His Gln Ile Arg Tyr Leu Gly Leu Leu Glu Asn 
    610                 615                 620                 


Val Arg Val Arg Arg Ala Gly Tyr Ala Phe Arg Gln Ala Tyr Glu Pro 
625                 630                 635                 640 


Cys Leu Glu Arg Tyr Lys Met Leu Cys Lys Gln Thr Trp Pro His Trp 
                645                 650                 655     


Lys Gly Pro Ala Arg Ser Gly Val Glu Val Leu Phe Asn Glu Leu Glu 
            660                 665                 670         


Ile Pro Val Glu Glu Tyr Ser Phe Gly Arg Ser Lys Ile Phe Ile Arg 
        675                 680                 685             


Asn Pro Arg Thr Leu Phe Lys Leu Glu Asp Leu Arg Lys Gln Arg Leu 
    690                 695                 700                 


Glu Asp Leu Ala Thr Leu Ile Gln Lys Ile Tyr Arg Gly Trp Lys Cys 
705                 710                 715                 720 


Arg Thr His Phe Leu Leu Met Lys Lys Ser Gln Ile Val Ile Ala Ala 
                725                 730                 735     


Trp Tyr Arg Arg Tyr Ala Gln Gln Lys Arg Tyr Gln Gln Thr Lys Ser 
            740                 745                 750         


Ser Ala Leu Val Ile Gln Ser Tyr Ile Arg Gly Trp Lys Ala Arg Lys 
        755                 760                 765             


Ile Leu Arg Glu Leu Lys His Gln Lys Arg Cys Lys Glu Ala Val Thr 
    770                 775                 780                 


Thr Ile Ala Ala Tyr Trp His Gly Thr Gln Val Arg Arg Glu Tyr Arg 
785                 790                 795                 800 


Lys Phe Phe Arg Ala Asn Ala Gly Lys Lys Ile Tyr Glu Phe Thr Leu 
                805                 810                 815     


Gln Arg Ile Val Gln Lys Tyr Phe Leu Glu Met Lys Asn Lys Met Pro 
            820                 825                 830         


Ser Leu Ser Pro Ile Asp Lys Asn Trp Pro Ser Arg Pro Tyr Leu Phe 
        835                 840                 845             


Leu Asp Ser Thr His Lys Glu Leu Lys Arg Ile Phe His Leu Trp Arg 
    850                 855                 860                 


Cys Lys Lys Tyr Arg Asp Gln Phe Thr Asp Gln Gln Lys Leu Ile Tyr 
865                 870                 875                 880 


Glu Glu Lys Leu Glu Ala Ser Glu Leu Phe Lys Asp Lys Lys Ala Leu 
                885                 890                 895     


Tyr Pro Ser Ser Val Gly Gln Pro Phe Gln Gly Ala Tyr Leu Glu Ile 
            900                 905                 910         


Asn Lys Asn Pro Lys Tyr Lys Lys Leu Lys Asp Ala Ile Glu Glu Lys 
        915                 920                 925             


Ile Ile Ile Ala Glu Val Val Asn Lys Ile Asn Arg Ala Asn Gly Lys 
    930                 935                 940                 


Ser Thr Ser Arg Ile Phe Leu Leu Thr Asn Asn Asn Leu Leu Leu Ala 
945                 950                 955                 960 


Asp Gln Lys Ser Gly Gln Ile Lys Ser Glu Val Pro Leu Val Asp Val 
                965                 970                 975     


Thr Lys Val Ser Met Ser Ser Gln Asn Asp Gly Phe Phe Ala Val His 
            980                 985                 990         


Leu Lys Glu Gly Ser Glu Ala Ala  Ser Lys Gly Asp Phe  Leu Phe Ser 
        995                 1000                 1005             


Ser Asp  His Leu Ile Glu Met  Ala Thr Lys Leu Tyr  Arg Thr Thr 
    1010                 1015                 1020             


Leu Ser  Gln Thr Lys Gln Lys  Leu Asn Ile Glu Ile  Ser Asp Glu 
    1025                 1030                 1035             


Phe Leu  Val Gln Phe Arg Gln  Asp Lys Val Cys Val  Lys Phe Ile 
    1040                 1045                 1050             


Gln Gly  Asn Gln Lys Asn Gly  Ser Val Pro Thr Cys  Lys Arg Lys 
    1055                 1060                 1065             


Asn Asn  Arg Leu Leu Glu Val  Ala Val Pro 
    1070                 1075             


<210>  25
<211>  6545
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (617)..(3052)
<223>  

<400>  25
ataaatctgt agttctcagt aatattcttg aaaatggtaa atgatcaaat actttggaga     60

ccattggtct aaaattactc tataacccat ttccttggct ttttttctca agacagcacc    120

aggccatctc ctgtgctgtc tgccattttg ttgatgtgtg cagtgtgttg gaggccctca    180

cctttgcttg tatcatggcc ctatgcttat gaagaacgta atagagtgtt tttcataatt    240

caaccaacag ctgtacttcc tcagttaagc tcaaaacaga gccaactttg ctcctaatgt    300

tagtctactg tgtttgtact ttcaccttag tacttgtaac atattaccac acatattttc    360

ttaccactct gtgtgttctt tgaacacagg aagattttta ttaatcttag tatttccagc    420

agtgatgata gttccaggta ctttgtagga acttgataat ttcttttgca tgaattaata    480

tcttaatgca ttaatggcag aatatttctg ttatgatttc tttttcccta aaagtataaa    540

acaaaacaat attctgtgaa taataatcat ggtaaggatt agcccatact tcttttttca    600

tgccacctaa ttctga atg ttt cag gta gaa cag aag tcc cag gag tca gta    652
                  Met Phe Gln Val Glu Gln Lys Ser Gln Glu Ser Val       
                  1               5                   10                

tca ttt aaa gat gtg act gtg ggc ttc acc cag gag gag tgg cag cac      700
Ser Phe Lys Asp Val Thr Val Gly Phe Thr Gln Glu Glu Trp Gln His         
        15                  20                  25                      

ctg gac cct agt cag agg gct ctg tat aga gat gtg atg ctg gag aac      748
Leu Asp Pro Ser Gln Arg Ala Leu Tyr Arg Asp Val Met Leu Glu Asn         
    30                  35                  40                          

tac agc aac ctt gtc tca gtg ggg tat tgt gtt cac aaa cca gag gtg      796
Tyr Ser Asn Leu Val Ser Val Gly Tyr Cys Val His Lys Pro Glu Val         
45                  50                  55                  60          

atc ttc agg ctg caa caa gga gaa gag cca tgg aaa cag gag gaa gaa      844
Ile Phe Arg Leu Gln Gln Gly Glu Glu Pro Trp Lys Gln Glu Glu Glu         
                65                  70                  75              

ttc cca agc caa agc ttt cca gaa gtc tgg aca gct gat cac ctg aaa      892
Phe Pro Ser Gln Ser Phe Pro Glu Val Trp Thr Ala Asp His Leu Lys         
            80                  85                  90                  

gag agg agc caa gaa aac caa tct aaa cat ttg tgg gaa gtt gta ttc      940
Glu Arg Ser Gln Glu Asn Gln Ser Lys His Leu Trp Glu Val Val Phe         
        95                  100                 105                     

atc aat aat gaa atg ctg act aag gaa caa ggt gat gta ata gga ata      988
Ile Asn Asn Glu Met Leu Thr Lys Glu Gln Gly Asp Val Ile Gly Ile         
    110                 115                 120                         

cca ttt aat gtg gat gta agt tct ttt cct tcc aga aaa atg ttc tgt     1036
Pro Phe Asn Val Asp Val Ser Ser Phe Pro Ser Arg Lys Met Phe Cys         
125                 130                 135                 140         

cag tgt gat tca tgt gga atg agt ttc aac act gtt tca gaa ttg gtt     1084
Gln Cys Asp Ser Cys Gly Met Ser Phe Asn Thr Val Ser Glu Leu Val         
                145                 150                 155             

atc agt aag ata aac tat tta gga aaa aag tct gat gaa ttt aat gcc     1132
Ile Ser Lys Ile Asn Tyr Leu Gly Lys Lys Ser Asp Glu Phe Asn Ala         
            160                 165                 170                 

tgt ggg aaa ttg tta ctc aat att aag cat gat gaa act cat act caa     1180
Cys Gly Lys Leu Leu Leu Asn Ile Lys His Asp Glu Thr His Thr Gln         
        175                 180                 185                     

gag aaa aat gaa gtt ttg aaa aat agg aac aca ctg agt cat cat gag     1228
Glu Lys Asn Glu Val Leu Lys Asn Arg Asn Thr Leu Ser His His Glu         
    190                 195                 200                         

gag act ttg cag cat gag aag att caa act tta gag cac aat ttt gaa     1276
Glu Thr Leu Gln His Glu Lys Ile Gln Thr Leu Glu His Asn Phe Glu         
205                 210                 215                 220         

tac agt ata tgt cag gaa acc ctc ctt gaa aag gca gta ttc aat aca     1324
Tyr Ser Ile Cys Gln Glu Thr Leu Leu Glu Lys Ala Val Phe Asn Thr         
                225                 230                 235             

cag aag aga gag aac gca gaa gag aat aac tgt gat tat aat gaa ttt     1372
Gln Lys Arg Glu Asn Ala Glu Glu Asn Asn Cys Asp Tyr Asn Glu Phe         
            240                 245                 250                 

ggg aga act ttg tgt gat agt tca tcc ctc ttg ttc cat cag ata tct     1420
Gly Arg Thr Leu Cys Asp Ser Ser Ser Leu Leu Phe His Gln Ile Ser         
        255                 260                 265                     

ccg tca agg gac aat cac tat gaa ttt agt gat tgt gag aag ttc tta     1468
Pro Ser Arg Asp Asn His Tyr Glu Phe Ser Asp Cys Glu Lys Phe Leu         
    270                 275                 280                         

tgt gtg aag tcc acc ctt tct aaa cct cat ggg gta tct atg aaa cac     1516
Cys Val Lys Ser Thr Leu Ser Lys Pro His Gly Val Ser Met Lys His         
285                 290                 295                 300         

tat gat tgt ggt gaa agt ggg aat aat ttc agg agg aaa ttg tgt ctg     1564
Tyr Asp Cys Gly Glu Ser Gly Asn Asn Phe Arg Arg Lys Leu Cys Leu         
                305                 310                 315             

tca cac ctt cag aaa ggt gat aaa gga gag aaa cac ttt gaa tgt aat     1612
Ser His Leu Gln Lys Gly Asp Lys Gly Glu Lys His Phe Glu Cys Asn         
            320                 325                 330                 

gaa tgt ggg aaa gct ttc tgg gag aag tca cat ctc act cga cat cag     1660
Glu Cys Gly Lys Ala Phe Trp Glu Lys Ser His Leu Thr Arg His Gln         
        335                 340                 345                     

agg gtg cac aca gga cag aaa ccc ttt caa tgt aat gaa tgt gaa aaa     1708
Arg Val His Thr Gly Gln Lys Pro Phe Gln Cys Asn Glu Cys Glu Lys         
    350                 355                 360                         

gct ttc tgg gat aag tca aac ctc act aaa cat caa aga tca cac aca     1756
Ala Phe Trp Asp Lys Ser Asn Leu Thr Lys His Gln Arg Ser His Thr         
365                 370                 375                 380         

ggg gag aaa cct ttt gaa tgc aat gaa tgt ggg aaa gcc ttt agc cat     1804
Gly Glu Lys Pro Phe Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser His         
                385                 390                 395             

aag tca gcc ctc aca tta cac cag aga aca cat aca ggg gag aaa ccc     1852
Lys Ser Ala Leu Thr Leu His Gln Arg Thr His Thr Gly Glu Lys Pro         
            400                 405                 410                 

tat caa tgt aat gcg tgt ggg aaa act ttt tgc cag aaa tct gac ctc     1900
Tyr Gln Cys Asn Ala Cys Gly Lys Thr Phe Cys Gln Lys Ser Asp Leu         
        415                 420                 425                     

act aaa cat cag aga aca cac aca ggg ctg aaa ccc tat gaa tgt tat     1948
Thr Lys His Gln Arg Thr His Thr Gly Leu Lys Pro Tyr Glu Cys Tyr         
    430                 435                 440                         

gaa tgt gga aaa tcc ttc cgt gtg act tcg cac ctt aaa gta cac cag     1996
Glu Cys Gly Lys Ser Phe Arg Val Thr Ser His Leu Lys Val His Gln         
445                 450                 455                 460         

aga act cac aca ggt gag aaa cct ttt gaa tgt ctt gag tgt ggg aaa     2044
Arg Thr His Thr Gly Glu Lys Pro Phe Glu Cys Leu Glu Cys Gly Lys         
                465                 470                 475             

tcc ttt agt gaa aag tca aat ctt aca cag cat cag aga att cac ata     2092
Ser Phe Ser Glu Lys Ser Asn Leu Thr Gln His Gln Arg Ile His Ile         
            480                 485                 490                 

gga gat aaa tct tat gaa tgt aat gca tgt ggg aaa act ttc tac cac     2140
Gly Asp Lys Ser Tyr Glu Cys Asn Ala Cys Gly Lys Thr Phe Tyr His         
        495                 500                 505                     

aag tca tta ctc acc agg cat cag ata att cat aca ggg tgg aaa cct     2188
Lys Ser Leu Leu Thr Arg His Gln Ile Ile His Thr Gly Trp Lys Pro         
    510                 515                 520                         

tat gaa tgt tat gaa tgt ggg aaa acc ttc tgc ttg aag tca gac ctc     2236
Tyr Glu Cys Tyr Glu Cys Gly Lys Thr Phe Cys Leu Lys Ser Asp Leu         
525                 530                 535                 540         

aca gta cat cag aga aca cac aca ggg cag aaa ccc ttt gca tgt ccc     2284
Thr Val His Gln Arg Thr His Thr Gly Gln Lys Pro Phe Ala Cys Pro         
                545                 550                 555             

gaa tgt ggg aaa ttc ttt agc cat aag tca acc ctc tct caa cat tat     2332
Glu Cys Gly Lys Phe Phe Ser His Lys Ser Thr Leu Ser Gln His Tyr         
            560                 565                 570                 

aga aca cac aca ggg gag aaa ccc tac gaa tgt cat gaa tgt gga aaa     2380
Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys His Glu Cys Gly Lys         
        575                 580                 585                     

atc ttt tac aat aaa tca tac cta act aaa cat aat aga aca cat aca     2428
Ile Phe Tyr Asn Lys Ser Tyr Leu Thr Lys His Asn Arg Thr His Thr         
    590                 595                 600                         

ggg gag aaa ccc tat gaa tgt aat gaa tgt gga aaa gcc ttc tac cag     2476
Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Tyr Gln         
605                 610                 615                 620         

aag tca caa ctc act cag cat cag aga att cac ata ggg gag aaa ccc     2524
Lys Ser Gln Leu Thr Gln His Gln Arg Ile His Ile Gly Glu Lys Pro         
                625                 630                 635             

tat aaa tgt aat gag tgt gga aaa gct ttc tgc cat aag tca gct cta     2572
Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Cys His Lys Ser Ala Leu         
            640                 645                 650                 

att gta cat cag aga acc cat aca caa gaa aag ccc tat aaa tgt aat     2620
Ile Val His Gln Arg Thr His Thr Gln Glu Lys Pro Tyr Lys Cys Asn         
        655                 660                 665                     

gaa tgt gga aaa tct ttc tgt gta aaa tca gga ctt att ttc cat gag     2668
Glu Cys Gly Lys Ser Phe Cys Val Lys Ser Gly Leu Ile Phe His Glu         
    670                 675                 680                         

aga aag cac acg ggg gag aaa ccc tat gaa tgc aat gaa tgt ggg aaa     2716
Arg Lys His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys         
685                 690                 695                 700         

ttc ttc agg cac aaa tca tca ctc aca gta cat cac agg gct cac aca     2764
Phe Phe Arg His Lys Ser Ser Leu Thr Val His His Arg Ala His Thr         
                705                 710                 715             

gga gag aaa tct tgt caa tgt aat gaa tgt gga aaa atc ttt tac cgt     2812
Gly Glu Lys Ser Cys Gln Cys Asn Glu Cys Gly Lys Ile Phe Tyr Arg         
            720                 725                 730                 

aaa tcg gaa ctt gct caa cat cag aga tca cat aca ggg gaa aag ccc     2860
Lys Ser Glu Leu Ala Gln His Gln Arg Ser His Thr Gly Glu Lys Pro         
        735                 740                 745                     

tat gaa tgt aac aca tgc agg aaa act ttc tct caa aag tca aat ctc     2908
Tyr Glu Cys Asn Thr Cys Arg Lys Thr Phe Ser Gln Lys Ser Asn Leu         
    750                 755                 760                         

att gta cat cag aga aga cat ata gga gaa aac ctt atg aat gaa atg     2956
Ile Val His Gln Arg Arg His Ile Gly Glu Asn Leu Met Asn Glu Met         
765                 770                 775                 780         

gat att aga aat ttc cag cca caa gtc agc ctc cat aat gcc tca gag     3004
Asp Ile Arg Asn Phe Gln Pro Gln Val Ser Leu His Asn Ala Ser Glu         
                785                 790                 795             

tat tca cac tgt gga gaa agc cct gat gac atc ctg aat gtt cag taa     3052
Tyr Ser His Cys Gly Glu Ser Pro Asp Asp Ile Leu Asn Val Gln             
            800                 805                 810                 

ctatccacaa actcacctta tgttactcca aagtaatagt aggggataaa cccatagact   3112

acaacaatta taggacagct tttgttagga agtgatattc tatgtaatat cagatggtta   3172

atacgggcat aacaccttac agattttttt tgaatttgtg aaagtttttg gcaaaaatgc   3232

aaataaggtt atgttagaat ttacactgag gagaaaattg tcaatttaag aaatctaaag   3292

tgaaaatttt gcttagaaat aaaatacgac aagttatgtt ttgagtttga tgccataata   3352

gtttttaggg cacctaacaa taatttatag atgtatattg tggaatgtaa agctttaaga   3412

acttaaacaa aggtaataat taaaataacc tcacaagaag tttaatgagt agagagaatt   3472

cccatgtaca cttcaccaaa cttcctctaa ggataatgta taatcatagt atatggtcaa   3532

gtccaagaaa tcgatgttac cttgctggta gatagagact tagtcagatt ttactatggt   3592

ttgcatgcac tctgtgtgtg tgtgtacgtg tatgtgtgtg tgtgtggtta tatcaaactt   3652

ttacgacttt tacatttgag taaccatcaa cacgattagt ttacagaact gaaaaggaat   3712

ctgagatctg tactgtatca ggattacaaa ggatttagcc tcaagtagtt ccctttttgt   3772

attaataacc acacgctttc tgcaacccta tcccttgcat ccacttgact atgaagtttt   3832

tttaaagcac agataaattg aataatcagg gcaatagcat taagcacatc tgcgaattat   3892

ccctgaagtt caaaagactt atatatgtat aagtggtatg tgatataaat cgtgtgtttc   3952

atatgcataa tggaatttaa cgtaattgtg aataggaagt aggtatccta gtttagtagt   4012

ggttacatta tcaggcccat cccagatgtt tgtgatgtcc tgaaacaatt taaaaggaga   4072

cccacagagc taatgtttat ccatttaaaa ggtataaatc aaaataacaa attatctaaa   4132

aaaaatctat cctgtacatg tgaagatcta ggctcgcctc catgttactc cctttctctt   4192

cctacctgtg gctcatgcca tgccatgaag tgcctagggt acatatgtga acattccagc   4252

cttcagcata agtggtagtc caaattttct ttaagcagct gctctccaag acagggccct   4312

ggaaaggccc acacatacag cccagggctg cccagggctg ttggactgtc atttcaaggc   4372

tcattgtccc cagacaggga tctgggccct cagacttttg agaatatgaa gaggagggtt   4432

gaggctggag cagaaccaga atcaagctgg tgtggggctt ttattgatag tgtgaagatt   4492

gtacactata ttacatgatc agatcataca aataatctaa gattatacag tctagtgatc   4552

ctagattaca caagtaatct aagcttccac tttaggaaac tagaaaaaga agagcaaatt   4612

aaatccaaag taacctgaaa aaacattaga gtaaaaatca ttgaaattga aaagagaaaa   4672

tcgataaaac ccaaaactgg ttccttgaaa aggtcagtaa aattgataaa cctctagcta   4732

gcttaagaac aaacagaaga caaatattgc taataccaaa aatgaaagag gccatcacag   4792

ctaatcctat ggtcaccaaa aggattagaa agaaacatgg acaactctgt ccataaattt   4852

gataacttag ctaaaatgga ccaattcctt gcaagacgca ttctctcaaa gctcacacaa   4912

gatagacctc aataggcata tgtatctatt aaataaacca aagcagtaat taataacctt   4972

ccaaggccag gtacagtggt tcatgcctgt aatcccagca cttcactttg ggaggctgag   5032

gcgggtggat cacaaggtca ggagttcgag accagcctgg tcaacatggt gaaaccccct   5092

atctactaaa aatacaaaaa attagctggg catggtggca tgcgtgtgta gtcgaagcta   5152

ctcaggaggc tgaggcagaa gaatcacttg aacctgggag gtggatgttg cagtgagctg   5212

agattgtgcc actgtactgc agcctgggtg acagaatgag actgcatctc aaaaaataat   5272

aatgaaactt tccaaaacaa agtgccagga ccagctgggt tcactgatgt gtttttgaga   5332

tacttaaggt agaaatgata ccaagtctct accatctctt tcagaaaata aaagcagaga   5392

taacacttcc caactcattt tgtgaggcca gtattaccct aatagcaaaa ccaggcaaag   5452

atattacaag aaaggaaaac tacagatcaa tatttccatt gaacacagat gcagaaatcc   5512

tcaaaatatt agcaaatcag gaatgcaagg cttgttcaac atttgatatt cagtgtaatc   5572

cattgcatgc attagcagct caaagatgaa atacgatcat atcaataggt acagaaaaag   5632

catttgacaa aatccaatat ccattcatgt taaaacctct caacacagaa ggaatacagg   5692

agaacttact caagttggta aagaacatac tacaaaaaac cctacagcta acattatcct   5752

tgatgtttcc aactagacac tttcctacta agatcaggaa catggcaagg aacaccacac   5812

cactgctttt cagcattgta ctggaagtgc tatataatgc agtgttaaaa aaaaaagaaa   5872

taaaatgcac atagatttga aaggatgaaa tacaactttg ttcacaagta acatgattgt   5932

ctttgtagag aattctaaat aacaaaaacc ctgctgacat taataagcaa ttacagcagg   5992

attgcaggat acagtcctca ggtagatgat aaaaaggaat tggacatcaa gtcattaaaa   6052

gacacggaga aaccctaaat gcttattgtt aagtgaaaac caatctgaaa aggctttcta   6112

ttttgtatga ttgcaattat atgacatttt gggagaggca aaactattga gccagtgaaa   6172

ggaccagtgg ttgctgagag ttgaggggaa aggagggatg gcaggtagag aggtgatttt   6232

taaggcagtg aaagtactct ctagggtact gtaatttgtc aaaacgcaga gaatggaaaa   6292

cagtgaacgg aaaacacaga gtaaacccta atgtcaactc tggacttcag ttaataataa   6352

tgtatcactg ttggctcatt aattgtaaca aatgaaccat aatgatgcaa gatgttaatg   6412

attggggagc ctgtggaaga tgggagggga aagggttata tgagaattct ctatactttt   6472

tgctcaactt tctgtaaccc taaagctact ctaaaaaatg aagtgtatca agtaaataaa   6532

taaccaacca acc                                                      6545


<210>  26
<211>  811
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Phe Gln Val Glu Gln Lys Ser Gln Glu Ser Val Ser Phe Lys Asp 
1               5                   10                  15      


Val Thr Val Gly Phe Thr Gln Glu Glu Trp Gln His Leu Asp Pro Ser 
            20                  25                  30          


Gln Arg Ala Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser Asn Leu 
        35                  40                  45              


Val Ser Val Gly Tyr Cys Val His Lys Pro Glu Val Ile Phe Arg Leu 
    50                  55                  60                  


Gln Gln Gly Glu Glu Pro Trp Lys Gln Glu Glu Glu Phe Pro Ser Gln 
65                  70                  75                  80  


Ser Phe Pro Glu Val Trp Thr Ala Asp His Leu Lys Glu Arg Ser Gln 
                85                  90                  95      


Glu Asn Gln Ser Lys His Leu Trp Glu Val Val Phe Ile Asn Asn Glu 
            100                 105                 110         


Met Leu Thr Lys Glu Gln Gly Asp Val Ile Gly Ile Pro Phe Asn Val 
        115                 120                 125             


Asp Val Ser Ser Phe Pro Ser Arg Lys Met Phe Cys Gln Cys Asp Ser 
    130                 135                 140                 


Cys Gly Met Ser Phe Asn Thr Val Ser Glu Leu Val Ile Ser Lys Ile 
145                 150                 155                 160 


Asn Tyr Leu Gly Lys Lys Ser Asp Glu Phe Asn Ala Cys Gly Lys Leu 
                165                 170                 175     


Leu Leu Asn Ile Lys His Asp Glu Thr His Thr Gln Glu Lys Asn Glu 
            180                 185                 190         


Val Leu Lys Asn Arg Asn Thr Leu Ser His His Glu Glu Thr Leu Gln 
        195                 200                 205             


His Glu Lys Ile Gln Thr Leu Glu His Asn Phe Glu Tyr Ser Ile Cys 
    210                 215                 220                 


Gln Glu Thr Leu Leu Glu Lys Ala Val Phe Asn Thr Gln Lys Arg Glu 
225                 230                 235                 240 


Asn Ala Glu Glu Asn Asn Cys Asp Tyr Asn Glu Phe Gly Arg Thr Leu 
                245                 250                 255     


Cys Asp Ser Ser Ser Leu Leu Phe His Gln Ile Ser Pro Ser Arg Asp 
            260                 265                 270         


Asn His Tyr Glu Phe Ser Asp Cys Glu Lys Phe Leu Cys Val Lys Ser 
        275                 280                 285             


Thr Leu Ser Lys Pro His Gly Val Ser Met Lys His Tyr Asp Cys Gly 
    290                 295                 300                 


Glu Ser Gly Asn Asn Phe Arg Arg Lys Leu Cys Leu Ser His Leu Gln 
305                 310                 315                 320 


Lys Gly Asp Lys Gly Glu Lys His Phe Glu Cys Asn Glu Cys Gly Lys 
                325                 330                 335     


Ala Phe Trp Glu Lys Ser His Leu Thr Arg His Gln Arg Val His Thr 
            340                 345                 350         


Gly Gln Lys Pro Phe Gln Cys Asn Glu Cys Glu Lys Ala Phe Trp Asp 
        355                 360                 365             


Lys Ser Asn Leu Thr Lys His Gln Arg Ser His Thr Gly Glu Lys Pro 
    370                 375                 380                 


Phe Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser His Lys Ser Ala Leu 
385                 390                 395                 400 


Thr Leu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Gln Cys Asn 
                405                 410                 415     


Ala Cys Gly Lys Thr Phe Cys Gln Lys Ser Asp Leu Thr Lys His Gln 
            420                 425                 430         


Arg Thr His Thr Gly Leu Lys Pro Tyr Glu Cys Tyr Glu Cys Gly Lys 
        435                 440                 445             


Ser Phe Arg Val Thr Ser His Leu Lys Val His Gln Arg Thr His Thr 
    450                 455                 460                 


Gly Glu Lys Pro Phe Glu Cys Leu Glu Cys Gly Lys Ser Phe Ser Glu 
465                 470                 475                 480 


Lys Ser Asn Leu Thr Gln His Gln Arg Ile His Ile Gly Asp Lys Ser 
                485                 490                 495     


Tyr Glu Cys Asn Ala Cys Gly Lys Thr Phe Tyr His Lys Ser Leu Leu 
            500                 505                 510         


Thr Arg His Gln Ile Ile His Thr Gly Trp Lys Pro Tyr Glu Cys Tyr 
        515                 520                 525             


Glu Cys Gly Lys Thr Phe Cys Leu Lys Ser Asp Leu Thr Val His Gln 
    530                 535                 540                 


Arg Thr His Thr Gly Gln Lys Pro Phe Ala Cys Pro Glu Cys Gly Lys 
545                 550                 555                 560 


Phe Phe Ser His Lys Ser Thr Leu Ser Gln His Tyr Arg Thr His Thr 
                565                 570                 575     


Gly Glu Lys Pro Tyr Glu Cys His Glu Cys Gly Lys Ile Phe Tyr Asn 
            580                 585                 590         


Lys Ser Tyr Leu Thr Lys His Asn Arg Thr His Thr Gly Glu Lys Pro 
        595                 600                 605             


Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Tyr Gln Lys Ser Gln Leu 
    610                 615                 620                 


Thr Gln His Gln Arg Ile His Ile Gly Glu Lys Pro Tyr Lys Cys Asn 
625                 630                 635                 640 


Glu Cys Gly Lys Ala Phe Cys His Lys Ser Ala Leu Ile Val His Gln 
                645                 650                 655     


Arg Thr His Thr Gln Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys 
            660                 665                 670         


Ser Phe Cys Val Lys Ser Gly Leu Ile Phe His Glu Arg Lys His Thr 
        675                 680                 685             


Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Phe Phe Arg His 
    690                 695                 700                 


Lys Ser Ser Leu Thr Val His His Arg Ala His Thr Gly Glu Lys Ser 
705                 710                 715                 720 


Cys Gln Cys Asn Glu Cys Gly Lys Ile Phe Tyr Arg Lys Ser Glu Leu 
                725                 730                 735     


Ala Gln His Gln Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Asn 
            740                 745                 750         


Thr Cys Arg Lys Thr Phe Ser Gln Lys Ser Asn Leu Ile Val His Gln 
        755                 760                 765             


Arg Arg His Ile Gly Glu Asn Leu Met Asn Glu Met Asp Ile Arg Asn 
    770                 775                 780                 


Phe Gln Pro Gln Val Ser Leu His Asn Ala Ser Glu Tyr Ser His Cys 
785                 790                 795                 800 


Gly Glu Ser Pro Asp Asp Ile Leu Asn Val Gln 
                805                 810     


<210>  27
<211>  1996
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (20)..(619)
<223>  

<400>  27
acccatcctt ctttctttt atg ccc gca gag aga gta gtt aag cct tca gag      52
                     Met Pro Ala Glu Arg Val Val Lys Pro Ser Glu        
                     1               5                   10             

cag ttc cag gag tcc att tac ggg agg ggg gag atg agc gct gct gag      100
Gln Phe Gln Glu Ser Ile Tyr Gly Arg Gly Glu Met Ser Ala Ala Glu         
            15                  20                  25                  

gct tgg ggg ctc agg tcc cgc acc att ccc cct ccg cga caa tct gag      148
Ala Trp Gly Leu Arg Ser Arg Thr Ile Pro Pro Pro Arg Gln Ser Glu         
        30                  35                  40                      

aga gct cca gtg gtt act ttt atc tac ctg tcc gtt cac cct aaa ctg      196
Arg Ala Pro Val Val Thr Phe Ile Tyr Leu Ser Val His Pro Lys Leu         
    45                  50                  55                          

tca ctc gtc agt ctc act ctg aga aga gac agt aac ttg aaa cgt tgt      244
Ser Leu Val Ser Leu Thr Leu Arg Arg Asp Ser Asn Leu Lys Arg Cys         
60                  65                  70                  75          

tct aaa ctc cta ggc ccg tcc ccc aaa cac cct ttt gac tgg gac ccc      292
Ser Lys Leu Leu Gly Pro Ser Pro Lys His Pro Phe Asp Trp Asp Pro         
                80                  85                  90              

cgc ccc tgc atg gga cct cgc gca gag ggg ggt gtg tat gtg tgt gag      340
Arg Pro Cys Met Gly Pro Arg Ala Glu Gly Gly Val Tyr Val Cys Glu         
            95                  100                 105                 

tgt aga gga agg ctt ggc cta agg cct ctc ctt ctc cct ccc ctt gcc      388
Cys Arg Gly Arg Leu Gly Leu Arg Pro Leu Leu Leu Pro Pro Leu Ala         
        110                 115                 120                     

tct ggg gtg ggg gtg ggg tgt tgt ggc tgt gtg tgt ggc tgt ggc tcc      436
Ser Gly Val Gly Val Gly Cys Cys Gly Cys Val Cys Gly Cys Gly Ser         
    125                 130                 135                         

gtc ccg ggg gtt ctg tca ccc ggc tgt gtc cag cct cct ctc cac ccc      484
Val Pro Gly Val Leu Ser Pro Gly Cys Val Gln Pro Pro Leu His Pro         
140                 145                 150                 155         

cca tac cta aga gtc acc aac ccg ggg tgt gat tca cca ccc gct gga      532
Pro Tyr Leu Arg Val Thr Asn Pro Gly Cys Asp Ser Pro Pro Ala Gly         
                160                 165                 170             

acc gtg caa cct ttc ccc gag gaa gaa gga gga ggt aga agc cag ttg      580
Thr Val Gln Pro Phe Pro Glu Glu Glu Gly Gly Gly Arg Ser Gln Leu         
            175                 180                 185                 

agc aga aat cct ctc att aac cac tgc gtc acg gtg tag tggaagggtg       629
Ser Arg Asn Pro Leu Ile Asn His Cys Val Thr Val                         
        190                 195                                         

ggtgttgtgg ctttttccct gtgacacaca catccacact cgctcaccct gtgctcactc    689

acggggtcgg tgtgtgttat gtgtgttggg tgtgtgtgtg tcggtgtctt tgtttgtgtg    749

tctacgcctg tgtgtgtatg tgtcaccccg taggagtgcg ccggtctcgg ggaaatgccc    809

ggttccttcg tgcccacggt caccgcgatc acaaccagcc aggacctcca gtggcttgtg    869

caacccaccc tcatctcttc catggcccag tcccaggggc agccactggc ctcccagccc    929

ccggtcgtcg acccctacga catgccggga accagctact ccacaccagg catgagtggc    989

tacagcagtg gcggagcgag tggcagtggt gggccttcca ccagcggaac taccagtggg   1049

cctgggcctg cccgcccagc ccgagcccgg cctaggagac cccgagagga gacgctcacc   1109

ccagaggaag aggagaagcg aagggtgcgc cgggaacgaa ataaactagc agcagctaaa   1169

tgcaggaacc ggcggaggga gctgaccgac cgactccagg cggtgaggac aggccctggg   1229

gtgggagagg ggatgctgag gggagctctc tccccattct ctgccccctc tccacctgta   1289

cccttatcct gggttgagaa ctagacgttc tacacatgga actaggtact gctgtggcca   1349

gactgggtag cccagggcac aaacacagac ccccatggac ttaagtcaac tcctggtccc   1409

cccccccatt tcctgacccc acggactact ctcctagcct tcatttcatc ccgaggggcc   1469

acatggggcc cttgaggaga ggggcgcccc catcatttct cccatctggt cttcagcaag   1529

taacaaccca ttttgcctca gtttctccat ctctgcaaac cctcatcaaa tctcccgggc   1589

tctttctacc cttaacactc tggaaagcct gtgaaatgaa attattccac ctcctgccct   1649

agccacccac agctctcctg gtgctggtgg catcccccaa aacccactcc cttcctacgt   1709

cctcccttgg tctgagagtt ccctgctgta tgcctgcagg gtgagctgtt actccttgag   1769

ggaacaaggg aattgtcaac tttccttctc tactttttct cttccccggg aggtagagag   1829

ggaggggtaa tagaagggaa cacattaaaa acacataaca gtggctcatg cctgtgatcc   1889

cagcactttg agaggccaag gcaggaggat tgcttgagcc caggagtttg agaccagcct   1949

gggaaacata gggaggactt gtctctacca aaaaaaaaaa aaaaaaa                 1996


<210>  28
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Pro Ala Glu Arg Val Val Lys Pro Ser Glu Gln Phe Gln Glu Ser 
1               5                   10                  15      


Ile Tyr Gly Arg Gly Glu Met Ser Ala Ala Glu Ala Trp Gly Leu Arg 
            20                  25                  30          


Ser Arg Thr Ile Pro Pro Pro Arg Gln Ser Glu Arg Ala Pro Val Val 
        35                  40                  45              


Thr Phe Ile Tyr Leu Ser Val His Pro Lys Leu Ser Leu Val Ser Leu 
    50                  55                  60                  


Thr Leu Arg Arg Asp Ser Asn Leu Lys Arg Cys Ser Lys Leu Leu Gly 
65                  70                  75                  80  


Pro Ser Pro Lys His Pro Phe Asp Trp Asp Pro Arg Pro Cys Met Gly 
                85                  90                  95      


Pro Arg Ala Glu Gly Gly Val Tyr Val Cys Glu Cys Arg Gly Arg Leu 
            100                 105                 110         


Gly Leu Arg Pro Leu Leu Leu Pro Pro Leu Ala Ser Gly Val Gly Val 
        115                 120                 125             


Gly Cys Cys Gly Cys Val Cys Gly Cys Gly Ser Val Pro Gly Val Leu 
    130                 135                 140                 


Ser Pro Gly Cys Val Gln Pro Pro Leu His Pro Pro Tyr Leu Arg Val 
145                 150                 155                 160 


Thr Asn Pro Gly Cys Asp Ser Pro Pro Ala Gly Thr Val Gln Pro Phe 
                165                 170                 175     


Pro Glu Glu Glu Gly Gly Gly Arg Ser Gln Leu Ser Arg Asn Pro Leu 
            180                 185                 190         


Ile Asn His Cys Val Thr Val 
        195                 


<210>  29
<211>  3632
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (594)..(1307)
<223>  

<400>  29
cattcataag actcagagct acggccacgg cagggacacg cggaaccaag acttggaaac     60

ttgattgttg tggttcttct tgggggttat gaaatttcat taatcttttt tttttccggg    120

gagaaagttt ttggaaagat tcttccagat atttcttcat tttcttttgg aggaccgact    180

tacttttttt ggtcttcttt attactcccc tccccccgtg ggacccgccg gacgcgtgga    240

ggagaccgta gctgaagctg attctgtaca gcgggacagc gctttctgcc cctgggggag    300

caacccctcc ctcgcccctg ggtcctacgg agcctgcact ttcaagaggt acagcggcat    360

cctgtggggg cctgggcacc gcaggaagac tgcacagaaa ctttgccatt gttggaacgg    420

gacgttgctc cttccccgag cttccccgga cagcgtactt tgaggactcg ctcagctcac    480

cggggactcc cacggctcac cccggacttg caccttactt ccccaacccg gccatagcct    540

tggcttcccg gcgacctcag cgtggtcaca ggggcccccc tgtgcccagg gaa atg       596
                                                           Met          
                                                           1            

ttt cag gct ttc ccc gga gac tac gac tcc ggc tcc cgg tgc agc tcc      644
Phe Gln Ala Phe Pro Gly Asp Tyr Asp Ser Gly Ser Arg Cys Ser Ser         
            5                   10                  15                  

tca ccc tct gcc gag tct caa tat ctg tct tcg gtg gac tcc ttc ggc      692
Ser Pro Ser Ala Glu Ser Gln Tyr Leu Ser Ser Val Asp Ser Phe Gly         
        20                  25                  30                      

agt cca ccc acc gcc gcg gcc tcc cag gag tgc gcc ggt ctc ggg gaa      740
Ser Pro Pro Thr Ala Ala Ala Ser Gln Glu Cys Ala Gly Leu Gly Glu         
    35                  40                  45                          

atg ccc ggt tcc ttc gtg ccc acg gtc acc gcg atc aca acc agc cag      788
Met Pro Gly Ser Phe Val Pro Thr Val Thr Ala Ile Thr Thr Ser Gln         
50                  55                  60                  65          

gac ctc cag tgg ctt gtg caa ccc acc ctc atc tct tcc atg gcc cag      836
Asp Leu Gln Trp Leu Val Gln Pro Thr Leu Ile Ser Ser Met Ala Gln         
                70                  75                  80              

tcc cag ggg cag cca ctg gcc tcc cag ccc ccg gtc gtc gac ccc tac      884
Ser Gln Gly Gln Pro Leu Ala Ser Gln Pro Pro Val Val Asp Pro Tyr         
            85                  90                  95                  

gac atg ccg gga acc agc tac tcc aca cca ggc atg agt ggc tac agc      932
Asp Met Pro Gly Thr Ser Tyr Ser Thr Pro Gly Met Ser Gly Tyr Ser         
        100                 105                 110                     

agt ggc gga gcg agt ggc agt ggt ggg cct tcc acc agc gga act acc      980
Ser Gly Gly Ala Ser Gly Ser Gly Gly Pro Ser Thr Ser Gly Thr Thr         
    115                 120                 125                         

agt ggg cct ggg cct gcc cgc cca gcc cga gcc cgg cct agg aga ccc     1028
Ser Gly Pro Gly Pro Ala Arg Pro Ala Arg Ala Arg Pro Arg Arg Pro         
130                 135                 140                 145         

cga gag gag acg ctc acc cca gag gaa gag gag aag cga agg gtg cgc     1076
Arg Glu Glu Thr Leu Thr Pro Glu Glu Glu Glu Lys Arg Arg Val Arg         
                150                 155                 160             

cgg gaa cga aat aaa cta gca gca gct aaa tgc agg aac cgg cgg agg     1124
Arg Glu Arg Asn Lys Leu Ala Ala Ala Lys Cys Arg Asn Arg Arg Arg         
            165                 170                 175                 

gag ctg acc gac cga ctc cag gcg gag aca gat cag ttg gag gaa gaa     1172
Glu Leu Thr Asp Arg Leu Gln Ala Glu Thr Asp Gln Leu Glu Glu Glu         
        180                 185                 190                     

aaa gca gag ctg gag tcg gag atc gcc gag ctc caa aag gag aag gaa     1220
Lys Ala Glu Leu Glu Ser Glu Ile Ala Glu Leu Gln Lys Glu Lys Glu         
    195                 200                 205                         

cgt ctg gag ttt gtg ctg gtg gcc cac aaa ccg ggc tgc aag atc ccc     1268
Arg Leu Glu Phe Val Leu Val Ala His Lys Pro Gly Cys Lys Ile Pro         
210                 215                 220                 225         

tac gaa gag ggg ccc ggg ccg ggc ccg ctg gcg gag tga agttcaagtc      1317
Tyr Glu Glu Gly Pro Gly Pro Gly Pro Leu Ala Glu                         
                230                 235                                 

ctcggcgacc ccttccccgt tgttaaccct tcgtacactt cttcgtttgt cctcacctgc   1377

ccggaggtct ccgcgttcgc cggcgcccaa cgcaccagcg gcagtgacca gccttccgat   1437

cccctgaact cgccctccct cctcgctcgg tgaactcttt agacacacaa aacaaacaaa   1497

cacatggggg agagagactt ggaagaggag gaggaggagg agaaggagga gagagagggg   1557

aagagacaaa gtgggtgtgt ggcctccctg gctcctccgt ctgaccctct gcggccactg   1617

cgccactgcc atcggacagg aggattcctt gtgttttgtc ctgcctcttg tttctgtgcc   1677

ccggcgaggc cggagagctg gtgactttgg ggacaggggg tgggaagggg atggacaccc   1737

ccagctgact gttggctctc tgacgtcaac ccaagctctg gggatgggtg gggagggggg   1797

cgggtgacgc ccaccttcgg gagtcctgtg tgaggatgaa gggacggggg tgggaggtag   1857

gctgtggggt gggctggagt cctctccaga gaggctcaac aaggaaaaat gccactccct   1917

acccaatgtc tcccacaccc accctttttt tggggtgccc aggttggttt cccctgcact   1977

cccgacctta gcttattgat cccacatttc catggtgtga gatcctcttt actctgggca   2037

gaagtgagcc cccccttaaa gggaattcga tgccccccta gaataatctc atccccccac   2097

ccgacttctt ttgaaatgtg aacgtccttc cttgactgtc tagccactcc ctcccagaaa   2157

aactggctct gattggaatt tctggcctcc taaggctccc caccccgaaa tcagccccca   2217

gccttgtttc tgatgacagt gttatcccaa gaccctgccc cctgccagcc gaccctcctg   2277

gccttcctcg ttgggccgct ctgatttcag gcagcagggg ctgctgtgat gccgtcctgc   2337

tggagtgatt tatactgtga aatgagttgg ccagattgtg gggtgcagct gggtggggca   2397

gcacacctct ggggggataa tgtccccact cccgaaagcc tttcctcggt ctcccttccg   2457

tccatccccc ttcttcctcc cctcaacagt gagttagact caagggggtg acagaaccga   2517

gaagggggtg acagtcctcc atccacgtgg cctctctctc tctcctcagg accctcagcc   2577

ctggcctttt tctttaaggt cccccgacca atccccagcc taggacgcca acttctccca   2637

ccccttggcc cctcacatcc tctccaggaa ggcagtgagg ggctgtgaca tttttccgga   2697

gaagatttca gagctgaggc tttggtaccc ccaaaccccc aatatttgga ctggcagact   2757

caaggggctg gaatctcatg attccatgcc cgagtccgcc catccctgac catggttttg   2817

gctctcccac cccgccgttc cctgcgcttc atctcatgag gatttcttta tgaggcaaat   2877

ttatattttt taatatcggg gggtggacca cgccgccctc catccgtgct gcatgaaaaa   2937

cattccacgt gccccttgtc gcgcgtctcc catcctgatc ccagacccat tccttagcta   2997

tttatccctt tcctggtttc cgaaaggcaa ttatatctat tatgtataag taaatatatt   3057

atatatggat gtgtgtgtgt gcgtgcgcgt gagtgtgtga gcgcttctgc agcctcggcc   3117

taggtcacgt tggccctcaa agcgagccgt tgaattggaa actgcttcta gaaactctgg   3177

ctcagcctgt ctcgggctga cccttttctg atcgtctcgg cccctctgat tgttcccgat   3237

ggtctctctc cctctgtctt ttctcctccg cctgtgtcca tctgaccgtt ttcacttgtc   3297

tcctttctga ctgtccctgc caatgctcca gctgtcgtct gactctgggt tcgttgggga   3357

catgagattt tattttttgt gagtgagact gagggatcgt agatttttac aatctgtatc   3417

tttgacaatt ctgggtgcga gtgtgagagt gtgagcaggg cttgctcctg ccaaccacaa   3477

ttcaatgaat ccccgacccc cctaccccat gctgtacttg tggttctctt tttgtatttt   3537

gcatctgacc ccggggggct gggacagatt ggcaatgggc cgtcccctct ccccttggtt   3597

ctgcactgtt gccaataaaa agctcttaaa aacgc                              3632


<210>  30
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Phe Gln Ala Phe Pro Gly Asp Tyr Asp Ser Gly Ser Arg Cys Ser 
1               5                   10                  15      


Ser Ser Pro Ser Ala Glu Ser Gln Tyr Leu Ser Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Ser Pro Pro Thr Ala Ala Ala Ser Gln Glu Cys Ala Gly Leu Gly 
        35                  40                  45              


Glu Met Pro Gly Ser Phe Val Pro Thr Val Thr Ala Ile Thr Thr Ser 
    50                  55                  60                  


Gln Asp Leu Gln Trp Leu Val Gln Pro Thr Leu Ile Ser Ser Met Ala 
65                  70                  75                  80  


Gln Ser Gln Gly Gln Pro Leu Ala Ser Gln Pro Pro Val Val Asp Pro 
                85                  90                  95      


Tyr Asp Met Pro Gly Thr Ser Tyr Ser Thr Pro Gly Met Ser Gly Tyr 
            100                 105                 110         


Ser Ser Gly Gly Ala Ser Gly Ser Gly Gly Pro Ser Thr Ser Gly Thr 
        115                 120                 125             


Thr Ser Gly Pro Gly Pro Ala Arg Pro Ala Arg Ala Arg Pro Arg Arg 
    130                 135                 140                 


Pro Arg Glu Glu Thr Leu Thr Pro Glu Glu Glu Glu Lys Arg Arg Val 
145                 150                 155                 160 


Arg Arg Glu Arg Asn Lys Leu Ala Ala Ala Lys Cys Arg Asn Arg Arg 
                165                 170                 175     


Arg Glu Leu Thr Asp Arg Leu Gln Ala Glu Thr Asp Gln Leu Glu Glu 
            180                 185                 190         


Glu Lys Ala Glu Leu Glu Ser Glu Ile Ala Glu Leu Gln Lys Glu Lys 
        195                 200                 205             


Glu Arg Leu Glu Phe Val Leu Val Ala His Lys Pro Gly Cys Lys Ile 
    210                 215                 220                 


Pro Tyr Glu Glu Gly Pro Gly Pro Gly Pro Leu Ala Glu 
225                 230                 235         


<210>  31
<211>  2669
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (314)..(1828)
<223>  

<400>  31
ggccacgttc agcggacacg ggagcaagat ggcgattccg ggcaggcagt atgggcttat     60

tttgccaaag aaaacacagc agttgcaccc tgttttgcaa aaaccatcag tgtttgggaa    120

tgattctgat gatgatgatg agatggggtt tcactcttgt tgcccaggct ggagtgcaat    180

ggtgcaatct cggctcaccg caacctccac ctcctgggtt caagcgattt tcctgcctca    240

gcctcccaaa tagctgcaat tacagacctc tgtgagtgaa agccttcaga gggaagctgc    300

taagaagcag gcc atg aaa cag acc aaa ctg gaa atc cag aag gcc ctt       349
               Met Lys Gln Thr Lys Leu Glu Ile Gln Lys Ala Leu          
               1               5                   10                   

gca gaa gat gct act gtg tat gaa tat gac agt att tat gat gaa atg      397
Ala Glu Asp Ala Thr Val Tyr Glu Tyr Asp Ser Ile Tyr Asp Glu Met         
        15                  20                  25                      

cag aaa aaa aag gag gaa aat aat ccc aaa ttg ctt ttg ggg aaa gac      445
Gln Lys Lys Lys Glu Glu Asn Asn Pro Lys Leu Leu Leu Gly Lys Asp         
    30                  35                  40                          

aga aag ccc aag tat att cac aac ttg cta aaa gca gtt gag atc aga      493
Arg Lys Pro Lys Tyr Ile His Asn Leu Leu Lys Ala Val Glu Ile Arg         
45                  50                  55                  60          

aaa aag gaa cag gaa aaa aga atg gaa aag aaa ata cag aga gaa cga      541
Lys Lys Glu Gln Glu Lys Arg Met Glu Lys Lys Ile Gln Arg Glu Arg         
                65                  70                  75              

gaa atg gaa aag ggg gag ttt gat gat aaa gaa gca ttt gtg aca tct      589
Glu Met Glu Lys Gly Glu Phe Asp Asp Lys Glu Ala Phe Val Thr Ser         
            80                  85                  90                  

gca tat aag aaa aaa ctg caa gag aga gct gaa gaa gaa gaa aga gaa      637
Ala Tyr Lys Lys Lys Leu Gln Glu Arg Ala Glu Glu Glu Glu Arg Glu         
        95                  100                 105                     

aag agg gct gct gca ctg gaa gca tgt ttg gat gta acc aag cag aaa      685
Lys Arg Ala Ala Ala Leu Glu Ala Cys Leu Asp Val Thr Lys Gln Lys         
    110                 115                 120                         

gat ctc agt gga ttt tat agg cac cta tta aat caa gca gtt ggt gaa      733
Asp Leu Ser Gly Phe Tyr Arg His Leu Leu Asn Gln Ala Val Gly Glu         
125                 130                 135                 140         

aag gaa gta cct aaa tgc agc ttt cgt gaa gcc aga tct ggt ata aag      781
Lys Glu Val Pro Lys Cys Ser Phe Arg Glu Ala Arg Ser Gly Ile Lys         
                145                 150                 155             

gaa gaa aaa tca agg ggc ttc tcc aat gaa gta agt tca aaa aac aga      829
Glu Glu Lys Ser Arg Gly Phe Ser Asn Glu Val Ser Ser Lys Asn Arg         
            160                 165                 170                 

ata cca caa gag aaa tgc att ctt caa act gat gtg aaa gta gag gaa      877
Ile Pro Gln Glu Lys Cys Ile Leu Gln Thr Asp Val Lys Val Glu Glu         
        175                 180                 185                     

aac cca gat gca gac agt gac ttc gat gct aag agc agt gcg gat gat      925
Asn Pro Asp Ala Asp Ser Asp Phe Asp Ala Lys Ser Ser Ala Asp Asp         
    190                 195                 200                         

gaa ata gaa gaa act aga gtg aac tgc aga agg gaa aag gtc ata gag      973
Glu Ile Glu Glu Thr Arg Val Asn Cys Arg Arg Glu Lys Val Ile Glu         
205                 210                 215                 220         

acc cct gag aat gac ttc aag cac cac agg agt caa aac cac tct cgg     1021
Thr Pro Glu Asn Asp Phe Lys His His Arg Ser Gln Asn His Ser Arg         
                225                 230                 235             

tca cct agt gaa gaa aga ggg cac agt acc agg cac cac acg aaa gga     1069
Ser Pro Ser Glu Glu Arg Gly His Ser Thr Arg His His Thr Lys Gly         
            240                 245                 250                 

tca cga acg tcg aga gga cat gag aaa agg gaa gat cag cac cag cag     1117
Ser Arg Thr Ser Arg Gly His Glu Lys Arg Glu Asp Gln His Gln Gln         
        255                 260                 265                     

aag caa tcc aga gac caa gag aac cat tac act gac cgt gat tac cgg     1165
Lys Gln Ser Arg Asp Gln Glu Asn His Tyr Thr Asp Arg Asp Tyr Arg         
    270                 275                 280                         

aaa gaa agg gat tct cat agg cac aga gag gcc agt cat aga gat tcc     1213
Lys Glu Arg Asp Ser His Arg His Arg Glu Ala Ser His Arg Asp Ser         
285                 290                 295                 300         

cat tgg aag agg cat gaa cag gaa gat aaa cca agg gcg agg gac caa     1261
His Trp Lys Arg His Glu Gln Glu Asp Lys Pro Arg Ala Arg Asp Gln         
                305                 310                 315             

aga gaa aga agt gac aga gta tgg aaa agg gag aaa gat agg gag aaa     1309
Arg Glu Arg Ser Asp Arg Val Trp Lys Arg Glu Lys Asp Arg Glu Lys         
            320                 325                 330                 

tat tcc caa aga gaa caa gaa aga gat aga caa caa aat gat cag aac     1357
Tyr Ser Gln Arg Glu Gln Glu Arg Asp Arg Gln Gln Asn Asp Gln Asn         
        335                 340                 345                     

cga ccc agt gag aaa gga gag aag gaa gag aaa agc aaa gca aag gaa     1405
Arg Pro Ser Glu Lys Gly Glu Lys Glu Glu Lys Ser Lys Ala Lys Glu         
    350                 355                 360                         

gag cat atg aaa gta agg aag gaa aga tat gaa aat aat gat aaa tac     1453
Glu His Met Lys Val Arg Lys Glu Arg Tyr Glu Asn Asn Asp Lys Tyr         
365                 370                 375                 380         

aga gat aga gaa aaa cga gag gta ggt gtt cag tct tca gaa aga aat     1501
Arg Asp Arg Glu Lys Arg Glu Val Gly Val Gln Ser Ser Glu Arg Asn         
                385                 390                 395             

caa gac aga aag gaa agc agc cca aat tct agg gca aag gat aaa ttt     1549
Gln Asp Arg Lys Glu Ser Ser Pro Asn Ser Arg Ala Lys Asp Lys Phe         
            400                 405                 410                 

ctt gac caa gaa aga tcc aac aaa atg aga aac atg gca aag gac aaa     1597
Leu Asp Gln Glu Arg Ser Asn Lys Met Arg Asn Met Ala Lys Asp Lys         
        415                 420                 425                     

gaa aga aac caa gag aaa ccc tct aat tct gaa tca tca ctg gga gca     1645
Glu Arg Asn Gln Glu Lys Pro Ser Asn Ser Glu Ser Ser Leu Gly Ala         
    430                 435                 440                         

aaa cac aga ctc aca gag gaa ggg caa gag aag ggt aaa gaa caa gag     1693
Lys His Arg Leu Thr Glu Glu Gly Gln Glu Lys Gly Lys Glu Gln Glu         
445                 450                 455                 460         

aga cca cct gag gca gtg agc aag ttt gca aag cgg aac aat gaa gaa     1741
Arg Pro Pro Glu Ala Val Ser Lys Phe Ala Lys Arg Asn Asn Glu Glu         
                465                 470                 475             

act gta atg tca gct aga gac agg tac ttg gcc agg cag atg gcg cgg     1789
Thr Val Met Ser Ala Arg Asp Arg Tyr Leu Ala Arg Gln Met Ala Arg         
            480                 485                 490                 

gtt aat gca aag acc tat att gag aaa gaa gat gat tga tggctacccc      1838
Val Asn Ala Lys Thr Tyr Ile Glu Lys Glu Asp Asp                         
        495                 500                                         

aagagaaaga tttaaggaag cacagaaaac tgtaattcct ggaacctgct gcgtaaaacc   1898

ataaaggagt gtgttaccag tagtttggag ggcattttta aatttatttt caaaatttta   1958

agttaaaagt cagtcttaca gcttggatgt ttggatgtgg atgtttggct gaatttatat   2018

atagtgtgta ctcatcaata ccacattctt tgttgtattc aagaaccgtt aagagtgtgc   2078

taattccctg taggtacata atgaggaaaa tttgctccac tacaaccatt aaaaaataat   2138

tttggccaga tacggtagct cgtgcctgta ataccaacat tttgggaggc caaggcagaa   2198

ggatattgag gctaggcatt caagaccagc ctaggcagga taataagacc ttgtctctat   2258

ttaaaaaaca aaaagcctag catggtagtc catgcctgta gtcccagctg ttcgagaggc   2318

tgaggcaaga agatcacttg agcctaggaa tttgatgtta cagtgaggta tgatcatgcc   2378

actgcactcc aacctgggca acagaatgag accctgtctc taaaaaattt tttttaaata   2438

aataatttaa ctcttctaat aatgttttgt tgcaggaaat gtatttcaga taaaatatgg   2498

atttgaaaaa cagaaaatat actttatgtt ctgaaatttg tatttaagta taaaatgtga   2558

atcatcttgt ctaaatagct tacagcatag ttggcttaaa tgaaaataaa atgatatgct   2618

tatacatttg gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a            2669


<210>  32
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Lys Gln Thr Lys Leu Glu Ile Gln Lys Ala Leu Ala Glu Asp Ala 
1               5                   10                  15      


Thr Val Tyr Glu Tyr Asp Ser Ile Tyr Asp Glu Met Gln Lys Lys Lys 
            20                  25                  30          


Glu Glu Asn Asn Pro Lys Leu Leu Leu Gly Lys Asp Arg Lys Pro Lys 
        35                  40                  45              


Tyr Ile His Asn Leu Leu Lys Ala Val Glu Ile Arg Lys Lys Glu Gln 
    50                  55                  60                  


Glu Lys Arg Met Glu Lys Lys Ile Gln Arg Glu Arg Glu Met Glu Lys 
65                  70                  75                  80  


Gly Glu Phe Asp Asp Lys Glu Ala Phe Val Thr Ser Ala Tyr Lys Lys 
                85                  90                  95      


Lys Leu Gln Glu Arg Ala Glu Glu Glu Glu Arg Glu Lys Arg Ala Ala 
            100                 105                 110         


Ala Leu Glu Ala Cys Leu Asp Val Thr Lys Gln Lys Asp Leu Ser Gly 
        115                 120                 125             


Phe Tyr Arg His Leu Leu Asn Gln Ala Val Gly Glu Lys Glu Val Pro 
    130                 135                 140                 


Lys Cys Ser Phe Arg Glu Ala Arg Ser Gly Ile Lys Glu Glu Lys Ser 
145                 150                 155                 160 


Arg Gly Phe Ser Asn Glu Val Ser Ser Lys Asn Arg Ile Pro Gln Glu 
                165                 170                 175     


Lys Cys Ile Leu Gln Thr Asp Val Lys Val Glu Glu Asn Pro Asp Ala 
            180                 185                 190         


Asp Ser Asp Phe Asp Ala Lys Ser Ser Ala Asp Asp Glu Ile Glu Glu 
        195                 200                 205             


Thr Arg Val Asn Cys Arg Arg Glu Lys Val Ile Glu Thr Pro Glu Asn 
    210                 215                 220                 


Asp Phe Lys His His Arg Ser Gln Asn His Ser Arg Ser Pro Ser Glu 
225                 230                 235                 240 


Glu Arg Gly His Ser Thr Arg His His Thr Lys Gly Ser Arg Thr Ser 
                245                 250                 255     


Arg Gly His Glu Lys Arg Glu Asp Gln His Gln Gln Lys Gln Ser Arg 
            260                 265                 270         


Asp Gln Glu Asn His Tyr Thr Asp Arg Asp Tyr Arg Lys Glu Arg Asp 
        275                 280                 285             


Ser His Arg His Arg Glu Ala Ser His Arg Asp Ser His Trp Lys Arg 
    290                 295                 300                 


His Glu Gln Glu Asp Lys Pro Arg Ala Arg Asp Gln Arg Glu Arg Ser 
305                 310                 315                 320 


Asp Arg Val Trp Lys Arg Glu Lys Asp Arg Glu Lys Tyr Ser Gln Arg 
                325                 330                 335     


Glu Gln Glu Arg Asp Arg Gln Gln Asn Asp Gln Asn Arg Pro Ser Glu 
            340                 345                 350         


Lys Gly Glu Lys Glu Glu Lys Ser Lys Ala Lys Glu Glu His Met Lys 
        355                 360                 365             


Val Arg Lys Glu Arg Tyr Glu Asn Asn Asp Lys Tyr Arg Asp Arg Glu 
    370                 375                 380                 


Lys Arg Glu Val Gly Val Gln Ser Ser Glu Arg Asn Gln Asp Arg Lys 
385                 390                 395                 400 


Glu Ser Ser Pro Asn Ser Arg Ala Lys Asp Lys Phe Leu Asp Gln Glu 
                405                 410                 415     


Arg Ser Asn Lys Met Arg Asn Met Ala Lys Asp Lys Glu Arg Asn Gln 
            420                 425                 430         


Glu Lys Pro Ser Asn Ser Glu Ser Ser Leu Gly Ala Lys His Arg Leu 
        435                 440                 445             


Thr Glu Glu Gly Gln Glu Lys Gly Lys Glu Gln Glu Arg Pro Pro Glu 
    450                 455                 460                 


Ala Val Ser Lys Phe Ala Lys Arg Asn Asn Glu Glu Thr Val Met Ser 
465                 470                 475                 480 


Ala Arg Asp Arg Tyr Leu Ala Arg Gln Met Ala Arg Val Asn Ala Lys 
                485                 490                 495     


Thr Tyr Ile Glu Lys Glu Asp Asp 
            500                 


<210>  33
<211>  1230
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (103)..(678)
<223>  

<400>  33
ccacctccta cctgccgggc gggacgagca acatgattgg tggaatcgag taattactga     60

tcagtattgt ccaatcacgg agggcagttt agagccggcc ca atg agg gcc tcc       114
                                               Met Arg Ala Ser          
                                               1                        

agg ggc ggg tcg gac tgc cgc ggg ccg ggg agc gct ctg ggt ggc cag      162
Arg Gly Gly Ser Asp Cys Arg Gly Pro Gly Ser Ala Leu Gly Gly Gln         
5                   10                  15                  20          

ctg tgg gcc cgg gcc gtc gtg ggc tcc ggc ttg cgt gcg gag atg agc      210
Leu Trp Ala Arg Ala Val Val Gly Ser Gly Leu Arg Ala Glu Met Ser         
                25                  30                  35              

ggg tcc ctc ggc cga gct gcg gcg gct ctg ctc cgc tgg ggg cgc ggc      258
Gly Ser Leu Gly Arg Ala Ala Ala Ala Leu Leu Arg Trp Gly Arg Gly         
            40                  45                  50                  

gcg ggc ggc ggt ggc ctt tgg ggt ccg ggc gtg cgg gcg gcg ggc tcg      306
Ala Gly Gly Gly Gly Leu Trp Gly Pro Gly Val Arg Ala Ala Gly Ser         
        55                  60                  65                      

ggc gcg ggc ggc ggc ggc tcg gcg gag cag ttg gac gcg ctg gtg aag      354
Gly Ala Gly Gly Gly Gly Ser Ala Glu Gln Leu Asp Ala Leu Val Lys         
    70                  75                  80                          

aag gac aag gtg gtg gtc ttc ctc aag ggg acg ccg gag cag ccc cag      402
Lys Asp Lys Val Val Val Phe Leu Lys Gly Thr Pro Glu Gln Pro Gln         
85                  90                  95                  100         

tgc ggc ttc agc aac gcc gtg gtg cag atc ctg cgg ctg cac ggc gtc      450
Cys Gly Phe Ser Asn Ala Val Val Gln Ile Leu Arg Leu His Gly Val         
                105                 110                 115             

cgc gat tac gcg gcc tac aac gtg ctg gac gac ccg gag ctc cga caa      498
Arg Asp Tyr Ala Ala Tyr Asn Val Leu Asp Asp Pro Glu Leu Arg Gln         
            120                 125                 130                 

ggc att aaa gac tat tcc aac tgg ccc acc atc ccg caa gtg tac ctc      546
Gly Ile Lys Asp Tyr Ser Asn Trp Pro Thr Ile Pro Gln Val Tyr Leu         
        135                 140                 145                     

aat ggc gag ttt gta ggg ggc tgt gac att ctt ctg cag atg cac cag      594
Asn Gly Glu Phe Val Gly Gly Cys Asp Ile Leu Leu Gln Met His Gln         
    150                 155                 160                         

aat ggg gac ttg gtg gaa gaa ctg aaa aag ctg ggg atc cac tcc gcc      642
Asn Gly Asp Leu Val Glu Glu Leu Lys Lys Leu Gly Ile His Ser Ala         
165                 170                 175                 180         

ctt tta gat gaa aag aaa gac caa gac tcc aag tga gggcggccaa           688
Leu Leu Asp Glu Lys Lys Asp Gln Asp Ser Lys                             
                185                 190                                 

gtcctcgctg agcagagagg gagccgttca tgtcagagac tcactgccag aaaagcctta    748

cccattttgg ttttcactat tgagaccgca actgcttgca ctgatcattt tggttcatga    808

gcagttggtg attttagttg gtctggtgtt cgggctaaga atattttatt gtggacttaa    868

ttacaaccac tgcactgtaa tgattcaatg ctgtattatg atattgctgt aaacaaaatt    928

cattcttata ttgtcactta ttctttgcct gattcagaag ttaaatagga gctttggaat    988

cattattcat gacccctctg caaatgtgtc agtctccaaa gagagtatct ccccccaaat   1048

tttgtgtagc ttcttttgtt atggaaaatg gtggacaaaa aaagaaactg tgataactgg   1108

ggcgttgttt tttaaaataa actccagcac agggatgctg tgcatgcctg agttgattcc   1168

gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1228

aa                                                                  1230


<210>  34
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Arg Ala Ser Arg Gly Gly Ser Asp Cys Arg Gly Pro Gly Ser Ala 
1               5                   10                  15      


Leu Gly Gly Gln Leu Trp Ala Arg Ala Val Val Gly Ser Gly Leu Arg 
            20                  25                  30          


Ala Glu Met Ser Gly Ser Leu Gly Arg Ala Ala Ala Ala Leu Leu Arg 
        35                  40                  45              


Trp Gly Arg Gly Ala Gly Gly Gly Gly Leu Trp Gly Pro Gly Val Arg 
    50                  55                  60                  


Ala Ala Gly Ser Gly Ala Gly Gly Gly Gly Ser Ala Glu Gln Leu Asp 
65                  70                  75                  80  


Ala Leu Val Lys Lys Asp Lys Val Val Val Phe Leu Lys Gly Thr Pro 
                85                  90                  95      


Glu Gln Pro Gln Cys Gly Phe Ser Asn Ala Val Val Gln Ile Leu Arg 
            100                 105                 110         


Leu His Gly Val Arg Asp Tyr Ala Ala Tyr Asn Val Leu Asp Asp Pro 
        115                 120                 125             


Glu Leu Arg Gln Gly Ile Lys Asp Tyr Ser Asn Trp Pro Thr Ile Pro 
    130                 135                 140                 


Gln Val Tyr Leu Asn Gly Glu Phe Val Gly Gly Cys Asp Ile Leu Leu 
145                 150                 155                 160 


Gln Met His Gln Asn Gly Asp Leu Val Glu Glu Leu Lys Lys Leu Gly 
                165                 170                 175     


Ile His Ser Ala Leu Leu Asp Glu Lys Lys Asp Gln Asp Ser Lys 
            180                 185                 190     


<210>  35
<211>  2492
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (306)..(1409)
<223>  

<400>  35
agcactcccg ccctagcaac gtgcgcctgc tgctaggggc ggaggcgcgg gagggctcgg     60

aggctgttcc cacccccagg ctccgcgttc ccgccggccc cagctccagc cccgcagccc    120

accgtgcaaa catgcttaga cagagaagag attaacttca gtggcttccc actaattaca    180

gagattaaga agtggctgcc tgaactattt tccaaaggat acacattaca aattattgaa    240

tagggcagct aaccaagaag atcctattgg tttgggggga acacaacttc cagcagccac    300

aaggg atg ctg cta ctc agg tgc caa ctg aaa caa gct cct cca cag aag    350
      Met Leu Leu Leu Arg Cys Gln Leu Lys Gln Ala Pro Pro Gln Lys       
      1               5                   10                  15        

gtt tcg ttt agg ttt tgt gtc gtg atg ggg aaa cag caa agc aaa ctc      398
Val Ser Phe Arg Phe Cys Val Val Met Gly Lys Gln Gln Ser Lys Leu         
                20                  25                  30              

aaa cac agc act tat aaa tac ggc agg cct gat gaa att ata gaa gag      446
Lys His Ser Thr Tyr Lys Tyr Gly Arg Pro Asp Glu Ile Ile Glu Glu         
            35                  40                  45                  

aga att caa act aaa gct ttt caa gag tat agc cca gct cac atg gat      494
Arg Ile Gln Thr Lys Ala Phe Gln Glu Tyr Ser Pro Ala His Met Asp         
        50                  55                  60                      

acc gtc tct gtc gtg gct gct ttg aac tca gac ctt tgt gtc tct gga      542
Thr Val Ser Val Val Ala Ala Leu Asn Ser Asp Leu Cys Val Ser Gly         
    65                  70                  75                          

ggg aaa gat aag aca gtt gtg gcc tat aat tgg aaa act gga aat gtg      590
Gly Lys Asp Lys Thr Val Val Ala Tyr Asn Trp Lys Thr Gly Asn Val         
80                  85                  90                  95          

gtg aaa agg ttc aaa gga cat gaa cat gag atc acc aag gta gcc tgt      638
Val Lys Arg Phe Lys Gly His Glu His Glu Ile Thr Lys Val Ala Cys         
                100                 105                 110             

att ccc aaa tcc agc cag ttc ttc agt gcc tct cgt gac agg atg gtc      686
Ile Pro Lys Ser Ser Gln Phe Phe Ser Ala Ser Arg Asp Arg Met Val         
            115                 120                 125                 

atg atg tgg gac ttg cac ggt tcc tca caa cca agg cag caa ttg tgt      734
Met Met Trp Asp Leu His Gly Ser Ser Gln Pro Arg Gln Gln Leu Cys         
        130                 135                 140                     

ggc cat gcc atg gtg gtc acc gga ttg gct gtg agt cca gac tca tca      782
Gly His Ala Met Val Val Thr Gly Leu Ala Val Ser Pro Asp Ser Ser         
    145                 150                 155                         

cag ctg tgc act ggc tct cgg gac aac acc ctg ctt ctg tgg gat gtg      830
Gln Leu Cys Thr Gly Ser Arg Asp Asn Thr Leu Leu Leu Trp Asp Val         
160                 165                 170                 175         

gtg aca gga cag agt gtg gaa aga gca tct gtc tcc agg aac gtg gtc      878
Val Thr Gly Gln Ser Val Glu Arg Ala Ser Val Ser Arg Asn Val Val         
                180                 185                 190             

act cac ctg tgc tgg gtc ccc aga gaa cca tac ata cta cag acc tct      926
Thr His Leu Cys Trp Val Pro Arg Glu Pro Tyr Ile Leu Gln Thr Ser         
            195                 200                 205                 

gaa gat aaa acc ctc aga tta tgg gac agt cgg ggg ctg cag gta gct      974
Glu Asp Lys Thr Leu Arg Leu Trp Asp Ser Arg Gly Leu Gln Val Ala         
        210                 215                 220                     

cat atg ttt cct gca aag cag cac att cag acc tac tgt gaa gtc agt     1022
His Met Phe Pro Ala Lys Gln His Ile Gln Thr Tyr Cys Glu Val Ser         
    225                 230                 235                         

gtg gat gga cac aag tgt atc tcc tgc agc aat ggc ttt gga gga gaa     1070
Val Asp Gly His Lys Cys Ile Ser Cys Ser Asn Gly Phe Gly Gly Glu         
240                 245                 250                 255         

ggc tgt gaa gcc acg ttg tgg gac cta aga cag act cga aac aga ata     1118
Gly Cys Glu Ala Thr Leu Trp Asp Leu Arg Gln Thr Arg Asn Arg Ile         
                260                 265                 270             

tgt gag tat aag ggg cat ttc cag act gtc gca tcc tgc gtc ttt cta     1166
Cys Glu Tyr Lys Gly His Phe Gln Thr Val Ala Ser Cys Val Phe Leu         
            275                 280                 285                 

cca aga gca ttg gcc ttg atg cct tta att gct acc tca tca cat gat     1214
Pro Arg Ala Leu Ala Leu Met Pro Leu Ile Ala Thr Ser Ser His Asp         
        290                 295                 300                     

tgc aag gtg aag att tgg aac caa gat act gga gcc tgc ctt ttc acc     1262
Cys Lys Val Lys Ile Trp Asn Gln Asp Thr Gly Ala Cys Leu Phe Thr         
    305                 310                 315                         

ttg tct ctg gat gga tca gga ccc ttg act tct ctg gct gtt ggt gac     1310
Leu Ser Leu Asp Gly Ser Gly Pro Leu Thr Ser Leu Ala Val Gly Asp         
320                 325                 330                 335         

gcc atc tcc tta ttg tgt gca agt ttt aac aga gga att cac tta ctc     1358
Ala Ile Ser Leu Leu Cys Ala Ser Phe Asn Arg Gly Ile His Leu Leu         
                340                 345                 350             

aga atg gac cac agc caa ggg ctg gaa ctg cag gaa gtg gca gca ttc     1406
Arg Met Asp His Ser Gln Gly Leu Glu Leu Gln Glu Val Ala Ala Phe         
            355                 360                 365                 

tga ggccaagaga cactcactgg acaatatcaa accatggctc ctcctcagca          1459

tggctttgtg tctttcccag ttatcttgag gggagtggga tgtagggctg gtattctttg   1519

cttaggttca tttacaagat gtatcagtgt tgtaagtcca ataatttaag tccagtgatt   1579

caaaatcagg tatagagtcc agaaacatgg actacacata aggttctcta tttaagttaa   1639

atacaaatgc aactttttag tgagctttta ggactactct tcaaaaaaag tgtattgctc   1699

agaatgatga cctgtaaatg taagagtggc aggcctctgt ctgtgaaagt cagaacacag   1759

ggctcgagcc tctggaactg accctttgca agtctttaca aaagaaaaaa ggcagtgggg   1819

agagagagtg ttttggttac atcagaaata attgagatgg gaaagaatag tgcagctcca   1879

tagaggagac ggactgtaga caatgagatt aagcttcaat cactgctcct cagcaatgtg   1939

aagaatcaaa gtcagggcaa gaaagcgaaa gcttggactt ctattcaaag tggcagcaga   1999

gtgggagggc ggtacccttc tagcccagtg ctgctgagct tgtgtgaaaa tcagacctga   2059

gatggcttga agcagccaag aaccacatgg gcattgccca gaattacagg agttagcaca   2119

ccagctctac agataagaaa acattgaaat tcaaagatta aggccaaaaa tatctcactt   2179

gcaattttaa tattttcatt tggatttata taaatgaaac atatatatgt tttggaatgg   2239

ccagagtgag gcaaagggga tccctgaaat aacattagaa catacaggaa aaacgaggca   2299

ggcagatcac tttaggtcag gagttcaaga ccagcctgta cgtgcgtgcc tgtagtccca   2359

gctactcggg agggtgagat gggagaatca cttgaacctg ggaggcagag tttgcagtga   2419

gctgagattg tgccactgca ctccagtctg tgtgacagaa tgagaccttg tcttgaaaaa   2479

aaaaaaaaaa aaa                                                      2492


<210>  36
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Leu Leu Leu Arg Cys Gln Leu Lys Gln Ala Pro Pro Gln Lys Val 
1               5                   10                  15      


Ser Phe Arg Phe Cys Val Val Met Gly Lys Gln Gln Ser Lys Leu Lys 
            20                  25                  30          


His Ser Thr Tyr Lys Tyr Gly Arg Pro Asp Glu Ile Ile Glu Glu Arg 
        35                  40                  45              


Ile Gln Thr Lys Ala Phe Gln Glu Tyr Ser Pro Ala His Met Asp Thr 
    50                  55                  60                  


Val Ser Val Val Ala Ala Leu Asn Ser Asp Leu Cys Val Ser Gly Gly 
65                  70                  75                  80  


Lys Asp Lys Thr Val Val Ala Tyr Asn Trp Lys Thr Gly Asn Val Val 
                85                  90                  95      


Lys Arg Phe Lys Gly His Glu His Glu Ile Thr Lys Val Ala Cys Ile 
            100                 105                 110         


Pro Lys Ser Ser Gln Phe Phe Ser Ala Ser Arg Asp Arg Met Val Met 
        115                 120                 125             


Met Trp Asp Leu His Gly Ser Ser Gln Pro Arg Gln Gln Leu Cys Gly 
    130                 135                 140                 


His Ala Met Val Val Thr Gly Leu Ala Val Ser Pro Asp Ser Ser Gln 
145                 150                 155                 160 


Leu Cys Thr Gly Ser Arg Asp Asn Thr Leu Leu Leu Trp Asp Val Val 
                165                 170                 175     


Thr Gly Gln Ser Val Glu Arg Ala Ser Val Ser Arg Asn Val Val Thr 
            180                 185                 190         


His Leu Cys Trp Val Pro Arg Glu Pro Tyr Ile Leu Gln Thr Ser Glu 
        195                 200                 205             


Asp Lys Thr Leu Arg Leu Trp Asp Ser Arg Gly Leu Gln Val Ala His 
    210                 215                 220                 


Met Phe Pro Ala Lys Gln His Ile Gln Thr Tyr Cys Glu Val Ser Val 
225                 230                 235                 240 


Asp Gly His Lys Cys Ile Ser Cys Ser Asn Gly Phe Gly Gly Glu Gly 
                245                 250                 255     


Cys Glu Ala Thr Leu Trp Asp Leu Arg Gln Thr Arg Asn Arg Ile Cys 
            260                 265                 270         


Glu Tyr Lys Gly His Phe Gln Thr Val Ala Ser Cys Val Phe Leu Pro 
        275                 280                 285             


Arg Ala Leu Ala Leu Met Pro Leu Ile Ala Thr Ser Ser His Asp Cys 
    290                 295                 300                 


Lys Val Lys Ile Trp Asn Gln Asp Thr Gly Ala Cys Leu Phe Thr Leu 
305                 310                 315                 320 


Ser Leu Asp Gly Ser Gly Pro Leu Thr Ser Leu Ala Val Gly Asp Ala 
                325                 330                 335     


Ile Ser Leu Leu Cys Ala Ser Phe Asn Arg Gly Ile His Leu Leu Arg 
            340                 345                 350         


Met Asp His Ser Gln Gly Leu Glu Leu Gln Glu Val Ala Ala Phe 
        355                 360                 365         


<210>  37
<211>  3288
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (267)..(653)
<223>  

<400>  37
gaagtgtttg gtgcacaaac tgaattttga aatatttaaa ttttctttca tttgcttaca     60

gctatttgta cagtttattg taagataaga atgaaaatca ggtgttaaag caaagagtac    120

aaaactattc tatgtcctgt ctcttttcag ttgcttctcc aagcattaga cttctctagg    180

caaagtcctt tcataacact agagattcat tatatttggt agttcatgaa attttaacaa    240

gacacacttc tgtttgtggg attgga atg cgt gtt ggt gag tgt ccg aat tta     293
                             Met Arg Val Gly Glu Cys Pro Asn Leu        
                             1               5                          

aat ata ttg gta ttc ata tgg att cag gat tta ttt tca aag aac aga      341
Asn Ile Leu Val Phe Ile Trp Ile Gln Asp Leu Phe Ser Lys Asn Arg         
10                  15                  20                  25          

tat tca cta gac caa act aac ctg tac tca aac ttg aaa gaa ata gaa      389
Tyr Ser Leu Asp Gln Thr Asn Leu Tyr Ser Asn Leu Lys Glu Ile Glu         
                30                  35                  40              

ata gaa aaa gca gag gat aac ttt gta gag tta att cct gat ata ctg      437
Ile Glu Lys Ala Glu Asp Asn Phe Val Glu Leu Ile Pro Asp Ile Leu         
            45                  50                  55                  

gtc tct aaa gtt tct tgt tgt ccg ata aat att aat tta gca cct gct      485
Val Ser Lys Val Ser Cys Cys Pro Ile Asn Ile Asn Leu Ala Pro Ala         
        60                  65                  70                      

ggg ttt cag gca gga act gtg gaa gaa ctt ata aag ggt atg aaa atg      533
Gly Phe Gln Ala Gly Thr Val Glu Glu Leu Ile Lys Gly Met Lys Met         
    75                  80                  85                          

agt ata tca aga ttt ctg tac tca agt tat ata cag tta gct gta ggt      581
Ser Ile Ser Arg Phe Leu Tyr Ser Ser Tyr Ile Gln Leu Ala Val Gly         
90                  95                  100                 105         

gat aag aca ggt atg gtg aca gct aaa ata caa tca gac ttc cat aaa      629
Asp Lys Thr Gly Met Val Thr Ala Lys Ile Gln Ser Asp Phe His Lys         
                110                 115                 120             

aga ggt gaa ggg aga cga gaa tga ttatgattgt ttaaagagga acagatcaca     683
Arg Gly Glu Gly Arg Arg Glu                                             
            125                                                         

tggtgttgag aaaaccgact tagttgtccc aaaaggtttt ctgagcttgt ttcggaaagg    743

aagactggac ttttagcagg tgaatatgac agcatgaagg gtaagccaat atagaagaaa    803

caatgtaaga ttacaagggg cattttcagg atataggaaa gagaaaagct tgatgaaaag    863

ttaggtatag tatagtatgg ggagctaaga cttgacataa aggttaggat aattttctaa    923

aatgtttatt tgaaaaactt tatctcagaa ggaaataggg aaccattcca ggatttgggc    983

aaaggataat ttgatgaaac ctttaatagg gttaatatga ccatcttaca taggttgaca   1043

tggaaaggag gtggacgggg ttgaggtgac gaagactcat tagtaggctg atctcttact   1103

ctatgagtaa taacagggag cctacactag gataatgatg ttgggaagtg atttctgtag   1163

ctatgctgag cagacagtct tcaagagtta gcaaagttta tatgtgcggg tgacaaaaaa   1223

gaggctttga gttttgatga ctgaaaggag acaaataata gctaatcttt gataaagact   1283

aactatgggc aaggctttac tctttgtttg tagtaactta cttaatcctc attataaccc   1343

ctttatatag atgctgtatt ttctccattt tacagagagg aagtagagcc tcagagatgt   1403

tatgtcactt gtcaaaagtc acccagctag tgaatggctg gatcaaactg gatcatgtcc   1463

aagtagcctg ggcaacagag cgagactgtc tcaaaaaaga gaaaaaaaag aaaaaaaaaa   1523

agaaagcctg agagaattgg gttttatggt tacaaataaa ttttaggcca gtttacaagt   1583

gcagaatctc taaatagtga ggattggcta tatgtgtttt ctcaaatatc agttcttttc   1643

gtgtgccttg gtctttatct tctgcgccac ttgtttttct tgggtgtctg ctgatctttg   1703

cttatttata tttatgagtg agtgactgtt actgctatta gagcaaactg gtattggcat   1763

ttttctcctg ctgggtgctc tgttgtgtta acaacttact ctcttaacta gggaggctga   1823

ctgaattttg tggaatgggt ggagtgggtt gacagggttt cctaaggatg tgtgagccaa   1883

gagcaggctg gggcaccctc caactgacaa agcaagaaag attttccgtt gagcacgatg   1943

aaccattggg gcgcagttcc ttcctccctg cccctttccc tgttggtttt ggagtgctcc   2003

tttatttcca gctcttacct tttctttttc aagttctaat tgtctcacta agacaatgtt   2063

ttttgaccaa atcactccat gattgtccgt gactcattta tattctttgc atttattaat   2123

tggaggttgg accttctgga attttctact tactgatggt gatacggact cttttttcct   2183

ttgtattttc tttctcagtc tgatctgctt cctgacttcc tggaaaccct ccaaatttct   2243

tgatttctaa tggcactctt tctagatttc tagccctgta cgataatatt ctttcatcat   2303

ttcagtgggc ttttggaggg aggcggagat ccaggtgata tgtctacact attcagtcag   2363

aaagctggat ggtttttctc actgtttagc tgtgactcat acttagaaag tggtttaaat   2423

gtgaatatct tagttctggt tgtacaattg aggtaatcct caattcaggt tgctgtctgg   2483

acatttcatg actggattta aaaatatttt taaggccagg tggggtggct cacgtaattc   2543

cagcactttg aaaggctgag gcgggcagat cacctaaggt cgggagttcg agaccagtct   2603

gaccaacatg gagaaaaccc ctctctacta aaaatacaaa attagctggg tttggtggca   2663

catgcctgta atgctagcta ctcaggaggc tgaggcagga gaatcattga acctgggagg   2723

tggaggttgc ggtgagctga aatcacgcca ttgcactcca ccctgggcat caagagcaaa   2783

actctgtacc cgcccccccc ccccccccca cctcaccaaa aagaaaaaac aacaaagaat   2843

ttttaaaatc tcacattttt ttagctgggt gtggtggtgc acacctggaa tcccagctac   2903

ttgggaggag gattgcttga gcccagaagt tcaagtccag cctgggcaac atagtgagac   2963

tccagtctca attaaaaaaa aaaatcttgg ccaggcatgg ttgtttacgc ctgtaatccc   3023

agcactttgg gaggccgagg tgggcggatc atgaggtcag gagatcaaga ccatcctggc   3083

caacatggtg aaaccttatc tttactaaag atacaaaaat tagctgggcg tggtggcgcg   3143

tgcctgtgat cccagccact tgggaggccg aggcacgaga atcgcttgaa tccaggagat   3203

ggaggttgca gtgagccgag atcatgccac tgcactccag cctggcgaca gagtgagact   3263

ccatctcaaa aaaaaaaaaa aaaaa                                         3288


<210>  38
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Arg Val Gly Glu Cys Pro Asn Leu Asn Ile Leu Val Phe Ile Trp 
1               5                   10                  15      


Ile Gln Asp Leu Phe Ser Lys Asn Arg Tyr Ser Leu Asp Gln Thr Asn 
            20                  25                  30          


Leu Tyr Ser Asn Leu Lys Glu Ile Glu Ile Glu Lys Ala Glu Asp Asn 
        35                  40                  45              


Phe Val Glu Leu Ile Pro Asp Ile Leu Val Ser Lys Val Ser Cys Cys 
    50                  55                  60                  


Pro Ile Asn Ile Asn Leu Ala Pro Ala Gly Phe Gln Ala Gly Thr Val 
65                  70                  75                  80  


Glu Glu Leu Ile Lys Gly Met Lys Met Ser Ile Ser Arg Phe Leu Tyr 
                85                  90                  95      


Ser Ser Tyr Ile Gln Leu Ala Val Gly Asp Lys Thr Gly Met Val Thr 
            100                 105                 110         


Ala Lys Ile Gln Ser Asp Phe His Lys Arg Gly Glu Gly Arg Arg Glu 
        115                 120                 125             


<210>  39
<211>  6956
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (322)..(4335)
<223>  

<400>  39
gacgaggccg gaggagcttc gaggctgctc ttcctcggcc agacggagag cggcactgtc     60

tccccgccca gcgctcactc gccccgcgtc tccccccgcg gcggctgctc ctcctcggca    120

ccgccagccc cagcgccgct cccgggcggg cgggcggcgg cggcggcggc ggcggcggga    180

cccgcggagc cgctttgtgt gcagcccgac taggggcggc ggcgcaacca cctgacagag    240

gcccgggcgc tcgatgcacc ttccgcccgc atgaggagga gaggccggta gaggactgtg    300

aaccaaaagt tgtcccccag g atg gac ttc acc gcg cag ccc aag cct gcc      351
                        Met Asp Phe Thr Ala Gln Pro Lys Pro Ala         
                        1               5                   10          

act gcc ctc tgt ggc gtc gtg agt gcc gac ggg aag atc gct tac cct      399
Thr Ala Leu Cys Gly Val Val Ser Ala Asp Gly Lys Ile Ala Tyr Pro         
                15                  20                  25              

ccg ggg gta aaa gag atc acc gac aag atc acc acg gac gag atg atc      447
Pro Gly Val Lys Glu Ile Thr Asp Lys Ile Thr Thr Asp Glu Met Ile         
            30                  35                  40                  

aaa cgc ctg aag atg gta gtg aaa acc ttt atg gat atg gat cag gac      495
Lys Arg Leu Lys Met Val Val Lys Thr Phe Met Asp Met Asp Gln Asp         
        45                  50                  55                      

tca gaa gat gaa aaa cag cag tat ctc cca cta gcc ttg cat ctt gca      543
Ser Glu Asp Glu Lys Gln Gln Tyr Leu Pro Leu Ala Leu His Leu Ala         
    60                  65                  70                          

tct gaa ttc ttc ctc agg aac ccc aat aaa gat gtg cgt ctc ctt gta      591
Ser Glu Phe Phe Leu Arg Asn Pro Asn Lys Asp Val Arg Leu Leu Val         
75                  80                  85                  90          

gca tgt tgt ttg gct gat atc ttt cgt atc tat gcc cca gaa gct cca      639
Ala Cys Cys Leu Ala Asp Ile Phe Arg Ile Tyr Ala Pro Glu Ala Pro         
                95                  100                 105             

tat act tcc cat gat aaa ctt aag gac ata ttt ttg ttt att acc aga      687
Tyr Thr Ser His Asp Lys Leu Lys Asp Ile Phe Leu Phe Ile Thr Arg         
            110                 115                 120                 

caa tta aaa ggt ttg gag gat aca aag agt cca cag ttt aat aga tac      735
Gln Leu Lys Gly Leu Glu Asp Thr Lys Ser Pro Gln Phe Asn Arg Tyr         
        125                 130                 135                     

ttt tat tta tta gag aat tta gct tgg gtt aaa tca tat aac atc tgc      783
Phe Tyr Leu Leu Glu Asn Leu Ala Trp Val Lys Ser Tyr Asn Ile Cys         
    140                 145                 150                         

ttt gaa ttg gaa gat tgc aat gaa att ttt att cag ctt ttt aga act      831
Phe Glu Leu Glu Asp Cys Asn Glu Ile Phe Ile Gln Leu Phe Arg Thr         
155                 160                 165                 170         

ctc ttc tca gtg atc aac aat agc cac aat aag aag gta caa atg cac      879
Leu Phe Ser Val Ile Asn Asn Ser His Asn Lys Lys Val Gln Met His         
                175                 180                 185             

atg cta gat ttg atg agt tct atc atc atg gaa ggt gat gga gtt act      927
Met Leu Asp Leu Met Ser Ser Ile Ile Met Glu Gly Asp Gly Val Thr         
            190                 195                 200                 

caa gaa tta ttg gac tcc att ctt att aac ctc att cct gca cat aag      975
Gln Glu Leu Leu Asp Ser Ile Leu Ile Asn Leu Ile Pro Ala His Lys         
        205                 210                 215                     

aac tta aat aaa cag tcc ttt gac ctt gca aaa gtg cta ttg aaa aga     1023
Asn Leu Asn Lys Gln Ser Phe Asp Leu Ala Lys Val Leu Leu Lys Arg         
    220                 225                 230                         

aca gtc cag act att gag gca tgc att gct aat ttt ttc aat caa gtc     1071
Thr Val Gln Thr Ile Glu Ala Cys Ile Ala Asn Phe Phe Asn Gln Val         
235                 240                 245                 250         

ctg gtg ctg gga aga tca tca gta agt gat ttg tca gaa cat gta ttt     1119
Leu Val Leu Gly Arg Ser Ser Val Ser Asp Leu Ser Glu His Val Phe         
                255                 260                 265             

gat ctg att cag gaa ctt ttt gct ata gat cct cat tta tta tta tcc     1167
Asp Leu Ile Gln Glu Leu Phe Ala Ile Asp Pro His Leu Leu Leu Ser         
            270                 275                 280                 

gtc atg cca cag ctt gaa ttc aaa cta aag agc aat gat gga gaa gag     1215
Val Met Pro Gln Leu Glu Phe Lys Leu Lys Ser Asn Asp Gly Glu Glu         
        285                 290                 295                     

cga tta gct gtt gtt cga ctt cta gct aaa ttg ttt ggc tcc aaa gat     1263
Arg Leu Ala Val Val Arg Leu Leu Ala Lys Leu Phe Gly Ser Lys Asp         
    300                 305                 310                         

tct gat ttg gca aca cag aat cgt cct ctt tgg caa tgt ttt ctt gga     1311
Ser Asp Leu Ala Thr Gln Asn Arg Pro Leu Trp Gln Cys Phe Leu Gly         
315                 320                 325                 330         

cga ttt aat gat att cat gtt cct gtg aga tta gaa agt gtg aaa ttt     1359
Arg Phe Asn Asp Ile His Val Pro Val Arg Leu Glu Ser Val Lys Phe         
                335                 340                 345             

gcc agt cat tgt tta atg aat cac cca gat tta gcg aag gat ctc aca     1407
Ala Ser His Cys Leu Met Asn His Pro Asp Leu Ala Lys Asp Leu Thr         
            350                 355                 360                 

gaa tat tta aag gtt aga tca cat gat cca gaa gaa gct att cgt cat     1455
Glu Tyr Leu Lys Val Arg Ser His Asp Pro Glu Glu Ala Ile Arg His         
        365                 370                 375                     

gat gtc att gtt act ata ata aca gct gcc aag agg gac ctg gcc tta     1503
Asp Val Ile Val Thr Ile Ile Thr Ala Ala Lys Arg Asp Leu Ala Leu         
    380                 385                 390                         

gta aat gat cag ctg ctt ggc ttt gta agg gaa aga aca ctg gat aaa     1551
Val Asn Asp Gln Leu Leu Gly Phe Val Arg Glu Arg Thr Leu Asp Lys         
395                 400                 405                 410         

cgg tgg cga gta aga aaa gaa gct atg atg ggt ctg gct cag ctt tat     1599
Arg Trp Arg Val Arg Lys Glu Ala Met Met Gly Leu Ala Gln Leu Tyr         
                415                 420                 425             

aag aaa tac tgt ctt cat ggt gaa gca gga aag gaa gct gca gag aaa     1647
Lys Lys Tyr Cys Leu His Gly Glu Ala Gly Lys Glu Ala Ala Glu Lys         
            430                 435                 440                 

gtc agc tgg ata aag gac aaa ctt ctg cat att tat tat cag aac agc     1695
Val Ser Trp Ile Lys Asp Lys Leu Leu His Ile Tyr Tyr Gln Asn Ser         
        445                 450                 455                     

att gac gac aaa ctg ttg gta gag aaa atc ttt gct cag tat ctt gtc     1743
Ile Asp Asp Lys Leu Leu Val Glu Lys Ile Phe Ala Gln Tyr Leu Val         
    460                 465                 470                         

ccc cac aac ctg gaa aca gaa gag aga atg aaa tgc tta tat tac tta     1791
Pro His Asn Leu Glu Thr Glu Glu Arg Met Lys Cys Leu Tyr Tyr Leu         
475                 480                 485                 490         

tat gct agt ttg gat cca aat gct gta aaa gct ctc aac gaa atg tgg     1839
Tyr Ala Ser Leu Asp Pro Asn Ala Val Lys Ala Leu Asn Glu Met Trp         
                495                 500                 505             

aag tgt cag aac atg ctt cgg agc cat gta cgc gaa cta ttg gat ttg     1887
Lys Cys Gln Asn Met Leu Arg Ser His Val Arg Glu Leu Leu Asp Leu         
            510                 515                 520                 

cac aag cag cct aca tca gag gct aac tgt tct gcc atg ttt gga aaa     1935
His Lys Gln Pro Thr Ser Glu Ala Asn Cys Ser Ala Met Phe Gly Lys         
        525                 530                 535                     

ctg atg acc ata gca aag aat ttg cct gac ccc ggg aaa gca caa gat     1983
Leu Met Thr Ile Ala Lys Asn Leu Pro Asp Pro Gly Lys Ala Gln Asp         
    540                 545                 550                         

ttt gtg aag aaa ttt aac cag gtt ctc ggc gat gat gag aaa ctt cgg     2031
Phe Val Lys Lys Phe Asn Gln Val Leu Gly Asp Asp Glu Lys Leu Arg         
555                 560                 565                 570         

tct cag ttg gag tta tta att agc cca acc tgt tct tgc aaa caa gca     2079
Ser Gln Leu Glu Leu Leu Ile Ser Pro Thr Cys Ser Cys Lys Gln Ala         
                575                 580                 585             

gat att tgt gtg aga gaa ata gcc cgg aaa ctt gca aat cct aag caa     2127
Asp Ile Cys Val Arg Glu Ile Ala Arg Lys Leu Ala Asn Pro Lys Gln         
            590                 595                 600                 

cca aca aat cct ttt cta gag atg gtc aaa ttt ctg ttg gaa aga atc     2175
Pro Thr Asn Pro Phe Leu Glu Met Val Lys Phe Leu Leu Glu Arg Ile         
        605                 610                 615                     

gca cct gtg cac att gat tca gaa gcc ata agt gca cta gtg aaa ttg     2223
Ala Pro Val His Ile Asp Ser Glu Ala Ile Ser Ala Leu Val Lys Leu         
    620                 625                 630                         

atg aat aag tca ata gag ggg aca gca gat gat gaa gag gag ggt gta     2271
Met Asn Lys Ser Ile Glu Gly Thr Ala Asp Asp Glu Glu Glu Gly Val         
635                 640                 645                 650         

agt cca gat aca gct atc cgt tca gga ctt gaa ctt ctt aag gtt ctg     2319
Ser Pro Asp Thr Ala Ile Arg Ser Gly Leu Glu Leu Leu Lys Val Leu         
                655                 660                 665             

tct ttt aca cat cct acc tcg ttc cac tct gca gag aca tat gag tcc     2367
Ser Phe Thr His Pro Thr Ser Phe His Ser Ala Glu Thr Tyr Glu Ser         
            670                 675                 680                 

ttg tta cag tgc cta aga atg gag gat gac aag gta gca gaa gct gct     2415
Leu Leu Gln Cys Leu Arg Met Glu Asp Asp Lys Val Ala Glu Ala Ala         
        685                 690                 695                     

att caa att ttt aga aat aca ggt cac aaa ata gaa aca gac ctt ccc     2463
Ile Gln Ile Phe Arg Asn Thr Gly His Lys Ile Glu Thr Asp Leu Pro         
    700                 705                 710                         

cag ata cga tcg acc tta att ccc att tta cat caa aaa gca aag agg     2511
Gln Ile Arg Ser Thr Leu Ile Pro Ile Leu His Gln Lys Ala Lys Arg         
715                 720                 725                 730         

ggt act cca cac caa gca aaa cag gct gtg cac tgt ata cac gcc ata     2559
Gly Thr Pro His Gln Ala Lys Gln Ala Val His Cys Ile His Ala Ile         
                735                 740                 745             

ttc aca aat aaa gaa gtc cag ctt gca cag att ttt gag cca ctc agt     2607
Phe Thr Asn Lys Glu Val Gln Leu Ala Gln Ile Phe Glu Pro Leu Ser         
            750                 755                 760                 

agg agt ctg aat gct gat gtg cca gaa caa ctt ata act cca tta gtt     2655
Arg Ser Leu Asn Ala Asp Val Pro Glu Gln Leu Ile Thr Pro Leu Val         
        765                 770                 775                     

tca ttg ggc cac att tct atg tta gca cca gat cag ttt gct tcc cca     2703
Ser Leu Gly His Ile Ser Met Leu Ala Pro Asp Gln Phe Ala Ser Pro         
    780                 785                 790                         

atg aaa tct gta gta gca aat ttt att gtg aaa gat ctg cta atg aat     2751
Met Lys Ser Val Val Ala Asn Phe Ile Val Lys Asp Leu Leu Met Asn         
795                 800                 805                 810         

gac agg tca aca ggt gaa aag aat gga aaa ctg tgg tct cca gat gaa     2799
Asp Arg Ser Thr Gly Glu Lys Asn Gly Lys Leu Trp Ser Pro Asp Glu         
                815                 820                 825             

gag gtt tcc cct gaa gta cta gca aag gta cag gca att aaa ctt ctg     2847
Glu Val Ser Pro Glu Val Leu Ala Lys Val Gln Ala Ile Lys Leu Leu         
            830                 835                 840                 

gta agg tgg ctg ttg ggt atg aaa aac aac cag tct aaa tct gcc aat     2895
Val Arg Trp Leu Leu Gly Met Lys Asn Asn Gln Ser Lys Ser Ala Asn         
        845                 850                 855                     

tca acc ctt cgg tta tta tca gcg atg ttg gtt agt gag ggt gac ctg     2943
Ser Thr Leu Arg Leu Leu Ser Ala Met Leu Val Ser Glu Gly Asp Leu         
    860                 865                 870                         

aca gag caa aag agg atc agt aaa tct gat atg tct cgc ttg cga tta     2991
Thr Glu Gln Lys Arg Ile Ser Lys Ser Asp Met Ser Arg Leu Arg Leu         
875                 880                 885                 890         

gct gct ggt agt gcc ata atg aag ctt gct cag gaa cct tgt tac cat     3039
Ala Ala Gly Ser Ala Ile Met Lys Leu Ala Gln Glu Pro Cys Tyr His         
                895                 900                 905             

gaa att att acc cca gaa cag ttt cag ctc tgt gca ctt gtt att aat     3087
Glu Ile Ile Thr Pro Glu Gln Phe Gln Leu Cys Ala Leu Val Ile Asn         
            910                 915                 920                 

gat gag tgt tac caa gta agg cag ata ttt gct cag aag ctg cat aag     3135
Asp Glu Cys Tyr Gln Val Arg Gln Ile Phe Ala Gln Lys Leu His Lys         
        925                 930                 935                     

gca ctt gtg aag tta ctg ctc cca ttg gag tat atg gcg atc ttt gcc     3183
Ala Leu Val Lys Leu Leu Leu Pro Leu Glu Tyr Met Ala Ile Phe Ala         
    940                 945                 950                         

ttg tgt gcc aaa gat cct gtg aag gag aga aga gca cac gca cga caa     3231
Leu Cys Ala Lys Asp Pro Val Lys Glu Arg Arg Ala His Ala Arg Gln         
955                 960                 965                 970         

tgt tta ctg aaa aat atc agt ata cgc agg gaa tac att aag cag aat     3279
Cys Leu Leu Lys Asn Ile Ser Ile Arg Arg Glu Tyr Ile Lys Gln Asn         
                975                 980                 985             

cct atg gct act gag aaa tta tta tca ctg ttg cct gaa tat  gta gtt    3327
Pro Met Ala Thr Glu Lys Leu Leu Ser Leu Leu Pro Glu Tyr  Val Val        
            990                 995                 1000                

cca tac atg  att cac ctg cta gcc  cat gat cca gat ttt  aca aga      3372
Pro Tyr Met  Ile His Leu Leu Ala  His Asp Pro Asp Phe  Thr Arg          
        1005                 1010                 1015                  

tca caa gat  gtt gat cag ctt cgt  gat atc aaa gag tgc  cta tgg      3417
Ser Gln Asp  Val Asp Gln Leu Arg  Asp Ile Lys Glu Cys  Leu Trp          
        1020                 1025                 1030                  

ttc atg ctt  gaa gtt tta atg aca  aag aat gaa aac aat  agc cat      3462
Phe Met Leu  Glu Val Leu Met Thr  Lys Asn Glu Asn Asn  Ser His          
        1035                 1040                 1045                  

gcc ttt atg  aag aag atg gca gag  aac atc aag tta acc  aga gat      3507
Ala Phe Met  Lys Lys Met Ala Glu  Asn Ile Lys Leu Thr  Arg Asp          
        1050                 1055                 1060                  

gcc cag tct  cca gat gaa tcc aag  aca aat gaa aaa ctg  tat aca      3552
Ala Gln Ser  Pro Asp Glu Ser Lys  Thr Asn Glu Lys Leu  Tyr Thr          
        1065                 1070                 1075                  

gta tgt gat  gtg gct ctc tgt gtt  ata aat agt aaa agt  gct ttg      3597
Val Cys Asp  Val Ala Leu Cys Val  Ile Asn Ser Lys Ser  Ala Leu          
        1080                 1085                 1090                  

tgc aat gca  gat tca cca aag gac  cca gtc ctc cca atg  aaa ttt      3642
Cys Asn Ala  Asp Ser Pro Lys Asp  Pro Val Leu Pro Met  Lys Phe          
        1095                 1100                 1105                  

ttt aca caa  cct gaa aag gac ttc  tgt aac gat aag agt  tat att      3687
Phe Thr Gln  Pro Glu Lys Asp Phe  Cys Asn Asp Lys Ser  Tyr Ile          
        1110                 1115                 1120                  

tca gaa gag  aca aga gta ctt ctg  tta aca gga aag cca  aag cct      3732
Ser Glu Glu  Thr Arg Val Leu Leu  Leu Thr Gly Lys Pro  Lys Pro          
        1125                 1130                 1135                  

gct gga gta  cta ggt gca gta aat  aag cct tta tca gca  acg gga      3777
Ala Gly Val  Leu Gly Ala Val Asn  Lys Pro Leu Ser Ala  Thr Gly          
        1140                 1145                 1150                  

agg aaa ccc  tat gtt aga agc act  ggc act gag act gga  agc aat      3822
Arg Lys Pro  Tyr Val Arg Ser Thr  Gly Thr Glu Thr Gly  Ser Asn          
        1155                 1160                 1165                  

att aat gta  aat tca gag ctg aac  cct tca acc gga aat  cga tca      3867
Ile Asn Val  Asn Ser Glu Leu Asn  Pro Ser Thr Gly Asn  Arg Ser          
        1170                 1175                 1180                  

agg gaa cag  agt tca gag gca gca  gaa act gga gtt agt  gaa aat      3912
Arg Glu Gln  Ser Ser Glu Ala Ala  Glu Thr Gly Val Ser  Glu Asn          
        1185                 1190                 1195                  

gaa gag aac  cct gtg agg att att  tca gtc aca cct gta  aag aat      3957
Glu Glu Asn  Pro Val Arg Ile Ile  Ser Val Thr Pro Val  Lys Asn          
        1200                 1205                 1210                  

att gac cca  gta aag aat aag gaa  att aat tct gat cag  gct acc      4002
Ile Asp Pro  Val Lys Asn Lys Glu  Ile Asn Ser Asp Gln  Ala Thr          
        1215                 1220                 1225                  

cag ggc aac  atc agc agt gac cga  gga aag aaa aga aca  gta aca      4047
Gln Gly Asn  Ile Ser Ser Asp Arg  Gly Lys Lys Arg Thr  Val Thr          
        1230                 1235                 1240                  

gca gct ggt  gca gag aat atc caa  caa aaa aca gat gag  aaa gta      4092
Ala Ala Gly  Ala Glu Asn Ile Gln  Gln Lys Thr Asp Glu  Lys Val          
        1245                 1250                 1255                  

gat gaa tcg  gga cct ccc gcc cct  tcc aaa ccc agg aga  gga cgt      4137
Asp Glu Ser  Gly Pro Pro Ala Pro  Ser Lys Pro Arg Arg  Gly Arg          
        1260                 1265                 1270                  

cga ccc aag  tct gaa tct cag ggc  aat gct acc aaa aat  gat gat      4182
Arg Pro Lys  Ser Glu Ser Gln Gly  Asn Ala Thr Lys Asn  Asp Asp          
        1275                 1280                 1285                  

cta aat aaa  cct att aac aag gga  agg aag aga gct gca  gtg ggt      4227
Leu Asn Lys  Pro Ile Asn Lys Gly  Arg Lys Arg Ala Ala  Val Gly          
        1290                 1295                 1300                  

cag gag agc  cct ggg ggt ttg gaa  gca ggt aat gcc aaa  gca ccc      4272
Gln Glu Ser  Pro Gly Gly Leu Glu  Ala Gly Asn Ala Lys  Ala Pro          
        1305                 1310                 1315                  

aaa ctg caa  gat tta gcc aaa aag  gca gca cca gca gaa  aga caa      4317
Lys Leu Gln  Asp Leu Ala Lys Lys  Ala Ala Pro Ala Glu  Arg Gln          
        1320                 1325                 1330                  

att gac tta  caa agg taa aaatgcattt gcaaagggag aaaatgaagg           4365
Ile Asp Leu  Gln Arg                                                    
        1335                                                            

ccaaacagaa gcaggctcca gcttctgcaa aaacttggat tcacaaatgt ccctgaacag   4425

aaaatgaagc tcacttcaga acacacactc tctgccttga aaactaaaga gactattact   4485

tccttttcac atgaccacaa gtcctctgat ggaaatgtac agcagaaact cttgagagag   4545

aggctaaaag caactctgtt ctcccccttc ccctagactt ttcttacgaa aagtcaataa   4605

ttaagcaaat tgcttaacac ttggttccag ttcctgccta tctggagttt aaatgcgtaa   4665

tacaccatta atttccacgc tgcagttttt attttaaaga aagtaacaag atgtctttac   4725

actgacactg aaaattcatc cattttagag ccaggaattc ccatgttaca caggaaaaaa   4785

tagaagtcta ctgaattaat tttttaaaag aaaagagatc agattaaata tttctttgtt   4845

tttccttttg gaaactttta tgtataattc tttctgcctg cctacttttc tgcaaaaatg   4905

agatgtacag atttcggttc cctgctatga aaagtgatgt ggtagcaatt ttataaatgt   4965

tgctttctga tttttatcag agtgagaaaa ttaaaattat tgatttgcaa gtagtaaaca   5025

gttcatattt tgatttcccc tcattttagt ttaatataat ttgcaataaa tgtacatatt   5085

gttgtttgtt tcataaagca tatcacttta aaatggtttt tactcctgtg attatgttgg   5145

aatatttgga attttaaagg agtaaagact gtccagcatt tggttttata atgtttgtca   5205

ccagattttt attaatgtaa aaaaaatcaa tttttaaaaa atagttggac tttggcagct   5265

tttaaggaaa gttggaggtg ttttaggatt gctatcaatt ttcagcattg tgctatttgg   5325

aaataagtgt tttgcttttg tctgatggtc tgggctcatt tttatgttta ttttagaaaa   5385

ctgttgcatc aatatattat gtttcttggc attgttcagc ataggtaatg tgtgcacttt   5445

atgtgtacac ataatcatat ttaagttttt tgcataaaat aaatgcttct agatgtcatg   5505

gcagtctttt taatcttttt atcatatgct ttcttgtgaa ttttttcatg ttaaagagct   5565

aaagtcataa catgattaca gtcaactctc cattatctat ataaaatagt gactaagcct   5625

caggttttta attttgtgat aacaaaataa cgaaggcatg taagacctga ttctggagga   5685

acatgaaatt tgtcttttct catgtccaga gttctatcct gcccccactg tccactgtag   5745

ggtcatccgc aaagccctag cagaatgtgc tcactccatt tccttacacg tttctagcat   5805

gggtcagagg aaacaacatt tgtgttataa cttcgtcttg ataggctgta gtgtacatgg   5865

gatgtaaaac aaacaagtgt atcaaaggtg gatgattctg ttagagtgaa gtttgagagt   5925

aaatgtcact tacgtttctc atagataatc aagagttggc tgtgtattga ctgaaagatg   5985

ggtaattatt ttaaatatgc atttacacac atttaggtat cagaagatgc ttagggaaca   6045

atggatacca atgatagaaa atgatacctt tacaggggca gaaaaatccc cactcttcct   6105

tattgcctct tcagaaccct ttagaaagta taaaatattg cctccaacat gctgaaaaag   6165

agtatctatg cataagtatc agagaagtcc ctcaagcaat cagtaggtgt gttctattta   6225

gagagagttt aaagttctct tagcatcaga caacttgatt cctaaggttt ccagtgtgtc   6285

accaacaaaa agtgcattga tagggacctt tgtctcttcc tccctttgat taattgcccg   6345

gcatcacagt ttactagatt accaagtgtt acatcatatt aaataaaatg tagcagaacc   6405

atctgcatca atatattcct gtttagattt ttgcaggaga gaagttaaaa ggatttgctc   6465

cttgtatgat gtaagtggcc caccccaatt ttgtaacatg atgcaagtgt ctggcactaa   6525

gggaagcaag agtagggttg tggaaagacc aagctgatgg ggagggactt gtttacggga   6585

atttttttag ttttcctttt caaaggaaaa cattaaaatc ccttaggaat ttggtattca   6645

catctcagag aactacaaca caaaagtgca gacttatatt tgagaattaa tgttaaccct   6705

ttgtgtctag tttgaagctt cttgtatttg tctaaaacaa caagccagaa ttttgtatct   6765

cctttgataa aaagtgtgta taatgtaaag tagttttgca tattcttgtg ctgcacatgg   6825

gctgaatttt taaatttttt ttaaaaactt gaagcagaac cttgtaattt gtgtaaatga   6885

caagtgtaaa atcctaccat aaaatgctaa aaatatgcac tgtttcaaat aaaaccaaga   6945

aatgcagcat t                                                        6956


<210>  40
<211>  1337
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Asp Phe Thr Ala Gln Pro Lys Pro Ala Thr Ala Leu Cys Gly Val 
1               5                   10                  15      


Val Ser Ala Asp Gly Lys Ile Ala Tyr Pro Pro Gly Val Lys Glu Ile 
            20                  25                  30          


Thr Asp Lys Ile Thr Thr Asp Glu Met Ile Lys Arg Leu Lys Met Val 
        35                  40                  45              


Val Lys Thr Phe Met Asp Met Asp Gln Asp Ser Glu Asp Glu Lys Gln 
    50                  55                  60                  


Gln Tyr Leu Pro Leu Ala Leu His Leu Ala Ser Glu Phe Phe Leu Arg 
65                  70                  75                  80  


Asn Pro Asn Lys Asp Val Arg Leu Leu Val Ala Cys Cys Leu Ala Asp 
                85                  90                  95      


Ile Phe Arg Ile Tyr Ala Pro Glu Ala Pro Tyr Thr Ser His Asp Lys 
            100                 105                 110         


Leu Lys Asp Ile Phe Leu Phe Ile Thr Arg Gln Leu Lys Gly Leu Glu 
        115                 120                 125             


Asp Thr Lys Ser Pro Gln Phe Asn Arg Tyr Phe Tyr Leu Leu Glu Asn 
    130                 135                 140                 


Leu Ala Trp Val Lys Ser Tyr Asn Ile Cys Phe Glu Leu Glu Asp Cys 
145                 150                 155                 160 


Asn Glu Ile Phe Ile Gln Leu Phe Arg Thr Leu Phe Ser Val Ile Asn 
                165                 170                 175     


Asn Ser His Asn Lys Lys Val Gln Met His Met Leu Asp Leu Met Ser 
            180                 185                 190         


Ser Ile Ile Met Glu Gly Asp Gly Val Thr Gln Glu Leu Leu Asp Ser 
        195                 200                 205             


Ile Leu Ile Asn Leu Ile Pro Ala His Lys Asn Leu Asn Lys Gln Ser 
    210                 215                 220                 


Phe Asp Leu Ala Lys Val Leu Leu Lys Arg Thr Val Gln Thr Ile Glu 
225                 230                 235                 240 


Ala Cys Ile Ala Asn Phe Phe Asn Gln Val Leu Val Leu Gly Arg Ser 
                245                 250                 255     


Ser Val Ser Asp Leu Ser Glu His Val Phe Asp Leu Ile Gln Glu Leu 
            260                 265                 270         


Phe Ala Ile Asp Pro His Leu Leu Leu Ser Val Met Pro Gln Leu Glu 
        275                 280                 285             


Phe Lys Leu Lys Ser Asn Asp Gly Glu Glu Arg Leu Ala Val Val Arg 
    290                 295                 300                 


Leu Leu Ala Lys Leu Phe Gly Ser Lys Asp Ser Asp Leu Ala Thr Gln 
305                 310                 315                 320 


Asn Arg Pro Leu Trp Gln Cys Phe Leu Gly Arg Phe Asn Asp Ile His 
                325                 330                 335     


Val Pro Val Arg Leu Glu Ser Val Lys Phe Ala Ser His Cys Leu Met 
            340                 345                 350         


Asn His Pro Asp Leu Ala Lys Asp Leu Thr Glu Tyr Leu Lys Val Arg 
        355                 360                 365             


Ser His Asp Pro Glu Glu Ala Ile Arg His Asp Val Ile Val Thr Ile 
    370                 375                 380                 


Ile Thr Ala Ala Lys Arg Asp Leu Ala Leu Val Asn Asp Gln Leu Leu 
385                 390                 395                 400 


Gly Phe Val Arg Glu Arg Thr Leu Asp Lys Arg Trp Arg Val Arg Lys 
                405                 410                 415     


Glu Ala Met Met Gly Leu Ala Gln Leu Tyr Lys Lys Tyr Cys Leu His 
            420                 425                 430         


Gly Glu Ala Gly Lys Glu Ala Ala Glu Lys Val Ser Trp Ile Lys Asp 
        435                 440                 445             


Lys Leu Leu His Ile Tyr Tyr Gln Asn Ser Ile Asp Asp Lys Leu Leu 
    450                 455                 460                 


Val Glu Lys Ile Phe Ala Gln Tyr Leu Val Pro His Asn Leu Glu Thr 
465                 470                 475                 480 


Glu Glu Arg Met Lys Cys Leu Tyr Tyr Leu Tyr Ala Ser Leu Asp Pro 
                485                 490                 495     


Asn Ala Val Lys Ala Leu Asn Glu Met Trp Lys Cys Gln Asn Met Leu 
            500                 505                 510         


Arg Ser His Val Arg Glu Leu Leu Asp Leu His Lys Gln Pro Thr Ser 
        515                 520                 525             


Glu Ala Asn Cys Ser Ala Met Phe Gly Lys Leu Met Thr Ile Ala Lys 
    530                 535                 540                 


Asn Leu Pro Asp Pro Gly Lys Ala Gln Asp Phe Val Lys Lys Phe Asn 
545                 550                 555                 560 


Gln Val Leu Gly Asp Asp Glu Lys Leu Arg Ser Gln Leu Glu Leu Leu 
                565                 570                 575     


Ile Ser Pro Thr Cys Ser Cys Lys Gln Ala Asp Ile Cys Val Arg Glu 
            580                 585                 590         


Ile Ala Arg Lys Leu Ala Asn Pro Lys Gln Pro Thr Asn Pro Phe Leu 
        595                 600                 605             


Glu Met Val Lys Phe Leu Leu Glu Arg Ile Ala Pro Val His Ile Asp 
    610                 615                 620                 


Ser Glu Ala Ile Ser Ala Leu Val Lys Leu Met Asn Lys Ser Ile Glu 
625                 630                 635                 640 


Gly Thr Ala Asp Asp Glu Glu Glu Gly Val Ser Pro Asp Thr Ala Ile 
                645                 650                 655     


Arg Ser Gly Leu Glu Leu Leu Lys Val Leu Ser Phe Thr His Pro Thr 
            660                 665                 670         


Ser Phe His Ser Ala Glu Thr Tyr Glu Ser Leu Leu Gln Cys Leu Arg 
        675                 680                 685             


Met Glu Asp Asp Lys Val Ala Glu Ala Ala Ile Gln Ile Phe Arg Asn 
    690                 695                 700                 


Thr Gly His Lys Ile Glu Thr Asp Leu Pro Gln Ile Arg Ser Thr Leu 
705                 710                 715                 720 


Ile Pro Ile Leu His Gln Lys Ala Lys Arg Gly Thr Pro His Gln Ala 
                725                 730                 735     


Lys Gln Ala Val His Cys Ile His Ala Ile Phe Thr Asn Lys Glu Val 
            740                 745                 750         


Gln Leu Ala Gln Ile Phe Glu Pro Leu Ser Arg Ser Leu Asn Ala Asp 
        755                 760                 765             


Val Pro Glu Gln Leu Ile Thr Pro Leu Val Ser Leu Gly His Ile Ser 
    770                 775                 780                 


Met Leu Ala Pro Asp Gln Phe Ala Ser Pro Met Lys Ser Val Val Ala 
785                 790                 795                 800 


Asn Phe Ile Val Lys Asp Leu Leu Met Asn Asp Arg Ser Thr Gly Glu 
                805                 810                 815     


Lys Asn Gly Lys Leu Trp Ser Pro Asp Glu Glu Val Ser Pro Glu Val 
            820                 825                 830         


Leu Ala Lys Val Gln Ala Ile Lys Leu Leu Val Arg Trp Leu Leu Gly 
        835                 840                 845             


Met Lys Asn Asn Gln Ser Lys Ser Ala Asn Ser Thr Leu Arg Leu Leu 
    850                 855                 860                 


Ser Ala Met Leu Val Ser Glu Gly Asp Leu Thr Glu Gln Lys Arg Ile 
865                 870                 875                 880 


Ser Lys Ser Asp Met Ser Arg Leu Arg Leu Ala Ala Gly Ser Ala Ile 
                885                 890                 895     


Met Lys Leu Ala Gln Glu Pro Cys Tyr His Glu Ile Ile Thr Pro Glu 
            900                 905                 910         


Gln Phe Gln Leu Cys Ala Leu Val Ile Asn Asp Glu Cys Tyr Gln Val 
        915                 920                 925             


Arg Gln Ile Phe Ala Gln Lys Leu His Lys Ala Leu Val Lys Leu Leu 
    930                 935                 940                 


Leu Pro Leu Glu Tyr Met Ala Ile Phe Ala Leu Cys Ala Lys Asp Pro 
945                 950                 955                 960 


Val Lys Glu Arg Arg Ala His Ala Arg Gln Cys Leu Leu Lys Asn Ile 
                965                 970                 975     


Ser Ile Arg Arg Glu Tyr Ile Lys Gln Asn Pro Met Ala Thr Glu Lys 
            980                 985                 990         


Leu Leu Ser Leu Leu Pro Glu Tyr  Val Val Pro Tyr Met  Ile His Leu 
        995                 1000                 1005             


Leu Ala  His Asp Pro Asp Phe  Thr Arg Ser Gln Asp  Val Asp Gln 
    1010                 1015                 1020             


Leu Arg  Asp Ile Lys Glu Cys  Leu Trp Phe Met Leu  Glu Val Leu 
    1025                 1030                 1035             


Met Thr  Lys Asn Glu Asn Asn  Ser His Ala Phe Met  Lys Lys Met 
    1040                 1045                 1050             


Ala Glu  Asn Ile Lys Leu Thr  Arg Asp Ala Gln Ser  Pro Asp Glu 
    1055                 1060                 1065             


Ser Lys  Thr Asn Glu Lys Leu  Tyr Thr Val Cys Asp  Val Ala Leu 
    1070                 1075                 1080             


Cys Val  Ile Asn Ser Lys Ser  Ala Leu Cys Asn Ala  Asp Ser Pro 
    1085                 1090                 1095             


Lys Asp  Pro Val Leu Pro Met  Lys Phe Phe Thr Gln  Pro Glu Lys 
    1100                 1105                 1110             


Asp Phe  Cys Asn Asp Lys Ser  Tyr Ile Ser Glu Glu  Thr Arg Val 
    1115                 1120                 1125             


Leu Leu  Leu Thr Gly Lys Pro  Lys Pro Ala Gly Val  Leu Gly Ala 
    1130                 1135                 1140             


Val Asn  Lys Pro Leu Ser Ala  Thr Gly Arg Lys Pro  Tyr Val Arg 
    1145                 1150                 1155             


Ser Thr  Gly Thr Glu Thr Gly  Ser Asn Ile Asn Val  Asn Ser Glu 
    1160                 1165                 1170             


Leu Asn  Pro Ser Thr Gly Asn  Arg Ser Arg Glu Gln  Ser Ser Glu 
    1175                 1180                 1185             


Ala Ala  Glu Thr Gly Val Ser  Glu Asn Glu Glu Asn  Pro Val Arg 
    1190                 1195                 1200             


Ile Ile  Ser Val Thr Pro Val  Lys Asn Ile Asp Pro  Val Lys Asn 
    1205                 1210                 1215             


Lys Glu  Ile Asn Ser Asp Gln  Ala Thr Gln Gly Asn  Ile Ser Ser 
    1220                 1225                 1230             


Asp Arg  Gly Lys Lys Arg Thr  Val Thr Ala Ala Gly  Ala Glu Asn 
    1235                 1240                 1245             


Ile Gln  Gln Lys Thr Asp Glu  Lys Val Asp Glu Ser  Gly Pro Pro 
    1250                 1255                 1260             


Ala Pro  Ser Lys Pro Arg Arg  Gly Arg Arg Pro Lys  Ser Glu Ser 
    1265                 1270                 1275             


Gln Gly  Asn Ala Thr Lys Asn  Asp Asp Leu Asn Lys  Pro Ile Asn 
    1280                 1285                 1290             


Lys Gly  Arg Lys Arg Ala Ala  Val Gly Gln Glu Ser  Pro Gly Gly 
    1295                 1300                 1305             


Leu Glu  Ala Gly Asn Ala Lys  Ala Pro Lys Leu Gln  Asp Leu Ala 
    1310                 1315                 1320             


Lys Lys  Ala Ala Pro Ala Glu  Arg Gln Ile Asp Leu  Gln Arg 
    1325                 1330                 1335         


<210>  41
<211>  4824
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (27)..(3566)
<223>  

<400>  41
ggcacgaggc tcgccgcgga ctcaag atg gcg gcg tgt gga cgt gta cgg agg      53
                             Met Ala Ala Cys Gly Arg Val Arg Arg        
                             1               5                          

atg ttc cgc ttg tcg gcg gcg ctg cat ctg ctg ctg cta ttc gcg gcc      101
Met Phe Arg Leu Ser Ala Ala Leu His Leu Leu Leu Leu Phe Ala Ala         
10                  15                  20                  25          

ggg gcc gag aaa ctc ccc ggc cag ggc gtc cac agc cag ggc cag ggt      149
Gly Ala Glu Lys Leu Pro Gly Gln Gly Val His Ser Gln Gly Gln Gly         
                30                  35                  40              

ccc ggg gcc aac ttt gtg tcc ttc gta ggg cag gcc gga ggc ggc ggc      197
Pro Gly Ala Asn Phe Val Ser Phe Val Gly Gln Ala Gly Gly Gly Gly         
            45                  50                  55                  

ccg gcg ggt cag cag ctg ccc cag ctg cct cag tca tcg cag ctt cag      245
Pro Ala Gly Gln Gln Leu Pro Gln Leu Pro Gln Ser Ser Gln Leu Gln         
        60                  65                  70                      

cag caa cag cag cag cag caa cag caa cag cag cct cag ccg ccg cag      293
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gln Pro Pro Gln         
    75                  80                  85                          

ccg cct ttc ccg gcg ggt ggg cct ccg gcc cgg cgg gga gga gcg ggg      341
Pro Pro Phe Pro Ala Gly Gly Pro Pro Ala Arg Arg Gly Gly Ala Gly         
90                  95                  100                 105         

gct ggt ggg ggc tgg aag ctg gcg gag gaa gag tcc tgc agg gag gac      389
Ala Gly Gly Gly Trp Lys Leu Ala Glu Glu Glu Ser Cys Arg Glu Asp         
                110                 115                 120             

gtg acc cgc gtg tgc cct aag cac acc tgg agc aac aac ctg gcg gtg      437
Val Thr Arg Val Cys Pro Lys His Thr Trp Ser Asn Asn Leu Ala Val         
            125                 130                 135                 

ctc gag tgc ctg cag gat gtg agg gag cct gaa aat gaa att tct tca      485
Leu Glu Cys Leu Gln Asp Val Arg Glu Pro Glu Asn Glu Ile Ser Ser         
        140                 145                 150                     

gac tgc aat cat ttg ttg tgg aat tat aag ctg aac cta act aca gat      533
Asp Cys Asn His Leu Leu Trp Asn Tyr Lys Leu Asn Leu Thr Thr Asp         
    155                 160                 165                         

ccc aaa ttt gaa tct gtg gcc aga gag gtt tgc aaa tct act ata aca      581
Pro Lys Phe Glu Ser Val Ala Arg Glu Val Cys Lys Ser Thr Ile Thr         
170                 175                 180                 185         

gag att aaa gaa tgt gct gat gaa ccg gtt gga aaa ggt tac atg gtt      629
Glu Ile Lys Glu Cys Ala Asp Glu Pro Val Gly Lys Gly Tyr Met Val         
                190                 195                 200             

tcc tgc tta gtg gat cac cga ggc aac atc act gag tat cag tgt cac      677
Ser Cys Leu Val Asp His Arg Gly Asn Ile Thr Glu Tyr Gln Cys His         
            205                 210                 215                 

cag tac att acc aag atg acg ggc atc att ttt agt gat tac cgt tta      725
Gln Tyr Ile Thr Lys Met Thr Gly Ile Ile Phe Ser Asp Tyr Arg Leu         
        220                 225                 230                     

atc tgt ggc ttc atg gat gac tgc aaa aat gac atc aac att ctg aaa      773
Ile Cys Gly Phe Met Asp Asp Cys Lys Asn Asp Ile Asn Ile Leu Lys         
    235                 240                 245                         

tgt ggc agt att cgg ctt gga gaa aag gat gca cat tca caa ggt gag      821
Cys Gly Ser Ile Arg Leu Gly Glu Lys Asp Ala His Ser Gln Gly Glu         
250                 255                 260                 265         

gtg gta tca tgc ttg gag aaa ggc ctg gtg aaa gaa gca gaa gaa aga      869
Val Val Ser Cys Leu Glu Lys Gly Leu Val Lys Glu Ala Glu Glu Arg         
                270                 275                 280             

gaa ccc aag att caa gtt tct gaa ctc tgc aag aaa gcc att ctc cgg      917
Glu Pro Lys Ile Gln Val Ser Glu Leu Cys Lys Lys Ala Ile Leu Arg         
            285                 290                 295                 

gtg gct gag ctg tca tcg gat gac ttt cac tta gac cgg cat tta tat      965
Val Ala Glu Leu Ser Ser Asp Asp Phe His Leu Asp Arg His Leu Tyr         
        300                 305                 310                     

ttt gct tgc cga gat gat cgg gag cgt ttt tgt gaa aat aca caa gct     1013
Phe Ala Cys Arg Asp Asp Arg Glu Arg Phe Cys Glu Asn Thr Gln Ala         
    315                 320                 325                         

ggt gag ggc aga gtg tat aag tgc ctc ttt aac cat aaa ttt gaa gaa     1061
Gly Glu Gly Arg Val Tyr Lys Cys Leu Phe Asn His Lys Phe Glu Glu         
330                 335                 340                 345         

tcc atg agt gaa aag tgt cga gaa gca ctt aca acc cgc caa aag ctg     1109
Ser Met Ser Glu Lys Cys Arg Glu Ala Leu Thr Thr Arg Gln Lys Leu         
                350                 355                 360             

att gcc cag gat tat aaa gtc agt tat tca ttg gcc aaa tcc tgt aaa     1157
Ile Ala Gln Asp Tyr Lys Val Ser Tyr Ser Leu Ala Lys Ser Cys Lys         
            365                 370                 375                 

agt gac ttg aag aaa tac cgg tgc aat gtg gaa aac ctt ccg cga tcg     1205
Ser Asp Leu Lys Lys Tyr Arg Cys Asn Val Glu Asn Leu Pro Arg Ser         
        380                 385                 390                     

cgt gaa gcc agg ctc tcc tac ttg tta atg tgc ctg gag tca gct gta     1253
Arg Glu Ala Arg Leu Ser Tyr Leu Leu Met Cys Leu Glu Ser Ala Val         
    395                 400                 405                         

cac aga ggg cga caa gtc agc agt gag tgc cag ggg gag atg ctg gat     1301
His Arg Gly Arg Gln Val Ser Ser Glu Cys Gln Gly Glu Met Leu Asp         
410                 415                 420                 425         

tac cga cgc atg ttg atg gaa gac ttt tct ctg agc cct gag atc atc     1349
Tyr Arg Arg Met Leu Met Glu Asp Phe Ser Leu Ser Pro Glu Ile Ile         
                430                 435                 440             

cta agc tgt cgg ggg gag att gaa cac cat tgt tcc gga tta cat cga     1397
Leu Ser Cys Arg Gly Glu Ile Glu His His Cys Ser Gly Leu His Arg         
            445                 450                 455                 

aaa ggg cgg acc cta cac tgt ctg atg aaa gta gtt cga ggg gag aag     1445
Lys Gly Arg Thr Leu His Cys Leu Met Lys Val Val Arg Gly Glu Lys         
        460                 465                 470                     

ggg aac ctt gga atg aac tgc cag cag gcg ctt caa aca ctg att cag     1493
Gly Asn Leu Gly Met Asn Cys Gln Gln Ala Leu Gln Thr Leu Ile Gln         
    475                 480                 485                         

gag act gac cct ggt gca gat tac cgc att gat cga gct ttg aat gaa     1541
Glu Thr Asp Pro Gly Ala Asp Tyr Arg Ile Asp Arg Ala Leu Asn Glu         
490                 495                 500                 505         

gct tgt gaa tct gta atc cag aca gcc tgc aaa cat ata aga tct gga     1589
Ala Cys Glu Ser Val Ile Gln Thr Ala Cys Lys His Ile Arg Ser Gly         
                510                 515                 520             

gac cca atg atc ttg tcg tgc ctg atg gaa cat tta tac aca gag aag     1637
Asp Pro Met Ile Leu Ser Cys Leu Met Glu His Leu Tyr Thr Glu Lys         
            525                 530                 535                 

atg gta gaa gac tgt gaa cac cgt ctc tta gag ctg cag tat ttc atc     1685
Met Val Glu Asp Cys Glu His Arg Leu Leu Glu Leu Gln Tyr Phe Ile         
        540                 545                 550                     

tcc cgg gat tgg aag ctg gac cct gtc ctg tac cgc aag tgc cag gga     1733
Ser Arg Asp Trp Lys Leu Asp Pro Val Leu Tyr Arg Lys Cys Gln Gly         
    555                 560                 565                         

gac gct tct cgt ctt tgc cac acc cac ggt tgg aat gag acc agt gaa     1781
Asp Ala Ser Arg Leu Cys His Thr His Gly Trp Asn Glu Thr Ser Glu         
570                 575                 580                 585         

ttt atg cct cag gga gct gtg ttc tct tgt tta tac aga cac gcc tac     1829
Phe Met Pro Gln Gly Ala Val Phe Ser Cys Leu Tyr Arg His Ala Tyr         
                590                 595                 600             

cgc act gag gaa cag gga agg agg ctc tca cgg gag tgc cga gct gaa     1877
Arg Thr Glu Glu Gln Gly Arg Arg Leu Ser Arg Glu Cys Arg Ala Glu         
            605                 610                 615                 

gtc caa agg atc cta cac cag cgt gcc atg gat gtc aag ctg gat cct     1925
Val Gln Arg Ile Leu His Gln Arg Ala Met Asp Val Lys Leu Asp Pro         
        620                 625                 630                     

gcc ctc cag gat aag tgc ctg att gat ctg gga aaa tgg tgc agt gag     1973
Ala Leu Gln Asp Lys Cys Leu Ile Asp Leu Gly Lys Trp Cys Ser Glu         
    635                 640                 645                         

aaa aca gag act gga cag gag ctg gag tgc ctt cag gac cat ctg gat     2021
Lys Thr Glu Thr Gly Gln Glu Leu Glu Cys Leu Gln Asp His Leu Asp         
650                 655                 660                 665         

gac ttg gtg gtg gag tgt aga gat ata gtt ggc aac ctc act gag tta     2069
Asp Leu Val Val Glu Cys Arg Asp Ile Val Gly Asn Leu Thr Glu Leu         
                670                 675                 680             

gaa tca gag gat att caa ata gaa gcc ttg ctg atg aga gcc tgt gag     2117
Glu Ser Glu Asp Ile Gln Ile Glu Ala Leu Leu Met Arg Ala Cys Glu         
            685                 690                 695                 

ccc ata att cag aac ttc tgc cac gat gtg gca gat aac cag ata gac     2165
Pro Ile Ile Gln Asn Phe Cys His Asp Val Ala Asp Asn Gln Ile Asp         
        700                 705                 710                     

tct ggg gac ctg atg gag tgt ctg ata cag aac aaa cac cag aag gac     2213
Ser Gly Asp Leu Met Glu Cys Leu Ile Gln Asn Lys His Gln Lys Asp         
    715                 720                 725                         

atg aac gag aag tgt gcc atc gga gtt acc cac ttc cag ctg gtg cag     2261
Met Asn Glu Lys Cys Ala Ile Gly Val Thr His Phe Gln Leu Val Gln         
730                 735                 740                 745         

atg aag gat ttt cgg ttt tct tac aag ttt aaa atg gcc tgc aag gag     2309
Met Lys Asp Phe Arg Phe Ser Tyr Lys Phe Lys Met Ala Cys Lys Glu         
                750                 755                 760             

gac gtg ttg aag ctt tgc cca aac ata aaa aag aag gtg gac gtg gtg     2357
Asp Val Leu Lys Leu Cys Pro Asn Ile Lys Lys Lys Val Asp Val Val         
            765                 770                 775                 

atc tgc ctg agc acg acc gtg cgc aat gac act ctg cag gaa gcc aag     2405
Ile Cys Leu Ser Thr Thr Val Arg Asn Asp Thr Leu Gln Glu Ala Lys         
        780                 785                 790                     

gag cac agg gtg tcc ctg aag tgc cgc agg cag ctc cgt gtg gag gag     2453
Glu His Arg Val Ser Leu Lys Cys Arg Arg Gln Leu Arg Val Glu Glu         
    795                 800                 805                         

ctg gag atg acg gag gac atc cgc ttg gag cca gat cta tac gaa gcc     2501
Leu Glu Met Thr Glu Asp Ile Arg Leu Glu Pro Asp Leu Tyr Glu Ala         
810                 815                 820                 825         

tgc aag agt gac atc aaa aac ttc tgt tcc gct gtg caa tat ggc aac     2549
Cys Lys Ser Asp Ile Lys Asn Phe Cys Ser Ala Val Gln Tyr Gly Asn         
                830                 835                 840             

gct cag att atc gaa tgt ctg aaa gaa aac aag aag cag cta agc acc     2597
Ala Gln Ile Ile Glu Cys Leu Lys Glu Asn Lys Lys Gln Leu Ser Thr         
            845                 850                 855                 

cgc tgc cac caa aaa gta ttt aag ctg cag gag aca gag atg atg gac     2645
Arg Cys His Gln Lys Val Phe Lys Leu Gln Glu Thr Glu Met Met Asp         
        860                 865                 870                     

cca gag cta gac tac acc ctc atg agg gtc tgc aag cag atg ata aag     2693
Pro Glu Leu Asp Tyr Thr Leu Met Arg Val Cys Lys Gln Met Ile Lys         
    875                 880                 885                         

agg ttc tgt ccg gaa gca gat tct aaa acc atg ttg cag tgc ttg aag     2741
Arg Phe Cys Pro Glu Ala Asp Ser Lys Thr Met Leu Gln Cys Leu Lys         
890                 895                 900                 905         

caa aat aaa aac agt gaa ttg atg gat ccc aaa tgc aaa cag atg ata     2789
Gln Asn Lys Asn Ser Glu Leu Met Asp Pro Lys Cys Lys Gln Met Ile         
                910                 915                 920             

acc aag cgc cag atc acc cag aac aca gat tac cgc tta aac ccc atg     2837
Thr Lys Arg Gln Ile Thr Gln Asn Thr Asp Tyr Arg Leu Asn Pro Met         
            925                 930                 935                 

tta aga aaa gcc tgt aaa gct gac att cct aaa ttc tgt cac ggt atc     2885
Leu Arg Lys Ala Cys Lys Ala Asp Ile Pro Lys Phe Cys His Gly Ile         
        940                 945                 950                     

ctg act aag gcc aag gat gat tca gaa tta gaa gga caa gtc atc tct     2933
Leu Thr Lys Ala Lys Asp Asp Ser Glu Leu Glu Gly Gln Val Ile Ser         
    955                 960                 965                         

tgc ctg aag ctg aga tat gct gac cag cgc ctg tct tca gac tgt gaa     2981
Cys Leu Lys Leu Arg Tyr Ala Asp Gln Arg Leu Ser Ser Asp Cys Glu         
970                 975                 980                 985         

gac cag atc cga atc att atc cag gag tcc gcc ctg gac tac cgc  ctg    3029
Asp Gln Ile Arg Ile Ile Ile Gln Glu Ser Ala Leu Asp Tyr Arg  Leu        
                990                 995                 1000            

gat cct cag ctc  cag ctg cac tgc tca  gac gag atc tcc agt  cta      3074
Asp Pro Gln Leu  Gln Leu His Cys Ser  Asp Glu Ile Ser Ser  Leu          
            1005                 1010                 1015              

tgt gct gaa gaa  gca gca gcc caa gag  cag aca ggt cag gtg  gag      3119
Cys Ala Glu Glu  Ala Ala Ala Gln Glu  Gln Thr Gly Gln Val  Glu          
            1020                 1025                 1030              

gag tgc ctc aag  gtc aac ctg ctc aag  atc aaa aca gaa ttg  tgt      3164
Glu Cys Leu Lys  Val Asn Leu Leu Lys  Ile Lys Thr Glu Leu  Cys          
            1035                 1040                 1045              

aaa aag gaa gtg  cta aac atg ctg aag  gaa agc aaa gca gac  atc      3209
Lys Lys Glu Val  Leu Asn Met Leu Lys  Glu Ser Lys Ala Asp  Ile          
            1050                 1055                 1060              

ttt gtt gac ccg  gta ctt cat act gct  tgt gcc ctg gac att  aaa      3254
Phe Val Asp Pro  Val Leu His Thr Ala  Cys Ala Leu Asp Ile  Lys          
            1065                 1070                 1075              

cac cac tgc gca  gcc atc acc cct ggc  cgc ggg cgt caa atg  tcc      3299
His His Cys Ala  Ala Ile Thr Pro Gly  Arg Gly Arg Gln Met  Ser          
            1080                 1085                 1090              

tgt ctc atg gaa  gca ctg gag gat aag  cgg gtg agg tta cag  ccc      3344
Cys Leu Met Glu  Ala Leu Glu Asp Lys  Arg Val Arg Leu Gln  Pro          
            1095                 1100                 1105              

gag tgc aaa aag  cgc ctc aat gac cgg  att gag atg tgg agt  tac      3389
Glu Cys Lys Lys  Arg Leu Asn Asp Arg  Ile Glu Met Trp Ser  Tyr          
            1110                 1115                 1120              

gca gca aag gtg  gcc cca gca gat ggc  ttc tct gat ctt gcc  atg      3434
Ala Ala Lys Val  Ala Pro Ala Asp Gly  Phe Ser Asp Leu Ala  Met          
            1125                 1130                 1135              

caa gta atg acg  tct cca tct aag aac  tac att ctc tct gtg  atc      3479
Gln Val Met Thr  Ser Pro Ser Lys Asn  Tyr Ile Leu Ser Val  Ile          
            1140                 1145                 1150              

agt ggg agc atc  tgt ata ttg ttc ctg  att ggc ctg atg tgt  gga      3524
Ser Gly Ser Ile  Cys Ile Leu Phe Leu  Ile Gly Leu Met Cys  Gly          
            1155                 1160                 1165              

cgg atc acc aag  cga gtg aca cga gag  ctc aag gac agg tag           3566
Arg Ile Thr Lys  Arg Val Thr Arg Glu  Leu Lys Asp Arg                   
            1170                 1175                                   

agccaccttg accaccaaag gaactaccta tccagtgccc agtttgtaca gccctcttgt   3626

atagcatccc cactcacctc gctcttctca gaagtgacac caaccccgtg ttagagcatt   3686

agcagatgtc cactgcgttg tcccatccag cctccactcg tgtccatggt gtcctcctcc   3746

tcctcaccgt gcagcagcag cagctggtcg ctggggttac tgcctttgtt tggcaaactt   3806

gggtttacct gcctgtagac aagtctctct cataccaaca gaacttccgg tacttccaga   3866

accaactcac ctgacctgca actcaaaggc ttttttaaga aaaccaccaa aaaaaaaaat   3926

ttttttaaag aaaaaaatgt atatagtaac gcatctcctc caggcttgat ttgggcaatg   3986

gggttatgtc tttcatatga ctgtgtaaaa caaagacagg acttggaggg gaagcacacc   4046

acccagtgtg ccatgactga ggtgtctcgt tcatctctca gaagcacctt ggggcctcgc   4106

cagggccgtg gtcttcaccg aggcgtgggt gggcagccgt tccccaggct gtgtggggtc   4166

ctgctttctt ctgctgagac agtgacgctt tccagtttcc accctaatca gccactgctg   4226

gtcacagccc cacagccatg ggtatttctg tggtctcctc gcttcattga agcaaagcat   4286

gagccttcct agacaagggc agctggggag gggaagggac cggaagtttg tgaagttgaa   4346

cagtccatcc atctgcactg agaggctgga tcctgagtcc cggggcagca ggatcccagg   4406

aaccttcctc ctccagggca gcacaggact cagccatgtc tggaccggcc ctgctgaggc   4466

tacagtcact ctggaagctc tgcgcttcat caggaggcag gactgtggcg ggaggggtcc   4526

ttgaagatgg gtgtggggag cagtgggtca ggaagtggga gccagaggtt tgactcactt   4586

tgctttattt ttcaggctac aatacaggtc agagacaatg gcttataaag gtttagtgtg   4646

gtctcaggat gtgacaggca gtccagcctg acctttctgc acactccaga caaacttccc   4706

agacaagctc ctttgtgcct ctacgtggag agggtgtgga aagttatcac attaaaagat   4766

ggaggatttg ctctgttaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa     4824


<210>  42
<211>  1179
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Ala Cys Gly Arg Val Arg Arg Met Phe Arg Leu Ser Ala Ala 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Phe Ala Ala Gly Ala Glu Lys Leu Pro Gly 
            20                  25                  30          


Gln Gly Val His Ser Gln Gly Gln Gly Pro Gly Ala Asn Phe Val Ser 
        35                  40                  45              


Phe Val Gly Gln Ala Gly Gly Gly Gly Pro Ala Gly Gln Gln Leu Pro 
    50                  55                  60                  


Gln Leu Pro Gln Ser Ser Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Pro Gln Pro Pro Gln Pro Pro Phe Pro Ala Gly Gly 
                85                  90                  95      


Pro Pro Ala Arg Arg Gly Gly Ala Gly Ala Gly Gly Gly Trp Lys Leu 
            100                 105                 110         


Ala Glu Glu Glu Ser Cys Arg Glu Asp Val Thr Arg Val Cys Pro Lys 
        115                 120                 125             


His Thr Trp Ser Asn Asn Leu Ala Val Leu Glu Cys Leu Gln Asp Val 
    130                 135                 140                 


Arg Glu Pro Glu Asn Glu Ile Ser Ser Asp Cys Asn His Leu Leu Trp 
145                 150                 155                 160 


Asn Tyr Lys Leu Asn Leu Thr Thr Asp Pro Lys Phe Glu Ser Val Ala 
                165                 170                 175     


Arg Glu Val Cys Lys Ser Thr Ile Thr Glu Ile Lys Glu Cys Ala Asp 
            180                 185                 190         


Glu Pro Val Gly Lys Gly Tyr Met Val Ser Cys Leu Val Asp His Arg 
        195                 200                 205             


Gly Asn Ile Thr Glu Tyr Gln Cys His Gln Tyr Ile Thr Lys Met Thr 
    210                 215                 220                 


Gly Ile Ile Phe Ser Asp Tyr Arg Leu Ile Cys Gly Phe Met Asp Asp 
225                 230                 235                 240 


Cys Lys Asn Asp Ile Asn Ile Leu Lys Cys Gly Ser Ile Arg Leu Gly 
                245                 250                 255     


Glu Lys Asp Ala His Ser Gln Gly Glu Val Val Ser Cys Leu Glu Lys 
            260                 265                 270         


Gly Leu Val Lys Glu Ala Glu Glu Arg Glu Pro Lys Ile Gln Val Ser 
        275                 280                 285             


Glu Leu Cys Lys Lys Ala Ile Leu Arg Val Ala Glu Leu Ser Ser Asp 
    290                 295                 300                 


Asp Phe His Leu Asp Arg His Leu Tyr Phe Ala Cys Arg Asp Asp Arg 
305                 310                 315                 320 


Glu Arg Phe Cys Glu Asn Thr Gln Ala Gly Glu Gly Arg Val Tyr Lys 
                325                 330                 335     


Cys Leu Phe Asn His Lys Phe Glu Glu Ser Met Ser Glu Lys Cys Arg 
            340                 345                 350         


Glu Ala Leu Thr Thr Arg Gln Lys Leu Ile Ala Gln Asp Tyr Lys Val 
        355                 360                 365             


Ser Tyr Ser Leu Ala Lys Ser Cys Lys Ser Asp Leu Lys Lys Tyr Arg 
    370                 375                 380                 


Cys Asn Val Glu Asn Leu Pro Arg Ser Arg Glu Ala Arg Leu Ser Tyr 
385                 390                 395                 400 


Leu Leu Met Cys Leu Glu Ser Ala Val His Arg Gly Arg Gln Val Ser 
                405                 410                 415     


Ser Glu Cys Gln Gly Glu Met Leu Asp Tyr Arg Arg Met Leu Met Glu 
            420                 425                 430         


Asp Phe Ser Leu Ser Pro Glu Ile Ile Leu Ser Cys Arg Gly Glu Ile 
        435                 440                 445             


Glu His His Cys Ser Gly Leu His Arg Lys Gly Arg Thr Leu His Cys 
    450                 455                 460                 


Leu Met Lys Val Val Arg Gly Glu Lys Gly Asn Leu Gly Met Asn Cys 
465                 470                 475                 480 


Gln Gln Ala Leu Gln Thr Leu Ile Gln Glu Thr Asp Pro Gly Ala Asp 
                485                 490                 495     


Tyr Arg Ile Asp Arg Ala Leu Asn Glu Ala Cys Glu Ser Val Ile Gln 
            500                 505                 510         


Thr Ala Cys Lys His Ile Arg Ser Gly Asp Pro Met Ile Leu Ser Cys 
        515                 520                 525             


Leu Met Glu His Leu Tyr Thr Glu Lys Met Val Glu Asp Cys Glu His 
    530                 535                 540                 


Arg Leu Leu Glu Leu Gln Tyr Phe Ile Ser Arg Asp Trp Lys Leu Asp 
545                 550                 555                 560 


Pro Val Leu Tyr Arg Lys Cys Gln Gly Asp Ala Ser Arg Leu Cys His 
                565                 570                 575     


Thr His Gly Trp Asn Glu Thr Ser Glu Phe Met Pro Gln Gly Ala Val 
            580                 585                 590         


Phe Ser Cys Leu Tyr Arg His Ala Tyr Arg Thr Glu Glu Gln Gly Arg 
        595                 600                 605             


Arg Leu Ser Arg Glu Cys Arg Ala Glu Val Gln Arg Ile Leu His Gln 
    610                 615                 620                 


Arg Ala Met Asp Val Lys Leu Asp Pro Ala Leu Gln Asp Lys Cys Leu 
625                 630                 635                 640 


Ile Asp Leu Gly Lys Trp Cys Ser Glu Lys Thr Glu Thr Gly Gln Glu 
                645                 650                 655     


Leu Glu Cys Leu Gln Asp His Leu Asp Asp Leu Val Val Glu Cys Arg 
            660                 665                 670         


Asp Ile Val Gly Asn Leu Thr Glu Leu Glu Ser Glu Asp Ile Gln Ile 
        675                 680                 685             


Glu Ala Leu Leu Met Arg Ala Cys Glu Pro Ile Ile Gln Asn Phe Cys 
    690                 695                 700                 


His Asp Val Ala Asp Asn Gln Ile Asp Ser Gly Asp Leu Met Glu Cys 
705                 710                 715                 720 


Leu Ile Gln Asn Lys His Gln Lys Asp Met Asn Glu Lys Cys Ala Ile 
                725                 730                 735     


Gly Val Thr His Phe Gln Leu Val Gln Met Lys Asp Phe Arg Phe Ser 
            740                 745                 750         


Tyr Lys Phe Lys Met Ala Cys Lys Glu Asp Val Leu Lys Leu Cys Pro 
        755                 760                 765             


Asn Ile Lys Lys Lys Val Asp Val Val Ile Cys Leu Ser Thr Thr Val 
    770                 775                 780                 


Arg Asn Asp Thr Leu Gln Glu Ala Lys Glu His Arg Val Ser Leu Lys 
785                 790                 795                 800 


Cys Arg Arg Gln Leu Arg Val Glu Glu Leu Glu Met Thr Glu Asp Ile 
                805                 810                 815     


Arg Leu Glu Pro Asp Leu Tyr Glu Ala Cys Lys Ser Asp Ile Lys Asn 
            820                 825                 830         


Phe Cys Ser Ala Val Gln Tyr Gly Asn Ala Gln Ile Ile Glu Cys Leu 
        835                 840                 845             


Lys Glu Asn Lys Lys Gln Leu Ser Thr Arg Cys His Gln Lys Val Phe 
    850                 855                 860                 


Lys Leu Gln Glu Thr Glu Met Met Asp Pro Glu Leu Asp Tyr Thr Leu 
865                 870                 875                 880 


Met Arg Val Cys Lys Gln Met Ile Lys Arg Phe Cys Pro Glu Ala Asp 
                885                 890                 895     


Ser Lys Thr Met Leu Gln Cys Leu Lys Gln Asn Lys Asn Ser Glu Leu 
            900                 905                 910         


Met Asp Pro Lys Cys Lys Gln Met Ile Thr Lys Arg Gln Ile Thr Gln 
        915                 920                 925             


Asn Thr Asp Tyr Arg Leu Asn Pro Met Leu Arg Lys Ala Cys Lys Ala 
    930                 935                 940                 


Asp Ile Pro Lys Phe Cys His Gly Ile Leu Thr Lys Ala Lys Asp Asp 
945                 950                 955                 960 


Ser Glu Leu Glu Gly Gln Val Ile Ser Cys Leu Lys Leu Arg Tyr Ala 
                965                 970                 975     


Asp Gln Arg Leu Ser Ser Asp Cys Glu Asp Gln Ile Arg Ile Ile Ile 
            980                 985                 990         


Gln Glu Ser Ala Leu Asp Tyr Arg  Leu Asp Pro Gln Leu  Gln Leu His 
        995                 1000                 1005             


Cys Ser  Asp Glu Ile Ser Ser  Leu Cys Ala Glu Glu  Ala Ala Ala 
    1010                 1015                 1020             


Gln Glu  Gln Thr Gly Gln Val  Glu Glu Cys Leu Lys  Val Asn Leu 
    1025                 1030                 1035             


Leu Lys  Ile Lys Thr Glu Leu  Cys Lys Lys Glu Val  Leu Asn Met 
    1040                 1045                 1050             


Leu Lys  Glu Ser Lys Ala Asp  Ile Phe Val Asp Pro  Val Leu His 
    1055                 1060                 1065             


Thr Ala  Cys Ala Leu Asp Ile  Lys His His Cys Ala  Ala Ile Thr 
    1070                 1075                 1080             


Pro Gly  Arg Gly Arg Gln Met  Ser Cys Leu Met Glu  Ala Leu Glu 
    1085                 1090                 1095             


Asp Lys  Arg Val Arg Leu Gln  Pro Glu Cys Lys Lys  Arg Leu Asn 
    1100                 1105                 1110             


Asp Arg  Ile Glu Met Trp Ser  Tyr Ala Ala Lys Val  Ala Pro Ala 
    1115                 1120                 1125             


Asp Gly  Phe Ser Asp Leu Ala  Met Gln Val Met Thr  Ser Pro Ser 
    1130                 1135                 1140             


Lys Asn  Tyr Ile Leu Ser Val  Ile Ser Gly Ser Ile  Cys Ile Leu 
    1145                 1150                 1155             


Phe Leu  Ile Gly Leu Met Cys  Gly Arg Ile Thr Lys  Arg Val Thr 
    1160                 1165                 1170             


Arg Glu  Leu Lys Asp Arg 
    1175                 


<210>  43
<211>  1760
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (14)..(1645)
<223>  

<400>  43
ccttccggtc acc atg gcg acc agg cgc ctt ggg gtc ggg gag acg ctg        49
               Met Ala Thr Arg Arg Leu Gly Val Gly Glu Thr Leu          
               1               5                   10                   

ggg gcc ctc aac gcg gcc ctg ggg cca ggc ggt ccg gtg tgg atc aag       97
Gly Ala Leu Asn Ala Ala Leu Gly Pro Gly Gly Pro Val Trp Ile Lys         
        15                  20                  25                      

gag acg cgc acc cgc cac ctg cgt tcc cga gac ttt ctg gca ccg cac      145
Glu Thr Arg Thr Arg His Leu Arg Ser Arg Asp Phe Leu Ala Pro His         
    30                  35                  40                          

cgc gcg ctg cag gcg cgc ttc gat gac ggc cag gtt ccg gag cat ttg      193
Arg Ala Leu Gln Ala Arg Phe Asp Asp Gly Gln Val Pro Glu His Leu         
45                  50                  55                  60          

ctc cat gcc ctc gcc tgc ctg cag ggc ccc ggt gtg gcc ccg gtg ctg      241
Leu His Ala Leu Ala Cys Leu Gln Gly Pro Gly Val Ala Pro Val Leu         
                65                  70                  75              

cgc tgc gcg ccg acc ccc gcg ggt ctg tct ctc caa ctg cag cgg tcc      289
Arg Cys Ala Pro Thr Pro Ala Gly Leu Ser Leu Gln Leu Gln Arg Ser         
            80                  85                  90                  

gcc gtc ttc gag cgc gtc ctc agc gcc gtg gcc gcc tat gcc acg ccc      337
Ala Val Phe Glu Arg Val Leu Ser Ala Val Ala Ala Tyr Ala Thr Pro         
        95                  100                 105                     

gcc tcg cct gcc tcg ctg ggc cag cgc gtc tta cta cac tgc cca gca      385
Ala Ser Pro Ala Ser Leu Gly Gln Arg Val Leu Leu His Cys Pro Ala         
    110                 115                 120                         

ctg cgc agc tcc ccc tgc gca ctc cgc ttg agc cag ctg cgt acg gtg      433
Leu Arg Ser Ser Pro Cys Ala Leu Arg Leu Ser Gln Leu Arg Thr Val         
125                 130                 135                 140         

ctc gtg gcc gat cac ctg gcg cga gcc ctg cgc gct cac ggg gtg tgc      481
Leu Val Ala Asp His Leu Ala Arg Ala Leu Arg Ala His Gly Val Cys         
                145                 150                 155             

gtg cgc cta gtg cca gct gtg cgg gat ccg cac atg ctg acc ttc ctg      529
Val Arg Leu Val Pro Ala Val Arg Asp Pro His Met Leu Thr Phe Leu         
            160                 165                 170                 

cag caa ctg cgg gtg gac tgg ccc gct gcc tcg gag aga gct tcc tcc      577
Gln Gln Leu Arg Val Asp Trp Pro Ala Ala Ser Glu Arg Ala Ser Ser         
        175                 180                 185                     

cac acc ctg agg agc cac gcc ctt gaa gaa ctt acc tct gct aat gac      625
His Thr Leu Arg Ser His Ala Leu Glu Glu Leu Thr Ser Ala Asn Asp         
    190                 195                 200                         

ggg agg aca ctg tcc cct ggc atc cta ggc aga ctg tgt ctg aag gag      673
Gly Arg Thr Leu Ser Pro Gly Ile Leu Gly Arg Leu Cys Leu Lys Glu         
205                 210                 215                 220         

ctg gtg gaa gaa cag ggc cgc aca gct ggc tat gac ccc aac ctg gac      721
Leu Val Glu Glu Gln Gly Arg Thr Ala Gly Tyr Asp Pro Asn Leu Asp         
                225                 230                 235             

aac tgt ctg gtg act gag gat ctc ctc tct gtg ctg gct gag ctg caa      769
Asn Cys Leu Val Thr Glu Asp Leu Leu Ser Val Leu Ala Glu Leu Gln         
            240                 245                 250                 

gag gct cta tgg cat tgg ccc gag gac agc cac cca ggc ctg gct ggg      817
Glu Ala Leu Trp His Trp Pro Glu Asp Ser His Pro Gly Leu Ala Gly         
        255                 260                 265                     

gcc tca gat act ggt aca ggc ggc tgc ctg gtt gta cat gtt gtt agc      865
Ala Ser Asp Thr Gly Thr Gly Gly Cys Leu Val Val His Val Val Ser         
    270                 275                 280                         

tgt gag gag gag ttc cag caa cag aag ttg gac ctg ctt tgg cgg aag      913
Cys Glu Glu Glu Phe Gln Gln Gln Lys Leu Asp Leu Leu Trp Arg Lys         
285                 290                 295                 300         

ttg gtt gac aag gct cca ctc aga cag aag cac ctc atc tgt ggc cct      961
Leu Val Asp Lys Ala Pro Leu Arg Gln Lys His Leu Ile Cys Gly Pro         
                305                 310                 315             

gtg aaa gta gct ggt gca cct ggc act ctg atg act gcc cct gag tac     1009
Val Lys Val Ala Gly Ala Pro Gly Thr Leu Met Thr Ala Pro Glu Tyr         
            320                 325                 330                 

tac gag ttc cgg cat acc cag gtg tgc aag gcc tca gca ctg aag cat     1057
Tyr Glu Phe Arg His Thr Gln Val Cys Lys Ala Ser Ala Leu Lys His         
        335                 340                 345                     

ggt ggg gat ctg gca caa gac cca gcc tgg aca gag atc ttt ggt gtt     1105
Gly Gly Asp Leu Ala Gln Asp Pro Ala Trp Thr Glu Ile Phe Gly Val         
    350                 355                 360                         

ctc tct gtg gcc acc atc aag ttt gag atg ctg agc aca gcc cca cag     1153
Leu Ser Val Ala Thr Ile Lys Phe Glu Met Leu Ser Thr Ala Pro Gln         
365                 370                 375                 380         

agt cag ctc ttc ctg gct ctg gct gac agc agt atc tcc acg aag ggc     1201
Ser Gln Leu Phe Leu Ala Leu Ala Asp Ser Ser Ile Ser Thr Lys Gly         
                385                 390                 395             

aca aag agt ggc acc ttt gtc atg tat aat tgt gcc cgt ctt gcc aca     1249
Thr Lys Ser Gly Thr Phe Val Met Tyr Asn Cys Ala Arg Leu Ala Thr         
            400                 405                 410                 

ctc ttt gag agt tac aag tgt agt atg gaa caa ggt ctg tac ccc act     1297
Leu Phe Glu Ser Tyr Lys Cys Ser Met Glu Gln Gly Leu Tyr Pro Thr         
        415                 420                 425                     

ttt cct cct gtg agc agt ctg gac ttc tca ctg cta cat gat gag ggt     1345
Phe Pro Pro Val Ser Ser Leu Asp Phe Ser Leu Leu His Asp Glu Gly         
    430                 435                 440                         

gag tgg ttg ttg ctc ttc aac agt atc ctc ccc ttt ccg gat ctg ctg     1393
Glu Trp Leu Leu Leu Phe Asn Ser Ile Leu Pro Phe Pro Asp Leu Leu         
445                 450                 455                 460         

agc cgg aca gca gtg ctg gac tgc aca gcc ccg ggg ctc cac att gct     1441
Ser Arg Thr Ala Val Leu Asp Cys Thr Ala Pro Gly Leu His Ile Ala         
                465                 470                 475             

gta cgc aca gag atg ata tgc aag ttc ctg gta cag ctc agc atg gat     1489
Val Arg Thr Glu Met Ile Cys Lys Phe Leu Val Gln Leu Ser Met Asp         
            480                 485                 490                 

ttc agc tcc tac tac aac cgg gta cac atc ctg ggg gag cct cga cca     1537
Phe Ser Ser Tyr Tyr Asn Arg Val His Ile Leu Gly Glu Pro Arg Pro         
        495                 500                 505                     

cac ctc ttt ggt cag atg ttc gtc cgc ctg cag ctt ctg aga gct gtg     1585
His Leu Phe Gly Gln Met Phe Val Arg Leu Gln Leu Leu Arg Ala Val         
    510                 515                 520                         

cgt gag gtg ctc cat act ggc ctg gct atg ctg ggt ctc cct cca ctg     1633
Arg Glu Val Leu His Thr Gly Leu Ala Met Leu Gly Leu Pro Pro Leu         
525                 530                 535                 540         

agc cac att taa ggccacagag gctccaatac ctgggaatgt tcacaaagtc         1685
Ser His Ile                                                             
                                                                        

atcaactgga aaaaaagcaa aaacccacgg ccaaaataaa ttggtactgt ttgttacaaa   1745

aaaaaaaaaa aaaaa                                                    1760


<210>  44
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Thr Arg Arg Leu Gly Val Gly Glu Thr Leu Gly Ala Leu Asn 
1               5                   10                  15      


Ala Ala Leu Gly Pro Gly Gly Pro Val Trp Ile Lys Glu Thr Arg Thr 
            20                  25                  30          


Arg His Leu Arg Ser Arg Asp Phe Leu Ala Pro His Arg Ala Leu Gln 
        35                  40                  45              


Ala Arg Phe Asp Asp Gly Gln Val Pro Glu His Leu Leu His Ala Leu 
    50                  55                  60                  


Ala Cys Leu Gln Gly Pro Gly Val Ala Pro Val Leu Arg Cys Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Gly Leu Ser Leu Gln Leu Gln Arg Ser Ala Val Phe Glu 
                85                  90                  95      


Arg Val Leu Ser Ala Val Ala Ala Tyr Ala Thr Pro Ala Ser Pro Ala 
            100                 105                 110         


Ser Leu Gly Gln Arg Val Leu Leu His Cys Pro Ala Leu Arg Ser Ser 
        115                 120                 125             


Pro Cys Ala Leu Arg Leu Ser Gln Leu Arg Thr Val Leu Val Ala Asp 
    130                 135                 140                 


His Leu Ala Arg Ala Leu Arg Ala His Gly Val Cys Val Arg Leu Val 
145                 150                 155                 160 


Pro Ala Val Arg Asp Pro His Met Leu Thr Phe Leu Gln Gln Leu Arg 
                165                 170                 175     


Val Asp Trp Pro Ala Ala Ser Glu Arg Ala Ser Ser His Thr Leu Arg 
            180                 185                 190         


Ser His Ala Leu Glu Glu Leu Thr Ser Ala Asn Asp Gly Arg Thr Leu 
        195                 200                 205             


Ser Pro Gly Ile Leu Gly Arg Leu Cys Leu Lys Glu Leu Val Glu Glu 
    210                 215                 220                 


Gln Gly Arg Thr Ala Gly Tyr Asp Pro Asn Leu Asp Asn Cys Leu Val 
225                 230                 235                 240 


Thr Glu Asp Leu Leu Ser Val Leu Ala Glu Leu Gln Glu Ala Leu Trp 
                245                 250                 255     


His Trp Pro Glu Asp Ser His Pro Gly Leu Ala Gly Ala Ser Asp Thr 
            260                 265                 270         


Gly Thr Gly Gly Cys Leu Val Val His Val Val Ser Cys Glu Glu Glu 
        275                 280                 285             


Phe Gln Gln Gln Lys Leu Asp Leu Leu Trp Arg Lys Leu Val Asp Lys 
    290                 295                 300                 


Ala Pro Leu Arg Gln Lys His Leu Ile Cys Gly Pro Val Lys Val Ala 
305                 310                 315                 320 


Gly Ala Pro Gly Thr Leu Met Thr Ala Pro Glu Tyr Tyr Glu Phe Arg 
                325                 330                 335     


His Thr Gln Val Cys Lys Ala Ser Ala Leu Lys His Gly Gly Asp Leu 
            340                 345                 350         


Ala Gln Asp Pro Ala Trp Thr Glu Ile Phe Gly Val Leu Ser Val Ala 
        355                 360                 365             


Thr Ile Lys Phe Glu Met Leu Ser Thr Ala Pro Gln Ser Gln Leu Phe 
    370                 375                 380                 


Leu Ala Leu Ala Asp Ser Ser Ile Ser Thr Lys Gly Thr Lys Ser Gly 
385                 390                 395                 400 


Thr Phe Val Met Tyr Asn Cys Ala Arg Leu Ala Thr Leu Phe Glu Ser 
                405                 410                 415     


Tyr Lys Cys Ser Met Glu Gln Gly Leu Tyr Pro Thr Phe Pro Pro Val 
            420                 425                 430         


Ser Ser Leu Asp Phe Ser Leu Leu His Asp Glu Gly Glu Trp Leu Leu 
        435                 440                 445             


Leu Phe Asn Ser Ile Leu Pro Phe Pro Asp Leu Leu Ser Arg Thr Ala 
    450                 455                 460                 


Val Leu Asp Cys Thr Ala Pro Gly Leu His Ile Ala Val Arg Thr Glu 
465                 470                 475                 480 


Met Ile Cys Lys Phe Leu Val Gln Leu Ser Met Asp Phe Ser Ser Tyr 
                485                 490                 495     


Tyr Asn Arg Val His Ile Leu Gly Glu Pro Arg Pro His Leu Phe Gly 
            500                 505                 510         


Gln Met Phe Val Arg Leu Gln Leu Leu Arg Ala Val Arg Glu Val Leu 
        515                 520                 525             


His Thr Gly Leu Ala Met Leu Gly Leu Pro Pro Leu Ser His Ile 
    530                 535                 540             


<210>  45
<211>  1734
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (14)..(1564)
<223>  

<220>
<221>  misc_feature
<222>  (1547)..(1549)
<223>  Xaa=phenylalanine or serine


<400>  45
ccttccggtc acc atg gcg acc agg cgc ctt ggg gtc ggg gag acg ctg        49
               Met Ala Thr Arg Arg Leu Gly Val Gly Glu Thr Leu          
               1               5                   10                   

ggg gcc ctc aac gcg gcc ctg ggg cca ggc ggt ccg gtg tgg atc aag       97
Gly Ala Leu Asn Ala Ala Leu Gly Pro Gly Gly Pro Val Trp Ile Lys         
        15                  20                  25                      

gag acg cgc acc cgc cac ctg cgt tcc cga gac ttt ctg gca ccg cac      145
Glu Thr Arg Thr Arg His Leu Arg Ser Arg Asp Phe Leu Ala Pro His         
    30                  35                  40                          

cgc gcg ctg cag gcg cgc ttc gat gac ggc cag gtt ccg gag cat ttg      193
Arg Ala Leu Gln Ala Arg Phe Asp Asp Gly Gln Val Pro Glu His Leu         
45                  50                  55                  60          

ctc cat gcc ctc gcc tgc ctg cag ggc ccc ggt gtg gcc ccg gtg ctg      241
Leu His Ala Leu Ala Cys Leu Gln Gly Pro Gly Val Ala Pro Val Leu         
                65                  70                  75              

cgc tgc gcg ccg acc ccc gcg ggt ctg tct ctc caa ctg cag cgg tcc      289
Arg Cys Ala Pro Thr Pro Ala Gly Leu Ser Leu Gln Leu Gln Arg Ser         
            80                  85                  90                  

gcc gtc ttc gag cgc gtc ctc agc gcc gtg gcc gcc tat gcc acg ccc      337
Ala Val Phe Glu Arg Val Leu Ser Ala Val Ala Ala Tyr Ala Thr Pro         
        95                  100                 105                     

gcc tcg cct gcc tcg ctg ggc cag cgc gtc tta cta cac tgc cca gca      385
Ala Ser Pro Ala Ser Leu Gly Gln Arg Val Leu Leu His Cys Pro Ala         
    110                 115                 120                         

ctg cgc agc tcc ccc tgc gca ctc cgc ttg agc cag ctg cgt acg gtg      433
Leu Arg Ser Ser Pro Cys Ala Leu Arg Leu Ser Gln Leu Arg Thr Val         
125                 130                 135                 140         

ctc gtg gcc gat cac ctg gcg cga gcc ctg cgc gct cac ggg gtg tgc      481
Leu Val Ala Asp His Leu Ala Arg Ala Leu Arg Ala His Gly Val Cys         
                145                 150                 155             

gtg cgc cta gtg cca gct gtg cgg gat ccg cac atg ctg acc ttc ctg      529
Val Arg Leu Val Pro Ala Val Arg Asp Pro His Met Leu Thr Phe Leu         
            160                 165                 170                 

cag caa ctg cgg gtg gac tgg ccc gct gcc tcg gag aga gct tcc tcc      577
Gln Gln Leu Arg Val Asp Trp Pro Ala Ala Ser Glu Arg Ala Ser Ser         
        175                 180                 185                     

cac acc ctg agg agc cac gcc ctt gaa gaa ctt acc tct gct aat gac      625
His Thr Leu Arg Ser His Ala Leu Glu Glu Leu Thr Ser Ala Asn Asp         
    190                 195                 200                         

ggg agg aca ctg tcc cct ggc atc cta ggc aga ctg tgt ctg aag gag      673
Gly Arg Thr Leu Ser Pro Gly Ile Leu Gly Arg Leu Cys Leu Lys Glu         
205                 210                 215                 220         

ctg gtg gaa gaa cag ggc cgc aca gct ggc tat gac ccc aac ctg gac      721
Leu Val Glu Glu Gln Gly Arg Thr Ala Gly Tyr Asp Pro Asn Leu Asp         
                225                 230                 235             

aac tgt ctg gtg act gag gat ctc ctc tct gtg ctg gct gag ctg caa      769
Asn Cys Leu Val Thr Glu Asp Leu Leu Ser Val Leu Ala Glu Leu Gln         
            240                 245                 250                 

gag gct cta tgg cat tgg ccc gag gac agc cac cca ggc ctg gct ggg      817
Glu Ala Leu Trp His Trp Pro Glu Asp Ser His Pro Gly Leu Ala Gly         
        255                 260                 265                     

gcc tca gat act ggt aca ggc ggc tgc ctg gtt gta cat gtt gtt agc      865
Ala Ser Asp Thr Gly Thr Gly Gly Cys Leu Val Val His Val Val Ser         
    270                 275                 280                         

tgt gag gag gag ttc cag caa cag aag ttg gac ctg ctt tgg cgg aag      913
Cys Glu Glu Glu Phe Gln Gln Gln Lys Leu Asp Leu Leu Trp Arg Lys         
285                 290                 295                 300         

ttg gtt gac aag gct cca ctc aga cag aag cac ctc atc tgt ggc cct      961
Leu Val Asp Lys Ala Pro Leu Arg Gln Lys His Leu Ile Cys Gly Pro         
                305                 310                 315             

gtg aaa gta gct ggt gca cct ggc act ctg atg act gcc cct gag tac     1009
Val Lys Val Ala Gly Ala Pro Gly Thr Leu Met Thr Ala Pro Glu Tyr         
            320                 325                 330                 

tac gag ttc cgg cat acc cag gtg tgc aag gcc tca gca ctg aag cat     1057
Tyr Glu Phe Arg His Thr Gln Val Cys Lys Ala Ser Ala Leu Lys His         
        335                 340                 345                     

ggt ggg gat ctg gca caa gac cca gcc tgg aca gag atc ttt ggt gtt     1105
Gly Gly Asp Leu Ala Gln Asp Pro Ala Trp Thr Glu Ile Phe Gly Val         
    350                 355                 360                         

ctc tct gtg gcc acc atc aag ttt gag atg ctg agc aca gcc cca cag     1153
Leu Ser Val Ala Thr Ile Lys Phe Glu Met Leu Ser Thr Ala Pro Gln         
365                 370                 375                 380         

agt cag ctc ttc ctg gct ctg gct gac agc agt atc tcc acg aag ggc     1201
Ser Gln Leu Phe Leu Ala Leu Ala Asp Ser Ser Ile Ser Thr Lys Gly         
                385                 390                 395             

aca aag agt ggc acc ttt gtc atg tat aat tgt gcc cgt ctt gcc aca     1249
Thr Lys Ser Gly Thr Phe Val Met Tyr Asn Cys Ala Arg Leu Ala Thr         
            400                 405                 410                 

ctc ttt gag agt tac aag tgt agt atg gaa caa ggt ctg tac ccc act     1297
Leu Phe Glu Ser Tyr Lys Cys Ser Met Glu Gln Gly Leu Tyr Pro Thr         
        415                 420                 425                     

ttt cct cct gtg agc agt ctg gac ttc tca ctg cta cat gat gag tat     1345
Phe Pro Pro Val Ser Ser Leu Asp Phe Ser Leu Leu His Asp Glu Tyr         
    430                 435                 440                         

cct ccc ctt tcc gga tct gct gag ccg gac agc agt gct gga ctg cac     1393
Pro Pro Leu Ser Gly Ser Ala Glu Pro Asp Ser Ser Ala Gly Leu His         
445                 450                 455                 460         

agc ccc ggg gct cca cat tgc tgt acg cac aga gat gat atg caa gtt     1441
Ser Pro Gly Ala Pro His Cys Cys Thr His Arg Asp Asp Met Gln Val         
                465                 470                 475             

cct ggt aca gct cag cat gga ttt cag ctc cta cta caa ccg ggt aca     1489
Pro Gly Thr Ala Gln His Gly Phe Gln Leu Leu Leu Gln Pro Gly Thr         
            480                 485                 490                 

cat cct ggg gga gcc tcg acc aca cct ctt tgg tca gat gtt cgt ccg     1537
His Pro Gly Gly Ala Ser Thr Thr Pro Leu Trp Ser Asp Val Arg Pro         
        495                 500                 505                     

cct gca gct tyt gag agc tgt gcg tga ggtgctccat actggcctgg           1584
Pro Ala Ala Xaa Glu Ser Cys Ala                                         
    510                 515                                             

ctatgctggg tctccctcca ctgagccaca tttaaggcca cagaggctcc aatacctggg   1644

aatgttcaca aagtcatcaa ctggaaaaaa agcaaaaacc cacggccaaa ataaattggt   1704

actgtttgtt acaaaaaaaa aaaaaaaaaa                                    1734


<210>  46
<211>  516
<212>  PRT
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (512)..(512)
<223>  The 'Xaa' at location 512 stands for Ser, or Phe. 

<400>  46

Met Ala Thr Arg Arg Leu Gly Val Gly Glu Thr Leu Gly Ala Leu Asn 
1               5                   10                  15      


Ala Ala Leu Gly Pro Gly Gly Pro Val Trp Ile Lys Glu Thr Arg Thr 
            20                  25                  30          


Arg His Leu Arg Ser Arg Asp Phe Leu Ala Pro His Arg Ala Leu Gln 
        35                  40                  45              


Ala Arg Phe Asp Asp Gly Gln Val Pro Glu His Leu Leu His Ala Leu 
    50                  55                  60                  


Ala Cys Leu Gln Gly Pro Gly Val Ala Pro Val Leu Arg Cys Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Gly Leu Ser Leu Gln Leu Gln Arg Ser Ala Val Phe Glu 
                85                  90                  95      


Arg Val Leu Ser Ala Val Ala Ala Tyr Ala Thr Pro Ala Ser Pro Ala 
            100                 105                 110         


Ser Leu Gly Gln Arg Val Leu Leu His Cys Pro Ala Leu Arg Ser Ser 
        115                 120                 125             


Pro Cys Ala Leu Arg Leu Ser Gln Leu Arg Thr Val Leu Val Ala Asp 
    130                 135                 140                 


His Leu Ala Arg Ala Leu Arg Ala His Gly Val Cys Val Arg Leu Val 
145                 150                 155                 160 


Pro Ala Val Arg Asp Pro His Met Leu Thr Phe Leu Gln Gln Leu Arg 
                165                 170                 175     


Val Asp Trp Pro Ala Ala Ser Glu Arg Ala Ser Ser His Thr Leu Arg 
            180                 185                 190         


Ser His Ala Leu Glu Glu Leu Thr Ser Ala Asn Asp Gly Arg Thr Leu 
        195                 200                 205             


Ser Pro Gly Ile Leu Gly Arg Leu Cys Leu Lys Glu Leu Val Glu Glu 
    210                 215                 220                 


Gln Gly Arg Thr Ala Gly Tyr Asp Pro Asn Leu Asp Asn Cys Leu Val 
225                 230                 235                 240 


Thr Glu Asp Leu Leu Ser Val Leu Ala Glu Leu Gln Glu Ala Leu Trp 
                245                 250                 255     


His Trp Pro Glu Asp Ser His Pro Gly Leu Ala Gly Ala Ser Asp Thr 
            260                 265                 270         


Gly Thr Gly Gly Cys Leu Val Val His Val Val Ser Cys Glu Glu Glu 
        275                 280                 285             


Phe Gln Gln Gln Lys Leu Asp Leu Leu Trp Arg Lys Leu Val Asp Lys 
    290                 295                 300                 


Ala Pro Leu Arg Gln Lys His Leu Ile Cys Gly Pro Val Lys Val Ala 
305                 310                 315                 320 


Gly Ala Pro Gly Thr Leu Met Thr Ala Pro Glu Tyr Tyr Glu Phe Arg 
                325                 330                 335     


His Thr Gln Val Cys Lys Ala Ser Ala Leu Lys His Gly Gly Asp Leu 
            340                 345                 350         


Ala Gln Asp Pro Ala Trp Thr Glu Ile Phe Gly Val Leu Ser Val Ala 
        355                 360                 365             


Thr Ile Lys Phe Glu Met Leu Ser Thr Ala Pro Gln Ser Gln Leu Phe 
    370                 375                 380                 


Leu Ala Leu Ala Asp Ser Ser Ile Ser Thr Lys Gly Thr Lys Ser Gly 
385                 390                 395                 400 


Thr Phe Val Met Tyr Asn Cys Ala Arg Leu Ala Thr Leu Phe Glu Ser 
                405                 410                 415     


Tyr Lys Cys Ser Met Glu Gln Gly Leu Tyr Pro Thr Phe Pro Pro Val 
            420                 425                 430         


Ser Ser Leu Asp Phe Ser Leu Leu His Asp Glu Tyr Pro Pro Leu Ser 
        435                 440                 445             


Gly Ser Ala Glu Pro Asp Ser Ser Ala Gly Leu His Ser Pro Gly Ala 
    450                 455                 460                 


Pro His Cys Cys Thr His Arg Asp Asp Met Gln Val Pro Gly Thr Ala 
465                 470                 475                 480 


Gln His Gly Phe Gln Leu Leu Leu Gln Pro Gly Thr His Pro Gly Gly 
                485                 490                 495     


Ala Ser Thr Thr Pro Leu Trp Ser Asp Val Arg Pro Pro Ala Ala Xaa 
            500                 505                 510         


Glu Ser Cys Ala 
        515     


<210>  47
<211>  1745
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (14)..(1630)
<223>  

<400>  47
ccttccggtc acc atg gcg acc agg cgc ctt ggg gtc ggg gag acg ctg        49
               Met Ala Thr Arg Arg Leu Gly Val Gly Glu Thr Leu          
               1               5                   10                   

ggg gcc ctc aac gcg gcc ctg ggg cca ggc ggt ccg gtg tgg atc aag       97
Gly Ala Leu Asn Ala Ala Leu Gly Pro Gly Gly Pro Val Trp Ile Lys         
        15                  20                  25                      

gag acg cgc acc cgc cac ctg cgt tcc cga gac ttt ctg gca ccg cac      145
Glu Thr Arg Thr Arg His Leu Arg Ser Arg Asp Phe Leu Ala Pro His         
    30                  35                  40                          

cgc gcg ctg cag gcg cgc ttc gat gac ggc cag gtt ccg gag cat ttg      193
Arg Ala Leu Gln Ala Arg Phe Asp Asp Gly Gln Val Pro Glu His Leu         
45                  50                  55                  60          

ctc cat gcc ctc gcc tgc ctg cag ggc ccc ggt gtg gcc ccg gtg ctg      241
Leu His Ala Leu Ala Cys Leu Gln Gly Pro Gly Val Ala Pro Val Leu         
                65                  70                  75              

cgc tgc gcg ccg acc ccc gcg ggt ctg tct ctc caa ctg cag cgg tcc      289
Arg Cys Ala Pro Thr Pro Ala Gly Leu Ser Leu Gln Leu Gln Arg Ser         
            80                  85                  90                  

gcc gtc ttc gag cgc gtc ctc agc gcc gtg gcc gcc tat gcc acg ccc      337
Ala Val Phe Glu Arg Val Leu Ser Ala Val Ala Ala Tyr Ala Thr Pro         
        95                  100                 105                     

gcc tcg cct gcc tcg ctg ggc cag cgc gtc tta cta cac tgc cca gca      385
Ala Ser Pro Ala Ser Leu Gly Gln Arg Val Leu Leu His Cys Pro Ala         
    110                 115                 120                         

ctg cgc agc tcc ccc tgc gca ctc cgc ttg agc cag ctg cgt acg gtg      433
Leu Arg Ser Ser Pro Cys Ala Leu Arg Leu Ser Gln Leu Arg Thr Val         
125                 130                 135                 140         

ctc gtg gcc gat cac ctg gcg cga gcc ctg cgc gct cac ggg gtg tgc      481
Leu Val Ala Asp His Leu Ala Arg Ala Leu Arg Ala His Gly Val Cys         
                145                 150                 155             

gtg cgc cta gtg cca gct gtg cgg gat ccg cac atg ctg acc ttc ctg      529
Val Arg Leu Val Pro Ala Val Arg Asp Pro His Met Leu Thr Phe Leu         
            160                 165                 170                 

cag caa ctg cgg gtg gac tgg ccc gct gcc tcg gag aga gct tcc tcc      577
Gln Gln Leu Arg Val Asp Trp Pro Ala Ala Ser Glu Arg Ala Ser Ser         
        175                 180                 185                     

cac acc ctg agg agc cac gcc ctt gaa gaa ctt acc tct gct aat gac      625
His Thr Leu Arg Ser His Ala Leu Glu Glu Leu Thr Ser Ala Asn Asp         
    190                 195                 200                         

ggg agg aca ctg tcc cct ggc atc cta ggc aga ctg tgt ctg aag gag      673
Gly Arg Thr Leu Ser Pro Gly Ile Leu Gly Arg Leu Cys Leu Lys Glu         
205                 210                 215                 220         

ctg gtg gaa gaa cag ggc cgc aca gct ggc tat gac ccc aac ctg gac      721
Leu Val Glu Glu Gln Gly Arg Thr Ala Gly Tyr Asp Pro Asn Leu Asp         
                225                 230                 235             

aac tgt ctg gtg act gag gat ctc ctc tct gtg ctg gct gag ctg caa      769
Asn Cys Leu Val Thr Glu Asp Leu Leu Ser Val Leu Ala Glu Leu Gln         
            240                 245                 250                 

gag gct cta tgg cat tgg ccc gag gac agc cac cca ggc ctg gct ggg      817
Glu Ala Leu Trp His Trp Pro Glu Asp Ser His Pro Gly Leu Ala Gly         
        255                 260                 265                     

gcc tca gat act ggt aca ggc ggc tgc ctg gtt gta cat gtt gtt agc      865
Ala Ser Asp Thr Gly Thr Gly Gly Cys Leu Val Val His Val Val Ser         
    270                 275                 280                         

tgt gag gag gag ttc cag caa cag aag ttg gac ctg ctt tgg cgg aag      913
Cys Glu Glu Glu Phe Gln Gln Gln Lys Leu Asp Leu Leu Trp Arg Lys         
285                 290                 295                 300         

ttg gtt gac aag gct cca ctc aga cag aag cac ctc atc tgt ggc cct      961
Leu Val Asp Lys Ala Pro Leu Arg Gln Lys His Leu Ile Cys Gly Pro         
                305                 310                 315             

gtg aaa gta gct ggt gca cct ggc act ctg atg act gcc cct gag tac     1009
Val Lys Val Ala Gly Ala Pro Gly Thr Leu Met Thr Ala Pro Glu Tyr         
            320                 325                 330                 

tac gag ttc cgg cat acc cag gtg tgc aag gcc tca gca ctg aag cat     1057
Tyr Glu Phe Arg His Thr Gln Val Cys Lys Ala Ser Ala Leu Lys His         
        335                 340                 345                     

ggt ggg gat ctg gca caa gac cca gcc tgg aca gag atc ttt ggt gtt     1105
Gly Gly Asp Leu Ala Gln Asp Pro Ala Trp Thr Glu Ile Phe Gly Val         
    350                 355                 360                         

ctc tct gtg gcc acc atc aag ttt gag atg ctg agc aca gcc cca cag     1153
Leu Ser Val Ala Thr Ile Lys Phe Glu Met Leu Ser Thr Ala Pro Gln         
365                 370                 375                 380         

agt cag ctc ttc ctg gct ctg gct gac agc agt atc tcc acg aag ggc     1201
Ser Gln Leu Phe Leu Ala Leu Ala Asp Ser Ser Ile Ser Thr Lys Gly         
                385                 390                 395             

aca aag agt ggc acc ttt gtc atg tat aat tgt gcc cgt ctt gcc aca     1249
Thr Lys Ser Gly Thr Phe Val Met Tyr Asn Cys Ala Arg Leu Ala Thr         
            400                 405                 410                 

ctc ttt gag agt tac aag tgt agt atg gaa caa ggt ctg tac ccc act     1297
Leu Phe Glu Ser Tyr Lys Cys Ser Met Glu Gln Gly Leu Tyr Pro Thr         
        415                 420                 425                     

ttt cct cct gtg agc agt ctg gac ttc tca ctg cta cat gat gag ggt     1345
Phe Pro Pro Val Ser Ser Leu Asp Phe Ser Leu Leu His Asp Glu Gly         
    430                 435                 440                         

gag tgg ttg ttg ctc ttc aac agt atc ctc ccc ttt ccg gat ctg ctg     1393
Glu Trp Leu Leu Leu Phe Asn Ser Ile Leu Pro Phe Pro Asp Leu Leu         
445                 450                 455                 460         

agc cgg aca gca gtg ctg gac tgc aca gcc ccg ggg ctc cac att gct     1441
Ser Arg Thr Ala Val Leu Asp Cys Thr Ala Pro Gly Leu His Ile Ala         
                465                 470                 475             

gta cgc aca gag atg ata tgc aag ttc ctg gta cag ctc agc atg gat     1489
Val Arg Thr Glu Met Ile Cys Lys Phe Leu Val Gln Leu Ser Met Asp         
            480                 485                 490                 

ttc agc tcc tac tac aac cgg gag cct cga cca cac ctc ttt ggt cag     1537
Phe Ser Ser Tyr Tyr Asn Arg Glu Pro Arg Pro His Leu Phe Gly Gln         
        495                 500                 505                     

atg ttc gtc cgc ctg cag ctt ctg aga gct gtg cgt gag gtg ctc cat     1585
Met Phe Val Arg Leu Gln Leu Leu Arg Ala Val Arg Glu Val Leu His         
    510                 515                 520                         

act ggc ctg gct atg ctg ggt ctc cct cca ctg agc cac att taa         1630
Thr Gly Leu Ala Met Leu Gly Leu Pro Pro Leu Ser His Ile                 
525                 530                 535                             

ggccacagag gctccaatac ctgggaatgt tcacaaagtc atcaactgga aaaaaagcaa   1690

aaacccacgg ccaaaataaa ttggtactgt ttgttacaaa aaaaaaaaaa aaaaa        1745


<210>  48
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Thr Arg Arg Leu Gly Val Gly Glu Thr Leu Gly Ala Leu Asn 
1               5                   10                  15      


Ala Ala Leu Gly Pro Gly Gly Pro Val Trp Ile Lys Glu Thr Arg Thr 
            20                  25                  30          


Arg His Leu Arg Ser Arg Asp Phe Leu Ala Pro His Arg Ala Leu Gln 
        35                  40                  45              


Ala Arg Phe Asp Asp Gly Gln Val Pro Glu His Leu Leu His Ala Leu 
    50                  55                  60                  


Ala Cys Leu Gln Gly Pro Gly Val Ala Pro Val Leu Arg Cys Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Gly Leu Ser Leu Gln Leu Gln Arg Ser Ala Val Phe Glu 
                85                  90                  95      


Arg Val Leu Ser Ala Val Ala Ala Tyr Ala Thr Pro Ala Ser Pro Ala 
            100                 105                 110         


Ser Leu Gly Gln Arg Val Leu Leu His Cys Pro Ala Leu Arg Ser Ser 
        115                 120                 125             


Pro Cys Ala Leu Arg Leu Ser Gln Leu Arg Thr Val Leu Val Ala Asp 
    130                 135                 140                 


His Leu Ala Arg Ala Leu Arg Ala His Gly Val Cys Val Arg Leu Val 
145                 150                 155                 160 


Pro Ala Val Arg Asp Pro His Met Leu Thr Phe Leu Gln Gln Leu Arg 
                165                 170                 175     


Val Asp Trp Pro Ala Ala Ser Glu Arg Ala Ser Ser His Thr Leu Arg 
            180                 185                 190         


Ser His Ala Leu Glu Glu Leu Thr Ser Ala Asn Asp Gly Arg Thr Leu 
        195                 200                 205             


Ser Pro Gly Ile Leu Gly Arg Leu Cys Leu Lys Glu Leu Val Glu Glu 
    210                 215                 220                 


Gln Gly Arg Thr Ala Gly Tyr Asp Pro Asn Leu Asp Asn Cys Leu Val 
225                 230                 235                 240 


Thr Glu Asp Leu Leu Ser Val Leu Ala Glu Leu Gln Glu Ala Leu Trp 
                245                 250                 255     


His Trp Pro Glu Asp Ser His Pro Gly Leu Ala Gly Ala Ser Asp Thr 
            260                 265                 270         


Gly Thr Gly Gly Cys Leu Val Val His Val Val Ser Cys Glu Glu Glu 
        275                 280                 285             


Phe Gln Gln Gln Lys Leu Asp Leu Leu Trp Arg Lys Leu Val Asp Lys 
    290                 295                 300                 


Ala Pro Leu Arg Gln Lys His Leu Ile Cys Gly Pro Val Lys Val Ala 
305                 310                 315                 320 


Gly Ala Pro Gly Thr Leu Met Thr Ala Pro Glu Tyr Tyr Glu Phe Arg 
                325                 330                 335     


His Thr Gln Val Cys Lys Ala Ser Ala Leu Lys His Gly Gly Asp Leu 
            340                 345                 350         


Ala Gln Asp Pro Ala Trp Thr Glu Ile Phe Gly Val Leu Ser Val Ala 
        355                 360                 365             


Thr Ile Lys Phe Glu Met Leu Ser Thr Ala Pro Gln Ser Gln Leu Phe 
    370                 375                 380                 


Leu Ala Leu Ala Asp Ser Ser Ile Ser Thr Lys Gly Thr Lys Ser Gly 
385                 390                 395                 400 


Thr Phe Val Met Tyr Asn Cys Ala Arg Leu Ala Thr Leu Phe Glu Ser 
                405                 410                 415     


Tyr Lys Cys Ser Met Glu Gln Gly Leu Tyr Pro Thr Phe Pro Pro Val 
            420                 425                 430         


Ser Ser Leu Asp Phe Ser Leu Leu His Asp Glu Gly Glu Trp Leu Leu 
        435                 440                 445             


Leu Phe Asn Ser Ile Leu Pro Phe Pro Asp Leu Leu Ser Arg Thr Ala 
    450                 455                 460                 


Val Leu Asp Cys Thr Ala Pro Gly Leu His Ile Ala Val Arg Thr Glu 
465                 470                 475                 480 


Met Ile Cys Lys Phe Leu Val Gln Leu Ser Met Asp Phe Ser Ser Tyr 
                485                 490                 495     


Tyr Asn Arg Glu Pro Arg Pro His Leu Phe Gly Gln Met Phe Val Arg 
            500                 505                 510         


Leu Gln Leu Leu Arg Ala Val Arg Glu Val Leu His Thr Gly Leu Ala 
        515                 520                 525             


Met Leu Gly Leu Pro Pro Leu Ser His Ile 
    530                 535             


<210>  49
<211>  1941
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (14)..(1771)
<223>  

<400>  49
ccttccggtc acc atg gcg acc agg cgc ctt ggg gtc ggg gag acg ctg        49
               Met Ala Thr Arg Arg Leu Gly Val Gly Glu Thr Leu          
               1               5                   10                   

ggg gcc ctc aac gcg gcc ctg ggg cca ggc ggt ccg gtg tgg atc aag       97
Gly Ala Leu Asn Ala Ala Leu Gly Pro Gly Gly Pro Val Trp Ile Lys         
        15                  20                  25                      

gag acg cgc acc cgc cac ctg cgt tcc cga gac ttt ctg gca ccg cac      145
Glu Thr Arg Thr Arg His Leu Arg Ser Arg Asp Phe Leu Ala Pro His         
    30                  35                  40                          

cgc gcg ctg cag gcg cgc ttc gat gac ggc cag gtg ggc gtg agc cgg      193
Arg Ala Leu Gln Ala Arg Phe Asp Asp Gly Gln Val Gly Val Ser Arg         
45                  50                  55                  60          

gcg ggg ccg tgc ggc cgg gag atg ggc ccc gtg ccg tgg ctc ttt tac      241
Ala Gly Pro Cys Gly Arg Glu Met Gly Pro Val Pro Trp Leu Phe Tyr         
                65                  70                  75              

acg ccc gtt ctc ccg cag gtt ccg gag cat ttg ctc cat gcc ctc gcc      289
Thr Pro Val Leu Pro Gln Val Pro Glu His Leu Leu His Ala Leu Ala         
            80                  85                  90                  

tgc ctg cag ggc ccc ggt gtg gcc ccg gtg ctg cgc tgc gcg ccg acc      337
Cys Leu Gln Gly Pro Gly Val Ala Pro Val Leu Arg Cys Ala Pro Thr         
        95                  100                 105                     

ccc gcg ggt ctg tct ctc caa ctg cag cgg tcc gcc gtc ttc gag cgc      385
Pro Ala Gly Leu Ser Leu Gln Leu Gln Arg Ser Ala Val Phe Glu Arg         
    110                 115                 120                         

gtc ctc agc gcc gtg gcc gcc tat gcc acg ccc gcc tcg cct gcc tcg      433
Val Leu Ser Ala Val Ala Ala Tyr Ala Thr Pro Ala Ser Pro Ala Ser         
125                 130                 135                 140         

ctg ggc cag cgc gtc tta cta cac tgc cca gca ctg cgc agc tcc ccc      481
Leu Gly Gln Arg Val Leu Leu His Cys Pro Ala Leu Arg Ser Ser Pro         
                145                 150                 155             

tgc gca ctc cgc ttg agc cag ctg cgt acg gtg ctc gtg gcc gat cac      529
Cys Ala Leu Arg Leu Ser Gln Leu Arg Thr Val Leu Val Ala Asp His         
            160                 165                 170                 

ctg gcg cga gcc ctg cgc gct cac ggg gtg tgc gtg cgc cta gtg cca      577
Leu Ala Arg Ala Leu Arg Ala His Gly Val Cys Val Arg Leu Val Pro         
        175                 180                 185                     

gct gtg cgg gat ccg cac atg ctg acc ttc ctg cag caa ctg cgg gtg      625
Ala Val Arg Asp Pro His Met Leu Thr Phe Leu Gln Gln Leu Arg Val         
    190                 195                 200                         

gac tgg ccc gct gcc tcg gag aga gct tcc tcc cac acc ctg agg agc      673
Asp Trp Pro Ala Ala Ser Glu Arg Ala Ser Ser His Thr Leu Arg Ser         
205                 210                 215                 220         

cac gcc ctt gaa gaa ctt acc tct gct aat gac ggg agg aca ctg tcc      721
His Ala Leu Glu Glu Leu Thr Ser Ala Asn Asp Gly Arg Thr Leu Ser         
                225                 230                 235             

cct ggc atc cta ggc aga ctg tgt ctg aag gag ctg gtg gaa gaa cag      769
Pro Gly Ile Leu Gly Arg Leu Cys Leu Lys Glu Leu Val Glu Glu Gln         
            240                 245                 250                 

ggc cgc aca gct ggc tat gac ccc aac ctg gac aac tgt ctg gtg act      817
Gly Arg Thr Ala Gly Tyr Asp Pro Asn Leu Asp Asn Cys Leu Val Thr         
        255                 260                 265                     

gag gat ctc ctc tct gtg ctg gct gag ctg caa gag gct cta tgg cat      865
Glu Asp Leu Leu Ser Val Leu Ala Glu Leu Gln Glu Ala Leu Trp His         
    270                 275                 280                         

tgg ccc gag gac agc cac cca ggc ctg gct ggg gcc tca gat act ggt      913
Trp Pro Glu Asp Ser His Pro Gly Leu Ala Gly Ala Ser Asp Thr Gly         
285                 290                 295                 300         

aca ggc ggc tgc ctg gtt gta cat gtt gtt agc tgt gag gag gag ttc      961
Thr Gly Gly Cys Leu Val Val His Val Val Ser Cys Glu Glu Glu Phe         
                305                 310                 315             

cag caa cag aag ttg gac ctg ctt tgg cgg aag ttg gtt gac aag gct     1009
Gln Gln Gln Lys Leu Asp Leu Leu Trp Arg Lys Leu Val Asp Lys Ala         
            320                 325                 330                 

cca ctc aga cag aag cac ctc atc tgt ggc cct gtg aaa gta gct ggt     1057
Pro Leu Arg Gln Lys His Leu Ile Cys Gly Pro Val Lys Val Ala Gly         
        335                 340                 345                     

gca cct ggc act ctg atg act gcc cct gag tac tac gag ttc cgg cat     1105
Ala Pro Gly Thr Leu Met Thr Ala Pro Glu Tyr Tyr Glu Phe Arg His         
    350                 355                 360                         

acc cag gtg tgc aag gcc tca gca ctg aag cat ggt ggg gat ctg gca     1153
Thr Gln Val Cys Lys Ala Ser Ala Leu Lys His Gly Gly Asp Leu Ala         
365                 370                 375                 380         

caa gac cca gcc tgg aca gag atc ttt ggt gtt ctc tct gtg gcc acc     1201
Gln Asp Pro Ala Trp Thr Glu Ile Phe Gly Val Leu Ser Val Ala Thr         
                385                 390                 395             

atc aag ttt gag atg ctg agc aca gcc cca cag agt cag ctc ttc ctg     1249
Ile Lys Phe Glu Met Leu Ser Thr Ala Pro Gln Ser Gln Leu Phe Leu         
            400                 405                 410                 

gct ctg gct gac agc agt atc tcc acg aag ggc aca aag agt ggc acc     1297
Ala Leu Ala Asp Ser Ser Ile Ser Thr Lys Gly Thr Lys Ser Gly Thr         
        415                 420                 425                     

ttt gtc atg tat aat tgt gcc cgt ctt gcc aca ctc ttt gag agt tac     1345
Phe Val Met Tyr Asn Cys Ala Arg Leu Ala Thr Leu Phe Glu Ser Tyr         
    430                 435                 440                         

aag tgt agt atg gaa caa ggt ctg tac ccc act ttt cct cct gtg agc     1393
Lys Cys Ser Met Glu Gln Gly Leu Tyr Pro Thr Phe Pro Pro Val Ser         
445                 450                 455                 460         

agt ctg gac ttc tca ctg cta cat gat gag ggt gag tgg ttg ttg ctc     1441
Ser Leu Asp Phe Ser Leu Leu His Asp Glu Gly Glu Trp Leu Leu Leu         
                465                 470                 475             

ttc aac agt atc ctc ccc ttt ccg gat ctg ctg agc cgg aca gca gtg     1489
Phe Asn Ser Ile Leu Pro Phe Pro Asp Leu Leu Ser Arg Thr Ala Val         
            480                 485                 490                 

ctg gac tgc aca gcc ccg ggg ctc cac att gct gta cgc aca gag atg     1537
Leu Asp Cys Thr Ala Pro Gly Leu His Ile Ala Val Arg Thr Glu Met         
        495                 500                 505                     

gtg agg cat aga caa cca gga cac tct aca ctc tat tct tta ttc tgg     1585
Val Arg His Arg Gln Pro Gly His Ser Thr Leu Tyr Ser Leu Phe Trp         
    510                 515                 520                         

cct ggg gca caa gag caa aga gat ggg cca gtg act cag tct ctg tct     1633
Pro Gly Ala Gln Glu Gln Arg Asp Gly Pro Val Thr Gln Ser Leu Ser         
525                 530                 535                 540         

cta gat atg caa gtt cct ggt aca gct cag cat gga ttt cag ctc cta     1681
Leu Asp Met Gln Val Pro Gly Thr Ala Gln His Gly Phe Gln Leu Leu         
                545                 550                 555             

cta caa ccg ggt aca cat cct ggg gga gcc tcg acc aca cct ctt tgg     1729
Leu Gln Pro Gly Thr His Pro Gly Gly Ala Ser Thr Thr Pro Leu Trp         
            560                 565                 570                 

tca gat gtt cgt ccg cct gca gct tct gag agc tgt gcg tga             1771
Ser Asp Val Arg Pro Pro Ala Ala Ser Glu Ser Cys Ala                     
        575                 580                 585                     

ggtgctccat actggcctgg ctatgctggg tctccctcca ctgagccaca tttaaggcca   1831

cagaggctcc aatacctggg aatgttcaca aagtcatcaa ctggaaaaaa agcaaaaacc   1891

cacggccaaa ataaattggt actgtttgtt acaaaaaaaa aaaaaaaaaa              1941


<210>  50
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Thr Arg Arg Leu Gly Val Gly Glu Thr Leu Gly Ala Leu Asn 
1               5                   10                  15      


Ala Ala Leu Gly Pro Gly Gly Pro Val Trp Ile Lys Glu Thr Arg Thr 
            20                  25                  30          


Arg His Leu Arg Ser Arg Asp Phe Leu Ala Pro His Arg Ala Leu Gln 
        35                  40                  45              


Ala Arg Phe Asp Asp Gly Gln Val Gly Val Ser Arg Ala Gly Pro Cys 
    50                  55                  60                  


Gly Arg Glu Met Gly Pro Val Pro Trp Leu Phe Tyr Thr Pro Val Leu 
65                  70                  75                  80  


Pro Gln Val Pro Glu His Leu Leu His Ala Leu Ala Cys Leu Gln Gly 
                85                  90                  95      


Pro Gly Val Ala Pro Val Leu Arg Cys Ala Pro Thr Pro Ala Gly Leu 
            100                 105                 110         


Ser Leu Gln Leu Gln Arg Ser Ala Val Phe Glu Arg Val Leu Ser Ala 
        115                 120                 125             


Val Ala Ala Tyr Ala Thr Pro Ala Ser Pro Ala Ser Leu Gly Gln Arg 
    130                 135                 140                 


Val Leu Leu His Cys Pro Ala Leu Arg Ser Ser Pro Cys Ala Leu Arg 
145                 150                 155                 160 


Leu Ser Gln Leu Arg Thr Val Leu Val Ala Asp His Leu Ala Arg Ala 
                165                 170                 175     


Leu Arg Ala His Gly Val Cys Val Arg Leu Val Pro Ala Val Arg Asp 
            180                 185                 190         


Pro His Met Leu Thr Phe Leu Gln Gln Leu Arg Val Asp Trp Pro Ala 
        195                 200                 205             


Ala Ser Glu Arg Ala Ser Ser His Thr Leu Arg Ser His Ala Leu Glu 
    210                 215                 220                 


Glu Leu Thr Ser Ala Asn Asp Gly Arg Thr Leu Ser Pro Gly Ile Leu 
225                 230                 235                 240 


Gly Arg Leu Cys Leu Lys Glu Leu Val Glu Glu Gln Gly Arg Thr Ala 
                245                 250                 255     


Gly Tyr Asp Pro Asn Leu Asp Asn Cys Leu Val Thr Glu Asp Leu Leu 
            260                 265                 270         


Ser Val Leu Ala Glu Leu Gln Glu Ala Leu Trp His Trp Pro Glu Asp 
        275                 280                 285             


Ser His Pro Gly Leu Ala Gly Ala Ser Asp Thr Gly Thr Gly Gly Cys 
    290                 295                 300                 


Leu Val Val His Val Val Ser Cys Glu Glu Glu Phe Gln Gln Gln Lys 
305                 310                 315                 320 


Leu Asp Leu Leu Trp Arg Lys Leu Val Asp Lys Ala Pro Leu Arg Gln 
                325                 330                 335     


Lys His Leu Ile Cys Gly Pro Val Lys Val Ala Gly Ala Pro Gly Thr 
            340                 345                 350         


Leu Met Thr Ala Pro Glu Tyr Tyr Glu Phe Arg His Thr Gln Val Cys 
        355                 360                 365             


Lys Ala Ser Ala Leu Lys His Gly Gly Asp Leu Ala Gln Asp Pro Ala 
    370                 375                 380                 


Trp Thr Glu Ile Phe Gly Val Leu Ser Val Ala Thr Ile Lys Phe Glu 
385                 390                 395                 400 


Met Leu Ser Thr Ala Pro Gln Ser Gln Leu Phe Leu Ala Leu Ala Asp 
                405                 410                 415     


Ser Ser Ile Ser Thr Lys Gly Thr Lys Ser Gly Thr Phe Val Met Tyr 
            420                 425                 430         


Asn Cys Ala Arg Leu Ala Thr Leu Phe Glu Ser Tyr Lys Cys Ser Met 
        435                 440                 445             


Glu Gln Gly Leu Tyr Pro Thr Phe Pro Pro Val Ser Ser Leu Asp Phe 
    450                 455                 460                 


Ser Leu Leu His Asp Glu Gly Glu Trp Leu Leu Leu Phe Asn Ser Ile 
465                 470                 475                 480 


Leu Pro Phe Pro Asp Leu Leu Ser Arg Thr Ala Val Leu Asp Cys Thr 
                485                 490                 495     


Ala Pro Gly Leu His Ile Ala Val Arg Thr Glu Met Val Arg His Arg 
            500                 505                 510         


Gln Pro Gly His Ser Thr Leu Tyr Ser Leu Phe Trp Pro Gly Ala Gln 
        515                 520                 525             


Glu Gln Arg Asp Gly Pro Val Thr Gln Ser Leu Ser Leu Asp Met Gln 
    530                 535                 540                 


Val Pro Gly Thr Ala Gln His Gly Phe Gln Leu Leu Leu Gln Pro Gly 
545                 550                 555                 560 


Thr His Pro Gly Gly Ala Ser Thr Thr Pro Leu Trp Ser Asp Val Arg 
                565                 570                 575     


Pro Pro Ala Ala Ser Glu Ser Cys Ala 
            580                 585 


<210>  51
<211>  4295
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (219)..(1610)
<223>  

<400>  51
ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg     60

tgatgcggtt ttggcagtac accaatgggc gtggatagcg gtttgactca cggggatttc    120

caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact    180

ttccaaaatg tcgtaataac cccgccccgt tgacgcaa atg ggc ggt agg cgt gta    236
                                          Met Gly Gly Arg Arg Val       
                                          1               5             

cgg tgg gag gtc tat ata agc aga gct cgt tta gtg aac cgt cag aat      284
Arg Trp Glu Val Tyr Ile Ser Arg Ala Arg Leu Val Asn Arg Gln Asn         
            10                  15                  20                  

ttt gta ata cga ctc act ata ggg cgg ccg cga att cgg cac gag ctt      332
Phe Val Ile Arg Leu Thr Ile Gly Arg Pro Arg Ile Arg His Glu Leu         
        25                  30                  35                      

agg ggt ccg ggg ccc ggg ctg ctg ctg ctg gcc gtc ctg tgc ctg ggg      380
Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Leu Cys Leu Gly         
    40                  45                  50                          

aca gcg gtg ccc tcc acg gga gcc tcg aag agc aag agg cag gct cag      428
Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln Ala Gln         
55                  60                  65                  70          

caa atg gtt cag ccc cag tcc ccg gtg gct gtc agt caa agc aag ccc      476
Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser Lys Pro         
                75                  80                  85              

ggt tgt tat gac aat gga aaa cac tat cag ata aat caa cag tgg gag      524
Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln Trp Glu         
            90                  95                  100                 

cgg acc tac cta ggc aat gcg ttg gtt tgt act tgt tat gga gga agc      572
Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly Gly Ser         
        105                 110                 115                     

cga ggt ttt aac tgc gag agt aaa cct gaa gct gaa gag act tgc ttt      620
Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr Cys Phe         
    120                 125                 130                         

gac aag tac act ggg aac act tac cga gtg ggt gac act tat gag cgt      668
Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr Glu Arg         
135                 140                 145                 150         

cct aaa gac tcc atg atc tgg gac tgt acc tgc atc ggg gct ggg cga      716
Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala Gly Arg         
                155                 160                 165             

ggg aga ata agc tgt acc atc gca aac cgc tgc cat gaa ggg ggt cag      764
Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly Gly Gln         
            170                 175                 180                 

tcc tac aag att ggt gac acc tgg agg aga cca cat gag act ggt ggt      812
Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr Gly Gly         
        185                 190                 195                     

tac atg tta gag tgt gtg tgt ctt ggt aat gga aaa gga gaa tgg acc      860
Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu Trp Thr         
    200                 205                 210                         

tgc aag ccc ata gct gag aag tgt ttt gat cat gct gct ggg act tcc      908
Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly Thr Ser         
215                 220                 225                 230         

tat gtg gtc gga gaa acg tgg gag aag ccc tac caa ggc tgg atg atg      956
Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp Met Met         
                235                 240                 245             

gta gat tgt act tgc ctg gga gaa ggc agc gga cgc atc act tgc act     1004
Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr Cys Thr         
            250                 255                 260                 

tct aga aat aga tgc aac gat cag gac aca agg aca tcc tat aga att     1052
Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr Arg Ile         
        265                 270                 275                     

gga gac acc tgg agc aag aag gat aat cga gga aac ctg ctc cag tgc     1100
Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu Gln Cys         
    280                 285                 290                         

atc tgc aca ggc aac ggc cga gga gag tgg aag tgt gag agg cac acc     1148
Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg His Thr         
295                 300                 305                 310         

tct gtg cag acc aca tcg agc gga tct ggc ccc ttc acc gat gtt cgt     1196
Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp Val Arg         
                315                 320                 325             

gca gct gtt tac caa ccg cag cct cac ccc cag cct cct ccc tat ggc     1244
Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro Tyr Gly         
            330                 335                 340                 

cac tgt gtc aca gac agt ggt gtg gtc tac tct gtg ggg atg cag tgg     1292
His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met Gln Trp         
        345                 350                 355                     

ctg aag aca caa gga aat aag caa atg ctt tgc acg tgc ctg ggc aac     1340
Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu Gly Asn         
    360                 365                 370                         

gga gtc agc tgc caa gag aca gct gta acc cag act tac ggt ggc aac     1388
Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly Gly Asn         
375                 380                 385                 390         

tca aat gga gag cca tgt gtc tta cca ttc acc tac aat ggc agg acg     1436
Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly Arg Thr         
                395                 400                 405             

ttc tac tcc tgc acc aca gaa ggg cga cag gac gga cat ctt tgg tgc     1484
Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu Trp Cys         
            410                 415                 420                 

agc aca act tcg aat tat gag cag gac cag gag gaa att cca atg gtg     1532
Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Glu Glu Ile Pro Met Val         
        425                 430                 435                     

cct tgt gcc act tcc cct tcc tat aca aca acc aca att aca ctg att     1580
Pro Cys Ala Thr Ser Pro Ser Tyr Thr Thr Thr Thr Ile Thr Leu Ile         
    440                 445                 450                         

gca ctt ctg agg gca gaa gag aca aca tga agtggtgtgg gaccacacag       1630
Ala Leu Leu Arg Ala Glu Glu Thr Thr                                     
455                 460                                                 

aactatgatg ccgaccagaa gtttgggttc tgccccatgg ctgcccacga ggaaatctgc   1690

acaaccaatg aaggggtcat gtaccgcatt ggagatcagt gggataagca gcatgacatg   1750

ggtcacatga tgaggtgcac gtgtgttggg aatggtcgtg gggaatggac atgcattgcc   1810

tactcgcagc ttcgagatca gtgcattgtt gatgacatca cttacaatgt gaacgacaca   1870

ttccacaagc gtcatgaaga ggggcacatg ctgaactgta catgcttcgg tcagggtcgg   1930

ggcaggtgga agtgtgatcc cgtcgaccaa tgccaggatt cagagactgg gacgttttat   1990

caaattggag attcatggga gaagtatgtg catggtgtca gataccagtg ctactgctat   2050

ggccgtggca ttggggagtg gcattgccaa cctttacaga cctatccaag ctcaagtggt   2110

cctgtcgaag tatttatcac tgagactccg agtcagccca actcccaccc catccagtgg   2170

aatgcaccac agccatctca catttccaag tacattctca ggtggagacc tgtgagtatc   2230

ccacccagaa accttggata ctgagtctcc taatcttatc aattctgatg gtttcttttt   2290

ttcccagctt ttgagccaac aactctgatt aactattcct atagcattta ctatatttgt   2350

ttagtgaaca aacaatatgt ggtcaattaa attgacttgt agactgaggg gattttggtt   2410

ttggttttgg gttttgtttt tttgcggtgg gggggctggt atttggaaga atttagctct   2470

ttatgttaca gaaatctttt ttgcaaggac ttagaaatga taatgcttaa gattgttctt   2530

gcccaatgtg ggaagagaat ctaaggtttt tatatgtctt gcaacctcat caaaggaaaa   2590

ttactggcat cattttcata atttgaaaaa aaaagccaaa ttaatatatt tcttttttga   2650

ttcacttttt aagtgatcat ttttaaaact ttacttttga cccactgaat ttatttagat   2710

agaaggaaaa gagatgatgg gagggaagtt tagataaagg atggaagttg gttttattta   2770

aacaatagcc ctgtgatttc ctaatgagaa gtgactagaa attgaagaaa ccaaataagg   2830

aggatattgg tcaatttagc tttagtttct cttactctct caagcctgcc ctgtttaact   2890

ccaaagttca tggctcataa tttgagaaac actgttttaa acacaggaga aaaaaaatgt   2950

ccattttaaa tcatagctat tgaattctac aattacaaag aaacaaacaa acaaaatttg   3010

accaacccag gcggttaaat ttaaactctt caggaaaaat ttaagctgtt aaaattattc   3070

tttttctaaa tttctaaagt ggagggacag aatttttcag atttaaaagg gcctcctagg   3130

tgcccagaaa attagtggaa agaaccacgt ctagacgcat ctttgatgtg tcagagttcc   3190

aaggataaaa agaaactttt aaagtcttct atactcagcc aggttatcaa tcaaatatga   3250

gggcaaaata atattttcag acagatttta ggcagtgtat cttccatata tccttttctt   3310

taagggtatt tgtagataca ctccagaaaa acaagagtga aatatgaagg aagttgtggg   3370

gtccagcaaa cagtgcttcc aaatcagacc cctgatagag gtggaaaact ttgcaatgca   3430

acaactgcgt agctggctta gaggacagcc aatacagatg gaacagaaag atgaggatgg   3490

gattgaggga tcagggattg aggtctccaa gaataaaaag ggacttcatg gaaaaagtag   3550

gcttgtggat aattaatcac aggggcaaat aatgcagtta aaataacaac atgacaatca   3610

ggtggaggaa tgtataataa acccaaatgt ggctgggtag agtggctcac acctgtaatc   3670

ccagcacttt gggaggccaa gccgggcaga ttacctgagg tcaggagttc gagaccagct   3730

tggccaacat ggcgaaaccc cgtctctact aaaaatacaa aaattagcca ggcttggggg   3790

cgcacgcctg tagtcccagc tcctcaggag ctgaggtagg agaatcactt gaacccagga   3850

ggcaaagggt gcagggagtt gagccaagat cgcgccattg caccctagcc tgggcaacag   3910

agcgagattc tgtttcaaaa aacccccaag tgtattataa ggcaataatt cctatacgaa   3970

gcaaactaaa atgcagcaat attaaggtat aaaaacaaag aggaataatt ccattgaacc   4030

ttgattctgg aaactttgat ccacccagca gtcatgatgt tagactcatt gaaaagaatg   4090

tatttctaat gcatgatgca atcggtctat agatgtgtca tggaaacttg gttgcaactt   4150

caagacaaaa taaaaagtaa acatttacat gaaaaatggt ggatatggaa ggtggagaag   4210

agaggagata acagctttat ctttcaaaat agagaattga gagatggtac caaaagctga   4270

tgaagtaaaa aaaaaaaaaa aaaaa                                         4295


<210>  52
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Gly Gly Arg Arg Val Arg Trp Glu Val Tyr Ile Ser Arg Ala Arg 
1               5                   10                  15      


Leu Val Asn Arg Gln Asn Phe Val Ile Arg Leu Thr Ile Gly Arg Pro 
            20                  25                  30          


Arg Ile Arg His Glu Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu 
        35                  40                  45              


Ala Val Leu Cys Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys 
    50                  55                  60                  


Ser Lys Arg Gln Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala 
65                  70                  75                  80  


Val Ser Gln Ser Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln 
                85                  90                  95      


Ile Asn Gln Gln Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys 
            100                 105                 110         


Thr Cys Tyr Gly Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu 
        115                 120                 125             


Ala Glu Glu Thr Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val 
    130                 135                 140                 


Gly Asp Thr Tyr Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr 
145                 150                 155                 160 


Cys Ile Gly Ala Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg 
                165                 170                 175     


Cys His Glu Gly Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg 
            180                 185                 190         


Pro His Glu Thr Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn 
        195                 200                 205             


Gly Lys Gly Glu Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp 
    210                 215                 220                 


His Ala Ala Gly Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro 
225                 230                 235                 240 


Tyr Gln Gly Trp Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser 
                245                 250                 255     


Gly Arg Ile Thr Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr 
            260                 265                 270         


Arg Thr Ser Tyr Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg 
        275                 280                 285             


Gly Asn Leu Leu Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp 
    290                 295                 300                 


Lys Cys Glu Arg His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly 
305                 310                 315                 320 


Pro Phe Thr Asp Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro 
                325                 330                 335     


Gln Pro Pro Pro Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr 
            340                 345                 350         


Ser Val Gly Met Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu 
        355                 360                 365             


Cys Thr Cys Leu Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr 
    370                 375                 380                 


Gln Thr Tyr Gly Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe 
385                 390                 395                 400 


Thr Tyr Asn Gly Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln 
                405                 410                 415     


Asp Gly His Leu Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln 
            420                 425                 430         


Glu Glu Ile Pro Met Val Pro Cys Ala Thr Ser Pro Ser Tyr Thr Thr 
        435                 440                 445             


Thr Thr Ile Thr Leu Ile Ala Leu Leu Arg Ala Glu Glu Thr Thr 
    450                 455                 460             


<210>  53
<211>  3113
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (524)..(2695)
<223>  

<400>  53
caccagcgag aaagagggag aggaagacag atagggggcg ggggaagaag aaaaagaaag     60

gtaaaaagtc ttctaggaga acctttcaca tttgcaacaa aagacctagg ggctggagag    120

agattcctgg gacgcagggc tggagtgtct atttcgagct cagcggcagg gctcgggcgc    180

gagtcgagac cctgctcgct cctctcgctt ctgaaaccga cgttcaggag cggcttttta    240

aaaacgcaag gcacaaggac ggtcacccgc gcgactatgt ttgctgattt ttcgccttgc    300

cctctttaaa agcggcctcc cattccccaa aagacacttc ccctcctccc tttgaagtgc    360

attagttgtg atttctgcct ccttttcttt tttctttctt ttttgttttg ctttttcccc    420

ccttttgaat tatgtgctgc tgttaaacaa caacaaaaaa acaacaaaac acagcagctg    480

cggacttgtc cccggctgga gcccagcgcc ccgcctggag tgg atg agc ctc tcc      535
                                                Met Ser Leu Ser         
                                                1                       

atg aga gat ccg gtc att cct ggg aca agc atg gcc tac cat ccg ttc      583
Met Arg Asp Pro Val Ile Pro Gly Thr Ser Met Ala Tyr His Pro Phe         
5                   10                  15                  20          

cta cct cac cgg gcg ccg gac ttc gcc atg agc gcg gtg ctg ggt cac      631
Leu Pro His Arg Ala Pro Asp Phe Ala Met Ser Ala Val Leu Gly His         
                25                  30                  35              

cag ccg ccg ttc ttc ccc gcg ctg acg ctg cct ccc aac ggc gcg gcg      679
Gln Pro Pro Phe Phe Pro Ala Leu Thr Leu Pro Pro Asn Gly Ala Ala         
            40                  45                  50                  

gcg ctc tcg ctg ccg ggc gcc ctg gcc aag ccg atc atg gat caa ttg      727
Ala Leu Ser Leu Pro Gly Ala Leu Ala Lys Pro Ile Met Asp Gln Leu         
        55                  60                  65                      

gtg ggg gcg gcc gag acc ggc atc ccg ttc tcc tcc ctg ggg ccc cag      775
Val Gly Ala Ala Glu Thr Gly Ile Pro Phe Ser Ser Leu Gly Pro Gln         
    70                  75                  80                          

gcg cat ctg agg cct ttg aag acc atg gag ccc gaa gaa gag gtg gag      823
Ala His Leu Arg Pro Leu Lys Thr Met Glu Pro Glu Glu Glu Val Glu         
85                  90                  95                  100         

gac gac ccc aag gtg cac ctg gag gct aaa gaa ctt tgg gat cag ttt      871
Asp Asp Pro Lys Val His Leu Glu Ala Lys Glu Leu Trp Asp Gln Phe         
                105                 110                 115             

cac aag cgg ggc acc gag atg gtc att acc aag tcg gga agg cga atg      919
His Lys Arg Gly Thr Glu Met Val Ile Thr Lys Ser Gly Arg Arg Met         
            120                 125                 130                 

ttt cct cca ttt aaa gtg aga tgt tct ggg ctg gat aaa aaa gcc aaa      967
Phe Pro Pro Phe Lys Val Arg Cys Ser Gly Leu Asp Lys Lys Ala Lys         
        135                 140                 145                     

tac att tta ttg atg gac att ata gct gct gat gac tgt cgt tat aaa     1015
Tyr Ile Leu Leu Met Asp Ile Ile Ala Ala Asp Asp Cys Arg Tyr Lys         
    150                 155                 160                         

ttt cac aat tct cgg tgg atg gtg gct ggt aag gcc gac ccc gaa atg     1063
Phe His Asn Ser Arg Trp Met Val Ala Gly Lys Ala Asp Pro Glu Met         
165                 170                 175                 180         

cca aag agg atg tac att cac ccg gac agc ccc gct act ggg gaa cag     1111
Pro Lys Arg Met Tyr Ile His Pro Asp Ser Pro Ala Thr Gly Glu Gln         
                185                 190                 195             

tgg atg tcc aaa gtc gtc act ttc cac aaa ctg aaa ctc acc aac aac     1159
Trp Met Ser Lys Val Val Thr Phe His Lys Leu Lys Leu Thr Asn Asn         
            200                 205                 210                 

att tca gac aaa cat gga ttt act ata ttg aac tcc atg cac aaa tac     1207
Ile Ser Asp Lys His Gly Phe Thr Ile Leu Asn Ser Met His Lys Tyr         
        215                 220                 225                     

cag ccc cgg ttc cac att gta aga gcc aat gac atc ttg aaa ctc cct     1255
Gln Pro Arg Phe His Ile Val Arg Ala Asn Asp Ile Leu Lys Leu Pro         
    230                 235                 240                         

tat agt aca ttt cgg aca tac ttg ttc ccc gaa act gaa ttc atc gct     1303
Tyr Ser Thr Phe Arg Thr Tyr Leu Phe Pro Glu Thr Glu Phe Ile Ala         
245                 250                 255                 260         

gtg act gca tac cag aat gat aag ata acc cag tta aaa ata gac aac     1351
Val Thr Ala Tyr Gln Asn Asp Lys Ile Thr Gln Leu Lys Ile Asp Asn         
                265                 270                 275             

aac cct ttt gca aaa ggt ttc cgg gac act gga aat ggc cga aga gaa     1399
Asn Pro Phe Ala Lys Gly Phe Arg Asp Thr Gly Asn Gly Arg Arg Glu         
            280                 285                 290                 

aaa aga aaa cag ctc acc ctg cag tcc atg agg gtg ttt gat gaa aga     1447
Lys Arg Lys Gln Leu Thr Leu Gln Ser Met Arg Val Phe Asp Glu Arg         
        295                 300                 305                     

cac aaa aag gag aat ggg acc tct gat gag tcc tcc agt gaa caa gca     1495
His Lys Lys Glu Asn Gly Thr Ser Asp Glu Ser Ser Ser Glu Gln Ala         
    310                 315                 320                         

gct ttc aac tgc ttc gcc cag gct tct tct cca gcc gcc tcc act gta     1543
Ala Phe Asn Cys Phe Ala Gln Ala Ser Ser Pro Ala Ala Ser Thr Val         
325                 330                 335                 340         

ggg aca tcg aac ctc aaa gat tta tgt ccc agc gag ggt gag agc gac     1591
Gly Thr Ser Asn Leu Lys Asp Leu Cys Pro Ser Glu Gly Glu Ser Asp         
                345                 350                 355             

gcc gag gcc gag agc aaa gag gag cat ggc ccc gag gcc tgc gac gcg     1639
Ala Glu Ala Glu Ser Lys Glu Glu His Gly Pro Glu Ala Cys Asp Ala         
            360                 365                 370                 

gcc aag atc tcc acc acc acg tcg gag gag ccc tgc cgt gac aag ggc     1687
Ala Lys Ile Ser Thr Thr Thr Ser Glu Glu Pro Cys Arg Asp Lys Gly         
        375                 380                 385                     

agc ccc gcg gtc aag gct cac ctt ttc gct gct gag cgg ccc cgg gac     1735
Ser Pro Ala Val Lys Ala His Leu Phe Ala Ala Glu Arg Pro Arg Asp         
    390                 395                 400                         

agc ggg cgg ctg gac aaa gcg tcg ccc gac tca cgc cat agc ccc gcc     1783
Ser Gly Arg Leu Asp Lys Ala Ser Pro Asp Ser Arg His Ser Pro Ala         
405                 410                 415                 420         

acc atc tcg tcc agc act cgc ggc ctg ggc gcg gag gag cgc agg agc     1831
Thr Ile Ser Ser Ser Thr Arg Gly Leu Gly Ala Glu Glu Arg Arg Ser         
                425                 430                 435             

ccg gtt cgc gag ggc aca gcg ccg gcc aag gtg gaa gag gcg cgc gcg     1879
Pro Val Arg Glu Gly Thr Ala Pro Ala Lys Val Glu Glu Ala Arg Ala         
            440                 445                 450                 

ctc ccg ggc aag gag gcc ttc gcg ccg ctc acg gtg cag acg gac gcg     1927
Leu Pro Gly Lys Glu Ala Phe Ala Pro Leu Thr Val Gln Thr Asp Ala         
        455                 460                 465                     

gcc gcc gcg cac ctg gcc cag ggc ccc ctg cct ggc ctc ggc ttc gcc     1975
Ala Ala Ala His Leu Ala Gln Gly Pro Leu Pro Gly Leu Gly Phe Ala         
    470                 475                 480                         

ccg ggc ctg gcg ggc caa cag ttc ttc aac ggg cac ccg ctc ttc ctg     2023
Pro Gly Leu Ala Gly Gln Gln Phe Phe Asn Gly His Pro Leu Phe Leu         
485                 490                 495                 500         

cac ccc agc cag ttt gcc atg ggg ggc gcc ttc tcc agc atg gcg gcc     2071
His Pro Ser Gln Phe Ala Met Gly Gly Ala Phe Ser Ser Met Ala Ala         
                505                 510                 515             

gct ggc atg ggt ccc ctc ctg gcc acg gtt tct ggg gcc tcc acc ggt     2119
Ala Gly Met Gly Pro Leu Leu Ala Thr Val Ser Gly Ala Ser Thr Gly         
            520                 525                 530                 

gtc tcg ggc ctg gat tcc acg gcc atg gcc tct gcc gct gcg gcg cag     2167
Val Ser Gly Leu Asp Ser Thr Ala Met Ala Ser Ala Ala Ala Ala Gln         
        535                 540                 545                     

gga ctg tcc ggg gcg tcc gcg gcc acc ctg ccc ttc cac ctc cag cag     2215
Gly Leu Ser Gly Ala Ser Ala Ala Thr Leu Pro Phe His Leu Gln Gln         
    550                 555                 560                         

cac gtc ctg gcc tct cag ggc ctg gcc atg tcc cct ttc gga agc ctg     2263
His Val Leu Ala Ser Gln Gly Leu Ala Met Ser Pro Phe Gly Ser Leu         
565                 570                 575                 580         

ttc cct tac ccc tac acg tac atg gcc gca gcg gcg gcc gcc tcc tct     2311
Phe Pro Tyr Pro Tyr Thr Tyr Met Ala Ala Ala Ala Ala Ala Ser Ser         
                585                 590                 595             

gcg gca gcc tcc agc tcg gtg cac cgc cac ccc ttc ctc aat ctg aac     2359
Ala Ala Ala Ser Ser Ser Val His Arg His Pro Phe Leu Asn Leu Asn         
            600                 605                 610                 

acc atg cgc ccg cgg ctg cgc tac agc ccc tac tcc atc ccg gtg ccg     2407
Thr Met Arg Pro Arg Leu Arg Tyr Ser Pro Tyr Ser Ile Pro Val Pro         
        615                 620                 625                     

gtc ccg gac ggc agc agt ctg ctc acc acc gcc ctg ccc tcc atg gcg     2455
Val Pro Asp Gly Ser Ser Leu Leu Thr Thr Ala Leu Pro Ser Met Ala         
    630                 635                 640                         

gcg gcc gcg ggg ccc ctg gac ggc aaa gtc gcc gcc ctg gcc gcc agc     2503
Ala Ala Ala Gly Pro Leu Asp Gly Lys Val Ala Ala Leu Ala Ala Ser         
645                 650                 655                 660         

ccg gcc tcg gtg gca gtg gac tcg ggc tct gaa ctc aac agc cgc tcc     2551
Pro Ala Ser Val Ala Val Asp Ser Gly Ser Glu Leu Asn Ser Arg Ser         
                665                 670                 675             

tcc acg ctc tcc tcc agc tcc atg tcc ttg tcg ccc aaa ctc tgc gcg     2599
Ser Thr Leu Ser Ser Ser Ser Met Ser Leu Ser Pro Lys Leu Cys Ala         
            680                 685                 690                 

gag aaa gag gcg gcc acc agc gaa ctg cag agc atc cag cgg ttg gtt     2647
Glu Lys Glu Ala Ala Thr Ser Glu Leu Gln Ser Ile Gln Arg Leu Val         
        695                 700                 705                     

agc ggc ttg gaa gcc aag ccg gac agg tcc cgc agc gcg tcc ccg tag     2695
Ser Gly Leu Glu Ala Lys Pro Asp Arg Ser Arg Ser Ala Ser Pro             
    710                 715                 720                         

acccgtccca gacacgtctt ttcattccag tccagttcag gctgccgtgc actttgtcgg   2755

atataaaata aaccacgggc ccgccatggc gttagccctt ccttttgcag ttgcgtctgg   2815

gaaggggccc cggactccct cgagagaatg tgctagagac agcccctgtc ttcttggcgt   2875

ggtttatatg tccgggatct ggatcagatt ctgggggctc agaaacgtcg gttgcattga   2935

gctactgggg gtaggagttc caacatttat gtccagagca acttccagca aggctggtct   2995

gggtctctgc ccaccaggcg gggaggtgtt caaagacatc tccctcagtg cggatttata   3055

tatatatttt tccttcactg tgtcaagtgg aaacaaaaac aaaaaaaaaa aaaaaaaa     3113


<210>  54
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ser Leu Ser Met Arg Asp Pro Val Ile Pro Gly Thr Ser Met Ala 
1               5                   10                  15      


Tyr His Pro Phe Leu Pro His Arg Ala Pro Asp Phe Ala Met Ser Ala 
            20                  25                  30          


Val Leu Gly His Gln Pro Pro Phe Phe Pro Ala Leu Thr Leu Pro Pro 
        35                  40                  45              


Asn Gly Ala Ala Ala Leu Ser Leu Pro Gly Ala Leu Ala Lys Pro Ile 
    50                  55                  60                  


Met Asp Gln Leu Val Gly Ala Ala Glu Thr Gly Ile Pro Phe Ser Ser 
65                  70                  75                  80  


Leu Gly Pro Gln Ala His Leu Arg Pro Leu Lys Thr Met Glu Pro Glu 
                85                  90                  95      


Glu Glu Val Glu Asp Asp Pro Lys Val His Leu Glu Ala Lys Glu Leu 
            100                 105                 110         


Trp Asp Gln Phe His Lys Arg Gly Thr Glu Met Val Ile Thr Lys Ser 
        115                 120                 125             


Gly Arg Arg Met Phe Pro Pro Phe Lys Val Arg Cys Ser Gly Leu Asp 
    130                 135                 140                 


Lys Lys Ala Lys Tyr Ile Leu Leu Met Asp Ile Ile Ala Ala Asp Asp 
145                 150                 155                 160 


Cys Arg Tyr Lys Phe His Asn Ser Arg Trp Met Val Ala Gly Lys Ala 
                165                 170                 175     


Asp Pro Glu Met Pro Lys Arg Met Tyr Ile His Pro Asp Ser Pro Ala 
            180                 185                 190         


Thr Gly Glu Gln Trp Met Ser Lys Val Val Thr Phe His Lys Leu Lys 
        195                 200                 205             


Leu Thr Asn Asn Ile Ser Asp Lys His Gly Phe Thr Ile Leu Asn Ser 
    210                 215                 220                 


Met His Lys Tyr Gln Pro Arg Phe His Ile Val Arg Ala Asn Asp Ile 
225                 230                 235                 240 


Leu Lys Leu Pro Tyr Ser Thr Phe Arg Thr Tyr Leu Phe Pro Glu Thr 
                245                 250                 255     


Glu Phe Ile Ala Val Thr Ala Tyr Gln Asn Asp Lys Ile Thr Gln Leu 
            260                 265                 270         


Lys Ile Asp Asn Asn Pro Phe Ala Lys Gly Phe Arg Asp Thr Gly Asn 
        275                 280                 285             


Gly Arg Arg Glu Lys Arg Lys Gln Leu Thr Leu Gln Ser Met Arg Val 
    290                 295                 300                 


Phe Asp Glu Arg His Lys Lys Glu Asn Gly Thr Ser Asp Glu Ser Ser 
305                 310                 315                 320 


Ser Glu Gln Ala Ala Phe Asn Cys Phe Ala Gln Ala Ser Ser Pro Ala 
                325                 330                 335     


Ala Ser Thr Val Gly Thr Ser Asn Leu Lys Asp Leu Cys Pro Ser Glu 
            340                 345                 350         


Gly Glu Ser Asp Ala Glu Ala Glu Ser Lys Glu Glu His Gly Pro Glu 
        355                 360                 365             


Ala Cys Asp Ala Ala Lys Ile Ser Thr Thr Thr Ser Glu Glu Pro Cys 
    370                 375                 380                 


Arg Asp Lys Gly Ser Pro Ala Val Lys Ala His Leu Phe Ala Ala Glu 
385                 390                 395                 400 


Arg Pro Arg Asp Ser Gly Arg Leu Asp Lys Ala Ser Pro Asp Ser Arg 
                405                 410                 415     


His Ser Pro Ala Thr Ile Ser Ser Ser Thr Arg Gly Leu Gly Ala Glu 
            420                 425                 430         


Glu Arg Arg Ser Pro Val Arg Glu Gly Thr Ala Pro Ala Lys Val Glu 
        435                 440                 445             


Glu Ala Arg Ala Leu Pro Gly Lys Glu Ala Phe Ala Pro Leu Thr Val 
    450                 455                 460                 


Gln Thr Asp Ala Ala Ala Ala His Leu Ala Gln Gly Pro Leu Pro Gly 
465                 470                 475                 480 


Leu Gly Phe Ala Pro Gly Leu Ala Gly Gln Gln Phe Phe Asn Gly His 
                485                 490                 495     


Pro Leu Phe Leu His Pro Ser Gln Phe Ala Met Gly Gly Ala Phe Ser 
            500                 505                 510         


Ser Met Ala Ala Ala Gly Met Gly Pro Leu Leu Ala Thr Val Ser Gly 
        515                 520                 525             


Ala Ser Thr Gly Val Ser Gly Leu Asp Ser Thr Ala Met Ala Ser Ala 
    530                 535                 540                 


Ala Ala Ala Gln Gly Leu Ser Gly Ala Ser Ala Ala Thr Leu Pro Phe 
545                 550                 555                 560 


His Leu Gln Gln His Val Leu Ala Ser Gln Gly Leu Ala Met Ser Pro 
                565                 570                 575     


Phe Gly Ser Leu Phe Pro Tyr Pro Tyr Thr Tyr Met Ala Ala Ala Ala 
            580                 585                 590         


Ala Ala Ser Ser Ala Ala Ala Ser Ser Ser Val His Arg His Pro Phe 
        595                 600                 605             


Leu Asn Leu Asn Thr Met Arg Pro Arg Leu Arg Tyr Ser Pro Tyr Ser 
    610                 615                 620                 


Ile Pro Val Pro Val Pro Asp Gly Ser Ser Leu Leu Thr Thr Ala Leu 
625                 630                 635                 640 


Pro Ser Met Ala Ala Ala Ala Gly Pro Leu Asp Gly Lys Val Ala Ala 
                645                 650                 655     


Leu Ala Ala Ser Pro Ala Ser Val Ala Val Asp Ser Gly Ser Glu Leu 
            660                 665                 670         


Asn Ser Arg Ser Ser Thr Leu Ser Ser Ser Ser Met Ser Leu Ser Pro 
        675                 680                 685             


Lys Leu Cys Ala Glu Lys Glu Ala Ala Thr Ser Glu Leu Gln Ser Ile 
    690                 695                 700                 


Gln Arg Leu Val Ser Gly Leu Glu Ala Lys Pro Asp Arg Ser Arg Ser 
705                 710                 715                 720 


Ala Ser Pro 
            


<210>  55
<211>  2727
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (197)..(535)
<223>  

<400>  55
cgggccggcc tggtgctgca cgcctgtcag ccatcgcccg agccgccggc gtctcctccc     60

gcccagcagt tcctccacgc aggggctccg gaatcgcccg accgcacacg ttgccaccct    120

gaggtctttt tggaagtgga tatctactca gacagtaaga attataagag ctgtaagagc    180

tcattttgga ggaata atg gat gaa cca tct ccc ttg gcc caa cct ctg gag    232
                  Met Asp Glu Pro Ser Pro Leu Ala Gln Pro Leu Glu       
                  1               5                   10                

ctg aac cag cac tct cga ttc ata ata ggt tct gtg tct gaa gat aac      280
Leu Asn Gln His Ser Arg Phe Ile Ile Gly Ser Val Ser Glu Asp Asn         
        15                  20                  25                      

tca gag gat gag atc agc aac ctg gtg aag ttg gac cta ctg gag gag      328
Ser Glu Asp Glu Ile Ser Asn Leu Val Lys Leu Asp Leu Leu Glu Glu         
    30                  35                  40                          

aag gag ggc tcc ttg tca cct gct tct gtt ggc tca gat aca ctc tct      376
Lys Glu Gly Ser Leu Ser Pro Ala Ser Val Gly Ser Asp Thr Leu Ser         
45                  50                  55                  60          

gat ttg ggg atc tct agc cta cag gat ggc ttg gcc ttg cac ata agt      424
Asp Leu Gly Ile Ser Ser Leu Gln Asp Gly Leu Ala Leu His Ile Ser         
                65                  70                  75              

tct tgg att aaa agg tct gga tca gtg gtt ctt ggt tct cac tgt tca      472
Ser Trp Ile Lys Arg Ser Gly Ser Val Val Leu Gly Ser His Cys Ser         
            80                  85                  90                  

tca gaa tca cct cgg gga gcc ttg gga gat aag ccc cat ccc cag aga      520
Ser Glu Ser Pro Arg Gly Ala Leu Gly Asp Lys Pro His Pro Gln Arg         
        95                  100                 105                     

ttt cga ttc att tga tactggcttg gtgtggaact ggggcttttt tttaagggac      575
Phe Arg Phe Ile                                                         
    110                                                                 

agagtcttac catgttgccc aggctggttt cgaactcctg gcctcaagtg accttcttgc    635

cttggcctcc caaatctctg gaattacagg ctccaaagat ctgcctttcc ccttccactc    695

tgtgaggaca caatgagaat catgcaagcg agtaggacct ggaggcaggg aacccaagaa    755

ctttctagaa ctaaatcaaa tggaaacaag cacttcagtt atgacaggaa gcatcctctt    815

cctttacata ggatatacac tgaataaatg actttgtaac ttcatcatct ttatttacac    875

agggtgtata ccaagtaaca atggaaatct ctagagggta tttaaacccc agaaaattct    935

gtaaccagac ccttgagtgg ctggcttgct tgggccagct cccaacctgt agagtgtgct    995

ttcattttct tttttttatt ttttatttta attttttgat tttttgaaat ggagtctcgc   1055

cctttagccc aggctggagt gcagtggtgc gatcttggct cattgaaacc tttgcctccc   1115

gggttcaagc aattctcatg cctcagcctc ccgagtagct gggactatag gtgcccacca   1175

ccacgcccag ctaatttttt gtatttttta gtagagatgg ggtttcactg tgttagccag   1235

gatggtcttg atctcctgac ctcgtgatcc acccgcctca gcctcccaat gtgttgggat   1295

tacaggtgtg agccaccgtg cctggcctaa tttttgtatt tttagtagag acaacgtttc   1355

aacatgttgg ctaggctggt ctcgaactcc tgacctcatg ttatcccccc acatttacct   1415

cccaaagtgc tggaattaca gacatgagcc actgtgcctg gccgtgtgct ttcattttca   1475

gttaagtctc tgcttttgtt gctttattct ttccctgctt tgtttgtgtg ttttgttcaa   1535

ttctttgttc aaaacaccaa gaacttgtac agcctccact ggtaacatat tttggcaagc   1595

cagccaggag gtaatcccaa agtttggggt ttatttttct tgtttgtttt tcctgctcca   1655

tacaggggaa tctcagtctc tctctctctt ttcctttcca acttgggacg gttggtgggc   1715

agcacctaaa cacagaggca actgcaggtt tctggccggg gccactctga aggactcctt   1775

tctatctttt ccagttgtgg tccctgatcc ctacgtgtgg cacagcttgg ggcgagctgg   1835

catttgtttc agtgacttaa accttgtttt ctcatgctaa attcttccct tcccctactc   1895

tactggctaa ggacaaaaga aacccaccca gcctccagtt cctatcatta cagttcatgg   1955

ctatcactct agtggaacag gaagcatggg aaagtgtggc cttatcaaat tataaggatg   2015

ccagaagtcc aggccttcat ccagggacaa aaggaaacct catagtaggc cattgcctct   2075

gaagggaaaa catgctaagc agcaccagtg cccacctaag gtcagagacg tctgacactc   2135

tgagactgga ccccaaaggg ggacggccca gggatcctcc agacctcaac ttctccaaag   2195

gggacaccct aggcagagtt ctgaggtcta gtattaagcc ctccttagaa ttttctctcg   2255

cagttgcaat actgtttggc ccaatattgt ttggaatctg gagcttgctg ttgaatggga   2315

aagtgggatg gagttgcatg tgtcaaactg ctgtggaaac tgctatatct gaaattttgg   2375

ttcacagcct tcattggatt atctgttggg gcaaacaaag gaaaaccccc caagcttgta   2435

ttgctatctc atgccttaag attcccagtt aaaagcgatt gaatcttcgt ttgtgtgcgt   2495

ctatacatgt ctagatgtgt ttatttgtat gcacacttat tgttacatgt tgtgtctacc   2555

aaattggctt ataaataaaa gagcacttaa aaattaagta aataagtcta agcaattttc   2615

aagttcacgt gacttaagta taactttact aaacaagctg gctttaaaat tattagtaaa   2675

ataaaactag aaatgccttc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa           2727


<210>  56
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Asp Glu Pro Ser Pro Leu Ala Gln Pro Leu Glu Leu Asn Gln His 
1               5                   10                  15      


Ser Arg Phe Ile Ile Gly Ser Val Ser Glu Asp Asn Ser Glu Asp Glu 
            20                  25                  30          


Ile Ser Asn Leu Val Lys Leu Asp Leu Leu Glu Glu Lys Glu Gly Ser 
        35                  40                  45              


Leu Ser Pro Ala Ser Val Gly Ser Asp Thr Leu Ser Asp Leu Gly Ile 
    50                  55                  60                  


Ser Ser Leu Gln Asp Gly Leu Ala Leu His Ile Ser Ser Trp Ile Lys 
65                  70                  75                  80  


Arg Ser Gly Ser Val Val Leu Gly Ser His Cys Ser Ser Glu Ser Pro 
                85                  90                  95      


Arg Gly Ala Leu Gly Asp Lys Pro His Pro Gln Arg Phe Arg Phe Ile 
            100                 105                 110         


<210>  57
<211>  593
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (13)..(369)
<223>  

<400>  57
gcttggtgcg ct atg gcg aca ccc agc ctg cgg ggt cgt ctg gcg cgg ttt     51
              Met Ala Thr Pro Ser Leu Arg Gly Arg Leu Ala Arg Phe       
              1               5                   10                    

ggg aac ccg cgg aag cct gtg ctg aag ccc aat aaa cct ctc att cta       99
Gly Asn Pro Arg Lys Pro Val Leu Lys Pro Asn Lys Pro Leu Ile Leu         
    15                  20                  25                          

gct aac cgc gtc ggg gag cgg cgc cgg gag aag ggc gag gcg act tgc      147
Ala Asn Arg Val Gly Glu Arg Arg Arg Glu Lys Gly Glu Ala Thr Cys         
30                  35                  40                  45          

atc acg gag atg tcg gtg atg atg gct tgc tgg aag cag aat gaa ttc      195
Ile Thr Glu Met Ser Val Met Met Ala Cys Trp Lys Gln Asn Glu Phe         
                50                  55                  60              

cgc gac gat gcg tgc aga aaa gag atc cag ggc ttc ctc gat tgt gcc      243
Arg Asp Asp Ala Cys Arg Lys Glu Ile Gln Gly Phe Leu Asp Cys Ala         
            65                  70                  75                  

gcg agg gct cag gaa gcc cga aag atg aga tca ata cag gaa acc ctg      291
Ala Arg Ala Gln Glu Ala Arg Lys Met Arg Ser Ile Gln Glu Thr Leu         
        80                  85                  90                      

gga gag tct ggg agt tta ctt cca aat aaa ttg aat aag ttg tta cag      339
Gly Glu Ser Gly Ser Leu Leu Pro Asn Lys Leu Asn Lys Leu Leu Gln         
    95                  100                 105                         

agg ttt cct aac aaa cct tac ctc agc tga aaatggacaa gtattttcaa        389
Arg Phe Pro Asn Lys Pro Tyr Leu Ser                                     
110                 115                                                 

tgactgaaat atagcttctg acaactatgc agaggcattt tagagacatt ggcattgcca    449

tgccctcttt ggagggtaga agaggcaaaa cacttttttc accctttgga atcatagtat    509

gggtagaagt tatgatttat cttgaaataa aatcctctga acagaaaaaa aaaaaaaaaa    569

aaaaaaaaaa aaaaaaaaaa aaaa                                           593


<210>  58
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Thr Pro Ser Leu Arg Gly Arg Leu Ala Arg Phe Gly Asn Pro 
1               5                   10                  15      


Arg Lys Pro Val Leu Lys Pro Asn Lys Pro Leu Ile Leu Ala Asn Arg 
            20                  25                  30          


Val Gly Glu Arg Arg Arg Glu Lys Gly Glu Ala Thr Cys Ile Thr Glu 
        35                  40                  45              


Met Ser Val Met Met Ala Cys Trp Lys Gln Asn Glu Phe Arg Asp Asp 
    50                  55                  60                  


Ala Cys Arg Lys Glu Ile Gln Gly Phe Leu Asp Cys Ala Ala Arg Ala 
65                  70                  75                  80  


Gln Glu Ala Arg Lys Met Arg Ser Ile Gln Glu Thr Leu Gly Glu Ser 
                85                  90                  95      


Gly Ser Leu Leu Pro Asn Lys Leu Asn Lys Leu Leu Gln Arg Phe Pro 
            100                 105                 110         


Asn Lys Pro Tyr Leu Ser 
        115             


<210>  59
<211>  3860
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (45)..(2486)
<223>  

<400>  59
gaattcccta aagaattaga agtgcgtctc accaaccagc caag atg aac atg gtg      56
                                                 Met Asn Met Val        
                                                 1                      

aag agg atc atg ggg cgg ccg agg cag gag gag tgc agc cca caa gac      104
Lys Arg Ile Met Gly Arg Pro Arg Gln Glu Glu Cys Ser Pro Gln Asp         
5                   10                  15                  20          

aac gcc tta gga ctg atg cac ctc cgc cgg ctc ttc acg gag ttg tgc      152
Asn Ala Leu Gly Leu Met His Leu Arg Arg Leu Phe Thr Glu Leu Cys         
                25                  30                  35              

cat cct ccc cgg cac atg act cag aag gaa caa gaa gag aaa ctg tat      200
His Pro Pro Arg His Met Thr Gln Lys Glu Gln Glu Glu Lys Leu Tyr         
            40                  45                  50                  

atg atg ctg cca gtg ttt aac agg gtt ttt gga aat gct ccg ccg aat      248
Met Met Leu Pro Val Phe Asn Arg Val Phe Gly Asn Ala Pro Pro Asn         
        55                  60                  65                      

aca atg aca gaa aaa ttt tct gat ctt ctg cag ttc aca aca caa gtc      296
Thr Met Thr Glu Lys Phe Ser Asp Leu Leu Gln Phe Thr Thr Gln Val         
    70                  75                  80                          

tca cga cta atg gtg aca gaa att cga agg aga gca tca aac aaa tcc      344
Ser Arg Leu Met Val Thr Glu Ile Arg Arg Arg Ala Ser Asn Lys Ser         
85                  90                  95                  100         

aca gaa aaa cag tgt gcc ctg ctg tcc ccc aag gat ttc aaa gcc aca      392
Thr Glu Lys Gln Cys Ala Leu Leu Ser Pro Lys Asp Phe Lys Ala Thr         
                105                 110                 115             

aca cct tca gag gct gca agt cgg gcc ata gtt cag ttc cta gag att      440
Thr Pro Ser Glu Ala Ala Ser Arg Ala Ile Val Gln Phe Leu Glu Ile         
            120                 125                 130                 

aat cag agt gaa gaa gcc agt aga ggc tgg atg ctt cta acg aca att      488
Asn Gln Ser Glu Glu Ala Ser Arg Gly Trp Met Leu Leu Thr Thr Ile         
        135                 140                 145                     

aat ttg tta gct tcc tct ggt cag aaa acc gtg gac tgc atg aca aca      536
Asn Leu Leu Ala Ser Ser Gly Gln Lys Thr Val Asp Cys Met Thr Thr         
    150                 155                 160                         

atg tca gtg cct tcc acc ctg gtt aaa tgt tta tat ctg ttt ttt gac      584
Met Ser Val Pro Ser Thr Leu Val Lys Cys Leu Tyr Leu Phe Phe Asp         
165                 170                 175                 180         

ctt cca cat gtg cct gag gca gtt gga ggt gca cag aat gag cta cct      632
Leu Pro His Val Pro Glu Ala Val Gly Gly Ala Gln Asn Glu Leu Pro         
                185                 190                 195             

cta gca gaa cgt cga gga cta ctc cag aaa gtt ttt gta cag atc tta      680
Leu Ala Glu Arg Arg Gly Leu Leu Gln Lys Val Phe Val Gln Ile Leu         
            200                 205                 210                 

gtg aaa ctg tgc agt ttt gtt tcc cct gcg gag gag ctg gct cag aaa      728
Val Lys Leu Cys Ser Phe Val Ser Pro Ala Glu Glu Leu Ala Gln Lys         
        215                 220                 225                     

gat gat ctc cag ctt cta ttc agt gca ata acc tct tgg tgc cct ccc      776
Asp Asp Leu Gln Leu Leu Phe Ser Ala Ile Thr Ser Trp Cys Pro Pro         
    230                 235                 240                         

tat aac ctg cct tgg aga aag agt gct gga gaa gtc ctc atg acc ata      824
Tyr Asn Leu Pro Trp Arg Lys Ser Ala Gly Glu Val Leu Met Thr Ile         
245                 250                 255                 260         

tct cgt cat ggt ctt agt gtc aat gta gtg aag tat att cat gag aaa      872
Ser Arg His Gly Leu Ser Val Asn Val Val Lys Tyr Ile His Glu Lys         
                265                 270                 275             

gag tgt tta tct aca tgt gtt cag aat atg cag caa tca gat gac ctg      920
Glu Cys Leu Ser Thr Cys Val Gln Asn Met Gln Gln Ser Asp Asp Leu         
            280                 285                 290                 

tct ccc cta gaa att gtc gaa atg ttt gct ggg ctt tct tgt ttc ctc      968
Ser Pro Leu Glu Ile Val Glu Met Phe Ala Gly Leu Ser Cys Phe Leu         
        295                 300                 305                     

aaa gat tcc agc gat gtt tcc caa aca ctt ctg gat gat ttt cgg ata     1016
Lys Asp Ser Ser Asp Val Ser Gln Thr Leu Leu Asp Asp Phe Arg Ile         
    310                 315                 320                         

tgg caa gga tat aat ttt ctt tgt gat ctc ttg ctt aga ttg gaa caa     1064
Trp Gln Gly Tyr Asn Phe Leu Cys Asp Leu Leu Leu Arg Leu Glu Gln         
325                 330                 335                 340         

gca aaa gag gca gaa tcc aaa gat gcc ttg aaa gat ctg gtt aat ctg     1112
Ala Lys Glu Ala Glu Ser Lys Asp Ala Leu Lys Asp Leu Val Asn Leu         
                345                 350                 355             

ata act tcc cta aca aca tat ggt gtc agt gaa cta aaa cca gct ggt     1160
Ile Thr Ser Leu Thr Thr Tyr Gly Val Ser Glu Leu Lys Pro Ala Gly         
            360                 365                 370                 

att acc aca ggg gca ccc ttt tta ttg cct gga ttt gca gta cct cag     1208
Ile Thr Thr Gly Ala Pro Phe Leu Leu Pro Gly Phe Ala Val Pro Gln         
        375                 380                 385                     

cct gca ggc aaa ggt cac agt gtg aga aac gtc cag gcc ttt gca gtt     1256
Pro Ala Gly Lys Gly His Ser Val Arg Asn Val Gln Ala Phe Ala Val         
    390                 395                 400                         

ctt cag aat gca ttt tta aaa gca aaa acc agc ttc ctt gcc caa atc     1304
Leu Gln Asn Ala Phe Leu Lys Ala Lys Thr Ser Phe Leu Ala Gln Ile         
405                 410                 415                 420         

atc ctt gat gct atc aca aat att tac atg gct gac aat gcc aat tac     1352
Ile Leu Asp Ala Ile Thr Asn Ile Tyr Met Ala Asp Asn Ala Asn Tyr         
                425                 430                 435             

ttc atc cta gag tca cag cac aca ttg tca cag ttt gca gag aag att     1400
Phe Ile Leu Glu Ser Gln His Thr Leu Ser Gln Phe Ala Glu Lys Ile         
            440                 445                 450                 

tct aaa ctc cca gaa gta caa aac aaa tac ttt gag atg ctg gag ttt     1448
Ser Lys Leu Pro Glu Val Gln Asn Lys Tyr Phe Glu Met Leu Glu Phe         
        455                 460                 465                     

gtt gtt ttt agc tta aat tat ata cct tgt aaa gaa ctt att agt gtc     1496
Val Val Phe Ser Leu Asn Tyr Ile Pro Cys Lys Glu Leu Ile Ser Val         
    470                 475                 480                         

agt atc ctc tta aaa tct agc tct tct tat cac tgt agc att att gca     1544
Ser Ile Leu Leu Lys Ser Ser Ser Ser Tyr His Cys Ser Ile Ile Ala         
485                 490                 495                 500         

atg aaa aca ctt ctt aag ttt aca aga cat gac tac ata ttt aaa gac     1592
Met Lys Thr Leu Leu Lys Phe Thr Arg His Asp Tyr Ile Phe Lys Asp         
                505                 510                 515             

gtg ttc agg gag gtt ggc ctt ttg gag gtc atg gta aac ctt ttg cat     1640
Val Phe Arg Glu Val Gly Leu Leu Glu Val Met Val Asn Leu Leu His         
            520                 525                 530                 

aaa tat gct gcc ctg ttg aag gat cca act cag gca cta aat gaa caa     1688
Lys Tyr Ala Ala Leu Leu Lys Asp Pro Thr Gln Ala Leu Asn Glu Gln         
        535                 540                 545                     

ggg gac tca aga aat aat agt tca gtt gaa gac caa aaa cac ctg gct     1736
Gly Asp Ser Arg Asn Asn Ser Ser Val Glu Asp Gln Lys His Leu Ala         
    550                 555                 560                         

tta ttg gtt atg gag acc ttg aca gtg ctt ctt caa gga tca aac aca     1784
Leu Leu Val Met Glu Thr Leu Thr Val Leu Leu Gln Gly Ser Asn Thr         
565                 570                 575                 580         

aat gca gga att ttt cga gaa ttt gga ggt gca aga tgt gca cat aat     1832
Asn Ala Gly Ile Phe Arg Glu Phe Gly Gly Ala Arg Cys Ala His Asn         
                585                 590                 595             

ata gta aag tac cct caa tgc cgg cag cat gcc ttg atg act atc caa     1880
Ile Val Lys Tyr Pro Gln Cys Arg Gln His Ala Leu Met Thr Ile Gln         
            600                 605                 610                 

cag ctg gtg ctc tcc cca aat ggg gac gat gac atg ggc act ctc ctg     1928
Gln Leu Val Leu Ser Pro Asn Gly Asp Asp Asp Met Gly Thr Leu Leu         
        615                 620                 625                     

ggg cta atg cat tca gcc cca ccg acg gaa ttg cag ttg aag act gat     1976
Gly Leu Met His Ser Ala Pro Pro Thr Glu Leu Gln Leu Lys Thr Asp         
    630                 635                 640                         

att tta agg gcc ctc ctg tcg gtc ctt cga gaa agc cat cgt tca aga     2024
Ile Leu Arg Ala Leu Leu Ser Val Leu Arg Glu Ser His Arg Ser Arg         
645                 650                 655                 660         

aca gtt ttt agg aaa gtt gga gga ttt gtg tac att aca tcc ttg ctc     2072
Thr Val Phe Arg Lys Val Gly Gly Phe Val Tyr Ile Thr Ser Leu Leu         
                665                 670                 675             

gtt gct atg gaa aga tct ttg agc tgt cca ccc aag aat ggc tgg gag     2120
Val Ala Met Glu Arg Ser Leu Ser Cys Pro Pro Lys Asn Gly Trp Glu         
            680                 685                 690                 

aaa gtg aac cag aat caa gtg ttt gaa ctt ctt cac act gtg ttc tgc     2168
Lys Val Asn Gln Asn Gln Val Phe Glu Leu Leu His Thr Val Phe Cys         
        695                 700                 705                     

acg ttg act gca gca atg cgc tat gag cca gcc aac tct cat ttc ttc     2216
Thr Leu Thr Ala Ala Met Arg Tyr Glu Pro Ala Asn Ser His Phe Phe         
    710                 715                 720                         

aaa aca gag att cag tat gag aag ttg gca gat gct gtt cga ttt ctt     2264
Lys Thr Glu Ile Gln Tyr Glu Lys Leu Ala Asp Ala Val Arg Phe Leu         
725                 730                 735                 740         

ggc tgc ttc tca gac cta aga aaa ata agc gcc atg aat gtc ttc ccc     2312
Gly Cys Phe Ser Asp Leu Arg Lys Ile Ser Ala Met Asn Val Phe Pro         
                745                 750                 755             

tca aat aca cag cca ttt caa aga ctt tta gag gaa gat gta atc tca     2360
Ser Asn Thr Gln Pro Phe Gln Arg Leu Leu Glu Glu Asp Val Ile Ser         
            760                 765                 770                 

ata gaa tca gtg tca ccc acg tta cgg cac tgc agt aaa ctt ttt att     2408
Ile Glu Ser Val Ser Pro Thr Leu Arg His Cys Ser Lys Leu Phe Ile         
        775                 780                 785                     

tat ctt tac aaa gta gcc aca gat tct ttt gac agg tat ggc tct gct     2456
Tyr Leu Tyr Lys Val Ala Thr Asp Ser Phe Asp Arg Tyr Gly Ser Ala         
    790                 795                 800                         

ctg tcc tct gaa tta aag ggt gta tac taa gcatgacttc aacattaaga       2506
Leu Ser Ser Glu Leu Lys Gly Val Tyr                                     
805                 810                                                 

cttgaattat gagttaatcc aaaagaatat gaaaacagat gactcttctc ctatttgttt   2566

gaagtgtatc actttatttt tgaatattac tcttgctctg gtattgtttt tttttttttt   2626

ttagcatgga agcctgtgta ctatttgtaa attcaggttc aattagttct cattgcagtt   2686

attggaacag tttctatgaa gtttccttta atgatagtgt ttactgttgt tttttttctt   2746

tttagcctca aaaggtgcat ctggacttat tgatatgtgt tatcaataga acatcattat   2806

gattattctt atttccagac acgtactcca tcattctcca catatcatac tcctcaaaaa   2866

atgatatagt tcccaaagag aggtgtcagt gtcttgaacc gtcaagttca agaggccatc   2926

agactcaata tttactcatt ccttcatgaa ataagtactt aacaaaaagc tgctgcatgc   2986

caagtcactg tgctaggcat tgaggattca gctctacaca gggctgtctt ggtccttgct   3046

atcttttagc taaaatgtag acacataaat aaacaattac atatagtgtg acacattcta   3106

cagtggggga atccagggtt ctcaggcaga ttgtaggaga gccacttcat ctagatcact   3166

tattttcagt gcttcaactg tgttttcaat gaagatgtca ctttgaaaat aatacttcta   3226

atttatgccc caagtgttat tgcttttaac ttaccatagt tttactacat aaaataaatg   3286

aactgccctc atcaatagac catgtaacta cattggatag agcttgtaat aggttttgtg   3346

tccttttctg tggaatatct gctttgaagt atcaactgag atatttcctg cttcttaaca   3406

agatttctta gtcctcagta tttacattta aaaatccaaa cagctttgac aacaattgta   3466

aaaaaaaaaa tcattaaact tctgcttttc cctatcttga agtaaaatgc atatgtatag   3526

ttaatttatc gaaaacacag gacagtgtag tgttctagga atgagctata taaatttgtg   3586

tattcagatt caacctcttt tcccttgatt tctacttatc ctagttagaa tacatcattt   3646

ttagtcactg tcaaaaatag ggcttagagc accctgttta acagatgtgt taaatgttaa   3706

catgaatgga ataagcatct gccgtgagca tgcttttctg tttcattcag tgcttgtgtt   3766

gtagtcttgt tccttgttcc tgctgaatat ggaagatgtt ccttattaaa cttttactgg   3826

catttcttgt gaaactaaaa aaaaaaaaaa aaaa                               3860


<210>  60
<211>  813
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Asn Met Val Lys Arg Ile Met Gly Arg Pro Arg Gln Glu Glu Cys 
1               5                   10                  15      


Ser Pro Gln Asp Asn Ala Leu Gly Leu Met His Leu Arg Arg Leu Phe 
            20                  25                  30          


Thr Glu Leu Cys His Pro Pro Arg His Met Thr Gln Lys Glu Gln Glu 
        35                  40                  45              


Glu Lys Leu Tyr Met Met Leu Pro Val Phe Asn Arg Val Phe Gly Asn 
    50                  55                  60                  


Ala Pro Pro Asn Thr Met Thr Glu Lys Phe Ser Asp Leu Leu Gln Phe 
65                  70                  75                  80  


Thr Thr Gln Val Ser Arg Leu Met Val Thr Glu Ile Arg Arg Arg Ala 
                85                  90                  95      


Ser Asn Lys Ser Thr Glu Lys Gln Cys Ala Leu Leu Ser Pro Lys Asp 
            100                 105                 110         


Phe Lys Ala Thr Thr Pro Ser Glu Ala Ala Ser Arg Ala Ile Val Gln 
        115                 120                 125             


Phe Leu Glu Ile Asn Gln Ser Glu Glu Ala Ser Arg Gly Trp Met Leu 
    130                 135                 140                 


Leu Thr Thr Ile Asn Leu Leu Ala Ser Ser Gly Gln Lys Thr Val Asp 
145                 150                 155                 160 


Cys Met Thr Thr Met Ser Val Pro Ser Thr Leu Val Lys Cys Leu Tyr 
                165                 170                 175     


Leu Phe Phe Asp Leu Pro His Val Pro Glu Ala Val Gly Gly Ala Gln 
            180                 185                 190         


Asn Glu Leu Pro Leu Ala Glu Arg Arg Gly Leu Leu Gln Lys Val Phe 
        195                 200                 205             


Val Gln Ile Leu Val Lys Leu Cys Ser Phe Val Ser Pro Ala Glu Glu 
    210                 215                 220                 


Leu Ala Gln Lys Asp Asp Leu Gln Leu Leu Phe Ser Ala Ile Thr Ser 
225                 230                 235                 240 


Trp Cys Pro Pro Tyr Asn Leu Pro Trp Arg Lys Ser Ala Gly Glu Val 
                245                 250                 255     


Leu Met Thr Ile Ser Arg His Gly Leu Ser Val Asn Val Val Lys Tyr 
            260                 265                 270         


Ile His Glu Lys Glu Cys Leu Ser Thr Cys Val Gln Asn Met Gln Gln 
        275                 280                 285             


Ser Asp Asp Leu Ser Pro Leu Glu Ile Val Glu Met Phe Ala Gly Leu 
    290                 295                 300                 


Ser Cys Phe Leu Lys Asp Ser Ser Asp Val Ser Gln Thr Leu Leu Asp 
305                 310                 315                 320 


Asp Phe Arg Ile Trp Gln Gly Tyr Asn Phe Leu Cys Asp Leu Leu Leu 
                325                 330                 335     


Arg Leu Glu Gln Ala Lys Glu Ala Glu Ser Lys Asp Ala Leu Lys Asp 
            340                 345                 350         


Leu Val Asn Leu Ile Thr Ser Leu Thr Thr Tyr Gly Val Ser Glu Leu 
        355                 360                 365             


Lys Pro Ala Gly Ile Thr Thr Gly Ala Pro Phe Leu Leu Pro Gly Phe 
    370                 375                 380                 


Ala Val Pro Gln Pro Ala Gly Lys Gly His Ser Val Arg Asn Val Gln 
385                 390                 395                 400 


Ala Phe Ala Val Leu Gln Asn Ala Phe Leu Lys Ala Lys Thr Ser Phe 
                405                 410                 415     


Leu Ala Gln Ile Ile Leu Asp Ala Ile Thr Asn Ile Tyr Met Ala Asp 
            420                 425                 430         


Asn Ala Asn Tyr Phe Ile Leu Glu Ser Gln His Thr Leu Ser Gln Phe 
        435                 440                 445             


Ala Glu Lys Ile Ser Lys Leu Pro Glu Val Gln Asn Lys Tyr Phe Glu 
    450                 455                 460                 


Met Leu Glu Phe Val Val Phe Ser Leu Asn Tyr Ile Pro Cys Lys Glu 
465                 470                 475                 480 


Leu Ile Ser Val Ser Ile Leu Leu Lys Ser Ser Ser Ser Tyr His Cys 
                485                 490                 495     


Ser Ile Ile Ala Met Lys Thr Leu Leu Lys Phe Thr Arg His Asp Tyr 
            500                 505                 510         


Ile Phe Lys Asp Val Phe Arg Glu Val Gly Leu Leu Glu Val Met Val 
        515                 520                 525             


Asn Leu Leu His Lys Tyr Ala Ala Leu Leu Lys Asp Pro Thr Gln Ala 
    530                 535                 540                 


Leu Asn Glu Gln Gly Asp Ser Arg Asn Asn Ser Ser Val Glu Asp Gln 
545                 550                 555                 560 


Lys His Leu Ala Leu Leu Val Met Glu Thr Leu Thr Val Leu Leu Gln 
                565                 570                 575     


Gly Ser Asn Thr Asn Ala Gly Ile Phe Arg Glu Phe Gly Gly Ala Arg 
            580                 585                 590         


Cys Ala His Asn Ile Val Lys Tyr Pro Gln Cys Arg Gln His Ala Leu 
        595                 600                 605             


Met Thr Ile Gln Gln Leu Val Leu Ser Pro Asn Gly Asp Asp Asp Met 
    610                 615                 620                 


Gly Thr Leu Leu Gly Leu Met His Ser Ala Pro Pro Thr Glu Leu Gln 
625                 630                 635                 640 


Leu Lys Thr Asp Ile Leu Arg Ala Leu Leu Ser Val Leu Arg Glu Ser 
                645                 650                 655     


His Arg Ser Arg Thr Val Phe Arg Lys Val Gly Gly Phe Val Tyr Ile 
            660                 665                 670         


Thr Ser Leu Leu Val Ala Met Glu Arg Ser Leu Ser Cys Pro Pro Lys 
        675                 680                 685             


Asn Gly Trp Glu Lys Val Asn Gln Asn Gln Val Phe Glu Leu Leu His 
    690                 695                 700                 


Thr Val Phe Cys Thr Leu Thr Ala Ala Met Arg Tyr Glu Pro Ala Asn 
705                 710                 715                 720 


Ser His Phe Phe Lys Thr Glu Ile Gln Tyr Glu Lys Leu Ala Asp Ala 
                725                 730                 735     


Val Arg Phe Leu Gly Cys Phe Ser Asp Leu Arg Lys Ile Ser Ala Met 
            740                 745                 750         


Asn Val Phe Pro Ser Asn Thr Gln Pro Phe Gln Arg Leu Leu Glu Glu 
        755                 760                 765             


Asp Val Ile Ser Ile Glu Ser Val Ser Pro Thr Leu Arg His Cys Ser 
    770                 775                 780                 


Lys Leu Phe Ile Tyr Leu Tyr Lys Val Ala Thr Asp Ser Phe Asp Arg 
785                 790                 795                 800 


Tyr Gly Ser Ala Leu Ser Ser Glu Leu Lys Gly Val Tyr 
                805                 810             


<210>  61
<211>  10567
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (124)..(9279)
<223>  

<400>  61
ctggatccgc tggttccgta acaacatccc gttggcttcc ctcaggcggc gggaccagtg     60

cagccgccgc ctcccaggat cgtccgccgg tcagggccct tgccctcccc ggcacaggcc    120

acc atg gcc acc aac cca cag ccg cag ccg cct cct ccg gcg ccg ccg      168
    Met Ala Thr Asn Pro Gln Pro Gln Pro Pro Pro Pro Ala Pro Pro         
    1               5                   10                  15          

cct ccc ccg ccg cag ccg cag ccg cag cca ccg ccg ccg ccg ccg ggc      216
Pro Pro Pro Pro Gln Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro Gly         
                20                  25                  30              

ccc ggg gct ggc ccc ggc gcg ggc ggg gcg ggc ggc gcg ggt gcg ggc      264
Pro Gly Ala Gly Pro Gly Ala Gly Gly Ala Gly Gly Ala Gly Ala Gly         
            35                  40                  45                  

gcc ggg gac ccg cag ctc gtg gcc atg atc gtg aac cac ctc aag agc      312
Ala Gly Asp Pro Gln Leu Val Ala Met Ile Val Asn His Leu Lys Ser         
        50                  55                  60                      

cag ggg ctc ttc gac cag ttc cgc aga gac tgc ctg gcc gac gtg gac      360
Gln Gly Leu Phe Asp Gln Phe Arg Arg Asp Cys Leu Ala Asp Val Asp         
    65                  70                  75                          

acc aag cct gcg tat cag aat ctg aga cag cgt gtt gac aac ttt gtt      408
Thr Lys Pro Ala Tyr Gln Asn Leu Arg Gln Arg Val Asp Asn Phe Val         
80                  85                  90                  95          

gca aat cac ttg gca act cac aca tgg agt ccg cat ctc aat aag aac      456
Ala Asn His Leu Ala Thr His Thr Trp Ser Pro His Leu Asn Lys Asn         
                100                 105                 110             

cag cta aga aac aac att aga caa caa gtc ctc aaa tca gga atg ttg      504
Gln Leu Arg Asn Asn Ile Arg Gln Gln Val Leu Lys Ser Gly Met Leu         
            115                 120                 125                 

gag tct ggt att gac cga att att tct cag gtt gtg gac cca aag atc      552
Glu Ser Gly Ile Asp Arg Ile Ile Ser Gln Val Val Asp Pro Lys Ile         
        130                 135                 140                     

aac cac aca ttc aga cct cag gta gag aaa gct gtg cat gag ttt ttg      600
Asn His Thr Phe Arg Pro Gln Val Glu Lys Ala Val His Glu Phe Leu         
    145                 150                 155                         

gcc acg cta aat cac aaa gag gaa gga agt ggc aac aca gct ccc gat      648
Ala Thr Leu Asn His Lys Glu Glu Gly Ser Gly Asn Thr Ala Pro Asp         
160                 165                 170                 175         

gat gag aaa cca gac act tcc ctt att aca caa ggt gtt cct act cct      696
Asp Glu Lys Pro Asp Thr Ser Leu Ile Thr Gln Gly Val Pro Thr Pro         
                180                 185                 190             

ggg ccc agt gct aat gta gcc aat gat gcc atg tcg ata ttg gaa acc      744
Gly Pro Ser Ala Asn Val Ala Asn Asp Ala Met Ser Ile Leu Glu Thr         
            195                 200                 205                 

ata act tct ctt aac caa gaa gcc agt gct gct agg gct tca aca gaa      792
Ile Thr Ser Leu Asn Gln Glu Ala Ser Ala Ala Arg Ala Ser Thr Glu         
        210                 215                 220                     

aca tca aat gcc aag acc agt gag aga gcg tca aaa aaa ctt cca tct      840
Thr Ser Asn Ala Lys Thr Ser Glu Arg Ala Ser Lys Lys Leu Pro Ser         
    225                 230                 235                         

cag cca acc act gat act agt act gac aaa gaa aga act tca gag gac      888
Gln Pro Thr Thr Asp Thr Ser Thr Asp Lys Glu Arg Thr Ser Glu Asp         
240                 245                 250                 255         

atg gct gat aaa gaa aaa tct aca gct gac tct gga ggt gaa gga ctg      936
Met Ala Asp Lys Glu Lys Ser Thr Ala Asp Ser Gly Gly Glu Gly Leu         
                260                 265                 270             

gaa aca gcc cca aag tct gaa gag ttc agc gac ctc ccc tgt cca gtc      984
Glu Thr Ala Pro Lys Ser Glu Glu Phe Ser Asp Leu Pro Cys Pro Val         
            275                 280                 285                 

gaa gaa att aaa aat tac aca aaa gag cat aat aat tta att ctg cta     1032
Glu Glu Ile Lys Asn Tyr Thr Lys Glu His Asn Asn Leu Ile Leu Leu         
        290                 295                 300                     

aat aag gat gtt caa cag gaa agc agt gag caa aaa aat aaa tca aca     1080
Asn Lys Asp Val Gln Gln Glu Ser Ser Glu Gln Lys Asn Lys Ser Thr         
    305                 310                 315                         

gac aaa ggt gaa aag aag cca gac agc aat gag aaa gga gaa aga aag     1128
Asp Lys Gly Glu Lys Lys Pro Asp Ser Asn Glu Lys Gly Glu Arg Lys         
320                 325                 330                 335         

aaa gaa aag aag gaa aag act gaa aag aaa ttt gat cac tca aaa aag     1176
Lys Glu Lys Lys Glu Lys Thr Glu Lys Lys Phe Asp His Ser Lys Lys         
                340                 345                 350             

agt gaa gat aca cag aaa gtt aaa gat gaa aaa caa gca aag gaa aaa     1224
Ser Glu Asp Thr Gln Lys Val Lys Asp Glu Lys Gln Ala Lys Glu Lys         
            355                 360                 365                 

gaa gta gag agt tta aaa ctt cct tca gaa aag aac agt aat aaa gct     1272
Glu Val Glu Ser Leu Lys Leu Pro Ser Glu Lys Asn Ser Asn Lys Ala         
        370                 375                 380                     

aaa act gtt gaa ggg aca aaa gaa gat ttc tct ttg ata gat tct gat     1320
Lys Thr Val Glu Gly Thr Lys Glu Asp Phe Ser Leu Ile Asp Ser Asp         
    385                 390                 395                         

gtg gat gga ctt aca gac atc aca gtt agc tct gtt cat acc agt gac     1368
Val Asp Gly Leu Thr Asp Ile Thr Val Ser Ser Val His Thr Ser Asp         
400                 405                 410                 415         

ctt tca tct ttt gaa gaa gat act gag gag gaa gtt gta acg tct gat     1416
Leu Ser Ser Phe Glu Glu Asp Thr Glu Glu Glu Val Val Thr Ser Asp         
                420                 425                 430             

agc atg gaa gaa gga gag att acg tca gat gat gaa gag aag aac aaa     1464
Ser Met Glu Glu Gly Glu Ile Thr Ser Asp Asp Glu Glu Lys Asn Lys         
            435                 440                 445                 

cag aat aaa aca aaa act caa act agt gat tct agt gaa gga aaa aca     1512
Gln Asn Lys Thr Lys Thr Gln Thr Ser Asp Ser Ser Glu Gly Lys Thr         
        450                 455                 460                     

aaa agt gta cgg cat gcg tat gtc cac aaa cca tat ctt tac tca aaa     1560
Lys Ser Val Arg His Ala Tyr Val His Lys Pro Tyr Leu Tyr Ser Lys         
    465                 470                 475                         

tac tat agt gat tct gat gat gag ctt act gta gaa caa cga cga cag     1608
Tyr Tyr Ser Asp Ser Asp Asp Glu Leu Thr Val Glu Gln Arg Arg Gln         
480                 485                 490                 495         

tcc att gcc aaa gaa aaa gaa gag agg ctt tta aga agg caa atc aat     1656
Ser Ile Ala Lys Glu Lys Glu Glu Arg Leu Leu Arg Arg Gln Ile Asn         
                500                 505                 510             

aga gaa aaa ctt gaa gaa aaa cga aaa cag aaa gca gaa aag aca aag     1704
Arg Glu Lys Leu Glu Glu Lys Arg Lys Gln Lys Ala Glu Lys Thr Lys         
            515                 520                 525                 

tct tca aaa acc aag ggt caa ggc agg agt agt gtg gac tta gaa gaa     1752
Ser Ser Lys Thr Lys Gly Gln Gly Arg Ser Ser Val Asp Leu Glu Glu         
        530                 535                 540                     

tca tca aca aag agt ttg gaa cct aaa gcc gcc aga att aaa gaa gtc     1800
Ser Ser Thr Lys Ser Leu Glu Pro Lys Ala Ala Arg Ile Lys Glu Val         
    545                 550                 555                         

ctt aaa gaa cgg aaa gtt tta gaa aaa aaa gta gcc tta agc aaa aag     1848
Leu Lys Glu Arg Lys Val Leu Glu Lys Lys Val Ala Leu Ser Lys Lys         
560                 565                 570                 575         

aga aaa aaa gat tca agg aat gtt gaa gag aac tcc aaa aag aaa cag     1896
Arg Lys Lys Asp Ser Arg Asn Val Glu Glu Asn Ser Lys Lys Lys Gln         
                580                 585                 590             

caa tat gaa gaa gat tcc aaa gaa acc ctt aaa aca agt gag cat tgt     1944
Gln Tyr Glu Glu Asp Ser Lys Glu Thr Leu Lys Thr Ser Glu His Cys         
            595                 600                 605                 

gaa aag gaa aaa att tct tct tca aag gag ctg aag cat gtt cat gca     1992
Glu Lys Glu Lys Ile Ser Ser Ser Lys Glu Leu Lys His Val His Ala         
        610                 615                 620                     

aaa agt gaa cca agt aaa cct gcc cgg aga ctt tca gag tct ttg cat     2040
Lys Ser Glu Pro Ser Lys Pro Ala Arg Arg Leu Ser Glu Ser Leu His         
    625                 630                 635                         

gta gtt gac gaa aac aaa aat gaa tcc aaa ata gaa aga gaa cat aaa     2088
Val Val Asp Glu Asn Lys Asn Glu Ser Lys Ile Glu Arg Glu His Lys         
640                 645                 650                 655         

aga cgg aca tct acc cct gtt atc atg gag ggg gta cag gaa gag act     2136
Arg Arg Thr Ser Thr Pro Val Ile Met Glu Gly Val Gln Glu Glu Thr         
                660                 665                 670             

gac aca aga gat gta aaa agg caa gta gaa cgc tca gaa att tgc acc     2184
Asp Thr Arg Asp Val Lys Arg Gln Val Glu Arg Ser Glu Ile Cys Thr         
            675                 680                 685                 

gaa gag ccc cag aaa cag aaa agc aca ctt aaa aac gaa aag cat cta     2232
Glu Glu Pro Gln Lys Gln Lys Ser Thr Leu Lys Asn Glu Lys His Leu         
        690                 695                 700                     

aag aaa gat gat tct gaa aca cca cat ttg aaa agc cta ctt aag aaa     2280
Lys Lys Asp Asp Ser Glu Thr Pro His Leu Lys Ser Leu Leu Lys Lys         
    705                 710                 715                         

gag gtg aaa tcc tcc aag gag aag cct gaa aga gag aaa act cca tcg     2328
Glu Val Lys Ser Ser Lys Glu Lys Pro Glu Arg Glu Lys Thr Pro Ser         
720                 725                 730                 735         

gaa gac aaa ttg tct gtg aaa cat aaa tat aaa ggt gat tgt atg cat     2376
Glu Asp Lys Leu Ser Val Lys His Lys Tyr Lys Gly Asp Cys Met His         
                740                 745                 750             

aaa aca ggt gat gag act gag ctt cac tct tct gag aaa ggt tta aaa     2424
Lys Thr Gly Asp Glu Thr Glu Leu His Ser Ser Glu Lys Gly Leu Lys         
            755                 760                 765                 

gta gag gaa aat att caa aag caa agt caa caa aca aag ctt tct tca     2472
Val Glu Glu Asn Ile Gln Lys Gln Ser Gln Gln Thr Lys Leu Ser Ser         
        770                 775                 780                     

gat gat aaa acc gaa cga aaa agt aaa cat agg aat gaa agg aaa tta     2520
Asp Asp Lys Thr Glu Arg Lys Ser Lys His Arg Asn Glu Arg Lys Leu         
    785                 790                 795                         

tca gta tta ggc aaa gat gga aag cca gtt tct gaa tat att ata aaa     2568
Ser Val Leu Gly Lys Asp Gly Lys Pro Val Ser Glu Tyr Ile Ile Lys         
800                 805                 810                 815         

aca gat gag aat gtt cgt aaa gaa aac aac aaa aaa gag aga cgc ttg     2616
Thr Asp Glu Asn Val Arg Lys Glu Asn Asn Lys Lys Glu Arg Arg Leu         
                820                 825                 830             

tca gct gaa aaa act aag gca gag cac aaa tca aga agg tca agt gat     2664
Ser Ala Glu Lys Thr Lys Ala Glu His Lys Ser Arg Arg Ser Ser Asp         
            835                 840                 845                 

tct aaa att cag aaa gat tct ctg ggt tcc aag caa cat ggt atc aca     2712
Ser Lys Ile Gln Lys Asp Ser Leu Gly Ser Lys Gln His Gly Ile Thr         
        850                 855                 860                     

tta cag aga aga agt gaa agt tat tcg gaa gat aag tgt gat atg gac     2760
Leu Gln Arg Arg Ser Glu Ser Tyr Ser Glu Asp Lys Cys Asp Met Asp         
    865                 870                 875                         

tcc act aac atg gat agt aat ttg aaa cca gaa gag gtt gtt cac aag     2808
Ser Thr Asn Met Asp Ser Asn Leu Lys Pro Glu Glu Val Val His Lys         
880                 885                 890                 895         

gag aaa cga cga aca aag agc ttg tta gaa gag aaa ctt gtg ttg aag     2856
Glu Lys Arg Arg Thr Lys Ser Leu Leu Glu Glu Lys Leu Val Leu Lys         
                900                 905                 910             

tct aaa tca aaa act caa ggc aaa cag gta aaa gtt gta gaa aca gaa     2904
Ser Lys Ser Lys Thr Gln Gly Lys Gln Val Lys Val Val Glu Thr Glu         
            915                 920                 925                 

tta caa gaa ggt gcc aca aaa cag gca acc act cca aaa cca gac aag     2952
Leu Gln Glu Gly Ala Thr Lys Gln Ala Thr Thr Pro Lys Pro Asp Lys         
        930                 935                 940                     

gag aag aac aca gaa gaa aat gac tca gaa aaa cag cgt aag tct aaa     3000
Glu Lys Asn Thr Glu Glu Asn Asp Ser Glu Lys Gln Arg Lys Ser Lys         
    945                 950                 955                         

gtt gaa gac aaa cct ttt gaa gaa act ggt gtt gaa cct gta tta gag     3048
Val Glu Asp Lys Pro Phe Glu Glu Thr Gly Val Glu Pro Val Leu Glu         
960                 965                 970                 975         

act gct tct tct tca gca cat agt aca cag aag gat tct agt cat aga     3096
Thr Ala Ser Ser Ser Ala His Ser Thr Gln Lys Asp Ser Ser His Arg         
                980                 985                 990             

gcc aag tta cca tta gca aag gag aaa  tat aag agt gat aaa  gac tcc   3144
Ala Lys Leu Pro Leu Ala Lys Glu Lys  Tyr Lys Ser Asp Lys  Asp Ser       
            995                 1000                 1005               

act tcc acc  agg ctt gag aga aag  ttg tca gat ggc cac  aaa agc      3189
Thr Ser Thr  Arg Leu Glu Arg Lys  Leu Ser Asp Gly His  Lys Ser          
        1010                 1015                 1020                  

aga agc tta  aag cat agt agt aaa  gac ata aaa aag aag  gac gaa      3234
Arg Ser Leu  Lys His Ser Ser Lys  Asp Ile Lys Lys Lys  Asp Glu          
        1025                 1030                 1035                  

aat aaa tca  gat gac aag gat ggt  aaa gaa gtt gac agt  agt cat      3279
Asn Lys Ser  Asp Asp Lys Asp Gly  Lys Glu Val Asp Ser  Ser His          
        1040                 1045                 1050                  

gaa aag gcc  aga ggt aat agt tca  ctc atg gaa aag aaa  tta agt      3324
Glu Lys Ala  Arg Gly Asn Ser Ser  Leu Met Glu Lys Lys  Leu Ser          
        1055                 1060                 1065                  

aga agg ttg  tgc gaa aat cgg aga  gga agc ttg tca caa  gaa atg      3369
Arg Arg Leu  Cys Glu Asn Arg Arg  Gly Ser Leu Ser Gln  Glu Met          
        1070                 1075                 1080                  

gcc aaa gga  gaa gaa aaa tta gca  gca aac act ttg agc  act ccc      3414
Ala Lys Gly  Glu Glu Lys Leu Ala  Ala Asn Thr Leu Ser  Thr Pro          
        1085                 1090                 1095                  

agc ggt tcc  tcc ctt cag aga cca  aaa aag agt ggt gat  atg aca      3459
Ser Gly Ser  Ser Leu Gln Arg Pro  Lys Lys Ser Gly Asp  Met Thr          
        1100                 1105                 1110                  

ttg atc cct  gaa caa gag cca atg  gaa att gat tct gag  cca ggt      3504
Leu Ile Pro  Glu Gln Glu Pro Met  Glu Ile Asp Ser Glu  Pro Gly          
        1115                 1120                 1125                  

gtt gaa aat  gtg ttt gaa gta tct  aaa acc caa gac aac  cgc aat      3549
Val Glu Asn  Val Phe Glu Val Ser  Lys Thr Gln Asp Asn  Arg Asn          
        1130                 1135                 1140                  

aat aat tct  cag caa gac att gac  tct gaa aat atg aaa  caa aaa      3594
Asn Asn Ser  Gln Gln Asp Ile Asp  Ser Glu Asn Met Lys  Gln Lys          
        1145                 1150                 1155                  

act tct gcc  act gtt caa aag gat  gaa ttg aga act tgc  aca gca      3639
Thr Ser Ala  Thr Val Gln Lys Asp  Glu Leu Arg Thr Cys  Thr Ala          
        1160                 1165                 1170                  

gat tca aaa  gca aca gct cca gct  tat aag cca ggc cgt  gga aca      3684
Asp Ser Lys  Ala Thr Ala Pro Ala  Tyr Lys Pro Gly Arg  Gly Thr          
        1175                 1180                 1185                  

gga gtt aat  agt aat tct gaa aag  cat gcc gat cat aga  agc acc      3729
Gly Val Asn  Ser Asn Ser Glu Lys  His Ala Asp His Arg  Ser Thr          
        1190                 1195                 1200                  

ttg acc aag  aaa atg cat ata caa  agt gct gtg tcc aaa  atg aac      3774
Leu Thr Lys  Lys Met His Ile Gln  Ser Ala Val Ser Lys  Met Asn          
        1205                 1210                 1215                  

cct ggg gag  aaa gaa ccc att cat  aga gga act act gaa  gtg aat      3819
Pro Gly Glu  Lys Glu Pro Ile His  Arg Gly Thr Thr Glu  Val Asn          
        1220                 1225                 1230                  

ata gat tct  gaa act gtt cat aga  atg tta ctg agt gcc  cca tca      3864
Ile Asp Ser  Glu Thr Val His Arg  Met Leu Leu Ser Ala  Pro Ser          
        1235                 1240                 1245                  

gaa aat gat  agg gta cag aag aat  ttg aaa aac aca gct  gct gaa      3909
Glu Asn Asp  Arg Val Gln Lys Asn  Leu Lys Asn Thr Ala  Ala Glu          
        1250                 1255                 1260                  

gaa cat gtt  gct caa gga gat gcc  act ctt gaa cat tcc  aca aat      3954
Glu His Val  Ala Gln Gly Asp Ala  Thr Leu Glu His Ser  Thr Asn          
        1265                 1270                 1275                  

tta gac tcc  tca cca tcc tta agt  tca gtg act gtt gtg  cct ctg      3999
Leu Asp Ser  Ser Pro Ser Leu Ser  Ser Val Thr Val Val  Pro Leu          
        1280                 1285                 1290                  

agg gaa tcg  tat gat cca gat gta  att cct ctg ttt gac  aaa aga      4044
Arg Glu Ser  Tyr Asp Pro Asp Val  Ile Pro Leu Phe Asp  Lys Arg          
        1295                 1300                 1305                  

act gtt ttg  gaa ggt agc aca gcc  agc acc tcc cct gcg  gat cac      4089
Thr Val Leu  Glu Gly Ser Thr Ala  Ser Thr Ser Pro Ala  Asp His          
        1310                 1315                 1320                  

tct gct ctc  cct aac caa agt ctg  act gtt agg gaa tca  gaa gtc      4134
Ser Ala Leu  Pro Asn Gln Ser Leu  Thr Val Arg Glu Ser  Glu Val          
        1325                 1330                 1335                  

ctt aag aca  agt gac agc aaa gaa  ggt ggt gaa ggt ttc  aca gta      4179
Leu Lys Thr  Ser Asp Ser Lys Glu  Gly Gly Glu Gly Phe  Thr Val          
        1340                 1345                 1350                  

gat aca cca  gca aaa gca agc atc  act agc aaa aga cac  att cca      4224
Asp Thr Pro  Ala Lys Ala Ser Ile  Thr Ser Lys Arg His  Ile Pro          
        1355                 1360                 1365                  

gaa gct cac  cag gct act tta ttg  gat ggt aaa caa gga  aag gta      4269
Glu Ala His  Gln Ala Thr Leu Leu  Asp Gly Lys Gln Gly  Lys Val          
        1370                 1375                 1380                  

atc atg cct  ctt gga agt aag tta  acg ggc gtg att gtg  gaa aat      4314
Ile Met Pro  Leu Gly Ser Lys Leu  Thr Gly Val Ile Val  Glu Asn          
        1385                 1390                 1395                  

gag aat att  acc aaa gaa ggt ggc  tta gtg gac atg gcc  aag aaa      4359
Glu Asn Ile  Thr Lys Glu Gly Gly  Leu Val Asp Met Ala  Lys Lys          
        1400                 1405                 1410                  

gaa aat gac  tta aat gca gag ccc  aat tta aag cag aca  att aaa      4404
Glu Asn Asp  Leu Asn Ala Glu Pro  Asn Leu Lys Gln Thr  Ile Lys          
        1415                 1420                 1425                  

gca aca gta  gag aat ggc aag aag  gat ggc att gct gtt  gat cat      4449
Ala Thr Val  Glu Asn Gly Lys Lys  Asp Gly Ile Ala Val  Asp His          
        1430                 1435                 1440                  

gtt gta ggc  ctg aat aca gaa aaa  tat gct gaa act gtc  aaa ctt      4494
Val Val Gly  Leu Asn Thr Glu Lys  Tyr Ala Glu Thr Val  Lys Leu          
        1445                 1450                 1455                  

aag cat aaa  aga agc cca ggt aaa  gta aaa gac ata tca  att gat      4539
Lys His Lys  Arg Ser Pro Gly Lys  Val Lys Asp Ile Ser  Ile Asp          
        1460                 1465                 1470                  

gtt gaa aga  agg aat gaa aac agt  gag gta gac acc agt  gct gga      4584
Val Glu Arg  Arg Asn Glu Asn Ser  Glu Val Asp Thr Ser  Ala Gly          
        1475                 1480                 1485                  

agt ggc tct  gca ccc tct gtt tta  cac caa agg aac gga  caa act      4629
Ser Gly Ser  Ala Pro Ser Val Leu  His Gln Arg Asn Gly  Gln Thr          
        1490                 1495                 1500                  

gag gat gtg  gca act ggg cct agg  aga gca gaa aag act  tct gtt      4674
Glu Asp Val  Ala Thr Gly Pro Arg  Arg Ala Glu Lys Thr  Ser Val          
        1505                 1510                 1515                  

gcc act agt  act gaa ggg aag gac  aaa gat gtc acc tta  agt cca      4719
Ala Thr Ser  Thr Glu Gly Lys Asp  Lys Asp Val Thr Leu  Ser Pro          
        1520                 1525                 1530                  

gtg aag gct  ggg cct gcc aca acc  act tct tca gaa aca  aga caa      4764
Val Lys Ala  Gly Pro Ala Thr Thr  Thr Ser Ser Glu Thr  Arg Gln          
        1535                 1540                 1545                  

agt gag gtg  gct ttg cct tgc acc  agc att gag gca gat  gaa ggc      4809
Ser Glu Val  Ala Leu Pro Cys Thr  Ser Ile Glu Ala Asp  Glu Gly          
        1550                 1555                 1560                  

ctc ata ata  gga aca cat tcc aga  aat aat cct ctt cat  gtt ggt      4854
Leu Ile Ile  Gly Thr His Ser Arg  Asn Asn Pro Leu His  Val Gly          
        1565                 1570                 1575                  

gca gaa gcc  agt gaa tgc act gtt  ttt gct gca gct gaa  gaa ggt      4899
Ala Glu Ala  Ser Glu Cys Thr Val  Phe Ala Ala Ala Glu  Glu Gly          
        1580                 1585                 1590                  

ggg gct gtt  gtc aca gag gga ttt  gct gaa agt gaa acc  ttc ctc      4944
Gly Ala Val  Val Thr Glu Gly Phe  Ala Glu Ser Glu Thr  Phe Leu          
        1595                 1600                 1605                  

aca agc act  aag gaa ggg gaa agt  ggg gag tgt gct gtg  gct gaa      4989
Thr Ser Thr  Lys Glu Gly Glu Ser  Gly Glu Cys Ala Val  Ala Glu          
        1610                 1615                 1620                  

tct gag gac  aga gca gca gac cta  ctg gct gtg cat gca  gtt aaa      5034
Ser Glu Asp  Arg Ala Ala Asp Leu  Leu Ala Val His Ala  Val Lys          
        1625                 1630                 1635                  

atc gaa gcc  aat gta aat agc gtt  gtg aca gag gaa aag  gat gat      5079
Ile Glu Ala  Asn Val Asn Ser Val  Val Thr Glu Glu Lys  Asp Asp          
        1640                 1645                 1650                  

gct gta acc  agt gca ggc tct gaa  gaa aaa tgt gat ggt  tct tta      5124
Ala Val Thr  Ser Ala Gly Ser Glu  Glu Lys Cys Asp Gly  Ser Leu          
        1655                 1660                 1665                  

agt aga gac  tca gaa ata gtt gaa  gga act att act ttt  att agt      5169
Ser Arg Asp  Ser Glu Ile Val Glu  Gly Thr Ile Thr Phe  Ile Ser          
        1670                 1675                 1680                  

gaa gtt gaa  agt gat gga gca gtt  aca agt gct gga aca  gag ata      5214
Glu Val Glu  Ser Asp Gly Ala Val  Thr Ser Ala Gly Thr  Glu Ile          
        1685                 1690                 1695                  

aga gca gga  tct ata agc agt gaa  gag gtg gat ggc tcc  cag gga      5259
Arg Ala Gly  Ser Ile Ser Ser Glu  Glu Val Asp Gly Ser  Gln Gly          
        1700                 1705                 1710                  

aat atg atg  aga atg ggt ccc aaa  aaa gaa aca gag ggc  act gtg      5304
Asn Met Met  Arg Met Gly Pro Lys  Lys Glu Thr Glu Gly  Thr Val          
        1715                 1720                 1725                  

aca tgt aca  gga gca gaa ggc aga  agt gat aac ttt gtg  atc tgc      5349
Thr Cys Thr  Gly Ala Glu Gly Arg  Ser Asp Asn Phe Val  Ile Cys          
        1730                 1735                 1740                  

tca gta act  gga gca ggg ccc cgg  gag gaa cgc atg gtt  aca ggt      5394
Ser Val Thr  Gly Ala Gly Pro Arg  Glu Glu Arg Met Val  Thr Gly          
        1745                 1750                 1755                  

gca ggt gtt  gtc ctg gga gat aat  gat gca cca cca gga  aca agt      5439
Ala Gly Val  Val Leu Gly Asp Asn  Asp Ala Pro Pro Gly  Thr Ser          
        1760                 1765                 1770                  

gcc agc caa  gaa gga gat ggt tct  gtg aat gat ggt aca  gaa ggt      5484
Ala Ser Gln  Glu Gly Asp Gly Ser  Val Asn Asp Gly Thr  Glu Gly          
        1775                 1780                 1785                  

gag agt gca  gtc acc agc acg ggg  ata aca gaa gat gga  gag ggg      5529
Glu Ser Ala  Val Thr Ser Thr Gly  Ile Thr Glu Asp Gly  Glu Gly          
        1790                 1795                 1800                  

cca gca agt  tgc aca ggt tca gaa  gat agc agc gaa ggc  ttt gct      5574
Pro Ala Ser  Cys Thr Gly Ser Glu  Asp Ser Ser Glu Gly  Phe Ala          
        1805                 1810                 1815                  

ata agt tct  gaa tcg gaa gaa aat  gga gag agt gca atg  gac agc      5619
Ile Ser Ser  Glu Ser Glu Glu Asn  Gly Glu Ser Ala Met  Asp Ser          
        1820                 1825                 1830                  

aca gtg gcc  aaa gaa ggc act aat  gta cca tta gtt gct  gct ggt      5664
Thr Val Ala  Lys Glu Gly Thr Asn  Val Pro Leu Val Ala  Ala Gly          
        1835                 1840                 1845                  

cct tgt gat  gat gaa ggc att gtg  act agc aca ggc gca  aaa gag      5709
Pro Cys Asp  Asp Glu Gly Ile Val  Thr Ser Thr Gly Ala  Lys Glu          
        1850                 1855                 1860                  

gaa gac gag  gaa ggg gag gat gtt  gtg act agt act gga  aga gga      5754
Glu Asp Glu  Glu Gly Glu Asp Val  Val Thr Ser Thr Gly  Arg Gly          
        1865                 1870                 1875                  

aat gaa att  ggg cat gct tca act  tgt aca ggg tta gga  gaa gaa      5799
Asn Glu Ile  Gly His Ala Ser Thr  Cys Thr Gly Leu Gly  Glu Glu          
        1880                 1885                 1890                  

agt gaa ggg  gtc ttg att tgt gaa  agt gca gaa ggg gac  agt cag      5844
Ser Glu Gly  Val Leu Ile Cys Glu  Ser Ala Glu Gly Asp  Ser Gln          
        1895                 1900                 1905                  

att ggt act  gtg gta gag cat gtg  gaa gct gag gct gga  gct gcc      5889
Ile Gly Thr  Val Val Glu His Val  Glu Ala Glu Ala Gly  Ala Ala          
        1910                 1915                 1920                  

atc atg aat  gca aat gaa aat aat  gtt gac agc atg agt  ggc aca      5934
Ile Met Asn  Ala Asn Glu Asn Asn  Val Asp Ser Met Ser  Gly Thr          
        1925                 1930                 1935                  

gag aaa gga  agt aaa gac aca gat  atc tgc tcc agt gca  aaa ggg      5979
Glu Lys Gly  Ser Lys Asp Thr Asp  Ile Cys Ser Ser Ala  Lys Gly          
        1940                 1945                 1950                  

att gta gaa  agc agt gtg acc agt  gca gtc tca gga aag  gat gaa      6024
Ile Val Glu  Ser Ser Val Thr Ser  Ala Val Ser Gly Lys  Asp Glu          
        1955                 1960                 1965                  

gtg aca cca  gtt cca gga ggt tgt  gag ggt cct atg act  agt gct      6069
Val Thr Pro  Val Pro Gly Gly Cys  Glu Gly Pro Met Thr  Ser Ala          
        1970                 1975                 1980                  

gca tct gat  caa agt gac agt cag  ctc gaa aaa gtt gaa  gat acc      6114
Ala Ser Asp  Gln Ser Asp Ser Gln  Leu Glu Lys Val Glu  Asp Thr          
        1985                 1990                 1995                  

act att tcc  act ggc ctg gtc ggg  ggt agt tac gat gtt  ctt gta      6159
Thr Ile Ser  Thr Gly Leu Val Gly  Gly Ser Tyr Asp Val  Leu Val          
        2000                 2005                 2010                  

tct ggt gaa  gtc cca gaa tgt gaa  gtt gct cac aca tca  cca agt      6204
Ser Gly Glu  Val Pro Glu Cys Glu  Val Ala His Thr Ser  Pro Ser          
        2015                 2020                 2025                  

gaa aaa gaa  gat gag gac atc atc  acc tct gta gaa aat  gaa gag      6249
Glu Lys Glu  Asp Glu Asp Ile Ile  Thr Ser Val Glu Asn  Glu Glu          
        2030                 2035                 2040                  

tgt gat ggt  ctc atg gca act aca  gcc agt ggt gat att  acc aac      6294
Cys Asp Gly  Leu Met Ala Thr Thr  Ala Ser Gly Asp Ile  Thr Asn          
        2045                 2050                 2055                  

cag aat agc  tta gca ggg ggt aaa  aat caa ggc aaa gtt  ttg att      6339
Gln Asn Ser  Leu Ala Gly Gly Lys  Asn Gln Gly Lys Val  Leu Ile          
        2060                 2065                 2070                  

att tcc acc  agt acc aca aat gat  tac acc cct cag gta  agc gca      6384
Ile Ser Thr  Ser Thr Thr Asn Asp  Tyr Thr Pro Gln Val  Ser Ala          
        2075                 2080                 2085                  

att aca gat  gtg gaa gga ggt ctc  tca gat gct ctg aga  act gaa      6429
Ile Thr Asp  Val Glu Gly Gly Leu  Ser Asp Ala Leu Arg  Thr Glu          
        2090                 2095                 2100                  

gaa aat atg  gaa ggt acc aga gta  acc aca gaa gaa ttt  gag gcc      6474
Glu Asn Met  Glu Gly Thr Arg Val  Thr Thr Glu Glu Phe  Glu Ala          
        2105                 2110                 2115                  

ccc atg ccc  agt gca gtc tca gga  gat gac agc caa ctc  act gcc      6519
Pro Met Pro  Ser Ala Val Ser Gly  Asp Asp Ser Gln Leu  Thr Ala          
        2120                 2125                 2130                  

agc aga agt  gaa gag aaa gat gag  tgt gcc atg att tcc  aca agc      6564
Ser Arg Ser  Glu Glu Lys Asp Glu  Cys Ala Met Ile Ser  Thr Ser          
        2135                 2140                 2145                  

ata ggg gaa  gaa ttc gaa ttg cct  atc tcc agt gca aca  acc atc      6609
Ile Gly Glu  Glu Phe Glu Leu Pro  Ile Ser Ser Ala Thr  Thr Ile          
        2150                 2155                 2160                  

aag tgt gct  gaa agt ctt cag ccg  gtt gct gca gca gtg  gaa gaa      6654
Lys Cys Ala  Glu Ser Leu Gln Pro  Val Ala Ala Ala Val  Glu Glu          
        2165                 2170                 2175                  

agg gct aca  ggt cca gtc ttg ata  agc acc gcc gac ttt  gag ggg      6699
Arg Ala Thr  Gly Pro Val Leu Ile  Ser Thr Ala Asp Phe  Glu Gly          
        2180                 2185                 2190                  

cct atg ccc  agt gcg ccc cca gaa  gct gaa agt cct ctt  gcc tca      6744
Pro Met Pro  Ser Ala Pro Pro Glu  Ala Glu Ser Pro Leu  Ala Ser          
        2195                 2200                 2205                  

acc agc aag  gag gag aag gat gaa  tgt gct ctc att tcc  act agc      6789
Thr Ser Lys  Glu Glu Lys Asp Glu  Cys Ala Leu Ile Ser  Thr Ser          
        2210                 2215                 2220                  

ata gca gaa  gaa tgt gag gct tct  gtt tcc ggt gta gtt  gtt gaa      6834
Ile Ala Glu  Glu Cys Glu Ala Ser  Val Ser Gly Val Val  Val Glu          
        2225                 2230                 2235                  

agt gaa aat  gag cga gct ggc aca  gtc atg gaa gaa aaa  gac ggg      6879
Ser Glu Asn  Glu Arg Ala Gly Thr  Val Met Glu Glu Lys  Asp Gly          
        2240                 2245                 2250                  

agt ggc atc  atc tct acg agc tcg  gtg gaa gac tgt gag  ggc cca      6924
Ser Gly Ile  Ile Ser Thr Ser Ser  Val Glu Asp Cys Glu  Gly Pro          
        2255                 2260                 2265                  

gtg tcc agt  gct gtc cct caa gag  gaa ggc gac ccc tca  gtc aca      6969
Val Ser Ser  Ala Val Pro Gln Glu  Glu Gly Asp Pro Ser  Val Thr          
        2270                 2275                 2280                  

cca gcg gaa  gag atg ggt gac acc  gcc atg att tcc aca  agc acc      7014
Pro Ala Glu  Glu Met Gly Asp Thr  Ala Met Ile Ser Thr  Ser Thr          
        2285                 2290                 2295                  

tct gaa ggg  tgt gaa gca gtc atg  att ggt gct gtc ctc  cag gat      7059
Ser Glu Gly  Cys Glu Ala Val Met  Ile Gly Ala Val Leu  Gln Asp          
        2300                 2305                 2310                  

gaa gat cgg  ctc acc atc aca aga  gta gaa gac ttg agc  gat gct      7104
Glu Asp Arg  Leu Thr Ile Thr Arg  Val Glu Asp Leu Ser  Asp Ala          
        2315                 2320                 2325                  

gcc atc atc  tcc acc agc aca gca  gaa tgt atg cca att  tcc gcc      7149
Ala Ile Ile  Ser Thr Ser Thr Ala  Glu Cys Met Pro Ile  Ser Ala          
        2330                 2335                 2340                  

agc att gac  aga cat gaa gag aat  cag ctg act gca gac  aac cca      7194
Ser Ile Asp  Arg His Glu Glu Asn  Gln Leu Thr Ala Asp  Asn Pro          
        2345                 2350                 2355                  

gaa ggg aac  ggt gac ctg tca gcc  aca gaa gtg agc aag  cac aag      7239
Glu Gly Asn  Gly Asp Leu Ser Ala  Thr Glu Val Ser Lys  His Lys          
        2360                 2365                 2370                  

gtc ccc atg  ccc agc cta att gct  gag aat aac tgt cgg  tgt cct      7284
Val Pro Met  Pro Ser Leu Ile Ala  Glu Asn Asn Cys Arg  Cys Pro          
        2375                 2380                 2385                  

ggg cca gtc  agg gga ggc aaa gaa  ccg ggt ccc gtg ttg  gca gtg      7329
Gly Pro Val  Arg Gly Gly Lys Glu  Pro Gly Pro Val Leu  Ala Val          
        2390                 2395                 2400                  

agc acc gag  gag ggg cac aac ggg  cca tca gtc cac aag  ccc tct      7374
Ser Thr Glu  Glu Gly His Asn Gly  Pro Ser Val His Lys  Pro Ser          
        2405                 2410                 2415                  

gca ggg caa  ggc cat cca agt gct  gtt tgt gcg gaa aaa  gaa gag      7419
Ala Gly Gln  Gly His Pro Ser Ala  Val Cys Ala Glu Lys  Glu Glu          
        2420                 2425                 2430                  

aag cat ggc  aag gag tgc ccc gaa  ata gga cca ttt gca  gga aga      7464
Lys His Gly  Lys Glu Cys Pro Glu  Ile Gly Pro Phe Ala  Gly Arg          
        2435                 2440                 2445                  

gga cag aaa  gag agc act tta cac  ctc ata aat gca gaa  gag aag      7509
Gly Gln Lys  Glu Ser Thr Leu His  Leu Ile Asn Ala Glu  Glu Lys          
        2450                 2455                 2460                  

aat gta ttg  ttg aac tcc ctt cag  aaa gaa gat aag agc  cca gag      7554
Asn Val Leu  Leu Asn Ser Leu Gln  Lys Glu Asp Lys Ser  Pro Glu          
        2465                 2470                 2475                  

aca ggg aca  gca ggg ggc agt agc  aca gca agt tat tca  gca gga      7599
Thr Gly Thr  Ala Gly Gly Ser Ser  Thr Ala Ser Tyr Ser  Ala Gly          
        2480                 2485                 2490                  

agg ggc tta  gag ggg aat gct aac  tca cct gcc cac ctg  aga gga      7644
Arg Gly Leu  Glu Gly Asn Ala Asn  Ser Pro Ala His Leu  Arg Gly          
        2495                 2500                 2505                  

cca gaa cag  acg tct ggg cag acg  gct aag gat ccc tct  gtc agc      7689
Pro Glu Gln  Thr Ser Gly Gln Thr  Ala Lys Asp Pro Ser  Val Ser          
        2510                 2515                 2520                  

att cgc tat  ttg gca gca gta aac  acc ggt gct ata aaa  gct gat      7734
Ile Arg Tyr  Leu Ala Ala Val Asn  Thr Gly Ala Ile Lys  Ala Asp          
        2525                 2530                 2535                  

gac atg cca  cct gtt caa ggg acc  gtg gct gag cat tcc  ttt ctt      7779
Asp Met Pro  Pro Val Gln Gly Thr  Val Ala Glu His Ser  Phe Leu          
        2540                 2545                 2550                  

cct gct gag  cag cag ggg tct gaa  gac aac ttg aaa acc  agt acc      7824
Pro Ala Glu  Gln Gln Gly Ser Glu  Asp Asn Leu Lys Thr  Ser Thr          
        2555                 2560                 2565                  

acc aaa tgt  att act ggc caa gaa  tca aaa att gct cct  tcc cac      7869
Thr Lys Cys  Ile Thr Gly Gln Glu  Ser Lys Ile Ala Pro  Ser His          
        2570                 2575                 2580                  

aca atg atc  cct cca gct act tac  agt gta gct ctg ttg  gct cct      7914
Thr Met Ile  Pro Pro Ala Thr Tyr  Ser Val Ala Leu Leu  Ala Pro          
        2585                 2590                 2595                  

aaa tgt gag  cag gac ttg act ata  aag aat gat tat agt  ggc aaa      7959
Lys Cys Glu  Gln Asp Leu Thr Ile  Lys Asn Asp Tyr Ser  Gly Lys          
        2600                 2605                 2610                  

tgg act gat  caa gca tct gct gag  aaa aca gga gat gat  aac agc      8004
Trp Thr Asp  Gln Ala Ser Ala Glu  Lys Thr Gly Asp Asp  Asn Ser          
        2615                 2620                 2625                  

aca agg aaa  tca ttc cct gag gaa  gga gac ata atg gtt  act gtg      8049
Thr Arg Lys  Ser Phe Pro Glu Glu  Gly Asp Ile Met Val  Thr Val          
        2630                 2635                 2640                  

tct tct gaa  gaa aat gtg tgt gac  ata ggc aat gaa gag  tct cca      8094
Ser Ser Glu  Glu Asn Val Cys Asp  Ile Gly Asn Glu Glu  Ser Pro          
        2645                 2650                 2655                  

ttg aat gtt  ttg gga gga ttg aaa  ctg aaa gcc aac ttg  aaa atg      8139
Leu Asn Val  Leu Gly Gly Leu Lys  Leu Lys Ala Asn Leu  Lys Met          
        2660                 2665                 2670                  

gag gct tat  gtg cct tca gag gaa  gag aaa aat ggt gaa  att ctg      8184
Glu Ala Tyr  Val Pro Ser Glu Glu  Glu Lys Asn Gly Glu  Ile Leu          
        2675                 2680                 2685                  

gca cca cca  gaa agt ctg tgt ggg  gga aag cca agt gga  ata gct      8229
Ala Pro Pro  Glu Ser Leu Cys Gly  Gly Lys Pro Ser Gly  Ile Ala          
        2690                 2695                 2700                  

gaa ctc cag  agg gag cct ttg ttg  gtg aat gaa tca cta  aat gtt      8274
Glu Leu Gln  Arg Glu Pro Leu Leu  Val Asn Glu Ser Leu  Asn Val          
        2705                 2710                 2715                  

gaa aat tca  ggc ttc aga aca aat  gaa gaa att cat agc  gaa tct      8319
Glu Asn Ser  Gly Phe Arg Thr Asn  Glu Glu Ile His Ser  Glu Ser          
        2720                 2725                 2730                  

tat aac aaa  gga gag ata tcc agt  ggt aga aaa gac aac  gca gaa      8364
Tyr Asn Lys  Gly Glu Ile Ser Ser  Gly Arg Lys Asp Asn  Ala Glu          
        2735                 2740                 2745                  

gcc ata agc  ggt cac agt gtt gaa  gca gat cct aaa gag  gtt gaa      8409
Ala Ile Ser  Gly His Ser Val Glu  Ala Asp Pro Lys Glu  Val Glu          
        2750                 2755                 2760                  

gag gaa gaa  agg cat atg cct aaa  aga aaa aga aag cag  cat tat      8454
Glu Glu Glu  Arg His Met Pro Lys  Arg Lys Arg Lys Gln  His Tyr          
        2765                 2770                 2775                  

ctc tct tca  gaa gat gaa cca gat  gat aat cca gat gtc  ctg gat      8499
Leu Ser Ser  Glu Asp Glu Pro Asp  Asp Asn Pro Asp Val  Leu Asp          
        2780                 2785                 2790                  

tcc aga ata  gaa aca gca caa agg  cag tgt cct gaa acg  gag cca      8544
Ser Arg Ile  Glu Thr Ala Gln Arg  Gln Cys Pro Glu Thr  Glu Pro          
        2795                 2800                 2805                  

cat gac aca  aag gaa gag aac tcc  aga gat ttg gaa gaa  tta cct      8589
His Asp Thr  Lys Glu Glu Asn Ser  Arg Asp Leu Glu Glu  Leu Pro          
        2810                 2815                 2820                  

aaa acc agt  tct gag aca aat agc  act acc tca agg gtc  atg gaa      8634
Lys Thr Ser  Ser Glu Thr Asn Ser  Thr Thr Ser Arg Val  Met Glu          
        2825                 2830                 2835                  

gaa aaa gat  gaa tat agc agc agt  gaa act act ggt gaa  aag cca      8679
Glu Lys Asp  Glu Tyr Ser Ser Ser  Glu Thr Thr Gly Glu  Lys Pro          
        2840                 2845                 2850                  

gag cag aac  gat gat gac acc ata  aaa tct cag gag gaa  gat cag      8724
Glu Gln Asn  Asp Asp Asp Thr Ile  Lys Ser Gln Glu Glu  Asp Gln          
        2855                 2860                 2865                  

cca ata att  att aaa agg aaa aga  gga aga cct cgc aaa  tac cct      8769
Pro Ile Ile  Ile Lys Arg Lys Arg  Gly Arg Pro Arg Lys  Tyr Pro          
        2870                 2875                 2880                  

gta gaa aca  acg tta aaa atg aaa  gac gac tcc aaa aca  gat act      8814
Val Glu Thr  Thr Leu Lys Met Lys  Asp Asp Ser Lys Thr  Asp Thr          
        2885                 2890                 2895                  

ggc att gtc  act gta gaa caa tct  cca tct agc agc aaa  ctg aaa      8859
Gly Ile Val  Thr Val Glu Gln Ser  Pro Ser Ser Ser Lys  Leu Lys          
        2900                 2905                 2910                  

gta atg caa  aca gat gaa tcc aat  aaa gaa aca gct aac  cta caa      8904
Val Met Gln  Thr Asp Glu Ser Asn  Lys Glu Thr Ala Asn  Leu Gln          
        2915                 2920                 2925                  

gaa aga agt  ata agc aat gat gat  ggt gaa gaa aaa ata  gta aca      8949
Glu Arg Ser  Ile Ser Asn Asp Asp  Gly Glu Glu Lys Ile  Val Thr          
        2930                 2935                 2940                  

agt gtg cgt  cgg aga gga aga aaa  ccc aaa cgt tct ctc  act gta      8994
Ser Val Arg  Arg Arg Gly Arg Lys  Pro Lys Arg Ser Leu  Thr Val          
        2945                 2950                 2955                  

tca gat gat  gct gaa tcc tca gag  cca gaa aga aaa cgc  cag aaa      9039
Ser Asp Asp  Ala Glu Ser Ser Glu  Pro Glu Arg Lys Arg  Gln Lys          
        2960                 2965                 2970                  

tca gtt tct  gat cca gtg gag gac  aag aaa gag cag gag  tct gat      9084
Ser Val Ser  Asp Pro Val Glu Asp  Lys Lys Glu Gln Glu  Ser Asp          
        2975                 2980                 2985                  

gag gaa gag  gaa gaa gag gaa gag  gac gag cct tca gga  gcc acc      9129
Glu Glu Glu  Glu Glu Glu Glu Glu  Asp Glu Pro Ser Gly  Ala Thr          
        2990                 2995                 3000                  

aca aga tcc  acc acc aga tca gag  gct cag aga tca aag  aca cag      9174
Thr Arg Ser  Thr Thr Arg Ser Glu  Ala Gln Arg Ser Lys  Thr Gln          
        3005                 3010                 3015                  

ctc tcc cct  tct atc aag cgc aag  aga gaa gtc agc cct  cct ggg      9219
Leu Ser Pro  Ser Ile Lys Arg Lys  Arg Glu Val Ser Pro  Pro Gly          
        3020                 3025                 3030                  

gcc cga aca  aga ggc cag caa agg  gtg gag gaa gcc cct  gtg aaa      9264
Ala Arg Thr  Arg Gly Gln Gln Arg  Val Glu Glu Ala Pro  Val Lys          
        3035                 3040                 3045                  

aaa gcg aag  cga taa tcctgaccac tgctgcccta ggcttatgga ggaacacggt    9319
Lys Ala Lys  Arg                                                        
        3050                                                            

ggagaggaaa gagacatgcc ttggtggcca taggcttctc tttaaccagg aaaaagatat   9379

gcatgtgctg taagtcccta ggtgcaagct ttttcttgtt atgttttaaa cagctttata   9439

aactattgtt catagaagat attatgtaca tttatttcag ataaaggaca ataagtttac   9499

tttgtatctg aactcaaaac aaagtagttg tatattttaa cattcaaaat tgggatttcc   9559

caatgtgaca catcatgaat gcaaacccct ccagcccatc agacgccagg ctgcctactg   9619

gtaatctgtg tatagtatat aaacatgtaa aaataggttg tattttactc tatgtatgat   9679

gctaatcaat gaacacttta tttattttac agagaaaact tatctgtgaa ctttactata   9739

tatctgttta ttttacttta tttttttttt aaataaaaag ggttttaaat gctatgcagt   9799

cattagtaga aaatttttta ggactctgcc tgctctgtaa ctatcttaat atgatctggc   9859

agaaactcgc atgtatccaa gtaaagtagt ttagctaaag aaaggttctt cattgctttt   9919

ctgttcacag ttgtggctct gttttttaag aatgtaactt gtttttagat tatacttgca   9979

tctgtgactt tactaccagc cacgttgaca caaaacaggt tctggttcag gtaaagttgc  10039

gtcagtcacc tgcagcagaa atccctcttc attcctcttc tctgtgttca ttcctcttct  10099

gtgctgttct gaagcttcta ccaatactct ttccatattg tctttttcag tgaagagaaa  10159

tgcattcaag attaggtccc tcctgtctat ccagtttcag gattttatgt tgttttatac  10219

acagttattt cagtatagaa actggcttta ttgccaagtg tttttttaaa catgttttaa  10279

ctctcatatg agcaaactgt ccaacttcag tttttcataa gattaaactt cttacgatca  10339

aatttgtctc ttgcaatgat gtgatgagtt gccaaataat tgagattatt ttaaaatgtt  10399

ttgttcatat tcttgtttta taattaaaat ttacattcag tgtgtatggg tttttttttt  10459

tattttgact cttaatgtaa ggtggatatt tctgtcattt tacatggttt cttactgaga  10519

ttttatatat aaattataaa atgtttacca aaaaaaaaaa aaaaaaaa               10567


<210>  62
<211>  3051
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ala Thr Asn Pro Gln Pro Gln Pro Pro Pro Pro Ala Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Gln Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro Gly Pro 
            20                  25                  30          


Gly Ala Gly Pro Gly Ala Gly Gly Ala Gly Gly Ala Gly Ala Gly Ala 
        35                  40                  45              


Gly Asp Pro Gln Leu Val Ala Met Ile Val Asn His Leu Lys Ser Gln 
    50                  55                  60                  


Gly Leu Phe Asp Gln Phe Arg Arg Asp Cys Leu Ala Asp Val Asp Thr 
65                  70                  75                  80  


Lys Pro Ala Tyr Gln Asn Leu Arg Gln Arg Val Asp Asn Phe Val Ala 
                85                  90                  95      


Asn His Leu Ala Thr His Thr Trp Ser Pro His Leu Asn Lys Asn Gln 
            100                 105                 110         


Leu Arg Asn Asn Ile Arg Gln Gln Val Leu Lys Ser Gly Met Leu Glu 
        115                 120                 125             


Ser Gly Ile Asp Arg Ile Ile Ser Gln Val Val Asp Pro Lys Ile Asn 
    130                 135                 140                 


His Thr Phe Arg Pro Gln Val Glu Lys Ala Val His Glu Phe Leu Ala 
145                 150                 155                 160 


Thr Leu Asn His Lys Glu Glu Gly Ser Gly Asn Thr Ala Pro Asp Asp 
                165                 170                 175     


Glu Lys Pro Asp Thr Ser Leu Ile Thr Gln Gly Val Pro Thr Pro Gly 
            180                 185                 190         


Pro Ser Ala Asn Val Ala Asn Asp Ala Met Ser Ile Leu Glu Thr Ile 
        195                 200                 205             


Thr Ser Leu Asn Gln Glu Ala Ser Ala Ala Arg Ala Ser Thr Glu Thr 
    210                 215                 220                 


Ser Asn Ala Lys Thr Ser Glu Arg Ala Ser Lys Lys Leu Pro Ser Gln 
225                 230                 235                 240 


Pro Thr Thr Asp Thr Ser Thr Asp Lys Glu Arg Thr Ser Glu Asp Met 
                245                 250                 255     


Ala Asp Lys Glu Lys Ser Thr Ala Asp Ser Gly Gly Glu Gly Leu Glu 
            260                 265                 270         


Thr Ala Pro Lys Ser Glu Glu Phe Ser Asp Leu Pro Cys Pro Val Glu 
        275                 280                 285             


Glu Ile Lys Asn Tyr Thr Lys Glu His Asn Asn Leu Ile Leu Leu Asn 
    290                 295                 300                 


Lys Asp Val Gln Gln Glu Ser Ser Glu Gln Lys Asn Lys Ser Thr Asp 
305                 310                 315                 320 


Lys Gly Glu Lys Lys Pro Asp Ser Asn Glu Lys Gly Glu Arg Lys Lys 
                325                 330                 335     


Glu Lys Lys Glu Lys Thr Glu Lys Lys Phe Asp His Ser Lys Lys Ser 
            340                 345                 350         


Glu Asp Thr Gln Lys Val Lys Asp Glu Lys Gln Ala Lys Glu Lys Glu 
        355                 360                 365             


Val Glu Ser Leu Lys Leu Pro Ser Glu Lys Asn Ser Asn Lys Ala Lys 
    370                 375                 380                 


Thr Val Glu Gly Thr Lys Glu Asp Phe Ser Leu Ile Asp Ser Asp Val 
385                 390                 395                 400 


Asp Gly Leu Thr Asp Ile Thr Val Ser Ser Val His Thr Ser Asp Leu 
                405                 410                 415     


Ser Ser Phe Glu Glu Asp Thr Glu Glu Glu Val Val Thr Ser Asp Ser 
            420                 425                 430         


Met Glu Glu Gly Glu Ile Thr Ser Asp Asp Glu Glu Lys Asn Lys Gln 
        435                 440                 445             


Asn Lys Thr Lys Thr Gln Thr Ser Asp Ser Ser Glu Gly Lys Thr Lys 
    450                 455                 460                 


Ser Val Arg His Ala Tyr Val His Lys Pro Tyr Leu Tyr Ser Lys Tyr 
465                 470                 475                 480 


Tyr Ser Asp Ser Asp Asp Glu Leu Thr Val Glu Gln Arg Arg Gln Ser 
                485                 490                 495     


Ile Ala Lys Glu Lys Glu Glu Arg Leu Leu Arg Arg Gln Ile Asn Arg 
            500                 505                 510         


Glu Lys Leu Glu Glu Lys Arg Lys Gln Lys Ala Glu Lys Thr Lys Ser 
        515                 520                 525             


Ser Lys Thr Lys Gly Gln Gly Arg Ser Ser Val Asp Leu Glu Glu Ser 
    530                 535                 540                 


Ser Thr Lys Ser Leu Glu Pro Lys Ala Ala Arg Ile Lys Glu Val Leu 
545                 550                 555                 560 


Lys Glu Arg Lys Val Leu Glu Lys Lys Val Ala Leu Ser Lys Lys Arg 
                565                 570                 575     


Lys Lys Asp Ser Arg Asn Val Glu Glu Asn Ser Lys Lys Lys Gln Gln 
            580                 585                 590         


Tyr Glu Glu Asp Ser Lys Glu Thr Leu Lys Thr Ser Glu His Cys Glu 
        595                 600                 605             


Lys Glu Lys Ile Ser Ser Ser Lys Glu Leu Lys His Val His Ala Lys 
    610                 615                 620                 


Ser Glu Pro Ser Lys Pro Ala Arg Arg Leu Ser Glu Ser Leu His Val 
625                 630                 635                 640 


Val Asp Glu Asn Lys Asn Glu Ser Lys Ile Glu Arg Glu His Lys Arg 
                645                 650                 655     


Arg Thr Ser Thr Pro Val Ile Met Glu Gly Val Gln Glu Glu Thr Asp 
            660                 665                 670         


Thr Arg Asp Val Lys Arg Gln Val Glu Arg Ser Glu Ile Cys Thr Glu 
        675                 680                 685             


Glu Pro Gln Lys Gln Lys Ser Thr Leu Lys Asn Glu Lys His Leu Lys 
    690                 695                 700                 


Lys Asp Asp Ser Glu Thr Pro His Leu Lys Ser Leu Leu Lys Lys Glu 
705                 710                 715                 720 


Val Lys Ser Ser Lys Glu Lys Pro Glu Arg Glu Lys Thr Pro Ser Glu 
                725                 730                 735     


Asp Lys Leu Ser Val Lys His Lys Tyr Lys Gly Asp Cys Met His Lys 
            740                 745                 750         


Thr Gly Asp Glu Thr Glu Leu His Ser Ser Glu Lys Gly Leu Lys Val 
        755                 760                 765             


Glu Glu Asn Ile Gln Lys Gln Ser Gln Gln Thr Lys Leu Ser Ser Asp 
    770                 775                 780                 


Asp Lys Thr Glu Arg Lys Ser Lys His Arg Asn Glu Arg Lys Leu Ser 
785                 790                 795                 800 


Val Leu Gly Lys Asp Gly Lys Pro Val Ser Glu Tyr Ile Ile Lys Thr 
                805                 810                 815     


Asp Glu Asn Val Arg Lys Glu Asn Asn Lys Lys Glu Arg Arg Leu Ser 
            820                 825                 830         


Ala Glu Lys Thr Lys Ala Glu His Lys Ser Arg Arg Ser Ser Asp Ser 
        835                 840                 845             


Lys Ile Gln Lys Asp Ser Leu Gly Ser Lys Gln His Gly Ile Thr Leu 
    850                 855                 860                 


Gln Arg Arg Ser Glu Ser Tyr Ser Glu Asp Lys Cys Asp Met Asp Ser 
865                 870                 875                 880 


Thr Asn Met Asp Ser Asn Leu Lys Pro Glu Glu Val Val His Lys Glu 
                885                 890                 895     


Lys Arg Arg Thr Lys Ser Leu Leu Glu Glu Lys Leu Val Leu Lys Ser 
            900                 905                 910         


Lys Ser Lys Thr Gln Gly Lys Gln Val Lys Val Val Glu Thr Glu Leu 
        915                 920                 925             


Gln Glu Gly Ala Thr Lys Gln Ala Thr Thr Pro Lys Pro Asp Lys Glu 
    930                 935                 940                 


Lys Asn Thr Glu Glu Asn Asp Ser Glu Lys Gln Arg Lys Ser Lys Val 
945                 950                 955                 960 


Glu Asp Lys Pro Phe Glu Glu Thr Gly Val Glu Pro Val Leu Glu Thr 
                965                 970                 975     


Ala Ser Ser Ser Ala His Ser Thr Gln Lys Asp Ser Ser His Arg Ala 
            980                 985                 990         


Lys Leu Pro Leu Ala Lys Glu Lys  Tyr Lys Ser Asp Lys  Asp Ser Thr 
        995                 1000                 1005             


Ser Thr  Arg Leu Glu Arg Lys  Leu Ser Asp Gly His  Lys Ser Arg 
    1010                 1015                 1020             


Ser Leu  Lys His Ser Ser Lys  Asp Ile Lys Lys Lys  Asp Glu Asn 
    1025                 1030                 1035             


Lys Ser  Asp Asp Lys Asp Gly  Lys Glu Val Asp Ser  Ser His Glu 
    1040                 1045                 1050             


Lys Ala  Arg Gly Asn Ser Ser  Leu Met Glu Lys Lys  Leu Ser Arg 
    1055                 1060                 1065             


Arg Leu  Cys Glu Asn Arg Arg  Gly Ser Leu Ser Gln  Glu Met Ala 
    1070                 1075                 1080             


Lys Gly  Glu Glu Lys Leu Ala  Ala Asn Thr Leu Ser  Thr Pro Ser 
    1085                 1090                 1095             


Gly Ser  Ser Leu Gln Arg Pro  Lys Lys Ser Gly Asp  Met Thr Leu 
    1100                 1105                 1110             


Ile Pro  Glu Gln Glu Pro Met  Glu Ile Asp Ser Glu  Pro Gly Val 
    1115                 1120                 1125             


Glu Asn  Val Phe Glu Val Ser  Lys Thr Gln Asp Asn  Arg Asn Asn 
    1130                 1135                 1140             


Asn Ser  Gln Gln Asp Ile Asp  Ser Glu Asn Met Lys  Gln Lys Thr 
    1145                 1150                 1155             


Ser Ala  Thr Val Gln Lys Asp  Glu Leu Arg Thr Cys  Thr Ala Asp 
    1160                 1165                 1170             


Ser Lys  Ala Thr Ala Pro Ala  Tyr Lys Pro Gly Arg  Gly Thr Gly 
    1175                 1180                 1185             


Val Asn  Ser Asn Ser Glu Lys  His Ala Asp His Arg  Ser Thr Leu 
    1190                 1195                 1200             


Thr Lys  Lys Met His Ile Gln  Ser Ala Val Ser Lys  Met Asn Pro 
    1205                 1210                 1215             


Gly Glu  Lys Glu Pro Ile His  Arg Gly Thr Thr Glu  Val Asn Ile 
    1220                 1225                 1230             


Asp Ser  Glu Thr Val His Arg  Met Leu Leu Ser Ala  Pro Ser Glu 
    1235                 1240                 1245             


Asn Asp  Arg Val Gln Lys Asn  Leu Lys Asn Thr Ala  Ala Glu Glu 
    1250                 1255                 1260             


His Val  Ala Gln Gly Asp Ala  Thr Leu Glu His Ser  Thr Asn Leu 
    1265                 1270                 1275             


Asp Ser  Ser Pro Ser Leu Ser  Ser Val Thr Val Val  Pro Leu Arg 
    1280                 1285                 1290             


Glu Ser  Tyr Asp Pro Asp Val  Ile Pro Leu Phe Asp  Lys Arg Thr 
    1295                 1300                 1305             


Val Leu  Glu Gly Ser Thr Ala  Ser Thr Ser Pro Ala  Asp His Ser 
    1310                 1315                 1320             


Ala Leu  Pro Asn Gln Ser Leu  Thr Val Arg Glu Ser  Glu Val Leu 
    1325                 1330                 1335             


Lys Thr  Ser Asp Ser Lys Glu  Gly Gly Glu Gly Phe  Thr Val Asp 
    1340                 1345                 1350             


Thr Pro  Ala Lys Ala Ser Ile  Thr Ser Lys Arg His  Ile Pro Glu 
    1355                 1360                 1365             


Ala His  Gln Ala Thr Leu Leu  Asp Gly Lys Gln Gly  Lys Val Ile 
    1370                 1375                 1380             


Met Pro  Leu Gly Ser Lys Leu  Thr Gly Val Ile Val  Glu Asn Glu 
    1385                 1390                 1395             


Asn Ile  Thr Lys Glu Gly Gly  Leu Val Asp Met Ala  Lys Lys Glu 
    1400                 1405                 1410             


Asn Asp  Leu Asn Ala Glu Pro  Asn Leu Lys Gln Thr  Ile Lys Ala 
    1415                 1420                 1425             


Thr Val  Glu Asn Gly Lys Lys  Asp Gly Ile Ala Val  Asp His Val 
    1430                 1435                 1440             


Val Gly  Leu Asn Thr Glu Lys  Tyr Ala Glu Thr Val  Lys Leu Lys 
    1445                 1450                 1455             


His Lys  Arg Ser Pro Gly Lys  Val Lys Asp Ile Ser  Ile Asp Val 
    1460                 1465                 1470             


Glu Arg  Arg Asn Glu Asn Ser  Glu Val Asp Thr Ser  Ala Gly Ser 
    1475                 1480                 1485             


Gly Ser  Ala Pro Ser Val Leu  His Gln Arg Asn Gly  Gln Thr Glu 
    1490                 1495                 1500             


Asp Val  Ala Thr Gly Pro Arg  Arg Ala Glu Lys Thr  Ser Val Ala 
    1505                 1510                 1515             


Thr Ser  Thr Glu Gly Lys Asp  Lys Asp Val Thr Leu  Ser Pro Val 
    1520                 1525                 1530             


Lys Ala  Gly Pro Ala Thr Thr  Thr Ser Ser Glu Thr  Arg Gln Ser 
    1535                 1540                 1545             


Glu Val  Ala Leu Pro Cys Thr  Ser Ile Glu Ala Asp  Glu Gly Leu 
    1550                 1555                 1560             


Ile Ile  Gly Thr His Ser Arg  Asn Asn Pro Leu His  Val Gly Ala 
    1565                 1570                 1575             


Glu Ala  Ser Glu Cys Thr Val  Phe Ala Ala Ala Glu  Glu Gly Gly 
    1580                 1585                 1590             


Ala Val  Val Thr Glu Gly Phe  Ala Glu Ser Glu Thr  Phe Leu Thr 
    1595                 1600                 1605             


Ser Thr  Lys Glu Gly Glu Ser  Gly Glu Cys Ala Val  Ala Glu Ser 
    1610                 1615                 1620             


Glu Asp  Arg Ala Ala Asp Leu  Leu Ala Val His Ala  Val Lys Ile 
    1625                 1630                 1635             


Glu Ala  Asn Val Asn Ser Val  Val Thr Glu Glu Lys  Asp Asp Ala 
    1640                 1645                 1650             


Val Thr  Ser Ala Gly Ser Glu  Glu Lys Cys Asp Gly  Ser Leu Ser 
    1655                 1660                 1665             


Arg Asp  Ser Glu Ile Val Glu  Gly Thr Ile Thr Phe  Ile Ser Glu 
    1670                 1675                 1680             


Val Glu  Ser Asp Gly Ala Val  Thr Ser Ala Gly Thr  Glu Ile Arg 
    1685                 1690                 1695             


Ala Gly  Ser Ile Ser Ser Glu  Glu Val Asp Gly Ser  Gln Gly Asn 
    1700                 1705                 1710             


Met Met  Arg Met Gly Pro Lys  Lys Glu Thr Glu Gly  Thr Val Thr 
    1715                 1720                 1725             


Cys Thr  Gly Ala Glu Gly Arg  Ser Asp Asn Phe Val  Ile Cys Ser 
    1730                 1735                 1740             


Val Thr  Gly Ala Gly Pro Arg  Glu Glu Arg Met Val  Thr Gly Ala 
    1745                 1750                 1755             


Gly Val  Val Leu Gly Asp Asn  Asp Ala Pro Pro Gly  Thr Ser Ala 
    1760                 1765                 1770             


Ser Gln  Glu Gly Asp Gly Ser  Val Asn Asp Gly Thr  Glu Gly Glu 
    1775                 1780                 1785             


Ser Ala  Val Thr Ser Thr Gly  Ile Thr Glu Asp Gly  Glu Gly Pro 
    1790                 1795                 1800             


Ala Ser  Cys Thr Gly Ser Glu  Asp Ser Ser Glu Gly  Phe Ala Ile 
    1805                 1810                 1815             


Ser Ser  Glu Ser Glu Glu Asn  Gly Glu Ser Ala Met  Asp Ser Thr 
    1820                 1825                 1830             


Val Ala  Lys Glu Gly Thr Asn  Val Pro Leu Val Ala  Ala Gly Pro 
    1835                 1840                 1845             


Cys Asp  Asp Glu Gly Ile Val  Thr Ser Thr Gly Ala  Lys Glu Glu 
    1850                 1855                 1860             


Asp Glu  Glu Gly Glu Asp Val  Val Thr Ser Thr Gly  Arg Gly Asn 
    1865                 1870                 1875             


Glu Ile  Gly His Ala Ser Thr  Cys Thr Gly Leu Gly  Glu Glu Ser 
    1880                 1885                 1890             


Glu Gly  Val Leu Ile Cys Glu  Ser Ala Glu Gly Asp  Ser Gln Ile 
    1895                 1900                 1905             


Gly Thr  Val Val Glu His Val  Glu Ala Glu Ala Gly  Ala Ala Ile 
    1910                 1915                 1920             


Met Asn  Ala Asn Glu Asn Asn  Val Asp Ser Met Ser  Gly Thr Glu 
    1925                 1930                 1935             


Lys Gly  Ser Lys Asp Thr Asp  Ile Cys Ser Ser Ala  Lys Gly Ile 
    1940                 1945                 1950             


Val Glu  Ser Ser Val Thr Ser  Ala Val Ser Gly Lys  Asp Glu Val 
    1955                 1960                 1965             


Thr Pro  Val Pro Gly Gly Cys  Glu Gly Pro Met Thr  Ser Ala Ala 
    1970                 1975                 1980             


Ser Asp  Gln Ser Asp Ser Gln  Leu Glu Lys Val Glu  Asp Thr Thr 
    1985                 1990                 1995             


Ile Ser  Thr Gly Leu Val Gly  Gly Ser Tyr Asp Val  Leu Val Ser 
    2000                 2005                 2010             


Gly Glu  Val Pro Glu Cys Glu  Val Ala His Thr Ser  Pro Ser Glu 
    2015                 2020                 2025             


Lys Glu  Asp Glu Asp Ile Ile  Thr Ser Val Glu Asn  Glu Glu Cys 
    2030                 2035                 2040             


Asp Gly  Leu Met Ala Thr Thr  Ala Ser Gly Asp Ile  Thr Asn Gln 
    2045                 2050                 2055             


Asn Ser  Leu Ala Gly Gly Lys  Asn Gln Gly Lys Val  Leu Ile Ile 
    2060                 2065                 2070             


Ser Thr  Ser Thr Thr Asn Asp  Tyr Thr Pro Gln Val  Ser Ala Ile 
    2075                 2080                 2085             


Thr Asp  Val Glu Gly Gly Leu  Ser Asp Ala Leu Arg  Thr Glu Glu 
    2090                 2095                 2100             


Asn Met  Glu Gly Thr Arg Val  Thr Thr Glu Glu Phe  Glu Ala Pro 
    2105                 2110                 2115             


Met Pro  Ser Ala Val Ser Gly  Asp Asp Ser Gln Leu  Thr Ala Ser 
    2120                 2125                 2130             


Arg Ser  Glu Glu Lys Asp Glu  Cys Ala Met Ile Ser  Thr Ser Ile 
    2135                 2140                 2145             


Gly Glu  Glu Phe Glu Leu Pro  Ile Ser Ser Ala Thr  Thr Ile Lys 
    2150                 2155                 2160             


Cys Ala  Glu Ser Leu Gln Pro  Val Ala Ala Ala Val  Glu Glu Arg 
    2165                 2170                 2175             


Ala Thr  Gly Pro Val Leu Ile  Ser Thr Ala Asp Phe  Glu Gly Pro 
    2180                 2185                 2190             


Met Pro  Ser Ala Pro Pro Glu  Ala Glu Ser Pro Leu  Ala Ser Thr 
    2195                 2200                 2205             


Ser Lys  Glu Glu Lys Asp Glu  Cys Ala Leu Ile Ser  Thr Ser Ile 
    2210                 2215                 2220             


Ala Glu  Glu Cys Glu Ala Ser  Val Ser Gly Val Val  Val Glu Ser 
    2225                 2230                 2235             


Glu Asn  Glu Arg Ala Gly Thr  Val Met Glu Glu Lys  Asp Gly Ser 
    2240                 2245                 2250             


Gly Ile  Ile Ser Thr Ser Ser  Val Glu Asp Cys Glu  Gly Pro Val 
    2255                 2260                 2265             


Ser Ser  Ala Val Pro Gln Glu  Glu Gly Asp Pro Ser  Val Thr Pro 
    2270                 2275                 2280             


Ala Glu  Glu Met Gly Asp Thr  Ala Met Ile Ser Thr  Ser Thr Ser 
    2285                 2290                 2295             


Glu Gly  Cys Glu Ala Val Met  Ile Gly Ala Val Leu  Gln Asp Glu 
    2300                 2305                 2310             


Asp Arg  Leu Thr Ile Thr Arg  Val Glu Asp Leu Ser  Asp Ala Ala 
    2315                 2320                 2325             


Ile Ile  Ser Thr Ser Thr Ala  Glu Cys Met Pro Ile  Ser Ala Ser 
    2330                 2335                 2340             


Ile Asp  Arg His Glu Glu Asn  Gln Leu Thr Ala Asp  Asn Pro Glu 
    2345                 2350                 2355             


Gly Asn  Gly Asp Leu Ser Ala  Thr Glu Val Ser Lys  His Lys Val 
    2360                 2365                 2370             


Pro Met  Pro Ser Leu Ile Ala  Glu Asn Asn Cys Arg  Cys Pro Gly 
    2375                 2380                 2385             


Pro Val  Arg Gly Gly Lys Glu  Pro Gly Pro Val Leu  Ala Val Ser 
    2390                 2395                 2400             


Thr Glu  Glu Gly His Asn Gly  Pro Ser Val His Lys  Pro Ser Ala 
    2405                 2410                 2415             


Gly Gln  Gly His Pro Ser Ala  Val Cys Ala Glu Lys  Glu Glu Lys 
    2420                 2425                 2430             


His Gly  Lys Glu Cys Pro Glu  Ile Gly Pro Phe Ala  Gly Arg Gly 
    2435                 2440                 2445             


Gln Lys  Glu Ser Thr Leu His  Leu Ile Asn Ala Glu  Glu Lys Asn 
    2450                 2455                 2460             


Val Leu  Leu Asn Ser Leu Gln  Lys Glu Asp Lys Ser  Pro Glu Thr 
    2465                 2470                 2475             


Gly Thr  Ala Gly Gly Ser Ser  Thr Ala Ser Tyr Ser  Ala Gly Arg 
    2480                 2485                 2490             


Gly Leu  Glu Gly Asn Ala Asn  Ser Pro Ala His Leu  Arg Gly Pro 
    2495                 2500                 2505             


Glu Gln  Thr Ser Gly Gln Thr  Ala Lys Asp Pro Ser  Val Ser Ile 
    2510                 2515                 2520             


Arg Tyr  Leu Ala Ala Val Asn  Thr Gly Ala Ile Lys  Ala Asp Asp 
    2525                 2530                 2535             


Met Pro  Pro Val Gln Gly Thr  Val Ala Glu His Ser  Phe Leu Pro 
    2540                 2545                 2550             


Ala Glu  Gln Gln Gly Ser Glu  Asp Asn Leu Lys Thr  Ser Thr Thr 
    2555                 2560                 2565             


Lys Cys  Ile Thr Gly Gln Glu  Ser Lys Ile Ala Pro  Ser His Thr 
    2570                 2575                 2580             


Met Ile  Pro Pro Ala Thr Tyr  Ser Val Ala Leu Leu  Ala Pro Lys 
    2585                 2590                 2595             


Cys Glu  Gln Asp Leu Thr Ile  Lys Asn Asp Tyr Ser  Gly Lys Trp 
    2600                 2605                 2610             


Thr Asp  Gln Ala Ser Ala Glu  Lys Thr Gly Asp Asp  Asn Ser Thr 
    2615                 2620                 2625             


Arg Lys  Ser Phe Pro Glu Glu  Gly Asp Ile Met Val  Thr Val Ser 
    2630                 2635                 2640             


Ser Glu  Glu Asn Val Cys Asp  Ile Gly Asn Glu Glu  Ser Pro Leu 
    2645                 2650                 2655             


Asn Val  Leu Gly Gly Leu Lys  Leu Lys Ala Asn Leu  Lys Met Glu 
    2660                 2665                 2670             


Ala Tyr  Val Pro Ser Glu Glu  Glu Lys Asn Gly Glu  Ile Leu Ala 
    2675                 2680                 2685             


Pro Pro  Glu Ser Leu Cys Gly  Gly Lys Pro Ser Gly  Ile Ala Glu 
    2690                 2695                 2700             


Leu Gln  Arg Glu Pro Leu Leu  Val Asn Glu Ser Leu  Asn Val Glu 
    2705                 2710                 2715             


Asn Ser  Gly Phe Arg Thr Asn  Glu Glu Ile His Ser  Glu Ser Tyr 
    2720                 2725                 2730             


Asn Lys  Gly Glu Ile Ser Ser  Gly Arg Lys Asp Asn  Ala Glu Ala 
    2735                 2740                 2745             


Ile Ser  Gly His Ser Val Glu  Ala Asp Pro Lys Glu  Val Glu Glu 
    2750                 2755                 2760             


Glu Glu  Arg His Met Pro Lys  Arg Lys Arg Lys Gln  His Tyr Leu 
    2765                 2770                 2775             


Ser Ser  Glu Asp Glu Pro Asp  Asp Asn Pro Asp Val  Leu Asp Ser 
    2780                 2785                 2790             


Arg Ile  Glu Thr Ala Gln Arg  Gln Cys Pro Glu Thr  Glu Pro His 
    2795                 2800                 2805             


Asp Thr  Lys Glu Glu Asn Ser  Arg Asp Leu Glu Glu  Leu Pro Lys 
    2810                 2815                 2820             


Thr Ser  Ser Glu Thr Asn Ser  Thr Thr Ser Arg Val  Met Glu Glu 
    2825                 2830                 2835             


Lys Asp  Glu Tyr Ser Ser Ser  Glu Thr Thr Gly Glu  Lys Pro Glu 
    2840                 2845                 2850             


Gln Asn  Asp Asp Asp Thr Ile  Lys Ser Gln Glu Glu  Asp Gln Pro 
    2855                 2860                 2865             


Ile Ile  Ile Lys Arg Lys Arg  Gly Arg Pro Arg Lys  Tyr Pro Val 
    2870                 2875                 2880             


Glu Thr  Thr Leu Lys Met Lys  Asp Asp Ser Lys Thr  Asp Thr Gly 
    2885                 2890                 2895             


Ile Val  Thr Val Glu Gln Ser  Pro Ser Ser Ser Lys  Leu Lys Val 
    2900                 2905                 2910             


Met Gln  Thr Asp Glu Ser Asn  Lys Glu Thr Ala Asn  Leu Gln Glu 
    2915                 2920                 2925             


Arg Ser  Ile Ser Asn Asp Asp  Gly Glu Glu Lys Ile  Val Thr Ser 
    2930                 2935                 2940             


Val Arg  Arg Arg Gly Arg Lys  Pro Lys Arg Ser Leu  Thr Val Ser 
    2945                 2950                 2955             


Asp Asp  Ala Glu Ser Ser Glu  Pro Glu Arg Lys Arg  Gln Lys Ser 
    2960                 2965                 2970             


Val Ser  Asp Pro Val Glu Asp  Lys Lys Glu Gln Glu  Ser Asp Glu 
    2975                 2980                 2985             


Glu Glu  Glu Glu Glu Glu Glu  Asp Glu Pro Ser Gly  Ala Thr Thr 
    2990                 2995                 3000             


Arg Ser  Thr Thr Arg Ser Glu  Ala Gln Arg Ser Lys  Thr Gln Leu 
    3005                 3010                 3015             


Ser Pro  Ser Ile Lys Arg Lys  Arg Glu Val Ser Pro  Pro Gly Ala 
    3020                 3025                 3030             


Arg Thr  Arg Gly Gln Gln Arg  Val Glu Glu Ala Pro  Val Lys Lys 
    3035                 3040                 3045             


Ala Lys  Arg 
    3050     


<210>  63
<211>  2416
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (156)..(950)
<223>  

<400>  63
ccacgaccaa tgatatgaaa tacaacgatg gtttttcata tcattggtcg tggctgtagt     60

ccgtgcgaga ataatgatgt atgctttgtt tctgttgagt gtgggcgctt gccccggggg    120

tctgtcgcgt cgcaggcgcc gccggagccc tggcc atg agg acc ctg tgg atg       173
                                       Met Arg Thr Leu Trp Met          
                                       1               5                

gcg ctg tgc gcg ctg tcg cgg ctg tgg ccc ggg gcc cag gcc ggc tgc      221
Ala Leu Cys Ala Leu Ser Arg Leu Trp Pro Gly Ala Gln Ala Gly Cys         
            10                  15                  20                  

gcc gag gcc ggg cgc tgc tgt ccc ggc cgg gac ccc gcc tgc ttc gcc      269
Ala Glu Ala Gly Arg Cys Cys Pro Gly Arg Asp Pro Ala Cys Phe Ala         
        25                  30                  35                      

cgc ggc tgg agg ctg gac agg gtc tac ggg acg tgt ttc tgc gac caa      317
Arg Gly Trp Arg Leu Asp Arg Val Tyr Gly Thr Cys Phe Cys Asp Gln         
    40                  45                  50                          

gcc tgt cgc ttc acc ggg gac tgc tgc ttc gac tac gac agg gcg tgc      365
Ala Cys Arg Phe Thr Gly Asp Cys Cys Phe Asp Tyr Asp Arg Ala Cys         
55                  60                  65                  70          

cca gct cgc ccg tgc ttc gtg ggg gaa tgg agc ccc tgg agt ggt tgt      413
Pro Ala Arg Pro Cys Phe Val Gly Glu Trp Ser Pro Trp Ser Gly Cys         
                75                  80                  85              

gca gac cag tgc aag cct aca acc cgt gtg cgg agg cgc tcg gtg cag      461
Ala Asp Gln Cys Lys Pro Thr Thr Arg Val Arg Arg Arg Ser Val Gln         
            90                  95                  100                 

cag gag cct cag aac ggc ggg gcg ccc tgc cca ccc ctg gaa gag aga      509
Gln Glu Pro Gln Asn Gly Gly Ala Pro Cys Pro Pro Leu Glu Glu Arg         
        105                 110                 115                     

gct ggc tgc ctg gag tac tcc acc ccg cag ggc cag gac tgc ggg cac      557
Ala Gly Cys Leu Glu Tyr Ser Thr Pro Gln Gly Gln Asp Cys Gly His         
    120                 125                 130                         

acc tat gtt cct gcc ttt ata act acc tct gca ttc aac aag gag aga      605
Thr Tyr Val Pro Ala Phe Ile Thr Thr Ser Ala Phe Asn Lys Glu Arg         
135                 140                 145                 150         

aca cga caa gct acg tct cca cac tgg tct aca cac aca gag gat gct      653
Thr Arg Gln Ala Thr Ser Pro His Trp Ser Thr His Thr Glu Asp Ala         
                155                 160                 165             

gga tac tgt atg gag ttt aag aca gag tcc ttg act cct cac tgt gct      701
Gly Tyr Cys Met Glu Phe Lys Thr Glu Ser Leu Thr Pro His Cys Ala         
            170                 175                 180                 

ctg gaa aac tgg ccc ttg act aga tgg atg cag tat ctc cga gag gga      749
Leu Glu Asn Trp Pro Leu Thr Arg Trp Met Gln Tyr Leu Arg Glu Gly         
        185                 190                 195                     

tac acg gtg tgt gtg gat tgt cag cct cca gct atg aac tct gtg agc      797
Tyr Thr Val Cys Val Asp Cys Gln Pro Pro Ala Met Asn Ser Val Ser         
    200                 205                 210                         

ctt cgt tgt tct gga gat ggc ctg gac tcc gat gga aat cag act ctc      845
Leu Arg Cys Ser Gly Asp Gly Leu Asp Ser Asp Gly Asn Gln Thr Leu         
215                 220                 225                 230         

cat tgg caa gca att ggt aat cct cgg tgt caa gga act tgg aaa aaa      893
His Trp Gln Ala Ile Gly Asn Pro Arg Cys Gln Gly Thr Trp Lys Lys         
                235                 240                 245             

gtt cgg cga gta gac cag tgt tct tgt cca gct gtt cac agt ttt att      941
Val Arg Arg Val Asp Gln Cys Ser Cys Pro Ala Val His Ser Phe Ile         
            250                 255                 260                 

ttt ata tag atggtgatat aaatatttcc aaatgcattt gtaaacattc              990
Phe Ile                                                                 
                                                                        

taaatattct caagtcatgt tcaatgtttc ctaaaccttc aattttggcc aaagtcccca   1050

aacacatcat tgccacactc tgaagtagag aaagaaaatt taggggccag ttctcaagga   1110

acacaggtcc tttattttta ttttaactaa gttgaagacc cactcaaaaa gctcttgtgg   1170

ttttatgttc ttgacctttc aactggagtc ctctcattca gcaggtggcc cgtgagacac   1230

agaatacatg tctgtttgct aaagtaaaat tactgtaact cagtccgatt attggtgacg   1290

gaagtgtcat ttaaggggat ctatgttttg aaccttgcag tctattttat aatcttttaa   1350

aagtttctca ctttaaaaca tgtatacagg tatgcacact ctacacatat atttccatat   1410

atttaatatt ccataaattc tgaaataatt tcaagcaaat tatcacaaat aatttttcca   1470

cagggcaaat tatttaaaat tttagtaagc attctgtaat gaaaaaccaa gttatactaa   1530

aaacattttt tgaagaagaa attttttttt ttgcttaaga agtgaaagga tcaaatgctc   1590

attgtaggtc aatgggagtt cttttaaatg ttataatttt catgaaaaga aatgttgaca   1650

ccagtgaatg aaacaattgc tttcattctg aaaattctac caccatttgc atctaagatt   1710

atttccaagg cttaaagcct gaagctgaat aaaataatct ttcagagtcc agcttcaagt   1770

ttagttgatg taagctcact atttttttcc taccgcatgc attttctaat gtttggggtg   1830

gatggtgtgt cggttatgga aggcatagac gtcattacag gtgctacgat ctcacacaca   1890

cacaaggaaa tgttagtctc cttattttat gattggaaaa tcaatgacct agaggcaaaa   1950

tggcatgttt aaggacctgg gatgacaagt cattctgcag tcagccacag agccaaattt   2010

ggactcctca accagaactc catgaaaagc ctgactttgc caaacactgt gctggaaaag   2070

ctaagcccct ttcatttgtg aagtaaattt taaattcaag atatttagtt tagagaattg   2130

agtcttgaga tgtaaactac atgagatttc tttggtttca attgaataat attcactaac   2190

aaatgattta ctaaaatacg tatttcttgg tccttatcat gtaatgacag attcacaaca   2250

gcaataagga tggagatttc cccaataatt aataacaccg agagtagcaa tattttttac   2310

tgtattttca tttaattgtc aaagttgttt ttgtggaaaa ttaaattctt cagaaattaa   2370

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                  2416


<210>  64
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Arg Thr Leu Trp Met Ala Leu Cys Ala Leu Ser Arg Leu Trp Pro 
1               5                   10                  15      


Gly Ala Gln Ala Gly Cys Ala Glu Ala Gly Arg Cys Cys Pro Gly Arg 
            20                  25                  30          


Asp Pro Ala Cys Phe Ala Arg Gly Trp Arg Leu Asp Arg Val Tyr Gly 
        35                  40                  45              


Thr Cys Phe Cys Asp Gln Ala Cys Arg Phe Thr Gly Asp Cys Cys Phe 
    50                  55                  60                  


Asp Tyr Asp Arg Ala Cys Pro Ala Arg Pro Cys Phe Val Gly Glu Trp 
65                  70                  75                  80  


Ser Pro Trp Ser Gly Cys Ala Asp Gln Cys Lys Pro Thr Thr Arg Val 
                85                  90                  95      


Arg Arg Arg Ser Val Gln Gln Glu Pro Gln Asn Gly Gly Ala Pro Cys 
            100                 105                 110         


Pro Pro Leu Glu Glu Arg Ala Gly Cys Leu Glu Tyr Ser Thr Pro Gln 
        115                 120                 125             


Gly Gln Asp Cys Gly His Thr Tyr Val Pro Ala Phe Ile Thr Thr Ser 
    130                 135                 140                 


Ala Phe Asn Lys Glu Arg Thr Arg Gln Ala Thr Ser Pro His Trp Ser 
145                 150                 155                 160 


Thr His Thr Glu Asp Ala Gly Tyr Cys Met Glu Phe Lys Thr Glu Ser 
                165                 170                 175     


Leu Thr Pro His Cys Ala Leu Glu Asn Trp Pro Leu Thr Arg Trp Met 
            180                 185                 190         


Gln Tyr Leu Arg Glu Gly Tyr Thr Val Cys Val Asp Cys Gln Pro Pro 
        195                 200                 205             


Ala Met Asn Ser Val Ser Leu Arg Cys Ser Gly Asp Gly Leu Asp Ser 
    210                 215                 220                 


Asp Gly Asn Gln Thr Leu His Trp Gln Ala Ile Gly Asn Pro Arg Cys 
225                 230                 235                 240 


Gln Gly Thr Trp Lys Lys Val Arg Arg Val Asp Gln Cys Ser Cys Pro 
                245                 250                 255     


Ala Val His Ser Phe Ile Phe Ile 
            260                 


<210>  65
<211>  4372
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (78)..(1922)
<223>  

<400>  65
cagtcctcga ccccccgcac ctcgcccctt ccccaccccc tcctccgcct cggtgcccgg     60

cgctgctccg gaccact atg acc atg aga tcc gcg gtg ttc aag gcg gcc       110
                   Met Thr Met Arg Ser Ala Val Phe Lys Ala Ala          
                   1               5                   10               

gcg gcc cct gcc ggc ggc aat cct gag cag cga ctg gac tac gag cgg      158
Ala Ala Pro Ala Gly Gly Asn Pro Glu Gln Arg Leu Asp Tyr Glu Arg         
            15                  20                  25                  

gct gcg gcg ctg ggc ggg ccc gag gac gag cct ggg gcg gcc gaa gcc      206
Ala Ala Ala Leu Gly Gly Pro Glu Asp Glu Pro Gly Ala Ala Glu Ala         
        30                  35                  40                      

cac ttc ctc ccc cgg cac cgt aag ctc aag gag ccg ggg ccc ccg ctg      254
His Phe Leu Pro Arg His Arg Lys Leu Lys Glu Pro Gly Pro Pro Leu         
    45                  50                  55                          

gcc tcc tcc cag ggc ggg agc ccc gcg cct tcc ccg gcc ggc tgc ggc      302
Ala Ser Ser Gln Gly Gly Ser Pro Ala Pro Ser Pro Ala Gly Cys Gly         
60                  65                  70                  75          

ggc aag ggc cgg ggc ttg tta ctc ccg gcc ggg gcg gcc ccc ggg cag      350
Gly Lys Gly Arg Gly Leu Leu Leu Pro Ala Gly Ala Ala Pro Gly Gln         
                80                  85                  90              

cag gaa gag agc tgg ggc ggt tcg gtg ccc ttg ccc tgt ccg ccc ccg      398
Gln Glu Glu Ser Trp Gly Gly Ser Val Pro Leu Pro Cys Pro Pro Pro         
            95                  100                 105                 

gcc acc aag caa gcc ggc att ggg ggg gag cct gcc gca gcc gga gcc      446
Ala Thr Lys Gln Ala Gly Ile Gly Gly Glu Pro Ala Ala Ala Gly Ala         
        110                 115                 120                     

ggc tgc agc ccc cgg ccc aag tat cag gcg gtg ctg ccc att cag acg      494
Gly Cys Ser Pro Arg Pro Lys Tyr Gln Ala Val Leu Pro Ile Gln Thr         
    125                 130                 135                         

ggc tct ctc gtg gcg gcg gcc aaa gag cct acg ccc tgg gct ggg gac      542
Gly Ser Leu Val Ala Ala Ala Lys Glu Pro Thr Pro Trp Ala Gly Asp         
140                 145                 150                 155         

aag ggt ggg gcg gcc tcc ccc gct gcc acc gcc tcg gac ccg gcg gga      590
Lys Gly Gly Ala Ala Ser Pro Ala Ala Thr Ala Ser Asp Pro Ala Gly         
                160                 165                 170             

ccc cca cca cta cct ctg ccc ggg ccg cca ccc ctc gcg ccc acc gcc      638
Pro Pro Pro Leu Pro Leu Pro Gly Pro Pro Pro Leu Ala Pro Thr Ala         
            175                 180                 185                 

acc gcc ggg acc ctg gcg gcc agc gag ggc aga tgg aag agt atg agg      686
Thr Ala Gly Thr Leu Ala Ala Ser Glu Gly Arg Trp Lys Ser Met Arg         
        190                 195                 200                     

aag agc cct ctc ggg ggt ggt ggc ggc tcg gga gcc tcc agt cag gcc      734
Lys Ser Pro Leu Gly Gly Gly Gly Gly Ser Gly Ala Ser Ser Gln Ala         
    205                 210                 215                         

gcc tgc ctc aaa cag atc ctt ctg ctg caa ttg gac ctc atc gaa cag      782
Ala Cys Leu Lys Gln Ile Leu Leu Leu Gln Leu Asp Leu Ile Glu Gln         
220                 225                 230                 235         

cag cag cag cag ctg cag gcc aag gaa aag gag atc gag gag ctg aag      830
Gln Gln Gln Gln Leu Gln Ala Lys Glu Lys Glu Ile Glu Glu Leu Lys         
                240                 245                 250             

tca gag aga gac acg ctc ctt gct cgg att gaa cgt atg gaa agg cgg      878
Ser Glu Arg Asp Thr Leu Leu Ala Arg Ile Glu Arg Met Glu Arg Arg         
            255                 260                 265                 

atg cag ctg gta aag aag gat aac gag aaa gaa agg cac aag ctg ttt      926
Met Gln Leu Val Lys Lys Asp Asn Glu Lys Glu Arg His Lys Leu Phe         
        270                 275                 280                     

cag ggc tat gaa act gaa gag aga gag gaa aca gag cta tct gag aaa      974
Gln Gly Tyr Glu Thr Glu Glu Arg Glu Glu Thr Glu Leu Ser Glu Lys         
    285                 290                 295                         

att aaa ctg gag tgc cag ccg gag ctt tcc gag aca tcc cag act ctg     1022
Ile Lys Leu Glu Cys Gln Pro Glu Leu Ser Glu Thr Ser Gln Thr Leu         
300                 305                 310                 315         

cct ccc aag ccc ttc tca tgt ggg cgg agt gga aag gga cat aaa agg     1070
Pro Pro Lys Pro Phe Ser Cys Gly Arg Ser Gly Lys Gly His Lys Arg         
                320                 325                 330             

aaa tcc cca ttt gga agt aca gaa aga aag act cct gtt aaa aag ctg     1118
Lys Ser Pro Phe Gly Ser Thr Glu Arg Lys Thr Pro Val Lys Lys Leu         
            335                 340                 345                 

gct cct gaa ttt tca aaa gtc aaa aca aaa act cct aag cac tct cct     1166
Ala Pro Glu Phe Ser Lys Val Lys Thr Lys Thr Pro Lys His Ser Pro         
        350                 355                 360                     

att aaa gag gaa ccc tgt ggt tcc tta tct gaa act gtt tgt aaa cgt     1214
Ile Lys Glu Glu Pro Cys Gly Ser Leu Ser Glu Thr Val Cys Lys Arg         
    365                 370                 375                         

gaa ttg agg agc caa gaa acc cca gaa aag ccc cgg tct tca gtg gac     1262
Glu Leu Arg Ser Gln Glu Thr Pro Glu Lys Pro Arg Ser Ser Val Asp         
380                 385                 390                 395         

acc cca cca aga ctc tcc act ccc caa aag gga ccc agc acc cat ccc     1310
Thr Pro Pro Arg Leu Ser Thr Pro Gln Lys Gly Pro Ser Thr His Pro         
                400                 405                 410             

aag gag aaa gcc ttc tca agt gag ata gaa gat ttg ccg tac ctt tcc     1358
Lys Glu Lys Ala Phe Ser Ser Glu Ile Glu Asp Leu Pro Tyr Leu Ser         
            415                 420                 425                 

acc aca gaa atg tat ttg tgt cgt tgg cac cag cct ccc cca tca ccg     1406
Thr Thr Glu Met Tyr Leu Cys Arg Trp His Gln Pro Pro Pro Ser Pro         
        430                 435                 440                     

tta cca tta cgg gaa tcc tct cca aag aag gag gag act gta gca agg     1454
Leu Pro Leu Arg Glu Ser Ser Pro Lys Lys Glu Glu Thr Val Ala Arg         
    445                 450                 455                         

tgt ctg atg cca tca agt gtt gca gga gaa act tca gtc ttg gct gtt     1502
Cys Leu Met Pro Ser Ser Val Ala Gly Glu Thr Ser Val Leu Ala Val         
460                 465                 470                 475         

cct tct tgg agg gac cac tca gta gag cct cta agg gac cca aat cct     1550
Pro Ser Trp Arg Asp His Ser Val Glu Pro Leu Arg Asp Pro Asn Pro         
                480                 485                 490             

tca gac ctt ttg gag aac ctg gat gac agt gtg ttt tcg aag cgg cat     1598
Ser Asp Leu Leu Glu Asn Leu Asp Asp Ser Val Phe Ser Lys Arg His         
            495                 500                 505                 

gca aaa ctg gag ctg gat gag aag aga agg aaa aga tgg gat att cag     1646
Ala Lys Leu Glu Leu Asp Glu Lys Arg Arg Lys Arg Trp Asp Ile Gln         
        510                 515                 520                     

agg atc agg gaa caa aga att tta cag cga ctg cag ctc aga atg tat     1694
Arg Ile Arg Glu Gln Arg Ile Leu Gln Arg Leu Gln Leu Arg Met Tyr         
    525                 530                 535                         

aaa aag aaa gga att cag gaa tct gag cct gag gtt acc tca ttt ttc     1742
Lys Lys Lys Gly Ile Gln Glu Ser Glu Pro Glu Val Thr Ser Phe Phe         
540                 545                 550                 555         

cct gag cca gat gat gtt gaa agt ttg atg att acc ccc ttc ttg cct     1790
Pro Glu Pro Asp Asp Val Glu Ser Leu Met Ile Thr Pro Phe Leu Pro         
                560                 565                 570             

gtt gta gca ttt gga cga cca tta cca aaa tta act cca cag aat ttt     1838
Val Val Ala Phe Gly Arg Pro Leu Pro Lys Leu Thr Pro Gln Asn Phe         
            575                 580                 585                 

gag cta ccc tgg ttg gat gag cgt agc cga tgc aga ttg gag atc cag     1886
Glu Leu Pro Trp Leu Asp Glu Arg Ser Arg Cys Arg Leu Glu Ile Gln         
        590                 595                 600                     

aag aag caa aca cct cac cgg acg tgt agg aaa tag ctgtgctggc          1932
Lys Lys Gln Thr Pro His Arg Thr Cys Arg Lys                             
    605                 610                                             

aagaaccctg tcttcagata gttgtagcat gccattcccg agagtggcag agacctgtat   1992

atgtgacctt tgtcctcaca tatgttatca ctcgctgata ataccctttc atacttcctt   2052

gactttgttt tcattactct gatttcacaa aaactctttc attcggctaa ttgtgagtta   2112

tggagggtga ttgggatttc ttttcccttt tttgggaaat gggctctcaa gctaaagcta   2172

taggatggca gattcagaag tttcaggggt ctgtttctat acatttgcct atgttaaagg   2232

ggtaaaaggg ctctcttcat tagacatgtg gaagatgaag cagccccttc ctttagagct   2292

gtgcctgcat ggcactcttc tcaccctggt acaccctcct tatagtgggt atagtgattt   2352

ttaaccctaa aataaaacaa acaacctcac catgagcttt aggaccagaa gaggaatgac   2412

aagtgaagcg atgaagcaag ccatcttcac agagtagaaa agacatcgga gagttggtag   2472

ataactgtct gaaaagatag ttgttcattt gaaactattc tgtgatacag tcatgtggga   2532

agggatgttt ggctgtgatt attttttcag ttaatggata acaatttctt tactgctcaa   2592

aaaccaaaat ctttggaaaa gaaagtgggg atggttagtt tcagaacaag ttacagctgt   2652

aaacaaaagc acttagtatt tgggatggca tgccaaaacc tgtataaatg tccttgtatc   2712

acatcacttc tcaagtattc cttcattggg cttcatcctt ttagcagaac tcttggtggt   2772

gggatagaga cttagggagg gtagggggag agtgtggaaa taggtgcttc ctttggctgg   2832

caaatgtcta catcttgaaa caaacagatg tacctaatga gcttctccat tcactttgta   2892

aaaataattt gtatgtgtac catcttggtc ctctcccctc ccgttttgtt aaaatatcag   2952

gatagcactc ccaggccact ttggtctcag tgtaagatcc ctattaacta tctgaaagga   3012

aaatagagcc aagacctctg gtctcaaata tataggaatt gcctttcttt agtcttcagg   3072

actattgtgt gaaaacaagt aggggtctaa tctcctagaa ggtaggggct tttatcctta   3132

aagagaatat gtccccagat tattagcact tttagaggag aagccaaggt atgtagggtg   3192

tgtggctggc ccatcagtgg agcacgaaga gagaatggga taccattgtg ggaagagaag   3252

aaaagttcct caggggcctc ccactgctaa agttttttgt gagatgttga tctgtgcttc   3312

ctggatttga cttttaaagg aattattctg gcagcacatg tagtattctt ggatgatctt   3372

gctgctctta tttctccttt tgtgtgtgtg tgtgtgtgtg tgtggctatg ggttttcatt   3432

tgtaactcca tctgcttagg agagtgggct ctctataagg gaacctgctg taaacttcat   3492

tgcagcaagg atgtagagag aaataggact taattccact aggggctctc atctcacacc   3552

ttaaggagga gatttctaga aaaactgggc cagattttct ttgttctcca tcattttaat   3612

gtggcaggct gttcagtttt cttactctta cctatgtgat atttcttcgt aacgtgtcca   3672

aaaagaaaaa agacccaatc agtgtctctt gactttgttc tttgatccct cagtttcttc   3732

ttgatttcag catgtgtcgg gttcctaatt ttgggtatga gttagcaaat ttaaccattg   3792

tgtttgtgcc ctacccaggg gactccccag tttctgactt gaagtagact gagaagaatc   3852

cacgaggtgc tatctggcca gatttaagta gattctattt ccttggttct ccctctccct   3912

gaggacctct tattttattg tcccctcttc taggttaatt ctcctttgat ttgactttgt   3972

tgagaaggag gttggacagt agattagcaa agttccaagt gcaaaattac agtgtgttag   4032

agtgtggggg gaaaattagt cttatttttc cctacatggg atacaacact gtgaattcaa   4092

tcttcaactg aaggccctgc agttctccta aaacatagtt gtttgttttt ctttaacaaa   4152

gtttaagcta gtgttaataa attaaaaaaa attgcttgtc tgtctacttc agctttgttt   4212

tatgcccatt tcatattgtt gtctgtgttg taattcataa cttttgatac catttctgat   4272

gtgtaaaatt ggttgtcttg taaatatctt ataaagagtt caattgtaaa taaactattg   4332

tggctgttaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                         4372


<210>  66
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Thr Met Arg Ser Ala Val Phe Lys Ala Ala Ala Ala Pro Ala Gly 
1               5                   10                  15      


Gly Asn Pro Glu Gln Arg Leu Asp Tyr Glu Arg Ala Ala Ala Leu Gly 
            20                  25                  30          


Gly Pro Glu Asp Glu Pro Gly Ala Ala Glu Ala His Phe Leu Pro Arg 
        35                  40                  45              


His Arg Lys Leu Lys Glu Pro Gly Pro Pro Leu Ala Ser Ser Gln Gly 
    50                  55                  60                  


Gly Ser Pro Ala Pro Ser Pro Ala Gly Cys Gly Gly Lys Gly Arg Gly 
65                  70                  75                  80  


Leu Leu Leu Pro Ala Gly Ala Ala Pro Gly Gln Gln Glu Glu Ser Trp 
                85                  90                  95      


Gly Gly Ser Val Pro Leu Pro Cys Pro Pro Pro Ala Thr Lys Gln Ala 
            100                 105                 110         


Gly Ile Gly Gly Glu Pro Ala Ala Ala Gly Ala Gly Cys Ser Pro Arg 
        115                 120                 125             


Pro Lys Tyr Gln Ala Val Leu Pro Ile Gln Thr Gly Ser Leu Val Ala 
    130                 135                 140                 


Ala Ala Lys Glu Pro Thr Pro Trp Ala Gly Asp Lys Gly Gly Ala Ala 
145                 150                 155                 160 


Ser Pro Ala Ala Thr Ala Ser Asp Pro Ala Gly Pro Pro Pro Leu Pro 
                165                 170                 175     


Leu Pro Gly Pro Pro Pro Leu Ala Pro Thr Ala Thr Ala Gly Thr Leu 
            180                 185                 190         


Ala Ala Ser Glu Gly Arg Trp Lys Ser Met Arg Lys Ser Pro Leu Gly 
        195                 200                 205             


Gly Gly Gly Gly Ser Gly Ala Ser Ser Gln Ala Ala Cys Leu Lys Gln 
    210                 215                 220                 


Ile Leu Leu Leu Gln Leu Asp Leu Ile Glu Gln Gln Gln Gln Gln Leu 
225                 230                 235                 240 


Gln Ala Lys Glu Lys Glu Ile Glu Glu Leu Lys Ser Glu Arg Asp Thr 
                245                 250                 255     


Leu Leu Ala Arg Ile Glu Arg Met Glu Arg Arg Met Gln Leu Val Lys 
            260                 265                 270         


Lys Asp Asn Glu Lys Glu Arg His Lys Leu Phe Gln Gly Tyr Glu Thr 
        275                 280                 285             


Glu Glu Arg Glu Glu Thr Glu Leu Ser Glu Lys Ile Lys Leu Glu Cys 
    290                 295                 300                 


Gln Pro Glu Leu Ser Glu Thr Ser Gln Thr Leu Pro Pro Lys Pro Phe 
305                 310                 315                 320 


Ser Cys Gly Arg Ser Gly Lys Gly His Lys Arg Lys Ser Pro Phe Gly 
                325                 330                 335     


Ser Thr Glu Arg Lys Thr Pro Val Lys Lys Leu Ala Pro Glu Phe Ser 
            340                 345                 350         


Lys Val Lys Thr Lys Thr Pro Lys His Ser Pro Ile Lys Glu Glu Pro 
        355                 360                 365             


Cys Gly Ser Leu Ser Glu Thr Val Cys Lys Arg Glu Leu Arg Ser Gln 
    370                 375                 380                 


Glu Thr Pro Glu Lys Pro Arg Ser Ser Val Asp Thr Pro Pro Arg Leu 
385                 390                 395                 400 


Ser Thr Pro Gln Lys Gly Pro Ser Thr His Pro Lys Glu Lys Ala Phe 
                405                 410                 415     


Ser Ser Glu Ile Glu Asp Leu Pro Tyr Leu Ser Thr Thr Glu Met Tyr 
            420                 425                 430         


Leu Cys Arg Trp His Gln Pro Pro Pro Ser Pro Leu Pro Leu Arg Glu 
        435                 440                 445             


Ser Ser Pro Lys Lys Glu Glu Thr Val Ala Arg Cys Leu Met Pro Ser 
    450                 455                 460                 


Ser Val Ala Gly Glu Thr Ser Val Leu Ala Val Pro Ser Trp Arg Asp 
465                 470                 475                 480 


His Ser Val Glu Pro Leu Arg Asp Pro Asn Pro Ser Asp Leu Leu Glu 
                485                 490                 495     


Asn Leu Asp Asp Ser Val Phe Ser Lys Arg His Ala Lys Leu Glu Leu 
            500                 505                 510         


Asp Glu Lys Arg Arg Lys Arg Trp Asp Ile Gln Arg Ile Arg Glu Gln 
        515                 520                 525             


Arg Ile Leu Gln Arg Leu Gln Leu Arg Met Tyr Lys Lys Lys Gly Ile 
    530                 535                 540                 


Gln Glu Ser Glu Pro Glu Val Thr Ser Phe Phe Pro Glu Pro Asp Asp 
545                 550                 555                 560 


Val Glu Ser Leu Met Ile Thr Pro Phe Leu Pro Val Val Ala Phe Gly 
                565                 570                 575     


Arg Pro Leu Pro Lys Leu Thr Pro Gln Asn Phe Glu Leu Pro Trp Leu 
            580                 585                 590         


Asp Glu Arg Ser Arg Cys Arg Leu Glu Ile Gln Lys Lys Gln Thr Pro 
        595                 600                 605             


His Arg Thr Cys Arg Lys 
    610                 


<210>  67
<211>  2179
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (169)..(1917)
<223>  

<400>  67
caagctctaa tacgactcac tatagggaaa gctggtacgc ctgcaggtac cggtccggaa     60

ttcccgggtc gacccacgcg tccggccgag agaagcagta gtcaataaag agagtgccgt    120

atttcgcaga ttggagctga gctgtggctg ccagaagata gcgaacga atg gaa act     177
                                                     Met Glu Thr        
                                                     1                  

gaa agt gga aat cag gaa aag gta atg gaa gaa gaa agc act gaa aag      225
Glu Ser Gly Asn Gln Glu Lys Val Met Glu Glu Glu Ser Thr Glu Lys         
    5                   10                  15                          

aaa aaa gaa gtt gaa aaa aag aaa cgg tca cga gtt aaa cag gtg ctt      273
Lys Lys Glu Val Glu Lys Lys Lys Arg Ser Arg Val Lys Gln Val Leu         
20                  25                  30                  35          

gca gat att gct aag caa gtg gac ttc tgg ttt ggg gat gca aat ctt      321
Ala Asp Ile Ala Lys Gln Val Asp Phe Trp Phe Gly Asp Ala Asn Leu         
                40                  45                  50              

cac aag gat aga ttt ctt cga gaa cag ata gaa aaa tct aga gat gga      369
His Lys Asp Arg Phe Leu Arg Glu Gln Ile Glu Lys Ser Arg Asp Gly         
            55                  60                  65                  

tat gtt gat ata tca cta ctt gtg tct ttt aac aaa atg aaa aaa ttg      417
Tyr Val Asp Ile Ser Leu Leu Val Ser Phe Asn Lys Met Lys Lys Leu         
        70                  75                  80                      

act act gat ggg aag tta att gcc aga gca ttg aga agt tca gct gtt      465
Thr Thr Asp Gly Lys Leu Ile Ala Arg Ala Leu Arg Ser Ser Ala Val         
    85                  90                  95                          

gta gag ctt gat ttg gaa ggc acc aga atc cgg agg aaa aaa cct ctg      513
Val Glu Leu Asp Leu Glu Gly Thr Arg Ile Arg Arg Lys Lys Pro Leu         
100                 105                 110                 115         

ggg gaa aga cca aag gat gag gat gaa cgc aca gtg tat gtg gag tta      561
Gly Glu Arg Pro Lys Asp Glu Asp Glu Arg Thr Val Tyr Val Glu Leu         
                120                 125                 130             

ctt ccc aaa aat gtt aat cac agc tgg att gaa aga gta ttt ggg aaa      609
Leu Pro Lys Asn Val Asn His Ser Trp Ile Glu Arg Val Phe Gly Lys         
            135                 140                 145                 

tgt ggc aat gtt gtt tat ata agt ata cca cat tat aag tct act gga      657
Cys Gly Asn Val Val Tyr Ile Ser Ile Pro His Tyr Lys Ser Thr Gly         
        150                 155                 160                     

gat cca aag ggg ttt gcg ttt gtg gaa ttt gaa aca aaa gaa caa gca      705
Asp Pro Lys Gly Phe Ala Phe Val Glu Phe Glu Thr Lys Glu Gln Ala         
    165                 170                 175                         

gca aaa gca att gag ttt ctt aac aac cca cca gaa gaa gca cca aga      753
Ala Lys Ala Ile Glu Phe Leu Asn Asn Pro Pro Glu Glu Ala Pro Arg         
180                 185                 190                 195         

aaa cct ggc ata ttt cct aaa aca gtg aaa aat aag ccc att cca gcc      801
Lys Pro Gly Ile Phe Pro Lys Thr Val Lys Asn Lys Pro Ile Pro Ala         
                200                 205                 210             

tta aga gtt gtg gaa gag aag aaa aag aaa aag aag aag aaa ggc aga      849
Leu Arg Val Val Glu Glu Lys Lys Lys Lys Lys Lys Lys Lys Gly Arg         
            215                 220                 225                 

atg aaa aag gaa gac aat atc caa gcc aaa gaa gaa aac atg gac aca      897
Met Lys Lys Glu Asp Asn Ile Gln Ala Lys Glu Glu Asn Met Asp Thr         
        230                 235                 240                     

agc aac acc agc atc acc aaa atg aaa aga tcc aga ccc aca tct gag      945
Ser Asn Thr Ser Ile Thr Lys Met Lys Arg Ser Arg Pro Thr Ser Glu         
    245                 250                 255                         

ggc tct gac att gag tcc act gaa ccc caa aag cag tgc tca aag aaa      993
Gly Ser Asp Ile Glu Ser Thr Glu Pro Gln Lys Gln Cys Ser Lys Lys         
260                 265                 270                 275         

aag aaa aaa cgg gac aga gtt gaa gca tct agc tta cct gaa gtc aga     1041
Lys Lys Lys Arg Asp Arg Val Glu Ala Ser Ser Leu Pro Glu Val Arg         
                280                 285                 290             

aca ggg aag agg aag aga agc agc tct gaa gat gca gaa tcc cta gct     1089
Thr Gly Lys Arg Lys Arg Ser Ser Ser Glu Asp Ala Glu Ser Leu Ala         
            295                 300                 305                 

ccc cga tca aaa gta aag aaa att att cag aaa gac atc att aag gaa     1137
Pro Arg Ser Lys Val Lys Lys Ile Ile Gln Lys Asp Ile Ile Lys Glu         
        310                 315                 320                     

gca tca gaa gct tcc aag gaa aat aga gat ata gaa atc tct act gaa     1185
Ala Ser Glu Ala Ser Lys Glu Asn Arg Asp Ile Glu Ile Ser Thr Glu         
    325                 330                 335                         

gag gaa aag gat act gga gat cta aaa gat agc tct ctc ttg aaa aca     1233
Glu Glu Lys Asp Thr Gly Asp Leu Lys Asp Ser Ser Leu Leu Lys Thr         
340                 345                 350                 355         

aaa agg aaa cat aag aaa aaa cat aaa gag aga cat aaa atg gga gaa     1281
Lys Arg Lys His Lys Lys Lys His Lys Glu Arg His Lys Met Gly Glu         
                360                 365                 370             

gaa gtt ata cca tta aga gtg cta tca aag agc gaa tgg atg gat ttg     1329
Glu Val Ile Pro Leu Arg Val Leu Ser Lys Ser Glu Trp Met Asp Leu         
            375                 380                 385                 

aaa aaa gag tat tta gcg cta caa aaa gct agc atg gct tct tta aaa     1377
Lys Lys Glu Tyr Leu Ala Leu Gln Lys Ala Ser Met Ala Ser Leu Lys         
        390                 395                 400                     

aaa aca ata tcc caa ata aaa tca gag tca gaa atg gaa aca gac agt     1425
Lys Thr Ile Ser Gln Ile Lys Ser Glu Ser Glu Met Glu Thr Asp Ser         
    405                 410                 415                         

gga gta cct caa aac act gga atg aaa aat gaa aaa aca gcc aac agg     1473
Gly Val Pro Gln Asn Thr Gly Met Lys Asn Glu Lys Thr Ala Asn Arg         
420                 425                 430                 435         

gaa gag tgt cgc acc cag gag aaa gtt aat gca aca gga cca cag ttc     1521
Glu Glu Cys Arg Thr Gln Glu Lys Val Asn Ala Thr Gly Pro Gln Phe         
                440                 445                 450             

gtg agt gga gtg att gtg aag atc att agc aca gag cct cta cct ggc     1569
Val Ser Gly Val Ile Val Lys Ile Ile Ser Thr Glu Pro Leu Pro Gly         
            455                 460                 465                 

agg aaa caa gtc cgg gat act ttg gca gca atc tca gaa gtt ctt tat     1617
Arg Lys Gln Val Arg Asp Thr Leu Ala Ala Ile Ser Glu Val Leu Tyr         
        470                 475                 480                     

gtt gat ttg cta gaa ggg gat aca gaa tgc cat gct aga ttt aag act     1665
Val Asp Leu Leu Glu Gly Asp Thr Glu Cys His Ala Arg Phe Lys Thr         
    485                 490                 495                         

cct gag gat gct caa gca gta ata aat gcc tat aca gaa att aac aag     1713
Pro Glu Asp Ala Gln Ala Val Ile Asn Ala Tyr Thr Glu Ile Asn Lys         
500                 505                 510                 515         

gaa cac tgc tgg aaa ctc gag atc ctt tct ggt gat cac gaa caa agg     1761
Glu His Cys Trp Lys Leu Glu Ile Leu Ser Gly Asp His Glu Gln Arg         
                520                 525                 530             

tat tgg cag aag att ttg gtt gat aga cag gca aaa ctt aat cag cct     1809
Tyr Trp Gln Lys Ile Leu Val Asp Arg Gln Ala Lys Leu Asn Gln Pro         
            535                 540                 545                 

cgg gaa aag aaa aga ggc act gaa aag tta atc acc aaa gct gaa aag     1857
Arg Glu Lys Lys Arg Gly Thr Glu Lys Leu Ile Thr Lys Ala Glu Lys         
        550                 555                 560                     

att aga ctg gca aag act caa caa gcg agt aaa cat ata aga ttt tct     1905
Ile Arg Leu Ala Lys Thr Gln Gln Ala Ser Lys His Ile Arg Phe Ser         
    565                 570                 575                         

gaa tat gat tga aaaaaaaaac agttcacctc ttaatacttc acaagatact         1957
Glu Tyr Asp                                                             
580                                                                     

tgagctgttc ttgggagatt cacttttatt atggtagcac tgcataatta atgtgttttt   2017

aattaaaaga aatatctttg ttccttaact tgtaaataag acttttttct agagacaaat   2077

atgatgtata ccacaatttt tcttaaacat tttatttgtt gaaattatct tagatgtcag   2137

tgtcaggtga tttagtaaat aaatgtgttt tgaacattaa aa                      2179


<210>  68
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Glu Thr Glu Ser Gly Asn Gln Glu Lys Val Met Glu Glu Glu Ser 
1               5                   10                  15      


Thr Glu Lys Lys Lys Glu Val Glu Lys Lys Lys Arg Ser Arg Val Lys 
            20                  25                  30          


Gln Val Leu Ala Asp Ile Ala Lys Gln Val Asp Phe Trp Phe Gly Asp 
        35                  40                  45              


Ala Asn Leu His Lys Asp Arg Phe Leu Arg Glu Gln Ile Glu Lys Ser 
    50                  55                  60                  


Arg Asp Gly Tyr Val Asp Ile Ser Leu Leu Val Ser Phe Asn Lys Met 
65                  70                  75                  80  


Lys Lys Leu Thr Thr Asp Gly Lys Leu Ile Ala Arg Ala Leu Arg Ser 
                85                  90                  95      


Ser Ala Val Val Glu Leu Asp Leu Glu Gly Thr Arg Ile Arg Arg Lys 
            100                 105                 110         


Lys Pro Leu Gly Glu Arg Pro Lys Asp Glu Asp Glu Arg Thr Val Tyr 
        115                 120                 125             


Val Glu Leu Leu Pro Lys Asn Val Asn His Ser Trp Ile Glu Arg Val 
    130                 135                 140                 


Phe Gly Lys Cys Gly Asn Val Val Tyr Ile Ser Ile Pro His Tyr Lys 
145                 150                 155                 160 


Ser Thr Gly Asp Pro Lys Gly Phe Ala Phe Val Glu Phe Glu Thr Lys 
                165                 170                 175     


Glu Gln Ala Ala Lys Ala Ile Glu Phe Leu Asn Asn Pro Pro Glu Glu 
            180                 185                 190         


Ala Pro Arg Lys Pro Gly Ile Phe Pro Lys Thr Val Lys Asn Lys Pro 
        195                 200                 205             


Ile Pro Ala Leu Arg Val Val Glu Glu Lys Lys Lys Lys Lys Lys Lys 
    210                 215                 220                 


Lys Gly Arg Met Lys Lys Glu Asp Asn Ile Gln Ala Lys Glu Glu Asn 
225                 230                 235                 240 


Met Asp Thr Ser Asn Thr Ser Ile Thr Lys Met Lys Arg Ser Arg Pro 
                245                 250                 255     


Thr Ser Glu Gly Ser Asp Ile Glu Ser Thr Glu Pro Gln Lys Gln Cys 
            260                 265                 270         


Ser Lys Lys Lys Lys Lys Arg Asp Arg Val Glu Ala Ser Ser Leu Pro 
        275                 280                 285             


Glu Val Arg Thr Gly Lys Arg Lys Arg Ser Ser Ser Glu Asp Ala Glu 
    290                 295                 300                 


Ser Leu Ala Pro Arg Ser Lys Val Lys Lys Ile Ile Gln Lys Asp Ile 
305                 310                 315                 320 


Ile Lys Glu Ala Ser Glu Ala Ser Lys Glu Asn Arg Asp Ile Glu Ile 
                325                 330                 335     


Ser Thr Glu Glu Glu Lys Asp Thr Gly Asp Leu Lys Asp Ser Ser Leu 
            340                 345                 350         


Leu Lys Thr Lys Arg Lys His Lys Lys Lys His Lys Glu Arg His Lys 
        355                 360                 365             


Met Gly Glu Glu Val Ile Pro Leu Arg Val Leu Ser Lys Ser Glu Trp 
    370                 375                 380                 


Met Asp Leu Lys Lys Glu Tyr Leu Ala Leu Gln Lys Ala Ser Met Ala 
385                 390                 395                 400 


Ser Leu Lys Lys Thr Ile Ser Gln Ile Lys Ser Glu Ser Glu Met Glu 
                405                 410                 415     


Thr Asp Ser Gly Val Pro Gln Asn Thr Gly Met Lys Asn Glu Lys Thr 
            420                 425                 430         


Ala Asn Arg Glu Glu Cys Arg Thr Gln Glu Lys Val Asn Ala Thr Gly 
        435                 440                 445             


Pro Gln Phe Val Ser Gly Val Ile Val Lys Ile Ile Ser Thr Glu Pro 
    450                 455                 460                 


Leu Pro Gly Arg Lys Gln Val Arg Asp Thr Leu Ala Ala Ile Ser Glu 
465                 470                 475                 480 


Val Leu Tyr Val Asp Leu Leu Glu Gly Asp Thr Glu Cys His Ala Arg 
                485                 490                 495     


Phe Lys Thr Pro Glu Asp Ala Gln Ala Val Ile Asn Ala Tyr Thr Glu 
            500                 505                 510         


Ile Asn Lys Glu His Cys Trp Lys Leu Glu Ile Leu Ser Gly Asp His 
        515                 520                 525             


Glu Gln Arg Tyr Trp Gln Lys Ile Leu Val Asp Arg Gln Ala Lys Leu 
    530                 535                 540                 


Asn Gln Pro Arg Glu Lys Lys Arg Gly Thr Glu Lys Leu Ile Thr Lys 
545                 550                 555                 560 


Ala Glu Lys Ile Arg Leu Ala Lys Thr Gln Gln Ala Ser Lys His Ile 
                565                 570                 575     


Arg Phe Ser Glu Tyr Asp 
            580         


<210>  69
<211>  2060
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (50)..(1798)
<223>  

<400>  69
gtccgaaggc cgcagtactt gaccctgtat tttgggagtc gaacggaga atg gaa act     58
                                                      Met Glu Thr       
                                                      1                 

gaa agt gga aat cag gaa aag gta atg gaa gaa gaa agc act gaa aag      106
Glu Ser Gly Asn Gln Glu Lys Val Met Glu Glu Glu Ser Thr Glu Lys         
    5                   10                  15                          

aaa aaa gaa gtt gaa aaa aag aaa cgg tca cga gtt aaa cag gtg ctt      154
Lys Lys Glu Val Glu Lys Lys Lys Arg Ser Arg Val Lys Gln Val Leu         
20                  25                  30                  35          

gca gat att gct aag caa gtg gac ttc tgg ttt ggg gat gca aat ctt      202
Ala Asp Ile Ala Lys Gln Val Asp Phe Trp Phe Gly Asp Ala Asn Leu         
                40                  45                  50              

cac aag gat aga ttt ctt cga gaa cag ata gaa aaa tct aga gat gga      250
His Lys Asp Arg Phe Leu Arg Glu Gln Ile Glu Lys Ser Arg Asp Gly         
            55                  60                  65                  

tat gtt gat ata tca cta ctt gtg tct ttt aac aaa atg aaa aaa ttg      298
Tyr Val Asp Ile Ser Leu Leu Val Ser Phe Asn Lys Met Lys Lys Leu         
        70                  75                  80                      

act act gat ggg aag tta att gcc aga gca ttg aga agt tca gct gtt      346
Thr Thr Asp Gly Lys Leu Ile Ala Arg Ala Leu Arg Ser Ser Ala Val         
    85                  90                  95                          

gta gag ctt gat ttg gaa ggc acc aga atc cgg agg aaa aaa cct ctg      394
Val Glu Leu Asp Leu Glu Gly Thr Arg Ile Arg Arg Lys Lys Pro Leu         
100                 105                 110                 115         

ggg gaa aga cca aag gat gag gat gaa cgc aca gtg tat gtg gag tta      442
Gly Glu Arg Pro Lys Asp Glu Asp Glu Arg Thr Val Tyr Val Glu Leu         
                120                 125                 130             

ctt ccc aaa aat gtt aat cac agc tgg att gaa aga gta ttt ggg aaa      490
Leu Pro Lys Asn Val Asn His Ser Trp Ile Glu Arg Val Phe Gly Lys         
            135                 140                 145                 

tgt ggc aat gtt gtt tat ata agt ata cca cat tat aag tct act gga      538
Cys Gly Asn Val Val Tyr Ile Ser Ile Pro His Tyr Lys Ser Thr Gly         
        150                 155                 160                     

gat cca aag ggg ttt gcg ttt gtg gaa ttt gaa aca aaa gaa caa gca      586
Asp Pro Lys Gly Phe Ala Phe Val Glu Phe Glu Thr Lys Glu Gln Ala         
    165                 170                 175                         

gca aaa gca att gag ttt ctt aac aac cca cca gaa gaa gca cca aga      634
Ala Lys Ala Ile Glu Phe Leu Asn Asn Pro Pro Glu Glu Ala Pro Arg         
180                 185                 190                 195         

aaa cct ggc ata ttt cct aaa aca gtg aaa aat aag ccc att cca gcc      682
Lys Pro Gly Ile Phe Pro Lys Thr Val Lys Asn Lys Pro Ile Pro Ala         
                200                 205                 210             

tta aga gtt gtg gaa gag aag aaa aag aaa aag aag aag aaa ggc aga      730
Leu Arg Val Val Glu Glu Lys Lys Lys Lys Lys Lys Lys Lys Gly Arg         
            215                 220                 225                 

atg aaa aag gaa gac aat atc caa gcc aaa gaa gaa aac atg gac aca      778
Met Lys Lys Glu Asp Asn Ile Gln Ala Lys Glu Glu Asn Met Asp Thr         
        230                 235                 240                     

agc aac acc agc atc acc aaa atg aaa aga tcc aga ccc aca tct gag      826
Ser Asn Thr Ser Ile Thr Lys Met Lys Arg Ser Arg Pro Thr Ser Glu         
    245                 250                 255                         

ggc tct gac att gag tcc act gaa ccc caa aag cag tgc tca aag aaa      874
Gly Ser Asp Ile Glu Ser Thr Glu Pro Gln Lys Gln Cys Ser Lys Lys         
260                 265                 270                 275         

aag aaa aaa cgg gac aga gtt gaa gca tct agc tta cct gaa gtc aga      922
Lys Lys Lys Arg Asp Arg Val Glu Ala Ser Ser Leu Pro Glu Val Arg         
                280                 285                 290             

aca ggg aag agg aag aga agc agc tct gaa gat gca gaa tcc cta gct      970
Thr Gly Lys Arg Lys Arg Ser Ser Ser Glu Asp Ala Glu Ser Leu Ala         
            295                 300                 305                 

ccc cga tca aaa gta aag aaa att att cag aaa gac atc att aag gaa     1018
Pro Arg Ser Lys Val Lys Lys Ile Ile Gln Lys Asp Ile Ile Lys Glu         
        310                 315                 320                     

gca tca gaa gct tcc aag gaa aat aga gat ata gaa atc tct act gaa     1066
Ala Ser Glu Ala Ser Lys Glu Asn Arg Asp Ile Glu Ile Ser Thr Glu         
    325                 330                 335                         

gag gaa aag gat act gga gat cta aaa gat agc tct ctc ttg aaa aca     1114
Glu Glu Lys Asp Thr Gly Asp Leu Lys Asp Ser Ser Leu Leu Lys Thr         
340                 345                 350                 355         

aaa agg aaa cat aag aaa aaa cat aaa gag aga cat aaa atg gga gaa     1162
Lys Arg Lys His Lys Lys Lys His Lys Glu Arg His Lys Met Gly Glu         
                360                 365                 370             

gaa gtt ata cca tta aga gtg cta tca aag agc gaa tgg atg gat ttg     1210
Glu Val Ile Pro Leu Arg Val Leu Ser Lys Ser Glu Trp Met Asp Leu         
            375                 380                 385                 

aaa aaa gag tat tta gcg cta caa aaa gct agc atg gct tct tta aaa     1258
Lys Lys Glu Tyr Leu Ala Leu Gln Lys Ala Ser Met Ala Ser Leu Lys         
        390                 395                 400                     

aaa aca ata tcc caa ata aaa tca gag tca gaa atg gaa aca gac agt     1306
Lys Thr Ile Ser Gln Ile Lys Ser Glu Ser Glu Met Glu Thr Asp Ser         
    405                 410                 415                         

gga gta cct caa aac act gga atg aaa aat gaa aaa aca gcc aac agg     1354
Gly Val Pro Gln Asn Thr Gly Met Lys Asn Glu Lys Thr Ala Asn Arg         
420                 425                 430                 435         

gaa gag tgt cgc acc cag gag aaa gtt aat gca aca gga cca cag ttc     1402
Glu Glu Cys Arg Thr Gln Glu Lys Val Asn Ala Thr Gly Pro Gln Phe         
                440                 445                 450             

gtg agt gga gtg att gtg aag atc att agc aca gag cct cta cct ggc     1450
Val Ser Gly Val Ile Val Lys Ile Ile Ser Thr Glu Pro Leu Pro Gly         
            455                 460                 465                 

agg aaa caa gtc cgg gat act ttg gca gca atc tca gaa gtt ctt tat     1498
Arg Lys Gln Val Arg Asp Thr Leu Ala Ala Ile Ser Glu Val Leu Tyr         
        470                 475                 480                     

gtt gat ttg cta gaa ggg gat aca gaa tgc cat gct aga ttt aag act     1546
Val Asp Leu Leu Glu Gly Asp Thr Glu Cys His Ala Arg Phe Lys Thr         
    485                 490                 495                         

cct gag gat gct caa gca gta ata aat gcc tat aca gaa att aac aag     1594
Pro Glu Asp Ala Gln Ala Val Ile Asn Ala Tyr Thr Glu Ile Asn Lys         
500                 505                 510                 515         

gaa cac tgc tgg aaa ctc gag atc ctt tct ggt gat cac gaa caa agg     1642
Glu His Cys Trp Lys Leu Glu Ile Leu Ser Gly Asp His Glu Gln Arg         
                520                 525                 530             

tat tgg cag aag att ttg gtt gat aga cag gca aaa ctt aat cag cct     1690
Tyr Trp Gln Lys Ile Leu Val Asp Arg Gln Ala Lys Leu Asn Gln Pro         
            535                 540                 545                 

cgg gaa aag aaa aga ggc act gaa aag tta atc acc aaa gct gaa aag     1738
Arg Glu Lys Lys Arg Gly Thr Glu Lys Leu Ile Thr Lys Ala Glu Lys         
        550                 555                 560                     

att aga ctg gca aag act caa caa gcg agt aaa cat ata aga ttt tct     1786
Ile Arg Leu Ala Lys Thr Gln Gln Ala Ser Lys His Ile Arg Phe Ser         
    565                 570                 575                         

gaa tat gat tga aaaaaaaaac agttcacctc ttaatacttc acaagatact         1838
Glu Tyr Asp                                                             
580                                                                     

tgagctgttc ttgggagatt cacttttatt atggtagcac tgcataatta atgtgttttt   1898

aattaaaaga aatatctttg ttccttaact tgtaaataag acttttttct agagacaaat   1958

atgatgtata ccacaatttt tcttaaacat tttatttgtt gaaattatct tagatgtcag   2018

tgtcaggtga tttagtaaat aaatgtgttt tgaacattaa aa                      2060


<210>  70
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Glu Thr Glu Ser Gly Asn Gln Glu Lys Val Met Glu Glu Glu Ser 
1               5                   10                  15      


Thr Glu Lys Lys Lys Glu Val Glu Lys Lys Lys Arg Ser Arg Val Lys 
            20                  25                  30          


Gln Val Leu Ala Asp Ile Ala Lys Gln Val Asp Phe Trp Phe Gly Asp 
        35                  40                  45              


Ala Asn Leu His Lys Asp Arg Phe Leu Arg Glu Gln Ile Glu Lys Ser 
    50                  55                  60                  


Arg Asp Gly Tyr Val Asp Ile Ser Leu Leu Val Ser Phe Asn Lys Met 
65                  70                  75                  80  


Lys Lys Leu Thr Thr Asp Gly Lys Leu Ile Ala Arg Ala Leu Arg Ser 
                85                  90                  95      


Ser Ala Val Val Glu Leu Asp Leu Glu Gly Thr Arg Ile Arg Arg Lys 
            100                 105                 110         


Lys Pro Leu Gly Glu Arg Pro Lys Asp Glu Asp Glu Arg Thr Val Tyr 
        115                 120                 125             


Val Glu Leu Leu Pro Lys Asn Val Asn His Ser Trp Ile Glu Arg Val 
    130                 135                 140                 


Phe Gly Lys Cys Gly Asn Val Val Tyr Ile Ser Ile Pro His Tyr Lys 
145                 150                 155                 160 


Ser Thr Gly Asp Pro Lys Gly Phe Ala Phe Val Glu Phe Glu Thr Lys 
                165                 170                 175     


Glu Gln Ala Ala Lys Ala Ile Glu Phe Leu Asn Asn Pro Pro Glu Glu 
            180                 185                 190         


Ala Pro Arg Lys Pro Gly Ile Phe Pro Lys Thr Val Lys Asn Lys Pro 
        195                 200                 205             


Ile Pro Ala Leu Arg Val Val Glu Glu Lys Lys Lys Lys Lys Lys Lys 
    210                 215                 220                 


Lys Gly Arg Met Lys Lys Glu Asp Asn Ile Gln Ala Lys Glu Glu Asn 
225                 230                 235                 240 


Met Asp Thr Ser Asn Thr Ser Ile Thr Lys Met Lys Arg Ser Arg Pro 
                245                 250                 255     


Thr Ser Glu Gly Ser Asp Ile Glu Ser Thr Glu Pro Gln Lys Gln Cys 
            260                 265                 270         


Ser Lys Lys Lys Lys Lys Arg Asp Arg Val Glu Ala Ser Ser Leu Pro 
        275                 280                 285             


Glu Val Arg Thr Gly Lys Arg Lys Arg Ser Ser Ser Glu Asp Ala Glu 
    290                 295                 300                 


Ser Leu Ala Pro Arg Ser Lys Val Lys Lys Ile Ile Gln Lys Asp Ile 
305                 310                 315                 320 


Ile Lys Glu Ala Ser Glu Ala Ser Lys Glu Asn Arg Asp Ile Glu Ile 
                325                 330                 335     


Ser Thr Glu Glu Glu Lys Asp Thr Gly Asp Leu Lys Asp Ser Ser Leu 
            340                 345                 350         


Leu Lys Thr Lys Arg Lys His Lys Lys Lys His Lys Glu Arg His Lys 
        355                 360                 365             


Met Gly Glu Glu Val Ile Pro Leu Arg Val Leu Ser Lys Ser Glu Trp 
    370                 375                 380                 


Met Asp Leu Lys Lys Glu Tyr Leu Ala Leu Gln Lys Ala Ser Met Ala 
385                 390                 395                 400 


Ser Leu Lys Lys Thr Ile Ser Gln Ile Lys Ser Glu Ser Glu Met Glu 
                405                 410                 415     


Thr Asp Ser Gly Val Pro Gln Asn Thr Gly Met Lys Asn Glu Lys Thr 
            420                 425                 430         


Ala Asn Arg Glu Glu Cys Arg Thr Gln Glu Lys Val Asn Ala Thr Gly 
        435                 440                 445             


Pro Gln Phe Val Ser Gly Val Ile Val Lys Ile Ile Ser Thr Glu Pro 
    450                 455                 460                 


Leu Pro Gly Arg Lys Gln Val Arg Asp Thr Leu Ala Ala Ile Ser Glu 
465                 470                 475                 480 


Val Leu Tyr Val Asp Leu Leu Glu Gly Asp Thr Glu Cys His Ala Arg 
                485                 490                 495     


Phe Lys Thr Pro Glu Asp Ala Gln Ala Val Ile Asn Ala Tyr Thr Glu 
            500                 505                 510         


Ile Asn Lys Glu His Cys Trp Lys Leu Glu Ile Leu Ser Gly Asp His 
        515                 520                 525             


Glu Gln Arg Tyr Trp Gln Lys Ile Leu Val Asp Arg Gln Ala Lys Leu 
    530                 535                 540                 


Asn Gln Pro Arg Glu Lys Lys Arg Gly Thr Glu Lys Leu Ile Thr Lys 
545                 550                 555                 560 


Ala Glu Lys Ile Arg Leu Ala Lys Thr Gln Gln Ala Ser Lys His Ile 
                565                 570                 575     


Arg Phe Ser Glu Tyr Asp 
            580         


<210>  71
<211>  8426
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (261)..(7391)
<223>  

<400>  71
cggagttaac cgaagagggg gtcgaggaga gccggagtcg gggacccagg agtttcctgt     60

gtccagcgct gccggagccg cctgaggtgc catgtttcag aacagagtaa gacccctggt    120

aaagaagaac tgaagatatt atacagatac cagatatagc ctaattacaa agaaagcatt    180

aacctgcctc tgaggtgact aaaggggaat aatggtgatt ttgcgccggg ctcggccgcc    240

tgcttccgcc ccaaccagca atg aat ctt gac tcg ctc tcg ctg gcc ttg tct    293
                      Met Asn Leu Asp Ser Leu Ser Leu Ala Leu Ser       
                      1               5                   10            

caa atc agc tac ctg gtg gac aat tta acc aag aaa aat tac cga gcc      341
Gln Ile Ser Tyr Leu Val Asp Asn Leu Thr Lys Lys Asn Tyr Arg Ala         
            15                  20                  25                  

agc cag cag gaa ata cag cat att gtg aat cgg cac ggt cct gag gca      389
Ser Gln Gln Glu Ile Gln His Ile Val Asn Arg His Gly Pro Glu Ala         
        30                  35                  40                      

gac agg cat tta tta cgc tgc cta ttt tcg cat gtg gat ttc agt ggc      437
Asp Arg His Leu Leu Arg Cys Leu Phe Ser His Val Asp Phe Ser Gly         
    45                  50                  55                          

gat ggt aaa agc agt ggc aaa gat ttc cat cag act cag ttt ctg att      485
Asp Gly Lys Ser Ser Gly Lys Asp Phe His Gln Thr Gln Phe Leu Ile         
60                  65                  70                  75          

cag gag tgt gcg ttg ctg att aca aag cca aat ttt atc tcg acg ctg      533
Gln Glu Cys Ala Leu Leu Ile Thr Lys Pro Asn Phe Ile Ser Thr Leu         
                80                  85                  90              

tcc tat gcc att gat aat cca ttg cac tat cag aag agt tta aag cct      581
Ser Tyr Ala Ile Asp Asn Pro Leu His Tyr Gln Lys Ser Leu Lys Pro         
            95                  100                 105                 

gca ccc cac tta ttt gcc cag ctg agt aaa gtg ctc aaa tta agc aaa      629
Ala Pro His Leu Phe Ala Gln Leu Ser Lys Val Leu Lys Leu Ser Lys         
        110                 115                 120                     

gta caa gag gta att ttt ggc ctt gcc ctg ttg aat tct tcc agc tca      677
Val Gln Glu Val Ile Phe Gly Leu Ala Leu Leu Asn Ser Ser Ser Ser         
    125                 130                 135                         

gat ctt aga ggt ttc gct gcc cag ttt atc aaa cag aag ctt cca gat      725
Asp Leu Arg Gly Phe Ala Ala Gln Phe Ile Lys Gln Lys Leu Pro Asp         
140                 145                 150                 155         

ctt ctg cgt tct tac att gac gca gac gtc agt gga aat caa gaa ggt      773
Leu Leu Arg Ser Tyr Ile Asp Ala Asp Val Ser Gly Asn Gln Glu Gly         
                160                 165                 170             

ggc ttc caa gat ata gca ata gag gtc cta cac ctc ctc ctc tcc cat      821
Gly Phe Gln Asp Ile Ala Ile Glu Val Leu His Leu Leu Leu Ser His         
            175                 180                 185                 

ctc ctc ttt ggg cag aag gga gcc ttt gga gtt gga caa gaa cag ata      869
Leu Leu Phe Gly Gln Lys Gly Ala Phe Gly Val Gly Gln Glu Gln Ile         
        190                 195                 200                     

gac gct ttt ctt aag acg ctg cgc aga gat ttt ccc caa gaa cgc tgt      917
Asp Ala Phe Leu Lys Thr Leu Arg Arg Asp Phe Pro Gln Glu Arg Cys         
    205                 210                 215                         

ccc gtg gtg ctc gca cca ctt tta tac cct gaa aaa cgg gac att cta      965
Pro Val Val Leu Ala Pro Leu Leu Tyr Pro Glu Lys Arg Asp Ile Leu         
220                 225                 230                 235         

atg gac agg atc ctg cct gat tcc gga ggg gta tct aaa acc atg atg     1013
Met Asp Arg Ile Leu Pro Asp Ser Gly Gly Val Ser Lys Thr Met Met         
                240                 245                 250             

gag agc tct ttg gct gat ttc atg caa gaa gta ggc tat ggc ttt tgt     1061
Glu Ser Ser Leu Ala Asp Phe Met Gln Glu Val Gly Tyr Gly Phe Cys         
            255                 260                 265                 

gca agt att gaa gaa tgt cgc aat ata atc gtg cag ttt ggt gtt cgg     1109
Ala Ser Ile Glu Glu Cys Arg Asn Ile Ile Val Gln Phe Gly Val Arg         
        270                 275                 280                     

gag gtc aca gct gcc cag gtt gca agg gtt ttg gga atg atg gct cga     1157
Glu Val Thr Ala Ala Gln Val Ala Arg Val Leu Gly Met Met Ala Arg         
    285                 290                 295                         

act cat tca gga tta aca gat ggc att cca tta cag agt att tct gct     1205
Thr His Ser Gly Leu Thr Asp Gly Ile Pro Leu Gln Ser Ile Ser Ala         
300                 305                 310                 315         

ccg ggc agt ggg atc tgg agt gat ggg aaa gat aaa agt gat gga gca     1253
Pro Gly Ser Gly Ile Trp Ser Asp Gly Lys Asp Lys Ser Asp Gly Ala         
                320                 325                 330             

cag gca cac aca tgg aat gta gaa gtc ttg att gac gtt ctt aaa gaa     1301
Gln Ala His Thr Trp Asn Val Glu Val Leu Ile Asp Val Leu Lys Glu         
            335                 340                 345                 

ctg aat cca agt ttg aat ttc aag gaa gta act tat gaa ctg gac cat     1349
Leu Asn Pro Ser Leu Asn Phe Lys Glu Val Thr Tyr Glu Leu Asp His         
        350                 355                 360                     

cct gga ttt caa att cgt gac agt aaa gga ctt cat aat gtg gtt tat     1397
Pro Gly Phe Gln Ile Arg Asp Ser Lys Gly Leu His Asn Val Val Tyr         
    365                 370                 375                         

ggc att cag agg ggt ttg ggt atg gaa gtg ttc cca gta gac ctc ata     1445
Gly Ile Gln Arg Gly Leu Gly Met Glu Val Phe Pro Val Asp Leu Ile         
380                 385                 390                 395         

tat aga cct tgg aaa cat gct gaa ggc cag ctc tcc ttc att caa cat     1493
Tyr Arg Pro Trp Lys His Ala Glu Gly Gln Leu Ser Phe Ile Gln His         
                400                 405                 410             

tcc ctt ata aat cca gag atc ttc tgt ttt gct gac tat ccc tgt cat     1541
Ser Leu Ile Asn Pro Glu Ile Phe Cys Phe Ala Asp Tyr Pro Cys His         
            415                 420                 425                 

act gtt gcc act gat att ctg aaa gca cca cca gag gat gac aat cga     1589
Thr Val Ala Thr Asp Ile Leu Lys Ala Pro Pro Glu Asp Asp Asn Arg         
        430                 435                 440                     

gaa att gcc aca tgg aag agc ttg gat ttg att gaa tct ctg ctg agg     1637
Glu Ile Ala Thr Trp Lys Ser Leu Asp Leu Ile Glu Ser Leu Leu Arg         
    445                 450                 455                         

ctt gca gag gtt ggg cag tat gag caa gtc aaa cag ctc ttc agc ttc     1685
Leu Ala Glu Val Gly Gln Tyr Glu Gln Val Lys Gln Leu Phe Ser Phe         
460                 465                 470                 475         

cct atc aaa cac tgt cca gac atg ctg gta ttg gcc tta cta caa att     1733
Pro Ile Lys His Cys Pro Asp Met Leu Val Leu Ala Leu Leu Gln Ile         
                480                 485                 490             

aac acc tct tgg cat acc ttg cgc cat gaa ctt atc tcc act ctg atg     1781
Asn Thr Ser Trp His Thr Leu Arg His Glu Leu Ile Ser Thr Leu Met         
            495                 500                 505                 

cca att ttc ctt gga aac cat cct aac tca gct att att ttg cac tat     1829
Pro Ile Phe Leu Gly Asn His Pro Asn Ser Ala Ile Ile Leu His Tyr         
        510                 515                 520                     

gca tgg cat ggg cag gga cag tct ccc tca att cgc caa ctt atc atg     1877
Ala Trp His Gly Gln Gly Gln Ser Pro Ser Ile Arg Gln Leu Ile Met         
    525                 530                 535                         

cat gca atg gca gaa tgg tac atg aga ggg gag cag tat gat cag gcc     1925
His Ala Met Ala Glu Trp Tyr Met Arg Gly Glu Gln Tyr Asp Gln Ala         
540                 545                 550                 555         

aaa ttg tct cga ata ctt gat gtg gcc cag gac ttg aag gcc ttg tca     1973
Lys Leu Ser Arg Ile Leu Asp Val Ala Gln Asp Leu Lys Ala Leu Ser         
                560                 565                 570             

atg ctg cta aat ggt act cca ttt gcc ttt gtt att gac ctt gct gca     2021
Met Leu Leu Asn Gly Thr Pro Phe Ala Phe Val Ile Asp Leu Ala Ala         
            575                 580                 585                 

ctt gct tca cgt cgt gaa tac ctc aaa ctt gat aag tgg ctc aca gat     2069
Leu Ala Ser Arg Arg Glu Tyr Leu Lys Leu Asp Lys Trp Leu Thr Asp         
        590                 595                 600                     

aaa att cga gag cat ggg gag cct ttt atc cag gcg tgt atg act ttt     2117
Lys Ile Arg Glu His Gly Glu Pro Phe Ile Gln Ala Cys Met Thr Phe         
    605                 610                 615                         

tta aag aga cgg tgt cct tct att ttg ggc gga ctt gcc cca gaa aaa     2165
Leu Lys Arg Arg Cys Pro Ser Ile Leu Gly Gly Leu Ala Pro Glu Lys         
620                 625                 630                 635         

gac cag ccc aaa agt gct caa ctt cct cca gaa act ttg gcg aca atg     2213
Asp Gln Pro Lys Ser Ala Gln Leu Pro Pro Glu Thr Leu Ala Thr Met         
                640                 645                 650             

ttg gcc tgt ctg caa gct tgt gca ggg agt gtt tct cag gag cta tca     2261
Leu Ala Cys Leu Gln Ala Cys Ala Gly Ser Val Ser Gln Glu Leu Ser         
            655                 660                 665                 

gaa act atc ctc acc atg gta gcc aat tgc agt aat gtt atg aat aag     2309
Glu Thr Ile Leu Thr Met Val Ala Asn Cys Ser Asn Val Met Asn Lys         
        670                 675                 680                     

gcc aga caa cca cca cct gga gtt atg cca aaa gga cgt cct cct agt     2357
Ala Arg Gln Pro Pro Pro Gly Val Met Pro Lys Gly Arg Pro Pro Ser         
    685                 690                 695                         

gct agc agc tta gat gcc att tct cct gtt cag att gac cct ctt gct     2405
Ala Ser Ser Leu Asp Ala Ile Ser Pro Val Gln Ile Asp Pro Leu Ala         
700                 705                 710                 715         

gga atg aca tct ctt agt ata ggt ggt tca gct gcc cct cac acc cag     2453
Gly Met Thr Ser Leu Ser Ile Gly Gly Ser Ala Ala Pro His Thr Gln         
                720                 725                 730             

agt atg cag ggt ttt cct cca aat ttg ggt tct gca ttc agt acc cct     2501
Ser Met Gln Gly Phe Pro Pro Asn Leu Gly Ser Ala Phe Ser Thr Pro         
            735                 740                 745                 

cag tca cca gca aaa gca ttt cca ccc ctt tca acc ccc aat cag acc     2549
Gln Ser Pro Ala Lys Ala Phe Pro Pro Leu Ser Thr Pro Asn Gln Thr         
        750                 755                 760                     

act gca ttc agt ggt att gga gga ctt tca tca cag ctt cca gta ggt     2597
Thr Ala Phe Ser Gly Ile Gly Gly Leu Ser Ser Gln Leu Pro Val Gly         
    765                 770                 775                         

ggt ctt ggc aca ggc agc ctg act ggt ata gga act ggt gct ctt gga     2645
Gly Leu Gly Thr Gly Ser Leu Thr Gly Ile Gly Thr Gly Ala Leu Gly         
780                 785                 790                 795         

ctc cct gca gtg aat aac gac cct ttt gta cag agg aaa ctg ggc acc     2693
Leu Pro Ala Val Asn Asn Asp Pro Phe Val Gln Arg Lys Leu Gly Thr         
                800                 805                 810             

tct gga ctg aat cag cct aca ttc cag cag agt aag atg aaa cct tcg     2741
Ser Gly Leu Asn Gln Pro Thr Phe Gln Gln Ser Lys Met Lys Pro Ser         
            815                 820                 825                 

gac ttg tct cag gtg tgg cca gag gca aac cag cac ttt agt aaa gag     2789
Asp Leu Ser Gln Val Trp Pro Glu Ala Asn Gln His Phe Ser Lys Glu         
        830                 835                 840                     

ata gat gat gaa gca aac agc tat ttc cag cga ata tat aat cat cca     2837
Ile Asp Asp Glu Ala Asn Ser Tyr Phe Gln Arg Ile Tyr Asn His Pro         
    845                 850                 855                         

cca cat cca acc atg tct gtt gat gag gta tta gaa atg ctg cag aga     2885
Pro His Pro Thr Met Ser Val Asp Glu Val Leu Glu Met Leu Gln Arg         
860                 865                 870                 875         

ttt aaa gac tct act ata aag agg gaa cga gaa gta ttt aac tgt atg     2933
Phe Lys Asp Ser Thr Ile Lys Arg Glu Arg Glu Val Phe Asn Cys Met         
                880                 885                 890             

cta agg aac ttg ttt gaa gaa tat cgt ttt ttt ccc cag tat cct gat     2981
Leu Arg Asn Leu Phe Glu Glu Tyr Arg Phe Phe Pro Gln Tyr Pro Asp         
            895                 900                 905                 

aaa gag tta cat ata aca gcc tgc cta ttt ggt ggt ata att gag aaa     3029
Lys Glu Leu His Ile Thr Ala Cys Leu Phe Gly Gly Ile Ile Glu Lys         
        910                 915                 920                     

gga ctg gtc act tac atg gca cta ggt ctg gct cta cga tat gtt ctt     3077
Gly Leu Val Thr Tyr Met Ala Leu Gly Leu Ala Leu Arg Tyr Val Leu         
    925                 930                 935                         

gaa gcc tta cgc aag cct ttt gga tcc aaa atg tat tat ttc ggg att     3125
Glu Ala Leu Arg Lys Pro Phe Gly Ser Lys Met Tyr Tyr Phe Gly Ile         
940                 945                 950                 955         

gct gca cta gat aga ttt aaa aac aga ttg aag gac tat ccc cag tat     3173
Ala Ala Leu Asp Arg Phe Lys Asn Arg Leu Lys Asp Tyr Pro Gln Tyr         
                960                 965                 970             

tgt cag cat ttg gct tct atc agt cac ttt atg caa ttt cca cat cat     3221
Cys Gln His Leu Ala Ser Ile Ser His Phe Met Gln Phe Pro His His         
            975                 980                 985                 

tta cag gag tat att gag tat gga cag cag tct aga gat  cct cct gtg    3269
Leu Gln Glu Tyr Ile Glu Tyr Gly Gln Gln Ser Arg Asp  Pro Pro Val        
        990                 995                 1000                    

aaa atg  caa ggc tct atc aca  acc cct gga agt att  gca ctg gct      3314
Lys Met  Gln Gly Ser Ile Thr  Thr Pro Gly Ser Ile  Ala Leu Ala          
    1005                 1010                 1015                      

cag gcc  cag gct cag gcc cag  gtt cca gca aaa gct  cct ctt gct      3359
Gln Ala  Gln Ala Gln Ala Gln  Val Pro Ala Lys Ala  Pro Leu Ala          
    1020                 1025                 1030                      

ggt caa  gtt agc act atg gta  acc acc tca aca act  acc act gtt      3404
Gly Gln  Val Ser Thr Met Val  Thr Thr Ser Thr Thr  Thr Thr Val          
    1035                 1040                 1045                      

gct aaa  acg gtt acg gtc acc  agg cca act gga gtc  agc ttt aag      3449
Ala Lys  Thr Val Thr Val Thr  Arg Pro Thr Gly Val  Ser Phe Lys          
    1050                 1055                 1060                      

aaa gat  gtg cca cct tct att  aat act aca aat ata  gat acg ttg      3494
Lys Asp  Val Pro Pro Ser Ile  Asn Thr Thr Asn Ile  Asp Thr Leu          
    1065                 1070                 1075                      

ctt gtg  gcc aca gat caa act  gag aga att gtg gag  ccc cca gaa      3539
Leu Val  Ala Thr Asp Gln Thr  Glu Arg Ile Val Glu  Pro Pro Glu          
    1080                 1085                 1090                      

aat atc  cag gag aaa att gct  ttt att ttc aat aat  ctc tca cag      3584
Asn Ile  Gln Glu Lys Ile Ala  Phe Ile Phe Asn Asn  Leu Ser Gln          
    1095                 1100                 1105                      

tca aat  atg aca caa aag gtt  gaa gag cta aag gaa  acg gtg aaa      3629
Ser Asn  Met Thr Gln Lys Val  Glu Glu Leu Lys Glu  Thr Val Lys          
    1110                 1115                 1120                      

gaa gaa  ttt atg cct tgg gtt  tca cag tat ctg gtt  atg aag aga      3674
Glu Glu  Phe Met Pro Trp Val  Ser Gln Tyr Leu Val  Met Lys Arg          
    1125                 1130                 1135                      

gtc agt  att gag cca aac ttt  cat agc ctg tat tca  aac ttc ctt      3719
Val Ser  Ile Glu Pro Asn Phe  His Ser Leu Tyr Ser  Asn Phe Leu          
    1140                 1145                 1150                      

gac acg  ctg aag aat cct gaa  ttt aac aag atg gtt  ctg aat gag      3764
Asp Thr  Leu Lys Asn Pro Glu  Phe Asn Lys Met Val  Leu Asn Glu          
    1155                 1160                 1165                      

acc tac  aga aac att aaa gtg  ctc ctg acc tct gat  aaa gct gca      3809
Thr Tyr  Arg Asn Ile Lys Val  Leu Leu Thr Ser Asp  Lys Ala Ala          
    1170                 1175                 1180                      

gcc aat  ttc tca gat cgt tct  ttg ctg aag aac ttg  gga cat tgg      3854
Ala Asn  Phe Ser Asp Arg Ser  Leu Leu Lys Asn Leu  Gly His Trp          
    1185                 1190                 1195                      

cta gga  atg atc aca tta gct  aaa aac aaa ccc atc  tta cac act      3899
Leu Gly  Met Ile Thr Leu Ala  Lys Asn Lys Pro Ile  Leu His Thr          
    1200                 1205                 1210                      

gac ttg  gat gtg aaa tca ttg  ctg cta gag gct tat  gtt aaa gga      3944
Asp Leu  Asp Val Lys Ser Leu  Leu Leu Glu Ala Tyr  Val Lys Gly          
    1215                 1220                 1225                      

caa caa  gaa ttg ctc tat gta  gtg ccc ttt gtt gcc  aaa gtc tta      3989
Gln Gln  Glu Leu Leu Tyr Val  Val Pro Phe Val Ala  Lys Val Leu          
    1230                 1235                 1240                      

gaa tct  agc att cgt agt gtg  gtt ttt agg cca cca  aac cct tgg      4034
Glu Ser  Ser Ile Arg Ser Val  Val Phe Arg Pro Pro  Asn Pro Trp          
    1245                 1250                 1255                      

aca atg  gca att atg aat gta  tta gct gag cta cat  cag gag cat      4079
Thr Met  Ala Ile Met Asn Val  Leu Ala Glu Leu His  Gln Glu His          
    1260                 1265                 1270                      

gac tta  aag tta aac ttg aag  ttt gaa atc gag gtt  ctc tgc aag      4124
Asp Leu  Lys Leu Asn Leu Lys  Phe Glu Ile Glu Val  Leu Cys Lys          
    1275                 1280                 1285                      

aac ctt  gca tta gac atc aat  gag cta aaa cct gga  aac ctc cta      4169
Asn Leu  Ala Leu Asp Ile Asn  Glu Leu Lys Pro Gly  Asn Leu Leu          
    1290                 1295                 1300                      

aag gat  aaa gat cgc ctg aag  aat tta gat gag caa  ctc tct gct      4214
Lys Asp  Lys Asp Arg Leu Lys  Asn Leu Asp Glu Gln  Leu Ser Ala          
    1305                 1310                 1315                      

cca aag  aaa gat gtc aag cag  cca gaa gaa ctc cct  ccc atc aca      4259
Pro Lys  Lys Asp Val Lys Gln  Pro Glu Glu Leu Pro  Pro Ile Thr          
    1320                 1325                 1330                      

acc aca  aca act tct act aca  cca gct acc aac acc  act tgt aca      4304
Thr Thr  Thr Thr Ser Thr Thr  Pro Ala Thr Asn Thr  Thr Cys Thr          
    1335                 1340                 1345                      

gcc acg  gtt cca cca cag cca  cag tac agc tac cac  gac atc aat      4349
Ala Thr  Val Pro Pro Gln Pro  Gln Tyr Ser Tyr His  Asp Ile Asn          
    1350                 1355                 1360                      

gtc tat  tcc ctt gcg ggc ttg  gca cca cac att act  cta aat cca      4394
Val Tyr  Ser Leu Ala Gly Leu  Ala Pro His Ile Thr  Leu Asn Pro          
    1365                 1370                 1375                      

aca att  ccc ttg ttt cag gcc  cat cca cag ttg aag  cag tgt gtg      4439
Thr Ile  Pro Leu Phe Gln Ala  His Pro Gln Leu Lys  Gln Cys Val          
    1380                 1385                 1390                      

cgt cag  gca att gaa cgg gct  gtc cag gag ctg gtc  cat cct gtg      4484
Arg Gln  Ala Ile Glu Arg Ala  Val Gln Glu Leu Val  His Pro Val          
    1395                 1400                 1405                      

gtg gat  cga tca att aag att  gcc atg act act tgt  gag caa ata      4529
Val Asp  Arg Ser Ile Lys Ile  Ala Met Thr Thr Cys  Glu Gln Ile          
    1410                 1415                 1420                      

gtc agg  aag gat ttt gcc ctg  gat tcg gag gaa tct  cga atg cga      4574
Val Arg  Lys Asp Phe Ala Leu  Asp Ser Glu Glu Ser  Arg Met Arg          
    1425                 1430                 1435                      

ata gca  gct cat cac atg atg  cgt aac ttg aca gct  gga atg gct      4619
Ile Ala  Ala His His Met Met  Arg Asn Leu Thr Ala  Gly Met Ala          
    1440                 1445                 1450                      

atg att  aca tgc agg gaa cct  ttg ctc atg agc ata  tct acc aac      4664
Met Ile  Thr Cys Arg Glu Pro  Leu Leu Met Ser Ile  Ser Thr Asn          
    1455                 1460                 1465                      

tta aaa  aac agt ttt gcc tca  gcc ctt cgt act gct  tcc cca caa      4709
Leu Lys  Asn Ser Phe Ala Ser  Ala Leu Arg Thr Ala  Ser Pro Gln          
    1470                 1475                 1480                      

caa aga  gaa atg atg gat cag  gca gct gct caa tta  gct cag gac      4754
Gln Arg  Glu Met Met Asp Gln  Ala Ala Ala Gln Leu  Ala Gln Asp          
    1485                 1490                 1495                      

aat tgt  gag ttg gct tgc tgt  ttt att cag aag act  gca gta gaa      4799
Asn Cys  Glu Leu Ala Cys Cys  Phe Ile Gln Lys Thr  Ala Val Glu          
    1500                 1505                 1510                      

aaa gca  ggc cct gag atg gac  aag aga tta gca act  gaa ttt gag      4844
Lys Ala  Gly Pro Glu Met Asp  Lys Arg Leu Ala Thr  Glu Phe Glu          
    1515                 1520                 1525                      

ctg aga  aaa cat gct agg caa  gaa gga cgc aga tac  tgt gat cct      4889
Leu Arg  Lys His Ala Arg Gln  Glu Gly Arg Arg Tyr  Cys Asp Pro          
    1530                 1535                 1540                      

gtt gtt  tta aca tat caa gct  gaa cgg atg cca gag  caa atc agg      4934
Val Val  Leu Thr Tyr Gln Ala  Glu Arg Met Pro Glu  Gln Ile Arg          
    1545                 1550                 1555                      

ctg aaa  gtt ggt ggt gtg gac  cca aag cag ttg gct  gtt tac gaa      4979
Leu Lys  Val Gly Gly Val Asp  Pro Lys Gln Leu Ala  Val Tyr Glu          
    1560                 1565                 1570                      

gag ttt  gca cgc aat gtt cct  ggc ttc tta cct aca  aat gac tta      5024
Glu Phe  Ala Arg Asn Val Pro  Gly Phe Leu Pro Thr  Asn Asp Leu          
    1575                 1580                 1585                      

agt cag  ccc acg gga ttt tta  gcc cag ccc atg aag  caa gct tgg      5069
Ser Gln  Pro Thr Gly Phe Leu  Ala Gln Pro Met Lys  Gln Ala Trp          
    1590                 1595                 1600                      

gca aca  gat gat gta gct cag  att tat gat aag tgt  att aca gaa      5114
Ala Thr  Asp Asp Val Ala Gln  Ile Tyr Asp Lys Cys  Ile Thr Glu          
    1605                 1610                 1615                      

ctg gag  caa cat cta cat gcc  atc cca cca act ttg  gcc atg aac      5159
Leu Glu  Gln His Leu His Ala  Ile Pro Pro Thr Leu  Ala Met Asn          
    1620                 1625                 1630                      

cct caa  gct cag gct ctt cga  agt ctc ttg gag gtt  gta gtt tta      5204
Pro Gln  Ala Gln Ala Leu Arg  Ser Leu Leu Glu Val  Val Val Leu          
    1635                 1640                 1645                      

tct cga  aac tct cgg gat gcc  ata gct gct ctt gga  ttg ctc caa      5249
Ser Arg  Asn Ser Arg Asp Ala  Ile Ala Ala Leu Gly  Leu Leu Gln          
    1650                 1655                 1660                      

aag gct  gta gag ggc tta cta  gat gcc aca agt ggt  gct gat gct      5294
Lys Ala  Val Glu Gly Leu Leu  Asp Ala Thr Ser Gly  Ala Asp Ala          
    1665                 1670                 1675                      

gac ctt  ctg ctg cgc tac agg  gaa tgc cac ctc ttg  gtc cta aaa      5339
Asp Leu  Leu Leu Arg Tyr Arg  Glu Cys His Leu Leu  Val Leu Lys          
    1680                 1685                 1690                      

gct ctg  cag gat ggc cgg gca  tat ggg tct cca tgg  tgc aac aaa      5384
Ala Leu  Gln Asp Gly Arg Ala  Tyr Gly Ser Pro Trp  Cys Asn Lys          
    1695                 1700                 1705                      

cag atc  aca agg tgc cta att  gaa tgt cga gat gaa  tat aaa tat      5429
Gln Ile  Thr Arg Cys Leu Ile  Glu Cys Arg Asp Glu  Tyr Lys Tyr          
    1710                 1715                 1720                      

aat gtg  gag gct gtg gag ctg  cta att cgc aat cat  ttg gtt aat      5474
Asn Val  Glu Ala Val Glu Leu  Leu Ile Arg Asn His  Leu Val Asn          
    1725                 1730                 1735                      

atg cag  cag tat gat ctt cac  cta gcg cag tca atg  gag aat ggc      5519
Met Gln  Gln Tyr Asp Leu His  Leu Ala Gln Ser Met  Glu Asn Gly          
    1740                 1745                 1750                      

tta aac  tac atg gct gtg gca  ttt gct atg cag tta  gta aaa atc      5564
Leu Asn  Tyr Met Ala Val Ala  Phe Ala Met Gln Leu  Val Lys Ile          
    1755                 1760                 1765                      

ctg ctg  gtg gat gaa agg agt  gtt gct cat gtt act  gag gca gat      5609
Leu Leu  Val Asp Glu Arg Ser  Val Ala His Val Thr  Glu Ala Asp          
    1770                 1775                 1780                      

ctg ttc  cac acc att gaa acc  ctc atg agg att aat  gct cat tcc      5654
Leu Phe  His Thr Ile Glu Thr  Leu Met Arg Ile Asn  Ala His Ser          
    1785                 1790                 1795                      

aga ggc  aat gct cca gaa gga  ttg ccc cag ctg atg  gaa gta gtg      5699
Arg Gly  Asn Ala Pro Glu Gly  Leu Pro Gln Leu Met  Glu Val Val          
    1800                 1805                 1810                      

cga tcc  aac tat gaa gca atg  att gat cgt gct cat  gga ggc cca      5744
Arg Ser  Asn Tyr Glu Ala Met  Ile Asp Arg Ala His  Gly Gly Pro          
    1815                 1820                 1825                      

aac ttt  atg atg cat tct ggg  atc tct caa gcc tca  gag tat gat      5789
Asn Phe  Met Met His Ser Gly  Ile Ser Gln Ala Ser  Glu Tyr Asp          
    1830                 1835                 1840                      

gac cct  cca ggc ctg agg gag  aag gca gag tat ctt  ctg agg gaa      5834
Asp Pro  Pro Gly Leu Arg Glu  Lys Ala Glu Tyr Leu  Leu Arg Glu          
    1845                 1850                 1855                      

tgg gtg  aat ctc tac cat tca  gca gca gct ggc cgc  gac agt acc      5879
Trp Val  Asn Leu Tyr His Ser  Ala Ala Ala Gly Arg  Asp Ser Thr          
    1860                 1865                 1870                      

aaa gct  ttc tct gca ttt gtt  gga cag atg cac cag  caa gga ata      5924
Lys Ala  Phe Ser Ala Phe Val  Gly Gln Met His Gln  Gln Gly Ile          
    1875                 1880                 1885                      

ctg aag  acc gat gat ctc ata  aca agg ttc ttt cgt  ctg tgt act      5969
Leu Lys  Thr Asp Asp Leu Ile  Thr Arg Phe Phe Arg  Leu Cys Thr          
    1890                 1895                 1900                      

gaa atg  tgt gtt gaa atc agt  tac cgt gct cag gct  gag cag cag      6014
Glu Met  Cys Val Glu Ile Ser  Tyr Arg Ala Gln Ala  Glu Gln Gln          
    1905                 1910                 1915                      

cac aat  cct gct gcc aat ccc  acc atg atc cga gcc  aag tgc tat      6059
His Asn  Pro Ala Ala Asn Pro  Thr Met Ile Arg Ala  Lys Cys Tyr          
    1920                 1925                 1930                      

cac aac  ctg gat gcc ttt gtt  cga ctc att gca ctg  ctc gtg aaa      6104
His Asn  Leu Asp Ala Phe Val  Arg Leu Ile Ala Leu  Leu Val Lys          
    1935                 1940                 1945                      

cac tca  ggg gag gcc acc aac  act gtc aca aag att  aat ctg ctg      6149
His Ser  Gly Glu Ala Thr Asn  Thr Val Thr Lys Ile  Asn Leu Leu          
    1950                 1955                 1960                      

aac aag  gtc ctt ggt ata gta  gtg gga gtt ctc ctt  cag gat cat      6194
Asn Lys  Val Leu Gly Ile Val  Val Gly Val Leu Leu  Gln Asp His          
    1965                 1970                 1975                      

gat gtt  cgt cag agt gaa ttt  cag caa ctt ccc tac  cat cga att      6239
Asp Val  Arg Gln Ser Glu Phe  Gln Gln Leu Pro Tyr  His Arg Ile          
    1980                 1985                 1990                      

ttt atc  atg ctt ctc ttg gaa  ctc aat gca cct gag  cat gtg ttg      6284
Phe Ile  Met Leu Leu Leu Glu  Leu Asn Ala Pro Glu  His Val Leu          
    1995                 2000                 2005                      

gaa acc  att aat ttc cag aca  ctt aca gct ttc tgc  aat aca ttc      6329
Glu Thr  Ile Asn Phe Gln Thr  Leu Thr Ala Phe Cys  Asn Thr Phe          
    2010                 2015                 2020                      

cac atc  ttg agg cct acc aaa  gct cct ggc ttt gta  tat gcc tgg      6374
His Ile  Leu Arg Pro Thr Lys  Ala Pro Gly Phe Val  Tyr Ala Trp          
    2025                 2030                 2035                      

ctt gaa  ctg att tcc cat cgg  ata ttt att gca aga  atg ctg gca      6419
Leu Glu  Leu Ile Ser His Arg  Ile Phe Ile Ala Arg  Met Leu Ala          
    2040                 2045                 2050                      

cat acg  cca cag cag aag ggg  tgg cct atg tat gca  cag cta ctg      6464
His Thr  Pro Gln Gln Lys Gly  Trp Pro Met Tyr Ala  Gln Leu Leu          
    2055                 2060                 2065                      

att gat  tta ttc aaa tat tta  gcg cct ttc ctt aga  aat gtg gaa      6509
Ile Asp  Leu Phe Lys Tyr Leu  Ala Pro Phe Leu Arg  Asn Val Glu          
    2070                 2075                 2080                      

ctc acc  aaa cct atg caa atc  ctc tac aag ggc act  tta aga gtg      6554
Leu Thr  Lys Pro Met Gln Ile  Leu Tyr Lys Gly Thr  Leu Arg Val          
    2085                 2090                 2095                      

ctg ctg  gtt ctt ttg cat gat  ttc cca gag ttc ctt  tgt gat tac      6599
Leu Leu  Val Leu Leu His Asp  Phe Pro Glu Phe Leu  Cys Asp Tyr          
    2100                 2105                 2110                      

cat tat  ggg ttc tgt gat gtg  atc cca cct aat tgt  atc cag tta      6644
His Tyr  Gly Phe Cys Asp Val  Ile Pro Pro Asn Cys  Ile Gln Leu          
    2115                 2120                 2125                      

aga aat  ttg atc ctg agt gcc  ttt cca aga aac atg  agg ctc ccc      6689
Arg Asn  Leu Ile Leu Ser Ala  Phe Pro Arg Asn Met  Arg Leu Pro          
    2130                 2135                 2140                      

gac cca  ttc act cct aat cta  aag gtg gac atg ttg  agt gaa att      6734
Asp Pro  Phe Thr Pro Asn Leu  Lys Val Asp Met Leu  Ser Glu Ile          
    2145                 2150                 2155                      

aac att  gct ccc cgg att ctc  acc aat ttc act gga  gta atg cca      6779
Asn Ile  Ala Pro Arg Ile Leu  Thr Asn Phe Thr Gly  Val Met Pro          
    2160                 2165                 2170                      

cct cag  ttc aaa aag gat ttg  gat tcc tat ctt aaa  act cga tca      6824
Pro Gln  Phe Lys Lys Asp Leu  Asp Ser Tyr Leu Lys  Thr Arg Ser          
    2175                 2180                 2185                      

cca gtc  act ttc ctg tct gat  ctg cgc agc aac cta  cag gta tcc      6869
Pro Val  Thr Phe Leu Ser Asp  Leu Arg Ser Asn Leu  Gln Val Ser          
    2190                 2195                 2200                      

aat gaa  cct ggg aat cgc tac  aac ctc cag ctc atc  aat gca ctg      6914
Asn Glu  Pro Gly Asn Arg Tyr  Asn Leu Gln Leu Ile  Asn Ala Leu          
    2205                 2210                 2215                      

gtg ctc  tat gtc ggg act cag  gcc att gcg cac atc  cac aac aag      6959
Val Leu  Tyr Val Gly Thr Gln  Ala Ile Ala His Ile  His Asn Lys          
    2220                 2225                 2230                      

ggc agc  aca cct tca atg agc  acc atc act cac tca  gca cac atg      7004
Gly Ser  Thr Pro Ser Met Ser  Thr Ile Thr His Ser  Ala His Met          
    2235                 2240                 2245                      

gat atc  ttc cag aat ttg gct  gtg gac ttg gac act  gag ggt cgc      7049
Asp Ile  Phe Gln Asn Leu Ala  Val Asp Leu Asp Thr  Glu Gly Arg          
    2250                 2255                 2260                      

tat ctc  ttt ttg aat gca att  gca aat cag ctc cgg  tac cca aat      7094
Tyr Leu  Phe Leu Asn Ala Ile  Ala Asn Gln Leu Arg  Tyr Pro Asn          
    2265                 2270                 2275                      

agc cac  act cac tac ttc agt  tgc acc atg ctg tac  ctt ttt gca      7139
Ser His  Thr His Tyr Phe Ser  Cys Thr Met Leu Tyr  Leu Phe Ala          
    2280                 2285                 2290                      

gag gcc  aat acg gaa gcc atc  caa gaa cag atc aca  aga gtt ctc      7184
Glu Ala  Asn Thr Glu Ala Ile  Gln Glu Gln Ile Thr  Arg Val Leu          
    2295                 2300                 2305                      

ttg gaa  cgg ttg att gta aat  agg cca cat cct tgg  ggt ctt ctt      7229
Leu Glu  Arg Leu Ile Val Asn  Arg Pro His Pro Trp  Gly Leu Leu          
    2310                 2315                 2320                      

att acc  ttc att gag ctg att  aaa aac cca gcg ttt  aag ttc tgg      7274
Ile Thr  Phe Ile Glu Leu Ile  Lys Asn Pro Ala Phe  Lys Phe Trp          
    2325                 2330                 2335                      

aac cat  gaa ttt gta cac tgt  gcc cca gaa atc gaa  aag tta ttc      7319
Asn His  Glu Phe Val His Cys  Ala Pro Glu Ile Glu  Lys Leu Phe          
    2340                 2345                 2350                      

cag tcg  gtc gca cag tgc tgc  atg gga cag aag cag  gcc cag caa      7364
Gln Ser  Val Ala Gln Cys Cys  Met Gly Gln Lys Gln  Ala Gln Gln          
    2355                 2360                 2365                      

gta atg  gaa ggg aca ggt gcc  agt tag acgaaactgc atctctgttg         7411
Val Met  Glu Gly Thr Gly Ala  Ser                                       
    2370                 2375                                           

tacgtgtcag tctagaggtc tcactgcacc gagttcataa actgactgaa gaatcctttc   7471

agctcttcct gactttccca gccctttggt ttgtgggtat ctgccccaac tactgttggg   7531

atcagcctcc tgtcttatgt gggcacgttc caaagtttaa atgcattttt ttgactcttg   7591

gccaaaattt agaagatgct gtgaatatca ttttgaactt gtgtaaatac atgaaagaga   7651

aaacctttgt ctggaacttc ttggctttgt gcaagctgtg tccaaggcaa gtacataaac   7711

tggtaccttg taatgaagag gcagctgatg ccatgcactt gtctgagggc atagctccat   7771

gtcttctgac attcctggtg tcccaaagaa tagcaaaaag ccagtttgaa tattatgtaa   7831

cttatttttt taatgtggac aggggacctt gaaaatcact aagttattaa aaatgtggga   7891

tgtgctagaa ttggatatgt ccaggaacat gggaagggct cactattgga atcccatgag   7951

tttccatttt gtctctaccc aaacgtattc caaagctgac tgcatttgta ccatcttatt   8011

tcttttgggg attatacacc tcagccgcct gagatggggg tcagctcttt atataaaggg   8071

aaaccagacc aggcctaaag cccaccccct accctcaccc ccacaatcct ctcctgaaac   8131

ttaaaaacag tgggaatata ggaaagggaa ccaaatctca ttaattaatt gttctccccc   8191

attaccccac tgaatgaatg gccatacagg ctaagctgaa taatgacaaa gttgaaagga   8251

ccaatacagc cccttttata aggattttga atgttttgca aatgtattgg tccctgtgtt   8311

gtattttgta gccttttcct gggcttcagc tcccctactt cttgtatgtg tatgcatact   8371

gtagctaacc attaaagtca tgacacacaa aaaaaaaaaa aaaaaaaaaa aaaaa        8426


<210>  72
<211>  2376
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Asn Leu Asp Ser Leu Ser Leu Ala Leu Ser Gln Ile Ser Tyr Leu 
1               5                   10                  15      


Val Asp Asn Leu Thr Lys Lys Asn Tyr Arg Ala Ser Gln Gln Glu Ile 
            20                  25                  30          


Gln His Ile Val Asn Arg His Gly Pro Glu Ala Asp Arg His Leu Leu 
        35                  40                  45              


Arg Cys Leu Phe Ser His Val Asp Phe Ser Gly Asp Gly Lys Ser Ser 
    50                  55                  60                  


Gly Lys Asp Phe His Gln Thr Gln Phe Leu Ile Gln Glu Cys Ala Leu 
65                  70                  75                  80  


Leu Ile Thr Lys Pro Asn Phe Ile Ser Thr Leu Ser Tyr Ala Ile Asp 
                85                  90                  95      


Asn Pro Leu His Tyr Gln Lys Ser Leu Lys Pro Ala Pro His Leu Phe 
            100                 105                 110         


Ala Gln Leu Ser Lys Val Leu Lys Leu Ser Lys Val Gln Glu Val Ile 
        115                 120                 125             


Phe Gly Leu Ala Leu Leu Asn Ser Ser Ser Ser Asp Leu Arg Gly Phe 
    130                 135                 140                 


Ala Ala Gln Phe Ile Lys Gln Lys Leu Pro Asp Leu Leu Arg Ser Tyr 
145                 150                 155                 160 


Ile Asp Ala Asp Val Ser Gly Asn Gln Glu Gly Gly Phe Gln Asp Ile 
                165                 170                 175     


Ala Ile Glu Val Leu His Leu Leu Leu Ser His Leu Leu Phe Gly Gln 
            180                 185                 190         


Lys Gly Ala Phe Gly Val Gly Gln Glu Gln Ile Asp Ala Phe Leu Lys 
        195                 200                 205             


Thr Leu Arg Arg Asp Phe Pro Gln Glu Arg Cys Pro Val Val Leu Ala 
    210                 215                 220                 


Pro Leu Leu Tyr Pro Glu Lys Arg Asp Ile Leu Met Asp Arg Ile Leu 
225                 230                 235                 240 


Pro Asp Ser Gly Gly Val Ser Lys Thr Met Met Glu Ser Ser Leu Ala 
                245                 250                 255     


Asp Phe Met Gln Glu Val Gly Tyr Gly Phe Cys Ala Ser Ile Glu Glu 
            260                 265                 270         


Cys Arg Asn Ile Ile Val Gln Phe Gly Val Arg Glu Val Thr Ala Ala 
        275                 280                 285             


Gln Val Ala Arg Val Leu Gly Met Met Ala Arg Thr His Ser Gly Leu 
    290                 295                 300                 


Thr Asp Gly Ile Pro Leu Gln Ser Ile Ser Ala Pro Gly Ser Gly Ile 
305                 310                 315                 320 


Trp Ser Asp Gly Lys Asp Lys Ser Asp Gly Ala Gln Ala His Thr Trp 
                325                 330                 335     


Asn Val Glu Val Leu Ile Asp Val Leu Lys Glu Leu Asn Pro Ser Leu 
            340                 345                 350         


Asn Phe Lys Glu Val Thr Tyr Glu Leu Asp His Pro Gly Phe Gln Ile 
        355                 360                 365             


Arg Asp Ser Lys Gly Leu His Asn Val Val Tyr Gly Ile Gln Arg Gly 
    370                 375                 380                 


Leu Gly Met Glu Val Phe Pro Val Asp Leu Ile Tyr Arg Pro Trp Lys 
385                 390                 395                 400 


His Ala Glu Gly Gln Leu Ser Phe Ile Gln His Ser Leu Ile Asn Pro 
                405                 410                 415     


Glu Ile Phe Cys Phe Ala Asp Tyr Pro Cys His Thr Val Ala Thr Asp 
            420                 425                 430         


Ile Leu Lys Ala Pro Pro Glu Asp Asp Asn Arg Glu Ile Ala Thr Trp 
        435                 440                 445             


Lys Ser Leu Asp Leu Ile Glu Ser Leu Leu Arg Leu Ala Glu Val Gly 
    450                 455                 460                 


Gln Tyr Glu Gln Val Lys Gln Leu Phe Ser Phe Pro Ile Lys His Cys 
465                 470                 475                 480 


Pro Asp Met Leu Val Leu Ala Leu Leu Gln Ile Asn Thr Ser Trp His 
                485                 490                 495     


Thr Leu Arg His Glu Leu Ile Ser Thr Leu Met Pro Ile Phe Leu Gly 
            500                 505                 510         


Asn His Pro Asn Ser Ala Ile Ile Leu His Tyr Ala Trp His Gly Gln 
        515                 520                 525             


Gly Gln Ser Pro Ser Ile Arg Gln Leu Ile Met His Ala Met Ala Glu 
    530                 535                 540                 


Trp Tyr Met Arg Gly Glu Gln Tyr Asp Gln Ala Lys Leu Ser Arg Ile 
545                 550                 555                 560 


Leu Asp Val Ala Gln Asp Leu Lys Ala Leu Ser Met Leu Leu Asn Gly 
                565                 570                 575     


Thr Pro Phe Ala Phe Val Ile Asp Leu Ala Ala Leu Ala Ser Arg Arg 
            580                 585                 590         


Glu Tyr Leu Lys Leu Asp Lys Trp Leu Thr Asp Lys Ile Arg Glu His 
        595                 600                 605             


Gly Glu Pro Phe Ile Gln Ala Cys Met Thr Phe Leu Lys Arg Arg Cys 
    610                 615                 620                 


Pro Ser Ile Leu Gly Gly Leu Ala Pro Glu Lys Asp Gln Pro Lys Ser 
625                 630                 635                 640 


Ala Gln Leu Pro Pro Glu Thr Leu Ala Thr Met Leu Ala Cys Leu Gln 
                645                 650                 655     


Ala Cys Ala Gly Ser Val Ser Gln Glu Leu Ser Glu Thr Ile Leu Thr 
            660                 665                 670         


Met Val Ala Asn Cys Ser Asn Val Met Asn Lys Ala Arg Gln Pro Pro 
        675                 680                 685             


Pro Gly Val Met Pro Lys Gly Arg Pro Pro Ser Ala Ser Ser Leu Asp 
    690                 695                 700                 


Ala Ile Ser Pro Val Gln Ile Asp Pro Leu Ala Gly Met Thr Ser Leu 
705                 710                 715                 720 


Ser Ile Gly Gly Ser Ala Ala Pro His Thr Gln Ser Met Gln Gly Phe 
                725                 730                 735     


Pro Pro Asn Leu Gly Ser Ala Phe Ser Thr Pro Gln Ser Pro Ala Lys 
            740                 745                 750         


Ala Phe Pro Pro Leu Ser Thr Pro Asn Gln Thr Thr Ala Phe Ser Gly 
        755                 760                 765             


Ile Gly Gly Leu Ser Ser Gln Leu Pro Val Gly Gly Leu Gly Thr Gly 
    770                 775                 780                 


Ser Leu Thr Gly Ile Gly Thr Gly Ala Leu Gly Leu Pro Ala Val Asn 
785                 790                 795                 800 


Asn Asp Pro Phe Val Gln Arg Lys Leu Gly Thr Ser Gly Leu Asn Gln 
                805                 810                 815     


Pro Thr Phe Gln Gln Ser Lys Met Lys Pro Ser Asp Leu Ser Gln Val 
            820                 825                 830         


Trp Pro Glu Ala Asn Gln His Phe Ser Lys Glu Ile Asp Asp Glu Ala 
        835                 840                 845             


Asn Ser Tyr Phe Gln Arg Ile Tyr Asn His Pro Pro His Pro Thr Met 
    850                 855                 860                 


Ser Val Asp Glu Val Leu Glu Met Leu Gln Arg Phe Lys Asp Ser Thr 
865                 870                 875                 880 


Ile Lys Arg Glu Arg Glu Val Phe Asn Cys Met Leu Arg Asn Leu Phe 
                885                 890                 895     


Glu Glu Tyr Arg Phe Phe Pro Gln Tyr Pro Asp Lys Glu Leu His Ile 
            900                 905                 910         


Thr Ala Cys Leu Phe Gly Gly Ile Ile Glu Lys Gly Leu Val Thr Tyr 
        915                 920                 925             


Met Ala Leu Gly Leu Ala Leu Arg Tyr Val Leu Glu Ala Leu Arg Lys 
    930                 935                 940                 


Pro Phe Gly Ser Lys Met Tyr Tyr Phe Gly Ile Ala Ala Leu Asp Arg 
945                 950                 955                 960 


Phe Lys Asn Arg Leu Lys Asp Tyr Pro Gln Tyr Cys Gln His Leu Ala 
                965                 970                 975     


Ser Ile Ser His Phe Met Gln Phe Pro His His Leu Gln Glu Tyr Ile 
            980                 985                 990         


Glu Tyr Gly Gln Gln Ser Arg Asp  Pro Pro Val Lys Met  Gln Gly Ser 
        995                 1000                 1005             


Ile Thr  Thr Pro Gly Ser Ile  Ala Leu Ala Gln Ala  Gln Ala Gln 
    1010                 1015                 1020             


Ala Gln  Val Pro Ala Lys Ala  Pro Leu Ala Gly Gln  Val Ser Thr 
    1025                 1030                 1035             


Met Val  Thr Thr Ser Thr Thr  Thr Thr Val Ala Lys  Thr Val Thr 
    1040                 1045                 1050             


Val Thr  Arg Pro Thr Gly Val  Ser Phe Lys Lys Asp  Val Pro Pro 
    1055                 1060                 1065             


Ser Ile  Asn Thr Thr Asn Ile  Asp Thr Leu Leu Val  Ala Thr Asp 
    1070                 1075                 1080             


Gln Thr  Glu Arg Ile Val Glu  Pro Pro Glu Asn Ile  Gln Glu Lys 
    1085                 1090                 1095             


Ile Ala  Phe Ile Phe Asn Asn  Leu Ser Gln Ser Asn  Met Thr Gln 
    1100                 1105                 1110             


Lys Val  Glu Glu Leu Lys Glu  Thr Val Lys Glu Glu  Phe Met Pro 
    1115                 1120                 1125             


Trp Val  Ser Gln Tyr Leu Val  Met Lys Arg Val Ser  Ile Glu Pro 
    1130                 1135                 1140             


Asn Phe  His Ser Leu Tyr Ser  Asn Phe Leu Asp Thr  Leu Lys Asn 
    1145                 1150                 1155             


Pro Glu  Phe Asn Lys Met Val  Leu Asn Glu Thr Tyr  Arg Asn Ile 
    1160                 1165                 1170             


Lys Val  Leu Leu Thr Ser Asp  Lys Ala Ala Ala Asn  Phe Ser Asp 
    1175                 1180                 1185             


Arg Ser  Leu Leu Lys Asn Leu  Gly His Trp Leu Gly  Met Ile Thr 
    1190                 1195                 1200             


Leu Ala  Lys Asn Lys Pro Ile  Leu His Thr Asp Leu  Asp Val Lys 
    1205                 1210                 1215             


Ser Leu  Leu Leu Glu Ala Tyr  Val Lys Gly Gln Gln  Glu Leu Leu 
    1220                 1225                 1230             


Tyr Val  Val Pro Phe Val Ala  Lys Val Leu Glu Ser  Ser Ile Arg 
    1235                 1240                 1245             


Ser Val  Val Phe Arg Pro Pro  Asn Pro Trp Thr Met  Ala Ile Met 
    1250                 1255                 1260             


Asn Val  Leu Ala Glu Leu His  Gln Glu His Asp Leu  Lys Leu Asn 
    1265                 1270                 1275             


Leu Lys  Phe Glu Ile Glu Val  Leu Cys Lys Asn Leu  Ala Leu Asp 
    1280                 1285                 1290             


Ile Asn  Glu Leu Lys Pro Gly  Asn Leu Leu Lys Asp  Lys Asp Arg 
    1295                 1300                 1305             


Leu Lys  Asn Leu Asp Glu Gln  Leu Ser Ala Pro Lys  Lys Asp Val 
    1310                 1315                 1320             


Lys Gln  Pro Glu Glu Leu Pro  Pro Ile Thr Thr Thr  Thr Thr Ser 
    1325                 1330                 1335             


Thr Thr  Pro Ala Thr Asn Thr  Thr Cys Thr Ala Thr  Val Pro Pro 
    1340                 1345                 1350             


Gln Pro  Gln Tyr Ser Tyr His  Asp Ile Asn Val Tyr  Ser Leu Ala 
    1355                 1360                 1365             


Gly Leu  Ala Pro His Ile Thr  Leu Asn Pro Thr Ile  Pro Leu Phe 
    1370                 1375                 1380             


Gln Ala  His Pro Gln Leu Lys  Gln Cys Val Arg Gln  Ala Ile Glu 
    1385                 1390                 1395             


Arg Ala  Val Gln Glu Leu Val  His Pro Val Val Asp  Arg Ser Ile 
    1400                 1405                 1410             


Lys Ile  Ala Met Thr Thr Cys  Glu Gln Ile Val Arg  Lys Asp Phe 
    1415                 1420                 1425             


Ala Leu  Asp Ser Glu Glu Ser  Arg Met Arg Ile Ala  Ala His His 
    1430                 1435                 1440             


Met Met  Arg Asn Leu Thr Ala  Gly Met Ala Met Ile  Thr Cys Arg 
    1445                 1450                 1455             


Glu Pro  Leu Leu Met Ser Ile  Ser Thr Asn Leu Lys  Asn Ser Phe 
    1460                 1465                 1470             


Ala Ser  Ala Leu Arg Thr Ala  Ser Pro Gln Gln Arg  Glu Met Met 
    1475                 1480                 1485             


Asp Gln  Ala Ala Ala Gln Leu  Ala Gln Asp Asn Cys  Glu Leu Ala 
    1490                 1495                 1500             


Cys Cys  Phe Ile Gln Lys Thr  Ala Val Glu Lys Ala  Gly Pro Glu 
    1505                 1510                 1515             


Met Asp  Lys Arg Leu Ala Thr  Glu Phe Glu Leu Arg  Lys His Ala 
    1520                 1525                 1530             


Arg Gln  Glu Gly Arg Arg Tyr  Cys Asp Pro Val Val  Leu Thr Tyr 
    1535                 1540                 1545             


Gln Ala  Glu Arg Met Pro Glu  Gln Ile Arg Leu Lys  Val Gly Gly 
    1550                 1555                 1560             


Val Asp  Pro Lys Gln Leu Ala  Val Tyr Glu Glu Phe  Ala Arg Asn 
    1565                 1570                 1575             


Val Pro  Gly Phe Leu Pro Thr  Asn Asp Leu Ser Gln  Pro Thr Gly 
    1580                 1585                 1590             


Phe Leu  Ala Gln Pro Met Lys  Gln Ala Trp Ala Thr  Asp Asp Val 
    1595                 1600                 1605             


Ala Gln  Ile Tyr Asp Lys Cys  Ile Thr Glu Leu Glu  Gln His Leu 
    1610                 1615                 1620             


His Ala  Ile Pro Pro Thr Leu  Ala Met Asn Pro Gln  Ala Gln Ala 
    1625                 1630                 1635             


Leu Arg  Ser Leu Leu Glu Val  Val Val Leu Ser Arg  Asn Ser Arg 
    1640                 1645                 1650             


Asp Ala  Ile Ala Ala Leu Gly  Leu Leu Gln Lys Ala  Val Glu Gly 
    1655                 1660                 1665             


Leu Leu  Asp Ala Thr Ser Gly  Ala Asp Ala Asp Leu  Leu Leu Arg 
    1670                 1675                 1680             


Tyr Arg  Glu Cys His Leu Leu  Val Leu Lys Ala Leu  Gln Asp Gly 
    1685                 1690                 1695             


Arg Ala  Tyr Gly Ser Pro Trp  Cys Asn Lys Gln Ile  Thr Arg Cys 
    1700                 1705                 1710             


Leu Ile  Glu Cys Arg Asp Glu  Tyr Lys Tyr Asn Val  Glu Ala Val 
    1715                 1720                 1725             


Glu Leu  Leu Ile Arg Asn His  Leu Val Asn Met Gln  Gln Tyr Asp 
    1730                 1735                 1740             


Leu His  Leu Ala Gln Ser Met  Glu Asn Gly Leu Asn  Tyr Met Ala 
    1745                 1750                 1755             


Val Ala  Phe Ala Met Gln Leu  Val Lys Ile Leu Leu  Val Asp Glu 
    1760                 1765                 1770             


Arg Ser  Val Ala His Val Thr  Glu Ala Asp Leu Phe  His Thr Ile 
    1775                 1780                 1785             


Glu Thr  Leu Met Arg Ile Asn  Ala His Ser Arg Gly  Asn Ala Pro 
    1790                 1795                 1800             


Glu Gly  Leu Pro Gln Leu Met  Glu Val Val Arg Ser  Asn Tyr Glu 
    1805                 1810                 1815             


Ala Met  Ile Asp Arg Ala His  Gly Gly Pro Asn Phe  Met Met His 
    1820                 1825                 1830             


Ser Gly  Ile Ser Gln Ala Ser  Glu Tyr Asp Asp Pro  Pro Gly Leu 
    1835                 1840                 1845             


Arg Glu  Lys Ala Glu Tyr Leu  Leu Arg Glu Trp Val  Asn Leu Tyr 
    1850                 1855                 1860             


His Ser  Ala Ala Ala Gly Arg  Asp Ser Thr Lys Ala  Phe Ser Ala 
    1865                 1870                 1875             


Phe Val  Gly Gln Met His Gln  Gln Gly Ile Leu Lys  Thr Asp Asp 
    1880                 1885                 1890             


Leu Ile  Thr Arg Phe Phe Arg  Leu Cys Thr Glu Met  Cys Val Glu 
    1895                 1900                 1905             


Ile Ser  Tyr Arg Ala Gln Ala  Glu Gln Gln His Asn  Pro Ala Ala 
    1910                 1915                 1920             


Asn Pro  Thr Met Ile Arg Ala  Lys Cys Tyr His Asn  Leu Asp Ala 
    1925                 1930                 1935             


Phe Val  Arg Leu Ile Ala Leu  Leu Val Lys His Ser  Gly Glu Ala 
    1940                 1945                 1950             


Thr Asn  Thr Val Thr Lys Ile  Asn Leu Leu Asn Lys  Val Leu Gly 
    1955                 1960                 1965             


Ile Val  Val Gly Val Leu Leu  Gln Asp His Asp Val  Arg Gln Ser 
    1970                 1975                 1980             


Glu Phe  Gln Gln Leu Pro Tyr  His Arg Ile Phe Ile  Met Leu Leu 
    1985                 1990                 1995             


Leu Glu  Leu Asn Ala Pro Glu  His Val Leu Glu Thr  Ile Asn Phe 
    2000                 2005                 2010             


Gln Thr  Leu Thr Ala Phe Cys  Asn Thr Phe His Ile  Leu Arg Pro 
    2015                 2020                 2025             


Thr Lys  Ala Pro Gly Phe Val  Tyr Ala Trp Leu Glu  Leu Ile Ser 
    2030                 2035                 2040             


His Arg  Ile Phe Ile Ala Arg  Met Leu Ala His Thr  Pro Gln Gln 
    2045                 2050                 2055             


Lys Gly  Trp Pro Met Tyr Ala  Gln Leu Leu Ile Asp  Leu Phe Lys 
    2060                 2065                 2070             


Tyr Leu  Ala Pro Phe Leu Arg  Asn Val Glu Leu Thr  Lys Pro Met 
    2075                 2080                 2085             


Gln Ile  Leu Tyr Lys Gly Thr  Leu Arg Val Leu Leu  Val Leu Leu 
    2090                 2095                 2100             


His Asp  Phe Pro Glu Phe Leu  Cys Asp Tyr His Tyr  Gly Phe Cys 
    2105                 2110                 2115             


Asp Val  Ile Pro Pro Asn Cys  Ile Gln Leu Arg Asn  Leu Ile Leu 
    2120                 2125                 2130             


Ser Ala  Phe Pro Arg Asn Met  Arg Leu Pro Asp Pro  Phe Thr Pro 
    2135                 2140                 2145             


Asn Leu  Lys Val Asp Met Leu  Ser Glu Ile Asn Ile  Ala Pro Arg 
    2150                 2155                 2160             


Ile Leu  Thr Asn Phe Thr Gly  Val Met Pro Pro Gln  Phe Lys Lys 
    2165                 2170                 2175             


Asp Leu  Asp Ser Tyr Leu Lys  Thr Arg Ser Pro Val  Thr Phe Leu 
    2180                 2185                 2190             


Ser Asp  Leu Arg Ser Asn Leu  Gln Val Ser Asn Glu  Pro Gly Asn 
    2195                 2200                 2205             


Arg Tyr  Asn Leu Gln Leu Ile  Asn Ala Leu Val Leu  Tyr Val Gly 
    2210                 2215                 2220             


Thr Gln  Ala Ile Ala His Ile  His Asn Lys Gly Ser  Thr Pro Ser 
    2225                 2230                 2235             


Met Ser  Thr Ile Thr His Ser  Ala His Met Asp Ile  Phe Gln Asn 
    2240                 2245                 2250             


Leu Ala  Val Asp Leu Asp Thr  Glu Gly Arg Tyr Leu  Phe Leu Asn 
    2255                 2260                 2265             


Ala Ile  Ala Asn Gln Leu Arg  Tyr Pro Asn Ser His  Thr His Tyr 
    2270                 2275                 2280             


Phe Ser  Cys Thr Met Leu Tyr  Leu Phe Ala Glu Ala  Asn Thr Glu 
    2285                 2290                 2295             


Ala Ile  Gln Glu Gln Ile Thr  Arg Val Leu Leu Glu  Arg Leu Ile 
    2300                 2305                 2310             


Val Asn  Arg Pro His Pro Trp  Gly Leu Leu Ile Thr  Phe Ile Glu 
    2315                 2320                 2325             


Leu Ile  Lys Asn Pro Ala Phe  Lys Phe Trp Asn His  Glu Phe Val 
    2330                 2335                 2340             


His Cys  Ala Pro Glu Ile Glu  Lys Leu Phe Gln Ser  Val Ala Gln 
    2345                 2350                 2355             


Cys Cys  Met Gly Gln Lys Gln  Ala Gln Gln Val Met  Glu Gly Thr 
    2360                 2365                 2370             


Gly Ala  Ser 
    2375     


<210>  73
<211>  3664
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (425)..(2800)
<223>  

<400>  73
tgttgggagg agggtcgaag cgtatactgg ccacgcccgg gtcccgctct ctcgttgcac     60

aactgcaagc tagatctggg catcgaagga ggaacgctgc aacctccaac cccttctttc    120

tgaccaaccg ggaccagagc agtgctgggg ccggggcggg tcaccgggtg aggaccgggg    180

cggagggtgt taagttacag ggcaggagcc cgggtccctc cgcgggcagg aaggggaggg    240

cccatcgggg ctaggggaac cccggcgcag acctggggtg gggtcggaaa agctgtttca    300

tcgcccgctc ccgggccctc cgctccctcc ctccctccct ctctccctgg caggactccc    360

cgccaggcct ccccgccact ctccgcggcg cattccggga ggcagcggcc gcagcggcct    420

cgcc atg tcc cag ccc ggc cag aag ccc gcc gcc tcc ccg cgg ccc cgg     469
     Met Ser Gln Pro Gly Gln Lys Pro Ala Ala Ser Pro Arg Pro Arg        
     1               5                   10                  15         

cga gca gcc gcc gcc cgc cgc acc cat gag cat gtc agt gaa aaa acc      517
Arg Ala Ala Ala Ala Arg Arg Thr His Glu His Val Ser Glu Lys Thr         
                20                  25                  30              

agt gaa tcg cct tcc aaa cca gga gaa aag aaa gga tca gat gag aaa      565
Ser Glu Ser Pro Ser Lys Pro Gly Glu Lys Lys Gly Ser Asp Glu Lys         
            35                  40                  45                  

aaa gca gca agc ctc ggc agc agt caa tcc tcc aga acc tat gct ggt      613
Lys Ala Ala Ser Leu Gly Ser Ser Gln Ser Ser Arg Thr Tyr Ala Gly         
        50                  55                  60                      

gga aca gcc tcg gcc acc aag gtg tca gct tcc tct ggt gca acc agc      661
Gly Thr Ala Ser Ala Thr Lys Val Ser Ala Ser Ser Gly Ala Thr Ser         
    65                  70                  75                          

aag tct tcc agt atg aat ccc aca gaa acc aag gcc att cca gtc agc      709
Lys Ser Ser Ser Met Asn Pro Thr Glu Thr Lys Ala Ile Pro Val Ser         
80                  85                  90                  95          

caa cag atg gaa gga cca cat ctt cct aac aag aaa aaa cac aaa aaa      757
Gln Gln Met Glu Gly Pro His Leu Pro Asn Lys Lys Lys His Lys Lys         
                100                 105                 110             

cag gct gta aaa aca gaa cct gag aag aag tca cag tca acc aag ctg      805
Gln Ala Val Lys Thr Glu Pro Glu Lys Lys Ser Gln Ser Thr Lys Leu         
            115                 120                 125                 

tct gtg gtt cat gag aaa aaa tcc caa gaa gga aag cca aaa gaa cac      853
Ser Val Val His Glu Lys Lys Ser Gln Glu Gly Lys Pro Lys Glu His         
        130                 135                 140                     

aca gag cca aaa agc cta ccc aag cag gca tca gat aca gga agt aac      901
Thr Glu Pro Lys Ser Leu Pro Lys Gln Ala Ser Asp Thr Gly Ser Asn         
    145                 150                 155                         

gat gct cac aat aaa aaa gca gtt tcc aga tca gct gaa cag cag cca      949
Asp Ala His Asn Lys Lys Ala Val Ser Arg Ser Ala Glu Gln Gln Pro         
160                 165                 170                 175         

tca gag aaa tca aca gaa cca aag act aaa cca caa gac atg att tct      997
Ser Glu Lys Ser Thr Glu Pro Lys Thr Lys Pro Gln Asp Met Ile Ser         
                180                 185                 190             

gct ggt gga gag agt gtt gct ggt atc act gca ata tct ggc aag ccg     1045
Ala Gly Gly Glu Ser Val Ala Gly Ile Thr Ala Ile Ser Gly Lys Pro         
            195                 200                 205                 

ggt gac aag aaa aaa gaa aag aaa tca tta acc cca gct gtg cca gtt     1093
Gly Asp Lys Lys Lys Glu Lys Lys Ser Leu Thr Pro Ala Val Pro Val         
        210                 215                 220                     

gaa tct aaa ccg gat aaa cca tcg gga aag tca ggc atg gat gct gct     1141
Glu Ser Lys Pro Asp Lys Pro Ser Gly Lys Ser Gly Met Asp Ala Ala         
    225                 230                 235                         

ttg gat gac tta ata gat act tta gga gga cct gaa gaa act gaa gaa     1189
Leu Asp Asp Leu Ile Asp Thr Leu Gly Gly Pro Glu Glu Thr Glu Glu         
240                 245                 250                 255         

gaa aat aca acg tat act gga cca gaa gtt tca gat cca atg agt tcc     1237
Glu Asn Thr Thr Tyr Thr Gly Pro Glu Val Ser Asp Pro Met Ser Ser         
                260                 265                 270             

acc tac ata gag gaa ttg ggt aaa aga gaa gtc aca att cct cca aaa     1285
Thr Tyr Ile Glu Glu Leu Gly Lys Arg Glu Val Thr Ile Pro Pro Lys         
            275                 280                 285                 

tat agg gaa cta ttg gct aaa aag gaa ggg atc aca ggg cct cct gca     1333
Tyr Arg Glu Leu Leu Ala Lys Lys Glu Gly Ile Thr Gly Pro Pro Ala         
        290                 295                 300                     

gac tct tcg aaa ccc ata ggg cca gat gat gct ata gac gcc ttg tca     1381
Asp Ser Ser Lys Pro Ile Gly Pro Asp Asp Ala Ile Asp Ala Leu Ser         
    305                 310                 315                         

tct gac ttc acc tgt ggg tcg cct aca gct gct gga aag aaa act gaa     1429
Ser Asp Phe Thr Cys Gly Ser Pro Thr Ala Ala Gly Lys Lys Thr Glu         
320                 325                 330                 335         

aaa gag gaa tct aca gaa gtt tta aaa gct cag tca gca ggg aca gtc     1477
Lys Glu Glu Ser Thr Glu Val Leu Lys Ala Gln Ser Ala Gly Thr Val         
                340                 345                 350             

aga agt gct gct cca ccc caa gag aag aaa aga aag gtg gag aag gat     1525
Arg Ser Ala Ala Pro Pro Gln Glu Lys Lys Arg Lys Val Glu Lys Asp         
            355                 360                 365                 

aca atg agt gat caa gca ctc gag gct ctg tcg gct tca ctg ggc acc     1573
Thr Met Ser Asp Gln Ala Leu Glu Ala Leu Ser Ala Ser Leu Gly Thr         
        370                 375                 380                     

cgg caa gca gaa cct gag ctc gac ctc cgc tca att aag gaa gtc gat     1621
Arg Gln Ala Glu Pro Glu Leu Asp Leu Arg Ser Ile Lys Glu Val Asp         
    385                 390                 395                         

gag gca aaa gct aaa gaa gaa aaa cta gag aag tgt ggt gag gat gat     1669
Glu Ala Lys Ala Lys Glu Glu Lys Leu Glu Lys Cys Gly Glu Asp Asp         
400                 405                 410                 415         

gaa aca atc cca tct gag tac aga tta aaa cca gcc acg gat aaa gat     1717
Glu Thr Ile Pro Ser Glu Tyr Arg Leu Lys Pro Ala Thr Asp Lys Asp         
                420                 425                 430             

gga aaa cca cta ttg cca gag cct gaa gaa aaa ccc aag cct cgg agt     1765
Gly Lys Pro Leu Leu Pro Glu Pro Glu Glu Lys Pro Lys Pro Arg Ser         
            435                 440                 445                 

gaa tca gaa ctc att gat gaa ctt tca gaa gat ttt gac cgg tct gaa     1813
Glu Ser Glu Leu Ile Asp Glu Leu Ser Glu Asp Phe Asp Arg Ser Glu         
        450                 455                 460                     

tgt aaa gag aaa cca tct aag cca act gaa aag aca gaa gaa tct aag     1861
Cys Lys Glu Lys Pro Ser Lys Pro Thr Glu Lys Thr Glu Glu Ser Lys         
    465                 470                 475                         

gcc gct gct cca gct cct gtg tcg gag gct gtg tgt cgg acc tcc atg     1909
Ala Ala Ala Pro Ala Pro Val Ser Glu Ala Val Cys Arg Thr Ser Met         
480                 485                 490                 495         

tgt agt ata cag tca gca ccc cct gag ccg gct acc ttg aag ggc aca     1957
Cys Ser Ile Gln Ser Ala Pro Pro Glu Pro Ala Thr Leu Lys Gly Thr         
                500                 505                 510             

gtg cca gat gat gct gta gaa gcc ttg gct gat agc ctg ggg aaa aag     2005
Val Pro Asp Asp Ala Val Glu Ala Leu Ala Asp Ser Leu Gly Lys Lys         
            515                 520                 525                 

gaa gca gat cca gaa gat gga aaa cct gtg atg gat aaa gtc aag gag     2053
Glu Ala Asp Pro Glu Asp Gly Lys Pro Val Met Asp Lys Val Lys Glu         
        530                 535                 540                     

aag gcc aaa gaa gaa gac cgt gaa aag ctt ggt gaa aaa gaa gaa aca     2101
Lys Ala Lys Glu Glu Asp Arg Glu Lys Leu Gly Glu Lys Glu Glu Thr         
    545                 550                 555                         

att cct cct gat tat aga tta gaa gag gtc aag gat aaa gat gga aag     2149
Ile Pro Pro Asp Tyr Arg Leu Glu Glu Val Lys Asp Lys Asp Gly Lys         
560                 565                 570                 575         

cca ctc ctg cca aaa gag tct aag gaa cag ctt cca ccc atg agt gaa     2197
Pro Leu Leu Pro Lys Glu Ser Lys Glu Gln Leu Pro Pro Met Ser Glu         
                580                 585                 590             

gac ttc ctt ctg gat gct ttg tct gag gac ttc tct ggt cca caa aat     2245
Asp Phe Leu Leu Asp Ala Leu Ser Glu Asp Phe Ser Gly Pro Gln Asn         
            595                 600                 605                 

gct tca tct ctt aaa ttt gaa gat gct aaa ctt gct gct gcc atc tct     2293
Ala Ser Ser Leu Lys Phe Glu Asp Ala Lys Leu Ala Ala Ala Ile Ser         
        610                 615                 620                     

gaa gtg gtt tcc caa acc cca gct tca acg acc caa gct gga gcc cca     2341
Glu Val Val Ser Gln Thr Pro Ala Ser Thr Thr Gln Ala Gly Ala Pro         
    625                 630                 635                         

ccc cgt gat acc tcg cag agt gac aaa gac ctc gat gat gcc ttg gat     2389
Pro Arg Asp Thr Ser Gln Ser Asp Lys Asp Leu Asp Asp Ala Leu Asp         
640                 645                 650                 655         

aaa ctc tct gac agt cta gga caa agg cag cct gac cca gat gag aac     2437
Lys Leu Ser Asp Ser Leu Gly Gln Arg Gln Pro Asp Pro Asp Glu Asn         
                660                 665                 670             

aaa cca atg gaa gat aaa gta aag gaa aaa gct aaa gct gaa cat aga     2485
Lys Pro Met Glu Asp Lys Val Lys Glu Lys Ala Lys Ala Glu His Arg         
            675                 680                 685                 

gac aag ctt gga gaa aga gat gac act atc cca cct gaa tac aga cat     2533
Asp Lys Leu Gly Glu Arg Asp Asp Thr Ile Pro Pro Glu Tyr Arg His         
        690                 695                 700                     

ctc ctg gat gat aat gga cag gac aaa cca gtg aag cca cct aca aag     2581
Leu Leu Asp Asp Asn Gly Gln Asp Lys Pro Val Lys Pro Pro Thr Lys         
    705                 710                 715                         

aaa tca gag gat tca aag aaa cct gca gat gac caa gac ccc att gat     2629
Lys Ser Glu Asp Ser Lys Lys Pro Ala Asp Asp Gln Asp Pro Ile Asp         
720                 725                 730                 735         

gct ctc tca gga gat ctg gac agc tgt ccc tcc act aca gaa acc tca     2677
Ala Leu Ser Gly Asp Leu Asp Ser Cys Pro Ser Thr Thr Glu Thr Ser         
                740                 745                 750             

cag aac aca gca aag gat aag tgc aag aag gct gct tcc agc tcc aaa     2725
Gln Asn Thr Ala Lys Asp Lys Cys Lys Lys Ala Ala Ser Ser Ser Lys         
            755                 760                 765                 

gca cct aag aat gga ggt aaa gcg aag gat tca gca aag aca aca gag     2773
Ala Pro Lys Asn Gly Gly Lys Ala Lys Asp Ser Ala Lys Thr Thr Glu         
        770                 775                 780                     

gaa act tcc aag cca aaa gat gac taa agaaatacaa gttaaggtat           2820
Glu Thr Ser Lys Pro Lys Asp Asp                                         
    785                 790                                             

ctggtatctg catgtaaaat cttcagctgg tggatggtga cttttgaaga acaaaaggct   2880

ttggcaacag aaaacaattg ttctgggtga tttctagaat ggtttttgtt gagtctctga   2940

acatcctaaa tattggtttg ttattctttt ccagaaagaa aatgaatttg actggttcac   3000

ctgtgtactg agtattgata aactttgaat ttttttaatt gccttcaatt gggagagaaa   3060

gctttatatt tgtgtgagga cttctgcatc ttacagtcag cacagaacac actgagactt   3120

gaatcaagtc agcaacagag caaaataaag gttagataag tccttgtgta gcaaatttcg   3180

agcataagaa ataaaatcta attaattctt agggtactca tctgacttga actctgttgg   3240

tttactgtgt tagtaaactg tgctttctat tatctataca taaaacctga gcagcaactg   3300

tgtctttaga gctattgcca cattagcctt tgcactgtat agcgtctggc tttatggaac   3360

ttaagtttac caaatataaa aagaaacttc tgcttttaaa aaaattatat atatatatta   3420

aatttgaaac ctgcatttct cccacagcaa tgtaagaagt aggctctgat gtcctaccac   3480

tttgaatggt tttctaatat cttaatgaat agttcctgaa cattgcactg atatcatcga   3540

ttagaatttt gatatttaat ttcatcttta tttcctggta gagaatgcac gacaagatgt   3600

caggtacata acataaaaca gattgggaat ttattgtttc caaagggcat gcccttcctt   3660

agca                                                                3664


<210>  74
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ser Gln Pro Gly Gln Lys Pro Ala Ala Ser Pro Arg Pro Arg Arg 
1               5                   10                  15      


Ala Ala Ala Ala Arg Arg Thr His Glu His Val Ser Glu Lys Thr Ser 
            20                  25                  30          


Glu Ser Pro Ser Lys Pro Gly Glu Lys Lys Gly Ser Asp Glu Lys Lys 
        35                  40                  45              


Ala Ala Ser Leu Gly Ser Ser Gln Ser Ser Arg Thr Tyr Ala Gly Gly 
    50                  55                  60                  


Thr Ala Ser Ala Thr Lys Val Ser Ala Ser Ser Gly Ala Thr Ser Lys 
65                  70                  75                  80  


Ser Ser Ser Met Asn Pro Thr Glu Thr Lys Ala Ile Pro Val Ser Gln 
                85                  90                  95      


Gln Met Glu Gly Pro His Leu Pro Asn Lys Lys Lys His Lys Lys Gln 
            100                 105                 110         


Ala Val Lys Thr Glu Pro Glu Lys Lys Ser Gln Ser Thr Lys Leu Ser 
        115                 120                 125             


Val Val His Glu Lys Lys Ser Gln Glu Gly Lys Pro Lys Glu His Thr 
    130                 135                 140                 


Glu Pro Lys Ser Leu Pro Lys Gln Ala Ser Asp Thr Gly Ser Asn Asp 
145                 150                 155                 160 


Ala His Asn Lys Lys Ala Val Ser Arg Ser Ala Glu Gln Gln Pro Ser 
                165                 170                 175     


Glu Lys Ser Thr Glu Pro Lys Thr Lys Pro Gln Asp Met Ile Ser Ala 
            180                 185                 190         


Gly Gly Glu Ser Val Ala Gly Ile Thr Ala Ile Ser Gly Lys Pro Gly 
        195                 200                 205             


Asp Lys Lys Lys Glu Lys Lys Ser Leu Thr Pro Ala Val Pro Val Glu 
    210                 215                 220                 


Ser Lys Pro Asp Lys Pro Ser Gly Lys Ser Gly Met Asp Ala Ala Leu 
225                 230                 235                 240 


Asp Asp Leu Ile Asp Thr Leu Gly Gly Pro Glu Glu Thr Glu Glu Glu 
                245                 250                 255     


Asn Thr Thr Tyr Thr Gly Pro Glu Val Ser Asp Pro Met Ser Ser Thr 
            260                 265                 270         


Tyr Ile Glu Glu Leu Gly Lys Arg Glu Val Thr Ile Pro Pro Lys Tyr 
        275                 280                 285             


Arg Glu Leu Leu Ala Lys Lys Glu Gly Ile Thr Gly Pro Pro Ala Asp 
    290                 295                 300                 


Ser Ser Lys Pro Ile Gly Pro Asp Asp Ala Ile Asp Ala Leu Ser Ser 
305                 310                 315                 320 


Asp Phe Thr Cys Gly Ser Pro Thr Ala Ala Gly Lys Lys Thr Glu Lys 
                325                 330                 335     


Glu Glu Ser Thr Glu Val Leu Lys Ala Gln Ser Ala Gly Thr Val Arg 
            340                 345                 350         


Ser Ala Ala Pro Pro Gln Glu Lys Lys Arg Lys Val Glu Lys Asp Thr 
        355                 360                 365             


Met Ser Asp Gln Ala Leu Glu Ala Leu Ser Ala Ser Leu Gly Thr Arg 
    370                 375                 380                 


Gln Ala Glu Pro Glu Leu Asp Leu Arg Ser Ile Lys Glu Val Asp Glu 
385                 390                 395                 400 


Ala Lys Ala Lys Glu Glu Lys Leu Glu Lys Cys Gly Glu Asp Asp Glu 
                405                 410                 415     


Thr Ile Pro Ser Glu Tyr Arg Leu Lys Pro Ala Thr Asp Lys Asp Gly 
            420                 425                 430         


Lys Pro Leu Leu Pro Glu Pro Glu Glu Lys Pro Lys Pro Arg Ser Glu 
        435                 440                 445             


Ser Glu Leu Ile Asp Glu Leu Ser Glu Asp Phe Asp Arg Ser Glu Cys 
    450                 455                 460                 


Lys Glu Lys Pro Ser Lys Pro Thr Glu Lys Thr Glu Glu Ser Lys Ala 
465                 470                 475                 480 


Ala Ala Pro Ala Pro Val Ser Glu Ala Val Cys Arg Thr Ser Met Cys 
                485                 490                 495     


Ser Ile Gln Ser Ala Pro Pro Glu Pro Ala Thr Leu Lys Gly Thr Val 
            500                 505                 510         


Pro Asp Asp Ala Val Glu Ala Leu Ala Asp Ser Leu Gly Lys Lys Glu 
        515                 520                 525             


Ala Asp Pro Glu Asp Gly Lys Pro Val Met Asp Lys Val Lys Glu Lys 
    530                 535                 540                 


Ala Lys Glu Glu Asp Arg Glu Lys Leu Gly Glu Lys Glu Glu Thr Ile 
545                 550                 555                 560 


Pro Pro Asp Tyr Arg Leu Glu Glu Val Lys Asp Lys Asp Gly Lys Pro 
                565                 570                 575     


Leu Leu Pro Lys Glu Ser Lys Glu Gln Leu Pro Pro Met Ser Glu Asp 
            580                 585                 590         


Phe Leu Leu Asp Ala Leu Ser Glu Asp Phe Ser Gly Pro Gln Asn Ala 
        595                 600                 605             


Ser Ser Leu Lys Phe Glu Asp Ala Lys Leu Ala Ala Ala Ile Ser Glu 
    610                 615                 620                 


Val Val Ser Gln Thr Pro Ala Ser Thr Thr Gln Ala Gly Ala Pro Pro 
625                 630                 635                 640 


Arg Asp Thr Ser Gln Ser Asp Lys Asp Leu Asp Asp Ala Leu Asp Lys 
                645                 650                 655     


Leu Ser Asp Ser Leu Gly Gln Arg Gln Pro Asp Pro Asp Glu Asn Lys 
            660                 665                 670         


Pro Met Glu Asp Lys Val Lys Glu Lys Ala Lys Ala Glu His Arg Asp 
        675                 680                 685             


Lys Leu Gly Glu Arg Asp Asp Thr Ile Pro Pro Glu Tyr Arg His Leu 
    690                 695                 700                 


Leu Asp Asp Asn Gly Gln Asp Lys Pro Val Lys Pro Pro Thr Lys Lys 
705                 710                 715                 720 


Ser Glu Asp Ser Lys Lys Pro Ala Asp Asp Gln Asp Pro Ile Asp Ala 
                725                 730                 735     


Leu Ser Gly Asp Leu Asp Ser Cys Pro Ser Thr Thr Glu Thr Ser Gln 
            740                 745                 750         


Asn Thr Ala Lys Asp Lys Cys Lys Lys Ala Ala Ser Ser Ser Lys Ala 
        755                 760                 765             


Pro Lys Asn Gly Gly Lys Ala Lys Asp Ser Ala Lys Thr Thr Glu Glu 
    770                 775                 780                 


Thr Ser Lys Pro Lys Asp Asp 
785                 790     


<210>  75
<211>  3598
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (425)..(2734)
<223>  

<400>  75
tgttgggagg agggtcgaag cgtatactgg ccacgcccgg gtcccgctct ctcgttgcac     60

aactgcaagc tagatctggg catcgaagga ggaacgctgc aacctccaac cccttctttc    120

tgaccaaccg ggaccagagc agtgctgggg ccggggcggg tcaccgggtg aggaccgggg    180

cggagggtgt taagttacag ggcaggagcc cgggtccctc cgcgggcagg aaggggaggg    240

cccatcgggg ctaggggaac cccggcgcag acctggggtg gggtcggaaa agctgtttca    300

tcgcccgctc ccgggccctc cgctccctcc ctccctccct ctctccctgg caggactccc    360

cgccaggcct ccccgccact ctccgcggcg cattccggga ggcagcggcc gcagcggcct    420

cgcc atg tcc cag ccc ggc cag aag ccc gcc gcc tcc ccg cgg ccc cgg     469
     Met Ser Gln Pro Gly Gln Lys Pro Ala Ala Ser Pro Arg Pro Arg        
     1               5                   10                  15         

cga gca gcc gcc gcc cgc cgc acc cat gag cat gtc agt gaa aaa acc      517
Arg Ala Ala Ala Ala Arg Arg Thr His Glu His Val Ser Glu Lys Thr         
                20                  25                  30              

agt gaa tcg cct tcc aaa cca gga gaa aag aaa gga tca gat gag aaa      565
Ser Glu Ser Pro Ser Lys Pro Gly Glu Lys Lys Gly Ser Asp Glu Lys         
            35                  40                  45                  

aaa gca gca agc ctc ggc agc agt caa tcc tcc aga acc tat gct ggt      613
Lys Ala Ala Ser Leu Gly Ser Ser Gln Ser Ser Arg Thr Tyr Ala Gly         
        50                  55                  60                      

gga aca gcc tcg gcc acc aag gtg tca gct tcc tct ggt gca acc agc      661
Gly Thr Ala Ser Ala Thr Lys Val Ser Ala Ser Ser Gly Ala Thr Ser         
    65                  70                  75                          

aag tct tcc agt atg aat ccc aca gaa acc aag gct gta aaa aca gaa      709
Lys Ser Ser Ser Met Asn Pro Thr Glu Thr Lys Ala Val Lys Thr Glu         
80                  85                  90                  95          

cct gag aag aag tca cag tca acc aag ctg tct gtg gtt cat gag aaa      757
Pro Glu Lys Lys Ser Gln Ser Thr Lys Leu Ser Val Val His Glu Lys         
                100                 105                 110             

aaa tcc caa gaa gga aag cca aaa gaa cac aca gag cca aaa agc cta      805
Lys Ser Gln Glu Gly Lys Pro Lys Glu His Thr Glu Pro Lys Ser Leu         
            115                 120                 125                 

ccc aag cag gca tca gat aca gga agt aac gat gct cac aat aaa aaa      853
Pro Lys Gln Ala Ser Asp Thr Gly Ser Asn Asp Ala His Asn Lys Lys         
        130                 135                 140                     

gca gtt tcc aga tca gct gaa cag cag cca tca gag aaa tca aca gaa      901
Ala Val Ser Arg Ser Ala Glu Gln Gln Pro Ser Glu Lys Ser Thr Glu         
    145                 150                 155                         

cca aag act aaa cca caa gac atg att tct gct ggt gga gag agt gtt      949
Pro Lys Thr Lys Pro Gln Asp Met Ile Ser Ala Gly Gly Glu Ser Val         
160                 165                 170                 175         

gct ggt atc act gca ata tct ggc aag ccg ggt gac aag aaa aaa gaa      997
Ala Gly Ile Thr Ala Ile Ser Gly Lys Pro Gly Asp Lys Lys Lys Glu         
                180                 185                 190             

aag aaa tca tta acc cca gct gtg cca gtt gaa tct aaa ccg gat aaa     1045
Lys Lys Ser Leu Thr Pro Ala Val Pro Val Glu Ser Lys Pro Asp Lys         
            195                 200                 205                 

cca tcg gga aag tca ggc atg gat gct gct ttg gat gac tta ata gat     1093
Pro Ser Gly Lys Ser Gly Met Asp Ala Ala Leu Asp Asp Leu Ile Asp         
        210                 215                 220                     

act tta gga gga cct gaa gaa act gaa gaa gaa aat aca acg tat act     1141
Thr Leu Gly Gly Pro Glu Glu Thr Glu Glu Glu Asn Thr Thr Tyr Thr         
    225                 230                 235                         

gga cca gaa gtt tca gat cca atg agt tcc acc tac ata gag gaa ttg     1189
Gly Pro Glu Val Ser Asp Pro Met Ser Ser Thr Tyr Ile Glu Glu Leu         
240                 245                 250                 255         

ggt aaa aga gaa gtc aca att cct cca aaa tat agg gaa cta ttg gct     1237
Gly Lys Arg Glu Val Thr Ile Pro Pro Lys Tyr Arg Glu Leu Leu Ala         
                260                 265                 270             

aaa aag gaa ggg atc aca ggg cct cct gca gac tct tcg aaa ccc ata     1285
Lys Lys Glu Gly Ile Thr Gly Pro Pro Ala Asp Ser Ser Lys Pro Ile         
            275                 280                 285                 

ggg cca gat gat gct ata gac gcc ttg tca tct gac ttc acc tgt ggg     1333
Gly Pro Asp Asp Ala Ile Asp Ala Leu Ser Ser Asp Phe Thr Cys Gly         
        290                 295                 300                     

tcg cct aca gct gct gga aag aaa act gaa aaa gag gaa tct aca gaa     1381
Ser Pro Thr Ala Ala Gly Lys Lys Thr Glu Lys Glu Glu Ser Thr Glu         
    305                 310                 315                         

gtt tta aaa gct cag tca gca ggg aca gtc aga agt gct gct cca ccc     1429
Val Leu Lys Ala Gln Ser Ala Gly Thr Val Arg Ser Ala Ala Pro Pro         
320                 325                 330                 335         

caa gag aag aaa aga aag gtg gag aag gat aca atg agt gat caa gca     1477
Gln Glu Lys Lys Arg Lys Val Glu Lys Asp Thr Met Ser Asp Gln Ala         
                340                 345                 350             

ctc gag gct ctg tcg gct tca ctg ggc acc cgg caa gca gaa cct gag     1525
Leu Glu Ala Leu Ser Ala Ser Leu Gly Thr Arg Gln Ala Glu Pro Glu         
            355                 360                 365                 

ctc gac ctc cgc tca att aag gaa gtc gat gag gca aaa gct aaa gaa     1573
Leu Asp Leu Arg Ser Ile Lys Glu Val Asp Glu Ala Lys Ala Lys Glu         
        370                 375                 380                     

gaa aaa cta gag aag tgt ggt gag gat gat gaa aca atc cca tct gag     1621
Glu Lys Leu Glu Lys Cys Gly Glu Asp Asp Glu Thr Ile Pro Ser Glu         
    385                 390                 395                         

tac aga tta aaa cca gcc acg gat aaa gat gga aaa cca cta ttg cca     1669
Tyr Arg Leu Lys Pro Ala Thr Asp Lys Asp Gly Lys Pro Leu Leu Pro         
400                 405                 410                 415         

gag cct gaa gaa aaa ccc aag cct cgg agt gaa tca gaa ctc att gat     1717
Glu Pro Glu Glu Lys Pro Lys Pro Arg Ser Glu Ser Glu Leu Ile Asp         
                420                 425                 430             

gaa ctt tca gaa gat ttt gac cgg tct gaa tgt aaa gag aaa cca tct     1765
Glu Leu Ser Glu Asp Phe Asp Arg Ser Glu Cys Lys Glu Lys Pro Ser         
            435                 440                 445                 

aag cca act gaa aag aca gaa gaa tct aag gcc gct gct cca gct cct     1813
Lys Pro Thr Glu Lys Thr Glu Glu Ser Lys Ala Ala Ala Pro Ala Pro         
        450                 455                 460                     

gtg tcg gag gct gtg tgt cgg acc tcc atg tgt agt ata cag tca gca     1861
Val Ser Glu Ala Val Cys Arg Thr Ser Met Cys Ser Ile Gln Ser Ala         
    465                 470                 475                         

ccc cct gag ccg gct acc ttg aag ggc aca gtg cca gat gat gct gta     1909
Pro Pro Glu Pro Ala Thr Leu Lys Gly Thr Val Pro Asp Asp Ala Val         
480                 485                 490                 495         

gaa gcc ttg gct gat agc ctg ggg aaa aag gaa gca gat cca gaa gat     1957
Glu Ala Leu Ala Asp Ser Leu Gly Lys Lys Glu Ala Asp Pro Glu Asp         
                500                 505                 510             

gga aaa cct gtg atg gat aaa gtc aag gag aag gcc aaa gaa gaa gac     2005
Gly Lys Pro Val Met Asp Lys Val Lys Glu Lys Ala Lys Glu Glu Asp         
            515                 520                 525                 

cgt gaa aag ctt ggt gaa aaa gaa gaa aca att cct cct gat tat aga     2053
Arg Glu Lys Leu Gly Glu Lys Glu Glu Thr Ile Pro Pro Asp Tyr Arg         
        530                 535                 540                     

tta gaa gag gtc aag gat aaa gat gga aag cca ctc ctg cca aaa gag     2101
Leu Glu Glu Val Lys Asp Lys Asp Gly Lys Pro Leu Leu Pro Lys Glu         
    545                 550                 555                         

tct aag gaa cag ctt cca ccc atg agt gaa gac ttc ctt ctg gat gct     2149
Ser Lys Glu Gln Leu Pro Pro Met Ser Glu Asp Phe Leu Leu Asp Ala         
560                 565                 570                 575         

ttg tct gag gac ttc tct ggt cca caa aat gct tca tct ctt aaa ttt     2197
Leu Ser Glu Asp Phe Ser Gly Pro Gln Asn Ala Ser Ser Leu Lys Phe         
                580                 585                 590             

gaa gat gct aaa ctt gct gct gcc atc tct gaa gtg gtt tcc caa acc     2245
Glu Asp Ala Lys Leu Ala Ala Ala Ile Ser Glu Val Val Ser Gln Thr         
            595                 600                 605                 

cca gct tca acg acc caa gct gga gcc cca ccc cgt gat acc tcg cag     2293
Pro Ala Ser Thr Thr Gln Ala Gly Ala Pro Pro Arg Asp Thr Ser Gln         
        610                 615                 620                     

agt gac aaa gac ctc gat gat gcc ttg gat aaa ctc tct gac agt cta     2341
Ser Asp Lys Asp Leu Asp Asp Ala Leu Asp Lys Leu Ser Asp Ser Leu         
    625                 630                 635                         

gga caa agg cag cct gac cca gat gag aac aaa cca atg gaa gat aaa     2389
Gly Gln Arg Gln Pro Asp Pro Asp Glu Asn Lys Pro Met Glu Asp Lys         
640                 645                 650                 655         

gta aag gaa aaa gct aaa gct gaa cat aga gac aag ctt gga gaa aga     2437
Val Lys Glu Lys Ala Lys Ala Glu His Arg Asp Lys Leu Gly Glu Arg         
                660                 665                 670             

gat gac act atc cca cct gaa tac aga cat ctc ctg gat gat aat gga     2485
Asp Asp Thr Ile Pro Pro Glu Tyr Arg His Leu Leu Asp Asp Asn Gly         
            675                 680                 685                 

cag gac aaa cca gtg aag cca cct aca aag aaa tca gag gat tca aag     2533
Gln Asp Lys Pro Val Lys Pro Pro Thr Lys Lys Ser Glu Asp Ser Lys         
        690                 695                 700                     

aaa cct gca gat gac caa gac ccc att gat gct ctc tca gga gat ctg     2581
Lys Pro Ala Asp Asp Gln Asp Pro Ile Asp Ala Leu Ser Gly Asp Leu         
    705                 710                 715                         

gac agc tgt ccc tcc act aca gaa acc tca cag aac aca gca aag gat     2629
Asp Ser Cys Pro Ser Thr Thr Glu Thr Ser Gln Asn Thr Ala Lys Asp         
720                 725                 730                 735         

aag tgc aag aag gct gct tcc agc tcc aaa gca cct aag aat gga ggt     2677
Lys Cys Lys Lys Ala Ala Ser Ser Ser Lys Ala Pro Lys Asn Gly Gly         
                740                 745                 750             

aaa gcg aag gat tca gca aag aca aca gag gaa act tcc aag cca aaa     2725
Lys Ala Lys Asp Ser Ala Lys Thr Thr Glu Glu Thr Ser Lys Pro Lys         
            755                 760                 765                 

gat gac taa agaaatacaa gttaaggtat ctggtatctg catgtaaaat             2774
Asp Asp                                                                 
                                                                        

cttcagctgg tggatggtga cttttgaaga acaaaaggct ttggcaacag aaaacaattg   2834

ttctgggtga tttctagaat ggtttttgtt gagtctctga acatcctaaa tattggtttg   2894

ttattctttt ccagaaagaa aatgaatttg actggttcac ctgtgtactg agtattgata   2954

aactttgaat ttttttaatt gccttcaatt gggagagaaa gctttatatt tgtgtgagga   3014

cttctgcatc ttacagtcag cacagaacac actgagactt gaatcaagtc agcaacagag   3074

caaaataaag gttagataag tccttgtgta gcaaatttcg agcataagaa ataaaatcta   3134

attaattctt agggtactca tctgacttga actctgttgg tttactgtgt tagtaaactg   3194

tgctttctat tatctataca taaaacctga gcagcaactg tgtctttaga gctattgcca   3254

cattagcctt tgcactgtat agcgtctggc tttatggaac ttaagtttac caaatataaa   3314

aagaaacttc tgcttttaaa aaaattatat atatatatta aatttgaaac ctgcatttct   3374

cccacagcaa tgtaagaagt aggctctgat gtcctaccac tttgaatggt tttctaatat   3434

cttaatgaat agttcctgaa cattgcactg atatcatcga ttagaatttt gatatttaat   3494

ttcatcttta tttcctggta gagaatgcac gacaagatgt caggtacata acataaaaca   3554

gattgggaat ttattgtttc caaagggcat gcccttcctt agca                    3598


<210>  76
<211>  769
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ser Gln Pro Gly Gln Lys Pro Ala Ala Ser Pro Arg Pro Arg Arg 
1               5                   10                  15      


Ala Ala Ala Ala Arg Arg Thr His Glu His Val Ser Glu Lys Thr Ser 
            20                  25                  30          


Glu Ser Pro Ser Lys Pro Gly Glu Lys Lys Gly Ser Asp Glu Lys Lys 
        35                  40                  45              


Ala Ala Ser Leu Gly Ser Ser Gln Ser Ser Arg Thr Tyr Ala Gly Gly 
    50                  55                  60                  


Thr Ala Ser Ala Thr Lys Val Ser Ala Ser Ser Gly Ala Thr Ser Lys 
65                  70                  75                  80  


Ser Ser Ser Met Asn Pro Thr Glu Thr Lys Ala Val Lys Thr Glu Pro 
                85                  90                  95      


Glu Lys Lys Ser Gln Ser Thr Lys Leu Ser Val Val His Glu Lys Lys 
            100                 105                 110         


Ser Gln Glu Gly Lys Pro Lys Glu His Thr Glu Pro Lys Ser Leu Pro 
        115                 120                 125             


Lys Gln Ala Ser Asp Thr Gly Ser Asn Asp Ala His Asn Lys Lys Ala 
    130                 135                 140                 


Val Ser Arg Ser Ala Glu Gln Gln Pro Ser Glu Lys Ser Thr Glu Pro 
145                 150                 155                 160 


Lys Thr Lys Pro Gln Asp Met Ile Ser Ala Gly Gly Glu Ser Val Ala 
                165                 170                 175     


Gly Ile Thr Ala Ile Ser Gly Lys Pro Gly Asp Lys Lys Lys Glu Lys 
            180                 185                 190         


Lys Ser Leu Thr Pro Ala Val Pro Val Glu Ser Lys Pro Asp Lys Pro 
        195                 200                 205             


Ser Gly Lys Ser Gly Met Asp Ala Ala Leu Asp Asp Leu Ile Asp Thr 
    210                 215                 220                 


Leu Gly Gly Pro Glu Glu Thr Glu Glu Glu Asn Thr Thr Tyr Thr Gly 
225                 230                 235                 240 


Pro Glu Val Ser Asp Pro Met Ser Ser Thr Tyr Ile Glu Glu Leu Gly 
                245                 250                 255     


Lys Arg Glu Val Thr Ile Pro Pro Lys Tyr Arg Glu Leu Leu Ala Lys 
            260                 265                 270         


Lys Glu Gly Ile Thr Gly Pro Pro Ala Asp Ser Ser Lys Pro Ile Gly 
        275                 280                 285             


Pro Asp Asp Ala Ile Asp Ala Leu Ser Ser Asp Phe Thr Cys Gly Ser 
    290                 295                 300                 


Pro Thr Ala Ala Gly Lys Lys Thr Glu Lys Glu Glu Ser Thr Glu Val 
305                 310                 315                 320 


Leu Lys Ala Gln Ser Ala Gly Thr Val Arg Ser Ala Ala Pro Pro Gln 
                325                 330                 335     


Glu Lys Lys Arg Lys Val Glu Lys Asp Thr Met Ser Asp Gln Ala Leu 
            340                 345                 350         


Glu Ala Leu Ser Ala Ser Leu Gly Thr Arg Gln Ala Glu Pro Glu Leu 
        355                 360                 365             


Asp Leu Arg Ser Ile Lys Glu Val Asp Glu Ala Lys Ala Lys Glu Glu 
    370                 375                 380                 


Lys Leu Glu Lys Cys Gly Glu Asp Asp Glu Thr Ile Pro Ser Glu Tyr 
385                 390                 395                 400 


Arg Leu Lys Pro Ala Thr Asp Lys Asp Gly Lys Pro Leu Leu Pro Glu 
                405                 410                 415     


Pro Glu Glu Lys Pro Lys Pro Arg Ser Glu Ser Glu Leu Ile Asp Glu 
            420                 425                 430         


Leu Ser Glu Asp Phe Asp Arg Ser Glu Cys Lys Glu Lys Pro Ser Lys 
        435                 440                 445             


Pro Thr Glu Lys Thr Glu Glu Ser Lys Ala Ala Ala Pro Ala Pro Val 
    450                 455                 460                 


Ser Glu Ala Val Cys Arg Thr Ser Met Cys Ser Ile Gln Ser Ala Pro 
465                 470                 475                 480 


Pro Glu Pro Ala Thr Leu Lys Gly Thr Val Pro Asp Asp Ala Val Glu 
                485                 490                 495     


Ala Leu Ala Asp Ser Leu Gly Lys Lys Glu Ala Asp Pro Glu Asp Gly 
            500                 505                 510         


Lys Pro Val Met Asp Lys Val Lys Glu Lys Ala Lys Glu Glu Asp Arg 
        515                 520                 525             


Glu Lys Leu Gly Glu Lys Glu Glu Thr Ile Pro Pro Asp Tyr Arg Leu 
    530                 535                 540                 


Glu Glu Val Lys Asp Lys Asp Gly Lys Pro Leu Leu Pro Lys Glu Ser 
545                 550                 555                 560 


Lys Glu Gln Leu Pro Pro Met Ser Glu Asp Phe Leu Leu Asp Ala Leu 
                565                 570                 575     


Ser Glu Asp Phe Ser Gly Pro Gln Asn Ala Ser Ser Leu Lys Phe Glu 
            580                 585                 590         


Asp Ala Lys Leu Ala Ala Ala Ile Ser Glu Val Val Ser Gln Thr Pro 
        595                 600                 605             


Ala Ser Thr Thr Gln Ala Gly Ala Pro Pro Arg Asp Thr Ser Gln Ser 
    610                 615                 620                 


Asp Lys Asp Leu Asp Asp Ala Leu Asp Lys Leu Ser Asp Ser Leu Gly 
625                 630                 635                 640 


Gln Arg Gln Pro Asp Pro Asp Glu Asn Lys Pro Met Glu Asp Lys Val 
                645                 650                 655     


Lys Glu Lys Ala Lys Ala Glu His Arg Asp Lys Leu Gly Glu Arg Asp 
            660                 665                 670         


Asp Thr Ile Pro Pro Glu Tyr Arg His Leu Leu Asp Asp Asn Gly Gln 
        675                 680                 685             


Asp Lys Pro Val Lys Pro Pro Thr Lys Lys Ser Glu Asp Ser Lys Lys 
    690                 695                 700                 


Pro Ala Asp Asp Gln Asp Pro Ile Asp Ala Leu Ser Gly Asp Leu Asp 
705                 710                 715                 720 


Ser Cys Pro Ser Thr Thr Glu Thr Ser Gln Asn Thr Ala Lys Asp Lys 
                725                 730                 735     


Cys Lys Lys Ala Ala Ser Ser Ser Lys Ala Pro Lys Asn Gly Gly Lys 
            740                 745                 750         


Ala Lys Asp Ser Ala Lys Thr Thr Glu Glu Thr Ser Lys Pro Lys Asp 
        755                 760                 765             


Asp 
    


<210>  77
<211>  3541
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (425)..(2677)
<223>  

<400>  77
tgttgggagg agggtcgaag cgtatactgg ccacgcccgg gtcccgctct ctcgttgcac     60

aactgcaagc tagatctggg catcgaagga ggaacgctgc aacctccaac cccttctttc    120

tgaccaaccg ggaccagagc agtgctgggg ccggggcggg tcaccgggtg aggaccgggg    180

cggagggtgt taagttacag ggcaggagcc cgggtccctc cgcgggcagg aaggggaggg    240

cccatcgggg ctaggggaac cccggcgcag acctggggtg gggtcggaaa agctgtttca    300

tcgcccgctc ccgggccctc cgctccctcc ctccctccct ctctccctgg caggactccc    360

cgccaggcct ccccgccact ctccgcggcg cattccggga ggcagcggcc gcagcggcct    420

cgcc atg tcc cag ccc ggc cag aag ccc gcc gcc tcc ccg cgg ccc cgg     469
     Met Ser Gln Pro Gly Gln Lys Pro Ala Ala Ser Pro Arg Pro Arg        
     1               5                   10                  15         

cga gca gcc gcc gcc cgc cgc acc cat gag cat gtc agt gaa aaa acc      517
Arg Ala Ala Ala Ala Arg Arg Thr His Glu His Val Ser Glu Lys Thr         
                20                  25                  30              

agt gaa tcg cct tcc aaa cca gga gaa aag aaa gga tca gat gag aaa      565
Ser Glu Ser Pro Ser Lys Pro Gly Glu Lys Lys Gly Ser Asp Glu Lys         
            35                  40                  45                  

aaa gca gca agc ctc ggc agc agt caa tcc tcc aga acc tat gct ggt      613
Lys Ala Ala Ser Leu Gly Ser Ser Gln Ser Ser Arg Thr Tyr Ala Gly         
        50                  55                  60                      

gga aca gcc tcg gcc acc aag gtg tca gct tcc tct ggt gca acc agc      661
Gly Thr Ala Ser Ala Thr Lys Val Ser Ala Ser Ser Gly Ala Thr Ser         
    65                  70                  75                          

aag tct tcc agt atg aat ccc aca gaa acc aag gct gta aaa aca gaa      709
Lys Ser Ser Ser Met Asn Pro Thr Glu Thr Lys Ala Val Lys Thr Glu         
80                  85                  90                  95          

cct gag aag aag tca cag tca acc aag cca aaa agc cta ccc aag cag      757
Pro Glu Lys Lys Ser Gln Ser Thr Lys Pro Lys Ser Leu Pro Lys Gln         
                100                 105                 110             

gca tca gat aca gga agt aac gat gct cac aat aaa aaa gca gtt tcc      805
Ala Ser Asp Thr Gly Ser Asn Asp Ala His Asn Lys Lys Ala Val Ser         
            115                 120                 125                 

aga tca gct gaa cag cag cca tca gag aaa tca aca gaa cca aag act      853
Arg Ser Ala Glu Gln Gln Pro Ser Glu Lys Ser Thr Glu Pro Lys Thr         
        130                 135                 140                     

aaa cca caa gac atg att tct gct ggt gga gag agt gtt gct ggt atc      901
Lys Pro Gln Asp Met Ile Ser Ala Gly Gly Glu Ser Val Ala Gly Ile         
    145                 150                 155                         

act gca ata tct ggc aag ccg ggt gac aag aaa aaa gaa aag aaa tca      949
Thr Ala Ile Ser Gly Lys Pro Gly Asp Lys Lys Lys Glu Lys Lys Ser         
160                 165                 170                 175         

tta acc cca gct gtg cca gtt gaa tct aaa ccg gat aaa cca tcg gga      997
Leu Thr Pro Ala Val Pro Val Glu Ser Lys Pro Asp Lys Pro Ser Gly         
                180                 185                 190             

aag tca ggc atg gat gct gct ttg gat gac tta ata gat act tta gga     1045
Lys Ser Gly Met Asp Ala Ala Leu Asp Asp Leu Ile Asp Thr Leu Gly         
            195                 200                 205                 

gga cct gaa gaa act gaa gaa gaa aat aca acg tat act gga cca gaa     1093
Gly Pro Glu Glu Thr Glu Glu Glu Asn Thr Thr Tyr Thr Gly Pro Glu         
        210                 215                 220                     

gtt tca gat cca atg agt tcc acc tac ata gag gaa ttg ggt aaa aga     1141
Val Ser Asp Pro Met Ser Ser Thr Tyr Ile Glu Glu Leu Gly Lys Arg         
    225                 230                 235                         

gaa gtc aca att cct cca aaa tat agg gaa cta ttg gct aaa aag gaa     1189
Glu Val Thr Ile Pro Pro Lys Tyr Arg Glu Leu Leu Ala Lys Lys Glu         
240                 245                 250                 255         

ggg atc aca ggg cct cct gca gac tct tcg aaa ccc ata ggg cca gat     1237
Gly Ile Thr Gly Pro Pro Ala Asp Ser Ser Lys Pro Ile Gly Pro Asp         
                260                 265                 270             

gat gct ata gac gcc ttg tca tct gac ttc acc tgt ggg tcg cct aca     1285
Asp Ala Ile Asp Ala Leu Ser Ser Asp Phe Thr Cys Gly Ser Pro Thr         
            275                 280                 285                 

gct gct gga aag aaa act gaa aaa gag gaa tct aca gaa gtt tta aaa     1333
Ala Ala Gly Lys Lys Thr Glu Lys Glu Glu Ser Thr Glu Val Leu Lys         
        290                 295                 300                     

gct cag tca gca ggg aca gtc aga agt gct gct cca ccc caa gag aag     1381
Ala Gln Ser Ala Gly Thr Val Arg Ser Ala Ala Pro Pro Gln Glu Lys         
    305                 310                 315                         

aaa aga aag gtg gag aag gat aca atg agt gat caa gca ctc gag gct     1429
Lys Arg Lys Val Glu Lys Asp Thr Met Ser Asp Gln Ala Leu Glu Ala         
320                 325                 330                 335         

ctg tcg gct tca ctg ggc acc cgg caa gca gaa cct gag ctc gac ctc     1477
Leu Ser Ala Ser Leu Gly Thr Arg Gln Ala Glu Pro Glu Leu Asp Leu         
                340                 345                 350             

cgc tca att aag gaa gtc gat gag gca aaa gct aaa gaa gaa aaa cta     1525
Arg Ser Ile Lys Glu Val Asp Glu Ala Lys Ala Lys Glu Glu Lys Leu         
            355                 360                 365                 

gag aag tgt ggt gag gat gat gaa aca atc cca tct gag tac aga tta     1573
Glu Lys Cys Gly Glu Asp Asp Glu Thr Ile Pro Ser Glu Tyr Arg Leu         
        370                 375                 380                     

aaa cca gcc acg gat aaa gat gga aaa cca cta ttg cca gag cct gaa     1621
Lys Pro Ala Thr Asp Lys Asp Gly Lys Pro Leu Leu Pro Glu Pro Glu         
    385                 390                 395                         

gaa aaa ccc aag cct cgg agt gaa tca gaa ctc att gat gaa ctt tca     1669
Glu Lys Pro Lys Pro Arg Ser Glu Ser Glu Leu Ile Asp Glu Leu Ser         
400                 405                 410                 415         

gaa gat ttt gac cgg tct gaa tgt aaa gag aaa cca tct aag cca act     1717
Glu Asp Phe Asp Arg Ser Glu Cys Lys Glu Lys Pro Ser Lys Pro Thr         
                420                 425                 430             

gaa aag aca gaa gaa tct aag gcc gct gct cca gct cct gtg tcg gag     1765
Glu Lys Thr Glu Glu Ser Lys Ala Ala Ala Pro Ala Pro Val Ser Glu         
            435                 440                 445                 

gct gtg tgt cgg acc tcc atg tgt agt ata cag tca gca ccc cct gag     1813
Ala Val Cys Arg Thr Ser Met Cys Ser Ile Gln Ser Ala Pro Pro Glu         
        450                 455                 460                     

ccg gct acc ttg aag ggc aca gtg cca gat gat gct gta gaa gcc ttg     1861
Pro Ala Thr Leu Lys Gly Thr Val Pro Asp Asp Ala Val Glu Ala Leu         
    465                 470                 475                         

gct gat agc ctg ggg aaa aag gaa gca gat cca gaa gat gga aaa cct     1909
Ala Asp Ser Leu Gly Lys Lys Glu Ala Asp Pro Glu Asp Gly Lys Pro         
480                 485                 490                 495         

gtg atg gat aaa gtc aag gag aag gcc aaa gaa gaa gac cgt gaa aag     1957
Val Met Asp Lys Val Lys Glu Lys Ala Lys Glu Glu Asp Arg Glu Lys         
                500                 505                 510             

ctt ggt gaa aaa gaa gaa aca att cct cct gat tat aga tta gaa gag     2005
Leu Gly Glu Lys Glu Glu Thr Ile Pro Pro Asp Tyr Arg Leu Glu Glu         
            515                 520                 525                 

gtc aag gat aaa gat gga aag cca ctc ctg cca aaa gag tct aag gaa     2053
Val Lys Asp Lys Asp Gly Lys Pro Leu Leu Pro Lys Glu Ser Lys Glu         
        530                 535                 540                     

cag ctt cca ccc atg agt gaa gac ttc ctt ctg gat gct ttg tct gag     2101
Gln Leu Pro Pro Met Ser Glu Asp Phe Leu Leu Asp Ala Leu Ser Glu         
    545                 550                 555                         

gac ttc tct ggt cca caa aat gct tca tct ctt aaa ttt gaa gat gct     2149
Asp Phe Ser Gly Pro Gln Asn Ala Ser Ser Leu Lys Phe Glu Asp Ala         
560                 565                 570                 575         

aaa ctt gct gct gcc atc tct gaa gtg gtt tcc caa acc cca gct tca     2197
Lys Leu Ala Ala Ala Ile Ser Glu Val Val Ser Gln Thr Pro Ala Ser         
                580                 585                 590             

acg acc caa gct gga gcc cca ccc cgt gat acc tcg cag agt gac aaa     2245
Thr Thr Gln Ala Gly Ala Pro Pro Arg Asp Thr Ser Gln Ser Asp Lys         
            595                 600                 605                 

gac ctc gat gat gcc ttg gat aaa ctc tct gac agt cta gga caa agg     2293
Asp Leu Asp Asp Ala Leu Asp Lys Leu Ser Asp Ser Leu Gly Gln Arg         
        610                 615                 620                     

cag cct gac cca gat gag aac aaa cca atg gaa gat aaa gta aag gaa     2341
Gln Pro Asp Pro Asp Glu Asn Lys Pro Met Glu Asp Lys Val Lys Glu         
    625                 630                 635                         

aaa gct aaa gct gaa cat aga gac aag ctt gga gaa aga gat gac act     2389
Lys Ala Lys Ala Glu His Arg Asp Lys Leu Gly Glu Arg Asp Asp Thr         
640                 645                 650                 655         

atc cca cct gaa tac aga cat ctc ctg gat gat aat gga cag gac aaa     2437
Ile Pro Pro Glu Tyr Arg His Leu Leu Asp Asp Asn Gly Gln Asp Lys         
                660                 665                 670             

cca gtg aag cca cct aca aag aaa tca gag gat tca aag aaa cct gca     2485
Pro Val Lys Pro Pro Thr Lys Lys Ser Glu Asp Ser Lys Lys Pro Ala         
            675                 680                 685                 

gat gac caa gac ccc att gat gct ctc tca gga gat ctg gac agc tgt     2533
Asp Asp Gln Asp Pro Ile Asp Ala Leu Ser Gly Asp Leu Asp Ser Cys         
        690                 695                 700                     

ccc tcc act aca gaa acc tca cag aac aca gca aag gat aag tgc aag     2581
Pro Ser Thr Thr Glu Thr Ser Gln Asn Thr Ala Lys Asp Lys Cys Lys         
    705                 710                 715                         

aag gct gct tcc agc tcc aaa gca cct aag aat gga ggt aaa gcg aag     2629
Lys Ala Ala Ser Ser Ser Lys Ala Pro Lys Asn Gly Gly Lys Ala Lys         
720                 725                 730                 735         

gat tca gca aag aca aca gag gaa act tcc aag cca aaa gat gac taa     2677
Asp Ser Ala Lys Thr Thr Glu Glu Thr Ser Lys Pro Lys Asp Asp             
                740                 745                 750             

agaaatacaa gttaaggtat ctggtatctg catgtaaaat cttcagctgg tggatggtga   2737

cttttgaaga acaaaaggct ttggcaacag aaaacaattg ttctgggtga tttctagaat   2797

ggtttttgtt gagtctctga acatcctaaa tattggtttg ttattctttt ccagaaagaa   2857

aatgaatttg actggttcac ctgtgtactg agtattgata aactttgaat ttttttaatt   2917

gccttcaatt gggagagaaa gctttatatt tgtgtgagga cttctgcatc ttacagtcag   2977

cacagaacac actgagactt gaatcaagtc agcaacagag caaaataaag gttagataag   3037

tccttgtgta gcaaatttcg agcataagaa ataaaatcta attaattctt agggtactca   3097

tctgacttga actctgttgg tttactgtgt tagtaaactg tgctttctat tatctataca   3157

taaaacctga gcagcaactg tgtctttaga gctattgcca cattagcctt tgcactgtat   3217

agcgtctggc tttatggaac ttaagtttac caaatataaa aagaaacttc tgcttttaaa   3277

aaaattatat atatatatta aatttgaaac ctgcatttct cccacagcaa tgtaagaagt   3337

aggctctgat gtcctaccac tttgaatggt tttctaatat cttaatgaat agttcctgaa   3397

cattgcactg atatcatcga ttagaatttt gatatttaat ttcatcttta tttcctggta   3457

gagaatgcac gacaagatgt caggtacata acataaaaca gattgggaat ttattgtttc   3517

caaagggcat gcccttcctt agca                                          3541


<210>  78
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ser Gln Pro Gly Gln Lys Pro Ala Ala Ser Pro Arg Pro Arg Arg 
1               5                   10                  15      


Ala Ala Ala Ala Arg Arg Thr His Glu His Val Ser Glu Lys Thr Ser 
            20                  25                  30          


Glu Ser Pro Ser Lys Pro Gly Glu Lys Lys Gly Ser Asp Glu Lys Lys 
        35                  40                  45              


Ala Ala Ser Leu Gly Ser Ser Gln Ser Ser Arg Thr Tyr Ala Gly Gly 
    50                  55                  60                  


Thr Ala Ser Ala Thr Lys Val Ser Ala Ser Ser Gly Ala Thr Ser Lys 
65                  70                  75                  80  


Ser Ser Ser Met Asn Pro Thr Glu Thr Lys Ala Val Lys Thr Glu Pro 
                85                  90                  95      


Glu Lys Lys Ser Gln Ser Thr Lys Pro Lys Ser Leu Pro Lys Gln Ala 
            100                 105                 110         


Ser Asp Thr Gly Ser Asn Asp Ala His Asn Lys Lys Ala Val Ser Arg 
        115                 120                 125             


Ser Ala Glu Gln Gln Pro Ser Glu Lys Ser Thr Glu Pro Lys Thr Lys 
    130                 135                 140                 


Pro Gln Asp Met Ile Ser Ala Gly Gly Glu Ser Val Ala Gly Ile Thr 
145                 150                 155                 160 


Ala Ile Ser Gly Lys Pro Gly Asp Lys Lys Lys Glu Lys Lys Ser Leu 
                165                 170                 175     


Thr Pro Ala Val Pro Val Glu Ser Lys Pro Asp Lys Pro Ser Gly Lys 
            180                 185                 190         


Ser Gly Met Asp Ala Ala Leu Asp Asp Leu Ile Asp Thr Leu Gly Gly 
        195                 200                 205             


Pro Glu Glu Thr Glu Glu Glu Asn Thr Thr Tyr Thr Gly Pro Glu Val 
    210                 215                 220                 


Ser Asp Pro Met Ser Ser Thr Tyr Ile Glu Glu Leu Gly Lys Arg Glu 
225                 230                 235                 240 


Val Thr Ile Pro Pro Lys Tyr Arg Glu Leu Leu Ala Lys Lys Glu Gly 
                245                 250                 255     


Ile Thr Gly Pro Pro Ala Asp Ser Ser Lys Pro Ile Gly Pro Asp Asp 
            260                 265                 270         


Ala Ile Asp Ala Leu Ser Ser Asp Phe Thr Cys Gly Ser Pro Thr Ala 
        275                 280                 285             


Ala Gly Lys Lys Thr Glu Lys Glu Glu Ser Thr Glu Val Leu Lys Ala 
    290                 295                 300                 


Gln Ser Ala Gly Thr Val Arg Ser Ala Ala Pro Pro Gln Glu Lys Lys 
305                 310                 315                 320 


Arg Lys Val Glu Lys Asp Thr Met Ser Asp Gln Ala Leu Glu Ala Leu 
                325                 330                 335     


Ser Ala Ser Leu Gly Thr Arg Gln Ala Glu Pro Glu Leu Asp Leu Arg 
            340                 345                 350         


Ser Ile Lys Glu Val Asp Glu Ala Lys Ala Lys Glu Glu Lys Leu Glu 
        355                 360                 365             


Lys Cys Gly Glu Asp Asp Glu Thr Ile Pro Ser Glu Tyr Arg Leu Lys 
    370                 375                 380                 


Pro Ala Thr Asp Lys Asp Gly Lys Pro Leu Leu Pro Glu Pro Glu Glu 
385                 390                 395                 400 


Lys Pro Lys Pro Arg Ser Glu Ser Glu Leu Ile Asp Glu Leu Ser Glu 
                405                 410                 415     


Asp Phe Asp Arg Ser Glu Cys Lys Glu Lys Pro Ser Lys Pro Thr Glu 
            420                 425                 430         


Lys Thr Glu Glu Ser Lys Ala Ala Ala Pro Ala Pro Val Ser Glu Ala 
        435                 440                 445             


Val Cys Arg Thr Ser Met Cys Ser Ile Gln Ser Ala Pro Pro Glu Pro 
    450                 455                 460                 


Ala Thr Leu Lys Gly Thr Val Pro Asp Asp Ala Val Glu Ala Leu Ala 
465                 470                 475                 480 


Asp Ser Leu Gly Lys Lys Glu Ala Asp Pro Glu Asp Gly Lys Pro Val 
                485                 490                 495     


Met Asp Lys Val Lys Glu Lys Ala Lys Glu Glu Asp Arg Glu Lys Leu 
            500                 505                 510         


Gly Glu Lys Glu Glu Thr Ile Pro Pro Asp Tyr Arg Leu Glu Glu Val 
        515                 520                 525             


Lys Asp Lys Asp Gly Lys Pro Leu Leu Pro Lys Glu Ser Lys Glu Gln 
    530                 535                 540                 


Leu Pro Pro Met Ser Glu Asp Phe Leu Leu Asp Ala Leu Ser Glu Asp 
545                 550                 555                 560 


Phe Ser Gly Pro Gln Asn Ala Ser Ser Leu Lys Phe Glu Asp Ala Lys 
                565                 570                 575     


Leu Ala Ala Ala Ile Ser Glu Val Val Ser Gln Thr Pro Ala Ser Thr 
            580                 585                 590         


Thr Gln Ala Gly Ala Pro Pro Arg Asp Thr Ser Gln Ser Asp Lys Asp 
        595                 600                 605             


Leu Asp Asp Ala Leu Asp Lys Leu Ser Asp Ser Leu Gly Gln Arg Gln 
    610                 615                 620                 


Pro Asp Pro Asp Glu Asn Lys Pro Met Glu Asp Lys Val Lys Glu Lys 
625                 630                 635                 640 


Ala Lys Ala Glu His Arg Asp Lys Leu Gly Glu Arg Asp Asp Thr Ile 
                645                 650                 655     


Pro Pro Glu Tyr Arg His Leu Leu Asp Asp Asn Gly Gln Asp Lys Pro 
            660                 665                 670         


Val Lys Pro Pro Thr Lys Lys Ser Glu Asp Ser Lys Lys Pro Ala Asp 
        675                 680                 685             


Asp Gln Asp Pro Ile Asp Ala Leu Ser Gly Asp Leu Asp Ser Cys Pro 
    690                 695                 700                 


Ser Thr Thr Glu Thr Ser Gln Asn Thr Ala Lys Asp Lys Cys Lys Lys 
705                 710                 715                 720 


Ala Ala Ser Ser Ser Lys Ala Pro Lys Asn Gly Gly Lys Ala Lys Asp 
                725                 730                 735     


Ser Ala Lys Thr Thr Glu Glu Thr Ser Lys Pro Lys Asp Asp 
            740                 745                 750 


<210>  79
<211>  9058
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (44)..(7699)
<223>  

<400>  79
agtgtaattt gagaccggtg gtaaggattg gagcgagcta gag atg ctg cac gct       55
                                                Met Leu His Ala         
                                                1                       

gct aac aag gga agg aag cct tca gct gag gca ggt cgt ccc att cca      103
Ala Asn Lys Gly Arg Lys Pro Ser Ala Glu Ala Gly Arg Pro Ile Pro         
5                   10                  15                  20          

cct aca tcc tcg cct agt ctc ctc cca tct gct cag ctg cct agc tcc      151
Pro Thr Ser Ser Pro Ser Leu Leu Pro Ser Ala Gln Leu Pro Ser Ser         
                25                  30                  35              

cat aat cct cca cca gtt agc tgc cag atg cca ttg cta gac agc aac      199
His Asn Pro Pro Pro Val Ser Cys Gln Met Pro Leu Leu Asp Ser Asn         
            40                  45                  50                  

acc tcc cat caa atc atg gac acc aac cct gat gag gaa ttc tcc ccc      247
Thr Ser His Gln Ile Met Asp Thr Asn Pro Asp Glu Glu Phe Ser Pro         
        55                  60                  65                      

aat tca tac ctg ctc aga gca tgc tca ggg ccc cag caa gcc tcc agc      295
Asn Ser Tyr Leu Leu Arg Ala Cys Ser Gly Pro Gln Gln Ala Ser Ser         
    70                  75                  80                          

agt ggc cct ccg aac cac cac agc cag tcg act ctg agg ccc cct ctc      343
Ser Gly Pro Pro Asn His His Ser Gln Ser Thr Leu Arg Pro Pro Leu         
85                  90                  95                  100         

cca ccc cct cac aac cac acg ctg tcc cat cac cac tcg tcc gcc aac      391
Pro Pro Pro His Asn His Thr Leu Ser His His His Ser Ser Ala Asn         
                105                 110                 115             

tcc ctc aac agg aac tca ctg acc aat cgg cgg agt cag atc cac gcc      439
Ser Leu Asn Arg Asn Ser Leu Thr Asn Arg Arg Ser Gln Ile His Ala         
            120                 125                 130                 

ccg gcc cca gcg ccc aat gac ctg gcc acc aca cca gag tcc gtt cag      487
Pro Ala Pro Ala Pro Asn Asp Leu Ala Thr Thr Pro Glu Ser Val Gln         
        135                 140                 145                     

ctt cag gac agc tgg gtg cta aac agc aac gtg cca ctg gag acc cgg      535
Leu Gln Asp Ser Trp Val Leu Asn Ser Asn Val Pro Leu Glu Thr Arg         
    150                 155                 160                         

cac ttc ctc ttc aag acc tcc tcg ggg agc aca ccc ttg ttc agc agc      583
His Phe Leu Phe Lys Thr Ser Ser Gly Ser Thr Pro Leu Phe Ser Ser         
165                 170                 175                 180         

tct tcc ccg gga tac cct ttg acc tca gga acg gtt tac acg ccc ccg      631
Ser Ser Pro Gly Tyr Pro Leu Thr Ser Gly Thr Val Tyr Thr Pro Pro         
                185                 190                 195             

ccc cgc ctg ctg ccc agg aat act ttc tcc agg aag gct ttc aag ctg      679
Pro Arg Leu Leu Pro Arg Asn Thr Phe Ser Arg Lys Ala Phe Lys Leu         
            200                 205                 210                 

aag aag ccc tcc aaa tac tgc agc tgg aaa tgt gct gcc ctc tcc gcc      727
Lys Lys Pro Ser Lys Tyr Cys Ser Trp Lys Cys Ala Ala Leu Ser Ala         
        215                 220                 225                     

att gcc gcg gcc ctc ctc ttg gct att ttg ctg gcg tat ttc ata gca      775
Ile Ala Ala Ala Leu Leu Leu Ala Ile Leu Leu Ala Tyr Phe Ile Ala         
    230                 235                 240                         

atg cat ctg ctc gga ctc aat tgg caa ctc cag cct gca gat ggg cac      823
Met His Leu Leu Gly Leu Asn Trp Gln Leu Gln Pro Ala Asp Gly His         
245                 250                 255                 260         

acc ttt aac aat ggg ata agg acc ggc tta cca gga aac gat gat gtg      871
Thr Phe Asn Asn Gly Ile Arg Thr Gly Leu Pro Gly Asn Asp Asp Val         
                265                 270                 275             

gca aca atg cca tct gga ggc aaa gtg ccc tgg tcg ttg aaa aac agc      919
Ala Thr Met Pro Ser Gly Gly Lys Val Pro Trp Ser Leu Lys Asn Ser         
            280                 285                 290                 

agc ata gac agt ggt gaa gca gaa gtt ggt cgg cgg gta aca caa gaa      967
Ser Ile Asp Ser Gly Glu Ala Glu Val Gly Arg Arg Val Thr Gln Glu         
        295                 300                 305                     

gtc cca cca ggg gtg ttt tgg agg tca caa att cac atc agt cag ccc     1015
Val Pro Pro Gly Val Phe Trp Arg Ser Gln Ile His Ile Ser Gln Pro         
    310                 315                 320                         

cag ttc tta aag ttc aac atc tcc ctc ggg aag gac gct ctc ttt ggt     1063
Gln Phe Leu Lys Phe Asn Ile Ser Leu Gly Lys Asp Ala Leu Phe Gly         
325                 330                 335                 340         

gtt tac ata aga aga gga ctt cca cca tct cat gcc cag tat gac ttc     1111
Val Tyr Ile Arg Arg Gly Leu Pro Pro Ser His Ala Gln Tyr Asp Phe         
                345                 350                 355             

atg gaa cgt ctg gac ggg aag gag aag tgg agt gtg gtt gag tct ccc     1159
Met Glu Arg Leu Asp Gly Lys Glu Lys Trp Ser Val Val Glu Ser Pro         
            360                 365                 370                 

agg gaa cgc cgg agc ata cag acc ttg gtt cag aat gaa gcc gtg ttt     1207
Arg Glu Arg Arg Ser Ile Gln Thr Leu Val Gln Asn Glu Ala Val Phe         
        375                 380                 385                     

gtg cag tac ctg gat gtg ggc ctg tgg cat ctg gcc ttc tac aat gat     1255
Val Gln Tyr Leu Asp Val Gly Leu Trp His Leu Ala Phe Tyr Asn Asp         
    390                 395                 400                         

gga aaa gac aaa gag atg gtt tcc ttc aat act gtt gtc cta gat tca     1303
Gly Lys Asp Lys Glu Met Val Ser Phe Asn Thr Val Val Leu Asp Ser         
405                 410                 415                 420         

gtg cag gac tgt cca cgt aac tgc cat ggg aat ggt gaa tgt gtg tcc     1351
Val Gln Asp Cys Pro Arg Asn Cys His Gly Asn Gly Glu Cys Val Ser         
                425                 430                 435             

ggg gtg tgt cac tgt ttc cca gga ttt cta gga gca gac tgt gct aaa     1399
Gly Val Cys His Cys Phe Pro Gly Phe Leu Gly Ala Asp Cys Ala Lys         
            440                 445                 450                 

gct gcc tgc cct gtc ctg tgc agt ggg aat gga caa tat tct aaa ggg     1447
Ala Ala Cys Pro Val Leu Cys Ser Gly Asn Gly Gln Tyr Ser Lys Gly         
        455                 460                 465                     

acg tgc cag tgc tac agc ggc tgg aaa ggt gca gag tgc gac gtg ccc     1495
Thr Cys Gln Cys Tyr Ser Gly Trp Lys Gly Ala Glu Cys Asp Val Pro         
    470                 475                 480                         

atg aat cag tgc atc gat cct tcc tgc ggg ggc cac ggc tcc tgc att     1543
Met Asn Gln Cys Ile Asp Pro Ser Cys Gly Gly His Gly Ser Cys Ile         
485                 490                 495                 500         

gat ggg aac tgt gtc tgc tct gct ggc tac aaa ggc gag cac tgt gag     1591
Asp Gly Asn Cys Val Cys Ser Ala Gly Tyr Lys Gly Glu His Cys Glu         
                505                 510                 515             

gaa gtt gat tgc ttg gat ccc acc tgc tcc agc cac gga gtc tgt gtg     1639
Glu Val Asp Cys Leu Asp Pro Thr Cys Ser Ser His Gly Val Cys Val         
            520                 525                 530                 

aat gga gaa tgc ctg tgc agc cct ggc tgg ggt ggt ctg aac tgt gag     1687
Asn Gly Glu Cys Leu Cys Ser Pro Gly Trp Gly Gly Leu Asn Cys Glu         
        535                 540                 545                     

ctg gcg agg gtc cag tgc cca gac cag tgc agt ggg cat ggc acg tac     1735
Leu Ala Arg Val Gln Cys Pro Asp Gln Cys Ser Gly His Gly Thr Tyr         
    550                 555                 560                         

ctg cct gac acg ggc ctc tgc agc tgc gat ccc aac tgg atg ggt ccc     1783
Leu Pro Asp Thr Gly Leu Cys Ser Cys Asp Pro Asn Trp Met Gly Pro         
565                 570                 575                 580         

gac tgc tct gtt gat ggc tgc cct gac ttg tgc aac ggt aac ggg aga     1831
Asp Cys Ser Val Asp Gly Cys Pro Asp Leu Cys Asn Gly Asn Gly Arg         
                585                 590                 595             

tgc aca ctg ggt cag aac agc tgg cag tgt gtc tgc cag acc ggc tgg     1879
Cys Thr Leu Gly Gln Asn Ser Trp Gln Cys Val Cys Gln Thr Gly Trp         
            600                 605                 610                 

aga ggg ccc gga tgc aac gtt gcc atg gaa act tcc tgt gct gat aac     1927
Arg Gly Pro Gly Cys Asn Val Ala Met Glu Thr Ser Cys Ala Asp Asn         
        615                 620                 625                     

aag gat aat gag gga gat ggc ctg gtg gat tgt ttg gac cct gac tgc     1975
Lys Asp Asn Glu Gly Asp Gly Leu Val Asp Cys Leu Asp Pro Asp Cys         
    630                 635                 640                         

tgc ctg cag tca gcc tgt cag aac agc ctg ctc tgc cgg ggg tcc cgg     2023
Cys Leu Gln Ser Ala Cys Gln Asn Ser Leu Leu Cys Arg Gly Ser Arg         
645                 650                 655                 660         

gac cca ctg gac atc att cag cag ggc cag acg gat tgg ccc gca gtg     2071
Asp Pro Leu Asp Ile Ile Gln Gln Gly Gln Thr Asp Trp Pro Ala Val         
                665                 670                 675             

aag tcc ttc tat gac cgt atc aag ctc ttg gca ggc aag gat agc acc     2119
Lys Ser Phe Tyr Asp Arg Ile Lys Leu Leu Ala Gly Lys Asp Ser Thr         
            680                 685                 690                 

cac atc att cct gga gag aac cct ttc aac agc agc ttg gtt tct ctc     2167
His Ile Ile Pro Gly Glu Asn Pro Phe Asn Ser Ser Leu Val Ser Leu         
        695                 700                 705                     

atc cga ggc caa gta gta act aca gat gga act ccc ctg gtc ggt gtg     2215
Ile Arg Gly Gln Val Val Thr Thr Asp Gly Thr Pro Leu Val Gly Val         
    710                 715                 720                         

aac gtg tct ttt gtc aag tac cca aaa tac ggc tac acc atc acc cgc     2263
Asn Val Ser Phe Val Lys Tyr Pro Lys Tyr Gly Tyr Thr Ile Thr Arg         
725                 730                 735                 740         

cag gat ggc acg ttc gac ctg atc gca aat gga ggt gct tcc ttg act     2311
Gln Asp Gly Thr Phe Asp Leu Ile Ala Asn Gly Gly Ala Ser Leu Thr         
                745                 750                 755             

cta cac ttt gag cga gcc ccg ttc atg agc cag gag cgc act gtg tgg     2359
Leu His Phe Glu Arg Ala Pro Phe Met Ser Gln Glu Arg Thr Val Trp         
            760                 765                 770                 

ctg ccg tgg aac agc ttt tac gcc atg gac acc ctg gtg atg aag acc     2407
Leu Pro Trp Asn Ser Phe Tyr Ala Met Asp Thr Leu Val Met Lys Thr         
        775                 780                 785                     

gag gag aac tcc atc ccc agc tgt gac ctc agt ggc ttt gtc cgg cct     2455
Glu Glu Asn Ser Ile Pro Ser Cys Asp Leu Ser Gly Phe Val Arg Pro         
    790                 795                 800                         

gat cca atc atc atc tcc tcc cca ctg tcc acc ttc ttt agt gct gcc     2503
Asp Pro Ile Ile Ile Ser Ser Pro Leu Ser Thr Phe Phe Ser Ala Ala         
805                 810                 815                 820         

cct ggg cag aat ccc atc gtg cct gag acc cag gtt ctt cat gaa gaa     2551
Pro Gly Gln Asn Pro Ile Val Pro Glu Thr Gln Val Leu His Glu Glu         
                825                 830                 835             

atc gag ctc cct ggt tcc aat gtg aaa ctt cgc tat ctg agc tct aga     2599
Ile Glu Leu Pro Gly Ser Asn Val Lys Leu Arg Tyr Leu Ser Ser Arg         
            840                 845                 850                 

act gca ggg tac aag tca ctg ctg aag atc acc atg acc cag tcc aca     2647
Thr Ala Gly Tyr Lys Ser Leu Leu Lys Ile Thr Met Thr Gln Ser Thr         
        855                 860                 865                     

gtg ccc ctg aac ctc att agg gtt cac ctg atg gtg gct gtc gag ggg     2695
Val Pro Leu Asn Leu Ile Arg Val His Leu Met Val Ala Val Glu Gly         
    870                 875                 880                         

cat ctc ttc cag aag tca ttc cag gct tct ccc aac ctg gcc tac acc     2743
His Leu Phe Gln Lys Ser Phe Gln Ala Ser Pro Asn Leu Ala Tyr Thr         
885                 890                 895                 900         

ttc atc tgg gac aag aca gat gcg tat ggc caa agg gtg tat gga ctc     2791
Phe Ile Trp Asp Lys Thr Asp Ala Tyr Gly Gln Arg Val Tyr Gly Leu         
                905                 910                 915             

tca gat gct gtt gtg tct gtc ggg ttt gaa tat gag acc tgt ccc agt     2839
Ser Asp Ala Val Val Ser Val Gly Phe Glu Tyr Glu Thr Cys Pro Ser         
            920                 925                 930                 

cta att ctc tgg gag aaa agg aca gcc ctc ctt cag gga ttc gag ctg     2887
Leu Ile Leu Trp Glu Lys Arg Thr Ala Leu Leu Gln Gly Phe Glu Leu         
        935                 940                 945                     

gac ccc tcc aac ctc ggt ggc tgg tcc cta gac aaa cac cac atc ctc     2935
Asp Pro Ser Asn Leu Gly Gly Trp Ser Leu Asp Lys His His Ile Leu         
    950                 955                 960                         

aat gtt aaa agt gga atc cta cac aaa ggc act ggg gaa aac cag ttc     2983
Asn Val Lys Ser Gly Ile Leu His Lys Gly Thr Gly Glu Asn Gln Phe         
965                 970                 975                 980         

ctg acc cag cag cct gcc atc atc acc agc atc atg ggc aat ggt cgc     3031
Leu Thr Gln Gln Pro Ala Ile Ile Thr Ser Ile Met Gly Asn Gly Arg         
                985                 990                 995             

cgc cgg agc att  tcc tgt ccc agc tgc  aac ggc ctt gct gaa  ggc      3076
Arg Arg Ser Ile  Ser Cys Pro Ser Cys  Asn Gly Leu Ala Glu  Gly          
            1000                 1005                 1010              

aac aag ctg ctg  gcc cca gtg gct ctg  gct gtt gga atc gat  ggg      3121
Asn Lys Leu Leu  Ala Pro Val Ala Leu  Ala Val Gly Ile Asp  Gly          
            1015                 1020                 1025              

agc ctc tat gtg  ggt gac ttc aat tac  atc cga cgc atc ttt  ccc      3166
Ser Leu Tyr Val  Gly Asp Phe Asn Tyr  Ile Arg Arg Ile Phe  Pro          
            1030                 1035                 1040              

tct cga aat gtg  acc agc atc ttg gag  tta cga aat aaa gag  ttt      3211
Ser Arg Asn Val  Thr Ser Ile Leu Glu  Leu Arg Asn Lys Glu  Phe          
            1045                 1050                 1055              

aaa cat agc aac  aac cca gca cac aag  tac tac ttg gca gtg  gac      3256
Lys His Ser Asn  Asn Pro Ala His Lys  Tyr Tyr Leu Ala Val  Asp          
            1060                 1065                 1070              

ccc gtg tcc ggc  tcg ctc tac gtg tcc  gac acc aac agc agg  aga      3301
Pro Val Ser Gly  Ser Leu Tyr Val Ser  Asp Thr Asn Ser Arg  Arg          
            1075                 1080                 1085              

atc tac cgc gtc  aag tct ctg agt gga  acc aaa gac ctg gct  ggg      3346
Ile Tyr Arg Val  Lys Ser Leu Ser Gly  Thr Lys Asp Leu Ala  Gly          
            1090                 1095                 1100              

aat tcg gaa gtt  gtg gca ggg acg gga  gag cag tgt cta ccc  ttt      3391
Asn Ser Glu Val  Val Ala Gly Thr Gly  Glu Gln Cys Leu Pro  Phe          
            1105                 1110                 1115              

gat gaa gcc cgc  tgc ggg gat gga ggg  aag gcc ata gat gca  acc      3436
Asp Glu Ala Arg  Cys Gly Asp Gly Gly  Lys Ala Ile Asp Ala  Thr          
            1120                 1125                 1130              

ctg atg agc ccg  aga ggt att gca gta  gac aag aat ggg ctc  atg      3481
Leu Met Ser Pro  Arg Gly Ile Ala Val  Asp Lys Asn Gly Leu  Met          
            1135                 1140                 1145              

tac ttt gtc gat  gcc acc atg atc cgg  aag gtt gac cag aat  gga      3526
Tyr Phe Val Asp  Ala Thr Met Ile Arg  Lys Val Asp Gln Asn  Gly          
            1150                 1155                 1160              

atc atc tcc acc  ctg ctg ggc tcc aat  gac ctc act gcc gtc  cgg      3571
Ile Ile Ser Thr  Leu Leu Gly Ser Asn  Asp Leu Thr Ala Val  Arg          
            1165                 1170                 1175              

ccg ctg agc tgt  gat tcc agc atg gat  gta gcc cag gtt cgt  ctg      3616
Pro Leu Ser Cys  Asp Ser Ser Met Asp  Val Ala Gln Val Arg  Leu          
            1180                 1185                 1190              

gag tgg cca aca  gac ctt gct gtc aat  ccc atg gat aac tcc  ttg      3661
Glu Trp Pro Thr  Asp Leu Ala Val Asn  Pro Met Asp Asn Ser  Leu          
            1195                 1200                 1205              

tat gtt cta gag  aac aat gtc atc ctt  cga atc acc gag aac  cac      3706
Tyr Val Leu Glu  Asn Asn Val Ile Leu  Arg Ile Thr Glu Asn  His          
            1210                 1215                 1220              

caa gtc agc atc  att gcg gga cgc ccc  atg cac tgc caa gtt  cct      3751
Gln Val Ser Ile  Ile Ala Gly Arg Pro  Met His Cys Gln Val  Pro          
            1225                 1230                 1235              

ggc att gac tac  tca ctc agc aaa cta  gcc att cac tct gcc  ctg      3796
Gly Ile Asp Tyr  Ser Leu Ser Lys Leu  Ala Ile His Ser Ala  Leu          
            1240                 1245                 1250              

gag tca gcc agt  gcc att gcc att tct  cac act ggg gtc ctc  tac      3841
Glu Ser Ala Ser  Ala Ile Ala Ile Ser  His Thr Gly Val Leu  Tyr          
            1255                 1260                 1265              

atc act gag aca  gat gag aag aag att  aac cgt cta cgc cag  gta      3886
Ile Thr Glu Thr  Asp Glu Lys Lys Ile  Asn Arg Leu Arg Gln  Val          
            1270                 1275                 1280              

aca acc aac ggg  gag atc tgc ctt tta  gct ggg gca gcc tcg  gac      3931
Thr Thr Asn Gly  Glu Ile Cys Leu Leu  Ala Gly Ala Ala Ser  Asp          
            1285                 1290                 1295              

tgc gac tgc aaa  aac gat gtc aat tgc  aac tgc tat tca gga  gat      3976
Cys Asp Cys Lys  Asn Asp Val Asn Cys  Asn Cys Tyr Ser Gly  Asp          
            1300                 1305                 1310              

gat gcc tac gcg  act gat gcc atc ttg  aat tcc cca tca tcc  tta      4021
Asp Ala Tyr Ala  Thr Asp Ala Ile Leu  Asn Ser Pro Ser Ser  Leu          
            1315                 1320                 1325              

gct gta gct cca  gat ggt acc att tac  att gca gac ctt gga  aat      4066
Ala Val Ala Pro  Asp Gly Thr Ile Tyr  Ile Ala Asp Leu Gly  Asn          
            1330                 1335                 1340              

att cgg atc agg  gcg gtc agc aag aac  aag cct gtt ctt aat  gcc      4111
Ile Arg Ile Arg  Ala Val Ser Lys Asn  Lys Pro Val Leu Asn  Ala          
            1345                 1350                 1355              

ttc aac cag tat  gag gct gca tcc ccc  gga gag cag gag tta  tat      4156
Phe Asn Gln Tyr  Glu Ala Ala Ser Pro  Gly Glu Gln Glu Leu  Tyr          
            1360                 1365                 1370              

gtt ttc aac gct  gat ggc atc cac caa  tac act gtg agc ctg  gtg      4201
Val Phe Asn Ala  Asp Gly Ile His Gln  Tyr Thr Val Ser Leu  Val          
            1375                 1380                 1385              

aca ggg gag tac  ttg tac aat ttc aca  tat agt act gac aat  gat      4246
Thr Gly Glu Tyr  Leu Tyr Asn Phe Thr  Tyr Ser Thr Asp Asn  Asp          
            1390                 1395                 1400              

gtc act gaa ttg  att gac aat aat ggg  aat tcc ctg aag atc  cgt      4291
Val Thr Glu Leu  Ile Asp Asn Asn Gly  Asn Ser Leu Lys Ile  Arg          
            1405                 1410                 1415              

cgg gac agc agt  ggc atg ccc cgt cac  ctg ctc atg cct gac  aac      4336
Arg Asp Ser Ser  Gly Met Pro Arg His  Leu Leu Met Pro Asp  Asn          
            1420                 1425                 1430              

cag atc atc acc  ctc acc gtg ggc acc  aat gga ggc ctc aaa  gtc      4381
Gln Ile Ile Thr  Leu Thr Val Gly Thr  Asn Gly Gly Leu Lys  Val          
            1435                 1440                 1445              

gtg tcc aca cag  aac ctg gag ctt ggt  ctc atg acc tat gat  ggc      4426
Val Ser Thr Gln  Asn Leu Glu Leu Gly  Leu Met Thr Tyr Asp  Gly          
            1450                 1455                 1460              

aac act ggg ctc  ctg gcc acc aag agc  gat gaa aca gga tgg  acg      4471
Asn Thr Gly Leu  Leu Ala Thr Lys Ser  Asp Glu Thr Gly Trp  Thr          
            1465                 1470                 1475              

act ttc tat gac  tat gac cac gaa ggc  cgc ctg acc aac gtg  acg      4516
Thr Phe Tyr Asp  Tyr Asp His Glu Gly  Arg Leu Thr Asn Val  Thr          
            1480                 1485                 1490              

cgc ccc acg ggg  gtg gta acc agt ctg  cac cgg gaa atg gag  aaa      4561
Arg Pro Thr Gly  Val Val Thr Ser Leu  His Arg Glu Met Glu  Lys          
            1495                 1500                 1505              

tct att acc att  gac att gag aac tcc  aac cgt gat gat gac  gtc      4606
Ser Ile Thr Ile  Asp Ile Glu Asn Ser  Asn Arg Asp Asp Asp  Val          
            1510                 1515                 1520              

act gtc atc acc  aac ctc tct tca gta  gag gcc tcc tac aca  gtg      4651
Thr Val Ile Thr  Asn Leu Ser Ser Val  Glu Ala Ser Tyr Thr  Val          
            1525                 1530                 1535              

gta caa gat caa  gtt cgg aac agc tac  cag ctc tgt aat aat  ggt      4696
Val Gln Asp Gln  Val Arg Asn Ser Tyr  Gln Leu Cys Asn Asn  Gly          
            1540                 1545                 1550              

acc ctg agg gtg  atg tat gct aat ggg  atg ggt atc agc ttc  cac      4741
Thr Leu Arg Val  Met Tyr Ala Asn Gly  Met Gly Ile Ser Phe  His          
            1555                 1560                 1565              

agc gag ccc cat  gtc cta gcg ggc acc  atc acc ccc acc att  gga      4786
Ser Glu Pro His  Val Leu Ala Gly Thr  Ile Thr Pro Thr Ile  Gly          
            1570                 1575                 1580              

cgc tgc aac atc  tcc ctg cct atg gag  aat ggc tta aac tcc  att      4831
Arg Cys Asn Ile  Ser Leu Pro Met Glu  Asn Gly Leu Asn Ser  Ile          
            1585                 1590                 1595              

gag tgg cgc cta  aga aag gaa cag att  aaa ggc aaa gtc acc  atc      4876
Glu Trp Arg Leu  Arg Lys Glu Gln Ile  Lys Gly Lys Val Thr  Ile          
            1600                 1605                 1610              

ttt ggc agg aag  ctc cgg gtc cat gga  aga aat ctc ttg tcc  att      4921
Phe Gly Arg Lys  Leu Arg Val His Gly  Arg Asn Leu Leu Ser  Ile          
            1615                 1620                 1625              

gac tat gat cga  aat att cgg act gaa  aag atc tat gat gac  cac      4966
Asp Tyr Asp Arg  Asn Ile Arg Thr Glu  Lys Ile Tyr Asp Asp  His          
            1630                 1635                 1640              

cgg aag ttc acc  ctg agg atc att tat  gac cag gtg ggc cgc  ccc      5011
Arg Lys Phe Thr  Leu Arg Ile Ile Tyr  Asp Gln Val Gly Arg  Pro          
            1645                 1650                 1655              

ttc ctc tgg ctg  ccc agc agc ggg ctg  gca gct gtc aac gtg  tca      5056
Phe Leu Trp Leu  Pro Ser Ser Gly Leu  Ala Ala Val Asn Val  Ser          
            1660                 1665                 1670              

tac ttc ttc aat  ggg cgc ctg gct ggg  ctt cag cgt ggg gcc  atg      5101
Tyr Phe Phe Asn  Gly Arg Leu Ala Gly  Leu Gln Arg Gly Ala  Met          
            1675                 1680                 1685              

agc gag agg aca  gac atc gac aag caa  ggc cgc atc gtg tcc  cgc      5146
Ser Glu Arg Thr  Asp Ile Asp Lys Gln  Gly Arg Ile Val Ser  Arg          
            1690                 1695                 1700              

atg ttc gct gac  ggg aaa gtg tgg agc  tac tcc tac ctt gac  aag      5191
Met Phe Ala Asp  Gly Lys Val Trp Ser  Tyr Ser Tyr Leu Asp  Lys          
            1705                 1710                 1715              

tcc atg gtc ctc  ctg ctt cag agc caa  cgt cag tat ata ttt  gag      5236
Ser Met Val Leu  Leu Leu Gln Ser Gln  Arg Gln Tyr Ile Phe  Glu          
            1720                 1725                 1730              

tat gac tcc tct  gac cgc ctc ctt gcc  gtc acc atg ccc agc  gtg      5281
Tyr Asp Ser Ser  Asp Arg Leu Leu Ala  Val Thr Met Pro Ser  Val          
            1735                 1740                 1745              

gcc cgg cac agc  atg tcc aca cac acc  tcc atc ggc tac atc  cgt      5326
Ala Arg His Ser  Met Ser Thr His Thr  Ser Ile Gly Tyr Ile  Arg          
            1750                 1755                 1760              

aat att tac aac  ccg cct gaa agc aat  gct tcg gtc atc ttt  gac      5371
Asn Ile Tyr Asn  Pro Pro Glu Ser Asn  Ala Ser Val Ile Phe  Asp          
            1765                 1770                 1775              

tac agt gat gac  ggc cgc atc ctg aag  acc tcc ttt ttg ggc  acc      5416
Tyr Ser Asp Asp  Gly Arg Ile Leu Lys  Thr Ser Phe Leu Gly  Thr          
            1780                 1785                 1790              

gga cgc cag gtg  ttc tac aag tat ggg  aaa ctc tcc aag tta  tca      5461
Gly Arg Gln Val  Phe Tyr Lys Tyr Gly  Lys Leu Ser Lys Leu  Ser          
            1795                 1800                 1805              

gag att gtc tac  gac agt acc gcc gtc  acc ttc ggg tat gac  gag      5506
Glu Ile Val Tyr  Asp Ser Thr Ala Val  Thr Phe Gly Tyr Asp  Glu          
            1810                 1815                 1820              

acc act ggt gtc  ttg aag atg gtc aac  ctc caa agt ggg ggc  ttc      5551
Thr Thr Gly Val  Leu Lys Met Val Asn  Leu Gln Ser Gly Gly  Phe          
            1825                 1830                 1835              

tcc tgc acc atc  agg tac cgg aag att  ggc ccc ctg gtg gac  aag      5596
Ser Cys Thr Ile  Arg Tyr Arg Lys Ile  Gly Pro Leu Val Asp  Lys          
            1840                 1845                 1850              

cag atc tac agg  ttc tcc gag gaa ggc  atg gtc aat gcc agg  ttt      5641
Gln Ile Tyr Arg  Phe Ser Glu Glu Gly  Met Val Asn Ala Arg  Phe          
            1855                 1860                 1865              

gac tac acc tat  cat gac aac agc ttc  cgc atc gca agc atc  aag      5686
Asp Tyr Thr Tyr  His Asp Asn Ser Phe  Arg Ile Ala Ser Ile  Lys          
            1870                 1875                 1880              

ccc gtc ata agt  gag act ccc ctc ccc  gtt gac ctc tac cgc  tat      5731
Pro Val Ile Ser  Glu Thr Pro Leu Pro  Val Asp Leu Tyr Arg  Tyr          
            1885                 1890                 1895              

gat gag att tct  ggc aag gtg gaa cac  ttt ggt aag ttt gga  gtc      5776
Asp Glu Ile Ser  Gly Lys Val Glu His  Phe Gly Lys Phe Gly  Val          
            1900                 1905                 1910              

atc tat tat gac  atc aac cag atc atc  acc act gcc gtg atg  acc      5821
Ile Tyr Tyr Asp  Ile Asn Gln Ile Ile  Thr Thr Ala Val Met  Thr          
            1915                 1920                 1925              

ctc agc aaa cac  ttc gac acc cat ggg  cgg atc aag gag gtc  cag      5866
Leu Ser Lys His  Phe Asp Thr His Gly  Arg Ile Lys Glu Val  Gln          
            1930                 1935                 1940              

tat gag atg ttc  cgg tcc ctc atg tac  tgg atg acg gtg caa  tat      5911
Tyr Glu Met Phe  Arg Ser Leu Met Tyr  Trp Met Thr Val Gln  Tyr          
            1945                 1950                 1955              

gac agc atg ggc  agg gtg atc aag agg  gag cta aaa ctg ggg  ccc      5956
Asp Ser Met Gly  Arg Val Ile Lys Arg  Glu Leu Lys Leu Gly  Pro          
            1960                 1965                 1970              

tat gcc aat acc  acg aag tac acc tat  gac tac gat ggg gac  ggg      6001
Tyr Ala Asn Thr  Thr Lys Tyr Thr Tyr  Asp Tyr Asp Gly Asp  Gly          
            1975                 1980                 1985              

cag ctc cag agc  gtg gcc gtc aat gac  cgc ccg acc tgg cgc  tac      6046
Gln Leu Gln Ser  Val Ala Val Asn Asp  Arg Pro Thr Trp Arg  Tyr          
            1990                 1995                 2000              

agc tat gac ctt  aat ggg aat ctc cac  tta ctg aac cca ggc  aac      6091
Ser Tyr Asp Leu  Asn Gly Asn Leu His  Leu Leu Asn Pro Gly  Asn          
            2005                 2010                 2015              

agt gtg cgc ctc  atg ccc ttg cgc tat  gac ctc cgg gat cgg  ata      6136
Ser Val Arg Leu  Met Pro Leu Arg Tyr  Asp Leu Arg Asp Arg  Ile          
            2020                 2025                 2030              

acc aga ctc ggg  gat gtg cag tac aaa  att gac gac gat ggc  tat      6181
Thr Arg Leu Gly  Asp Val Gln Tyr Lys  Ile Asp Asp Asp Gly  Tyr          
            2035                 2040                 2045              

ctg tgc cag aga  ggg tct gac atc ttc  gaa tac aat tcc aag  ggc      6226
Leu Cys Gln Arg  Gly Ser Asp Ile Phe  Glu Tyr Asn Ser Lys  Gly          
            2050                 2055                 2060              

ctc cta aca aga  gcc tac aac aag gcc  agc ggg tgg agt gtc  cag      6271
Leu Leu Thr Arg  Ala Tyr Asn Lys Ala  Ser Gly Trp Ser Val  Gln          
            2065                 2070                 2075              

tac cgc tat gat  ggc gta gga cgg cgg  gct tcc tac aag acc  aac      6316
Tyr Arg Tyr Asp  Gly Val Gly Arg Arg  Ala Ser Tyr Lys Thr  Asn          
            2080                 2085                 2090              

ctg ggc cac cac  ctg cag tac ttc tac  tct gac ctc cac aac  ccg      6361
Leu Gly His His  Leu Gln Tyr Phe Tyr  Ser Asp Leu His Asn  Pro          
            2095                 2100                 2105              

acg cgc atc acc  cat gtc tac aat cac  tcc aac tcg gag att  acc      6406
Thr Arg Ile Thr  His Val Tyr Asn His  Ser Asn Ser Glu Ile  Thr          
            2110                 2115                 2120              

tca ctg tac tac  gac ctc cag ggc cac  ctc ttt gcc atg gag  agc      6451
Ser Leu Tyr Tyr  Asp Leu Gln Gly His  Leu Phe Ala Met Glu  Ser          
            2125                 2130                 2135              

agc agt ggg gag  gag tac tat gtt gcc  tct gat aac aca ggg  act      6496
Ser Ser Gly Glu  Glu Tyr Tyr Val Ala  Ser Asp Asn Thr Gly  Thr          
            2140                 2145                 2150              

cct ctg gct gtg  ttc agc atc aac ggc  ctc atg atc aaa cag  ctg      6541
Pro Leu Ala Val  Phe Ser Ile Asn Gly  Leu Met Ile Lys Gln  Leu          
            2155                 2160                 2165              

cag tac acg gcc  tat ggg gag att tat  tat gac tcc aac ccc  gac      6586
Gln Tyr Thr Ala  Tyr Gly Glu Ile Tyr  Tyr Asp Ser Asn Pro  Asp          
            2170                 2175                 2180              

ttc cag atg gtc  att ggc ttc cat ggg  gga ctc tat gac ccc  ctg      6631
Phe Gln Met Val  Ile Gly Phe His Gly  Gly Leu Tyr Asp Pro  Leu          
            2185                 2190                 2195              

acc aag ctg gtc  cac ttc act cag cgt  gat tat gat gtg ctg  gca      6676
Thr Lys Leu Val  His Phe Thr Gln Arg  Asp Tyr Asp Val Leu  Ala          
            2200                 2205                 2210              

gga cga tgg acc  tcc cca gac tat acc  atg tgg aaa aac gtg  ggc      6721
Gly Arg Trp Thr  Ser Pro Asp Tyr Thr  Met Trp Lys Asn Val  Gly          
            2215                 2220                 2225              

aag gag ccg gcc  ccc ttt aac ctg tat  atg ttc aag agc aac  aat      6766
Lys Glu Pro Ala  Pro Phe Asn Leu Tyr  Met Phe Lys Ser Asn  Asn          
            2230                 2235                 2240              

cct ctc agc agt  gag cta gat ttg aag  aac tac gtg aca gat  gtg      6811
Pro Leu Ser Ser  Glu Leu Asp Leu Lys  Asn Tyr Val Thr Asp  Val          
            2245                 2250                 2255              

aaa agc tgg ctt  gtg atg ttt gga ttt  cag ctt agc aac atc  att      6856
Lys Ser Trp Leu  Val Met Phe Gly Phe  Gln Leu Ser Asn Ile  Ile          
            2260                 2265                 2270              

cct ggc ttc ccg  aga gcc aaa atg tat  ttc gtg cct cct ccc  tat      6901
Pro Gly Phe Pro  Arg Ala Lys Met Tyr  Phe Val Pro Pro Pro  Tyr          
            2275                 2280                 2285              

gaa ttg tca gag  agt caa gca agt gag  aat gga cag ctc att  aca      6946
Glu Leu Ser Glu  Ser Gln Ala Ser Glu  Asn Gly Gln Leu Ile  Thr          
            2290                 2295                 2300              

ggt gtc caa cag  aca aca gag aga cat  aac cag gcc ttc atg  gct      6991
Gly Val Gln Gln  Thr Thr Glu Arg His  Asn Gln Ala Phe Met  Ala          
            2305                 2310                 2315              

ctg gaa gga cag  gtc att act aaa aag  ctc cac gcc agc atc  cga      7036
Leu Glu Gly Gln  Val Ile Thr Lys Lys  Leu His Ala Ser Ile  Arg          
            2320                 2325                 2330              

gag aaa gca ggt  cac tgg ttt gcc acc  acc acg ccc atc att  ggc      7081
Glu Lys Ala Gly  His Trp Phe Ala Thr  Thr Thr Pro Ile Ile  Gly          
            2335                 2340                 2345              

aaa ggc atc atg  ttt gcc atc aaa gaa  ggg cgg gtg acc acg  ggc      7126
Lys Gly Ile Met  Phe Ala Ile Lys Glu  Gly Arg Val Thr Thr  Gly          
            2350                 2355                 2360              

gtg tcc agc atc  gcc agc gaa gat agc  cgc aag gtg gca tct  gtg      7171
Val Ser Ser Ile  Ala Ser Glu Asp Ser  Arg Lys Val Ala Ser  Val          
            2365                 2370                 2375              

ctg aac aac gcc  tac tac ctg gac aag  atg cac tac agc atc  gag      7216
Leu Asn Asn Ala  Tyr Tyr Leu Asp Lys  Met His Tyr Ser Ile  Glu          
            2380                 2385                 2390              

ggc aag gac acc  cac tac ttt gtg aag  att ggc tca gcc gat  ggc      7261
Gly Lys Asp Thr  His Tyr Phe Val Lys  Ile Gly Ser Ala Asp  Gly          
            2395                 2400                 2405              

gac ctg gtc aca  cta ggc acc acc atc  ggc cgc aag gtg cta  gag      7306
Asp Leu Val Thr  Leu Gly Thr Thr Ile  Gly Arg Lys Val Leu  Glu          
            2410                 2415                 2420              

agc ggg gtg aac  gtg acc gtg tcc cag  ccc acg ctg ctg gtc  aac      7351
Ser Gly Val Asn  Val Thr Val Ser Gln  Pro Thr Leu Leu Val  Asn          
            2425                 2430                 2435              

ggc agg act cga  agg ttc acg aac att  gag ttc cag tac tcc  acg      7396
Gly Arg Thr Arg  Arg Phe Thr Asn Ile  Glu Phe Gln Tyr Ser  Thr          
            2440                 2445                 2450              

ctg ctg ctc agc  atc cgc tat ggc ctc  acc ccc gac acc ctg  gac      7441
Leu Leu Leu Ser  Ile Arg Tyr Gly Leu  Thr Pro Asp Thr Leu  Asp          
            2455                 2460                 2465              

gaa gag aag gcc  cgc gtc ctg gac cag  gcg aga cag agg gcc  ctg      7486
Glu Glu Lys Ala  Arg Val Leu Asp Gln  Ala Arg Gln Arg Ala  Leu          
            2470                 2475                 2480              

ggc acg gcc tgg  gcc aag gag cag cag  aaa gcc agg gac ggg  aga      7531
Gly Thr Ala Trp  Ala Lys Glu Gln Gln  Lys Ala Arg Asp Gly  Arg          
            2485                 2490                 2495              

gag ggg agc cgc  ctg tgg act gag ggc  gag aag cag cag ctt  ctg      7576
Glu Gly Ser Arg  Leu Trp Thr Glu Gly  Glu Lys Gln Gln Leu  Leu          
            2500                 2505                 2510              

agc acc ggg cgc  gtg caa ggg tac gag  gga tat tac gtg ctt  ccc      7621
Ser Thr Gly Arg  Val Gln Gly Tyr Glu  Gly Tyr Tyr Val Leu  Pro          
            2515                 2520                 2525              

gtg gag caa tac  cca gag ctt gca gac  agt agc agc aac atc  cag      7666
Val Glu Gln Tyr  Pro Glu Leu Ala Asp  Ser Ser Ser Asn Ile  Gln          
            2530                 2535                 2540              

ttt tta aga cag  aat gag atg gga aag  agg taa caaaataatc            7709
Phe Leu Arg Gln  Asn Glu Met Gly Lys  Arg                               
            2545                 2550                                   

tgctgccatt ccttgtctga atggctcagc aggagtaact gttatctcct ctcctaagga   7769

gatgaagacc taacaggggc actgcggctg ggctgcttta ggagaccaag tggcaagaaa   7829

gctcacattt tttgagttca aatgctactg tccaagcgag aagtccctca tcctgaagta   7889

gactaaagcc cggctgaaaa ttccgaggaa aacaaaacaa acgaatgaat gaacagacac   7949

acacaatgtt ccaagttccc ctaaaatatg acccacttgt tctgggtcta cgcagaaaag   8009

agacgcaaag tgtccaaaag gaacaaaaga acaaaaacga ataagcaaag aagaaaacaa   8069

acaaaaacaa aacaaaacaa acacacggac cgataaacaa agaagcgaag ataagaaaga   8129

aggcctcata tccaattacc tcactcattc acatgtgagc gacacgcaga catccgcgag   8189

ggccagcgtc accagaccag ctgcgggaca aaccactcag actgcttgta ggacaaatac   8249

ttctgacatt ttcgtttaag caaatacagg tgcatttaaa acacgacttt gggggtgatt   8309

tgtgtgtagc gcctggggag gggggataaa agaggaggag tgagcactgg aaatactttt   8369

taaagaaaaa aaaacatgag ggaataaaag aaattcctat caaaaatcaa agtgaaataa   8429

taccatccag cacttaactc tcaggtccca actaagtctg gcctgagcta atttatttga   8489

gcgcagagtg taaaatttaa ttcaaaatgg tggctataat cactacagat aaatttcata   8549

ctcttttgtc tttggagatt ccattgtgga cagtaatacg cagttacagg gtgtagtctg   8609

tttagattcc gtagttcgtg ggtatcagtt tcggtagagg tgcagcatcg tgacactttt   8669

gctaacaggt accacttctg atcaccctgt acatacatga gccgaaaggc acaatcactg   8729

tttcagattt aaaattatta gtgtgtttgt ttggtccaga aactgagaca atcacatgac   8789

agtcaccacg aggagagaaa atttaaaaaa taaaaataaa aacaaaaaaa attttaaaaa   8849

ttaaaaaaac aaaaataaag tctaataaga actttggtac aggaactttt ttgtaatata   8909

catgtatgaa ttgttcatcg agtttttata ttaattttaa tttgctgcta agcaaagact   8969

agggacaggc aaagataatt tatggcaaag tgtttaaatt gtttatacat gaataaagtc   9029

tctaaaactc caaaaaaaaa aaaaaaaaa                                     9058


<210>  80
<211>  2551
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Leu His Ala Ala Asn Lys Gly Arg Lys Pro Ser Ala Glu Ala Gly 
1               5                   10                  15      


Arg Pro Ile Pro Pro Thr Ser Ser Pro Ser Leu Leu Pro Ser Ala Gln 
            20                  25                  30          


Leu Pro Ser Ser His Asn Pro Pro Pro Val Ser Cys Gln Met Pro Leu 
        35                  40                  45              


Leu Asp Ser Asn Thr Ser His Gln Ile Met Asp Thr Asn Pro Asp Glu 
    50                  55                  60                  


Glu Phe Ser Pro Asn Ser Tyr Leu Leu Arg Ala Cys Ser Gly Pro Gln 
65                  70                  75                  80  


Gln Ala Ser Ser Ser Gly Pro Pro Asn His His Ser Gln Ser Thr Leu 
                85                  90                  95      


Arg Pro Pro Leu Pro Pro Pro His Asn His Thr Leu Ser His His His 
            100                 105                 110         


Ser Ser Ala Asn Ser Leu Asn Arg Asn Ser Leu Thr Asn Arg Arg Ser 
        115                 120                 125             


Gln Ile His Ala Pro Ala Pro Ala Pro Asn Asp Leu Ala Thr Thr Pro 
    130                 135                 140                 


Glu Ser Val Gln Leu Gln Asp Ser Trp Val Leu Asn Ser Asn Val Pro 
145                 150                 155                 160 


Leu Glu Thr Arg His Phe Leu Phe Lys Thr Ser Ser Gly Ser Thr Pro 
                165                 170                 175     


Leu Phe Ser Ser Ser Ser Pro Gly Tyr Pro Leu Thr Ser Gly Thr Val 
            180                 185                 190         


Tyr Thr Pro Pro Pro Arg Leu Leu Pro Arg Asn Thr Phe Ser Arg Lys 
        195                 200                 205             


Ala Phe Lys Leu Lys Lys Pro Ser Lys Tyr Cys Ser Trp Lys Cys Ala 
    210                 215                 220                 


Ala Leu Ser Ala Ile Ala Ala Ala Leu Leu Leu Ala Ile Leu Leu Ala 
225                 230                 235                 240 


Tyr Phe Ile Ala Met His Leu Leu Gly Leu Asn Trp Gln Leu Gln Pro 
                245                 250                 255     


Ala Asp Gly His Thr Phe Asn Asn Gly Ile Arg Thr Gly Leu Pro Gly 
            260                 265                 270         


Asn Asp Asp Val Ala Thr Met Pro Ser Gly Gly Lys Val Pro Trp Ser 
        275                 280                 285             


Leu Lys Asn Ser Ser Ile Asp Ser Gly Glu Ala Glu Val Gly Arg Arg 
    290                 295                 300                 


Val Thr Gln Glu Val Pro Pro Gly Val Phe Trp Arg Ser Gln Ile His 
305                 310                 315                 320 


Ile Ser Gln Pro Gln Phe Leu Lys Phe Asn Ile Ser Leu Gly Lys Asp 
                325                 330                 335     


Ala Leu Phe Gly Val Tyr Ile Arg Arg Gly Leu Pro Pro Ser His Ala 
            340                 345                 350         


Gln Tyr Asp Phe Met Glu Arg Leu Asp Gly Lys Glu Lys Trp Ser Val 
        355                 360                 365             


Val Glu Ser Pro Arg Glu Arg Arg Ser Ile Gln Thr Leu Val Gln Asn 
    370                 375                 380                 


Glu Ala Val Phe Val Gln Tyr Leu Asp Val Gly Leu Trp His Leu Ala 
385                 390                 395                 400 


Phe Tyr Asn Asp Gly Lys Asp Lys Glu Met Val Ser Phe Asn Thr Val 
                405                 410                 415     


Val Leu Asp Ser Val Gln Asp Cys Pro Arg Asn Cys His Gly Asn Gly 
            420                 425                 430         


Glu Cys Val Ser Gly Val Cys His Cys Phe Pro Gly Phe Leu Gly Ala 
        435                 440                 445             


Asp Cys Ala Lys Ala Ala Cys Pro Val Leu Cys Ser Gly Asn Gly Gln 
    450                 455                 460                 


Tyr Ser Lys Gly Thr Cys Gln Cys Tyr Ser Gly Trp Lys Gly Ala Glu 
465                 470                 475                 480 


Cys Asp Val Pro Met Asn Gln Cys Ile Asp Pro Ser Cys Gly Gly His 
                485                 490                 495     


Gly Ser Cys Ile Asp Gly Asn Cys Val Cys Ser Ala Gly Tyr Lys Gly 
            500                 505                 510         


Glu His Cys Glu Glu Val Asp Cys Leu Asp Pro Thr Cys Ser Ser His 
        515                 520                 525             


Gly Val Cys Val Asn Gly Glu Cys Leu Cys Ser Pro Gly Trp Gly Gly 
    530                 535                 540                 


Leu Asn Cys Glu Leu Ala Arg Val Gln Cys Pro Asp Gln Cys Ser Gly 
545                 550                 555                 560 


His Gly Thr Tyr Leu Pro Asp Thr Gly Leu Cys Ser Cys Asp Pro Asn 
                565                 570                 575     


Trp Met Gly Pro Asp Cys Ser Val Asp Gly Cys Pro Asp Leu Cys Asn 
            580                 585                 590         


Gly Asn Gly Arg Cys Thr Leu Gly Gln Asn Ser Trp Gln Cys Val Cys 
        595                 600                 605             


Gln Thr Gly Trp Arg Gly Pro Gly Cys Asn Val Ala Met Glu Thr Ser 
    610                 615                 620                 


Cys Ala Asp Asn Lys Asp Asn Glu Gly Asp Gly Leu Val Asp Cys Leu 
625                 630                 635                 640 


Asp Pro Asp Cys Cys Leu Gln Ser Ala Cys Gln Asn Ser Leu Leu Cys 
                645                 650                 655     


Arg Gly Ser Arg Asp Pro Leu Asp Ile Ile Gln Gln Gly Gln Thr Asp 
            660                 665                 670         


Trp Pro Ala Val Lys Ser Phe Tyr Asp Arg Ile Lys Leu Leu Ala Gly 
        675                 680                 685             


Lys Asp Ser Thr His Ile Ile Pro Gly Glu Asn Pro Phe Asn Ser Ser 
    690                 695                 700                 


Leu Val Ser Leu Ile Arg Gly Gln Val Val Thr Thr Asp Gly Thr Pro 
705                 710                 715                 720 


Leu Val Gly Val Asn Val Ser Phe Val Lys Tyr Pro Lys Tyr Gly Tyr 
                725                 730                 735     


Thr Ile Thr Arg Gln Asp Gly Thr Phe Asp Leu Ile Ala Asn Gly Gly 
            740                 745                 750         


Ala Ser Leu Thr Leu His Phe Glu Arg Ala Pro Phe Met Ser Gln Glu 
        755                 760                 765             


Arg Thr Val Trp Leu Pro Trp Asn Ser Phe Tyr Ala Met Asp Thr Leu 
    770                 775                 780                 


Val Met Lys Thr Glu Glu Asn Ser Ile Pro Ser Cys Asp Leu Ser Gly 
785                 790                 795                 800 


Phe Val Arg Pro Asp Pro Ile Ile Ile Ser Ser Pro Leu Ser Thr Phe 
                805                 810                 815     


Phe Ser Ala Ala Pro Gly Gln Asn Pro Ile Val Pro Glu Thr Gln Val 
            820                 825                 830         


Leu His Glu Glu Ile Glu Leu Pro Gly Ser Asn Val Lys Leu Arg Tyr 
        835                 840                 845             


Leu Ser Ser Arg Thr Ala Gly Tyr Lys Ser Leu Leu Lys Ile Thr Met 
    850                 855                 860                 


Thr Gln Ser Thr Val Pro Leu Asn Leu Ile Arg Val His Leu Met Val 
865                 870                 875                 880 


Ala Val Glu Gly His Leu Phe Gln Lys Ser Phe Gln Ala Ser Pro Asn 
                885                 890                 895     


Leu Ala Tyr Thr Phe Ile Trp Asp Lys Thr Asp Ala Tyr Gly Gln Arg 
            900                 905                 910         


Val Tyr Gly Leu Ser Asp Ala Val Val Ser Val Gly Phe Glu Tyr Glu 
        915                 920                 925             


Thr Cys Pro Ser Leu Ile Leu Trp Glu Lys Arg Thr Ala Leu Leu Gln 
    930                 935                 940                 


Gly Phe Glu Leu Asp Pro Ser Asn Leu Gly Gly Trp Ser Leu Asp Lys 
945                 950                 955                 960 


His His Ile Leu Asn Val Lys Ser Gly Ile Leu His Lys Gly Thr Gly 
                965                 970                 975     


Glu Asn Gln Phe Leu Thr Gln Gln Pro Ala Ile Ile Thr Ser Ile Met 
            980                 985                 990         


Gly Asn Gly Arg Arg Arg Ser Ile  Ser Cys Pro Ser Cys  Asn Gly Leu 
        995                 1000                 1005             


Ala Glu  Gly Asn Lys Leu Leu  Ala Pro Val Ala Leu  Ala Val Gly 
    1010                 1015                 1020             


Ile Asp  Gly Ser Leu Tyr Val  Gly Asp Phe Asn Tyr  Ile Arg Arg 
    1025                 1030                 1035             


Ile Phe  Pro Ser Arg Asn Val  Thr Ser Ile Leu Glu  Leu Arg Asn 
    1040                 1045                 1050             


Lys Glu  Phe Lys His Ser Asn  Asn Pro Ala His Lys  Tyr Tyr Leu 
    1055                 1060                 1065             


Ala Val  Asp Pro Val Ser Gly  Ser Leu Tyr Val Ser  Asp Thr Asn 
    1070                 1075                 1080             


Ser Arg  Arg Ile Tyr Arg Val  Lys Ser Leu Ser Gly  Thr Lys Asp 
    1085                 1090                 1095             


Leu Ala  Gly Asn Ser Glu Val  Val Ala Gly Thr Gly  Glu Gln Cys 
    1100                 1105                 1110             


Leu Pro  Phe Asp Glu Ala Arg  Cys Gly Asp Gly Gly  Lys Ala Ile 
    1115                 1120                 1125             


Asp Ala  Thr Leu Met Ser Pro  Arg Gly Ile Ala Val  Asp Lys Asn 
    1130                 1135                 1140             


Gly Leu  Met Tyr Phe Val Asp  Ala Thr Met Ile Arg  Lys Val Asp 
    1145                 1150                 1155             


Gln Asn  Gly Ile Ile Ser Thr  Leu Leu Gly Ser Asn  Asp Leu Thr 
    1160                 1165                 1170             


Ala Val  Arg Pro Leu Ser Cys  Asp Ser Ser Met Asp  Val Ala Gln 
    1175                 1180                 1185             


Val Arg  Leu Glu Trp Pro Thr  Asp Leu Ala Val Asn  Pro Met Asp 
    1190                 1195                 1200             


Asn Ser  Leu Tyr Val Leu Glu  Asn Asn Val Ile Leu  Arg Ile Thr 
    1205                 1210                 1215             


Glu Asn  His Gln Val Ser Ile  Ile Ala Gly Arg Pro  Met His Cys 
    1220                 1225                 1230             


Gln Val  Pro Gly Ile Asp Tyr  Ser Leu Ser Lys Leu  Ala Ile His 
    1235                 1240                 1245             


Ser Ala  Leu Glu Ser Ala Ser  Ala Ile Ala Ile Ser  His Thr Gly 
    1250                 1255                 1260             


Val Leu  Tyr Ile Thr Glu Thr  Asp Glu Lys Lys Ile  Asn Arg Leu 
    1265                 1270                 1275             


Arg Gln  Val Thr Thr Asn Gly  Glu Ile Cys Leu Leu  Ala Gly Ala 
    1280                 1285                 1290             


Ala Ser  Asp Cys Asp Cys Lys  Asn Asp Val Asn Cys  Asn Cys Tyr 
    1295                 1300                 1305             


Ser Gly  Asp Asp Ala Tyr Ala  Thr Asp Ala Ile Leu  Asn Ser Pro 
    1310                 1315                 1320             


Ser Ser  Leu Ala Val Ala Pro  Asp Gly Thr Ile Tyr  Ile Ala Asp 
    1325                 1330                 1335             


Leu Gly  Asn Ile Arg Ile Arg  Ala Val Ser Lys Asn  Lys Pro Val 
    1340                 1345                 1350             


Leu Asn  Ala Phe Asn Gln Tyr  Glu Ala Ala Ser Pro  Gly Glu Gln 
    1355                 1360                 1365             


Glu Leu  Tyr Val Phe Asn Ala  Asp Gly Ile His Gln  Tyr Thr Val 
    1370                 1375                 1380             


Ser Leu  Val Thr Gly Glu Tyr  Leu Tyr Asn Phe Thr  Tyr Ser Thr 
    1385                 1390                 1395             


Asp Asn  Asp Val Thr Glu Leu  Ile Asp Asn Asn Gly  Asn Ser Leu 
    1400                 1405                 1410             


Lys Ile  Arg Arg Asp Ser Ser  Gly Met Pro Arg His  Leu Leu Met 
    1415                 1420                 1425             


Pro Asp  Asn Gln Ile Ile Thr  Leu Thr Val Gly Thr  Asn Gly Gly 
    1430                 1435                 1440             


Leu Lys  Val Val Ser Thr Gln  Asn Leu Glu Leu Gly  Leu Met Thr 
    1445                 1450                 1455             


Tyr Asp  Gly Asn Thr Gly Leu  Leu Ala Thr Lys Ser  Asp Glu Thr 
    1460                 1465                 1470             


Gly Trp  Thr Thr Phe Tyr Asp  Tyr Asp His Glu Gly  Arg Leu Thr 
    1475                 1480                 1485             


Asn Val  Thr Arg Pro Thr Gly  Val Val Thr Ser Leu  His Arg Glu 
    1490                 1495                 1500             


Met Glu  Lys Ser Ile Thr Ile  Asp Ile Glu Asn Ser  Asn Arg Asp 
    1505                 1510                 1515             


Asp Asp  Val Thr Val Ile Thr  Asn Leu Ser Ser Val  Glu Ala Ser 
    1520                 1525                 1530             


Tyr Thr  Val Val Gln Asp Gln  Val Arg Asn Ser Tyr  Gln Leu Cys 
    1535                 1540                 1545             


Asn Asn  Gly Thr Leu Arg Val  Met Tyr Ala Asn Gly  Met Gly Ile 
    1550                 1555                 1560             


Ser Phe  His Ser Glu Pro His  Val Leu Ala Gly Thr  Ile Thr Pro 
    1565                 1570                 1575             


Thr Ile  Gly Arg Cys Asn Ile  Ser Leu Pro Met Glu  Asn Gly Leu 
    1580                 1585                 1590             


Asn Ser  Ile Glu Trp Arg Leu  Arg Lys Glu Gln Ile  Lys Gly Lys 
    1595                 1600                 1605             


Val Thr  Ile Phe Gly Arg Lys  Leu Arg Val His Gly  Arg Asn Leu 
    1610                 1615                 1620             


Leu Ser  Ile Asp Tyr Asp Arg  Asn Ile Arg Thr Glu  Lys Ile Tyr 
    1625                 1630                 1635             


Asp Asp  His Arg Lys Phe Thr  Leu Arg Ile Ile Tyr  Asp Gln Val 
    1640                 1645                 1650             


Gly Arg  Pro Phe Leu Trp Leu  Pro Ser Ser Gly Leu  Ala Ala Val 
    1655                 1660                 1665             


Asn Val  Ser Tyr Phe Phe Asn  Gly Arg Leu Ala Gly  Leu Gln Arg 
    1670                 1675                 1680             


Gly Ala  Met Ser Glu Arg Thr  Asp Ile Asp Lys Gln  Gly Arg Ile 
    1685                 1690                 1695             


Val Ser  Arg Met Phe Ala Asp  Gly Lys Val Trp Ser  Tyr Ser Tyr 
    1700                 1705                 1710             


Leu Asp  Lys Ser Met Val Leu  Leu Leu Gln Ser Gln  Arg Gln Tyr 
    1715                 1720                 1725             


Ile Phe  Glu Tyr Asp Ser Ser  Asp Arg Leu Leu Ala  Val Thr Met 
    1730                 1735                 1740             


Pro Ser  Val Ala Arg His Ser  Met Ser Thr His Thr  Ser Ile Gly 
    1745                 1750                 1755             


Tyr Ile  Arg Asn Ile Tyr Asn  Pro Pro Glu Ser Asn  Ala Ser Val 
    1760                 1765                 1770             


Ile Phe  Asp Tyr Ser Asp Asp  Gly Arg Ile Leu Lys  Thr Ser Phe 
    1775                 1780                 1785             


Leu Gly  Thr Gly Arg Gln Val  Phe Tyr Lys Tyr Gly  Lys Leu Ser 
    1790                 1795                 1800             


Lys Leu  Ser Glu Ile Val Tyr  Asp Ser Thr Ala Val  Thr Phe Gly 
    1805                 1810                 1815             


Tyr Asp  Glu Thr Thr Gly Val  Leu Lys Met Val Asn  Leu Gln Ser 
    1820                 1825                 1830             


Gly Gly  Phe Ser Cys Thr Ile  Arg Tyr Arg Lys Ile  Gly Pro Leu 
    1835                 1840                 1845             


Val Asp  Lys Gln Ile Tyr Arg  Phe Ser Glu Glu Gly  Met Val Asn 
    1850                 1855                 1860             


Ala Arg  Phe Asp Tyr Thr Tyr  His Asp Asn Ser Phe  Arg Ile Ala 
    1865                 1870                 1875             


Ser Ile  Lys Pro Val Ile Ser  Glu Thr Pro Leu Pro  Val Asp Leu 
    1880                 1885                 1890             


Tyr Arg  Tyr Asp Glu Ile Ser  Gly Lys Val Glu His  Phe Gly Lys 
    1895                 1900                 1905             


Phe Gly  Val Ile Tyr Tyr Asp  Ile Asn Gln Ile Ile  Thr Thr Ala 
    1910                 1915                 1920             


Val Met  Thr Leu Ser Lys His  Phe Asp Thr His Gly  Arg Ile Lys 
    1925                 1930                 1935             


Glu Val  Gln Tyr Glu Met Phe  Arg Ser Leu Met Tyr  Trp Met Thr 
    1940                 1945                 1950             


Val Gln  Tyr Asp Ser Met Gly  Arg Val Ile Lys Arg  Glu Leu Lys 
    1955                 1960                 1965             


Leu Gly  Pro Tyr Ala Asn Thr  Thr Lys Tyr Thr Tyr  Asp Tyr Asp 
    1970                 1975                 1980             


Gly Asp  Gly Gln Leu Gln Ser  Val Ala Val Asn Asp  Arg Pro Thr 
    1985                 1990                 1995             


Trp Arg  Tyr Ser Tyr Asp Leu  Asn Gly Asn Leu His  Leu Leu Asn 
    2000                 2005                 2010             


Pro Gly  Asn Ser Val Arg Leu  Met Pro Leu Arg Tyr  Asp Leu Arg 
    2015                 2020                 2025             


Asp Arg  Ile Thr Arg Leu Gly  Asp Val Gln Tyr Lys  Ile Asp Asp 
    2030                 2035                 2040             


Asp Gly  Tyr Leu Cys Gln Arg  Gly Ser Asp Ile Phe  Glu Tyr Asn 
    2045                 2050                 2055             


Ser Lys  Gly Leu Leu Thr Arg  Ala Tyr Asn Lys Ala  Ser Gly Trp 
    2060                 2065                 2070             


Ser Val  Gln Tyr Arg Tyr Asp  Gly Val Gly Arg Arg  Ala Ser Tyr 
    2075                 2080                 2085             


Lys Thr  Asn Leu Gly His His  Leu Gln Tyr Phe Tyr  Ser Asp Leu 
    2090                 2095                 2100             


His Asn  Pro Thr Arg Ile Thr  His Val Tyr Asn His  Ser Asn Ser 
    2105                 2110                 2115             


Glu Ile  Thr Ser Leu Tyr Tyr  Asp Leu Gln Gly His  Leu Phe Ala 
    2120                 2125                 2130             


Met Glu  Ser Ser Ser Gly Glu  Glu Tyr Tyr Val Ala  Ser Asp Asn 
    2135                 2140                 2145             


Thr Gly  Thr Pro Leu Ala Val  Phe Ser Ile Asn Gly  Leu Met Ile 
    2150                 2155                 2160             


Lys Gln  Leu Gln Tyr Thr Ala  Tyr Gly Glu Ile Tyr  Tyr Asp Ser 
    2165                 2170                 2175             


Asn Pro  Asp Phe Gln Met Val  Ile Gly Phe His Gly  Gly Leu Tyr 
    2180                 2185                 2190             


Asp Pro  Leu Thr Lys Leu Val  His Phe Thr Gln Arg  Asp Tyr Asp 
    2195                 2200                 2205             


Val Leu  Ala Gly Arg Trp Thr  Ser Pro Asp Tyr Thr  Met Trp Lys 
    2210                 2215                 2220             


Asn Val  Gly Lys Glu Pro Ala  Pro Phe Asn Leu Tyr  Met Phe Lys 
    2225                 2230                 2235             


Ser Asn  Asn Pro Leu Ser Ser  Glu Leu Asp Leu Lys  Asn Tyr Val 
    2240                 2245                 2250             


Thr Asp  Val Lys Ser Trp Leu  Val Met Phe Gly Phe  Gln Leu Ser 
    2255                 2260                 2265             


Asn Ile  Ile Pro Gly Phe Pro  Arg Ala Lys Met Tyr  Phe Val Pro 
    2270                 2275                 2280             


Pro Pro  Tyr Glu Leu Ser Glu  Ser Gln Ala Ser Glu  Asn Gly Gln 
    2285                 2290                 2295             


Leu Ile  Thr Gly Val Gln Gln  Thr Thr Glu Arg His  Asn Gln Ala 
    2300                 2305                 2310             


Phe Met  Ala Leu Glu Gly Gln  Val Ile Thr Lys Lys  Leu His Ala 
    2315                 2320                 2325             


Ser Ile  Arg Glu Lys Ala Gly  His Trp Phe Ala Thr  Thr Thr Pro 
    2330                 2335                 2340             


Ile Ile  Gly Lys Gly Ile Met  Phe Ala Ile Lys Glu  Gly Arg Val 
    2345                 2350                 2355             


Thr Thr  Gly Val Ser Ser Ile  Ala Ser Glu Asp Ser  Arg Lys Val 
    2360                 2365                 2370             


Ala Ser  Val Leu Asn Asn Ala  Tyr Tyr Leu Asp Lys  Met His Tyr 
    2375                 2380                 2385             


Ser Ile  Glu Gly Lys Asp Thr  His Tyr Phe Val Lys  Ile Gly Ser 
    2390                 2395                 2400             


Ala Asp  Gly Asp Leu Val Thr  Leu Gly Thr Thr Ile  Gly Arg Lys 
    2405                 2410                 2415             


Val Leu  Glu Ser Gly Val Asn  Val Thr Val Ser Gln  Pro Thr Leu 
    2420                 2425                 2430             


Leu Val  Asn Gly Arg Thr Arg  Arg Phe Thr Asn Ile  Glu Phe Gln 
    2435                 2440                 2445             


Tyr Ser  Thr Leu Leu Leu Ser  Ile Arg Tyr Gly Leu  Thr Pro Asp 
    2450                 2455                 2460             


Thr Leu  Asp Glu Glu Lys Ala  Arg Val Leu Asp Gln  Ala Arg Gln 
    2465                 2470                 2475             


Arg Ala  Leu Gly Thr Ala Trp  Ala Lys Glu Gln Gln  Lys Ala Arg 
    2480                 2485                 2490             


Asp Gly  Arg Glu Gly Ser Arg  Leu Trp Thr Glu Gly  Glu Lys Gln 
    2495                 2500                 2505             


Gln Leu  Leu Ser Thr Gly Arg  Val Gln Gly Tyr Glu  Gly Tyr Tyr 
    2510                 2515                 2520             


Val Leu  Pro Val Glu Gln Tyr  Pro Glu Leu Ala Asp  Ser Ser Ser 
    2525                 2530                 2535             


Asn Ile  Gln Phe Leu Arg Gln  Asn Glu Met Gly Lys  Arg 
    2540                 2545                 2550     


<210>  81
<211>  9695
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (435)..(8336)
<223>  

<400>  81
gtaaccgtca gaattttgta ataacgactc actatagggc ggccgcgaat tcggcacgag     60

tcgaagtgaa ggaattttgc tccaaagcga gctgggaccg aagactctag gctaagttat    120

ctatgtagat ggtgtcaggg agcgaagcta ctgaccgagc tgctgacact ggagacagaa    180

cagtgagcaa cagagacaaa tcctctcttc tcctacagtt tgcatcgcag taagaaagaa    240

ctaagttaca tccagctttt taattgccta agcggtctgg ggcttgcttc gtcatttggc    300

tttgctgtgg agcactcctg taaagccagc tgaattgtac atcgaagatc cacccttttg    360

gtggcaaagt gacaagtgcc aaaactcagg cctgactttt ctgaaaacat cagcattctg    420

ccatatctgg aata atg gat gta aag gac cgg cga cac cgc tct ttg acc      470
                Met Asp Val Lys Asp Arg Arg His Arg Ser Leu Thr         
                1               5                   10                  

aga gga cgc tgt ggc aaa gag tgt cgc tac aca agc tcc tct ctg gac      518
Arg Gly Arg Cys Gly Lys Glu Cys Arg Tyr Thr Ser Ser Ser Leu Asp         
        15                  20                  25                      

agt gag gac tgc cgc gtg ccc aca cag aaa tcc tac agc tcc agt gag      566
Ser Glu Asp Cys Arg Val Pro Thr Gln Lys Ser Tyr Ser Ser Ser Glu         
    30                  35                  40                          

act ctg aag gcc tat gac cat gac agc agg atg cac tat gga aac cga      614
Thr Leu Lys Ala Tyr Asp His Asp Ser Arg Met His Tyr Gly Asn Arg         
45                  50                  55                  60          

gtc aca gac ctc atc cac cgg gag tca gat gag ttt cct aga caa gga      662
Val Thr Asp Leu Ile His Arg Glu Ser Asp Glu Phe Pro Arg Gln Gly         
                65                  70                  75              

acc aac ttc acc ctt gcc gaa ctg ggc atc tgt gag ccc tcc cca cac      710
Thr Asn Phe Thr Leu Ala Glu Leu Gly Ile Cys Glu Pro Ser Pro His         
            80                  85                  90                  

cga agc ggc tac tgc tcc gac atg ggg atc ctt cac cag ggc tac tcc      758
Arg Ser Gly Tyr Cys Ser Asp Met Gly Ile Leu His Gln Gly Tyr Ser         
        95                  100                 105                     

ctt agc aca ggg tct gac gcc gac tcc gac acc gag gga ggg atg tct      806
Leu Ser Thr Gly Ser Asp Ala Asp Ser Asp Thr Glu Gly Gly Met Ser         
    110                 115                 120                         

cca gaa cac gcc atc aga ctg tgg ggc aga ggg ata aaa tcc agg cgc      854
Pro Glu His Ala Ile Arg Leu Trp Gly Arg Gly Ile Lys Ser Arg Arg         
125                 130                 135                 140         

agt tcc ggc ctg tcc agt cgt gaa aac tcg gcc ctt acc ctg act gac      902
Ser Ser Gly Leu Ser Ser Arg Glu Asn Ser Ala Leu Thr Leu Thr Asp         
                145                 150                 155             

tct gac aac gaa aac aaa tca gat gat gag aac ggc cct ccg aac cac      950
Ser Asp Asn Glu Asn Lys Ser Asp Asp Glu Asn Gly Pro Pro Asn His         
            160                 165                 170                 

cac agc cag tcg act ctg agg ccc cct ctc cca ccc cct cac aac cac      998
His Ser Gln Ser Thr Leu Arg Pro Pro Leu Pro Pro Pro His Asn His         
        175                 180                 185                     

acg ctg tcc cat cac cac tcg tcc gcc aac tcc ctc aac agg aac tca     1046
Thr Leu Ser His His His Ser Ser Ala Asn Ser Leu Asn Arg Asn Ser         
    190                 195                 200                         

ctg acc aat cgg cgg agt cag atc cac gcc ccg gcc cca gcg ccc aat     1094
Leu Thr Asn Arg Arg Ser Gln Ile His Ala Pro Ala Pro Ala Pro Asn         
205                 210                 215                 220         

gac ctg gcc acc aca cca gag tcc gtt cag ctt cag gac agc tgg gtg     1142
Asp Leu Ala Thr Thr Pro Glu Ser Val Gln Leu Gln Asp Ser Trp Val         
                225                 230                 235             

cta aac agc aac gtg cca ctg gag acc cgg cac ttc ctc ttc aag acc     1190
Leu Asn Ser Asn Val Pro Leu Glu Thr Arg His Phe Leu Phe Lys Thr         
            240                 245                 250                 

tcc tcg ggg agc aca ccc ttg ttc agc agc tct tcc ccg gga tac cct     1238
Ser Ser Gly Ser Thr Pro Leu Phe Ser Ser Ser Ser Pro Gly Tyr Pro         
        255                 260                 265                     

ttg acc tca gga acg gtt tac acg ccc ccg ccc cgc ctg ctg ccc agg     1286
Leu Thr Ser Gly Thr Val Tyr Thr Pro Pro Pro Arg Leu Leu Pro Arg         
    270                 275                 280                         

aat act ttc tcc agg aag gct ttc aag ctg aag aag ccc tcc aaa tac     1334
Asn Thr Phe Ser Arg Lys Ala Phe Lys Leu Lys Lys Pro Ser Lys Tyr         
285                 290                 295                 300         

tgc agc tgg aaa tgt gct gcc ctc tcc gcc att gcc gcg gcc ctc ctc     1382
Cys Ser Trp Lys Cys Ala Ala Leu Ser Ala Ile Ala Ala Ala Leu Leu         
                305                 310                 315             

ttg gct att ttg ctg gcg tat ttc ata gca atg cat ctg ctc gga ctc     1430
Leu Ala Ile Leu Leu Ala Tyr Phe Ile Ala Met His Leu Leu Gly Leu         
            320                 325                 330                 

aat tgg caa ctc cag cct gca gat ggg cac acc ttt aac aat ggg ata     1478
Asn Trp Gln Leu Gln Pro Ala Asp Gly His Thr Phe Asn Asn Gly Ile         
        335                 340                 345                     

agg acc ggc tta cca gga aac gat gat gtg gca aca atg cca tct gga     1526
Arg Thr Gly Leu Pro Gly Asn Asp Asp Val Ala Thr Met Pro Ser Gly         
    350                 355                 360                         

ggc aaa gtg ccc tgg tcg ttg aaa aac agc agc ata gac agt ggt gaa     1574
Gly Lys Val Pro Trp Ser Leu Lys Asn Ser Ser Ile Asp Ser Gly Glu         
365                 370                 375                 380         

gca gaa gtt ggt cgg cgg gta aca caa gaa gtc cca cca ggg gtg ttt     1622
Ala Glu Val Gly Arg Arg Val Thr Gln Glu Val Pro Pro Gly Val Phe         
                385                 390                 395             

tgg agg tca caa att cac atc agt cag ccc cag ttc tta aag ttc aac     1670
Trp Arg Ser Gln Ile His Ile Ser Gln Pro Gln Phe Leu Lys Phe Asn         
            400                 405                 410                 

atc tcc ctc ggg aag gac gct ctc ttt ggt gtt tac ata aga aga gga     1718
Ile Ser Leu Gly Lys Asp Ala Leu Phe Gly Val Tyr Ile Arg Arg Gly         
        415                 420                 425                     

ctt cca cca tct cat gcc cag tat gac ttc atg gaa cgt ctg gac ggg     1766
Leu Pro Pro Ser His Ala Gln Tyr Asp Phe Met Glu Arg Leu Asp Gly         
    430                 435                 440                         

aag gag aag tgg agt gtg gtt gag tct ccc agg gaa cgc cgg agc ata     1814
Lys Glu Lys Trp Ser Val Val Glu Ser Pro Arg Glu Arg Arg Ser Ile         
445                 450                 455                 460         

cag acc ttg gtt cag aat gaa gcc gtg ttt gtg cag tac ctg gat gtg     1862
Gln Thr Leu Val Gln Asn Glu Ala Val Phe Val Gln Tyr Leu Asp Val         
                465                 470                 475             

ggc ctg tgg cat ctg gcc ttc tac aat gat gga aaa gac aaa gag atg     1910
Gly Leu Trp His Leu Ala Phe Tyr Asn Asp Gly Lys Asp Lys Glu Met         
            480                 485                 490                 

gtt tcc ttc aat act gtt gtc cta gat tca gtg cag gac tgt cca cgt     1958
Val Ser Phe Asn Thr Val Val Leu Asp Ser Val Gln Asp Cys Pro Arg         
        495                 500                 505                     

aac tgc cat ggg aat ggt gaa tgt gtg tcc ggg gtg tgt cac tgt ttc     2006
Asn Cys His Gly Asn Gly Glu Cys Val Ser Gly Val Cys His Cys Phe         
    510                 515                 520                         

cca gga ttt cta gga gca gac tgt gct aaa gct gcc tgc cct gtc ctg     2054
Pro Gly Phe Leu Gly Ala Asp Cys Ala Lys Ala Ala Cys Pro Val Leu         
525                 530                 535                 540         

tgc agt ggg aat gga caa tat tct aaa ggg acg tgc cag tgc tac agc     2102
Cys Ser Gly Asn Gly Gln Tyr Ser Lys Gly Thr Cys Gln Cys Tyr Ser         
                545                 550                 555             

ggc tgg aaa ggt gca gag tgc gac gtg ccc atg aat cag tgc atc gat     2150
Gly Trp Lys Gly Ala Glu Cys Asp Val Pro Met Asn Gln Cys Ile Asp         
            560                 565                 570                 

cct tcc tgc ggg ggc cac ggc tcc tgc att gat ggg aac tgt gtc tgc     2198
Pro Ser Cys Gly Gly His Gly Ser Cys Ile Asp Gly Asn Cys Val Cys         
        575                 580                 585                     

tct gct ggc tac aaa ggc gag cac tgt gag gaa gtt gat tgc ttg gat     2246
Ser Ala Gly Tyr Lys Gly Glu His Cys Glu Glu Val Asp Cys Leu Asp         
    590                 595                 600                         

ccc acc tgc tcc agc cac gga gtc tgt gtg aat gga gaa tgc ctg tgc     2294
Pro Thr Cys Ser Ser His Gly Val Cys Val Asn Gly Glu Cys Leu Cys         
605                 610                 615                 620         

agc cct ggc tgg ggt ggt ctg aac tgt gag ctg gcg agg gtc cag tgc     2342
Ser Pro Gly Trp Gly Gly Leu Asn Cys Glu Leu Ala Arg Val Gln Cys         
                625                 630                 635             

cca gac cag tgc agt ggg cat ggc acg tac ctg cct gac acg ggc ctc     2390
Pro Asp Gln Cys Ser Gly His Gly Thr Tyr Leu Pro Asp Thr Gly Leu         
            640                 645                 650                 

tgc agc tgc gat ccc aac tgg atg ggt ccc gac tgc tct gtt gat ggc     2438
Cys Ser Cys Asp Pro Asn Trp Met Gly Pro Asp Cys Ser Val Asp Gly         
        655                 660                 665                     

tgc cct gac ttg tgc aac ggt aac ggg aga tgc aca ctg ggt cag aac     2486
Cys Pro Asp Leu Cys Asn Gly Asn Gly Arg Cys Thr Leu Gly Gln Asn         
    670                 675                 680                         

agc tgg cag tgt gtc tgc cag acc ggc tgg aga ggg ccc gga tgc aac     2534
Ser Trp Gln Cys Val Cys Gln Thr Gly Trp Arg Gly Pro Gly Cys Asn         
685                 690                 695                 700         

gtt gcc atg gaa act tcc tgt gct gat aac aag gat aat gag gga gat     2582
Val Ala Met Glu Thr Ser Cys Ala Asp Asn Lys Asp Asn Glu Gly Asp         
                705                 710                 715             

ggc ctg gtg gat tgt ttg gac cct gac tgc tgc ctg cag tca gcc tgt     2630
Gly Leu Val Asp Cys Leu Asp Pro Asp Cys Cys Leu Gln Ser Ala Cys         
            720                 725                 730                 

cag aac agc ctg ctc tgc cgg ggg tcc cgg gac cca ctg gac atc att     2678
Gln Asn Ser Leu Leu Cys Arg Gly Ser Arg Asp Pro Leu Asp Ile Ile         
        735                 740                 745                     

cag cag ggc cag acg gat tgg ccc gca gtg aag tcc ttc tat gac cgt     2726
Gln Gln Gly Gln Thr Asp Trp Pro Ala Val Lys Ser Phe Tyr Asp Arg         
    750                 755                 760                         

atc aag ctc ttg gca ggc aag gat agc acc cac atc att cct gga gag     2774
Ile Lys Leu Leu Ala Gly Lys Asp Ser Thr His Ile Ile Pro Gly Glu         
765                 770                 775                 780         

aac cct ttc aac agc agc ttg gtt tct ctc atc cga ggc caa gta gta     2822
Asn Pro Phe Asn Ser Ser Leu Val Ser Leu Ile Arg Gly Gln Val Val         
                785                 790                 795             

act aca gat gga act ccc ctg gtc ggt gtg aac gtg tct ttt gtc aag     2870
Thr Thr Asp Gly Thr Pro Leu Val Gly Val Asn Val Ser Phe Val Lys         
            800                 805                 810                 

tac cca aaa tac ggc tac acc atc acc cgc cag gat ggc acg ttc gac     2918
Tyr Pro Lys Tyr Gly Tyr Thr Ile Thr Arg Gln Asp Gly Thr Phe Asp         
        815                 820                 825                     

ctg atc gca aat gga ggt gct tcc ttg act cta cac ttt gag cga gcc     2966
Leu Ile Ala Asn Gly Gly Ala Ser Leu Thr Leu His Phe Glu Arg Ala         
    830                 835                 840                         

ccg ttc atg agc cag gag cgc act gtg tgg ctg ccg tgg aac agc ttt     3014
Pro Phe Met Ser Gln Glu Arg Thr Val Trp Leu Pro Trp Asn Ser Phe         
845                 850                 855                 860         

tac gcc atg gac acc ctg gtg atg aag acc gag gag aac tcc atc ccc     3062
Tyr Ala Met Asp Thr Leu Val Met Lys Thr Glu Glu Asn Ser Ile Pro         
                865                 870                 875             

agc tgt gac ctc agt ggc ttt gtc cgg cct gat cca atc atc atc tcc     3110
Ser Cys Asp Leu Ser Gly Phe Val Arg Pro Asp Pro Ile Ile Ile Ser         
            880                 885                 890                 

tcc cca ctg tcc acc ttc ttt agt gct gcc cct ggg cag aat ccc atc     3158
Ser Pro Leu Ser Thr Phe Phe Ser Ala Ala Pro Gly Gln Asn Pro Ile         
        895                 900                 905                     

gtg cct gag acc cag gtt ctt cat gaa gaa atc gag ctc cct ggt tcc     3206
Val Pro Glu Thr Gln Val Leu His Glu Glu Ile Glu Leu Pro Gly Ser         
    910                 915                 920                         

aat gtg aaa ctt cgc tat ctg agc tct aga act gca ggg tac aag tca     3254
Asn Val Lys Leu Arg Tyr Leu Ser Ser Arg Thr Ala Gly Tyr Lys Ser         
925                 930                 935                 940         

ctg ctg aag atc acc atg acc cag tcc aca gtg ccc ctg aac ctc att     3302
Leu Leu Lys Ile Thr Met Thr Gln Ser Thr Val Pro Leu Asn Leu Ile         
                945                 950                 955             

agg gtt cac ctg atg gtg gct gtc gag ggg cat ctc ttc cag aag tca     3350
Arg Val His Leu Met Val Ala Val Glu Gly His Leu Phe Gln Lys Ser         
            960                 965                 970                 

ttc cag gct tct ccc aac ctg gcc tac acc ttc atc tgg gac aag aca     3398
Phe Gln Ala Ser Pro Asn Leu Ala Tyr Thr Phe Ile Trp Asp Lys Thr         
        975                 980                 985                     

gat gcg tat ggc caa agg gtg tat gga ctc tca gat  gct gtt gtg tct    3446
Asp Ala Tyr Gly Gln Arg Val Tyr Gly Leu Ser Asp  Ala Val Val Ser        
    990                 995                 1000                        

gtc  ggg ttt gaa tat gag  acc tgt ccc agt cta  att ctc tgg gag      3491
Val  Gly Phe Glu Tyr Glu  Thr Cys Pro Ser Leu  Ile Leu Trp Glu          
1005                 1010                 1015                          

aaa  agg aca gcc ctc ctt  cag gga ttc gag ctg  gac ccc tcc aac      3536
Lys  Arg Thr Ala Leu Leu  Gln Gly Phe Glu Leu  Asp Pro Ser Asn          
1020                 1025                 1030                          

ctc  ggt ggc tgg tcc cta  gac aaa cac cac atc  ctc aat gtt aaa      3581
Leu  Gly Gly Trp Ser Leu  Asp Lys His His Ile  Leu Asn Val Lys          
1035                 1040                 1045                          

agt  gga atc cta cac aaa  ggc act ggg gaa aac  cag ttc ctg acc      3626
Ser  Gly Ile Leu His Lys  Gly Thr Gly Glu Asn  Gln Phe Leu Thr          
1050                 1055                 1060                          

cag  cag cct gcc atc atc  acc agc atc atg ggc  aat ggt cgc cgc      3671
Gln  Gln Pro Ala Ile Ile  Thr Ser Ile Met Gly  Asn Gly Arg Arg          
1065                 1070                 1075                          

cgg  agc att tcc tgt ccc  agc tgc aac ggc ctt  gct gaa ggc aac      3716
Arg  Ser Ile Ser Cys Pro  Ser Cys Asn Gly Leu  Ala Glu Gly Asn          
1080                 1085                 1090                          

aag  ctg ctg gcc cca gtg  gct ctg gct gtt gga  atc gat ggg agc      3761
Lys  Leu Leu Ala Pro Val  Ala Leu Ala Val Gly  Ile Asp Gly Ser          
1095                 1100                 1105                          

ctc  tat gtg ggt gac ttc  aat tac atc cga cgc  atc ttt ccc tct      3806
Leu  Tyr Val Gly Asp Phe  Asn Tyr Ile Arg Arg  Ile Phe Pro Ser          
1110                 1115                 1120                          

cga  aat gtg acc agc atc  ttg gag tta cga aat  aaa gag ttt aaa      3851
Arg  Asn Val Thr Ser Ile  Leu Glu Leu Arg Asn  Lys Glu Phe Lys          
1125                 1130                 1135                          

cat  agc aac aac cca gca  cac aag tac tac ttg  gca gtg gac ccc      3896
His  Ser Asn Asn Pro Ala  His Lys Tyr Tyr Leu  Ala Val Asp Pro          
1140                 1145                 1150                          

gtg  tcc ggc tcg ctc tac  gtg tcc gac acc aac  agc agg aga atc      3941
Val  Ser Gly Ser Leu Tyr  Val Ser Asp Thr Asn  Ser Arg Arg Ile          
1155                 1160                 1165                          

tac  cgc gtc aag tct ctg  agt gga acc aaa gac  ctg gct ggg aat      3986
Tyr  Arg Val Lys Ser Leu  Ser Gly Thr Lys Asp  Leu Ala Gly Asn          
1170                 1175                 1180                          

tcg  gaa gtt gtg gca ggg  acg gga gag cag tgt  cta ccc ttt gat      4031
Ser  Glu Val Val Ala Gly  Thr Gly Glu Gln Cys  Leu Pro Phe Asp          
1185                 1190                 1195                          

gaa  gcc cgc tgc ggg gat  gga ggg aag gcc ata  gat gca acc ctg      4076
Glu  Ala Arg Cys Gly Asp  Gly Gly Lys Ala Ile  Asp Ala Thr Leu          
1200                 1205                 1210                          

atg  agc ccg aga ggt att  gca gta gac aag aat  ggg ctc atg tac      4121
Met  Ser Pro Arg Gly Ile  Ala Val Asp Lys Asn  Gly Leu Met Tyr          
1215                 1220                 1225                          

ttt  gtc gat gcc acc atg  atc cgg aag gtt gac  cag aat gga atc      4166
Phe  Val Asp Ala Thr Met  Ile Arg Lys Val Asp  Gln Asn Gly Ile          
1230                 1235                 1240                          

atc  tcc acc ctg ctg ggc  tcc aat gac ctc act  gcc gtc cgg ccg      4211
Ile  Ser Thr Leu Leu Gly  Ser Asn Asp Leu Thr  Ala Val Arg Pro          
1245                 1250                 1255                          

ctg  agc tgt gat tcc agc  atg gat gta gcc cag  gtt cgt ctg gag      4256
Leu  Ser Cys Asp Ser Ser  Met Asp Val Ala Gln  Val Arg Leu Glu          
1260                 1265                 1270                          

tgg  cca aca gac ctt gct  gtc aat ccc atg gat  aac tcc ttg tat      4301
Trp  Pro Thr Asp Leu Ala  Val Asn Pro Met Asp  Asn Ser Leu Tyr          
1275                 1280                 1285                          

gtt  cta gag aac aat gtc  atc ctt cga atc acc  gag aac cac caa      4346
Val  Leu Glu Asn Asn Val  Ile Leu Arg Ile Thr  Glu Asn His Gln          
1290                 1295                 1300                          

gtc  agc atc att gcg gga  cgc ccc atg cac tgc  caa gtt cct ggc      4391
Val  Ser Ile Ile Ala Gly  Arg Pro Met His Cys  Gln Val Pro Gly          
1305                 1310                 1315                          

att  gac tac tca ctc agc  aaa cta gcc att cac  tct gcc ctg gag      4436
Ile  Asp Tyr Ser Leu Ser  Lys Leu Ala Ile His  Ser Ala Leu Glu          
1320                 1325                 1330                          

tca  gcc agt gcc att gcc  att tct cac act ggg  gtc ctc tac atc      4481
Ser  Ala Ser Ala Ile Ala  Ile Ser His Thr Gly  Val Leu Tyr Ile          
1335                 1340                 1345                          

act  gag aca gat gag aag  aag att aac cgt cta  cgc cag gta aca      4526
Thr  Glu Thr Asp Glu Lys  Lys Ile Asn Arg Leu  Arg Gln Val Thr          
1350                 1355                 1360                          

acc  aac ggg gag atc tgc  ctt tta gct ggg gca  gcc tcg gac tgc      4571
Thr  Asn Gly Glu Ile Cys  Leu Leu Ala Gly Ala  Ala Ser Asp Cys          
1365                 1370                 1375                          

gac  tgc aaa aac gat gtc  aat tgc aac tgc tat  tca gga gat gat      4616
Asp  Cys Lys Asn Asp Val  Asn Cys Asn Cys Tyr  Ser Gly Asp Asp          
1380                 1385                 1390                          

gcc  tac gcg act gat gcc  atc ttg aat tcc cca  tca tcc tta gct      4661
Ala  Tyr Ala Thr Asp Ala  Ile Leu Asn Ser Pro  Ser Ser Leu Ala          
1395                 1400                 1405                          

gta  gct cca gat ggt acc  att tac att gca gac  ctt gga aat att      4706
Val  Ala Pro Asp Gly Thr  Ile Tyr Ile Ala Asp  Leu Gly Asn Ile          
1410                 1415                 1420                          

cgg  atc agg gcg gtc agc  aag aac aag cct gtt  ctt aat gcc ttc      4751
Arg  Ile Arg Ala Val Ser  Lys Asn Lys Pro Val  Leu Asn Ala Phe          
1425                 1430                 1435                          

aac  cag tat gag gct gca  tcc ccc gga gag cag  gag tta tat gtt      4796
Asn  Gln Tyr Glu Ala Ala  Ser Pro Gly Glu Gln  Glu Leu Tyr Val          
1440                 1445                 1450                          

ttc  aac gct gat ggc atc  cac caa tac act gtg  agc ctg gtg aca      4841
Phe  Asn Ala Asp Gly Ile  His Gln Tyr Thr Val  Ser Leu Val Thr          
1455                 1460                 1465                          

ggg  gag tac ttg tac aat  ttc aca tat agt act  gac aat gat gtc      4886
Gly  Glu Tyr Leu Tyr Asn  Phe Thr Tyr Ser Thr  Asp Asn Asp Val          
1470                 1475                 1480                          

act  gaa ttg att gac aat  aat ggg aat tcc ctg  aag atc cgt cgg      4931
Thr  Glu Leu Ile Asp Asn  Asn Gly Asn Ser Leu  Lys Ile Arg Arg          
1485                 1490                 1495                          

gac  agc agt ggc atg ccc  cgt cac ctg ctc atg  cct gac aac cag      4976
Asp  Ser Ser Gly Met Pro  Arg His Leu Leu Met  Pro Asp Asn Gln          
1500                 1505                 1510                          

atc  atc acc ctc acc gtg  ggc acc aat gga ggc  ctc aaa gtc gtg      5021
Ile  Ile Thr Leu Thr Val  Gly Thr Asn Gly Gly  Leu Lys Val Val          
1515                 1520                 1525                          

tcc  aca cag aac ctg gag  ctt ggt ctc atg acc  tat gat ggc aac      5066
Ser  Thr Gln Asn Leu Glu  Leu Gly Leu Met Thr  Tyr Asp Gly Asn          
1530                 1535                 1540                          

act  ggg ctc ctg gcc acc  aag agc gat gaa aca  gga tgg acg act      5111
Thr  Gly Leu Leu Ala Thr  Lys Ser Asp Glu Thr  Gly Trp Thr Thr          
1545                 1550                 1555                          

ttc  tat gac tat gac cac  gaa ggc cgc ctg acc  aac gtg acg cgc      5156
Phe  Tyr Asp Tyr Asp His  Glu Gly Arg Leu Thr  Asn Val Thr Arg          
1560                 1565                 1570                          

ccc  acg ggg gtg gta acc  agt ctg cac cgg gaa  atg gag aaa tct      5201
Pro  Thr Gly Val Val Thr  Ser Leu His Arg Glu  Met Glu Lys Ser          
1575                 1580                 1585                          

att  acc att gac att gag  aac tcc aac cgt gat  gat gac gtc act      5246
Ile  Thr Ile Asp Ile Glu  Asn Ser Asn Arg Asp  Asp Asp Val Thr          
1590                 1595                 1600                          

gtc  atc acc aac ctc tct  tca gta gag gcc tcc  tac aca gtg gta      5291
Val  Ile Thr Asn Leu Ser  Ser Val Glu Ala Ser  Tyr Thr Val Val          
1605                 1610                 1615                          

caa  gat caa gtt cgg aac  agc tac cag ctc tgt  aat aat ggt acc      5336
Gln  Asp Gln Val Arg Asn  Ser Tyr Gln Leu Cys  Asn Asn Gly Thr          
1620                 1625                 1630                          

ctg  agg gtg atg tat gct  aat ggg atg ggt atc  agc ttc cac agc      5381
Leu  Arg Val Met Tyr Ala  Asn Gly Met Gly Ile  Ser Phe His Ser          
1635                 1640                 1645                          

gag  ccc cat gtc cta gcg  ggc acc atc acc ccc  acc att gga cgc      5426
Glu  Pro His Val Leu Ala  Gly Thr Ile Thr Pro  Thr Ile Gly Arg          
1650                 1655                 1660                          

tgc  aac atc tcc ctg cct  atg gag aat ggc tta  aac tcc att gag      5471
Cys  Asn Ile Ser Leu Pro  Met Glu Asn Gly Leu  Asn Ser Ile Glu          
1665                 1670                 1675                          

tgg  cgc cta aga aag gaa  cag att aaa ggc aaa  gtc acc atc ttt      5516
Trp  Arg Leu Arg Lys Glu  Gln Ile Lys Gly Lys  Val Thr Ile Phe          
1680                 1685                 1690                          

ggc  agg aag ctc cgg gtc  cat gga aga aat ctc  ttg tcc att gac      5561
Gly  Arg Lys Leu Arg Val  His Gly Arg Asn Leu  Leu Ser Ile Asp          
1695                 1700                 1705                          

tat  gat cga aat att cgg  act gaa aag atc tat  gat gac cac cgg      5606
Tyr  Asp Arg Asn Ile Arg  Thr Glu Lys Ile Tyr  Asp Asp His Arg          
1710                 1715                 1720                          

aag  ttc acc ctg agg atc  att tat gac cag gtg  ggc cgc ccc ttc      5651
Lys  Phe Thr Leu Arg Ile  Ile Tyr Asp Gln Val  Gly Arg Pro Phe          
1725                 1730                 1735                          

ctc  tgg ctg ccc agc agc  ggg ctg gca gct gtc  aac gtg tca tac      5696
Leu  Trp Leu Pro Ser Ser  Gly Leu Ala Ala Val  Asn Val Ser Tyr          
1740                 1745                 1750                          

ttc  ttc aat ggg cgc ctg  gct ggg ctt cag cgt  ggg gcc atg agc      5741
Phe  Phe Asn Gly Arg Leu  Ala Gly Leu Gln Arg  Gly Ala Met Ser          
1755                 1760                 1765                          

gag  agg aca gac atc gac  aag caa ggc cgc atc  gtg tcc cgc atg      5786
Glu  Arg Thr Asp Ile Asp  Lys Gln Gly Arg Ile  Val Ser Arg Met          
1770                 1775                 1780                          

ttc  gct gac ggg aaa gtg  tgg agc tac tcc tac  ctt gac aag tcc      5831
Phe  Ala Asp Gly Lys Val  Trp Ser Tyr Ser Tyr  Leu Asp Lys Ser          
1785                 1790                 1795                          

atg  gtc ctc ctg ctt cag  agc caa cgt cag tat  ata ttt gag tat      5876
Met  Val Leu Leu Leu Gln  Ser Gln Arg Gln Tyr  Ile Phe Glu Tyr          
1800                 1805                 1810                          

gac  tcc tct gac cgc ctc  ctt gcc gtc acc atg  ccc agc gtg gcc      5921
Asp  Ser Ser Asp Arg Leu  Leu Ala Val Thr Met  Pro Ser Val Ala          
1815                 1820                 1825                          

cgg  cac agc atg tcc aca  cac acc tcc atc ggc  tac atc cgt aat      5966
Arg  His Ser Met Ser Thr  His Thr Ser Ile Gly  Tyr Ile Arg Asn          
1830                 1835                 1840                          

att  tac aac ccg cct gaa  agc aat gct tcg gtc  atc ttt gac tac      6011
Ile  Tyr Asn Pro Pro Glu  Ser Asn Ala Ser Val  Ile Phe Asp Tyr          
1845                 1850                 1855                          

agt  gat gac ggc cgc atc  ctg aag acc tcc ttt  ttg ggc acc gga      6056
Ser  Asp Asp Gly Arg Ile  Leu Lys Thr Ser Phe  Leu Gly Thr Gly          
1860                 1865                 1870                          

cgc  cag gtg ttc tac aag  tat ggg aaa ctc tcc  aag tta tca gag      6101
Arg  Gln Val Phe Tyr Lys  Tyr Gly Lys Leu Ser  Lys Leu Ser Glu          
1875                 1880                 1885                          

att  gtc tac gac agt acc  gcc gtc acc ttc ggg  tat gac gag acc      6146
Ile  Val Tyr Asp Ser Thr  Ala Val Thr Phe Gly  Tyr Asp Glu Thr          
1890                 1895                 1900                          

act  ggt gtc ttg aag atg  gtc aac ctc caa agt  ggg ggc ttc tcc      6191
Thr  Gly Val Leu Lys Met  Val Asn Leu Gln Ser  Gly Gly Phe Ser          
1905                 1910                 1915                          

tgc  acc atc agg tac cgg  aag att ggc ccc ctg  gtg gac aag cag      6236
Cys  Thr Ile Arg Tyr Arg  Lys Ile Gly Pro Leu  Val Asp Lys Gln          
1920                 1925                 1930                          

atc  tac agg ttc tcc gag  gaa ggc atg gtc aat  gcc agg ttt gac      6281
Ile  Tyr Arg Phe Ser Glu  Glu Gly Met Val Asn  Ala Arg Phe Asp          
1935                 1940                 1945                          

tac  acc tat cat gac aac  agc ttc cgc atc gca  agc atc aag ccc      6326
Tyr  Thr Tyr His Asp Asn  Ser Phe Arg Ile Ala  Ser Ile Lys Pro          
1950                 1955                 1960                          

gtc  ata agt gag act ccc  ctc ccc gtt gac ctc  tac cgc tat gat      6371
Val  Ile Ser Glu Thr Pro  Leu Pro Val Asp Leu  Tyr Arg Tyr Asp          
1965                 1970                 1975                          

gag  att tct ggc aag gtg  gaa cac ttt ggt aag  ttt gga gtc atc      6416
Glu  Ile Ser Gly Lys Val  Glu His Phe Gly Lys  Phe Gly Val Ile          
1980                 1985                 1990                          

tat  tat gac atc aac cag  atc atc acc act gcc  gtg atg acc ctc      6461
Tyr  Tyr Asp Ile Asn Gln  Ile Ile Thr Thr Ala  Val Met Thr Leu          
1995                 2000                 2005                          

agc  aaa cac ttc gac acc  cat ggg cgg atc aag  gag gtc cag tat      6506
Ser  Lys His Phe Asp Thr  His Gly Arg Ile Lys  Glu Val Gln Tyr          
2010                 2015                 2020                          

gag  atg ttc cgg tcc ctc  atg tac tgg atg acg  gtg caa tat gac      6551
Glu  Met Phe Arg Ser Leu  Met Tyr Trp Met Thr  Val Gln Tyr Asp          
2025                 2030                 2035                          

agc  atg ggc agg gtg atc  aag agg gag cta aaa  ctg ggg ccc tat      6596
Ser  Met Gly Arg Val Ile  Lys Arg Glu Leu Lys  Leu Gly Pro Tyr          
2040                 2045                 2050                          

gcc  aat acc acg aag tac  acc tat gac tac gat  ggg gac ggg cag      6641
Ala  Asn Thr Thr Lys Tyr  Thr Tyr Asp Tyr Asp  Gly Asp Gly Gln          
2055                 2060                 2065                          

ctc  cag agc gtg gcc gtc  aat gac cgc ccg acc  tgg cgc tac agc      6686
Leu  Gln Ser Val Ala Val  Asn Asp Arg Pro Thr  Trp Arg Tyr Ser          
2070                 2075                 2080                          

tat  gac ctt aat ggg aat  ctc cac tta ctg aac  cca ggc aac agt      6731
Tyr  Asp Leu Asn Gly Asn  Leu His Leu Leu Asn  Pro Gly Asn Ser          
2085                 2090                 2095                          

gtg  cgc ctc atg ccc ttg  cgc tat gac ctc cgg  gat cgg ata acc      6776
Val  Arg Leu Met Pro Leu  Arg Tyr Asp Leu Arg  Asp Arg Ile Thr          
2100                 2105                 2110                          

aga  ctc ggg gat gtg cag  tac aaa att gac gac  gat ggc tat ctg      6821
Arg  Leu Gly Asp Val Gln  Tyr Lys Ile Asp Asp  Asp Gly Tyr Leu          
2115                 2120                 2125                          

tgc  cag aga ggg tct gac  atc ttc gaa tac aat  tcc aag ggc ctc      6866
Cys  Gln Arg Gly Ser Asp  Ile Phe Glu Tyr Asn  Ser Lys Gly Leu          
2130                 2135                 2140                          

cta  aca aga gcc tac aac  aag gcc agc ggg tgg  agt gtc cag tac      6911
Leu  Thr Arg Ala Tyr Asn  Lys Ala Ser Gly Trp  Ser Val Gln Tyr          
2145                 2150                 2155                          

cgc  tat gat ggc gta gga  cgg cgg gct tcc tac  aag acc aac ctg      6956
Arg  Tyr Asp Gly Val Gly  Arg Arg Ala Ser Tyr  Lys Thr Asn Leu          
2160                 2165                 2170                          

ggc  cac cac ctg cag tac  ttc tac tct gac ctc  cac aac ccg acg      7001
Gly  His His Leu Gln Tyr  Phe Tyr Ser Asp Leu  His Asn Pro Thr          
2175                 2180                 2185                          

cgc  atc acc cat gtc tac  aat cac tcc aac tcg  gag att acc tca      7046
Arg  Ile Thr His Val Tyr  Asn His Ser Asn Ser  Glu Ile Thr Ser          
2190                 2195                 2200                          

ctg  tac tac gac ctc cag  ggc cac ctc ttt gcc  atg gag agc agc      7091
Leu  Tyr Tyr Asp Leu Gln  Gly His Leu Phe Ala  Met Glu Ser Ser          
2205                 2210                 2215                          

agt  ggg gag gag tac tat  gtt gcc tct gat aac  aca ggg act cct      7136
Ser  Gly Glu Glu Tyr Tyr  Val Ala Ser Asp Asn  Thr Gly Thr Pro          
2220                 2225                 2230                          

ctg  gct gtg ttc agc atc  aac ggc ctc atg atc  aaa cag ctg cag      7181
Leu  Ala Val Phe Ser Ile  Asn Gly Leu Met Ile  Lys Gln Leu Gln          
2235                 2240                 2245                          

tac  acg gcc tat ggg gag  att tat tat gac tcc  aac ccc gac ttc      7226
Tyr  Thr Ala Tyr Gly Glu  Ile Tyr Tyr Asp Ser  Asn Pro Asp Phe          
2250                 2255                 2260                          

cag  atg gtc att ggc ttc  cat ggg gga ctc tat  gac ccc ctg acc      7271
Gln  Met Val Ile Gly Phe  His Gly Gly Leu Tyr  Asp Pro Leu Thr          
2265                 2270                 2275                          

aag  ctg gtc cac ttc act  cag cgt gat tat gat  gtg ctg gca gga      7316
Lys  Leu Val His Phe Thr  Gln Arg Asp Tyr Asp  Val Leu Ala Gly          
2280                 2285                 2290                          

cga  tgg acc tcc cca gac  tat acc atg tgg aaa  aac gtg ggc aag      7361
Arg  Trp Thr Ser Pro Asp  Tyr Thr Met Trp Lys  Asn Val Gly Lys          
2295                 2300                 2305                          

gag  ccg gcc ccc ttt aac  ctg tat atg ttc aag  agc aac aat cct      7406
Glu  Pro Ala Pro Phe Asn  Leu Tyr Met Phe Lys  Ser Asn Asn Pro          
2310                 2315                 2320                          

ctc  agc agt gag cta gat  ttg aag aac tac gtg  aca gat gtg aaa      7451
Leu  Ser Ser Glu Leu Asp  Leu Lys Asn Tyr Val  Thr Asp Val Lys          
2325                 2330                 2335                          

agc  tgg ctt gtg atg ttt  gga ttt cag ctt agc  aac atc att cct      7496
Ser  Trp Leu Val Met Phe  Gly Phe Gln Leu Ser  Asn Ile Ile Pro          
2340                 2345                 2350                          

ggc  ttc ccg aga gcc aaa  atg tat ttc gtg cct  cct ccc tat gaa      7541
Gly  Phe Pro Arg Ala Lys  Met Tyr Phe Val Pro  Pro Pro Tyr Glu          
2355                 2360                 2365                          

ttg  tca gag agt caa gca  agt gag aat gga cag  ctc att aca ggt      7586
Leu  Ser Glu Ser Gln Ala  Ser Glu Asn Gly Gln  Leu Ile Thr Gly          
2370                 2375                 2380                          

gtc  caa cag aca aca gag  aga cat aac cag gcc  ttc atg gct ctg      7631
Val  Gln Gln Thr Thr Glu  Arg His Asn Gln Ala  Phe Met Ala Leu          
2385                 2390                 2395                          

gaa  gga cag gtc att act  aaa aag ctc cac gcc  agc atc cga gag      7676
Glu  Gly Gln Val Ile Thr  Lys Lys Leu His Ala  Ser Ile Arg Glu          
2400                 2405                 2410                          

aaa  gca ggt cac tgg ttt  gcc acc acc acg ccc  atc att ggc aaa      7721
Lys  Ala Gly His Trp Phe  Ala Thr Thr Thr Pro  Ile Ile Gly Lys          
2415                 2420                 2425                          

ggc  atc atg ttt gcc atc  aaa gaa ggg cgg gtg  acc acg ggc gtg      7766
Gly  Ile Met Phe Ala Ile  Lys Glu Gly Arg Val  Thr Thr Gly Val          
2430                 2435                 2440                          

tcc  agc atc gcc agc gaa  gat agc cgc aag gtg  gca tct gtg ctg      7811
Ser  Ser Ile Ala Ser Glu  Asp Ser Arg Lys Val  Ala Ser Val Leu          
2445                 2450                 2455                          

aac  aac gcc tac tac ctg  gac aag atg cac tac  agc atc gag ggc      7856
Asn  Asn Ala Tyr Tyr Leu  Asp Lys Met His Tyr  Ser Ile Glu Gly          
2460                 2465                 2470                          

aag  gac acc cac tac ttt  gtg aag att ggc tca  gcc gat ggc gac      7901
Lys  Asp Thr His Tyr Phe  Val Lys Ile Gly Ser  Ala Asp Gly Asp          
2475                 2480                 2485                          

ctg  gtc aca cta ggc acc  acc atc ggc cgc aag  gtg cta gag agc      7946
Leu  Val Thr Leu Gly Thr  Thr Ile Gly Arg Lys  Val Leu Glu Ser          
2490                 2495                 2500                          

ggg  gtg aac gtg acc gtg  tcc cag ccc acg ctg  ctg gtc aac ggc      7991
Gly  Val Asn Val Thr Val  Ser Gln Pro Thr Leu  Leu Val Asn Gly          
2505                 2510                 2515                          

agg  act cga agg ttc acg  aac att gag ttc cag  tac tcc acg ctg      8036
Arg  Thr Arg Arg Phe Thr  Asn Ile Glu Phe Gln  Tyr Ser Thr Leu          
2520                 2525                 2530                          

ctg  ctc agc atc cgc tat  ggc ctc acc ccc gac  acc ctg gac gaa      8081
Leu  Leu Ser Ile Arg Tyr  Gly Leu Thr Pro Asp  Thr Leu Asp Glu          
2535                 2540                 2545                          

gag  aag gcc cgc gtc ctg  gac cag gcg aga cag  agg gcc ctg ggc      8126
Glu  Lys Ala Arg Val Leu  Asp Gln Ala Arg Gln  Arg Ala Leu Gly          
2550                 2555                 2560                          

acg  gcc tgg gcc aag gag  cag cag aaa gcc agg  gac ggg aga gag      8171
Thr  Ala Trp Ala Lys Glu  Gln Gln Lys Ala Arg  Asp Gly Arg Glu          
2565                 2570                 2575                          

ggg  agc cgc ctg tgg act  gag ggc gag aag cag  cag ctt ctg agc      8216
Gly  Ser Arg Leu Trp Thr  Glu Gly Glu Lys Gln  Gln Leu Leu Ser          
2580                 2585                 2590                          

acc  ggg cgc gtg caa ggg  tac gag gga tat tac  gtg ctt ccc gtg      8261
Thr  Gly Arg Val Gln Gly  Tyr Glu Gly Tyr Tyr  Val Leu Pro Val          
2595                 2600                 2605                          

gag  caa tac cca gag ctt  gca gac agt agc agc  aac atc cag ttt      8306
Glu  Gln Tyr Pro Glu Leu  Ala Asp Ser Ser Ser  Asn Ile Gln Phe          
2610                 2615                 2620                          

tta  aga cag aat gag atg  gga aag agg taa caaaataatc tgctgccatt     8356
Leu  Arg Gln Asn Glu Met  Gly Lys Arg                                   
2625                 2630                                               

ccttgtctga atggctcagc aggagtaact gttatctcct ctcctaagga gatgaagacc   8416

taacaggggc actgcggctg ggctgcttta ggagaccaag tggcaagaaa gctcacattt   8476

tttgagttca aatgctactg tccaagcgag aagtccctca tcctgaagta gactaaagcc   8536

cggctgaaaa ttccgaggaa aacaaaacaa acgaatgaat gaacagacac acacaatgtt   8596

ccaagttccc ctaaaatatg acccacttgt tctgggtcta cgcagaaaag agacgcaaag   8656

tgtccaaaag gaacaaaaga acaaaaacga ataagcaaag aagaaaacaa acaaaaacaa   8716

aacaaaacaa acacacggac cgataaacaa agaagcgaag ataagaaaga aggcctcata   8776

tccaattacc tcactcattc acatgtgagc gacacgcaga catccgcgag ggccagcgtc   8836

accagaccag ctgcgggaca aaccactcag actgcttgta ggacaaatac ttctgacatt   8896

ttcgtttaag caaatacagg tgcatttaaa acacgacttt gggggtgatt tgtgtgtagc   8956

gcctggggag gggggataaa agaggaggag tgagcactgg aaatactttt taaagaaaaa   9016

aaaacatgag ggaataaaag aaattcctat caaaaatcaa agtgaaataa taccatccag   9076

cacttaactc tcaggtccca actaagtctg gcctgagcta atttatttga gcgcagagtg   9136

taaaatttaa ttcaaaatgg tggctataat cactacagat aaatttcata ctcttttgtc   9196

tttggagatt ccattgtgga cagtaatacg cagttacagg gtgtagtctg tttagattcc   9256

gtagttcgtg ggtatcagtt tcggtagagg tgcagcatcg tgacactttt gctaacaggt   9316

accacttctg atcaccctgt acatacatga gccgaaaggc acaatcactg tttcagattt   9376

aaaattatta gtgtgtttgt ttggtccaga aactgagaca atcacatgac agtcaccacg   9436

aggagagaaa atttaaaaaa taaaaataaa aacaaaaaaa attttaaaaa ttaaaaaaac   9496

aaaaataaag tctaataaga actttggtac aggaactttt ttgtaatata catgtatgaa   9556

ttgttcatcg agtttttata ttaattttaa tttgctgcta agcaaagact agggacaggc   9616

aaagataatt tatggcaaag tgtttaaatt gtttatacat gaataaagtc tctaaaactc   9676

caaaaaaaaa aaaaaaaaa                                                9695


<210>  82
<211>  2633
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Asp Val Lys Asp Arg Arg His Arg Ser Leu Thr Arg Gly Arg Cys 
1               5                   10                  15      


Gly Lys Glu Cys Arg Tyr Thr Ser Ser Ser Leu Asp Ser Glu Asp Cys 
            20                  25                  30          


Arg Val Pro Thr Gln Lys Ser Tyr Ser Ser Ser Glu Thr Leu Lys Ala 
        35                  40                  45              


Tyr Asp His Asp Ser Arg Met His Tyr Gly Asn Arg Val Thr Asp Leu 
    50                  55                  60                  


Ile His Arg Glu Ser Asp Glu Phe Pro Arg Gln Gly Thr Asn Phe Thr 
65                  70                  75                  80  


Leu Ala Glu Leu Gly Ile Cys Glu Pro Ser Pro His Arg Ser Gly Tyr 
                85                  90                  95      


Cys Ser Asp Met Gly Ile Leu His Gln Gly Tyr Ser Leu Ser Thr Gly 
            100                 105                 110         


Ser Asp Ala Asp Ser Asp Thr Glu Gly Gly Met Ser Pro Glu His Ala 
        115                 120                 125             


Ile Arg Leu Trp Gly Arg Gly Ile Lys Ser Arg Arg Ser Ser Gly Leu 
    130                 135                 140                 


Ser Ser Arg Glu Asn Ser Ala Leu Thr Leu Thr Asp Ser Asp Asn Glu 
145                 150                 155                 160 


Asn Lys Ser Asp Asp Glu Asn Gly Pro Pro Asn His His Ser Gln Ser 
                165                 170                 175     


Thr Leu Arg Pro Pro Leu Pro Pro Pro His Asn His Thr Leu Ser His 
            180                 185                 190         


His His Ser Ser Ala Asn Ser Leu Asn Arg Asn Ser Leu Thr Asn Arg 
        195                 200                 205             


Arg Ser Gln Ile His Ala Pro Ala Pro Ala Pro Asn Asp Leu Ala Thr 
    210                 215                 220                 


Thr Pro Glu Ser Val Gln Leu Gln Asp Ser Trp Val Leu Asn Ser Asn 
225                 230                 235                 240 


Val Pro Leu Glu Thr Arg His Phe Leu Phe Lys Thr Ser Ser Gly Ser 
                245                 250                 255     


Thr Pro Leu Phe Ser Ser Ser Ser Pro Gly Tyr Pro Leu Thr Ser Gly 
            260                 265                 270         


Thr Val Tyr Thr Pro Pro Pro Arg Leu Leu Pro Arg Asn Thr Phe Ser 
        275                 280                 285             


Arg Lys Ala Phe Lys Leu Lys Lys Pro Ser Lys Tyr Cys Ser Trp Lys 
    290                 295                 300                 


Cys Ala Ala Leu Ser Ala Ile Ala Ala Ala Leu Leu Leu Ala Ile Leu 
305                 310                 315                 320 


Leu Ala Tyr Phe Ile Ala Met His Leu Leu Gly Leu Asn Trp Gln Leu 
                325                 330                 335     


Gln Pro Ala Asp Gly His Thr Phe Asn Asn Gly Ile Arg Thr Gly Leu 
            340                 345                 350         


Pro Gly Asn Asp Asp Val Ala Thr Met Pro Ser Gly Gly Lys Val Pro 
        355                 360                 365             


Trp Ser Leu Lys Asn Ser Ser Ile Asp Ser Gly Glu Ala Glu Val Gly 
    370                 375                 380                 


Arg Arg Val Thr Gln Glu Val Pro Pro Gly Val Phe Trp Arg Ser Gln 
385                 390                 395                 400 


Ile His Ile Ser Gln Pro Gln Phe Leu Lys Phe Asn Ile Ser Leu Gly 
                405                 410                 415     


Lys Asp Ala Leu Phe Gly Val Tyr Ile Arg Arg Gly Leu Pro Pro Ser 
            420                 425                 430         


His Ala Gln Tyr Asp Phe Met Glu Arg Leu Asp Gly Lys Glu Lys Trp 
        435                 440                 445             


Ser Val Val Glu Ser Pro Arg Glu Arg Arg Ser Ile Gln Thr Leu Val 
    450                 455                 460                 


Gln Asn Glu Ala Val Phe Val Gln Tyr Leu Asp Val Gly Leu Trp His 
465                 470                 475                 480 


Leu Ala Phe Tyr Asn Asp Gly Lys Asp Lys Glu Met Val Ser Phe Asn 
                485                 490                 495     


Thr Val Val Leu Asp Ser Val Gln Asp Cys Pro Arg Asn Cys His Gly 
            500                 505                 510         


Asn Gly Glu Cys Val Ser Gly Val Cys His Cys Phe Pro Gly Phe Leu 
        515                 520                 525             


Gly Ala Asp Cys Ala Lys Ala Ala Cys Pro Val Leu Cys Ser Gly Asn 
    530                 535                 540                 


Gly Gln Tyr Ser Lys Gly Thr Cys Gln Cys Tyr Ser Gly Trp Lys Gly 
545                 550                 555                 560 


Ala Glu Cys Asp Val Pro Met Asn Gln Cys Ile Asp Pro Ser Cys Gly 
                565                 570                 575     


Gly His Gly Ser Cys Ile Asp Gly Asn Cys Val Cys Ser Ala Gly Tyr 
            580                 585                 590         


Lys Gly Glu His Cys Glu Glu Val Asp Cys Leu Asp Pro Thr Cys Ser 
        595                 600                 605             


Ser His Gly Val Cys Val Asn Gly Glu Cys Leu Cys Ser Pro Gly Trp 
    610                 615                 620                 


Gly Gly Leu Asn Cys Glu Leu Ala Arg Val Gln Cys Pro Asp Gln Cys 
625                 630                 635                 640 


Ser Gly His Gly Thr Tyr Leu Pro Asp Thr Gly Leu Cys Ser Cys Asp 
                645                 650                 655     


Pro Asn Trp Met Gly Pro Asp Cys Ser Val Asp Gly Cys Pro Asp Leu 
            660                 665                 670         


Cys Asn Gly Asn Gly Arg Cys Thr Leu Gly Gln Asn Ser Trp Gln Cys 
        675                 680                 685             


Val Cys Gln Thr Gly Trp Arg Gly Pro Gly Cys Asn Val Ala Met Glu 
    690                 695                 700                 


Thr Ser Cys Ala Asp Asn Lys Asp Asn Glu Gly Asp Gly Leu Val Asp 
705                 710                 715                 720 


Cys Leu Asp Pro Asp Cys Cys Leu Gln Ser Ala Cys Gln Asn Ser Leu 
                725                 730                 735     


Leu Cys Arg Gly Ser Arg Asp Pro Leu Asp Ile Ile Gln Gln Gly Gln 
            740                 745                 750         


Thr Asp Trp Pro Ala Val Lys Ser Phe Tyr Asp Arg Ile Lys Leu Leu 
        755                 760                 765             


Ala Gly Lys Asp Ser Thr His Ile Ile Pro Gly Glu Asn Pro Phe Asn 
    770                 775                 780                 


Ser Ser Leu Val Ser Leu Ile Arg Gly Gln Val Val Thr Thr Asp Gly 
785                 790                 795                 800 


Thr Pro Leu Val Gly Val Asn Val Ser Phe Val Lys Tyr Pro Lys Tyr 
                805                 810                 815     


Gly Tyr Thr Ile Thr Arg Gln Asp Gly Thr Phe Asp Leu Ile Ala Asn 
            820                 825                 830         


Gly Gly Ala Ser Leu Thr Leu His Phe Glu Arg Ala Pro Phe Met Ser 
        835                 840                 845             


Gln Glu Arg Thr Val Trp Leu Pro Trp Asn Ser Phe Tyr Ala Met Asp 
    850                 855                 860                 


Thr Leu Val Met Lys Thr Glu Glu Asn Ser Ile Pro Ser Cys Asp Leu 
865                 870                 875                 880 


Ser Gly Phe Val Arg Pro Asp Pro Ile Ile Ile Ser Ser Pro Leu Ser 
                885                 890                 895     


Thr Phe Phe Ser Ala Ala Pro Gly Gln Asn Pro Ile Val Pro Glu Thr 
            900                 905                 910         


Gln Val Leu His Glu Glu Ile Glu Leu Pro Gly Ser Asn Val Lys Leu 
        915                 920                 925             


Arg Tyr Leu Ser Ser Arg Thr Ala Gly Tyr Lys Ser Leu Leu Lys Ile 
    930                 935                 940                 


Thr Met Thr Gln Ser Thr Val Pro Leu Asn Leu Ile Arg Val His Leu 
945                 950                 955                 960 


Met Val Ala Val Glu Gly His Leu Phe Gln Lys Ser Phe Gln Ala Ser 
                965                 970                 975     


Pro Asn Leu Ala Tyr Thr Phe Ile Trp Asp Lys Thr Asp Ala Tyr Gly 
            980                 985                 990         


Gln Arg Val Tyr Gly Leu Ser Asp  Ala Val Val Ser Val  Gly Phe Glu 
        995                 1000                 1005             


Tyr Glu  Thr Cys Pro Ser Leu  Ile Leu Trp Glu Lys  Arg Thr Ala 
    1010                 1015                 1020             


Leu Leu  Gln Gly Phe Glu Leu  Asp Pro Ser Asn Leu  Gly Gly Trp 
    1025                 1030                 1035             


Ser Leu  Asp Lys His His Ile  Leu Asn Val Lys Ser  Gly Ile Leu 
    1040                 1045                 1050             


His Lys  Gly Thr Gly Glu Asn  Gln Phe Leu Thr Gln  Gln Pro Ala 
    1055                 1060                 1065             


Ile Ile  Thr Ser Ile Met Gly  Asn Gly Arg Arg Arg  Ser Ile Ser 
    1070                 1075                 1080             


Cys Pro  Ser Cys Asn Gly Leu  Ala Glu Gly Asn Lys  Leu Leu Ala 
    1085                 1090                 1095             


Pro Val  Ala Leu Ala Val Gly  Ile Asp Gly Ser Leu  Tyr Val Gly 
    1100                 1105                 1110             


Asp Phe  Asn Tyr Ile Arg Arg  Ile Phe Pro Ser Arg  Asn Val Thr 
    1115                 1120                 1125             


Ser Ile  Leu Glu Leu Arg Asn  Lys Glu Phe Lys His  Ser Asn Asn 
    1130                 1135                 1140             


Pro Ala  His Lys Tyr Tyr Leu  Ala Val Asp Pro Val  Ser Gly Ser 
    1145                 1150                 1155             


Leu Tyr  Val Ser Asp Thr Asn  Ser Arg Arg Ile Tyr  Arg Val Lys 
    1160                 1165                 1170             


Ser Leu  Ser Gly Thr Lys Asp  Leu Ala Gly Asn Ser  Glu Val Val 
    1175                 1180                 1185             


Ala Gly  Thr Gly Glu Gln Cys  Leu Pro Phe Asp Glu  Ala Arg Cys 
    1190                 1195                 1200             


Gly Asp  Gly Gly Lys Ala Ile  Asp Ala Thr Leu Met  Ser Pro Arg 
    1205                 1210                 1215             


Gly Ile  Ala Val Asp Lys Asn  Gly Leu Met Tyr Phe  Val Asp Ala 
    1220                 1225                 1230             


Thr Met  Ile Arg Lys Val Asp  Gln Asn Gly Ile Ile  Ser Thr Leu 
    1235                 1240                 1245             


Leu Gly  Ser Asn Asp Leu Thr  Ala Val Arg Pro Leu  Ser Cys Asp 
    1250                 1255                 1260             


Ser Ser  Met Asp Val Ala Gln  Val Arg Leu Glu Trp  Pro Thr Asp 
    1265                 1270                 1275             


Leu Ala  Val Asn Pro Met Asp  Asn Ser Leu Tyr Val  Leu Glu Asn 
    1280                 1285                 1290             


Asn Val  Ile Leu Arg Ile Thr  Glu Asn His Gln Val  Ser Ile Ile 
    1295                 1300                 1305             


Ala Gly  Arg Pro Met His Cys  Gln Val Pro Gly Ile  Asp Tyr Ser 
    1310                 1315                 1320             


Leu Ser  Lys Leu Ala Ile His  Ser Ala Leu Glu Ser  Ala Ser Ala 
    1325                 1330                 1335             


Ile Ala  Ile Ser His Thr Gly  Val Leu Tyr Ile Thr  Glu Thr Asp 
    1340                 1345                 1350             


Glu Lys  Lys Ile Asn Arg Leu  Arg Gln Val Thr Thr  Asn Gly Glu 
    1355                 1360                 1365             


Ile Cys  Leu Leu Ala Gly Ala  Ala Ser Asp Cys Asp  Cys Lys Asn 
    1370                 1375                 1380             


Asp Val  Asn Cys Asn Cys Tyr  Ser Gly Asp Asp Ala  Tyr Ala Thr 
    1385                 1390                 1395             


Asp Ala  Ile Leu Asn Ser Pro  Ser Ser Leu Ala Val  Ala Pro Asp 
    1400                 1405                 1410             


Gly Thr  Ile Tyr Ile Ala Asp  Leu Gly Asn Ile Arg  Ile Arg Ala 
    1415                 1420                 1425             


Val Ser  Lys Asn Lys Pro Val  Leu Asn Ala Phe Asn  Gln Tyr Glu 
    1430                 1435                 1440             


Ala Ala  Ser Pro Gly Glu Gln  Glu Leu Tyr Val Phe  Asn Ala Asp 
    1445                 1450                 1455             


Gly Ile  His Gln Tyr Thr Val  Ser Leu Val Thr Gly  Glu Tyr Leu 
    1460                 1465                 1470             


Tyr Asn  Phe Thr Tyr Ser Thr  Asp Asn Asp Val Thr  Glu Leu Ile 
    1475                 1480                 1485             


Asp Asn  Asn Gly Asn Ser Leu  Lys Ile Arg Arg Asp  Ser Ser Gly 
    1490                 1495                 1500             


Met Pro  Arg His Leu Leu Met  Pro Asp Asn Gln Ile  Ile Thr Leu 
    1505                 1510                 1515             


Thr Val  Gly Thr Asn Gly Gly  Leu Lys Val Val Ser  Thr Gln Asn 
    1520                 1525                 1530             


Leu Glu  Leu Gly Leu Met Thr  Tyr Asp Gly Asn Thr  Gly Leu Leu 
    1535                 1540                 1545             


Ala Thr  Lys Ser Asp Glu Thr  Gly Trp Thr Thr Phe  Tyr Asp Tyr 
    1550                 1555                 1560             


Asp His  Glu Gly Arg Leu Thr  Asn Val Thr Arg Pro  Thr Gly Val 
    1565                 1570                 1575             


Val Thr  Ser Leu His Arg Glu  Met Glu Lys Ser Ile  Thr Ile Asp 
    1580                 1585                 1590             


Ile Glu  Asn Ser Asn Arg Asp  Asp Asp Val Thr Val  Ile Thr Asn 
    1595                 1600                 1605             


Leu Ser  Ser Val Glu Ala Ser  Tyr Thr Val Val Gln  Asp Gln Val 
    1610                 1615                 1620             


Arg Asn  Ser Tyr Gln Leu Cys  Asn Asn Gly Thr Leu  Arg Val Met 
    1625                 1630                 1635             


Tyr Ala  Asn Gly Met Gly Ile  Ser Phe His Ser Glu  Pro His Val 
    1640                 1645                 1650             


Leu Ala  Gly Thr Ile Thr Pro  Thr Ile Gly Arg Cys  Asn Ile Ser 
    1655                 1660                 1665             


Leu Pro  Met Glu Asn Gly Leu  Asn Ser Ile Glu Trp  Arg Leu Arg 
    1670                 1675                 1680             


Lys Glu  Gln Ile Lys Gly Lys  Val Thr Ile Phe Gly  Arg Lys Leu 
    1685                 1690                 1695             


Arg Val  His Gly Arg Asn Leu  Leu Ser Ile Asp Tyr  Asp Arg Asn 
    1700                 1705                 1710             


Ile Arg  Thr Glu Lys Ile Tyr  Asp Asp His Arg Lys  Phe Thr Leu 
    1715                 1720                 1725             


Arg Ile  Ile Tyr Asp Gln Val  Gly Arg Pro Phe Leu  Trp Leu Pro 
    1730                 1735                 1740             


Ser Ser  Gly Leu Ala Ala Val  Asn Val Ser Tyr Phe  Phe Asn Gly 
    1745                 1750                 1755             


Arg Leu  Ala Gly Leu Gln Arg  Gly Ala Met Ser Glu  Arg Thr Asp 
    1760                 1765                 1770             


Ile Asp  Lys Gln Gly Arg Ile  Val Ser Arg Met Phe  Ala Asp Gly 
    1775                 1780                 1785             


Lys Val  Trp Ser Tyr Ser Tyr  Leu Asp Lys Ser Met  Val Leu Leu 
    1790                 1795                 1800             


Leu Gln  Ser Gln Arg Gln Tyr  Ile Phe Glu Tyr Asp  Ser Ser Asp 
    1805                 1810                 1815             


Arg Leu  Leu Ala Val Thr Met  Pro Ser Val Ala Arg  His Ser Met 
    1820                 1825                 1830             


Ser Thr  His Thr Ser Ile Gly  Tyr Ile Arg Asn Ile  Tyr Asn Pro 
    1835                 1840                 1845             


Pro Glu  Ser Asn Ala Ser Val  Ile Phe Asp Tyr Ser  Asp Asp Gly 
    1850                 1855                 1860             


Arg Ile  Leu Lys Thr Ser Phe  Leu Gly Thr Gly Arg  Gln Val Phe 
    1865                 1870                 1875             


Tyr Lys  Tyr Gly Lys Leu Ser  Lys Leu Ser Glu Ile  Val Tyr Asp 
    1880                 1885                 1890             


Ser Thr  Ala Val Thr Phe Gly  Tyr Asp Glu Thr Thr  Gly Val Leu 
    1895                 1900                 1905             


Lys Met  Val Asn Leu Gln Ser  Gly Gly Phe Ser Cys  Thr Ile Arg 
    1910                 1915                 1920             


Tyr Arg  Lys Ile Gly Pro Leu  Val Asp Lys Gln Ile  Tyr Arg Phe 
    1925                 1930                 1935             


Ser Glu  Glu Gly Met Val Asn  Ala Arg Phe Asp Tyr  Thr Tyr His 
    1940                 1945                 1950             


Asp Asn  Ser Phe Arg Ile Ala  Ser Ile Lys Pro Val  Ile Ser Glu 
    1955                 1960                 1965             


Thr Pro  Leu Pro Val Asp Leu  Tyr Arg Tyr Asp Glu  Ile Ser Gly 
    1970                 1975                 1980             


Lys Val  Glu His Phe Gly Lys  Phe Gly Val Ile Tyr  Tyr Asp Ile 
    1985                 1990                 1995             


Asn Gln  Ile Ile Thr Thr Ala  Val Met Thr Leu Ser  Lys His Phe 
    2000                 2005                 2010             


Asp Thr  His Gly Arg Ile Lys  Glu Val Gln Tyr Glu  Met Phe Arg 
    2015                 2020                 2025             


Ser Leu  Met Tyr Trp Met Thr  Val Gln Tyr Asp Ser  Met Gly Arg 
    2030                 2035                 2040             


Val Ile  Lys Arg Glu Leu Lys  Leu Gly Pro Tyr Ala  Asn Thr Thr 
    2045                 2050                 2055             


Lys Tyr  Thr Tyr Asp Tyr Asp  Gly Asp Gly Gln Leu  Gln Ser Val 
    2060                 2065                 2070             


Ala Val  Asn Asp Arg Pro Thr  Trp Arg Tyr Ser Tyr  Asp Leu Asn 
    2075                 2080                 2085             


Gly Asn  Leu His Leu Leu Asn  Pro Gly Asn Ser Val  Arg Leu Met 
    2090                 2095                 2100             


Pro Leu  Arg Tyr Asp Leu Arg  Asp Arg Ile Thr Arg  Leu Gly Asp 
    2105                 2110                 2115             


Val Gln  Tyr Lys Ile Asp Asp  Asp Gly Tyr Leu Cys  Gln Arg Gly 
    2120                 2125                 2130             


Ser Asp  Ile Phe Glu Tyr Asn  Ser Lys Gly Leu Leu  Thr Arg Ala 
    2135                 2140                 2145             


Tyr Asn  Lys Ala Ser Gly Trp  Ser Val Gln Tyr Arg  Tyr Asp Gly 
    2150                 2155                 2160             


Val Gly  Arg Arg Ala Ser Tyr  Lys Thr Asn Leu Gly  His His Leu 
    2165                 2170                 2175             


Gln Tyr  Phe Tyr Ser Asp Leu  His Asn Pro Thr Arg  Ile Thr His 
    2180                 2185                 2190             


Val Tyr  Asn His Ser Asn Ser  Glu Ile Thr Ser Leu  Tyr Tyr Asp 
    2195                 2200                 2205             


Leu Gln  Gly His Leu Phe Ala  Met Glu Ser Ser Ser  Gly Glu Glu 
    2210                 2215                 2220             


Tyr Tyr  Val Ala Ser Asp Asn  Thr Gly Thr Pro Leu  Ala Val Phe 
    2225                 2230                 2235             


Ser Ile  Asn Gly Leu Met Ile  Lys Gln Leu Gln Tyr  Thr Ala Tyr 
    2240                 2245                 2250             


Gly Glu  Ile Tyr Tyr Asp Ser  Asn Pro Asp Phe Gln  Met Val Ile 
    2255                 2260                 2265             


Gly Phe  His Gly Gly Leu Tyr  Asp Pro Leu Thr Lys  Leu Val His 
    2270                 2275                 2280             


Phe Thr  Gln Arg Asp Tyr Asp  Val Leu Ala Gly Arg  Trp Thr Ser 
    2285                 2290                 2295             


Pro Asp  Tyr Thr Met Trp Lys  Asn Val Gly Lys Glu  Pro Ala Pro 
    2300                 2305                 2310             


Phe Asn  Leu Tyr Met Phe Lys  Ser Asn Asn Pro Leu  Ser Ser Glu 
    2315                 2320                 2325             


Leu Asp  Leu Lys Asn Tyr Val  Thr Asp Val Lys Ser  Trp Leu Val 
    2330                 2335                 2340             


Met Phe  Gly Phe Gln Leu Ser  Asn Ile Ile Pro Gly  Phe Pro Arg 
    2345                 2350                 2355             


Ala Lys  Met Tyr Phe Val Pro  Pro Pro Tyr Glu Leu  Ser Glu Ser 
    2360                 2365                 2370             


Gln Ala  Ser Glu Asn Gly Gln  Leu Ile Thr Gly Val  Gln Gln Thr 
    2375                 2380                 2385             


Thr Glu  Arg His Asn Gln Ala  Phe Met Ala Leu Glu  Gly Gln Val 
    2390                 2395                 2400             


Ile Thr  Lys Lys Leu His Ala  Ser Ile Arg Glu Lys  Ala Gly His 
    2405                 2410                 2415             


Trp Phe  Ala Thr Thr Thr Pro  Ile Ile Gly Lys Gly  Ile Met Phe 
    2420                 2425                 2430             


Ala Ile  Lys Glu Gly Arg Val  Thr Thr Gly Val Ser  Ser Ile Ala 
    2435                 2440                 2445             


Ser Glu  Asp Ser Arg Lys Val  Ala Ser Val Leu Asn  Asn Ala Tyr 
    2450                 2455                 2460             


Tyr Leu  Asp Lys Met His Tyr  Ser Ile Glu Gly Lys  Asp Thr His 
    2465                 2470                 2475             


Tyr Phe  Val Lys Ile Gly Ser  Ala Asp Gly Asp Leu  Val Thr Leu 
    2480                 2485                 2490             


Gly Thr  Thr Ile Gly Arg Lys  Val Leu Glu Ser Gly  Val Asn Val 
    2495                 2500                 2505             


Thr Val  Ser Gln Pro Thr Leu  Leu Val Asn Gly Arg  Thr Arg Arg 
    2510                 2515                 2520             


Phe Thr  Asn Ile Glu Phe Gln  Tyr Ser Thr Leu Leu  Leu Ser Ile 
    2525                 2530                 2535             


Arg Tyr  Gly Leu Thr Pro Asp  Thr Leu Asp Glu Glu  Lys Ala Arg 
    2540                 2545                 2550             


Val Leu  Asp Gln Ala Arg Gln  Arg Ala Leu Gly Thr  Ala Trp Ala 
    2555                 2560                 2565             


Lys Glu  Gln Gln Lys Ala Arg  Asp Gly Arg Glu Gly  Ser Arg Leu 
    2570                 2575                 2580             


Trp Thr  Glu Gly Glu Lys Gln  Gln Leu Leu Ser Thr  Gly Arg Val 
    2585                 2590                 2595             


Gln Gly  Tyr Glu Gly Tyr Tyr  Val Leu Pro Val Glu  Gln Tyr Pro 
    2600                 2605                 2610             


Glu Leu  Ala Asp Ser Ser Ser  Asn Ile Gln Phe Leu  Arg Gln Asn 
    2615                 2620                 2625             


Glu Met  Gly Lys Arg 
    2630             


<210>  83
<211>  4248
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (189)..(2720)
<223>  

<400>  83
aagacctcca tcagctcgcc gcgcagcgcg gctgtatttg cggcctgtgc gagtaggcgc     60

ttgggcactc agtctccctg gcgagcgacg ggcagaaatc tcgaaccagt ggagcgcact    120

cgtaacctgg atcccagaag gtcgcgaagg cagtaccgtt tcctcagcgg cggactgctg    180

cagtaaga atg tct ttt cca cct cat ttg aat cgc cct ccc atg gga atc     230
         Met Ser Phe Pro Pro His Leu Asn Arg Pro Pro Met Gly Ile        
         1               5                   10                         

cca gca ctc cca cca ggg atc cca ccc ccg cag ttt cca gga ttt cct      278
Pro Ala Leu Pro Pro Gly Ile Pro Pro Pro Gln Phe Pro Gly Phe Pro         
15                  20                  25                  30          

cca cct gta cct cca ggg acc cca atg att cct gta cca atg agc att      326
Pro Pro Val Pro Pro Gly Thr Pro Met Ile Pro Val Pro Met Ser Ile         
                35                  40                  45              

atg gct cct gct cca act gtc tta gta ccc act gtg tct atg gtt gga      374
Met Ala Pro Ala Pro Thr Val Leu Val Pro Thr Val Ser Met Val Gly         
            50                  55                  60                  

aag cat ttg ggc gca aga aag gat cat cca ggc tta aag gct aaa gaa      422
Lys His Leu Gly Ala Arg Lys Asp His Pro Gly Leu Lys Ala Lys Glu         
        65                  70                  75                      

aat gat gaa aat tgt ggt cct act acc act gtt ttt gtt ggc aac att      470
Asn Asp Glu Asn Cys Gly Pro Thr Thr Thr Val Phe Val Gly Asn Ile         
    80                  85                  90                          

tcc gag aaa gct tca gac atg ctt ata aga caa ctc tta gct aaa tgt      518
Ser Glu Lys Ala Ser Asp Met Leu Ile Arg Gln Leu Leu Ala Lys Cys         
95                  100                 105                 110         

ggt ttg gtt ttg agc tgg aag aga gta caa ggt gct tcc gga aag ctt      566
Gly Leu Val Leu Ser Trp Lys Arg Val Gln Gly Ala Ser Gly Lys Leu         
                115                 120                 125             

caa gcc ttc gga ttc tgt gag tac aag gag cca gaa tct acc ctc cgt      614
Gln Ala Phe Gly Phe Cys Glu Tyr Lys Glu Pro Glu Ser Thr Leu Arg         
            130                 135                 140                 

gca ctc aga tta tta cat gac ctg caa att gga gag aaa aag cta ctc      662
Ala Leu Arg Leu Leu His Asp Leu Gln Ile Gly Glu Lys Lys Leu Leu         
        145                 150                 155                     

gtt aaa gtt gat gca aag aca aag gca cag ctg gat gaa tgg aaa gca      710
Val Lys Val Asp Ala Lys Thr Lys Ala Gln Leu Asp Glu Trp Lys Ala         
    160                 165                 170                         

aag aag aaa gct tct aat ggg aat gca agg cca gaa act gtc act aat      758
Lys Lys Lys Ala Ser Asn Gly Asn Ala Arg Pro Glu Thr Val Thr Asn         
175                 180                 185                 190         

gac gat gaa gaa gcc ttg gat gaa gaa aca aag agg aga gat cag atg      806
Asp Asp Glu Glu Ala Leu Asp Glu Glu Thr Lys Arg Arg Asp Gln Met         
                195                 200                 205             

att aaa ggg gct att gaa gtt tta att cgt gaa tac tcc agt gag cta      854
Ile Lys Gly Ala Ile Glu Val Leu Ile Arg Glu Tyr Ser Ser Glu Leu         
            210                 215                 220                 

aat gcc ccc tca cag gaa tct gat tct cac ccc agg aag aag aag aag      902
Asn Ala Pro Ser Gln Glu Ser Asp Ser His Pro Arg Lys Lys Lys Lys         
        225                 230                 235                     

gaa aag aag gag gac att ttc cgc aga ttt cca gtg gcc cca ctg atc      950
Glu Lys Lys Glu Asp Ile Phe Arg Arg Phe Pro Val Ala Pro Leu Ile         
    240                 245                 250                         

cct tat cca ctc atc act aag gag gat ata aat gct ata gaa atg gaa      998
Pro Tyr Pro Leu Ile Thr Lys Glu Asp Ile Asn Ala Ile Glu Met Glu         
255                 260                 265                 270         

gaa gac aaa aga gac ctg ata tct cga gag atc agc aaa ttc aga gac     1046
Glu Asp Lys Arg Asp Leu Ile Ser Arg Glu Ile Ser Lys Phe Arg Asp         
                275                 280                 285             

aca cat aag aaa ctg gaa gaa gag aaa ggc aaa aag gaa aaa gaa aga     1094
Thr His Lys Lys Leu Glu Glu Glu Lys Gly Lys Lys Glu Lys Glu Arg         
            290                 295                 300                 

cag gaa att gag aaa gaa cgg aga gaa aga gag agg gag cgt gaa agg     1142
Gln Glu Ile Glu Lys Glu Arg Arg Glu Arg Glu Arg Glu Arg Glu Arg         
        305                 310                 315                     

gaa cga gaa agg cga gaa cgg gaa cga gaa agg gaa aga gaa cgt gaa     1190
Glu Arg Glu Arg Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu         
    320                 325                 330                         

cga gaa aag gag aaa gaa cgg gag cgg gaa cga gaa cgg gat agg gac     1238
Arg Glu Lys Glu Lys Glu Arg Glu Arg Glu Arg Glu Arg Asp Arg Asp         
335                 340                 345                 350         

cgt gac cgg aca aaa gag aga gac cga gat cgg gat cga gag aga gat     1286
Arg Asp Arg Thr Lys Glu Arg Asp Arg Asp Arg Asp Arg Glu Arg Asp         
                355                 360                 365             

cgt gac cgg gat aga gaa agg agc tca gat cgt aat aag gat cgc agt     1334
Arg Asp Arg Asp Arg Glu Arg Ser Ser Asp Arg Asn Lys Asp Arg Ser         
            370                 375                 380                 

cga tca aga gaa aaa agc aga gat cgt gaa agg gaa cga gag cgg gaa     1382
Arg Ser Arg Glu Lys Ser Arg Asp Arg Glu Arg Glu Arg Glu Arg Glu         
        385                 390                 395                     

aga gag aga gag aga gaa cga gag cga gaa cga gaa cgg gag cga gag     1430
Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu         
    400                 405                 410                         

aga gag cga gag agg gaa cgg gag cga gaa aga gaa aaa gac aaa aaa     1478
Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Lys Asp Lys Lys         
415                 420                 425                 430         

cgg gac cga gaa gaa gat gaa gaa gat gca tac gaa cga aga aaa ctt     1526
Arg Asp Arg Glu Glu Asp Glu Glu Asp Ala Tyr Glu Arg Arg Lys Leu         
                435                 440                 445             

gaa aga aaa ctc cga gag aaa gaa gct gct tat caa gag cgc ctt aag     1574
Glu Arg Lys Leu Arg Glu Lys Glu Ala Ala Tyr Gln Glu Arg Leu Lys         
            450                 455                 460                 

aat tgg gaa atc aga gaa cga aag aaa acc cgg gaa tat gag aaa gaa     1622
Asn Trp Glu Ile Arg Glu Arg Lys Lys Thr Arg Glu Tyr Glu Lys Glu         
        465                 470                 475                     

gct gaa aga gaa gaa gaa aga aga aga gaa atg gcc aaa gaa gct aaa     1670
Ala Glu Arg Glu Glu Glu Arg Arg Arg Glu Met Ala Lys Glu Ala Lys         
    480                 485                 490                         

cga cta aaa gaa ttc tta gaa gac tat gat gat gat aga gat gac ccc     1718
Arg Leu Lys Glu Phe Leu Glu Asp Tyr Asp Asp Asp Arg Asp Asp Pro         
495                 500                 505                 510         

aaa tat tac aga gga agt gct ctt cag aaa agg ttg cgt gat aga gaa     1766
Lys Tyr Tyr Arg Gly Ser Ala Leu Gln Lys Arg Leu Arg Asp Arg Glu         
                515                 520                 525             

aag gaa atg gaa gca gat gaa cga gat agg aag aga gag aag gag gag     1814
Lys Glu Met Glu Ala Asp Glu Arg Asp Arg Lys Arg Glu Lys Glu Glu         
            530                 535                 540                 

ctt gag gaa atc agg cag cgc ctt ctg gca gaa ggg cat cca gat cca     1862
Leu Glu Glu Ile Arg Gln Arg Leu Leu Ala Glu Gly His Pro Asp Pro         
        545                 550                 555                     

gat gca gag ctc cag agg atg gaa caa gag gct gag agg cgc agg cag     1910
Asp Ala Glu Leu Gln Arg Met Glu Gln Glu Ala Glu Arg Arg Arg Gln         
    560                 565                 570                         

cca caa ata aag caa gag cca gaa tca gaa gag gag gaa gaa gaa aag     1958
Pro Gln Ile Lys Gln Glu Pro Glu Ser Glu Glu Glu Glu Glu Glu Lys         
575                 580                 585                 590         

caa gaa aaa gaa gaa aaa cga gaa gaa ccc atg gaa gag gaa gag gag     2006
Gln Glu Lys Glu Glu Lys Arg Glu Glu Pro Met Glu Glu Glu Glu Glu         
                595                 600                 605             

cca gag caa aag cct tgt ctg aaa cct act ctg agg ccc atc agc tct     2054
Pro Glu Gln Lys Pro Cys Leu Lys Pro Thr Leu Arg Pro Ile Ser Ser         
            610                 615                 620                 

gct cca tct gtt tcc tct gcc agt ggc aat gca aca cct aac act cct     2102
Ala Pro Ser Val Ser Ser Ala Ser Gly Asn Ala Thr Pro Asn Thr Pro         
        625                 630                 635                     

ggg gat gag tct ccc tgt ggt att att att cct cat gaa aac tca cca     2150
Gly Asp Glu Ser Pro Cys Gly Ile Ile Ile Pro His Glu Asn Ser Pro         
    640                 645                 650                         

gat caa cag caa cct gag gag cat agg cca aaa ata gga cta agt ctt     2198
Asp Gln Gln Gln Pro Glu Glu His Arg Pro Lys Ile Gly Leu Ser Leu         
655                 660                 665                 670         

aaa ctg ggt gct tcc aat agt cct ggt cag cct aat tct gtg aag aga     2246
Lys Leu Gly Ala Ser Asn Ser Pro Gly Gln Pro Asn Ser Val Lys Arg         
                675                 680                 685             

aag aaa cta cct gta gat agt gtc ttt aac aaa ttt gag gat gaa gac     2294
Lys Lys Leu Pro Val Asp Ser Val Phe Asn Lys Phe Glu Asp Glu Asp         
            690                 695                 700                 

agt gat gac gta ccc cga aaa agg aaa ctg gtt ccc ttg gat tat ggt     2342
Ser Asp Asp Val Pro Arg Lys Arg Lys Leu Val Pro Leu Asp Tyr Gly         
        705                 710                 715                     

gaa gat gat aaa aat gca acc aaa ggc act gta aac act gaa gaa aag     2390
Glu Asp Asp Lys Asn Ala Thr Lys Gly Thr Val Asn Thr Glu Glu Lys         
    720                 725                 730                         

cgt aaa cac att aag agt ctc att gag aaa atc cct aca gcc aaa cct     2438
Arg Lys His Ile Lys Ser Leu Ile Glu Lys Ile Pro Thr Ala Lys Pro         
735                 740                 745                 750         

gag ctc ttc gct tat ccc ctg gat tgg tct att gtg gat tct ata ctg     2486
Glu Leu Phe Ala Tyr Pro Leu Asp Trp Ser Ile Val Asp Ser Ile Leu         
                755                 760                 765             

atg gaa cgt cga att aga cca tgg att aat aag aaa atc ata gaa tat     2534
Met Glu Arg Arg Ile Arg Pro Trp Ile Asn Lys Lys Ile Ile Glu Tyr         
            770                 775                 780                 

ata ggt gaa gaa gaa gct aca tta gtt gat ttt gtt tgt tct aag gtt     2582
Ile Gly Glu Glu Glu Ala Thr Leu Val Asp Phe Val Cys Ser Lys Val         
        785                 790                 795                     

atg gct cat agt tca ccc cag agc att tta gat gat gtt gcc atg gta     2630
Met Ala His Ser Ser Pro Gln Ser Ile Leu Asp Asp Val Ala Met Val         
    800                 805                 810                         

ctt gat gaa gaa gca gaa gtt ttt ata gtc aaa atg tgg aga tta ttg     2678
Leu Asp Glu Glu Ala Glu Val Phe Ile Val Lys Met Trp Arg Leu Leu         
815                 820                 825                 830         

ata tat gaa aca gaa gcc aag aaa att ggt ctt gtg aag taa             2720
Ile Tyr Glu Thr Glu Ala Lys Lys Ile Gly Leu Val Lys                     
                835                 840                                 

aactttttat atttagagtt ccatttcaga tttcttcttt gccacccttt taaggacttt   2780

gaatttttct ttgtctttga agacattgtg agatctgtaa tttttttttt ttgtagaaaa   2840

tgtgaatttt ttggtcctct aatttgttgt tgccctgtgt actcccttgg ttgtaaagtc   2900

atctgaatcc ttggttctct ttatactcac caggtacaaa ttactggtat gttttataag   2960

ccgcagctac tgtacacagc ctatctgata taatcttgtt ctgctgattt gtttcttgta   3020

aatattaaaa cgactcccca attattttgc agaattgcac ttaatattga aatgtactgt   3080

ataggaacca acatgaacaa ttttaattga aaacaccagt cataaactat taccaccccc   3140

actctctttt gatcagaaat ggcaagccct tgtgaaggca tggagtttaa aattggaatg   3200

caaaaattag cagacaatcc attcctactg tatttctgta tgaatgtgtt tgtgaatgta   3260

tgtgtaaaag tctttctttt ccctaatttg ctttggtggg gtccttaaaa catttcccaa   3320

ctaaagaata gaattgtaaa ggaaaagtgg tactgttcca acctgaaatg tctgttataa   3380

ttaggttatt agtttcccag agcatggtgt tctcgtgtcg tgagcaatgt ggtttgctaa   3440

ctggatgggg ttttcttatt aataagatgg ctgcttcagc ttctctttta aaggaatgtg   3500

gatcatagtg atttttcctt ttaattttat tgctcagaaa tgaggcatat cctaaaaatc   3560

ctggagagct gtatttaatg catttttgca ctaattggtc cttagtttaa ttctattgta   3620

tctgtttatt taacaaaaaa ttcatcatac caaaaagtgt aagtgaaaac cccctttaaa   3680

acaaaacaaa aaaatgaaat aaaattaggc aaattgacag acagtgagag ttttacaaac   3740

atgataggta ttctgctcgg caatttgtaa gtttacatgt tatttaagga taaaggtaaa   3800

tcattcaagg cagttaccaa ccactaacta tttgttttca tttttgtctt gtagaaggtt   3860

tatatcttgt tttaccttgg ctcattagtg tttaaaaatg tactgatgat gtgcttagag   3920

aaattcctgg ggctttcttc gttgtagatc agaatttcac cagggagtaa aattacctga   3980

aaacgtaaga agttttaaac agcttttcac acaaattaga tgcaactgtt cccatgtctg   4040

agtacttatt taaaagaaag gtaaagattg gcctgttaga aaaagcataa tgtgagcttt   4100

ggattactgg attttttttt tttttaaaca cacctggaga ggacatttga aaacactgtt   4160

cttaccctcg aaccctgatg tggttccatt atgtaaatat ttcaaatatt aaaaatgtat   4220

atatttgaaa aaaaaaaaaa aaaaaaaa                                      4248


<210>  84
<211>  843
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Ser Phe Pro Pro His Leu Asn Arg Pro Pro Met Gly Ile Pro Ala 
1               5                   10                  15      


Leu Pro Pro Gly Ile Pro Pro Pro Gln Phe Pro Gly Phe Pro Pro Pro 
            20                  25                  30          


Val Pro Pro Gly Thr Pro Met Ile Pro Val Pro Met Ser Ile Met Ala 
        35                  40                  45              


Pro Ala Pro Thr Val Leu Val Pro Thr Val Ser Met Val Gly Lys His 
    50                  55                  60                  


Leu Gly Ala Arg Lys Asp His Pro Gly Leu Lys Ala Lys Glu Asn Asp 
65                  70                  75                  80  


Glu Asn Cys Gly Pro Thr Thr Thr Val Phe Val Gly Asn Ile Ser Glu 
                85                  90                  95      


Lys Ala Ser Asp Met Leu Ile Arg Gln Leu Leu Ala Lys Cys Gly Leu 
            100                 105                 110         


Val Leu Ser Trp Lys Arg Val Gln Gly Ala Ser Gly Lys Leu Gln Ala 
        115                 120                 125             


Phe Gly Phe Cys Glu Tyr Lys Glu Pro Glu Ser Thr Leu Arg Ala Leu 
    130                 135                 140                 


Arg Leu Leu His Asp Leu Gln Ile Gly Glu Lys Lys Leu Leu Val Lys 
145                 150                 155                 160 


Val Asp Ala Lys Thr Lys Ala Gln Leu Asp Glu Trp Lys Ala Lys Lys 
                165                 170                 175     


Lys Ala Ser Asn Gly Asn Ala Arg Pro Glu Thr Val Thr Asn Asp Asp 
            180                 185                 190         


Glu Glu Ala Leu Asp Glu Glu Thr Lys Arg Arg Asp Gln Met Ile Lys 
        195                 200                 205             


Gly Ala Ile Glu Val Leu Ile Arg Glu Tyr Ser Ser Glu Leu Asn Ala 
    210                 215                 220                 


Pro Ser Gln Glu Ser Asp Ser His Pro Arg Lys Lys Lys Lys Glu Lys 
225                 230                 235                 240 


Lys Glu Asp Ile Phe Arg Arg Phe Pro Val Ala Pro Leu Ile Pro Tyr 
                245                 250                 255     


Pro Leu Ile Thr Lys Glu Asp Ile Asn Ala Ile Glu Met Glu Glu Asp 
            260                 265                 270         


Lys Arg Asp Leu Ile Ser Arg Glu Ile Ser Lys Phe Arg Asp Thr His 
        275                 280                 285             


Lys Lys Leu Glu Glu Glu Lys Gly Lys Lys Glu Lys Glu Arg Gln Glu 
    290                 295                 300                 


Ile Glu Lys Glu Arg Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg 
305                 310                 315                 320 


Glu Arg Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu 
                325                 330                 335     


Lys Glu Lys Glu Arg Glu Arg Glu Arg Glu Arg Asp Arg Asp Arg Asp 
            340                 345                 350         


Arg Thr Lys Glu Arg Asp Arg Asp Arg Asp Arg Glu Arg Asp Arg Asp 
        355                 360                 365             


Arg Asp Arg Glu Arg Ser Ser Asp Arg Asn Lys Asp Arg Ser Arg Ser 
    370                 375                 380                 


Arg Glu Lys Ser Arg Asp Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu 
385                 390                 395                 400 


Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu 
                405                 410                 415     


Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Lys Asp Lys Lys Arg Asp 
            420                 425                 430         


Arg Glu Glu Asp Glu Glu Asp Ala Tyr Glu Arg Arg Lys Leu Glu Arg 
        435                 440                 445             


Lys Leu Arg Glu Lys Glu Ala Ala Tyr Gln Glu Arg Leu Lys Asn Trp 
    450                 455                 460                 


Glu Ile Arg Glu Arg Lys Lys Thr Arg Glu Tyr Glu Lys Glu Ala Glu 
465                 470                 475                 480 


Arg Glu Glu Glu Arg Arg Arg Glu Met Ala Lys Glu Ala Lys Arg Leu 
                485                 490                 495     


Lys Glu Phe Leu Glu Asp Tyr Asp Asp Asp Arg Asp Asp Pro Lys Tyr 
            500                 505                 510         


Tyr Arg Gly Ser Ala Leu Gln Lys Arg Leu Arg Asp Arg Glu Lys Glu 
        515                 520                 525             


Met Glu Ala Asp Glu Arg Asp Arg Lys Arg Glu Lys Glu Glu Leu Glu 
    530                 535                 540                 


Glu Ile Arg Gln Arg Leu Leu Ala Glu Gly His Pro Asp Pro Asp Ala 
545                 550                 555                 560 


Glu Leu Gln Arg Met Glu Gln Glu Ala Glu Arg Arg Arg Gln Pro Gln 
                565                 570                 575     


Ile Lys Gln Glu Pro Glu Ser Glu Glu Glu Glu Glu Glu Lys Gln Glu 
            580                 585                 590         


Lys Glu Glu Lys Arg Glu Glu Pro Met Glu Glu Glu Glu Glu Pro Glu 
        595                 600                 605             


Gln Lys Pro Cys Leu Lys Pro Thr Leu Arg Pro Ile Ser Ser Ala Pro 
    610                 615                 620                 


Ser Val Ser Ser Ala Ser Gly Asn Ala Thr Pro Asn Thr Pro Gly Asp 
625                 630                 635                 640 


Glu Ser Pro Cys Gly Ile Ile Ile Pro His Glu Asn Ser Pro Asp Gln 
                645                 650                 655     


Gln Gln Pro Glu Glu His Arg Pro Lys Ile Gly Leu Ser Leu Lys Leu 
            660                 665                 670         


Gly Ala Ser Asn Ser Pro Gly Gln Pro Asn Ser Val Lys Arg Lys Lys 
        675                 680                 685             


Leu Pro Val Asp Ser Val Phe Asn Lys Phe Glu Asp Glu Asp Ser Asp 
    690                 695                 700                 


Asp Val Pro Arg Lys Arg Lys Leu Val Pro Leu Asp Tyr Gly Glu Asp 
705                 710                 715                 720 


Asp Lys Asn Ala Thr Lys Gly Thr Val Asn Thr Glu Glu Lys Arg Lys 
                725                 730                 735     


His Ile Lys Ser Leu Ile Glu Lys Ile Pro Thr Ala Lys Pro Glu Leu 
            740                 745                 750         


Phe Ala Tyr Pro Leu Asp Trp Ser Ile Val Asp Ser Ile Leu Met Glu 
        755                 760                 765             


Arg Arg Ile Arg Pro Trp Ile Asn Lys Lys Ile Ile Glu Tyr Ile Gly 
    770                 775                 780                 


Glu Glu Glu Ala Thr Leu Val Asp Phe Val Cys Ser Lys Val Met Ala 
785                 790                 795                 800 


His Ser Ser Pro Gln Ser Ile Leu Asp Asp Val Ala Met Val Leu Asp 
                805                 810                 815     


Glu Glu Ala Glu Val Phe Ile Val Lys Met Trp Arg Leu Leu Ile Tyr 
            820                 825                 830         


Glu Thr Glu Ala Lys Lys Ile Gly Leu Val Lys 
        835                 840             


<210>  85
<211>  4056
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (189)..(2528)
<223>  

<400>  85
aagacctcca tcagctcgcc gcgcagcgcg gctgtatttg cggcctgtgc gagtaggcgc     60

ttgggcactc agtctccctg gcgagcgacg ggcagaaatc tcgaaccagt ggagcgcact    120

cgtaacctgg atcccagaag gtcgcgaagg cagtaccgtt tcctcagcgg cggactgctg    180

cagtaaga atg tct ttt cca cct cat ttg aat cgc cct ccc atg gga atc     230
         Met Ser Phe Pro Pro His Leu Asn Arg Pro Pro Met Gly Ile        
         1               5                   10                         

cca gca ctc cca cca ggg atc cca ccc ccg cag ttt cca gga ttt cct      278
Pro Ala Leu Pro Pro Gly Ile Pro Pro Pro Gln Phe Pro Gly Phe Pro         
15                  20                  25                  30          

cca cct gta cct cca ggg acc cca atg att cct gta cca atg agc att      326
Pro Pro Val Pro Pro Gly Thr Pro Met Ile Pro Val Pro Met Ser Ile         
                35                  40                  45              

atg gct cct gct cca act gtc tta gta ccc act gtg tct atg gtt gga      374
Met Ala Pro Ala Pro Thr Val Leu Val Pro Thr Val Ser Met Val Gly         
            50                  55                  60                  

aag cat ttg ggc gca aga aag gat cat cca ggc tta aag gct aaa gaa      422
Lys His Leu Gly Ala Arg Lys Asp His Pro Gly Leu Lys Ala Lys Glu         
        65                  70                  75                      

aat gat gaa aat tgt ggt cct act acc act gtt ttt gtt ggc aac att      470
Asn Asp Glu Asn Cys Gly Pro Thr Thr Thr Val Phe Val Gly Asn Ile         
    80                  85                  90                          

tcc gag aaa gct tca gac atg ctt ata aga caa ctc tta gct aaa tgt      518
Ser Glu Lys Ala Ser Asp Met Leu Ile Arg Gln Leu Leu Ala Lys Cys         
95                  100                 105                 110         

ggt ttg gtt ttg agc tgg aag aga gta caa ggt gct tcc gga aag ctt      566
Gly Leu Val Leu Ser Trp Lys Arg Val Gln Gly Ala Ser Gly Lys Leu         
                115                 120                 125             

caa gcc ttc gga ttc tgt gag tac aag gag cca gaa tct acc ctc cgt      614
Gln Ala Phe Gly Phe Cys Glu Tyr Lys Glu Pro Glu Ser Thr Leu Arg         
            130                 135                 140                 

gca ctc aga tta tta cat gac ctg caa att gga gag aaa aag cta ctc      662
Ala Leu Arg Leu Leu His Asp Leu Gln Ile Gly Glu Lys Lys Leu Leu         
        145                 150                 155                     

gtt aaa gtt gat gca aag aca aag gca cag ctg gat gaa tgg aaa gca      710
Val Lys Val Asp Ala Lys Thr Lys Ala Gln Leu Asp Glu Trp Lys Ala         
    160                 165                 170                         

aag aag aaa gct tct aat ggg aat gca agg cca gaa act gtc act aat      758
Lys Lys Lys Ala Ser Asn Gly Asn Ala Arg Pro Glu Thr Val Thr Asn         
175                 180                 185                 190         

gac gat gaa gaa gcc ttg gat gaa gaa aca aag agg aga gat cag atg      806
Asp Asp Glu Glu Ala Leu Asp Glu Glu Thr Lys Arg Arg Asp Gln Met         
                195                 200                 205             

att aaa ggg gct att gaa gtt tta att cgt gaa tac tcc agt gag cta      854
Ile Lys Gly Ala Ile Glu Val Leu Ile Arg Glu Tyr Ser Ser Glu Leu         
            210                 215                 220                 

aat gcc ccc tca cag gaa tct gat tct cac ccc agg aag aag aag aag      902
Asn Ala Pro Ser Gln Glu Ser Asp Ser His Pro Arg Lys Lys Lys Lys         
        225                 230                 235                     

gaa aag aag gag gac att ttc cgc aga ttt cca gtg gcc cca ctg atc      950
Glu Lys Lys Glu Asp Ile Phe Arg Arg Phe Pro Val Ala Pro Leu Ile         
    240                 245                 250                         

cct tat cca ctc atc act aag gag gat ata aat gct ata gaa atg gaa      998
Pro Tyr Pro Leu Ile Thr Lys Glu Asp Ile Asn Ala Ile Glu Met Glu         
255                 260                 265                 270         

gaa gac aaa aga gac ctg ata tct cga gag atc agc aaa ttc aga gac     1046
Glu Asp Lys Arg Asp Leu Ile Ser Arg Glu Ile Ser Lys Phe Arg Asp         
                275                 280                 285             

aca cat aag aaa ctg gaa gaa gag aaa ggc aaa aag gaa aaa gaa aga     1094
Thr His Lys Lys Leu Glu Glu Glu Lys Gly Lys Lys Glu Lys Glu Arg         
            290                 295                 300                 

cag gaa att gag aaa gaa cgg aga gaa aga gag agg gag cgt gaa agg     1142
Gln Glu Ile Glu Lys Glu Arg Arg Glu Arg Glu Arg Glu Arg Glu Arg         
        305                 310                 315                     

gaa cga gaa agg cga gaa cgg gaa cga gaa agg gaa cga gag cgg gaa     1190
Glu Arg Glu Arg Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu         
    320                 325                 330                         

aga gag aga gag aga gaa cga gag cga gaa cga gaa cgg gag cga gag     1238
Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu         
335                 340                 345                 350         

aga gag cga gag agg gaa cgg gag cga gaa aga gaa aaa gac aaa aaa     1286
Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Lys Asp Lys Lys         
                355                 360                 365             

cgg gac cga gaa gaa gat gaa gaa gat gca tac gaa cga aga aaa ctt     1334
Arg Asp Arg Glu Glu Asp Glu Glu Asp Ala Tyr Glu Arg Arg Lys Leu         
            370                 375                 380                 

gaa aga aaa ctc cga gag aaa gaa gct gct tat caa gag cgc ctt aag     1382
Glu Arg Lys Leu Arg Glu Lys Glu Ala Ala Tyr Gln Glu Arg Leu Lys         
        385                 390                 395                     

aat tgg gaa atc aga gaa cga aag aaa acc cgg gaa tat gag aaa gaa     1430
Asn Trp Glu Ile Arg Glu Arg Lys Lys Thr Arg Glu Tyr Glu Lys Glu         
    400                 405                 410                         

gct gaa aga gaa gaa gaa aga aga aga gaa atg gcc aaa gaa gct aaa     1478
Ala Glu Arg Glu Glu Glu Arg Arg Arg Glu Met Ala Lys Glu Ala Lys         
415                 420                 425                 430         

cga cta aaa gaa ttc tta gaa gac tat gat gat gat aga gat gac ccc     1526
Arg Leu Lys Glu Phe Leu Glu Asp Tyr Asp Asp Asp Arg Asp Asp Pro         
                435                 440                 445             

aaa tat tac aga gga agt gct ctt cag aaa agg ttg cgt gat aga gaa     1574
Lys Tyr Tyr Arg Gly Ser Ala Leu Gln Lys Arg Leu Arg Asp Arg Glu         
            450                 455                 460                 

aag gaa atg gaa gca gat gaa cga gat agg aag aga gag aag gag gag     1622
Lys Glu Met Glu Ala Asp Glu Arg Asp Arg Lys Arg Glu Lys Glu Glu         
        465                 470                 475                     

ctt gag gaa atc agg cag cgc ctt ctg gca gaa ggg cat cca gat cca     1670
Leu Glu Glu Ile Arg Gln Arg Leu Leu Ala Glu Gly His Pro Asp Pro         
    480                 485                 490                         

gat gca gag ctc cag agg atg gaa caa gag gct gag agg cgc agg cag     1718
Asp Ala Glu Leu Gln Arg Met Glu Gln Glu Ala Glu Arg Arg Arg Gln         
495                 500                 505                 510         

cca caa ata aag caa gag cca gaa tca gaa gag gag gaa gaa gaa aag     1766
Pro Gln Ile Lys Gln Glu Pro Glu Ser Glu Glu Glu Glu Glu Glu Lys         
                515                 520                 525             

caa gaa aaa gaa gaa aaa cga gaa gaa ccc atg gaa gag gaa gag gag     1814
Gln Glu Lys Glu Glu Lys Arg Glu Glu Pro Met Glu Glu Glu Glu Glu         
            530                 535                 540                 

cca gag caa aag cct tgt ctg aaa cct act ctg agg ccc atc agc tct     1862
Pro Glu Gln Lys Pro Cys Leu Lys Pro Thr Leu Arg Pro Ile Ser Ser         
        545                 550                 555                     

gct cca tct gtt tcc tct gcc agt ggc aat gca aca cct aac act cct     1910
Ala Pro Ser Val Ser Ser Ala Ser Gly Asn Ala Thr Pro Asn Thr Pro         
    560                 565                 570                         

ggg gat gag tct ccc tgt ggt att att att cct cat gaa aac tca cca     1958
Gly Asp Glu Ser Pro Cys Gly Ile Ile Ile Pro His Glu Asn Ser Pro         
575                 580                 585                 590         

gat caa cag caa cct gag gag cat agg cca aaa ata gga cta agt ctt     2006
Asp Gln Gln Gln Pro Glu Glu His Arg Pro Lys Ile Gly Leu Ser Leu         
                595                 600                 605             

aaa ctg ggt gct tcc aat agt cct ggt cag cct aat tct gtg aag aga     2054
Lys Leu Gly Ala Ser Asn Ser Pro Gly Gln Pro Asn Ser Val Lys Arg         
            610                 615                 620                 

aag aaa cta cct gta gat agt gtc ttt aac aaa ttt gag gat gaa gac     2102
Lys Lys Leu Pro Val Asp Ser Val Phe Asn Lys Phe Glu Asp Glu Asp         
        625                 630                 635                     

agt gat gac gta ccc cga aaa agg aaa ctg gtt ccc ttg gat tat ggt     2150
Ser Asp Asp Val Pro Arg Lys Arg Lys Leu Val Pro Leu Asp Tyr Gly         
    640                 645                 650                         

gaa gat gat aaa aat gca acc aaa ggc act gta aac act gaa gaa aag     2198
Glu Asp Asp Lys Asn Ala Thr Lys Gly Thr Val Asn Thr Glu Glu Lys         
655                 660                 665                 670         

cgt aaa cac att aag agt ctc att gag aaa atc cct aca gcc aaa cct     2246
Arg Lys His Ile Lys Ser Leu Ile Glu Lys Ile Pro Thr Ala Lys Pro         
                675                 680                 685             

gag ctc ttc gct tat ccc ctg gat tgg tct att gtg gat tct ata ctg     2294
Glu Leu Phe Ala Tyr Pro Leu Asp Trp Ser Ile Val Asp Ser Ile Leu         
            690                 695                 700                 

atg gaa cgt cga att aga cca tgg att aat aag aaa atc ata gaa tat     2342
Met Glu Arg Arg Ile Arg Pro Trp Ile Asn Lys Lys Ile Ile Glu Tyr         
        705                 710                 715                     

ata ggt gaa gaa gaa gct aca tta gtt gat ttt gtt tgt tct aag gtt     2390
Ile Gly Glu Glu Glu Ala Thr Leu Val Asp Phe Val Cys Ser Lys Val         
    720                 725                 730                         

atg gct cat agt tca ccc cag agc att tta gat gat gtt gcc atg gta     2438
Met Ala His Ser Ser Pro Gln Ser Ile Leu Asp Asp Val Ala Met Val         
735                 740                 745                 750         

ctt gat gaa gaa gca gaa gtt ttt ata gtc aaa atg tgg aga tta ttg     2486
Leu Asp Glu Glu Ala Glu Val Phe Ile Val Lys Met Trp Arg Leu Leu         
                755                 760                 765             

ata tat gaa aca gaa gcc aag aaa att ggt ctt gtg aag taa             2528
Ile Tyr Glu Thr Glu Ala Lys Lys Ile Gly Leu Val Lys                     
            770                 775                                     

aactttttat atttagagtt ccatttcaga tttcttcttt gccacccttt taaggacttt   2588

gaatttttct ttgtctttga agacattgtg agatctgtaa tttttttttt ttgtagaaaa   2648

tgtgaatttt ttggtcctct aatttgttgt tgccctgtgt actcccttgg ttgtaaagtc   2708

atctgaatcc ttggttctct ttatactcac caggtacaaa ttactggtat gttttataag   2768

ccgcagctac tgtacacagc ctatctgata taatcttgtt ctgctgattt gtttcttgta   2828

aatattaaaa cgactcccca attattttgc agaattgcac ttaatattga aatgtactgt   2888

ataggaacca acatgaacaa ttttaattga aaacaccagt cataaactat taccaccccc   2948

actctctttt gatcagaaat ggcaagccct tgtgaaggca tggagtttaa aattggaatg   3008

caaaaattag cagacaatcc attcctactg tatttctgta tgaatgtgtt tgtgaatgta   3068

tgtgtaaaag tctttctttt ccctaatttg ctttggtggg gtccttaaaa catttcccaa   3128

ctaaagaata gaattgtaaa ggaaaagtgg tactgttcca acctgaaatg tctgttataa   3188

ttaggttatt agtttcccag agcatggtgt tctcgtgtcg tgagcaatgt ggtttgctaa   3248

ctggatgggg ttttcttatt aataagatgg ctgcttcagc ttctctttta aaggaatgtg   3308

gatcatagtg atttttcctt ttaattttat tgctcagaaa tgaggcatat cctaaaaatc   3368

ctggagagct gtatttaatg catttttgca ctaattggtc cttagtttaa ttctattgta   3428

tctgtttatt taacaaaaaa ttcatcatac caaaaagtgt aagtgaaaac cccctttaaa   3488

acaaaacaaa aaaatgaaat aaaattaggc aaattgacag acagtgagag ttttacaaac   3548

atgataggta ttctgctcgg caatttgtaa gtttacatgt tatttaagga taaaggtaaa   3608

tcattcaagg cagttaccaa ccactaacta tttgttttca tttttgtctt gtagaaggtt   3668

tatatcttgt tttaccttgg ctcattagtg tttaaaaatg tactgatgat gtgcttagag   3728

aaattcctgg ggctttcttc gttgtagatc agaatttcac cagggagtaa aattacctga   3788

aaacgtaaga agttttaaac agcttttcac acaaattaga tgcaactgtt cccatgtctg   3848

agtacttatt taaaagaaag gtaaagattg gcctgttaga aaaagcataa tgtgagcttt   3908

ggattactgg attttttttt tttttaaaca cacctggaga ggacatttga aaacactgtt   3968

cttaccctcg aaccctgatg tggttccatt atgtaaatat ttcaaatatt aaaaatgtat   4028

atatttgaaa aaaaaaaaaa aaaaaaaa                                      4056


<210>  86
<211>  779
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Ser Phe Pro Pro His Leu Asn Arg Pro Pro Met Gly Ile Pro Ala 
1               5                   10                  15      


Leu Pro Pro Gly Ile Pro Pro Pro Gln Phe Pro Gly Phe Pro Pro Pro 
            20                  25                  30          


Val Pro Pro Gly Thr Pro Met Ile Pro Val Pro Met Ser Ile Met Ala 
        35                  40                  45              


Pro Ala Pro Thr Val Leu Val Pro Thr Val Ser Met Val Gly Lys His 
    50                  55                  60                  


Leu Gly Ala Arg Lys Asp His Pro Gly Leu Lys Ala Lys Glu Asn Asp 
65                  70                  75                  80  


Glu Asn Cys Gly Pro Thr Thr Thr Val Phe Val Gly Asn Ile Ser Glu 
                85                  90                  95      


Lys Ala Ser Asp Met Leu Ile Arg Gln Leu Leu Ala Lys Cys Gly Leu 
            100                 105                 110         


Val Leu Ser Trp Lys Arg Val Gln Gly Ala Ser Gly Lys Leu Gln Ala 
        115                 120                 125             


Phe Gly Phe Cys Glu Tyr Lys Glu Pro Glu Ser Thr Leu Arg Ala Leu 
    130                 135                 140                 


Arg Leu Leu His Asp Leu Gln Ile Gly Glu Lys Lys Leu Leu Val Lys 
145                 150                 155                 160 


Val Asp Ala Lys Thr Lys Ala Gln Leu Asp Glu Trp Lys Ala Lys Lys 
                165                 170                 175     


Lys Ala Ser Asn Gly Asn Ala Arg Pro Glu Thr Val Thr Asn Asp Asp 
            180                 185                 190         


Glu Glu Ala Leu Asp Glu Glu Thr Lys Arg Arg Asp Gln Met Ile Lys 
        195                 200                 205             


Gly Ala Ile Glu Val Leu Ile Arg Glu Tyr Ser Ser Glu Leu Asn Ala 
    210                 215                 220                 


Pro Ser Gln Glu Ser Asp Ser His Pro Arg Lys Lys Lys Lys Glu Lys 
225                 230                 235                 240 


Lys Glu Asp Ile Phe Arg Arg Phe Pro Val Ala Pro Leu Ile Pro Tyr 
                245                 250                 255     


Pro Leu Ile Thr Lys Glu Asp Ile Asn Ala Ile Glu Met Glu Glu Asp 
            260                 265                 270         


Lys Arg Asp Leu Ile Ser Arg Glu Ile Ser Lys Phe Arg Asp Thr His 
        275                 280                 285             


Lys Lys Leu Glu Glu Glu Lys Gly Lys Lys Glu Lys Glu Arg Gln Glu 
    290                 295                 300                 


Ile Glu Lys Glu Arg Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg 
305                 310                 315                 320 


Glu Arg Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu 
                325                 330                 335     


Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu 
            340                 345                 350         


Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Lys Asp Lys Lys Arg Asp 
        355                 360                 365             


Arg Glu Glu Asp Glu Glu Asp Ala Tyr Glu Arg Arg Lys Leu Glu Arg 
    370                 375                 380                 


Lys Leu Arg Glu Lys Glu Ala Ala Tyr Gln Glu Arg Leu Lys Asn Trp 
385                 390                 395                 400 


Glu Ile Arg Glu Arg Lys Lys Thr Arg Glu Tyr Glu Lys Glu Ala Glu 
                405                 410                 415     


Arg Glu Glu Glu Arg Arg Arg Glu Met Ala Lys Glu Ala Lys Arg Leu 
            420                 425                 430         


Lys Glu Phe Leu Glu Asp Tyr Asp Asp Asp Arg Asp Asp Pro Lys Tyr 
        435                 440                 445             


Tyr Arg Gly Ser Ala Leu Gln Lys Arg Leu Arg Asp Arg Glu Lys Glu 
    450                 455                 460                 


Met Glu Ala Asp Glu Arg Asp Arg Lys Arg Glu Lys Glu Glu Leu Glu 
465                 470                 475                 480 


Glu Ile Arg Gln Arg Leu Leu Ala Glu Gly His Pro Asp Pro Asp Ala 
                485                 490                 495     


Glu Leu Gln Arg Met Glu Gln Glu Ala Glu Arg Arg Arg Gln Pro Gln 
            500                 505                 510         


Ile Lys Gln Glu Pro Glu Ser Glu Glu Glu Glu Glu Glu Lys Gln Glu 
        515                 520                 525             


Lys Glu Glu Lys Arg Glu Glu Pro Met Glu Glu Glu Glu Glu Pro Glu 
    530                 535                 540                 


Gln Lys Pro Cys Leu Lys Pro Thr Leu Arg Pro Ile Ser Ser Ala Pro 
545                 550                 555                 560 


Ser Val Ser Ser Ala Ser Gly Asn Ala Thr Pro Asn Thr Pro Gly Asp 
                565                 570                 575     


Glu Ser Pro Cys Gly Ile Ile Ile Pro His Glu Asn Ser Pro Asp Gln 
            580                 585                 590         


Gln Gln Pro Glu Glu His Arg Pro Lys Ile Gly Leu Ser Leu Lys Leu 
        595                 600                 605             


Gly Ala Ser Asn Ser Pro Gly Gln Pro Asn Ser Val Lys Arg Lys Lys 
    610                 615                 620                 


Leu Pro Val Asp Ser Val Phe Asn Lys Phe Glu Asp Glu Asp Ser Asp 
625                 630                 635                 640 


Asp Val Pro Arg Lys Arg Lys Leu Val Pro Leu Asp Tyr Gly Glu Asp 
                645                 650                 655     


Asp Lys Asn Ala Thr Lys Gly Thr Val Asn Thr Glu Glu Lys Arg Lys 
            660                 665                 670         


His Ile Lys Ser Leu Ile Glu Lys Ile Pro Thr Ala Lys Pro Glu Leu 
        675                 680                 685             


Phe Ala Tyr Pro Leu Asp Trp Ser Ile Val Asp Ser Ile Leu Met Glu 
    690                 695                 700                 


Arg Arg Ile Arg Pro Trp Ile Asn Lys Lys Ile Ile Glu Tyr Ile Gly 
705                 710                 715                 720 


Glu Glu Glu Ala Thr Leu Val Asp Phe Val Cys Ser Lys Val Met Ala 
                725                 730                 735     


His Ser Ser Pro Gln Ser Ile Leu Asp Asp Val Ala Met Val Leu Asp 
            740                 745                 750         


Glu Glu Ala Glu Val Phe Ile Val Lys Met Trp Arg Leu Leu Ile Tyr 
        755                 760                 765             


Glu Thr Glu Ala Lys Lys Ile Gly Leu Val Lys 
    770                 775                 


<210>  87
<211>  5866
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (1)..(5721)
<223>  

<400>  87
atg att aag agg gac tgt ggg tat cct ggt ctc cgc gtg tgt gag tac       48
Met Ile Lys Arg Asp Cys Gly Tyr Pro Gly Leu Arg Val Cys Glu Tyr         
1               5                   10                  15              

cgc ggc gcg agg tta gtg gta gct ggg tgc aga cgc cgt ggc gct gga       96
Arg Gly Ala Arg Leu Val Val Ala Gly Cys Arg Arg Arg Gly Ala Gly         
            20                  25                  30                  

gac cca aac atg gca aac ctg gaa gaa agc ttc ccc cga gga ggt aca      144
Asp Pro Asn Met Ala Asn Leu Glu Glu Ser Phe Pro Arg Gly Gly Thr         
        35                  40                  45                      

aga aag atc cac aaa cca gag aaa gct ttc cag cag tca gtt gaa caa      192
Arg Lys Ile His Lys Pro Glu Lys Ala Phe Gln Gln Ser Val Glu Gln         
    50                  55                  60                          

gac aac tta ttt gat att tct act gaa gag gga tcc acc aaa aga aaa      240
Asp Asn Leu Phe Asp Ile Ser Thr Glu Glu Gly Ser Thr Lys Arg Lys         
65                  70                  75                  80          

aag agc cag aag ggg cca gca aaa aca aaa aag ttg aaa atc gaa aag      288
Lys Ser Gln Lys Gly Pro Ala Lys Thr Lys Lys Leu Lys Ile Glu Lys         
                85                  90                  95              

aga gaa agc agc aag tcc gca aga gag aag ttt gaa atc ctt agt gtt      336
Arg Glu Ser Ser Lys Ser Ala Arg Glu Lys Phe Glu Ile Leu Ser Val         
            100                 105                 110                 

gag tcc ctg tgt gag gga atg cgt att ttg ggt tgc gtg aaa gag gtg      384
Glu Ser Leu Cys Glu Gly Met Arg Ile Leu Gly Cys Val Lys Glu Val         
        115                 120                 125                     

aat gaa ctg gaa ctg gtg att agt ctc ccc aat ggc ctc cag ggc ttt      432
Asn Glu Leu Glu Leu Val Ile Ser Leu Pro Asn Gly Leu Gln Gly Phe         
    130                 135                 140                         

gtg caa gtc act gaa atc tgt gat gcc tac acc aaa aag ctg aat gag      480
Val Gln Val Thr Glu Ile Cys Asp Ala Tyr Thr Lys Lys Leu Asn Glu         
145                 150                 155                 160         

cag gtg aca caa gaa caa cct ctg aag gac cta ctt cac ttg cct gaa      528
Gln Val Thr Gln Glu Gln Pro Leu Lys Asp Leu Leu His Leu Pro Glu         
                165                 170                 175             

ctt ttc tca cct gga atg ctg gta aga tgt gtg gtg agc agt ctg ggc      576
Leu Phe Ser Pro Gly Met Leu Val Arg Cys Val Val Ser Ser Leu Gly         
            180                 185                 190                 

atc aca gac agg ggc aag aag agt gtc aag ctg tct ctg aac ccc aaa      624
Ile Thr Asp Arg Gly Lys Lys Ser Val Lys Leu Ser Leu Asn Pro Lys         
        195                 200                 205                     

aat gtc aac aga gtg ctg agt gct gag gcc ctg aag cct ggc atg cta      672
Asn Val Asn Arg Val Leu Ser Ala Glu Ala Leu Lys Pro Gly Met Leu         
    210                 215                 220                         

ctt aca ggt acc gta tcc agc ctg gaa gac cat ggc tac cta gtg gac      720
Leu Thr Gly Thr Val Ser Ser Leu Glu Asp His Gly Tyr Leu Val Asp         
225                 230                 235                 240         

att ggt gtt gat ggg acc aga gct ttt ctg cca ctg ctg aaa gcc cag      768
Ile Gly Val Asp Gly Thr Arg Ala Phe Leu Pro Leu Leu Lys Ala Gln         
                245                 250                 255             

gag tac atc aga cag aag aac aaa ggt gct aaa cta aag gtg ggt cag      816
Glu Tyr Ile Arg Gln Lys Asn Lys Gly Ala Lys Leu Lys Val Gly Gln         
            260                 265                 270                 

tac ctg aac tgc att gtt gaa aag gtg aaa ggc aac gga gga gtt gtt      864
Tyr Leu Asn Cys Ile Val Glu Lys Val Lys Gly Asn Gly Gly Val Val         
        275                 280                 285                     

agt ctg tct gtt ggt cac tca gag gtt tct acg gcc att gct act gaa      912
Ser Leu Ser Val Gly His Ser Glu Val Ser Thr Ala Ile Ala Thr Glu         
    290                 295                 300                         

cag cag agc tgg aac ctt aat aac ttg cta cca gga ctg gtg gtc aaa      960
Gln Gln Ser Trp Asn Leu Asn Asn Leu Leu Pro Gly Leu Val Val Lys         
305                 310                 315                 320         

gct cag gta cag aag gtg act cca ttt ggc ctt acg cta aac ttc ctc     1008
Ala Gln Val Gln Lys Val Thr Pro Phe Gly Leu Thr Leu Asn Phe Leu         
                325                 330                 335             

aca ttc ttc acg ggc gtg gtt gac ttt atg cac ctg gat ccc aag aaa     1056
Thr Phe Phe Thr Gly Val Val Asp Phe Met His Leu Asp Pro Lys Lys         
            340                 345                 350                 

gct gga aca tat ttc tca aat cag gca gtg agg gcc tgc atc ctt tgc     1104
Ala Gly Thr Tyr Phe Ser Asn Gln Ala Val Arg Ala Cys Ile Leu Cys         
        355                 360                 365                     

gtc cat cct cga acc aga gtt gtg cac ctg agc ctg cgc ccc atc ttc     1152
Val His Pro Arg Thr Arg Val Val His Leu Ser Leu Arg Pro Ile Phe         
    370                 375                 380                         

cta cag cct gga cgc cca ctc acc cga ctc tct tgc cag aac ctt gga     1200
Leu Gln Pro Gly Arg Pro Leu Thr Arg Leu Ser Cys Gln Asn Leu Gly         
385                 390                 395                 400         

gca gtg ctg gat gat gtt cct gtc cag ggt ttt ttc aaa aag gct ggg     1248
Ala Val Leu Asp Asp Val Pro Val Gln Gly Phe Phe Lys Lys Ala Gly         
                405                 410                 415             

gcc acc ttt agg ctg aag gat ggg gtt ctg gcc tat gcc cgg ctc agc     1296
Ala Thr Phe Arg Leu Lys Asp Gly Val Leu Ala Tyr Ala Arg Leu Ser         
            420                 425                 430                 

cat ctc tct gat tct aag aac gtc ttc aat cct gag gcc ttc aag cca     1344
His Leu Ser Asp Ser Lys Asn Val Phe Asn Pro Glu Ala Phe Lys Pro         
        435                 440                 445                     

ggg aac act cac aag tgt aga att att gac tac agc caa atg gat gaa     1392
Gly Asn Thr His Lys Cys Arg Ile Ile Asp Tyr Ser Gln Met Asp Glu         
    450                 455                 460                         

ctg gcc ttg ctc tct cta cga acg tct att att gaa gct cag tac ctt     1440
Leu Ala Leu Leu Ser Leu Arg Thr Ser Ile Ile Glu Ala Gln Tyr Leu         
465                 470                 475                 480         

aga tat cat gac atc gaa cct ggg gca gtg gta aag ggc aca gtg cta     1488
Arg Tyr His Asp Ile Glu Pro Gly Ala Val Val Lys Gly Thr Val Leu         
                485                 490                 495             

acc ata aag tca tat ggg atg ctg gtg aag gtg ggc gag cag atg agg     1536
Thr Ile Lys Ser Tyr Gly Met Leu Val Lys Val Gly Glu Gln Met Arg         
            500                 505                 510                 

ggc ctg gta cct ccc atg cac ctg gct gac atc ctg atg aag aat ccg     1584
Gly Leu Val Pro Pro Met His Leu Ala Asp Ile Leu Met Lys Asn Pro         
        515                 520                 525                     

gag aag aag tac cac atc ggg gat gag gtc aag tgc cgg gtt ttg ctt     1632
Glu Lys Lys Tyr His Ile Gly Asp Glu Val Lys Cys Arg Val Leu Leu         
    530                 535                 540                         

tgt gac cct gaa gcc aag aag ctg atg atg acc ctg aaa aaa acc ctg     1680
Cys Asp Pro Glu Ala Lys Lys Leu Met Met Thr Leu Lys Lys Thr Leu         
545                 550                 555                 560         

att gag tcc aaa cta cct gtc att acc tgc tat gcc gat gcc aag cct     1728
Ile Glu Ser Lys Leu Pro Val Ile Thr Cys Tyr Ala Asp Ala Lys Pro         
                565                 570                 575             

ggt ctg cag aca cat ggc ttc atc atc agg gtc aag gac tat ggc tgc     1776
Gly Leu Gln Thr His Gly Phe Ile Ile Arg Val Lys Asp Tyr Gly Cys         
            580                 585                 590                 

att gtg aag ttc tac aac aat gtg cag gga ctg gtg ccc aag cat gag     1824
Ile Val Lys Phe Tyr Asn Asn Val Gln Gly Leu Val Pro Lys His Glu         
        595                 600                 605                     

ctc agt act gag tat atc cct gac ccg gag aga gtt ttt tac act ggc     1872
Leu Ser Thr Glu Tyr Ile Pro Asp Pro Glu Arg Val Phe Tyr Thr Gly         
    610                 615                 620                         

cag gtg gtg aag gtt gtc gta ttg aac tgt gag cca tcc aaa gag agg     1920
Gln Val Val Lys Val Val Val Leu Asn Cys Glu Pro Ser Lys Glu Arg         
625                 630                 635                 640         

atg ctc tta tcc ttc aag ctg tcg agt gat cca gag cca aag aaa gag     1968
Met Leu Leu Ser Phe Lys Leu Ser Ser Asp Pro Glu Pro Lys Lys Glu         
                645                 650                 655             

cct gca gga cac agt cag aag aaa gga aaa gcc att aac att ggg cag     2016
Pro Ala Gly His Ser Gln Lys Lys Gly Lys Ala Ile Asn Ile Gly Gln         
            660                 665                 670                 

ttg gta gat gtg aag gtt tta gag aag acc aaa gat ggg ctg gag gtg     2064
Leu Val Asp Val Lys Val Leu Glu Lys Thr Lys Asp Gly Leu Glu Val         
        675                 680                 685                     

gct gtc ctg ccc cac aac atc cgt gct ttc ctc ccc aca tct cat ctg     2112
Ala Val Leu Pro His Asn Ile Arg Ala Phe Leu Pro Thr Ser His Leu         
    690                 695                 700                         

tcg gac cac gtt gcc aac ggc cca ttg tta cat cat tgg ctc cag gca     2160
Ser Asp His Val Ala Asn Gly Pro Leu Leu His His Trp Leu Gln Ala         
705                 710                 715                 720         

ggt gac atc ctt cac cga gtc ctg tgt ctg agc cag agc gag ggg cgt     2208
Gly Asp Ile Leu His Arg Val Leu Cys Leu Ser Gln Ser Glu Gly Arg         
                725                 730                 735             

gtt ctt ctt tgc agg aag cca gcc ttg gtc tcc aca gta gaa ggt ggc     2256
Val Leu Leu Cys Arg Lys Pro Ala Leu Val Ser Thr Val Glu Gly Gly         
            740                 745                 750                 

cag gat ccc aag aac ttc tca gaa atc cat cct gga atg ctg ctc att     2304
Gln Asp Pro Lys Asn Phe Ser Glu Ile His Pro Gly Met Leu Leu Ile         
        755                 760                 765                     

ggt ttt gtg aag agc atc aag gac tat ggc gtg ttc atc cag ttc ccc     2352
Gly Phe Val Lys Ser Ile Lys Asp Tyr Gly Val Phe Ile Gln Phe Pro         
    770                 775                 780                         

tca ggt ctt agc gga ctg gcc cca aaa gct atc atg agt gac aaa ttt     2400
Ser Gly Leu Ser Gly Leu Ala Pro Lys Ala Ile Met Ser Asp Lys Phe         
785                 790                 795                 800         

gtg acc tcc aca agt gac cac ttt gtt gag ggc cag aca gta gcg gca     2448
Val Thr Ser Thr Ser Asp His Phe Val Glu Gly Gln Thr Val Ala Ala         
                805                 810                 815             

aag gtg acc aat gtg gat gag gag aag cag cgg atg ctg ctg tca ctg     2496
Lys Val Thr Asn Val Asp Glu Glu Lys Gln Arg Met Leu Leu Ser Leu         
            820                 825                 830                 

cgg ctg tcg gac tgt ggt ctg ggg gac ttg gct atc acc agc ctc ctc     2544
Arg Leu Ser Asp Cys Gly Leu Gly Asp Leu Ala Ile Thr Ser Leu Leu         
        835                 840                 845                     

ctc ctg aat cag tgc ctg gag gag ctg cag ggc gtg cgc agc ctt atg     2592
Leu Leu Asn Gln Cys Leu Glu Glu Leu Gln Gly Val Arg Ser Leu Met         
    850                 855                 860                         

agc aac cga gac tct gtg ttg atc cag acg ctg gcc gag atg acc cca     2640
Ser Asn Arg Asp Ser Val Leu Ile Gln Thr Leu Ala Glu Met Thr Pro         
865                 870                 875                 880         

gga atg ttc ctt gac cta gtg gtg cag gag gtg ttg gaa gat ggc tct     2688
Gly Met Phe Leu Asp Leu Val Val Gln Glu Val Leu Glu Asp Gly Ser         
                885                 890                 895             

gtg gta ttc agt ggg ggt cca gtg ccc gac ctg gtc ctg aaa gcc agc     2736
Val Val Phe Ser Gly Gly Pro Val Pro Asp Leu Val Leu Lys Ala Ser         
            900                 905                 910                 

aga tac cat cgc gca ggg cag gag gtg gaa tct ggg cag aaa aag aag     2784
Arg Tyr His Arg Ala Gly Gln Glu Val Glu Ser Gly Gln Lys Lys Lys         
        915                 920                 925                     

gtt gtt atc tta aat gtt gat ctt ttg aag ttg gaa gtg cac gtt tcc     2832
Val Val Ile Leu Asn Val Asp Leu Leu Lys Leu Glu Val His Val Ser         
    930                 935                 940                         

ctt cac cag gac ttg gtg aat aga aaa gct aga aag ctg agg aaa ggc     2880
Leu His Gln Asp Leu Val Asn Arg Lys Ala Arg Lys Leu Arg Lys Gly         
945                 950                 955                 960         

agc gaa cac cag gcg att gtg cag cac ttg gag aag tcc ttt gcc att     2928
Ser Glu His Gln Ala Ile Val Gln His Leu Glu Lys Ser Phe Ala Ile         
                965                 970                 975             

gcc tcc ttg gta gag acg ggc cac ctg gca gct ttc tcc ctg acc tct     2976
Ala Ser Leu Val Glu Thr Gly His Leu Ala Ala Phe Ser Leu Thr Ser         
            980                 985                 990                 

cac ctc aac gac acc ttc cgc ttt  gac tca gag aaa ttg  cag gtg gga   3024
His Leu Asn Asp Thr Phe Arg Phe  Asp Ser Glu Lys Leu  Gln Val Gly       
        995                 1000                 1005                   

cag ggt  gtc tcc cta acc ctc  aag acc aca gaa cca  gga gtg act      3069
Gln Gly  Val Ser Leu Thr Leu  Lys Thr Thr Glu Pro  Gly Val Thr          
    1010                 1015                 1020                      

ggc ctt  ctt ttg gct gtg gag  ggg ccg gct gcc aag  agg acc atg      3114
Gly Leu  Leu Leu Ala Val Glu  Gly Pro Ala Ala Lys  Arg Thr Met          
    1025                 1030                 1035                      

agg ccg  acc cag aag gac tct  gag aca gtt gat gag  gat gaa gaa      3159
Arg Pro  Thr Gln Lys Asp Ser  Glu Thr Val Asp Glu  Asp Glu Glu          
    1040                 1045                 1050                      

gtg gat  cca gct ctg act gta  ggg acc ata aag aag  cac acc ctc      3204
Val Asp  Pro Ala Leu Thr Val  Gly Thr Ile Lys Lys  His Thr Leu          
    1055                 1060                 1065                      

tcc atc  ggg gac atg gtc aca  ggg act gtc aag tcc  att aag cct      3249
Ser Ile  Gly Asp Met Val Thr  Gly Thr Val Lys Ser  Ile Lys Pro          
    1070                 1075                 1080                      

acc cat  gtg gtt gtg act ctg  gaa gat ggc att att  ggc tgt atc      3294
Thr His  Val Val Val Thr Leu  Glu Asp Gly Ile Ile  Gly Cys Ile          
    1085                 1090                 1095                      

cat gcc  tcc cac att cta gat  gat gtt cca gag ggc  acc tct cct      3339
His Ala  Ser His Ile Leu Asp  Asp Val Pro Glu Gly  Thr Ser Pro          
    1100                 1105                 1110                      

act acc  aag ctg aag gtt ggg  aag acg gtc act gcc  cga gtg att      3384
Thr Thr  Lys Leu Lys Val Gly  Lys Thr Val Thr Ala  Arg Val Ile          
    1115                 1120                 1125                      

ggc ggg  cga gac atg aag aca  ttc aag tat ctc cca  ata agt cac      3429
Gly Gly  Arg Asp Met Lys Thr  Phe Lys Tyr Leu Pro  Ile Ser His          
    1130                 1135                 1140                      

ccc aga  ttc gtt cga acc atc  ccg gag ctg agt gtt  cgg cca agt      3474
Pro Arg  Phe Val Arg Thr Ile  Pro Glu Leu Ser Val  Arg Pro Ser          
    1145                 1150                 1155                      

gag ctg  gag gat ggc cac act  gct ctt aac act cac  tct gtt agc      3519
Glu Leu  Glu Asp Gly His Thr  Ala Leu Asn Thr His  Ser Val Ser          
    1160                 1165                 1170                      

ccc atg  gag aag att aaa cag  tac cag gcc ggc cag  act gtt act      3564
Pro Met  Glu Lys Ile Lys Gln  Tyr Gln Ala Gly Gln  Thr Val Thr          
    1175                 1180                 1185                      

tgc ttc  tta aag aaa tac aat  gtg gtg aag aaa tgg  ctt gag gtg      3609
Cys Phe  Leu Lys Lys Tyr Asn  Val Val Lys Lys Trp  Leu Glu Val          
    1190                 1195                 1200                      

gag att  gcc cca gac atc cgg  ggg aga att ccc tta  ttg ctc act      3654
Glu Ile  Ala Pro Asp Ile Arg  Gly Arg Ile Pro Leu  Leu Leu Thr          
    1205                 1210                 1215                      

tct ctg  agc ttc aag gtt ctg  aag cat cca gat aag  aag ttc cgg      3699
Ser Leu  Ser Phe Lys Val Leu  Lys His Pro Asp Lys  Lys Phe Arg          
    1220                 1225                 1230                      

gtt ggc  cag gcc ctg agg gcc  acc gtt gtt ggc cca  gat tcc tcc      3744
Val Gly  Gln Ala Leu Arg Ala  Thr Val Val Gly Pro  Asp Ser Ser          
    1235                 1240                 1245                      

aag acc  ctc tta tgt ctg tcc  ctc aca ggt cct cac  aag ctt gag      3789
Lys Thr  Leu Leu Cys Leu Ser  Leu Thr Gly Pro His  Lys Leu Glu          
    1250                 1255                 1260                      

gaa ggg  gaa gtg gcc atg ggc  cga gtg gtg aag gtg  act ccc aac      3834
Glu Gly  Glu Val Ala Met Gly  Arg Val Val Lys Val  Thr Pro Asn          
    1265                 1270                 1275                      

gag ggg  ctg acc gtc tcc ttc  ccc ttt ggg aag ata  gga aca gtc      3879
Glu Gly  Leu Thr Val Ser Phe  Pro Phe Gly Lys Ile  Gly Thr Val          
    1280                 1285                 1290                      

agt ata  ttt cac atg agt gac  tcc tac tcc gag acg  ccc ctg gaa      3924
Ser Ile  Phe His Met Ser Asp  Ser Tyr Ser Glu Thr  Pro Leu Glu          
    1295                 1300                 1305                      

gac ttc  gtc ccc cag aag gtt  gtc aga tgt tac atc  ctg tcc act      3969
Asp Phe  Val Pro Gln Lys Val  Val Arg Cys Tyr Ile  Leu Ser Thr          
    1310                 1315                 1320                      

gca gac  aac gta ttg act ttg  tcg ctg cga tca tcc  aga aca aac      4014
Ala Asp  Asn Val Leu Thr Leu  Ser Leu Arg Ser Ser  Arg Thr Asn          
    1325                 1330                 1335                      

ccg gag  acg aaa agc aaa gta  gaa gat cca gag att  aac tcc atc      4059
Pro Glu  Thr Lys Ser Lys Val  Glu Asp Pro Glu Ile  Asn Ser Ile          
    1340                 1345                 1350                      

cag gac  att aag gaa ggg cag  ctt ctg agg ggc tat  gta ggg tcc      4104
Gln Asp  Ile Lys Glu Gly Gln  Leu Leu Arg Gly Tyr  Val Gly Ser          
    1355                 1360                 1365                      

atc cag  cca cac ggt gtg ttc  ttt cgc ctt ggc ccc  tcc gtt gtg      4149
Ile Gln  Pro His Gly Val Phe  Phe Arg Leu Gly Pro  Ser Val Val          
    1370                 1375                 1380                      

ggt ttg  gct cgg tac tcc cat  gtc tcc cag cac agc  ccg tcc aag      4194
Gly Leu  Ala Arg Tyr Ser His  Val Ser Gln His Ser  Pro Ser Lys          
    1385                 1390                 1395                      

aaa gcc  ctt tat aac aaa cac  ctc cct gaa ggg aag  ctg ctc aca      4239
Lys Ala  Leu Tyr Asn Lys His  Leu Pro Glu Gly Lys  Leu Leu Thr          
    1400                 1405                 1410                      

gcc agg  gtc cta cgc ctt aac  cac cag aag aac ctg  gta gag ctg      4284
Ala Arg  Val Leu Arg Leu Asn  His Gln Lys Asn Leu  Val Glu Leu          
    1415                 1420                 1425                      

tct ttc  ctc ccc gga gac act  ggg aag cca gac gtg  ctt tct gct      4329
Ser Phe  Leu Pro Gly Asp Thr  Gly Lys Pro Asp Val  Leu Ser Ala          
    1430                 1435                 1440                      

tcc ttg  gaa ggg caa ctt aca  aag caa gag gag agg  aaa aca gag      4374
Ser Leu  Glu Gly Gln Leu Thr  Lys Gln Glu Glu Arg  Lys Thr Glu          
    1445                 1450                 1455                      

gct gag  gag aga gac caa aaa  ggg gaa aag aaa aat  cag aaa agg      4419
Ala Glu  Glu Arg Asp Gln Lys  Gly Glu Lys Lys Asn  Gln Lys Arg          
    1460                 1465                 1470                      

aac gag  aag aag aac cag aag  ggg cag gag gag gtg  gag atg ccc      4464
Asn Glu  Lys Lys Asn Gln Lys  Gly Gln Glu Glu Val  Glu Met Pro          
    1475                 1480                 1485                      

agc aag  gag aag caa cag ccc  cag aag cca cag gcg  cag aag cgg      4509
Ser Lys  Glu Lys Gln Gln Pro  Gln Lys Pro Gln Ala  Gln Lys Arg          
    1490                 1495                 1500                      

ggc ggg  cgg gag tgc cgg gag  tct ggg agt gag cag  gaa aga gtg      4554
Gly Gly  Arg Glu Cys Arg Glu  Ser Gly Ser Glu Gln  Glu Arg Val          
    1505                 1510                 1515                      

agc aag  aag cca aag aaa gcc  ggc ctg tca gag gag  gac gac agc      4599
Ser Lys  Lys Pro Lys Lys Ala  Gly Leu Ser Glu Glu  Asp Asp Ser          
    1520                 1525                 1530                      

ctt gtg  gac gtg tac tat cgg  gag gga aaa gag gag  gca gaa gag      4644
Leu Val  Asp Val Tyr Tyr Arg  Glu Gly Lys Glu Glu  Ala Glu Glu          
    1535                 1540                 1545                      

acg aat  gtg ctg ccc aag gag  aag caa acc aag cca  gca gaa gcg      4689
Thr Asn  Val Leu Pro Lys Glu  Lys Gln Thr Lys Pro  Ala Glu Ala          
    1550                 1555                 1560                      

ccc cgg  ctg cag ctg tct tca  ggc ttc gct tgg aat  gtg gga cta      4734
Pro Arg  Leu Gln Leu Ser Ser  Gly Phe Ala Trp Asn  Val Gly Leu          
    1565                 1570                 1575                      

gac tct  ctg acc ccg gcc ttg  cca cct cta gca gag  agc tca gac      4779
Asp Ser  Leu Thr Pro Ala Leu  Pro Pro Leu Ala Glu  Ser Ser Asp          
    1580                 1585                 1590                      

agc gag  gag gat gag aag cca  cac caa gcc acg ata  aag aaa agc      4824
Ser Glu  Glu Asp Glu Lys Pro  His Gln Ala Thr Ile  Lys Lys Ser          
    1595                 1600                 1605                      

aag aaa  gaa agg gag ttg gag  aag cag aag gca gag  aag gaa ctg      4869
Lys Lys  Glu Arg Glu Leu Glu  Lys Gln Lys Ala Glu  Lys Glu Leu          
    1610                 1615                 1620                      

tcc cgc  att gag gag gcg ctg  atg gat cct ggg cgg  cag cca gag      4914
Ser Arg  Ile Glu Glu Ala Leu  Met Asp Pro Gly Arg  Gln Pro Glu          
    1625                 1630                 1635                      

tcc gcg  gat gat ttt gac cga  ctg gtg ctg agc tcc  ccc aac agc      4959
Ser Ala  Asp Asp Phe Asp Arg  Leu Val Leu Ser Ser  Pro Asn Ser          
    1640                 1645                 1650                      

tcc att  ctg tgg ctg cag tac  atg gct ttc cac ctg  cag gcc acg      5004
Ser Ile  Leu Trp Leu Gln Tyr  Met Ala Phe His Leu  Gln Ala Thr          
    1655                 1660                 1665                      

gag atc  gag aag gcc cgt gcc  gtg gct gag agg gcc  ctt aag acc      5049
Glu Ile  Glu Lys Ala Arg Ala  Val Ala Glu Arg Ala  Leu Lys Thr          
    1670                 1675                 1680                      

atc tcc  ttc aga gag gag cag  gag aag ctg aac gtg  tgg gtg gct      5094
Ile Ser  Phe Arg Glu Glu Gln  Glu Lys Leu Asn Val  Trp Val Ala          
    1685                 1690                 1695                      

ctg ctg  aac ctg gag aac atg  tac ggc tct cag gag  tcc ctg acc      5139
Leu Leu  Asn Leu Glu Asn Met  Tyr Gly Ser Gln Glu  Ser Leu Thr          
    1700                 1705                 1710                      

aag gtc  ttt gag cga gcc gtg  cag tac aac gag cct  ctc aaa gtc      5184
Lys Val  Phe Glu Arg Ala Val  Gln Tyr Asn Glu Pro  Leu Lys Val          
    1715                 1720                 1725                      

ttt ctc  cac ctg gct gac atc  tac gcc aag tca gag  aaa ttc cag      5229
Phe Leu  His Leu Ala Asp Ile  Tyr Ala Lys Ser Glu  Lys Phe Gln          
    1730                 1735                 1740                      

gaa gct  ggt gaa ctc tac aac  cgg atg ctg aag cgt  ttc cgg cag      5274
Glu Ala  Gly Glu Leu Tyr Asn  Arg Met Leu Lys Arg  Phe Arg Gln          
    1745                 1750                 1755                      

gag aaa  gct gtg tgg atc aaa  tac ggc gcc ttc ctt  ctg cgg agg      5319
Glu Lys  Ala Val Trp Ile Lys  Tyr Gly Ala Phe Leu  Leu Arg Arg          
    1760                 1765                 1770                      

agc cag  gct gca gcc agt cac  cgc gtg ctg cag cga  gcc ctg gag      5364
Ser Gln  Ala Ala Ala Ser His  Arg Val Leu Gln Arg  Ala Leu Glu          
    1775                 1780                 1785                      

tgc ctg  cct agc aag gag cat  gtg gat gtc att gcc  aag ttt gcc      5409
Cys Leu  Pro Ser Lys Glu His  Val Asp Val Ile Ala  Lys Phe Ala          
    1790                 1795                 1800                      

cag ctt  gag ttt cag ctg ggg  gat gca gag cgg gcc  aaa gcc att      5454
Gln Leu  Glu Phe Gln Leu Gly  Asp Ala Glu Arg Ala  Lys Ala Ile          
    1805                 1810                 1815                      

ttt gag  aac acg ctg agc acc  tac cca aag cgc aca  gat gtc tgg      5499
Phe Glu  Asn Thr Leu Ser Thr  Tyr Pro Lys Arg Thr  Asp Val Trp          
    1820                 1825                 1830                      

tcg gtc  tat atc gac atg acc  atc aag cac ggc agc  cag aag gac      5544
Ser Val  Tyr Ile Asp Met Thr  Ile Lys His Gly Ser  Gln Lys Asp          
    1835                 1840                 1845                      

gtc cgg  gac atc ttt gag cgg  gtc att cat ctg agc  ttg gcc ccc      5589
Val Arg  Asp Ile Phe Glu Arg  Val Ile His Leu Ser  Leu Ala Pro          
    1850                 1855                 1860                      

aag aga  atg aag ttc ttc ttc  aag cgc tac ctg gac  tac gag aag      5634
Lys Arg  Met Lys Phe Phe Phe  Lys Arg Tyr Leu Asp  Tyr Glu Lys          
    1865                 1870                 1875                      

cag cat  ggc act gag aag gat  gtg cag gca gtc aag  gcc aag gcc      5679
Gln His  Gly Thr Glu Lys Asp  Val Gln Ala Val Lys  Ala Lys Ala          
    1880                 1885                 1890                      

ctg gag  tat gtg gag gcc aag  agc tca gtg cta gag  gac tag          5721
Leu Glu  Tyr Val Glu Ala Lys  Ser Ser Val Leu Glu  Asp                  
    1895                 1900                 1905                      

tggcaggctg gctctgtggg acactgtcaa caatgggcca gcccggcccc gcctcgagtg   5781

cctgggcact cggaaaactg ttacctcagg actctattta aatgctgctt tttctgcagc   5841

acgcttgggg aaatcctgtc aggat                                         5866


<210>  88
<211>  1906
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ile Lys Arg Asp Cys Gly Tyr Pro Gly Leu Arg Val Cys Glu Tyr 
1               5                   10                  15      


Arg Gly Ala Arg Leu Val Val Ala Gly Cys Arg Arg Arg Gly Ala Gly 
            20                  25                  30          


Asp Pro Asn Met Ala Asn Leu Glu Glu Ser Phe Pro Arg Gly Gly Thr 
        35                  40                  45              


Arg Lys Ile His Lys Pro Glu Lys Ala Phe Gln Gln Ser Val Glu Gln 
    50                  55                  60                  


Asp Asn Leu Phe Asp Ile Ser Thr Glu Glu Gly Ser Thr Lys Arg Lys 
65                  70                  75                  80  


Lys Ser Gln Lys Gly Pro Ala Lys Thr Lys Lys Leu Lys Ile Glu Lys 
                85                  90                  95      


Arg Glu Ser Ser Lys Ser Ala Arg Glu Lys Phe Glu Ile Leu Ser Val 
            100                 105                 110         


Glu Ser Leu Cys Glu Gly Met Arg Ile Leu Gly Cys Val Lys Glu Val 
        115                 120                 125             


Asn Glu Leu Glu Leu Val Ile Ser Leu Pro Asn Gly Leu Gln Gly Phe 
    130                 135                 140                 


Val Gln Val Thr Glu Ile Cys Asp Ala Tyr Thr Lys Lys Leu Asn Glu 
145                 150                 155                 160 


Gln Val Thr Gln Glu Gln Pro Leu Lys Asp Leu Leu His Leu Pro Glu 
                165                 170                 175     


Leu Phe Ser Pro Gly Met Leu Val Arg Cys Val Val Ser Ser Leu Gly 
            180                 185                 190         


Ile Thr Asp Arg Gly Lys Lys Ser Val Lys Leu Ser Leu Asn Pro Lys 
        195                 200                 205             


Asn Val Asn Arg Val Leu Ser Ala Glu Ala Leu Lys Pro Gly Met Leu 
    210                 215                 220                 


Leu Thr Gly Thr Val Ser Ser Leu Glu Asp His Gly Tyr Leu Val Asp 
225                 230                 235                 240 


Ile Gly Val Asp Gly Thr Arg Ala Phe Leu Pro Leu Leu Lys Ala Gln 
                245                 250                 255     


Glu Tyr Ile Arg Gln Lys Asn Lys Gly Ala Lys Leu Lys Val Gly Gln 
            260                 265                 270         


Tyr Leu Asn Cys Ile Val Glu Lys Val Lys Gly Asn Gly Gly Val Val 
        275                 280                 285             


Ser Leu Ser Val Gly His Ser Glu Val Ser Thr Ala Ile Ala Thr Glu 
    290                 295                 300                 


Gln Gln Ser Trp Asn Leu Asn Asn Leu Leu Pro Gly Leu Val Val Lys 
305                 310                 315                 320 


Ala Gln Val Gln Lys Val Thr Pro Phe Gly Leu Thr Leu Asn Phe Leu 
                325                 330                 335     


Thr Phe Phe Thr Gly Val Val Asp Phe Met His Leu Asp Pro Lys Lys 
            340                 345                 350         


Ala Gly Thr Tyr Phe Ser Asn Gln Ala Val Arg Ala Cys Ile Leu Cys 
        355                 360                 365             


Val His Pro Arg Thr Arg Val Val His Leu Ser Leu Arg Pro Ile Phe 
    370                 375                 380                 


Leu Gln Pro Gly Arg Pro Leu Thr Arg Leu Ser Cys Gln Asn Leu Gly 
385                 390                 395                 400 


Ala Val Leu Asp Asp Val Pro Val Gln Gly Phe Phe Lys Lys Ala Gly 
                405                 410                 415     


Ala Thr Phe Arg Leu Lys Asp Gly Val Leu Ala Tyr Ala Arg Leu Ser 
            420                 425                 430         


His Leu Ser Asp Ser Lys Asn Val Phe Asn Pro Glu Ala Phe Lys Pro 
        435                 440                 445             


Gly Asn Thr His Lys Cys Arg Ile Ile Asp Tyr Ser Gln Met Asp Glu 
    450                 455                 460                 


Leu Ala Leu Leu Ser Leu Arg Thr Ser Ile Ile Glu Ala Gln Tyr Leu 
465                 470                 475                 480 


Arg Tyr His Asp Ile Glu Pro Gly Ala Val Val Lys Gly Thr Val Leu 
                485                 490                 495     


Thr Ile Lys Ser Tyr Gly Met Leu Val Lys Val Gly Glu Gln Met Arg 
            500                 505                 510         


Gly Leu Val Pro Pro Met His Leu Ala Asp Ile Leu Met Lys Asn Pro 
        515                 520                 525             


Glu Lys Lys Tyr His Ile Gly Asp Glu Val Lys Cys Arg Val Leu Leu 
    530                 535                 540                 


Cys Asp Pro Glu Ala Lys Lys Leu Met Met Thr Leu Lys Lys Thr Leu 
545                 550                 555                 560 


Ile Glu Ser Lys Leu Pro Val Ile Thr Cys Tyr Ala Asp Ala Lys Pro 
                565                 570                 575     


Gly Leu Gln Thr His Gly Phe Ile Ile Arg Val Lys Asp Tyr Gly Cys 
            580                 585                 590         


Ile Val Lys Phe Tyr Asn Asn Val Gln Gly Leu Val Pro Lys His Glu 
        595                 600                 605             


Leu Ser Thr Glu Tyr Ile Pro Asp Pro Glu Arg Val Phe Tyr Thr Gly 
    610                 615                 620                 


Gln Val Val Lys Val Val Val Leu Asn Cys Glu Pro Ser Lys Glu Arg 
625                 630                 635                 640 


Met Leu Leu Ser Phe Lys Leu Ser Ser Asp Pro Glu Pro Lys Lys Glu 
                645                 650                 655     


Pro Ala Gly His Ser Gln Lys Lys Gly Lys Ala Ile Asn Ile Gly Gln 
            660                 665                 670         


Leu Val Asp Val Lys Val Leu Glu Lys Thr Lys Asp Gly Leu Glu Val 
        675                 680                 685             


Ala Val Leu Pro His Asn Ile Arg Ala Phe Leu Pro Thr Ser His Leu 
    690                 695                 700                 


Ser Asp His Val Ala Asn Gly Pro Leu Leu His His Trp Leu Gln Ala 
705                 710                 715                 720 


Gly Asp Ile Leu His Arg Val Leu Cys Leu Ser Gln Ser Glu Gly Arg 
                725                 730                 735     


Val Leu Leu Cys Arg Lys Pro Ala Leu Val Ser Thr Val Glu Gly Gly 
            740                 745                 750         


Gln Asp Pro Lys Asn Phe Ser Glu Ile His Pro Gly Met Leu Leu Ile 
        755                 760                 765             


Gly Phe Val Lys Ser Ile Lys Asp Tyr Gly Val Phe Ile Gln Phe Pro 
    770                 775                 780                 


Ser Gly Leu Ser Gly Leu Ala Pro Lys Ala Ile Met Ser Asp Lys Phe 
785                 790                 795                 800 


Val Thr Ser Thr Ser Asp His Phe Val Glu Gly Gln Thr Val Ala Ala 
                805                 810                 815     


Lys Val Thr Asn Val Asp Glu Glu Lys Gln Arg Met Leu Leu Ser Leu 
            820                 825                 830         


Arg Leu Ser Asp Cys Gly Leu Gly Asp Leu Ala Ile Thr Ser Leu Leu 
        835                 840                 845             


Leu Leu Asn Gln Cys Leu Glu Glu Leu Gln Gly Val Arg Ser Leu Met 
    850                 855                 860                 


Ser Asn Arg Asp Ser Val Leu Ile Gln Thr Leu Ala Glu Met Thr Pro 
865                 870                 875                 880 


Gly Met Phe Leu Asp Leu Val Val Gln Glu Val Leu Glu Asp Gly Ser 
                885                 890                 895     


Val Val Phe Ser Gly Gly Pro Val Pro Asp Leu Val Leu Lys Ala Ser 
            900                 905                 910         


Arg Tyr His Arg Ala Gly Gln Glu Val Glu Ser Gly Gln Lys Lys Lys 
        915                 920                 925             


Val Val Ile Leu Asn Val Asp Leu Leu Lys Leu Glu Val His Val Ser 
    930                 935                 940                 


Leu His Gln Asp Leu Val Asn Arg Lys Ala Arg Lys Leu Arg Lys Gly 
945                 950                 955                 960 


Ser Glu His Gln Ala Ile Val Gln His Leu Glu Lys Ser Phe Ala Ile 
                965                 970                 975     


Ala Ser Leu Val Glu Thr Gly His Leu Ala Ala Phe Ser Leu Thr Ser 
            980                 985                 990         


His Leu Asn Asp Thr Phe Arg Phe  Asp Ser Glu Lys Leu  Gln Val Gly 
        995                 1000                 1005             


Gln Gly  Val Ser Leu Thr Leu  Lys Thr Thr Glu Pro  Gly Val Thr 
    1010                 1015                 1020             


Gly Leu  Leu Leu Ala Val Glu  Gly Pro Ala Ala Lys  Arg Thr Met 
    1025                 1030                 1035             


Arg Pro  Thr Gln Lys Asp Ser  Glu Thr Val Asp Glu  Asp Glu Glu 
    1040                 1045                 1050             


Val Asp  Pro Ala Leu Thr Val  Gly Thr Ile Lys Lys  His Thr Leu 
    1055                 1060                 1065             


Ser Ile  Gly Asp Met Val Thr  Gly Thr Val Lys Ser  Ile Lys Pro 
    1070                 1075                 1080             


Thr His  Val Val Val Thr Leu  Glu Asp Gly Ile Ile  Gly Cys Ile 
    1085                 1090                 1095             


His Ala  Ser His Ile Leu Asp  Asp Val Pro Glu Gly  Thr Ser Pro 
    1100                 1105                 1110             


Thr Thr  Lys Leu Lys Val Gly  Lys Thr Val Thr Ala  Arg Val Ile 
    1115                 1120                 1125             


Gly Gly  Arg Asp Met Lys Thr  Phe Lys Tyr Leu Pro  Ile Ser His 
    1130                 1135                 1140             


Pro Arg  Phe Val Arg Thr Ile  Pro Glu Leu Ser Val  Arg Pro Ser 
    1145                 1150                 1155             


Glu Leu  Glu Asp Gly His Thr  Ala Leu Asn Thr His  Ser Val Ser 
    1160                 1165                 1170             


Pro Met  Glu Lys Ile Lys Gln  Tyr Gln Ala Gly Gln  Thr Val Thr 
    1175                 1180                 1185             


Cys Phe  Leu Lys Lys Tyr Asn  Val Val Lys Lys Trp  Leu Glu Val 
    1190                 1195                 1200             


Glu Ile  Ala Pro Asp Ile Arg  Gly Arg Ile Pro Leu  Leu Leu Thr 
    1205                 1210                 1215             


Ser Leu  Ser Phe Lys Val Leu  Lys His Pro Asp Lys  Lys Phe Arg 
    1220                 1225                 1230             


Val Gly  Gln Ala Leu Arg Ala  Thr Val Val Gly Pro  Asp Ser Ser 
    1235                 1240                 1245             


Lys Thr  Leu Leu Cys Leu Ser  Leu Thr Gly Pro His  Lys Leu Glu 
    1250                 1255                 1260             


Glu Gly  Glu Val Ala Met Gly  Arg Val Val Lys Val  Thr Pro Asn 
    1265                 1270                 1275             


Glu Gly  Leu Thr Val Ser Phe  Pro Phe Gly Lys Ile  Gly Thr Val 
    1280                 1285                 1290             


Ser Ile  Phe His Met Ser Asp  Ser Tyr Ser Glu Thr  Pro Leu Glu 
    1295                 1300                 1305             


Asp Phe  Val Pro Gln Lys Val  Val Arg Cys Tyr Ile  Leu Ser Thr 
    1310                 1315                 1320             


Ala Asp  Asn Val Leu Thr Leu  Ser Leu Arg Ser Ser  Arg Thr Asn 
    1325                 1330                 1335             


Pro Glu  Thr Lys Ser Lys Val  Glu Asp Pro Glu Ile  Asn Ser Ile 
    1340                 1345                 1350             


Gln Asp  Ile Lys Glu Gly Gln  Leu Leu Arg Gly Tyr  Val Gly Ser 
    1355                 1360                 1365             


Ile Gln  Pro His Gly Val Phe  Phe Arg Leu Gly Pro  Ser Val Val 
    1370                 1375                 1380             


Gly Leu  Ala Arg Tyr Ser His  Val Ser Gln His Ser  Pro Ser Lys 
    1385                 1390                 1395             


Lys Ala  Leu Tyr Asn Lys His  Leu Pro Glu Gly Lys  Leu Leu Thr 
    1400                 1405                 1410             


Ala Arg  Val Leu Arg Leu Asn  His Gln Lys Asn Leu  Val Glu Leu 
    1415                 1420                 1425             


Ser Phe  Leu Pro Gly Asp Thr  Gly Lys Pro Asp Val  Leu Ser Ala 
    1430                 1435                 1440             


Ser Leu  Glu Gly Gln Leu Thr  Lys Gln Glu Glu Arg  Lys Thr Glu 
    1445                 1450                 1455             


Ala Glu  Glu Arg Asp Gln Lys  Gly Glu Lys Lys Asn  Gln Lys Arg 
    1460                 1465                 1470             


Asn Glu  Lys Lys Asn Gln Lys  Gly Gln Glu Glu Val  Glu Met Pro 
    1475                 1480                 1485             


Ser Lys  Glu Lys Gln Gln Pro  Gln Lys Pro Gln Ala  Gln Lys Arg 
    1490                 1495                 1500             


Gly Gly  Arg Glu Cys Arg Glu  Ser Gly Ser Glu Gln  Glu Arg Val 
    1505                 1510                 1515             


Ser Lys  Lys Pro Lys Lys Ala  Gly Leu Ser Glu Glu  Asp Asp Ser 
    1520                 1525                 1530             


Leu Val  Asp Val Tyr Tyr Arg  Glu Gly Lys Glu Glu  Ala Glu Glu 
    1535                 1540                 1545             


Thr Asn  Val Leu Pro Lys Glu  Lys Gln Thr Lys Pro  Ala Glu Ala 
    1550                 1555                 1560             


Pro Arg  Leu Gln Leu Ser Ser  Gly Phe Ala Trp Asn  Val Gly Leu 
    1565                 1570                 1575             


Asp Ser  Leu Thr Pro Ala Leu  Pro Pro Leu Ala Glu  Ser Ser Asp 
    1580                 1585                 1590             


Ser Glu  Glu Asp Glu Lys Pro  His Gln Ala Thr Ile  Lys Lys Ser 
    1595                 1600                 1605             


Lys Lys  Glu Arg Glu Leu Glu  Lys Gln Lys Ala Glu  Lys Glu Leu 
    1610                 1615                 1620             


Ser Arg  Ile Glu Glu Ala Leu  Met Asp Pro Gly Arg  Gln Pro Glu 
    1625                 1630                 1635             


Ser Ala  Asp Asp Phe Asp Arg  Leu Val Leu Ser Ser  Pro Asn Ser 
    1640                 1645                 1650             


Ser Ile  Leu Trp Leu Gln Tyr  Met Ala Phe His Leu  Gln Ala Thr 
    1655                 1660                 1665             


Glu Ile  Glu Lys Ala Arg Ala  Val Ala Glu Arg Ala  Leu Lys Thr 
    1670                 1675                 1680             


Ile Ser  Phe Arg Glu Glu Gln  Glu Lys Leu Asn Val  Trp Val Ala 
    1685                 1690                 1695             


Leu Leu  Asn Leu Glu Asn Met  Tyr Gly Ser Gln Glu  Ser Leu Thr 
    1700                 1705                 1710             


Lys Val  Phe Glu Arg Ala Val  Gln Tyr Asn Glu Pro  Leu Lys Val 
    1715                 1720                 1725             


Phe Leu  His Leu Ala Asp Ile  Tyr Ala Lys Ser Glu  Lys Phe Gln 
    1730                 1735                 1740             


Glu Ala  Gly Glu Leu Tyr Asn  Arg Met Leu Lys Arg  Phe Arg Gln 
    1745                 1750                 1755             


Glu Lys  Ala Val Trp Ile Lys  Tyr Gly Ala Phe Leu  Leu Arg Arg 
    1760                 1765                 1770             


Ser Gln  Ala Ala Ala Ser His  Arg Val Leu Gln Arg  Ala Leu Glu 
    1775                 1780                 1785             


Cys Leu  Pro Ser Lys Glu His  Val Asp Val Ile Ala  Lys Phe Ala 
    1790                 1795                 1800             


Gln Leu  Glu Phe Gln Leu Gly  Asp Ala Glu Arg Ala  Lys Ala Ile 
    1805                 1810                 1815             


Phe Glu  Asn Thr Leu Ser Thr  Tyr Pro Lys Arg Thr  Asp Val Trp 
    1820                 1825                 1830             


Ser Val  Tyr Ile Asp Met Thr  Ile Lys His Gly Ser  Gln Lys Asp 
    1835                 1840                 1845             


Val Arg  Asp Ile Phe Glu Arg  Val Ile His Leu Ser  Leu Ala Pro 
    1850                 1855                 1860             


Lys Arg  Met Lys Phe Phe Phe  Lys Arg Tyr Leu Asp  Tyr Glu Lys 
    1865                 1870                 1875             


Gln His  Gly Thr Glu Lys Asp  Val Gln Ala Val Lys  Ala Lys Ala 
    1880                 1885                 1890             


Leu Glu  Tyr Val Glu Ala Lys  Ser Ser Val Leu Glu  Asp 
    1895                 1900                 1905     


<210>  89
<211>  4276
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (392)..(3268)
<223>  

<400>  89
ggcttttctt ccccttctga ttttcccctc cccccttttc tccctttccg ggtttggttc     60

cccccttttc ttcccctctc ccccctcctt cccaagcccc tttcccctcc cccgtcccag    120

tcccccctgc ttcccagccc tcggccccgg ggaagccccg gccgagaaaa gcccgccccc    180

agaagcgcgc cgccgccggc cgtcggggcc gagccgcagc cgagcggccg tgggcccggg    240

cggcgggcgg agacgtgggc gccctccccg ccaaggcccg tgcgagaggt tagacttgtt    300

tcttatatgt gatgccattc cagcactgga ctcatggagg ctgagcattt attcaggagt    360

ccatagaggc cactgtattc tattgaagaa c atg tct aac agt aac act act       412
                                   Met Ser Asn Ser Asn Thr Thr          
                                   1               5                    

caa gag acc ctg gaa ata atg aaa gaa tca gaa aaa aaa ctg gtg gaa      460
Gln Glu Thr Leu Glu Ile Met Lys Glu Ser Glu Lys Lys Leu Val Glu         
        10                  15                  20                      

gaa tct gta aac aaa aac aag ttt ata tct aag act cca agt aag gaa      508
Glu Ser Val Asn Lys Asn Lys Phe Ile Ser Lys Thr Pro Ser Lys Glu         
    25                  30                  35                          

gaa att gag aaa gaa tgt gaa gat acc agt ttg cgt cag gag aca cag      556
Glu Ile Glu Lys Glu Cys Glu Asp Thr Ser Leu Arg Gln Glu Thr Gln         
40                  45                  50                  55          

agg cgg aca tct aac cat ggt cat gcc agg aaa aga gcc aag tct aat      604
Arg Arg Thr Ser Asn His Gly His Ala Arg Lys Arg Ala Lys Ser Asn         
                60                  65                  70              

tcc aag cta aag ttg gtg cgt agc ctg gca gtg tgt gag gag tcc tcc      652
Ser Lys Leu Lys Leu Val Arg Ser Leu Ala Val Cys Glu Glu Ser Ser         
            75                  80                  85                  

acc cca ttt gct gat ggg cca tta gaa acc cag gat ata att caa ttg      700
Thr Pro Phe Ala Asp Gly Pro Leu Glu Thr Gln Asp Ile Ile Gln Leu         
        90                  95                  100                     

cac atc agt tgc cct tct gac aag gag gaa gaa aag tcc aca aaa gat      748
His Ile Ser Cys Pro Ser Asp Lys Glu Glu Glu Lys Ser Thr Lys Asp         
    105                 110                 115                         

gtc tct gaa aag gaa gac aag gac aaa aac aaa gaa aag atc cca agg      796
Val Ser Glu Lys Glu Asp Lys Asp Lys Asn Lys Glu Lys Ile Pro Arg         
120                 125                 130                 135         

aag atg ctg tcc aga gac tcc agc cag gaa tat acg gac tcc act gga      844
Lys Met Leu Ser Arg Asp Ser Ser Gln Glu Tyr Thr Asp Ser Thr Gly         
                140                 145                 150             

ata gac cta cat gaa ttt ctt gta aat aca ctg aaa aag aac cca agg      892
Ile Asp Leu His Glu Phe Leu Val Asn Thr Leu Lys Lys Asn Pro Arg         
            155                 160                 165                 

gac aga atg atg ctg cta aaa tta gaa cag gag att ctg gaa ttt att      940
Asp Arg Met Met Leu Leu Lys Leu Glu Gln Glu Ile Leu Glu Phe Ile         
        170                 175                 180                     

aat gac aac aat aat cag ttc aag aag ttc cct cag atg acc tca tat      988
Asn Asp Asn Asn Asn Gln Phe Lys Lys Phe Pro Gln Met Thr Ser Tyr         
    185                 190                 195                         

cac cgg atg cta tta cac cgg gta gct gcc tat ttt ggg atg gac cac     1036
His Arg Met Leu Leu His Arg Val Ala Ala Tyr Phe Gly Met Asp His         
200                 205                 210                 215         

aat gtt gat caa act ggg aaa gct gtc atc atc aac aaa act agt aac     1084
Asn Val Asp Gln Thr Gly Lys Ala Val Ile Ile Asn Lys Thr Ser Asn         
                220                 225                 230             

aca aga atc cct gaa cag agg ttc tca gaa cat ata aag gat gag aag     1132
Thr Arg Ile Pro Glu Gln Arg Phe Ser Glu His Ile Lys Asp Glu Lys         
            235                 240                 245                 

aat aca gaa ttt caa cag agg ttc att ctc aag aga gat gat gcc agt     1180
Asn Thr Glu Phe Gln Gln Arg Phe Ile Leu Lys Arg Asp Asp Ala Ser         
        250                 255                 260                     

atg gac cga gat gat aac cag act ggc cag aac gga tat cta aat gac     1228
Met Asp Arg Asp Asp Asn Gln Thr Gly Gln Asn Gly Tyr Leu Asn Asp         
    265                 270                 275                         

atc agg ggg aac cgt gaa gga ctg agc cgc acc tca agc agc cgc cag     1276
Ile Arg Gly Asn Arg Glu Gly Leu Ser Arg Thr Ser Ser Ser Arg Gln         
280                 285                 290                 295         

agc agc aca gac agc gaa ctc aaa tcc ctg gag cca cgc cct tgg agc     1324
Ser Ser Thr Asp Ser Glu Leu Lys Ser Leu Glu Pro Arg Pro Trp Ser         
                300                 305                 310             

agc aca gac tct gat ggc tct gtc cgg agc atg cga ccc cct gtc acc     1372
Ser Thr Asp Ser Asp Gly Ser Val Arg Ser Met Arg Pro Pro Val Thr         
            315                 320                 325                 

aaa gct agc agc ttc agt gga atc tct atc ctt acc cga ggt gac agc     1420
Lys Ala Ser Ser Phe Ser Gly Ile Ser Ile Leu Thr Arg Gly Asp Ser         
        330                 335                 340                     

atc ggc agc agt aaa ggc ggc agt gcg gga agg atc tcc agg cca ggt     1468
Ile Gly Ser Ser Lys Gly Gly Ser Ala Gly Arg Ile Ser Arg Pro Gly         
    345                 350                 355                         

atg gca cta ggt gcc cca gaa gtg tgc aac cag gtc acc tca tcc cag     1516
Met Ala Leu Gly Ala Pro Glu Val Cys Asn Gln Val Thr Ser Ser Gln         
360                 365                 370                 375         

tct gtc cgg ggg ctt ctc cct tgt act gcc cag cag caa cag cag cag     1564
Ser Val Arg Gly Leu Leu Pro Cys Thr Ala Gln Gln Gln Gln Gln Gln         
                380                 385                 390             

cag cag cag caa ctt cct gct ctc cca ccc acg cct cag caa cag cca     1612
Gln Gln Gln Gln Leu Pro Ala Leu Pro Pro Thr Pro Gln Gln Gln Pro         
            395                 400                 405                 

ccc ttg aat aat cac atg atc tca cag gca gat gac ctc agc aac ccc     1660
Pro Leu Asn Asn His Met Ile Ser Gln Ala Asp Asp Leu Ser Asn Pro         
        410                 415                 420                     

ttt gga caa atg agc ctt agt cgc caa ggt tct act gaa gca gct gac     1708
Phe Gly Gln Met Ser Leu Ser Arg Gln Gly Ser Thr Glu Ala Ala Asp         
    425                 430                 435                         

cca tct gca gct cta ttc cag acc cca ctt atc tcc cag cac cct cag     1756
Pro Ser Ala Ala Leu Phe Gln Thr Pro Leu Ile Ser Gln His Pro Gln         
440                 445                 450                 455         

cag act agc ttc atc atg gct tcc acg ggt cag ccc ctc ccc act tcc     1804
Gln Thr Ser Phe Ile Met Ala Ser Thr Gly Gln Pro Leu Pro Thr Ser         
                460                 465                 470             

aac tat tcc acc tct agc cat gca cca cct act cag caa gtt ctg cca     1852
Asn Tyr Ser Thr Ser Ser His Ala Pro Pro Thr Gln Gln Val Leu Pro         
            475                 480                 485                 

ccc cag ggg tac atg cag ccc cct caa cag atc cag gtt tct tac tat     1900
Pro Gln Gly Tyr Met Gln Pro Pro Gln Gln Ile Gln Val Ser Tyr Tyr         
        490                 495                 500                     

ccc cct gga caa tat cct aac tcc aac cag caa tat cga cct ctc tct     1948
Pro Pro Gly Gln Tyr Pro Asn Ser Asn Gln Gln Tyr Arg Pro Leu Ser         
    505                 510                 515                         

cac ccg gtg gcc tat agc ccc caa cgt ggt cag cag ctg cct cag cca     1996
His Pro Val Ala Tyr Ser Pro Gln Arg Gly Gln Gln Leu Pro Gln Pro         
520                 525                 530                 535         

tcc cag cag cct ggt tta cag ccc atg atg cct aac cag cag cag gcg     2044
Ser Gln Gln Pro Gly Leu Gln Pro Met Met Pro Asn Gln Gln Gln Ala         
                540                 545                 550             

gct tac caa ggc atg att ggg gtc cag cag cca cag aac cag ggc ctg     2092
Ala Tyr Gln Gly Met Ile Gly Val Gln Gln Pro Gln Asn Gln Gly Leu         
            555                 560                 565                 

ctc agc agc cag agg agc agc atg ggg ggc cag atg caa ggc ctg gtg     2140
Leu Ser Ser Gln Arg Ser Ser Met Gly Gly Gln Met Gln Gly Leu Val         
        570                 575                 580                     

gtt cag tac act cca ctg cct tct tac caa gtt cca gtg ggt agt gac     2188
Val Gln Tyr Thr Pro Leu Pro Ser Tyr Gln Val Pro Val Gly Ser Asp         
    585                 590                 595                         

tcg caa aat gtg gtc cag ccg cct ttc cag caa ccc atg ctg gtc cct     2236
Ser Gln Asn Val Val Gln Pro Pro Phe Gln Gln Pro Met Leu Val Pro         
600                 605                 610                 615         

gtg agc cag tct gtg caa gga ggc ctc cca gca gcg ggg gta cca gtg     2284
Val Ser Gln Ser Val Gln Gly Gly Leu Pro Ala Ala Gly Val Pro Val         
                620                 625                 630             

tac tat agc atg atc cca cct gct cag cag aac ggt acg agc cct tct     2332
Tyr Tyr Ser Met Ile Pro Pro Ala Gln Gln Asn Gly Thr Ser Pro Ser         
            635                 640                 645                 

gta ggg ttt ctg caa ccc cct ggc tct gag cag tac cag atg cct cag     2380
Val Gly Phe Leu Gln Pro Pro Gly Ser Glu Gln Tyr Gln Met Pro Gln         
        650                 655                 660                     

tct ccc tct ccc tgc agt cca cca cag atg cca cag cag tac tca gga     2428
Ser Pro Ser Pro Cys Ser Pro Pro Gln Met Pro Gln Gln Tyr Ser Gly         
    665                 670                 675                         

gtg tca cct tct gga cca ggt gta gtg gtc atg cag ctg aat gtc cct     2476
Val Ser Pro Ser Gly Pro Gly Val Val Val Met Gln Leu Asn Val Pro         
680                 685                 690                 695         

aat gga ccc cag ccc cct cag aac cca tcc atg gtc cag tgg agt cat     2524
Asn Gly Pro Gln Pro Pro Gln Asn Pro Ser Met Val Gln Trp Ser His         
                700                 705                 710             

tgt aaa tac tac agc atg gac cag cgg ggg cag aag cct gga gac ctg     2572
Cys Lys Tyr Tyr Ser Met Asp Gln Arg Gly Gln Lys Pro Gly Asp Leu         
            715                 720                 725                 

tac agt cct gac agc agc ccc cag gcc aac aca caa atg agc agc agc     2620
Tyr Ser Pro Asp Ser Ser Pro Gln Ala Asn Thr Gln Met Ser Ser Ser         
        730                 735                 740                     

cct gtc aca tct cct acc cag tct cca gca ccc tct cct gtc acc agc     2668
Pro Val Thr Ser Pro Thr Gln Ser Pro Ala Pro Ser Pro Val Thr Ser         
    745                 750                 755                         

ctc agc agt gtc tgc aca gga ctc agt ccc ctg cct gtc ctc aca cag     2716
Leu Ser Ser Val Cys Thr Gly Leu Ser Pro Leu Pro Val Leu Thr Gln         
760                 765                 770                 775         

ttc ccc cgg cct ggg ggt cca gca cag ggt gat ggg cgc tac tcc ctt     2764
Phe Pro Arg Pro Gly Gly Pro Ala Gln Gly Asp Gly Arg Tyr Ser Leu         
                780                 785                 790             

ttg ggc cag cca tta cag tac aat ctg tcc atc tgc cct ccc ttg ctc     2812
Leu Gly Gln Pro Leu Gln Tyr Asn Leu Ser Ile Cys Pro Pro Leu Leu         
            795                 800                 805                 

cat ggc cag tca act tac acg gtg cac cag gga cag agt gga ctg aag     2860
His Gly Gln Ser Thr Tyr Thr Val His Gln Gly Gln Ser Gly Leu Lys         
        810                 815                 820                     

cat gga aac cgg ggc aag aga caa gca ctc aaa tct gcc tcc act gac     2908
His Gly Asn Arg Gly Lys Arg Gln Ala Leu Lys Ser Ala Ser Thr Asp         
    825                 830                 835                         

ctg ggg aca gca gat gtt gtc ctg ggg cgg gtg ctg gag gtg aca gat     2956
Leu Gly Thr Ala Asp Val Val Leu Gly Arg Val Leu Glu Val Thr Asp         
840                 845                 850                 855         

ctc cct gag ggc atc acc cgt act gag gcg gac aaa ctc ttc acg cag     3004
Leu Pro Glu Gly Ile Thr Arg Thr Glu Ala Asp Lys Leu Phe Thr Gln         
                860                 865                 870             

ctc gcc atg tct ggc gcc aag atc cag tgg ctc aag gat gct cag ggg     3052
Leu Ala Met Ser Gly Ala Lys Ile Gln Trp Leu Lys Asp Ala Gln Gly         
            875                 880                 885                 

ctg cct gga ggg ggt ggg ggg gac aac agt ggg act gct gag aat ggc     3100
Leu Pro Gly Gly Gly Gly Gly Asp Asn Ser Gly Thr Ala Glu Asn Gly         
        890                 895                 900                     

cgc cac tcg gac ctc gct gcc ttg tac acc att gtg gct gtg ttc ccc     3148
Arg His Ser Asp Leu Ala Ala Leu Tyr Thr Ile Val Ala Val Phe Pro         
    905                 910                 915                         

agc ccc ctg gct gcc caa aat gcc tcc ctt cgt ctc aac aac tcc gtg     3196
Ser Pro Leu Ala Ala Gln Asn Ala Ser Leu Arg Leu Asn Asn Ser Val         
920                 925                 930                 935         

agt cgc ttc aaa ctt cga atg gcc aaa aag aac tat gac ctg agg atc     3244
Ser Arg Phe Lys Leu Arg Met Ala Lys Lys Asn Tyr Asp Leu Arg Ile         
                940                 945                 950             

ctg gag cga gcc agc tcc caa taa atggaggagg ggaaagggac tgtcacagaa    3298
Leu Glu Arg Ala Ser Ser Gln                                             
            955                                                         

gaagcaaggg cagggtggag ggggttgaag gatcctgaca gaccatggac agaggcagga   3358

agtaaggaaa ctgatgttaa actggaacct aagacagtga tgaagatgga aacacagata   3418

cctacactgg cattggactc cttcttgctc ccctgccatg ggtcctctct ttttccctgg   3478

ttgacccccc ttgcatcact cttcttccca tcctcttctt tttttttttt tttttttttt   3538

tgagacggag tttcgctctt gtcaccccag ctggagtgca gtagcacgat cttggctaac   3598

tgcaacctcc agctcctggg ttcaggtgat tctcctgcct cagcctccca agtagctggc   3658

actacagaca cgcgccacca tgcccggcta atttttgtat ttttagtaga gacggagttt   3718

caccatgttg gccaggctgg cctcaaactc ctgacctcag gtgatccacc tgccttggcc   3778

ttccagagtg ctgggattac aggcgtgagc cactgtgcct ggcttccatc ctcttctatc   3838

atttttttaa atctcttctc ctatcataaa attaatttct cattttttgg tcaggtagaa   3898

ttgggaaagt cccacactgt cctcctatta ccttaacatc ccaagcttcc tttccttttt   3958

tggtctttat gaatatattt atatggacag aattaagata aacaaaattg attgccccat   4018

tctctcactt ccccatcttg tcttcctaga ccccacagag ttaaaacttg ggattcccct   4078

ggccccccca gaacacttgt atattgtttg tttgaggttc gtgccgcagt aacagacaca   4138

gtatttaatt gcacatacag atgtttgctg ggtatattca ctgtaaattt tatttaatct   4198

gtttttttgt ttgtttgggg gttatttggg gggaggttgg ttttgttttt aaatataaaa   4258

aaaaaaatct gtcactgg                                                 4276


<210>  90
<211>  958
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ser Asn Ser Asn Thr Thr Gln Glu Thr Leu Glu Ile Met Lys Glu 
1               5                   10                  15      


Ser Glu Lys Lys Leu Val Glu Glu Ser Val Asn Lys Asn Lys Phe Ile 
            20                  25                  30          


Ser Lys Thr Pro Ser Lys Glu Glu Ile Glu Lys Glu Cys Glu Asp Thr 
        35                  40                  45              


Ser Leu Arg Gln Glu Thr Gln Arg Arg Thr Ser Asn His Gly His Ala 
    50                  55                  60                  


Arg Lys Arg Ala Lys Ser Asn Ser Lys Leu Lys Leu Val Arg Ser Leu 
65                  70                  75                  80  


Ala Val Cys Glu Glu Ser Ser Thr Pro Phe Ala Asp Gly Pro Leu Glu 
                85                  90                  95      


Thr Gln Asp Ile Ile Gln Leu His Ile Ser Cys Pro Ser Asp Lys Glu 
            100                 105                 110         


Glu Glu Lys Ser Thr Lys Asp Val Ser Glu Lys Glu Asp Lys Asp Lys 
        115                 120                 125             


Asn Lys Glu Lys Ile Pro Arg Lys Met Leu Ser Arg Asp Ser Ser Gln 
    130                 135                 140                 


Glu Tyr Thr Asp Ser Thr Gly Ile Asp Leu His Glu Phe Leu Val Asn 
145                 150                 155                 160 


Thr Leu Lys Lys Asn Pro Arg Asp Arg Met Met Leu Leu Lys Leu Glu 
                165                 170                 175     


Gln Glu Ile Leu Glu Phe Ile Asn Asp Asn Asn Asn Gln Phe Lys Lys 
            180                 185                 190         


Phe Pro Gln Met Thr Ser Tyr His Arg Met Leu Leu His Arg Val Ala 
        195                 200                 205             


Ala Tyr Phe Gly Met Asp His Asn Val Asp Gln Thr Gly Lys Ala Val 
    210                 215                 220                 


Ile Ile Asn Lys Thr Ser Asn Thr Arg Ile Pro Glu Gln Arg Phe Ser 
225                 230                 235                 240 


Glu His Ile Lys Asp Glu Lys Asn Thr Glu Phe Gln Gln Arg Phe Ile 
                245                 250                 255     


Leu Lys Arg Asp Asp Ala Ser Met Asp Arg Asp Asp Asn Gln Thr Gly 
            260                 265                 270         


Gln Asn Gly Tyr Leu Asn Asp Ile Arg Gly Asn Arg Glu Gly Leu Ser 
        275                 280                 285             


Arg Thr Ser Ser Ser Arg Gln Ser Ser Thr Asp Ser Glu Leu Lys Ser 
    290                 295                 300                 


Leu Glu Pro Arg Pro Trp Ser Ser Thr Asp Ser Asp Gly Ser Val Arg 
305                 310                 315                 320 


Ser Met Arg Pro Pro Val Thr Lys Ala Ser Ser Phe Ser Gly Ile Ser 
                325                 330                 335     


Ile Leu Thr Arg Gly Asp Ser Ile Gly Ser Ser Lys Gly Gly Ser Ala 
            340                 345                 350         


Gly Arg Ile Ser Arg Pro Gly Met Ala Leu Gly Ala Pro Glu Val Cys 
        355                 360                 365             


Asn Gln Val Thr Ser Ser Gln Ser Val Arg Gly Leu Leu Pro Cys Thr 
    370                 375                 380                 


Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu Pro Ala Leu Pro 
385                 390                 395                 400 


Pro Thr Pro Gln Gln Gln Pro Pro Leu Asn Asn His Met Ile Ser Gln 
                405                 410                 415     


Ala Asp Asp Leu Ser Asn Pro Phe Gly Gln Met Ser Leu Ser Arg Gln 
            420                 425                 430         


Gly Ser Thr Glu Ala Ala Asp Pro Ser Ala Ala Leu Phe Gln Thr Pro 
        435                 440                 445             


Leu Ile Ser Gln His Pro Gln Gln Thr Ser Phe Ile Met Ala Ser Thr 
    450                 455                 460                 


Gly Gln Pro Leu Pro Thr Ser Asn Tyr Ser Thr Ser Ser His Ala Pro 
465                 470                 475                 480 


Pro Thr Gln Gln Val Leu Pro Pro Gln Gly Tyr Met Gln Pro Pro Gln 
                485                 490                 495     


Gln Ile Gln Val Ser Tyr Tyr Pro Pro Gly Gln Tyr Pro Asn Ser Asn 
            500                 505                 510         


Gln Gln Tyr Arg Pro Leu Ser His Pro Val Ala Tyr Ser Pro Gln Arg 
        515                 520                 525             


Gly Gln Gln Leu Pro Gln Pro Ser Gln Gln Pro Gly Leu Gln Pro Met 
    530                 535                 540                 


Met Pro Asn Gln Gln Gln Ala Ala Tyr Gln Gly Met Ile Gly Val Gln 
545                 550                 555                 560 


Gln Pro Gln Asn Gln Gly Leu Leu Ser Ser Gln Arg Ser Ser Met Gly 
                565                 570                 575     


Gly Gln Met Gln Gly Leu Val Val Gln Tyr Thr Pro Leu Pro Ser Tyr 
            580                 585                 590         


Gln Val Pro Val Gly Ser Asp Ser Gln Asn Val Val Gln Pro Pro Phe 
        595                 600                 605             


Gln Gln Pro Met Leu Val Pro Val Ser Gln Ser Val Gln Gly Gly Leu 
    610                 615                 620                 


Pro Ala Ala Gly Val Pro Val Tyr Tyr Ser Met Ile Pro Pro Ala Gln 
625                 630                 635                 640 


Gln Asn Gly Thr Ser Pro Ser Val Gly Phe Leu Gln Pro Pro Gly Ser 
                645                 650                 655     


Glu Gln Tyr Gln Met Pro Gln Ser Pro Ser Pro Cys Ser Pro Pro Gln 
            660                 665                 670         


Met Pro Gln Gln Tyr Ser Gly Val Ser Pro Ser Gly Pro Gly Val Val 
        675                 680                 685             


Val Met Gln Leu Asn Val Pro Asn Gly Pro Gln Pro Pro Gln Asn Pro 
    690                 695                 700                 


Ser Met Val Gln Trp Ser His Cys Lys Tyr Tyr Ser Met Asp Gln Arg 
705                 710                 715                 720 


Gly Gln Lys Pro Gly Asp Leu Tyr Ser Pro Asp Ser Ser Pro Gln Ala 
                725                 730                 735     


Asn Thr Gln Met Ser Ser Ser Pro Val Thr Ser Pro Thr Gln Ser Pro 
            740                 745                 750         


Ala Pro Ser Pro Val Thr Ser Leu Ser Ser Val Cys Thr Gly Leu Ser 
        755                 760                 765             


Pro Leu Pro Val Leu Thr Gln Phe Pro Arg Pro Gly Gly Pro Ala Gln 
    770                 775                 780                 


Gly Asp Gly Arg Tyr Ser Leu Leu Gly Gln Pro Leu Gln Tyr Asn Leu 
785                 790                 795                 800 


Ser Ile Cys Pro Pro Leu Leu His Gly Gln Ser Thr Tyr Thr Val His 
                805                 810                 815     


Gln Gly Gln Ser Gly Leu Lys His Gly Asn Arg Gly Lys Arg Gln Ala 
            820                 825                 830         


Leu Lys Ser Ala Ser Thr Asp Leu Gly Thr Ala Asp Val Val Leu Gly 
        835                 840                 845             


Arg Val Leu Glu Val Thr Asp Leu Pro Glu Gly Ile Thr Arg Thr Glu 
    850                 855                 860                 


Ala Asp Lys Leu Phe Thr Gln Leu Ala Met Ser Gly Ala Lys Ile Gln 
865                 870                 875                 880 


Trp Leu Lys Asp Ala Gln Gly Leu Pro Gly Gly Gly Gly Gly Asp Asn 
                885                 890                 895     


Ser Gly Thr Ala Glu Asn Gly Arg His Ser Asp Leu Ala Ala Leu Tyr 
            900                 905                 910         


Thr Ile Val Ala Val Phe Pro Ser Pro Leu Ala Ala Gln Asn Ala Ser 
        915                 920                 925             


Leu Arg Leu Asn Asn Ser Val Ser Arg Phe Lys Leu Arg Met Ala Lys 
    930                 935                 940                 


Lys Asn Tyr Asp Leu Arg Ile Leu Glu Arg Ala Ser Ser Gln 
945                 950                 955             


<210>  91
<211>  4330
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (392)..(3322)
<223>  

<400>  91
ggcttttctt ccccttctga ttttcccctc cccccttttc tccctttccg ggtttggttc     60

cccccttttc ttcccctctc ccccctcctt cccaagcccc tttcccctcc cccgtcccag    120

tcccccctgc ttcccagccc tcggccccgg ggaagccccg gccgagaaaa gcccgccccc    180

agaagcgcgc cgccgccggc cgtcggggcc gagccgcagc cgagcggccg tgggcccggg    240

cggcgggcgg agacgtgggc gccctccccg ccaaggcccg tgcgagaggt tagacttgtt    300

tcttatatgt gatgccattc cagcactgga ctcatggagg ctgagcattt attcaggagt    360

ccatagaggc cactgtattc tattgaagaa c atg tct aac agt aac act act       412
                                   Met Ser Asn Ser Asn Thr Thr          
                                   1               5                    

caa gag acc ctg gaa ata atg aaa gaa tca gaa aaa aaa ctg gtg gaa      460
Gln Glu Thr Leu Glu Ile Met Lys Glu Ser Glu Lys Lys Leu Val Glu         
        10                  15                  20                      

gaa tct gta aac aaa aac aag ttt ata tct aag act cca agt aag gaa      508
Glu Ser Val Asn Lys Asn Lys Phe Ile Ser Lys Thr Pro Ser Lys Glu         
    25                  30                  35                          

gaa att gag aaa gaa tgt gaa gat acc agt ttg cgt cag gag aca cag      556
Glu Ile Glu Lys Glu Cys Glu Asp Thr Ser Leu Arg Gln Glu Thr Gln         
40                  45                  50                  55          

agg cgg aca tct aac cat ggt cat gcc agg aaa aga gcc aag tct aat      604
Arg Arg Thr Ser Asn His Gly His Ala Arg Lys Arg Ala Lys Ser Asn         
                60                  65                  70              

tcc aag cta aag ttg gtg cgt agc ctg gca gtg tgt gag gag tcc tcc      652
Ser Lys Leu Lys Leu Val Arg Ser Leu Ala Val Cys Glu Glu Ser Ser         
            75                  80                  85                  

acc cca ttt gct gat ggg cca tta gaa acc cag gat ata att caa ttg      700
Thr Pro Phe Ala Asp Gly Pro Leu Glu Thr Gln Asp Ile Ile Gln Leu         
        90                  95                  100                     

cac atc agt tgc cct tct gac aag gag gaa gaa aag tcc aca aaa gat      748
His Ile Ser Cys Pro Ser Asp Lys Glu Glu Glu Lys Ser Thr Lys Asp         
    105                 110                 115                         

gtc tct gaa aag gaa gac aag gac aaa aac aaa gaa aag atc cca agg      796
Val Ser Glu Lys Glu Asp Lys Asp Lys Asn Lys Glu Lys Ile Pro Arg         
120                 125                 130                 135         

aag atg ctg tcc aga gac tcc agc cag gaa tat acg gac tcc act gga      844
Lys Met Leu Ser Arg Asp Ser Ser Gln Glu Tyr Thr Asp Ser Thr Gly         
                140                 145                 150             

ata gac cta cat gaa ttt ctt gta aat aca ctg aaa aag aac cca agg      892
Ile Asp Leu His Glu Phe Leu Val Asn Thr Leu Lys Lys Asn Pro Arg         
            155                 160                 165                 

gac aga atg atg ctg cta aaa tta gaa cag gag att ctg gaa ttt att      940
Asp Arg Met Met Leu Leu Lys Leu Glu Gln Glu Ile Leu Glu Phe Ile         
        170                 175                 180                     

aat gac aac aat aat cag ttc aag aag ttc cct cag atg acc tca tat      988
Asn Asp Asn Asn Asn Gln Phe Lys Lys Phe Pro Gln Met Thr Ser Tyr         
    185                 190                 195                         

cac cgg atg cta tta cac cgg gta gct gcc tat ttt ggg atg gac cac     1036
His Arg Met Leu Leu His Arg Val Ala Ala Tyr Phe Gly Met Asp His         
200                 205                 210                 215         

aat gtt gat caa act ggg aaa gct gtc atc atc aac aaa act agt aac     1084
Asn Val Asp Gln Thr Gly Lys Ala Val Ile Ile Asn Lys Thr Ser Asn         
                220                 225                 230             

aca aga atc cct gaa cag agg ttc tca gaa cat ata aag gat gag aag     1132
Thr Arg Ile Pro Glu Gln Arg Phe Ser Glu His Ile Lys Asp Glu Lys         
            235                 240                 245                 

aat aca gaa ttt caa cag agg ttc att ctc aag aga gat gat gcc agt     1180
Asn Thr Glu Phe Gln Gln Arg Phe Ile Leu Lys Arg Asp Asp Ala Ser         
        250                 255                 260                     

atg gac cga gat gat aac cag act ggc cag aac gga tat cta aat gac     1228
Met Asp Arg Asp Asp Asn Gln Thr Gly Gln Asn Gly Tyr Leu Asn Asp         
    265                 270                 275                         

atc aga ctc tcc aaa gaa gcc ttt tct tct agc tct cac aag aga agg     1276
Ile Arg Leu Ser Lys Glu Ala Phe Ser Ser Ser Ser His Lys Arg Arg         
280                 285                 290                 295         

cag att ttt agg ggg aac cgt gaa gga ctg agc cgc acc tca agc agc     1324
Gln Ile Phe Arg Gly Asn Arg Glu Gly Leu Ser Arg Thr Ser Ser Ser         
                300                 305                 310             

cgc cag agc agc aca gac agc gaa ctc aaa tcc ctg gag cca cgc cct     1372
Arg Gln Ser Ser Thr Asp Ser Glu Leu Lys Ser Leu Glu Pro Arg Pro         
            315                 320                 325                 

tgg agc agc aca gac tct gat ggc tct gtc cgg agc atg cga ccc cct     1420
Trp Ser Ser Thr Asp Ser Asp Gly Ser Val Arg Ser Met Arg Pro Pro         
        330                 335                 340                     

gtc acc aaa gct agc agc ttc agt gga atc tct atc ctt acc cga ggt     1468
Val Thr Lys Ala Ser Ser Phe Ser Gly Ile Ser Ile Leu Thr Arg Gly         
    345                 350                 355                         

gac agc atc ggc agc agt aaa ggc ggc agt gcg gga agg atc tcc agg     1516
Asp Ser Ile Gly Ser Ser Lys Gly Gly Ser Ala Gly Arg Ile Ser Arg         
360                 365                 370                 375         

cca ggt atg gca cta ggt gcc cca gaa gtg tgc aac cag gtc acc tca     1564
Pro Gly Met Ala Leu Gly Ala Pro Glu Val Cys Asn Gln Val Thr Ser         
                380                 385                 390             

tcc cag tct gtc cgg ggg ctt ctc cct tgt act gcc cag cag caa cag     1612
Ser Gln Ser Val Arg Gly Leu Leu Pro Cys Thr Ala Gln Gln Gln Gln         
            395                 400                 405                 

cag cag cag cag cag caa ctt cct gct ctc cca ccc acg cct cag caa     1660
Gln Gln Gln Gln Gln Gln Leu Pro Ala Leu Pro Pro Thr Pro Gln Gln         
        410                 415                 420                     

cag cca ccc ttg aat aat cac atg atc tca cag gca gat gac ctc agc     1708
Gln Pro Pro Leu Asn Asn His Met Ile Ser Gln Ala Asp Asp Leu Ser         
    425                 430                 435                         

aac ccc ttt gga caa atg agc ctt agt cgc caa ggt tct act gaa gca     1756
Asn Pro Phe Gly Gln Met Ser Leu Ser Arg Gln Gly Ser Thr Glu Ala         
440                 445                 450                 455         

gct gac cca tct gca gct cta ttc cag acc cca ctt atc tcc cag cac     1804
Ala Asp Pro Ser Ala Ala Leu Phe Gln Thr Pro Leu Ile Ser Gln His         
                460                 465                 470             

cct cag cag act agc ttc atc atg gct tcc acg ggt cag ccc ctc ccc     1852
Pro Gln Gln Thr Ser Phe Ile Met Ala Ser Thr Gly Gln Pro Leu Pro         
            475                 480                 485                 

act tcc aac tat tcc acc tct agc cat gca cca cct act cag caa gtt     1900
Thr Ser Asn Tyr Ser Thr Ser Ser His Ala Pro Pro Thr Gln Gln Val         
        490                 495                 500                     

ctg cca ccc cag ggg tac atg cag ccc cct caa cag atc cag gtt tct     1948
Leu Pro Pro Gln Gly Tyr Met Gln Pro Pro Gln Gln Ile Gln Val Ser         
    505                 510                 515                         

tac tat ccc cct gga caa tat cct aac tcc aac cag caa tat cga cct     1996
Tyr Tyr Pro Pro Gly Gln Tyr Pro Asn Ser Asn Gln Gln Tyr Arg Pro         
520                 525                 530                 535         

ctc tct cac ccg gtg gcc tat agc ccc caa cgt ggt cag cag ctg cct     2044
Leu Ser His Pro Val Ala Tyr Ser Pro Gln Arg Gly Gln Gln Leu Pro         
                540                 545                 550             

cag cca tcc cag cag cct ggt tta cag ccc atg atg cct aac cag cag     2092
Gln Pro Ser Gln Gln Pro Gly Leu Gln Pro Met Met Pro Asn Gln Gln         
            555                 560                 565                 

cag gcg gct tac caa ggc atg att ggg gtc cag cag cca cag aac cag     2140
Gln Ala Ala Tyr Gln Gly Met Ile Gly Val Gln Gln Pro Gln Asn Gln         
        570                 575                 580                     

ggc ctg ctc agc agc cag agg agc agc atg ggg ggc cag atg caa ggc     2188
Gly Leu Leu Ser Ser Gln Arg Ser Ser Met Gly Gly Gln Met Gln Gly         
    585                 590                 595                         

ctg gtg gtt cag tac act cca ctg cct tct tac caa gtt cca gtg ggt     2236
Leu Val Val Gln Tyr Thr Pro Leu Pro Ser Tyr Gln Val Pro Val Gly         
600                 605                 610                 615         

agt gac tcg caa aat gtg gtc cag ccg cct ttc cag caa ccc atg ctg     2284
Ser Asp Ser Gln Asn Val Val Gln Pro Pro Phe Gln Gln Pro Met Leu         
                620                 625                 630             

gtc cct gtg agc cag tct gtg caa gga ggc ctc cca gca gcg ggg gta     2332
Val Pro Val Ser Gln Ser Val Gln Gly Gly Leu Pro Ala Ala Gly Val         
            635                 640                 645                 

cca gtg tac tat agc atg atc cca cct gct cag cag aac ggt acg agc     2380
Pro Val Tyr Tyr Ser Met Ile Pro Pro Ala Gln Gln Asn Gly Thr Ser         
        650                 655                 660                     

cct tct gta ggg ttt ctg caa ccc cct ggc tct gag cag tac cag atg     2428
Pro Ser Val Gly Phe Leu Gln Pro Pro Gly Ser Glu Gln Tyr Gln Met         
    665                 670                 675                         

cct cag tct ccc tct ccc tgc agt cca cca cag atg cca cag cag tac     2476
Pro Gln Ser Pro Ser Pro Cys Ser Pro Pro Gln Met Pro Gln Gln Tyr         
680                 685                 690                 695         

tca gga gtg tca cct tct gga cca ggt gta gtg gtc atg cag ctg aat     2524
Ser Gly Val Ser Pro Ser Gly Pro Gly Val Val Val Met Gln Leu Asn         
                700                 705                 710             

gtc cct aat gga ccc cag ccc cct cag aac cca tcc atg gtc cag tgg     2572
Val Pro Asn Gly Pro Gln Pro Pro Gln Asn Pro Ser Met Val Gln Trp         
            715                 720                 725                 

agt cat tgt aaa tac tac agc atg gac cag cgg ggg cag aag cct gga     2620
Ser His Cys Lys Tyr Tyr Ser Met Asp Gln Arg Gly Gln Lys Pro Gly         
        730                 735                 740                     

gac ctg tac agt cct gac agc agc ccc cag gcc aac aca caa atg agc     2668
Asp Leu Tyr Ser Pro Asp Ser Ser Pro Gln Ala Asn Thr Gln Met Ser         
    745                 750                 755                         

agc agc cct gtc aca tct cct acc cag tct cca gca ccc tct cct gtc     2716
Ser Ser Pro Val Thr Ser Pro Thr Gln Ser Pro Ala Pro Ser Pro Val         
760                 765                 770                 775         

acc agc ctc agc agt gtc tgc aca gga ctc agt ccc ctg cct gtc ctc     2764
Thr Ser Leu Ser Ser Val Cys Thr Gly Leu Ser Pro Leu Pro Val Leu         
                780                 785                 790             

aca cag ttc ccc cgg cct ggg ggt cca gca cag ggt gat ggg cgc tac     2812
Thr Gln Phe Pro Arg Pro Gly Gly Pro Ala Gln Gly Asp Gly Arg Tyr         
            795                 800                 805                 

tcc ctt ttg ggc cag cca tta cag tac aat ctg tcc atc tgc cct ccc     2860
Ser Leu Leu Gly Gln Pro Leu Gln Tyr Asn Leu Ser Ile Cys Pro Pro         
        810                 815                 820                     

ttg ctc cat ggc cag tca act tac acg gtg cac cag gga cag agt gga     2908
Leu Leu His Gly Gln Ser Thr Tyr Thr Val His Gln Gly Gln Ser Gly         
    825                 830                 835                         

ctg aag cat gga aac cgg ggc aag aga caa gca ctc aaa tct gcc tcc     2956
Leu Lys His Gly Asn Arg Gly Lys Arg Gln Ala Leu Lys Ser Ala Ser         
840                 845                 850                 855         

act gac ctg ggg aca gca gat gtt gtc ctg ggg cgg gtg ctg gag gtg     3004
Thr Asp Leu Gly Thr Ala Asp Val Val Leu Gly Arg Val Leu Glu Val         
                860                 865                 870             

aca gat ctc cct gag ggc atc acc cgt act gag gcg gac aaa ctc ttc     3052
Thr Asp Leu Pro Glu Gly Ile Thr Arg Thr Glu Ala Asp Lys Leu Phe         
            875                 880                 885                 

acg cag ctc gcc atg tct ggc gcc aag atc cag tgg ctc aag gat gct     3100
Thr Gln Leu Ala Met Ser Gly Ala Lys Ile Gln Trp Leu Lys Asp Ala         
        890                 895                 900                     

cag ggg ctg cct gga ggg ggt ggg ggg gac aac agt ggg act gct gag     3148
Gln Gly Leu Pro Gly Gly Gly Gly Gly Asp Asn Ser Gly Thr Ala Glu         
    905                 910                 915                         

aat ggc cgc cac tcg gac ctc gct gcc ttg tac acc att gtg gct gtg     3196
Asn Gly Arg His Ser Asp Leu Ala Ala Leu Tyr Thr Ile Val Ala Val         
920                 925                 930                 935         

ttc ccc agc ccc ctg gct gcc caa aat gcc tcc ctt cgt ctc aac aac     3244
Phe Pro Ser Pro Leu Ala Ala Gln Asn Ala Ser Leu Arg Leu Asn Asn         
                940                 945                 950             

tcc gtg agt cgc ttc aaa ctt cga atg gcc aaa aag aac tat gac ctg     3292
Ser Val Ser Arg Phe Lys Leu Arg Met Ala Lys Lys Asn Tyr Asp Leu         
            955                 960                 965                 

agg atc ctg gag cga gcc agc tcc caa taa atggaggagg ggaaagggac       3342
Arg Ile Leu Glu Arg Ala Ser Ser Gln                                     
        970                 975                                         

tgtcacagaa gaagcaaggg cagggtggag ggggttgaag gatcctgaca gaccatggac   3402

agaggcagga agtaaggaaa ctgatgttaa actggaacct aagacagtga tgaagatgga   3462

aacacagata cctacactgg cattggactc cttcttgctc ccctgccatg ggtcctctct   3522

ttttccctgg ttgacccccc ttgcatcact cttcttccca tcctcttctt tttttttttt   3582

tttttttttt tgagacggag tttcgctctt gtcaccccag ctggagtgca gtagcacgat   3642

cttggctaac tgcaacctcc agctcctggg ttcaggtgat tctcctgcct cagcctccca   3702

agtagctggc actacagaca cgcgccacca tgcccggcta atttttgtat ttttagtaga   3762

gacggagttt caccatgttg gccaggctgg cctcaaactc ctgacctcag gtgatccacc   3822

tgccttggcc ttccagagtg ctgggattac aggcgtgagc cactgtgcct ggcttccatc   3882

ctcttctatc atttttttaa atctcttctc ctatcataaa attaatttct cattttttgg   3942

tcaggtagaa ttgggaaagt cccacactgt cctcctatta ccttaacatc ccaagcttcc   4002

tttccttttt tggtctttat gaatatattt atatggacag aattaagata aacaaaattg   4062

attgccccat tctctcactt ccccatcttg tcttcctaga ccccacagag ttaaaacttg   4122

ggattcccct ggccccccca gaacacttgt atattgtttg tttgaggttc gtgccgcagt   4182

aacagacaca gtatttaatt gcacatacag atgtttgctg ggtatattca ctgtaaattt   4242

tatttaatct gtttttttgt ttgtttgggg gttatttggg gggaggttgg ttttgttttt   4302

aaatataaaa aaaaaaatct gtcactgg                                      4330


<210>  92
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ser Asn Ser Asn Thr Thr Gln Glu Thr Leu Glu Ile Met Lys Glu 
1               5                   10                  15      


Ser Glu Lys Lys Leu Val Glu Glu Ser Val Asn Lys Asn Lys Phe Ile 
            20                  25                  30          


Ser Lys Thr Pro Ser Lys Glu Glu Ile Glu Lys Glu Cys Glu Asp Thr 
        35                  40                  45              


Ser Leu Arg Gln Glu Thr Gln Arg Arg Thr Ser Asn His Gly His Ala 
    50                  55                  60                  


Arg Lys Arg Ala Lys Ser Asn Ser Lys Leu Lys Leu Val Arg Ser Leu 
65                  70                  75                  80  


Ala Val Cys Glu Glu Ser Ser Thr Pro Phe Ala Asp Gly Pro Leu Glu 
                85                  90                  95      


Thr Gln Asp Ile Ile Gln Leu His Ile Ser Cys Pro Ser Asp Lys Glu 
            100                 105                 110         


Glu Glu Lys Ser Thr Lys Asp Val Ser Glu Lys Glu Asp Lys Asp Lys 
        115                 120                 125             


Asn Lys Glu Lys Ile Pro Arg Lys Met Leu Ser Arg Asp Ser Ser Gln 
    130                 135                 140                 


Glu Tyr Thr Asp Ser Thr Gly Ile Asp Leu His Glu Phe Leu Val Asn 
145                 150                 155                 160 


Thr Leu Lys Lys Asn Pro Arg Asp Arg Met Met Leu Leu Lys Leu Glu 
                165                 170                 175     


Gln Glu Ile Leu Glu Phe Ile Asn Asp Asn Asn Asn Gln Phe Lys Lys 
            180                 185                 190         


Phe Pro Gln Met Thr Ser Tyr His Arg Met Leu Leu His Arg Val Ala 
        195                 200                 205             


Ala Tyr Phe Gly Met Asp His Asn Val Asp Gln Thr Gly Lys Ala Val 
    210                 215                 220                 


Ile Ile Asn Lys Thr Ser Asn Thr Arg Ile Pro Glu Gln Arg Phe Ser 
225                 230                 235                 240 


Glu His Ile Lys Asp Glu Lys Asn Thr Glu Phe Gln Gln Arg Phe Ile 
                245                 250                 255     


Leu Lys Arg Asp Asp Ala Ser Met Asp Arg Asp Asp Asn Gln Thr Gly 
            260                 265                 270         


Gln Asn Gly Tyr Leu Asn Asp Ile Arg Leu Ser Lys Glu Ala Phe Ser 
        275                 280                 285             


Ser Ser Ser His Lys Arg Arg Gln Ile Phe Arg Gly Asn Arg Glu Gly 
    290                 295                 300                 


Leu Ser Arg Thr Ser Ser Ser Arg Gln Ser Ser Thr Asp Ser Glu Leu 
305                 310                 315                 320 


Lys Ser Leu Glu Pro Arg Pro Trp Ser Ser Thr Asp Ser Asp Gly Ser 
                325                 330                 335     


Val Arg Ser Met Arg Pro Pro Val Thr Lys Ala Ser Ser Phe Ser Gly 
            340                 345                 350         


Ile Ser Ile Leu Thr Arg Gly Asp Ser Ile Gly Ser Ser Lys Gly Gly 
        355                 360                 365             


Ser Ala Gly Arg Ile Ser Arg Pro Gly Met Ala Leu Gly Ala Pro Glu 
    370                 375                 380                 


Val Cys Asn Gln Val Thr Ser Ser Gln Ser Val Arg Gly Leu Leu Pro 
385                 390                 395                 400 


Cys Thr Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu Pro Ala 
                405                 410                 415     


Leu Pro Pro Thr Pro Gln Gln Gln Pro Pro Leu Asn Asn His Met Ile 
            420                 425                 430         


Ser Gln Ala Asp Asp Leu Ser Asn Pro Phe Gly Gln Met Ser Leu Ser 
        435                 440                 445             


Arg Gln Gly Ser Thr Glu Ala Ala Asp Pro Ser Ala Ala Leu Phe Gln 
    450                 455                 460                 


Thr Pro Leu Ile Ser Gln His Pro Gln Gln Thr Ser Phe Ile Met Ala 
465                 470                 475                 480 


Ser Thr Gly Gln Pro Leu Pro Thr Ser Asn Tyr Ser Thr Ser Ser His 
                485                 490                 495     


Ala Pro Pro Thr Gln Gln Val Leu Pro Pro Gln Gly Tyr Met Gln Pro 
            500                 505                 510         


Pro Gln Gln Ile Gln Val Ser Tyr Tyr Pro Pro Gly Gln Tyr Pro Asn 
        515                 520                 525             


Ser Asn Gln Gln Tyr Arg Pro Leu Ser His Pro Val Ala Tyr Ser Pro 
    530                 535                 540                 


Gln Arg Gly Gln Gln Leu Pro Gln Pro Ser Gln Gln Pro Gly Leu Gln 
545                 550                 555                 560 


Pro Met Met Pro Asn Gln Gln Gln Ala Ala Tyr Gln Gly Met Ile Gly 
                565                 570                 575     


Val Gln Gln Pro Gln Asn Gln Gly Leu Leu Ser Ser Gln Arg Ser Ser 
            580                 585                 590         


Met Gly Gly Gln Met Gln Gly Leu Val Val Gln Tyr Thr Pro Leu Pro 
        595                 600                 605             


Ser Tyr Gln Val Pro Val Gly Ser Asp Ser Gln Asn Val Val Gln Pro 
    610                 615                 620                 


Pro Phe Gln Gln Pro Met Leu Val Pro Val Ser Gln Ser Val Gln Gly 
625                 630                 635                 640 


Gly Leu Pro Ala Ala Gly Val Pro Val Tyr Tyr Ser Met Ile Pro Pro 
                645                 650                 655     


Ala Gln Gln Asn Gly Thr Ser Pro Ser Val Gly Phe Leu Gln Pro Pro 
            660                 665                 670         


Gly Ser Glu Gln Tyr Gln Met Pro Gln Ser Pro Ser Pro Cys Ser Pro 
        675                 680                 685             


Pro Gln Met Pro Gln Gln Tyr Ser Gly Val Ser Pro Ser Gly Pro Gly 
    690                 695                 700                 


Val Val Val Met Gln Leu Asn Val Pro Asn Gly Pro Gln Pro Pro Gln 
705                 710                 715                 720 


Asn Pro Ser Met Val Gln Trp Ser His Cys Lys Tyr Tyr Ser Met Asp 
                725                 730                 735     


Gln Arg Gly Gln Lys Pro Gly Asp Leu Tyr Ser Pro Asp Ser Ser Pro 
            740                 745                 750         


Gln Ala Asn Thr Gln Met Ser Ser Ser Pro Val Thr Ser Pro Thr Gln 
        755                 760                 765             


Ser Pro Ala Pro Ser Pro Val Thr Ser Leu Ser Ser Val Cys Thr Gly 
    770                 775                 780                 


Leu Ser Pro Leu Pro Val Leu Thr Gln Phe Pro Arg Pro Gly Gly Pro 
785                 790                 795                 800 


Ala Gln Gly Asp Gly Arg Tyr Ser Leu Leu Gly Gln Pro Leu Gln Tyr 
                805                 810                 815     


Asn Leu Ser Ile Cys Pro Pro Leu Leu His Gly Gln Ser Thr Tyr Thr 
            820                 825                 830         


Val His Gln Gly Gln Ser Gly Leu Lys His Gly Asn Arg Gly Lys Arg 
        835                 840                 845             


Gln Ala Leu Lys Ser Ala Ser Thr Asp Leu Gly Thr Ala Asp Val Val 
    850                 855                 860                 


Leu Gly Arg Val Leu Glu Val Thr Asp Leu Pro Glu Gly Ile Thr Arg 
865                 870                 875                 880 


Thr Glu Ala Asp Lys Leu Phe Thr Gln Leu Ala Met Ser Gly Ala Lys 
                885                 890                 895     


Ile Gln Trp Leu Lys Asp Ala Gln Gly Leu Pro Gly Gly Gly Gly Gly 
            900                 905                 910         


Asp Asn Ser Gly Thr Ala Glu Asn Gly Arg His Ser Asp Leu Ala Ala 
        915                 920                 925             


Leu Tyr Thr Ile Val Ala Val Phe Pro Ser Pro Leu Ala Ala Gln Asn 
    930                 935                 940                 


Ala Ser Leu Arg Leu Asn Asn Ser Val Ser Arg Phe Lys Leu Arg Met 
945                 950                 955                 960 


Ala Lys Lys Asn Tyr Asp Leu Arg Ile Leu Glu Arg Ala Ser Ser Gln 
                965                 970                 975     


<210>  93
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Val Asp Lys Lys Leu Val Val Val Phe Gly Gly Thr Gly Ala Gln 
1               5                   10                  15      


Gly Gly Ser Val Ala Arg Thr Leu Leu Glu Asp Gly Thr Phe Lys Val 
            20                  25                  30          


Arg Val Val Thr Arg Asn Pro Arg Lys Lys Ala Ala Lys Glu Leu Arg 
        35                  40                  45              


Leu Gln Gly Ala Glu Val Val Gln Gly Asp Gln Asp Asp Gln Val Ile 
    50                  55                  60                  


Met Glu Leu Ala Leu Asn Gly Ala Tyr Ala Thr Phe Ile Val Thr Asn 
65                  70                  75                  80  


Tyr Trp Glu Ser Cys Ser Gln Glu Gln Glu Val Lys Gln Gly Lys Leu 
                85                  90                  95      


Leu Ala Asp Leu Ala Arg Arg Leu Gly Leu His Tyr Val Val Tyr Ser 
            100                 105                 110         


Gly Leu Glu Asn Ile Lys Lys Leu Thr Ala Gly Arg Leu Ala Ala Ala 
        115                 120                 125             


His Phe Asp Gly Lys Gly Glu Val Glu Glu Tyr Phe Arg Asp Ile Gly 
    130                 135                 140                 


Val Pro Met Thr Ser Val Arg Leu Pro Cys Tyr Phe Glu Asn Leu Leu 
145                 150                 155                 160 


Ser His Phe Leu Pro Gln Lys Ala Pro Asp Gly Lys Ser Tyr Leu Leu 
                165                 170                 175     


Ser Leu Pro Thr Gly Asp Val Pro Met Asp Gly Met Ser Val Ser Asp 
            180                 185                 190         


Leu Gly Pro Val Val Leu Ser Leu Leu Lys Met Pro Glu Lys Tyr Val 
        195                 200                 205             


Gly Gln Asn Ile Gly Leu Ser Thr Cys Arg His Thr Ala Glu Glu Tyr 
    210                 215                 220                 


Ala Ala Leu Leu Thr Lys His Thr Arg Lys Val Val His Asp Ala Lys 
225                 230                 235                 240 


Met Thr Pro Glu Asp Tyr Glu Lys Leu Gly Phe Pro Gly Ala Arg Asp 
                245                 250                 255     


Leu Ala Asn Met Phe Arg Phe Tyr Ala Leu Arg Pro Asp Arg Asp Ile 
            260                 265                 270         


Glu Leu Thr Leu Arg Leu Asn Pro Lys Ala Leu Thr Leu Asp Gln Trp 
        275                 280                 285             


Leu Glu Gln His Lys Gly Asp Phe Asn Leu Leu 
    290                 295                 


<210>  94
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Val Ala Leu Val Ser Val Phe Thr Met Cys Val Gln Ser Ile Met 
1               5                   10                  15      


Lys Lys Ser Ile Phe Asn Val Cys Gly Leu Leu Gln Gly Ile Ala Gly 
            20                  25                  30          


Leu Phe Leu Ile Leu Gly Leu Ile Leu Tyr Pro Ala Gly Trp Gly Cys 
        35                  40                  45              


Gln Lys Ala Ile Asp Tyr Cys Gly His Tyr Ala Ser Ala Tyr Lys Pro 
    50                  55                  60                  


Gly Asp Cys Ser Leu Gly Trp Ala Phe Tyr Thr Ala Ile Gly Gly Thr 
65                  70                  75                  80  


Val Leu Thr Phe Ile Cys Ala Val Phe Ser Ala Gln Ala Glu Ile Ala 
                85                  90                  95      


Thr Ser Ser Asp Lys Val Gln Glu Glu Ile Glu Glu Gly Lys Asn Leu 
            100                 105                 110         


Ile Cys Leu Leu 
        115     


<210>  95
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Arg Ala Ser Leu Ile Leu Ile Arg Glu Ile Leu Trp Glu Met Ile 
1               5                   10                  15      


Leu Lys Val Leu Ile Glu Gly Leu Gln Leu Pro Ile His Val Phe Arg 
            20                  25                  30          


Glu Pro Leu Arg Phe His Lys Arg Ser Leu Gln Ser Phe Val Leu Val 
        35                  40                  45              


Gln Asn Pro Ser Gly Lys Phe Gln Phe Leu Arg Pro Leu Arg Lys Leu 
    50                  55                  60                  


Ile Gln Met Pro Lys Lys Asp Arg Ile Glu Val Gln Ile Thr 
65                  70                  75              


<210>  96
<211>  828
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Arg Asn Gly Lys Thr Glu Cys Tyr Leu Ser Ile Gln Thr Gln Glu 
1               5                   10                  15      


Asn Phe Pro Ala Asn Leu Asn Glu Leu Val Asn Cys Ile Val Ile Ser 
            20                  25                  30          


Ser Leu Val Thr Thr Gln Arg Lys Leu Lys Ala Met Ser Leu Leu Gly 
        35                  40                  45              


Ser Arg Asn Gln Leu Ala Arg Ala Val Leu Asn Pro Asn Pro Met Asp 
    50                  55                  60                  


Phe Cys Thr Lys Asp Leu Leu Thr Thr Thr Ser Glu Arg Ile Ile Ala 
65                  70                  75                  80  


Tyr Leu Arg Asp Phe Asn Glu Asp Gln Lys Lys Ala Ile Glu Thr Ala 
                85                  90                  95      


Tyr Ala Met Val Lys His Ser Pro Ser Val Ala Lys Ile Cys Leu Ile 
            100                 105                 110         


His Gly Pro Pro Gly Thr Gly Lys Ser Lys Thr Ile Val Gly Leu Leu 
        115                 120                 125             


Tyr Arg Leu Leu Thr Glu Asn Gln Arg Lys Gly His Ser Asp Glu Asn 
    130                 135                 140                 


Ser Asn Ala Lys Ile Lys Gln Asn Arg Val Leu Val Cys Ala Pro Ser 
145                 150                 155                 160 


Asn Ala Ala Val Asp Glu Leu Met Lys Lys Ile Ile Leu Glu Phe Lys 
                165                 170                 175     


Glu Lys Cys Lys Asp Lys Lys Asn Pro Leu Gly Asn Cys Gly Asp Ile 
            180                 185                 190         


Asn Leu Val Arg Leu Gly Pro Glu Lys Ser Ile Asn Ser Glu Val Leu 
        195                 200                 205             


Lys Phe Ser Leu Asp Ser Gln Val Asn His Arg Met Lys Lys Glu Leu 
    210                 215                 220                 


Pro Ser His Val Gln Ala Met His Lys Arg Lys Glu Phe Leu Asp Tyr 
225                 230                 235                 240 


Gln Leu Asp Glu Leu Ser Arg Gln Arg Ala Leu Cys Arg Gly Gly Arg 
                245                 250                 255     


Glu Ile Gln Arg Gln Glu Leu Asp Glu Asn Ile Ser Lys Val Ser Lys 
            260                 265                 270         


Glu Arg Gln Glu Leu Ala Ser Lys Ile Lys Glu Val Gln Gly Arg Pro 
        275                 280                 285             


Gln Lys Thr Gln Ser Ile Ile Ile Leu Glu Ser His Ile Ile Cys Cys 
    290                 295                 300                 


Thr Leu Ser Thr Ser Gly Gly Leu Leu Leu Glu Ser Ala Phe Arg Gly 
305                 310                 315                 320 


Gln Gly Gly Val Pro Phe Ser Cys Val Ile Val Asp Glu Ala Gly Gln 
                325                 330                 335     


Ser Cys Glu Ile Glu Thr Leu Thr Pro Leu Ile His Arg Cys Asn Lys 
            340                 345                 350         


Leu Ile Leu Val Gly Asp Pro Lys Gln Leu Pro Pro Thr Val Ile Ser 
        355                 360                 365             


Met Lys Ala Gln Glu Tyr Gly Tyr Asp Gln Ser Met Met Ala Arg Phe 
    370                 375                 380                 


Cys Arg Leu Leu Glu Glu Asn Val Glu His Asn Met Ile Ser Arg Leu 
385                 390                 395                 400 


Pro Ile Leu Gln Leu Thr Val Gln Tyr Arg Met His Pro Asp Ile Cys 
                405                 410                 415     


Leu Phe Pro Ser Asn Tyr Val Tyr Asn Arg Asn Leu Lys Thr Asn Arg 
            420                 425                 430         


Gln Thr Glu Ala Ile Arg Cys Ser Ser Asp Trp Pro Phe Gln Pro Tyr 
        435                 440                 445             


Leu Val Phe Asp Val Gly Asp Gly Ser Glu Arg Arg Asp Asn Asp Ser 
    450                 455                 460                 


Tyr Ile Asn Val Gln Glu Ile Lys Leu Val Met Glu Ile Ile Lys Leu 
465                 470                 475                 480 


Ile Lys Asp Lys Arg Lys Asp Val Ser Phe Arg Asn Ile Gly Ile Ile 
                485                 490                 495     


Thr His Tyr Lys Ala Gln Lys Thr Met Ile Gln Lys Asp Leu Asp Lys 
            500                 505                 510         


Glu Phe Asp Arg Lys Gly Pro Ala Glu Val Asp Thr Val Asp Ala Phe 
        515                 520                 525             


Gln Gly Arg Gln Lys Asp Cys Val Ile Val Thr Cys Val Arg Ala Asn 
    530                 535                 540                 


Ser Ile Gln Gly Ser Ile Gly Phe Leu Ala Ser Leu Gln Arg Leu Asn 
545                 550                 555                 560 


Val Thr Ile Thr Arg Ala Lys Tyr Ser Leu Phe Ile Leu Gly His Leu 
                565                 570                 575     


Arg Thr Leu Met Glu Asn Gln His Trp Asn Gln Leu Ile Gln Asp Ala 
            580                 585                 590         


Gln Lys Arg Gly Ala Ile Ile Lys Thr Cys Asp Lys Asn Tyr Arg His 
        595                 600                 605             


Asp Ala Val Lys Ile Leu Lys Leu Lys Pro Val Leu Gln Arg Ser Leu 
    610                 615                 620                 


Thr His Pro Pro Thr Ile Ala Pro Glu Gly Ser Arg Pro Gln Gly Gly 
625                 630                 635                 640 


Leu Pro Ser Ser Lys Leu Asp Ser Gly Phe Ala Lys Thr Ser Val Ala 
                645                 650                 655     


Ala Ser Leu Tyr His Thr Pro Ser Asp Ser Lys Glu Ile Thr Leu Thr 
            660                 665                 670         


Val Thr Ser Lys Asp Pro Glu Arg Pro Pro Val His Asp Gln Leu Gln 
        675                 680                 685             


Asp Pro Arg Leu Leu Lys Arg Met Gly Ile Glu Val Lys Gly Gly Ile 
    690                 695                 700                 


Phe Leu Trp Asp Pro Gln Pro Ser Ser Pro Gln His Pro Gly Ala Thr 
705                 710                 715                 720 


Pro Pro Thr Gly Glu Pro Gly Phe Pro Val Val His Gln Asp Leu Ser 
                725                 730                 735     


His Ile Gln Gln Pro Ala Ala Val Val Ala Ala Leu Ser Ser His Lys 
            740                 745                 750         


Pro Pro Val Arg Gly Glu Pro Pro Ala Ala Ser Pro Glu Ala Ser Thr 
        755                 760                 765             


Cys Gln Ser Lys Cys Asp Asp Pro Glu Glu Glu Leu Cys His Arg Arg 
    770                 775                 780                 


Glu Ala Arg Ala Phe Ser Glu Gly Glu Gln Glu Lys Cys Gly Ser Glu 
785                 790                 795                 800 


Thr His His Thr Arg Arg Asn Ser Arg Trp Asp Lys Arg Thr Leu Glu 
                805                 810                 815     


Gln Glu Asp Ser Ser Ser Lys Lys Arg Lys Leu Leu 
            820                 825             


<210>  97
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Leu Cys Lys Gln Thr Trp Pro His Trp Lys Gly Pro Ala Arg Ser 
1               5                   10                  15      


Gly Val Glu Val Leu Phe Asn Glu Leu Glu Ile Pro Val Glu Glu Tyr 
            20                  25                  30          


Ser Phe Gly Arg Ser Lys Ile Phe Ile Arg Asn Pro Arg Thr Leu Phe 
        35                  40                  45              


Lys Leu Glu Asp Leu Arg Lys Gln Arg Leu Glu Asp Leu Ala Thr Leu 
    50                  55                  60                  


Ile Gln Lys Ile Tyr Arg Gly Trp Lys Cys Arg Thr His Phe Leu Leu 
65                  70                  75                  80  


Met Lys Lys Ser Gln Ile Val Ile Ala Ala Trp Tyr Arg Arg Tyr Ala 
                85                  90                  95      


Gln Gln Lys Arg Tyr Gln Gln Thr Lys Ser Ser Ala Leu Val Ile Gln 
            100                 105                 110         


Ser Tyr Ile Arg Gly Trp Lys Ala Arg Lys Ile Leu Arg Glu Leu Lys 
        115                 120                 125             


His Gln Lys Arg Cys Lys Glu Ala Val Thr Thr Ile Ala Ala Tyr Trp 
    130                 135                 140                 


His Gly Thr Gln Val Arg Arg Glu Tyr Arg Lys Phe Phe Arg Ala Asn 
145                 150                 155                 160 


Ala Gly Lys Lys Ile Tyr Glu Phe Thr Leu Gln Arg Ile Val Gln Lys 
                165                 170                 175     


Tyr Phe Leu Glu Met Lys Asn Lys Met Pro Ser Leu Ser Pro Ile Asp 
            180                 185                 190         


Lys Asn Trp Pro Ser Arg Pro Tyr Leu Phe Leu Asp Ser Thr His Lys 
        195                 200                 205             


Glu Leu Lys Arg Ile Phe His Leu Trp Arg Val Lys Asn Thr Gly Thr 
    210                 215                 220                 


Asn Ser Gln Thr Ser Arg Asn Leu Phe Met Lys Arg Asn 
225                 230                 235         


<210>  98
<211>  811
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Asn Lys Val Glu Gln Lys Ser Gln Glu Ser Val Ser Phe Lys Asp 
1               5                   10                  15      


Val Thr Val Gly Phe Thr Gln Glu Glu Trp Gln His Leu Asp Pro Ser 
            20                  25                  30          


Gln Arg Ala Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser Asn Leu 
        35                  40                  45              


Val Ser Val Gly Tyr Cys Val His Lys Pro Glu Val Ile Phe Arg Leu 
    50                  55                  60                  


Gln Gln Gly Glu Glu Pro Trp Lys Gln Glu Glu Glu Phe Pro Ser Gln 
65                  70                  75                  80  


Ser Phe Pro Glu Val Trp Thr Ala Asp His Leu Lys Glu Arg Ser Gln 
                85                  90                  95      


Glu Asn Gln Ser Lys His Leu Trp Glu Val Val Phe Ile Asn Asn Glu 
            100                 105                 110         


Met Leu Thr Lys Glu Gln Gly Asp Val Ile Gly Ile Pro Phe Asn Val 
        115                 120                 125             


Asp Val Ser Ser Phe Pro Ser Arg Lys Met Phe Cys Gln Cys Asp Ser 
    130                 135                 140                 


Cys Gly Met Ser Phe Asn Thr Val Ser Glu Leu Val Ile Ser Lys Ile 
145                 150                 155                 160 


Asn Tyr Leu Gly Lys Lys Ser Asp Glu Phe Asn Ala Cys Gly Lys Leu 
                165                 170                 175     


Leu Leu Asn Ile Lys His Asp Glu Thr His Thr Gln Glu Lys Asn Glu 
            180                 185                 190         


Val Leu Lys Asn Arg Asn Thr Leu Ser His His Glu Glu Thr Leu Gln 
        195                 200                 205             


His Glu Lys Ile Gln Thr Leu Glu His Asn Phe Glu Tyr Ser Ile Cys 
    210                 215                 220                 


Gln Glu Thr Leu Leu Glu Lys Ala Val Phe Asn Thr Gln Lys Arg Glu 
225                 230                 235                 240 


Asn Ala Glu Glu Asn Asn Cys Asp Tyr Asn Glu Phe Gly Arg Thr Leu 
                245                 250                 255     


Cys Asp Ser Ser Ser Leu Leu Phe His Gln Ile Ser Pro Ser Arg Asp 
            260                 265                 270         


Asn His Tyr Glu Phe Ser Asp Cys Glu Lys Phe Leu Cys Val Lys Ser 
        275                 280                 285             


Thr Leu Ser Lys Pro His Gly Val Ser Met Lys His Tyr Asp Cys Gly 
    290                 295                 300                 


Glu Ser Gly Asn Asn Phe Arg Arg Lys Leu Cys Leu Ser His Leu Gln 
305                 310                 315                 320 


Lys Gly Asp Lys Gly Glu Lys His Phe Glu Cys Asn Glu Cys Gly Lys 
                325                 330                 335     


Ala Phe Trp Glu Lys Ser His Leu Thr Arg His Gln Arg Val His Thr 
            340                 345                 350         


Gly Gln Lys Pro Phe Gln Cys Asn Glu Cys Glu Lys Ala Phe Trp Asp 
        355                 360                 365             


Lys Ser Asn Leu Thr Lys His Gln Arg Ser His Thr Gly Glu Lys Pro 
    370                 375                 380                 


Phe Glu Cys Asn Glu Cys Gly Lys Ala Phe Ser His Lys Ser Ala Leu 
385                 390                 395                 400 


Thr Leu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Gln Cys Asn 
                405                 410                 415     


Ala Cys Gly Lys Thr Phe Cys Gln Lys Ser Asp Leu Thr Lys His Gln 
            420                 425                 430         


Arg Thr His Thr Gly Leu Lys Pro Tyr Glu Cys Tyr Glu Cys Gly Lys 
        435                 440                 445             


Ser Phe Arg Val Thr Ser His Leu Lys Val His Gln Arg Thr His Thr 
    450                 455                 460                 


Gly Glu Lys Pro Phe Glu Cys Leu Glu Cys Gly Lys Ser Phe Ser Glu 
465                 470                 475                 480 


Lys Ser Asn Leu Thr Gln His Gln Arg Ile His Ile Gly Asp Lys Ser 
                485                 490                 495     


Tyr Glu Cys Asn Ala Cys Gly Lys Thr Phe Tyr His Lys Ser Leu Leu 
            500                 505                 510         


Thr Arg His Gln Ile Ile His Thr Gly Trp Lys Pro Tyr Glu Cys Tyr 
        515                 520                 525             


Glu Cys Gly Lys Thr Phe Cys Leu Lys Ser Asp Leu Thr Val His Gln 
    530                 535                 540                 


Arg Thr His Thr Gly Gln Lys Pro Phe Ala Cys Pro Glu Cys Gly Lys 
545                 550                 555                 560 


Phe Phe Ser His Lys Ser Thr Leu Ser Gln His Tyr Arg Thr His Thr 
                565                 570                 575     


Gly Glu Lys Pro Tyr Glu Cys His Glu Cys Gly Lys Ile Phe Tyr Asn 
            580                 585                 590         


Lys Ser Tyr Leu Thr Lys His Asn Arg Thr His Thr Gly Glu Lys Pro 
        595                 600                 605             


Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Tyr Gln Lys Ser Gln Leu 
    610                 615                 620                 


Thr Gln His Gln Arg Ile His Ile Gly Glu Lys Pro Tyr Lys Cys Asn 
625                 630                 635                 640 


Glu Cys Gly Lys Ala Phe Cys His Lys Ser Ala Leu Ile Val His Gln 
                645                 650                 655     


Arg Thr His Thr Gln Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys 
            660                 665                 670         


Ser Phe Cys Val Lys Ser Gly Leu Ile Phe His Glu Arg Lys His Thr 
        675                 680                 685             


Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Phe Phe Arg His 
    690                 695                 700                 


Lys Ser Ser Leu Thr Val His His Arg Ala His Thr Gly Glu Lys Ser 
705                 710                 715                 720 


Cys Gln Cys Asn Glu Cys Gly Lys Ile Phe Tyr Arg Lys Ser Glu Leu 
                725                 730                 735     


Ala Gln His Gln Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Asn 
            740                 745                 750         


Thr Cys Arg Lys Thr Phe Ser Gln Lys Ser Asn Leu Ile Val His Gln 
        755                 760                 765             


Arg Arg His Ile Gly Glu Asn Leu Met Asn Glu Met Asp Ile Arg Asn 
    770                 775                 780                 


Phe Gln Pro Gln Val Ser Leu His Asn Ala Ser Glu Tyr Ser His Cys 
785                 790                 795                 800 


Gly Glu Ser Pro Asp Asp Ile Leu Asn Val Gln 
                805                 810     


<210>  99
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Ala Ile Pro Gly Arg Gln Tyr Gly Leu Ile Leu Pro Lys Lys Thr 
1               5                   10                  15      


Gln Gln Leu His Pro Val Leu Gln Lys Pro Ser Val Phe Gly Asn Asp 
            20                  25                  30          


Ser Asp Asp Asp Asp Glu Thr Ser Val Ser Glu Ser Leu Gln Arg Glu 
        35                  40                  45              


Ala Ala Lys Lys Gln Ala Met Lys Gln Thr Lys Leu Glu Ile Gln Lys 
    50                  55                  60                  


Ala Leu Ala Glu Asp Ala Thr Val Tyr Glu Tyr Asp Ser Ile Tyr Asp 
65                  70                  75                  80  


Glu Met Gln Lys Lys Lys Glu Glu Asn Asn Pro Lys Leu Leu Leu Gly 
                85                  90                  95      


Lys Asp Arg Lys Pro Lys Tyr Ile His Asn Leu Leu Lys Ala Val Glu 
            100                 105                 110         


Ile Arg Lys Lys Glu Gln Glu Lys Arg Met Glu Lys Lys Ile Gln Arg 
        115                 120                 125             


Glu Arg Glu Met Glu Lys Gly Glu Phe Asp Asp Lys Glu Ala Phe Val 
    130                 135                 140                 


Thr Ser Ala Tyr Lys Lys Lys Leu Gln Glu Arg Ala Glu Glu Glu Glu 
145                 150                 155                 160 


Arg Glu Lys Arg Ala Ala Ala Leu Glu Ala Cys Leu Asp Val Thr Lys 
                165                 170                 175     


Gln Lys Asp Leu Ser Gly Phe Tyr Arg His Leu Leu Asn Gln Ala Val 
            180                 185                 190         


Gly Glu Glu Glu Val Pro Lys Cys Ser Phe Arg Glu Ala Arg Ser Gly 
        195                 200                 205             


Ile Lys Glu Glu Lys Ser Arg Gly Phe Ser Asn Glu Val Ser Ser Lys 
    210                 215                 220                 


Asn Arg Ile Pro Gln Glu Lys Cys Ile Leu Gln Thr Asp Val Lys Val 
225                 230                 235                 240 


Glu Glu Asn Pro Asp Ala Asp Ser Asp Phe Asp Ala Lys Ser Ser Ala 
                245                 250                 255     


Asp Asp Glu Ile Glu Glu Thr Arg Val Asn Cys Arg Arg Glu Lys Val 
            260                 265                 270         


Ile Glu Thr Pro Glu Asn Asp Phe Lys His His Arg Ser Gln Asn His 
        275                 280                 285             


Ser Arg Ser Pro Ser Glu Glu Arg Gly His Ser Thr Arg His His Thr 
    290                 295                 300                 


Lys Gly Ser Arg Thr Ser Arg Gly His Glu Lys Arg Glu Asp Gln His 
305                 310                 315                 320 


Gln Gln Lys Gln Ser Arg Asp Gln Glu Asn His Tyr Thr Asp Arg Asp 
                325                 330                 335     


Tyr Arg Lys Glu Arg Asp Ser His Arg His Arg Glu Ala Ser His Arg 
            340                 345                 350         


Asp Ser His Trp Lys Arg His Glu Gln Glu Asp Lys Pro Arg Ala Arg 
        355                 360                 365             


Asp Gln Arg Glu Arg Ser Asp Arg Val Trp Lys Arg Glu Lys Asp Arg 
    370                 375                 380                 


Glu Lys Tyr Ser Gln Arg Glu Gln Glu Arg Asp Arg Gln Gln Asn Asp 
385                 390                 395                 400 


Gln Asn Arg Pro Ser Glu Lys Gly Glu Lys Glu Glu Lys Ser Lys Ala 
                405                 410                 415     


Lys Glu Glu His Met Lys Val Arg Lys Glu Arg Tyr Glu Asn Asn Asp 
            420                 425                 430         


Lys Tyr Arg Asp Arg Glu Lys Arg Glu Val Gly Val Gln Ser Ser Glu 
        435                 440                 445             


Arg Asn Gln Asp Arg Lys Glu Ser Ser Pro Asn Ser Arg Ala Lys Asp 
    450                 455                 460                 


Lys Phe Leu Asp Gln Glu Arg Ser Asn Lys Met Arg Asn Met Ala Lys 
465                 470                 475                 480 


Asp Lys Glu Arg Asn Gln Glu Lys Pro Ser Asn Ser Glu Ser Ser Leu 
                485                 490                 495     


Gly Ala Lys His Arg Leu Thr Glu Glu Gly Gln Glu Lys Gly Lys Glu 
            500                 505                 510         


Gln Glu Arg Pro Pro Glu Ala Val Ser Lys Phe Ala Lys Arg Asn Asn 
        515                 520                 525             


Glu Glu Thr Val Met Ser Ala Arg Asp Arg Tyr Leu Ala Arg Gln Met 
    530                 535                 540                 


Ala Arg Val Asn Ala Lys Thr Tyr Ile Glu Lys Glu Asp Asp 
545                 550                 555             


<210>  100
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Leu Leu Leu Arg Cys Gln Leu Lys Gln Ala Pro Pro Gln Lys Val 
1               5                   10                  15      


Ser Phe Arg Phe Cys Val Val Met Gly Lys Gln Gln Ser Lys Leu Lys 
            20                  25                  30          


His Ser Thr Tyr Lys Tyr Gly Pro Asp Glu Ile Ile Glu Glu Arg Ile 
        35                  40                  45              


Gln Thr Lys Ala Phe Gln Glu Tyr Ser Pro Ala His Met Asp Thr Val 
    50                  55                  60                  


Ser Val Val Ala Ala Leu Asn Ser Asp Leu Cys Val Ser Gly Gly Lys 
65                  70                  75                  80  


Asp Lys Thr Val Val Ala Tyr Asn Trp Lys Thr Gly Asn Val Val Lys 
                85                  90                  95      


Arg Phe Lys Gly His Glu His Glu Ile Thr Lys Val Ala Cys Ile Pro 
            100                 105                 110         


Lys Ser Ser Gln Phe Phe Ser Ala Ser Arg Asp Arg Met Val Met Met 
        115                 120                 125             


Trp Asp Leu His Gly Ser Ser Gln Pro Arg Gln Gln Leu Cys Gly His 
    130                 135                 140                 


Ala Met Val Val Thr Gly Leu Ala Val Ser Pro Asp Ser Ser Gln Leu 
145                 150                 155                 160 


Cys Thr Gly Ser Arg Asp Asn Thr Leu Leu Leu Trp Asp Val Val Thr 
                165                 170                 175     


Gly Gln Ser Val Glu Arg Ala Ser Val Ser Arg Asn Val Val Thr His 
            180                 185                 190         


Leu Cys Trp Val Pro Arg Glu Pro Tyr Ile Leu Gln Thr Ser Glu Asp 
        195                 200                 205             


Lys Thr Leu Arg Leu Trp Asp Ser Arg Gly Leu Gln Val Ala His Met 
    210                 215                 220                 


Phe Pro Ala Lys Gln His Ile Gln Thr Tyr Cys Glu Val Ser Val Asp 
225                 230                 235                 240 


Gly His Lys Cys Ile Ser Cys Ser Asn Gly Phe Gly Gly Glu Gly Cys 
                245                 250                 255     


Glu Ala Thr Leu Trp Asp Leu Arg Gln Thr Arg Asn Arg Ile Cys Glu 
            260                 265                 270         


Tyr Lys Gly His Phe Gln Thr Val Ala Ser Cys Val Phe Leu Pro Arg 
        275                 280                 285             


Ala Leu Ala Leu Met Pro Leu Ile Ala Thr Ser Ser His Asp Cys Lys 
    290                 295                 300                 


Val Lys Ile Trp Asn Gln Asp Thr Gly Ala Cys Leu Phe Thr Leu Ser 
305                 310                 315                 320 


Leu Asp Gly Ser Gly Pro Leu Thr Ser Leu Ala Val Gly Asp Ala Ile 
                325                 330                 335     


Ser Leu Leu Cys Ala Ser Phe Asn Arg Gly Ile His Leu Leu Arg Met 
            340                 345                 350         


Asp His Ser Gln Gly Leu Glu Leu Gln Glu Val Ala Ala Phe 
        355                 360                 365     


<210>  101
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Phe Gly Lys Leu Met Thr Ile Ala Lys Asn Leu Pro Asp Pro Gly 
1               5                   10                  15      


Lys Ala Gln Asp Phe Val Lys Lys Phe Asn Gln Val Leu Gly Asp Asp 
            20                  25                  30          


Glu Lys Leu Arg Ser Gln Leu Glu Leu Leu Ile Ser Pro Thr Cys Ser 
        35                  40                  45              


Cys Lys Gln Ala Asp Ile Cys Val Arg Glu Ile Ala Arg Lys Leu Ala 
    50                  55                  60                  


Asn Pro Lys Gln Pro Thr Asn Pro Phe Leu Glu Met Val Lys Phe Leu 
65                  70                  75                  80  


Leu Glu Arg Ile Ala Pro Val His Ile Asp Ser Glu Ala Ile Ser Ala 
                85                  90                  95      


Leu Val Lys Leu Met Asn Lys Ser Ile Glu Gly Thr Ala Asp Asp Glu 
            100                 105                 110         


Glu Glu Gly Val Ser Pro Asp Thr Ala Ile Arg Ser Gly Leu Glu Leu 
        115                 120                 125             


Leu Lys Val Leu Ser Phe Thr His Pro Thr Ser Phe His Ser Ala Glu 
    130                 135                 140                 


Thr Tyr Glu Ser Leu Leu Gln Cys Leu Arg Met Glu Asp Asp Lys Val 
145                 150                 155                 160 


Ala Glu Ala Ala Ile Gln Ile Phe Arg Asn Thr Gly His Lys Ile Glu 
                165                 170                 175     


Thr Asp Leu Pro Gln Ile Arg Ser Thr Leu Ile Pro Ile Leu His Gln 
            180                 185                 190         


Lys Ala Lys Arg Gly Thr Pro His Gln Ala Lys Gln Ala Val His Cys 
        195                 200                 205             


Ile His Ala Ile Phe Thr Asn Lys Glu Val Gln Leu Ala Gln Ile Phe 
    210                 215                 220                 


Glu Pro Leu Ser Arg Ser Leu Asn Ala Asp Val Pro Glu Gln Leu Ile 
225                 230                 235                 240 


Thr Pro Leu Val Ser Leu Gly His Ile Ser Met Leu Ala Pro Asp Gln 
                245                 250                 255     


Phe Ala Ser Pro Met Lys Ser Val Val Ala Asn Phe Ile Val Lys Asp 
            260                 265                 270         


Leu Leu Met Asn Asp Arg Ser Thr Gly Glu Lys Asn Gly Lys Leu Trp 
        275                 280                 285             


Ser Pro Asp Glu Glu Val Ser Pro Glu Val Leu Ala Lys Val Gln Ala 
    290                 295                 300                 


Ile Lys Leu Leu Val Arg Trp Leu Leu Gly Met Lys Asn Asn Gln Ser 
305                 310                 315                 320 


Lys Ser Ala Asn Ser Thr Leu Arg Leu Leu Ser Ala Met Leu Val Ser 
                325                 330                 335     


Glu Gly Asp Leu Thr Glu Gln Lys Arg Ile Ser Lys Ser Asp Met Ser 
            340                 345                 350         


Arg Leu Arg Leu Ala Ala Gly Ser Ala Ile Met Lys Leu Ala Gln Glu 
        355                 360                 365             


Pro Cys Tyr His Glu Ile Ile Thr Pro Glu Gln Phe Gln Leu Cys Ala 
    370                 375                 380                 


Leu Val Ile Asn Asp Glu Cys Tyr Gln Val Arg Gln Ile Phe Ala Gln 
385                 390                 395                 400 


Lys Leu His Lys Ala Leu Val Lys Leu Leu Leu Pro Leu Glu Tyr Met 
                405                 410                 415     


Ala Ile Phe Ala Leu Cys Ala Lys Asp Pro Val Lys Glu Arg Arg Ala 
            420                 425                 430         


His Ala Arg Gln Cys Leu Leu Lys Asn Ile Ser Ile Arg Arg Glu Tyr 
        435                 440                 445             


Ile Lys Gln Asn Pro Met Ala Thr Glu Lys Leu Leu Ser Leu Leu Pro 
    450                 455                 460                 


Glu Tyr Val Val Pro Tyr Met Ile His Leu Leu Ala His Asp Pro Asp 
465                 470                 475                 480 


Phe Thr Arg Ser Gln Asp Val Asp Gln Leu Arg Asp Ile Lys Glu Cys 
                485                 490                 495     


Leu Trp Phe Met Leu Glu Val Leu Met Thr Lys Asn Glu Asn Asn Ser 
            500                 505                 510         


His Ala Phe Met Lys Lys Met Ala Glu Asn Ile Lys Leu Thr Arg Asp 
        515                 520                 525             


Ala Gln Ser Pro Asp Glu Ser Lys Thr Asn Glu Lys Leu Tyr Thr Val 
    530                 535                 540                 


Cys Asp Val Ala Leu Cys Val Ile Asn Ser Lys Ser Ala Leu Cys Asn 
545                 550                 555                 560 


Ala Asp Ser Pro Lys Asp Pro Val Leu Pro Met Lys Phe Phe Thr Gln 
                565                 570                 575     


Pro Glu Lys Asp Phe Cys Asn Asp Lys Ser Tyr Ile Ser Glu Glu Thr 
            580                 585                 590         


Arg Val Leu Leu Leu Thr Gly Lys Pro Lys Pro Ala Gly Val Leu Gly 
        595                 600                 605             


Ala Val Asn Lys Pro Leu Ser Ala Thr Gly Arg Lys Pro Tyr Val Arg 
    610                 615                 620                 


Ser Thr Gly Thr Glu Thr Gly Ser Asn Ile Asn Val Asn Ser Glu Leu 
625                 630                 635                 640 


Asn Pro Ser Thr Gly Asn Arg Ser Arg Glu Gln Ser Ser Glu Ala Ala 
                645                 650                 655     


Glu Thr Gly Val Ser Glu Asn Glu Glu Asn Pro Val Arg Ile Ile Ser 
            660                 665                 670         


Val Thr Pro Val Lys Asn Ile Asp Pro Val Lys Asn Lys Gly Asn 
        675                 680                 685         


<210>  102
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Ala Ala Ala Ala Ser His Leu Asn Leu Asp Ala Leu Arg Glu 
1               5                   10                  15      


Val Leu Glu Cys Pro Ile Cys Met Glu Ser Ile Thr Glu Glu Gln Leu 
            20                  25                  30          


Arg Pro Lys Leu Leu His Cys Gly His Thr Ile Cys Arg Gln Cys Leu 
        35                  40                  45              


Glu Lys Leu Leu Ala Ser Ser Ile Asn Gly Val Arg Cys Pro Phe Cys 
    50                  55                  60                  


Ser Lys Ile Thr Arg Ile Thr Ser Leu Thr Gln Leu Thr Asp Asn Leu 
65                  70                  75                  80  


Thr Val Leu Lys Ile Ile Asp Thr Ala Gly Leu Ser Glu Ala Val Gly 
                85                  90                  95      


Leu Leu Met Cys Arg Ser Cys Gly Arg Arg Leu Pro Arg Gln Phe Cys 
            100                 105                 110         


Arg Ser Cys Gly Leu Val Leu Cys Glu Pro Cys Arg Glu Ala Asp His 
        115                 120                 125             


Gln Pro Pro Gly His Cys Thr Leu Pro Val Lys Glu Ala Ala Glu Glu 
    130                 135                 140                 


Arg Arg Arg Asp Phe Gly Glu Lys Leu Thr Arg Leu Arg Glu Leu Met 
145                 150                 155                 160 


Gly Glu Leu Gln Arg Arg Lys Ala Ala Leu Glu Gly Val Ser Lys Asp 
                165                 170                 175     


Leu Gln Ala Arg Tyr Lys Ala Val Leu Gln Glu Tyr Gly His Glu Glu 
            180                 185                 190         


Arg Arg Val Gln Asp Glu Leu Ala Arg Ser Arg Lys Phe Phe Thr Gly 
        195                 200                 205             


Ser Leu Ala Glu Val Glu Lys Ser Asn Ser Gln Val Val Glu Glu Gln 
    210                 215                 220                 


Ser Tyr Leu Leu Asn Ile Ala Glu Val Gln Ala Val Ser Arg Cys Asp 
225                 230                 235                 240 


Tyr Phe Leu Ala Lys Ile Lys Gln Ala Asp Val Ala Leu Leu Glu Glu 
                245                 250                 255     


Thr Ala Asp Glu Glu Glu Pro Glu Leu Thr Ala Ser Leu Pro Arg Glu 
            260                 265                 270         


Leu Thr Leu Gln Asp Val Glu Leu Leu Lys Val Gly His Val Gly Pro 
        275                 280                 285             


Leu Gln Ile Gly Gln Ala Val Lys Lys Pro Arg Thr Val Asn Val Glu 
    290                 295                 300                 


Asp Ser Trp Ala Met Glu Ala Thr Ala Ser Ala Ala Ser Thr Ser Val 
305                 310                 315                 320 


Thr Phe Arg Glu Met Asp Met Ser Pro Glu Glu Val Val Ala Ser Pro 
                325                 330                 335     


Arg Ala Ser Pro Ala Lys Gln Arg Gly Pro Glu Ala Ala Ser Asn Ile 
            340                 345                 350         


Gln Gln Cys Leu Phe Leu Lys Lys Met Gly Ala Lys Gly Ser Thr Pro 
        355                 360                 365             


Gly Met Phe Asn Leu Pro Val Ser Leu Tyr Val Thr Ser Gln Gly Glu 
    370                 375                 380                 


Val Leu Val Ala Asp Arg Gly Asn Tyr Arg Ile Gln Val Phe Thr Arg 
385                 390                 395                 400 


Lys Gly Phe Leu Lys Glu Ile Arg Arg Ser Pro Ser Gly Ile Asp Ser 
                405                 410                 415     


Phe Val Leu Ser Phe Leu Gly Ala Asp Leu Pro Asn Leu Thr Pro Leu 
            420                 425                 430         


Ser Val Ala Met Asn Cys Gln Gly Leu Ile Gly Val Thr Asp Ser Tyr 
        435                 440                 445             


Asp Asn Ser Leu Lys Val Tyr Thr Leu Asp Gly His Cys Val Ala Cys 
    450                 455                 460                 


His Arg Ser Gln Leu Ser Lys Pro Trp Gly Ile Thr Ala Leu Pro Ser 
465                 470                 475                 480 


Gly Gln Phe Val Val Thr Asp Val Glu Gly Gly Lys Leu Trp Cys Phe 
                485                 490                 495     


Thr Val Asp Arg Gly Ser Gly Val Val Lys Tyr Ser Cys Leu Cys Ser 
            500                 505                 510         


Ala Val Arg Pro Lys Phe Val Thr Cys Asp Ala Glu Gly Thr Val Tyr 
        515                 520                 525             


Phe Thr Gln Gly Leu Gly Leu Asn Leu Glu Asn Arg Gln Asn Glu His 
    530                 535                 540                 


His Leu Glu Gly Gly Phe Ser Ile Gly Ser Val Gly Pro Asp Gly Gln 
545                 550                 555                 560 


Leu Gly Arg Gln Ile Ser His Phe Phe Ser Glu Asn Glu Asp Phe Arg 
                565                 570                 575     


Cys Ile Ala Gly Met Cys Val Asp Ala Arg Gly Asp Leu Ile Val Ala 
            580                 585                 590         


Asp Ser Ser Arg Lys Glu Ile Leu His Phe Pro Lys Gly Gly Gly Tyr 
        595                 600                 605             


Ser Val Leu Ile Arg Glu Gly Leu Thr Cys Pro Val Gly Ile Ala Leu 
    610                 615                 620                 


Thr Pro Lys Gly Gln Leu Leu Val Leu Asp Cys Trp Asp His Cys Ile 
625                 630                 635                 640 


Lys Ile Tyr Ser Tyr His Leu Arg Arg Tyr Ser Thr Pro 
                645                 650             


<210>  103
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Ala Thr Arg Arg Leu Gly Val Gly Glu Thr Leu Gly Ala Leu Asn 
1               5                   10                  15      


Ala Ala Leu Gly Pro Gly Gly Pro Val Trp Thr Lys Glu Thr Arg Thr 
            20                  25                  30          


Arg His Leu Arg Ser Arg Asp Phe Leu Ala Pro His Arg Ala Leu Gln 
        35                  40                  45              


Ala Arg Phe Asp Asp Gly Gln Val Pro Glu His Leu Leu His Ala Leu 
    50                  55                  60                  


Ala Cys Leu Gln Gly Pro Gly Val Ala Pro Val Leu Arg Cys Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Gly Leu Ser Leu Gln Leu Gln Arg Ser Ala Val Phe Glu 
                85                  90                  95      


Arg Val Leu Ser Ala Val Ala Ala Tyr Ala Thr Pro Ala Ser Pro Ala 
            100                 105                 110         


Ser Leu Gly Gln Arg Val Leu Leu His Cys Pro Ala Leu Arg Ser Ser 
        115                 120                 125             


Pro Cys Ala Leu Thr Gly Cys Ala Cys Ala 
    130                 135             


<210>  104
<211>  2355
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Asn Ile Asp Arg Pro  Lys Gly Leu 
    1625                 1630                 1635             


Ala Phe  Thr Asp Val Asp Val  Asp Ser Ile Lys Ile  Ala Trp Glu 
    1640                 1645                 1650             


Ser Pro  Gln Gly Gln Val Ser  Arg Tyr Arg Val Thr  Tyr Ser Ser 
    1655                 1660                 1665             


Pro Glu  Asp Gly Ile His Glu  Leu Phe Pro Ala Pro  Asp Gly Glu 
    1670                 1675                 1680             


Glu Asp  Thr Ala Glu Leu Gln  Gly Leu Arg Pro Gly  Ser Glu Tyr 
    1685                 1690                 1695             


Thr Val  Ser Val Val Ala Leu  His Asp Asp Met Glu  Ser Gln Pro 
    1700                 1705                 1710             


Leu Ile  Gly Thr Gln Ser Thr  Ala Ile Pro Ala Pro  Thr Asp Leu 
    1715                 1720                 1725             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1730                 1735                 1740             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1745                 1750                 1755             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1760                 1765                 1770             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1775                 1780                 1785             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1790                 1795                 1800             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1805                 1810                 1815             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1820                 1825                 1830             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1835                 1840                 1845             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1850                 1855                 1860             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1865                 1870                 1875             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1880                 1885                 1890             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1895                 1900                 1905             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1910                 1915                 1920             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1925                 1930                 1935             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1940                 1945                 1950             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1955                 1960                 1965             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1970                 1975                 1980             


Pro Leu  Ile Gly Arg Lys Lys  Thr Asp Glu Leu Pro  Gln Leu Val 
    1985                 1990                 1995             


Thr Leu  Pro His Pro Asn Leu  His Gly Pro Glu Ile  Leu Asp Val 
    2000                 2005                 2010             


Pro Ser  Thr Val Gln Lys Thr  Pro Phe Val Thr His  Pro Gly Tyr 
    2015                 2020                 2025             


Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly Thr Ser  Gly Gln Gln 
    2030                 2035                 2040             


Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu Glu His  Gly Phe Arg 
    2045                 2050                 2055             


Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro Ile Arg  His Arg Pro 
    2060                 2065                 2070             


Arg Pro  Tyr Pro Pro Asn Val  Gly Gln Glu Ala Leu  Ser Gln Thr 
    2075                 2080                 2085             


Thr Ile  Ser Trp Ala Pro Phe  Gln Asp Thr Ser Glu  Tyr Ile Ile 
    2090                 2095                 2100             


Ser Cys  His Pro Val Gly Thr  Asp Glu Glu Pro Leu  Gln Phe Arg 
    2105                 2110                 2115             


Val Pro  Gly Thr Ser Thr Ser  Ala Thr Leu Thr Gly  Leu Thr Arg 
    2120                 2125                 2130             


Gly Ala  Thr Tyr Asn Ile Ile  Val Glu Ala Leu Lys  Asp Gln Gln 
    2135                 2140                 2145             


Arg His  Lys Val Arg Glu Glu  Val Val Thr Val Gly  Asn Ser Val 
    2150                 2155                 2160             


Asn Glu  Gly Leu Asn Gln Pro  Thr Asp Asp Ser Cys  Phe Asp Pro 
    2165                 2170                 2175             


Tyr Thr  Val Ser His Tyr Ala  Val Gly Asp Glu Trp  Glu Arg Met 
    2180                 2185                 2190             


Ser Glu  Ser Gly Phe Lys Leu  Leu Cys Gln Cys Leu  Gly Phe Gly 
    2195                 2200                 2205             


Ser Gly  His Phe Arg Cys Asp  Ser Ser Arg Trp Cys  His Asp Asn 
    2210                 2215                 2220             


Gly Val  Asn Tyr Lys Ile Gly  Glu Lys Trp Asp Arg  Gln Gly Glu 
    2225                 2230                 2235             


Asn Gly  Gln Met Met Ser Cys  Thr Cys Leu Gly Asn  Gly Lys Gly 
    2240                 2245                 2250             


Glu Phe  Lys Cys Asp Pro His  Glu Ala Thr Cys Tyr  Asp Asp Gly 
    2255                 2260                 2265             


Lys Thr  Tyr His Val Gly Glu  Gln Trp Gln Lys Glu  Tyr Leu Gly 
    2270                 2275                 2280             


Ala Ile  Cys Ser Cys Thr Cys  Phe Gly Gly Gln Arg  Gly Trp Arg 
    2285                 2290                 2295             


Cys Asp  Asn Cys Arg Arg Pro  Gly Gly Glu Pro Ser  Pro Glu Gly 
    2300                 2305                 2310             


Thr Thr  Gly Gln Ser Tyr Asn  Gln Tyr Ser Gln Arg  Tyr His Gln 
    2315                 2320                 2325             


Arg Thr  Asn Thr Asn Val Asn  Cys Pro Ile Glu Cys  Phe Met Pro 
    2330                 2335                 2340             


Leu Asp  Val Gln Ala Asp Arg  Glu Asp Ser Arg Glu  
    2345                 2350                 2355 


<210>  105
<211>  596
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ser Leu Ser Met Arg Asp Pro Val Ile Pro Gly Thr Ser Met Ala 
1               5                   10                  15      


Tyr His Pro Phe Leu Pro His Arg Ala Pro Asp Phe Ala Met Ser Ala 
            20                  25                  30          


Val Leu Gly His Gln Pro Pro Phe Phe Pro Ala Leu Thr Leu Pro Pro 
        35                  40                  45              


Asn Gly Ala Ala Ala Leu Ser Leu Pro Gly Ala Leu Ala Lys Pro Ile 
    50                  55                  60                  


Met Asp Gln Leu Val Gly Ala Ala Glu Thr Gly Ile Pro Phe Ser Ser 
65                  70                  75                  80  


Leu Gly Pro Gln Ala His Leu Arg Pro Leu Lys Thr Met Glu Pro Glu 
                85                  90                  95      


Glu Glu Val Glu Asp Asp Pro Lys Val His Leu Glu Ala Lys Glu Leu 
            100                 105                 110         


Trp Asp Gln Phe His Lys Arg Gly Thr Glu Met Val Ile Thr Lys Ser 
        115                 120                 125             


Gly Arg Arg Met Phe Pro Pro Phe Lys Val Arg Cys Ser Gly Leu Asp 
    130                 135                 140                 


Lys Lys Ala Lys Tyr Ile Leu Leu Met Asp Ile Ile Ala Ala Asp Asp 
145                 150                 155                 160 


Cys Arg Tyr Lys Phe His Asn Ser Arg Trp Met Val Ala Gly Lys Ala 
                165                 170                 175     


Asp Pro Glu Met Pro Lys Arg Met Tyr Ile His Pro Asp Ser Pro Ala 
            180                 185                 190         


Thr Gly Glu Gln Trp Met Ser Lys Val Val Thr Phe His Lys Leu Lys 
        195                 200                 205             


Leu Thr Asn Asn Ile Ser Asp Lys His Gly Phe Thr Leu Ala Phe Pro 
    210                 215                 220                 


Ser Asp His Ala Thr Trp Gln Gly Asn Tyr Ser Phe Gly Thr Gln Thr 
225                 230                 235                 240 


Ile Leu Asn Ser Met His Lys Tyr Gln Pro Arg Phe His Ile Val Arg 
                245                 250                 255     


Ala Asn Asp Ile Leu Lys Leu Pro Tyr Ser Thr Phe Arg Thr Tyr Leu 
            260                 265                 270         


Phe Pro Glu Thr Glu Phe Ile Ala Val Thr Ala Tyr Gln Asn Asp Lys 
        275                 280                 285             


Ile Thr Gln Leu Lys Ile Asp Asn Asn Pro Phe Ala Lys Gly Phe Arg 
    290                 295                 300                 


Asp Thr Gly Asn Gly Arg Arg Glu Lys Arg Lys Gln Leu Thr Leu Gln 
305                 310                 315                 320 


Ser Met Arg Val Phe Asp Glu Arg His Lys Lys Glu Asn Gly Thr Ser 
                325                 330                 335     


Asp Glu Ser Ser Ser Glu Gln Ala Ala Phe Asn Cys Phe Ala Gln Ala 
            340                 345                 350         


Ser Ser Pro Ala Ala Ser Thr Val Gly Thr Ser Asn Leu Lys Asp Leu 
        355                 360                 365             


Cys Pro Ser Glu Gly Glu Ser Asp Ala Glu Ala Glu Ser Lys Glu Glu 
    370                 375                 380                 


His Gly Pro Glu Ala Cys Asp Ala Ala Lys Ile Ser Thr Thr Thr Ser 
385                 390                 395                 400 


Glu Glu Pro Cys Arg Asp Lys Gly Ser Pro Ala Val Lys Ala His Leu 
                405                 410                 415     


Phe Ala Ala Glu Arg Pro Arg Asp Ser Gly Arg Leu Asp Lys Ala Ser 
            420                 425                 430         


Pro Asp Ser Arg His Ser Pro Ala Thr Ile Ser Ser Ser Thr Arg Gly 
        435                 440                 445             


Leu Gly Ala Glu Glu Arg Arg Ser Pro Val Arg Glu Gly Thr Ala Pro 
    450                 455                 460                 


Ala Lys Val Glu Glu Ala Arg Ala Leu Pro Gly Lys Glu Ala Phe Ala 
465                 470                 475                 480 


Pro Leu Thr Val Gln Thr Asp Ala Ala Arg Ser Ser Val His Arg His 
                485                 490                 495     


Pro Phe Leu Asn Leu Asn Thr Met Arg Pro Arg Leu Arg Tyr Ser Pro 
            500                 505                 510         


Tyr Ser Ile Pro Val Pro Val Pro Asp Gly Ser Ser Leu Leu Thr Thr 
        515                 520                 525             


Ala Leu Ala Ala Ser Pro Ala Ser Val Ala Val Asp Ser Gly Ser Glu 
    530                 535                 540                 


Leu Asn Ser Arg Ser Ser Thr Leu Ser Ser Ser Ser Met Ser Leu Ser 
545                 550                 555                 560 


Pro Lys Leu Cys Ala Glu Lys Glu Ala Ala Thr Ser Glu Leu Gln Ser 
                565                 570                 575     


Ile Gln Arg Leu Val Ser Gly Leu Glu Ala Lys Pro Asp Arg Ser Arg 
            580                 585                 590         


Ser Ala Ser Pro 
        595     


<210>  106
<211>  1298
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Val Thr Gly Ala Gly Val Val Leu Gly Asp Asn Asp Ala Pro Pro 
1               5                   10                  15      


Gly Thr Ser Ala Ser Gln Glu Gly Asp Gly Ser Val Asn Asp Gly Thr 
            20                  25                  30          


Glu Gly Glu Ser Ala Val Thr Ser Thr Gly Ile Thr Glu Asp Gly Glu 
        35                  40                  45              


Gly Pro Ala Ser Cys Thr Gly Ser Glu Asp Ser Ser Glu Gly Phe Ala 
    50                  55                  60                  


Ile Ser Ser Glu Ser Glu Glu Asn Gly Glu Ser Ala Met Asp Ser Thr 
65                  70                  75                  80  


Val Ala Lys Glu Gly Thr Asn Val Pro Leu Val Ala Ala Gly Pro Cys 
                85                  90                  95      


Asp Asp Glu Gly Ile Val Thr Ser Thr Gly Ala Lys Glu Glu Asp Glu 
            100                 105                 110         


Glu Gly Glu Asp Val Val Thr Ser Thr Gly Arg Gly Asn Glu Ile Gly 
        115                 120                 125             


His Ala Ser Thr Cys Thr Gly Leu Gly Glu Glu Ser Glu Gly Val Leu 
    130                 135                 140                 


Ile Cys Glu Ser Ala Glu Gly Asp Ser Gln Ile Gly Thr Val Val Glu 
145                 150                 155                 160 


His Val Glu Ala Glu Ala Gly Ala Ala Ile Met Asn Ala Asn Glu Asn 
                165                 170                 175     


Asn Val Asp Ser Met Ser Gly Thr Glu Lys Gly Ser Lys Asp Thr Asp 
            180                 185                 190         


Ile Cys Ser Ser Ala Lys Gly Ile Val Glu Ser Ser Val Thr Ser Ala 
        195                 200                 205             


Val Ser Gly Lys Asp Glu Val Thr Pro Val Pro Gly Gly Cys Glu Gly 
    210                 215                 220                 


Pro Met Thr Ser Ala Ala Ser Asp Gln Ser Asp Ser Gln Leu Glu Lys 
225                 230                 235                 240 


Val Glu Asp Thr Thr Ile Ser Thr Gly Leu Val Gly Gly Ser Tyr Asp 
                245                 250                 255     


Val Leu Val Ser Gly Glu Val Pro Glu Cys Glu Val Ala His Thr Ser 
            260                 265                 270         


Pro Ser Glu Lys Glu Asp Glu Asp Ile Ile Thr Ser Val Glu Asn Glu 
        275                 280                 285             


Glu Cys Asp Gly Leu Met Ala Thr Thr Ala Ser Gly Asp Ile Thr Asn 
    290                 295                 300                 


Gln Asn Ser Leu Ala Gly Gly Lys Asn Gln Gly Lys Val Leu Ile Ile 
305                 310                 315                 320 


Ser Thr Ser Thr Thr Asn Asp Tyr Thr Pro Gln Val Ser Ala Ile Thr 
                325                 330                 335     


Asp Val Glu Gly Gly Leu Ser Asp Ala Leu Arg Thr Glu Glu Asn Met 
            340                 345                 350         


Glu Gly Thr Arg Val Thr Thr Glu Glu Phe Glu Ala Pro Met Pro Ser 
        355                 360                 365             


Ala Val Ser Gly Asp Asp Ser Gln Leu Thr Ala Ser Arg Ser Glu Glu 
    370                 375                 380                 


Lys Asp Glu Cys Ala Met Ile Ser Thr Ser Ile Gly Glu Glu Phe Glu 
385                 390                 395                 400 


Leu Pro Ile Ser Ser Ala Thr Thr Ile Lys Cys Ala Glu Ser Leu Gln 
                405                 410                 415     


Pro Val Ala Ala Ala Val Glu Glu Arg Ala Thr Gly Pro Val Leu Ile 
            420                 425                 430         


Ser Thr Ala Asp Phe Glu Gly Pro Met Pro Ser Ala Pro Pro Glu Ala 
        435                 440                 445             


Glu Ser Pro Leu Ala Ser Thr Ser Lys Glu Glu Lys Asp Glu Cys Ala 
    450                 455                 460                 


Leu Ile Ser Thr Ser Ile Ala Glu Glu Cys Glu Ala Ser Val Ser Gly 
465                 470                 475                 480 


Val Val Val Glu Ser Glu Asn Glu Arg Ala Gly Thr Val Met Glu Glu 
                485                 490                 495     


Lys Asp Gly Ser Gly Ile Ile Ser Thr Ser Ser Val Glu Asp Cys Glu 
            500                 505                 510         


Gly Pro Val Ser Ser Ala Val Pro Gln Glu Glu Gly Asp Pro Ser Val 
        515                 520                 525             


Thr Pro Ala Glu Glu Met Gly Asp Thr Ala Met Ile Ser Thr Ser Thr 
    530                 535                 540                 


Ser Glu Gly Cys Glu Ala Val Met Ile Gly Ala Val Leu Gln Asp Glu 
545                 550                 555                 560 


Asp Arg Leu Thr Ile Thr Arg Val Glu Asp Leu Ser Asp Ala Ala Ile 
                565                 570                 575     


Ile Ser Thr Ser Thr Ala Glu Cys Met Pro Ile Ser Ala Ser Ile Asp 
            580                 585                 590         


Arg His Glu Glu Asn Gln Leu Thr Ala Asp Asn Pro Glu Gly Asn Gly 
        595                 600                 605             


Asp Leu Ser Ala Thr Glu Val Ser Lys His Lys Val Pro Met Pro Ser 
    610                 615                 620                 


Leu Ile Ala Glu Asn Asn Cys Arg Cys Pro Gly Pro Val Arg Gly Gly 
625                 630                 635                 640 


Lys Glu Pro Gly Pro Val Leu Ala Val Ser Thr Glu Glu Gly His Asn 
                645                 650                 655     


Gly Pro Ser Val His Lys Pro Ser Ala Gly Gln Gly His Pro Ser Ala 
            660                 665                 670         


Val Cys Ala Glu Lys Glu Glu Lys His Gly Lys Glu Cys Pro Glu Ile 
        675                 680                 685             


Gly Pro Phe Ala Gly Arg Gly Gln Lys Glu Ser Thr Leu His Leu Ile 
    690                 695                 700                 


Asn Ala Glu Glu Lys Asn Val Leu Leu Asn Ser Leu Gln Lys Glu Asp 
705                 710                 715                 720 


Lys Ser Pro Glu Thr Gly Thr Ala Gly Gly Ser Ser Thr Ala Ser Tyr 
                725                 730                 735     


Ser Ala Gly Arg Gly Leu Glu Gly Asn Ala Asn Ser Pro Ala His Leu 
            740                 745                 750         


Arg Gly Pro Glu Gln Thr Ser Gly Gln Thr Ala Lys Asp Pro Ser Val 
        755                 760                 765             


Ser Ile Arg Tyr Leu Ala Ala Val Asn Thr Gly Ala Ile Lys Ala Asp 
    770                 775                 780                 


Asp Met Pro Pro Val Gln Gly Thr Val Ala Glu His Ser Phe Leu Pro 
785                 790                 795                 800 


Ala Glu Gln Gln Gly Ser Glu Asp Asn Leu Lys Thr Ser Thr Thr Lys 
                805                 810                 815     


Cys Ile Thr Gly Gln Glu Ser Lys Ile Ala Pro Ser His Thr Met Ile 
            820                 825                 830         


Pro Pro Ala Thr Tyr Ser Val Ala Leu Leu Ala Pro Lys Cys Glu Gln 
        835                 840                 845             


Asp Leu Thr Ile Lys Asn Asp Tyr Ser Gly Lys Trp Thr Asp Gln Ala 
    850                 855                 860                 


Ser Ala Glu Lys Thr Gly Asp Asp Asn Ser Thr Arg Lys Ser Phe Pro 
865                 870                 875                 880 


Glu Glu Gly Asp Ile Met Val Thr Val Ser Ser Glu Glu Asn Val Cys 
                885                 890                 895     


Asp Ile Gly Asn Glu Glu Ser Pro Leu Asn Val Leu Gly Gly Leu Lys 
            900                 905                 910         


Leu Lys Ala Asn Leu Lys Met Glu Ala Tyr Val Pro Ser Glu Glu Glu 
        915                 920                 925             


Lys Asn Gly Glu Ile Leu Ala Pro Pro Glu Ser Leu Cys Gly Gly Lys 
    930                 935                 940                 


Pro Ser Gly Ile Ala Glu Leu Gln Arg Glu Pro Leu Leu Val Asn Glu 
945                 950                 955                 960 


Ser Leu Asn Val Glu Asn Ser Gly Phe Arg Thr Asn Glu Glu Ile His 
                965                 970                 975     


Ser Glu Ser Tyr Asn Lys Gly Glu Ile Ser Ser Gly Arg Lys Asp Asn 
            980                 985                 990         


Ala Glu Ala Ile Ser Gly His Ser  Val Glu Ala Asp Pro  Lys Glu Val 
        995                 1000                 1005             


Glu Glu  Glu Glu Arg His Met  Pro Lys Arg Lys Arg  Lys Gln His 
    1010                 1015                 1020             


Tyr Leu  Ser Ser Glu Asp Glu  Pro Asp Asp Asn Pro  Asp Val Leu 
    1025                 1030                 1035             


Asp Ser  Arg Ile Glu Thr Ala  Gln Arg Gln Cys Pro  Glu Thr Glu 
    1040                 1045                 1050             


Pro His  Asp Thr Lys Glu Glu  Asn Ser Arg Asp Leu  Glu Glu Leu 
    1055                 1060                 1065             


Pro Lys  Thr Ser Ser Glu Thr  Asn Ser Thr Thr Ser  Arg Val Met 
    1070                 1075                 1080             


Glu Glu  Lys Asp Glu Tyr Ser  Ser Ser Glu Thr Thr  Gly Glu Lys 
    1085                 1090                 1095             


Pro Glu  Gln Asn Asp Asp Asp  Thr Ile Lys Ser Gln  Glu Glu Asp 
    1100                 1105                 1110             


Gln Pro  Ile Ile Ile Lys Arg  Lys Arg Gly Arg Pro  Arg Lys Tyr 
    1115                 1120                 1125             


Pro Val  Glu Thr Thr Leu Lys  Met Lys Asp Asp Ser  Lys Thr Asp 
    1130                 1135                 1140             


Thr Gly  Ile Val Thr Val Glu  Gln Ser Pro Ser Ser  Ser Lys Leu 
    1145                 1150                 1155             


Lys Val  Met Gln Thr Asp Glu  Ser Asn Lys Glu Thr  Ala Asn Leu 
    1160                 1165                 1170             


Gln Glu  Arg Ser Ile Ser Asn  Asp Asp Gly Glu Glu  Lys Ile Val 
    1175                 1180                 1185             


Thr Ser  Val Arg Arg Arg Gly  Arg Lys Pro Lys Arg  Ser Leu Thr 
    1190                 1195                 1200             


Val Ser  Asp Asp Ala Glu Ser  Ser Glu Pro Glu Arg  Lys Arg Gln 
    1205                 1210                 1215             


Lys Ser  Val Ser Asp Pro Val  Glu Asp Lys Lys Glu  Gln Glu Ser 
    1220                 1225                 1230             


Asp Glu  Glu Glu Glu Glu Glu  Glu Glu Asp Glu Pro  Ser Gly Ala 
    1235                 1240                 1245             


Thr Thr  Arg Ser Thr Thr Arg  Ser Glu Ala Gln Arg  Ser Lys Thr 
    1250                 1255                 1260             


Gln Leu  Ser Pro Ser Ile Lys  Arg Lys Arg Glu Val  Ser Pro Pro 
    1265                 1270                 1275             


Gly Ala  Arg Thr Arg Gly Gln  Gln Arg Val Glu Glu  Ala Pro Val 
    1280                 1285                 1290             


Lys Lys  Ala Lys Arg 
    1295             


<210>  107
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  107

Leu Ala Ser Arg Ser Gly Ser Ser Arg Ala Ala Ala Ser Arg Gly Ser 
1               5                   10                  15      


Glu Arg Leu Pro Arg Gly Ser Val Cys Val Ala Gly Ala Ala Gly Ala 
            20                  25                  30          


Leu Ala Met Arg Thr Leu Trp Met Ala Leu Cys Ala Leu Ser Arg Leu 
        35                  40                  45              


Trp Pro Gly Ala Gln Ala Gly Cys Ala Glu Ala Gly Arg Cys Cys Pro 
    50                  55                  60                  


Gly Arg Asp Pro Ala Cys Phe Ala Arg Gly Trp Arg Leu Asp Arg Val 
65                  70                  75                  80  


Tyr Gly Thr Cys Phe Cys Asp Gln Ala Cys Arg Leu Thr Gly Asp Cys 
                85                  90                  95      


Cys Phe Asp Tyr Asp Arg Ala Cys Pro Ala Arg Pro Cys Phe Val Gly 
            100                 105                 110         


Glu Trp Ser Pro Trp Ser Gly Cys Ala Asp Gln Cys Lys Pro Thr Thr 
        115                 120                 125             


Arg Val Arg Arg Arg Ser Val Gln Gln Glu Pro Gln Asn Gly Gly Ala 
    130                 135                 140                 


Pro Cys Pro Pro Leu Glu Glu Arg Ala Gly Cys Leu Glu Tyr Ser Thr 
145                 150                 155                 160 


Pro Gln Gly Gln Asp Cys Gly His Thr Tyr Val Pro Ala Phe Ile Thr 
                165                 170                 175     


Thr Ser Ala Phe Asn Lys Glu Arg Thr Arg Gln Ala Thr Ser Pro His 
            180                 185                 190         


Trp Ser Thr His Thr Glu Asp Ala Gly Tyr Cys Met Glu Phe Lys Thr 
        195                 200                 205             


Glu Ser Leu Thr Pro His Cys Ala Leu Glu Asn Arg Pro Leu Thr Arg 
    210                 215                 220                 


Trp Met Gln Tyr Leu Arg Glu Gly Tyr Thr Val Cys Val Asp Cys Gln 
225                 230                 235                 240 


Pro Pro Ala Met Asn Ser Val Ser Leu Arg Cys Ser Gly Asp Gly Leu 
                245                 250                 255     


Asp Ser Asp Gly Asn Gln Thr Leu His Trp Gln Ala Ile Gly Asn Pro 
            260                 265                 270         


Arg Cys Gln Gly Thr Trp Lys Lys Val Arg Arg Val Asp Gln Cys Ser 
        275                 280                 285             


Cys Pro Ala Val His Ser Phe Ile Phe Ile 
    290                 295             


<210>  108
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Val Gly Lys His Leu Gly Ala Arg Lys Asp His Pro Gly Leu Lys 
1               5                   10                  15      


Ala Lys Glu Asn Asp Glu Asn Cys Gly Pro Thr Thr Thr Val Phe Val 
            20                  25                  30          


Gly Asn Ile Ser Glu Lys Ala Ser Asp Met Leu Ile Arg Gln Leu Leu 
        35                  40                  45              


Ala Lys Cys Gly Leu Val Leu Ser Trp Lys Arg Val Gln Gly Ala Ser 
    50                  55                  60                  


Gly Lys Leu Gln Ala Phe Gly Phe Cys Glu Tyr Lys Glu Pro Glu Ser 
65                  70                  75                  80  


Thr Leu Arg Ala Leu Arg Leu Leu His Asp Leu Gln Ile Gly Glu Lys 
                85                  90                  95      


Lys Leu Leu Val Lys Val Asp Ala Lys Thr Lys Ala Gln Leu Asp Glu 
            100                 105                 110         


Trp Lys Ala Lys Lys Lys Ala Ser Asn Gly Asn Ala Arg Pro Glu Thr 
        115                 120                 125             


Val Thr Asn Asp Asp Glu Glu Ala Leu Asp Glu Glu Thr Lys Arg Arg 
    130                 135                 140                 


Asp Gln Met Ile Lys Gly Ala Ile Glu Val Leu Ile Arg Glu Tyr Ser 
145                 150                 155                 160 


Ser Glu Leu Asn Ala Pro Ser Gln Glu Ser Asp Ser His Pro Arg Lys 
                165                 170                 175     


Lys Lys Lys Glu Lys Lys Glu Asp Ile Phe Arg Arg Phe Pro Val Ala 
            180                 185                 190         


Pro Leu Ile Pro Tyr Pro Leu Ile Thr Lys Glu Asp Ile Asn Ala Ile 
        195                 200                 205             


Glu Met Glu Glu Asp Lys Arg Asp Leu Ile Ser Arg Glu Ile Ser Lys 
    210                 215                 220                 


Phe Arg Asp Thr His Lys Lys Leu Glu Glu Glu Lys Gly Lys Lys Glu 
225                 230                 235                 240 


Lys Glu Arg Gln Glu Ile Glu Lys Glu Arg Arg Glu Arg Glu Arg Glu 
                245                 250                 255     


Arg Glu Arg Glu Arg Glu Arg Arg Glu Arg Glu Arg Glu Arg Glu Arg 
            260                 265                 270         


Glu Arg Glu Arg Glu Lys Glu Lys Glu Arg Glu Arg Glu Arg Glu Arg 
        275                 280                 285             


Asp Arg Asp Arg Asp Arg Thr Lys Glu Arg Asp Arg Asp Arg Asp Arg 
    290                 295                 300                 


Glu Arg Asp Arg Asp Arg Asp Arg Glu Arg Ser Ser Asp Arg Asn Lys 
305                 310                 315                 320 


Asp Arg Ser Arg Ser Arg Glu Lys Ser Arg Asp Arg Glu Arg Glu Arg 
                325                 330                 335     


Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg 
            340                 345                 350         


Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Lys 
        355                 360                 365             


Asp Lys Lys Arg Asp Arg Glu Glu Asp Glu Glu Asp Ala Tyr Glu Arg 
    370                 375                 380                 


Arg Lys Leu Glu Arg Lys Leu Arg Glu Lys Glu Ala Ala Tyr Gln Glu 
385                 390                 395                 400 


Arg Leu Lys Asn Trp Glu Ile Arg Glu Arg Lys Lys Thr Arg Glu Tyr 
                405                 410                 415     


Glu Lys Glu Ala Glu Arg Glu Glu Glu Arg Arg Arg Glu Met Ala Lys 
            420                 425                 430         


Glu Ala Lys Arg Leu Lys Glu Phe Leu Glu Asp Tyr Asp Asp Asp Arg 
        435                 440                 445             


Asp Asp Pro Lys Tyr Tyr Arg Gly Ser Ala Leu Gln Lys Arg Leu Arg 
    450                 455                 460                 


Asp Arg Glu Lys Glu Met Glu Ala Asp Glu Arg Asp Arg Lys Arg Glu 
465                 470                 475                 480 


Lys Glu Glu Leu Glu Glu Ile Arg Gln Arg Leu Leu Ala Glu Gly His 
                485                 490                 495     


Pro Asp Pro Asp Ala Glu Leu Gln Arg Met Glu Gln Glu Ala Glu Arg 
            500                 505                 510         


Arg Arg Gln Pro Gln Ile Lys Gln Glu Pro Glu Ser Glu Glu Glu Glu 
        515                 520                 525             


Glu Glu Lys Gln Glu Lys Glu Glu Lys Arg Glu Glu Pro Met Glu Glu 
    530                 535                 540                 


Glu Glu Glu Pro Glu Gln Lys Pro Cys Leu Lys Pro Thr Leu Arg Pro 
545                 550                 555                 560 


Ile Ser Ser Ala Pro Ser Val Ser Ser Ala Ser Gly Asn Ala Thr Pro 
                565                 570                 575     


Asn Thr Pro Gly Asp Glu Ser Pro Cys Gly Ile Ile Ile Pro His Glu 
            580                 585                 590         


Asn Ser Pro Asp Gln Gln Gln Pro Glu Glu His Arg Pro Lys Ile Gly 
        595                 600                 605             


Leu Ser Leu Lys Leu Gly Ala Ser Asn Ser Pro Gly Gln Pro Asn Ser 
    610                 615                 620                 


Val Lys Arg Lys Lys Leu Pro Val Asp Ser Val Phe Asn Lys Phe Glu 
625                 630                 635                 640 


Asp Glu Asp Ser Asp Asp Val Pro Arg Lys Arg Lys Leu Val Pro Leu 
                645                 650                 655     


Asp Tyr Gly Glu Asp Asp Lys Asn Ala Thr Lys Gly Thr Val Asn Thr 
            660                 665                 670         


Glu Glu Lys Arg Lys His Ile Lys Ser Leu Ile Glu Lys Ile Pro Thr 
        675                 680                 685             


Ala Lys Pro Glu Leu Phe Ala Tyr Pro Leu Asp Trp Ser Ile Val Asp 
    690                 695                 700                 


Ser Ile Leu Met Glu Arg Arg Ile Arg Pro Trp Ile Asn Lys Lys Ile 
705                 710                 715                 720 


Ile Glu Tyr Ile Gly Glu Glu Glu Ala Thr Leu Val Asp Phe Val Cys 
                725                 730                 735     


Ser Lys Val Met Ala His Ser Ser Pro Gln Ser Ile Leu Asp Asp Val 
            740                 745                 750         


Ala Met Val Leu Asp Glu Glu Ala Glu Val Phe Ile Val Lys Met Trp 
        755                 760                 765             


Arg Leu Leu Ile Tyr Glu Thr Glu Ala Lys Lys Ile Gly Leu Val Lys 
    770                 775                 780                 


<210>  109
<211>  735
<212>  PRT
<213>  Homo sapiens

<400>  109

Lys Cys Gly Leu Val Leu Ser Trp Lys Arg Val Gln Gly Ala Ser Gly 
1               5                   10                  15      


Lys Leu Gln Ala Phe Gly Phe Cys Glu Tyr Lys Glu Pro Glu Ser Thr 
            20                  25                  30          


Leu Arg Ala Leu Arg Leu Leu His Asp Leu Gln Ile Gly Glu Lys Lys 
        35                  40                  45              


Leu Leu Val Lys Val Asp Ala Lys Thr Lys Ala Gln Leu Asp Glu Trp 
    50                  55                  60                  


Lys Ala Lys Lys Lys Ala Ser Asn Gly Asn Ala Arg Pro Glu Thr Val 
65                  70                  75                  80  


Thr Asn Asp Asp Glu Glu Ala Leu Asp Glu Glu Thr Lys Arg Arg Asp 
                85                  90                  95      


Gln Met Ile Lys Gly Ala Ile Glu Val Leu Ile Arg Glu Tyr Ser Ser 
            100                 105                 110         


Glu Leu Asn Ala Pro Ser Gln Glu Ser Asp Ser His Pro Arg Lys Lys 
        115                 120                 125             


Lys Lys Glu Lys Lys Glu Asp Ile Phe Arg Arg Phe Pro Val Ala Pro 
    130                 135                 140                 


Leu Ile Pro Tyr Pro Leu Ile Thr Lys Glu Asp Ile Asn Ala Ile Glu 
145                 150                 155                 160 


Met Glu Glu Asp Lys Arg Asp Leu Ile Ser Arg Glu Ile Ser Lys Phe 
                165                 170                 175     


Arg Asp Thr His Lys Lys Leu Glu Glu Glu Lys Gly Lys Lys Glu Lys 
            180                 185                 190         


Glu Arg Gln Glu Ile Glu Lys Glu Arg Arg Glu Arg Glu Arg Glu Arg 
        195                 200                 205             


Glu Arg Glu Arg Glu Arg Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu 
    210                 215                 220                 


Arg Glu Arg Glu Lys Glu Lys Glu Arg Glu Arg Glu Arg Glu Arg Asp 
225                 230                 235                 240 


Arg Asp Arg Asp Arg Thr Lys Glu Arg Asp Arg Asp Arg Asp Arg Glu 
                245                 250                 255     


Arg Asp Arg Asp Arg Asp Arg Glu Arg Ser Ser Asp Arg Asn Lys Asp 
            260                 265                 270         


Arg Ser Arg Ser Arg Glu Lys Ser Arg Asp Arg Glu Arg Glu Arg Glu 
        275                 280                 285             


Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu 
    290                 295                 300                 


Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Lys Asp 
305                 310                 315                 320 


Lys Lys Arg Asp Arg Glu Glu Asp Glu Glu Asp Ala Tyr Glu Arg Arg 
                325                 330                 335     


Lys Leu Glu Arg Lys Leu Arg Glu Lys Glu Ala Ala Tyr Gln Glu Arg 
            340                 345                 350         


Leu Lys Asn Trp Glu Ile Arg Glu Arg Lys Lys Thr Arg Glu Tyr Glu 
        355                 360                 365             


Lys Glu Ala Glu Arg Glu Glu Glu Arg Arg Arg Glu Met Ala Lys Glu 
    370                 375                 380                 


Ala Lys Arg Leu Lys Glu Phe Leu Glu Asp Tyr Asp Asp Asp Arg Asp 
385                 390                 395                 400 


Asp Pro Lys Tyr Tyr Arg Gly Ser Ala Leu Gln Lys Arg Leu Arg Asp 
                405                 410                 415     


Arg Glu Lys Glu Met Glu Ala Asp Glu Arg Asp Arg Lys Arg Glu Lys 
            420                 425                 430         


Glu Glu Leu Glu Glu Ile Arg Gln Arg Leu Leu Ala Glu Gly His Pro 
        435                 440                 445             


Asp Pro Asp Ala Glu Leu Gln Arg Met Glu Gln Glu Ala Glu Arg Arg 
    450                 455                 460                 


Arg Gln Pro Gln Ile Lys Gln Glu Pro Glu Ser Glu Glu Glu Glu Glu 
465                 470                 475                 480 


Glu Lys Gln Glu Lys Glu Glu Lys Arg Glu Glu Pro Met Glu Glu Glu 
                485                 490                 495     


Glu Glu Pro Glu Gln Lys Pro Cys Leu Lys Pro Thr Leu Arg Pro Ile 
            500                 505                 510         


Ser Ser Ala Pro Ser Val Ser Ser Ala Ser Gly Asn Ala Thr Pro Asn 
        515                 520                 525             


Thr Pro Gly Asp Glu Ser Pro Cys Gly Ile Ile Ile Pro His Glu Asn 
    530                 535                 540                 


Ser Pro Asp Gln Gln Gln Pro Glu Glu His Arg Pro Lys Ile Gly Leu 
545                 550                 555                 560 


Ser Leu Lys Leu Gly Ala Ser Asn Ser Pro Gly Gln Pro Asn Ser Val 
                565                 570                 575     


Lys Arg Lys Lys Leu Pro Val Asp Ser Val Phe Asn Lys Phe Glu Asp 
            580                 585                 590         


Glu Asp Ser Asp Asp Val Pro Arg Lys Arg Lys Leu Val Pro Leu Asp 
        595                 600                 605             


Tyr Gly Glu Asp Asp Lys Asn Ala Thr Lys Gly Thr Val Asn Thr Glu 
    610                 615                 620                 


Glu Lys Arg Lys His Ile Lys Ser Leu Ile Glu Lys Ile Pro Thr Ala 
625                 630                 635                 640 


Lys Pro Glu Leu Phe Ala Tyr Pro Leu Asp Trp Ser Ile Val Asp Ser 
                645                 650                 655     


Ile Leu Met Glu Arg Arg Ile Arg Pro Trp Ile Asn Lys Lys Ile Ile 
            660                 665                 670         


Glu Tyr Ile Gly Glu Glu Glu Ala Thr Leu Val Asp Phe Val Cys Ser 
        675                 680                 685             


Lys Val Met Ala His Ser Ser Pro Gln Ser Ile Leu Asp Asp Val Ala 
    690                 695                 700                 


Met Val Leu Asp Glu Glu Ala Glu Val Phe Ile Val Lys Met Trp Arg 
705                 710                 715                 720 


Leu Leu Ile Tyr Glu Thr Glu Ala Lys Lys Ile Gly Leu Val Lys 
                725                 730                 735 


<210>  110
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Glu Thr Glu Ser Gly Asn Gln Glu Lys Val Met Glu Glu Glu Ser 
1               5                   10                  15      


Thr Glu Lys Lys Lys Glu Val Glu Lys Lys Lys Arg Ser Arg Val Lys 
            20                  25                  30          


Gln Val Leu Ala Asp Ile Ala Lys Gln Val Asp Phe Trp Phe Gly Asp 
        35                  40                  45              


Ala Asn Leu His Lys Asp Arg Phe Leu Arg Glu Gln Ile Glu Lys Ser 
    50                  55                  60                  


Arg Asp Gly Tyr Val Asp Ile Ser Leu Leu Val Ser Phe Asn Lys Met 
65                  70                  75                  80  


Lys Lys Leu Thr Thr Asp Gly Lys Leu Ile Ala Arg Ala Leu Arg Ser 
                85                  90                  95      


Ser Ala Val Val Glu Leu Asp Leu Glu Gly Thr Arg Ile Arg Arg Lys 
            100                 105                 110         


Lys Pro Leu Gly Glu Arg Pro Lys Asp Glu Asp Glu Arg Thr Val Tyr 
        115                 120                 125             


Val Glu Leu Leu Pro Lys Asn Val Asn His Ser Trp Ile Glu Arg Val 
    130                 135                 140                 


Phe Gly Lys Cys Gly Asn Val Val Tyr Ile Ser Ile Pro His Tyr Lys 
145                 150                 155                 160 


Ser Thr Gly Asp Pro Lys Gly Phe Ala Phe Val Glu Phe Glu Thr Lys 
                165                 170                 175     


Glu Gln Ala Ala Lys Ala Ile Glu Phe Leu Asn Asn Pro Pro Glu Glu 
            180                 185                 190         


Ala Pro Arg Lys Pro Gly Ile Phe Pro Lys Thr Val Lys Asn Lys Pro 
        195                 200                 205             


Ile Pro Ala Leu Arg Val Val Glu Glu Lys Lys Lys Lys Lys Lys Lys 
    210                 215                 220                 


Lys Gly Arg Met Lys Lys Glu Asp Asn Ile Gln Ala Lys Glu Glu Asn 
225                 230                 235                 240 


Met Asp Thr Ser Asn Thr Ser Ile Ser Lys Met Lys Arg Ser Arg Pro 
                245                 250                 255     


Thr Ser Glu Gly Ser Asp Ile Glu Ser Thr Glu Pro Gln Lys Gln Cys 
            260                 265                 270         


Ser Lys Lys Lys Lys Lys Arg Asp Arg Val Glu Ala Ser Ser Leu Pro 
        275                 280                 285             


Glu Val Arg Thr Gly Lys Arg Lys Arg Ser Ser Ser Glu Asp Ala Glu 
    290                 295                 300                 


Ser Leu Ala Pro Arg Ser Lys Val Lys Lys Ile Ile Gln Lys Asp Ile 
305                 310                 315                 320 


Ile Lys Glu Ala Ser Glu Ala Ser Lys Glu Asn Arg Asp Ile Glu Ile 
                325                 330                 335     


Ser Thr Glu Glu Glu Lys Asp Thr Gly Asp Leu Lys Asp Ser Ser Leu 
            340                 345                 350         


Leu Lys Thr Lys Arg Lys His Lys Lys Lys His Lys Glu Arg His Lys 
        355                 360                 365             


Met Gly Glu Glu Val Ile Pro Leu Arg Val Leu Ser Lys Ser Glu Trp 
    370                 375                 380                 


Met Asp Leu Lys Lys Glu Tyr Leu Ala Leu Gln Lys Ala Ser Met Ala 
385                 390                 395                 400 


Ser Leu Lys Lys Thr Ile Ser Gln Ile Lys Ser Glu Ser Glu Met Glu 
                405                 410                 415     


Thr Asp Ser Gly Val Pro Gln Asn Thr Gly Met Lys Asn Glu Lys Thr 
            420                 425                 430         


Ala Asn Arg Glu Glu Cys Arg Thr Gln Glu Lys Val Asn Ala Thr Gly 
        435                 440                 445             


Pro Gln Phe Val Ser Gly Val Ile Val Lys Ile Ile Ser Thr Glu Pro 
    450                 455                 460                 


Leu Pro Gly Arg Lys Gln Val Arg Asp Thr Leu Ala Ala Ile Ser Glu 
465                 470                 475                 480 


Val Leu Tyr Val Asp Leu Leu Glu Gly Asp Thr Glu Cys His Ala Arg 
                485                 490                 495     


Phe Lys Thr Pro Glu Asp Ala Gln Ala Val Ile Asn Ala Tyr Thr Glu 
            500                 505                 510         


Ile Asn Lys Lys His Cys Trp Lys Leu Glu Ile Leu Ser Gly Asp His 
        515                 520                 525             


Glu Gln Gly Ile Gly Arg Arg Phe Trp Leu Ile Asp Arg Gln Asn Leu 
    530                 535                 540                 


Ile Ser Leu Gly Lys Arg Lys Glu Ala Leu Lys Ser 
545                 550                 555     


<210>  111
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Gly Glu Glu Val Ile Pro Leu Arg Val Leu Ser Lys Ser Glu Trp 
1               5                   10                  15      


Met Asp Leu Lys Lys Glu Tyr Leu Ala Leu Gln Lys Ala Ser Met Ala 
            20                  25                  30          


Ser Leu Lys Lys Thr Ile Ser Gln Ile Lys Ser Glu Ser Glu Met Glu 
        35                  40                  45              


Thr Asp Ser Gly Val Pro Gln Asn Thr Gly Met Lys Asn Glu Lys Thr 
    50                  55                  60                  


Ala Asn Arg Glu Glu Cys Arg Thr Gln Glu Lys Val Asn Ala Thr Gly 
65                  70                  75                  80  


Pro Gln Phe Val Ser Gly Val Ile Val Lys Ile Ile Ser Thr Glu Pro 
                85                  90                  95      


Leu Pro Gly Arg Lys Gln Val Arg Asp Thr Leu Ala Ala Ile Ser Glu 
            100                 105                 110         


Val Leu Tyr Val Asp Leu Leu Glu Gly Asp Thr Glu Cys His Ala Arg 
        115                 120                 125             


Phe Lys Thr Pro Glu Asp Ala Gln Ala Val Ile Asn Ala Tyr Thr Glu 
    130                 135                 140                 


Ile Asn Lys Glu His Cys Trp Lys Leu Glu Ile Leu Ser Gly Asp His 
145                 150                 155                 160 


Glu Gln Arg Tyr Trp Gln Lys Ile Leu Val Asp Arg Gln Ala Lys Leu 
                165                 170                 175     


Asn Gln Pro Arg Glu Lys Lys Arg Gly Thr Glu Lys Leu Ile Thr Lys 
            180                 185                 190         


Ala Glu Lys Ile Arg Leu Ala Lys Thr Gln Gln Ala Ser Lys His Ile 
        195                 200                 205             


Arg Phe Ser Glu Tyr Asp 
    210                 


<210>  112
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Asn Pro Thr Glu Thr Lys Ala Ile Pro Val Ser Gln Gln Met Glu 
1               5                   10                  15      


Gly Pro His Leu Pro Asn Lys Lys Lys His Lys Lys Gln Ala Val Lys 
            20                  25                  30          


Thr Glu Pro Glu Lys Lys Ser Gln Ser Thr Lys Leu Ser Val Val His 
        35                  40                  45              


Glu Lys Lys Ser Gln Glu Gly Lys Pro Lys Glu His Thr Glu Pro Lys 
    50                  55                  60                  


Ser Leu Pro Lys Gln Ala Ser Asp Thr Gly Ser Asn Asp Ala His Asn 
65                  70                  75                  80  


Lys Lys Ala Val Ser Arg Ser Ala Glu Gln Gln Pro Ser Glu Lys Ser 
                85                  90                  95      


Thr Glu Pro Lys Thr Lys Pro Gln Asp Met Ile Ser Ala Gly Gly Glu 
            100                 105                 110         


Ser Val Ala Gly Ile Thr Ala Ile Ser Gly Lys Pro Gly Asp Lys Lys 
        115                 120                 125             


Lys Glu Lys Lys Ser Leu Thr Pro Ala Val Pro Val Glu Ser Lys Pro 
    130                 135                 140                 


Asp Lys Pro Ser Gly Lys Ser Gly Met Asp Ala Ala Leu Asp Asp Leu 
145                 150                 155                 160 


Ile Asp Thr Leu Gly Gly Pro Glu Glu Thr Glu Glu Glu Asn Thr Thr 
                165                 170                 175     


Tyr Thr Gly Pro Glu Val Ser Asp Pro Met Ser Ser Thr Tyr Ile Glu 
            180                 185                 190         


Glu Leu Gly Lys Arg Glu Val Thr Ile Pro Pro Lys Tyr Arg Glu Leu 
        195                 200                 205             


Leu Ala Lys Lys Glu Gly Ile Thr Gly Pro Pro Ala Asp Ser Ser Lys 
    210                 215                 220                 


Pro Ile Gly Pro Asp Asp Ala Ile Asp Ala Leu Ser Ser Asp Phe Thr 
225                 230                 235                 240 


Cys Gly Ser Pro Thr Ala Ala Gly Lys Lys Thr Glu Lys Glu Glu Ser 
                245                 250                 255     


Thr Glu Val Leu Lys Ala Gln Ser Ala Gly Thr Val Arg Ser Ala Ala 
            260                 265                 270         


Pro Pro Gln Glu Lys Lys Arg Lys Val Glu Lys Asp Thr Met Ser Asp 
        275                 280                 285             


Gln Ala Leu Glu Ala Leu Ser Ala Ser Leu Gly Thr Arg Gln Ala Glu 
    290                 295                 300                 


Pro Glu Leu Asp Leu Arg Ser Ile Lys Glu Val Asp Glu Ala Lys Ala 
305                 310                 315                 320 


Lys Glu Glu Lys Leu Glu Lys Cys Gly Glu Asp Asp Glu Thr Ile Pro 
                325                 330                 335     


Ser Glu Tyr Arg Leu Lys Pro Ala Thr Asp Lys Asp Gly Lys Pro Leu 
            340                 345                 350         


Leu Pro Glu Pro Glu Glu Lys Pro Lys Pro Arg Ser Glu Ser Glu Leu 
        355                 360                 365             


Ile Asp Glu Leu Ser Glu Asp Phe Asp Arg Ser Glu Cys Lys Glu Lys 
    370                 375                 380                 


Pro Ser Lys Pro Thr Glu Lys Thr Glu Glu Ser Lys Ala Ala Ala Pro 
385                 390                 395                 400 


Ala Pro Val Ser Glu Ala Val Ser Arg Thr Ser Met Cys Ser Ile Gln 
                405                 410                 415     


Ser Ala Pro Pro Glu Pro Ala Thr Leu Lys Gly Thr Val Pro Asp Asp 
            420                 425                 430         


Ala Val Glu Ala Leu Ala Asp Ser Leu Gly Lys Lys Glu Ala Asp Pro 
        435                 440                 445             


Glu Asp Gly Lys Pro Val Met Asp Lys Val Lys Glu Lys Ala Lys Glu 
    450                 455                 460                 


Glu Asp Arg Glu Lys Leu Gly Glu Lys Glu Glu Thr Ile Pro Pro Asp 
465                 470                 475                 480 


Tyr Arg Leu Glu Glu Val Lys Asp Lys Asp Gly Lys Pro Leu Leu Pro 
                485                 490                 495     


Lys Glu Ser Lys Glu Gln Leu Pro Pro Met Ser Glu Asp Phe Leu Leu 
            500                 505                 510         


Asp Ala Leu Ser Glu Asp Phe Ser Gly Pro Gln Asn Ala Ser Ser Leu 
        515                 520                 525             


Lys Phe Glu Asp Ala Lys Leu Ala Ala Ala Ile Ser Glu Val Val Ser 
    530                 535                 540                 


Gln Thr Pro Ala Ser Thr Thr Gln Ala Gly Ala Pro Pro Arg Asp Thr 
545                 550                 555                 560 


Ser Gln Ser Asp Lys Asp Leu Asp Asp Ala Leu Asp Lys Leu Ser Asp 
                565                 570                 575     


Ser Leu Gly Gln Arg Gln Pro Asp Pro Asp Glu Asn Lys Pro Met Gly 
            580                 585                 590         


Asp Lys Val Lys Glu Lys Ala Lys Ala Glu His Arg Asp Lys Leu Gly 
        595                 600                 605             


Glu Arg Asp Asp Thr Ile Pro Pro Glu Tyr Arg His Leu Leu Asp Asp 
    610                 615                 620                 


Asn Gly Gln Asp Lys Pro Val Lys Pro Pro Thr Lys Lys Ser Glu Asp 
625                 630                 635                 640 


Ser Lys Lys Pro Ala Asp Asp Gln Asp Pro Ile Asp Ala Leu Ser Gly 
                645                 650                 655     


Asp Leu Asp Ser Cys Pro Ser Thr Thr Glu Thr Ser Gln Asn Thr Ala 
            660                 665                 670         


Lys Asp Lys Cys Lys Lys Ala Ala Ser Ser Ser Lys Ala Pro Lys Asn 
        675                 680                 685             


Gly Gly Lys Ala Lys Asp Ser Ala Lys Thr Thr Glu Glu Thr Ser Lys 
    690                 695                 700                 


Pro Lys Asp Asp 
705             


<210>  113
<211>  1688
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Thr Gln Ser Thr Val Pro Leu Asn Leu Ile Arg Val His Leu Met 
1               5                   10                  15      


Val Ala Val Glu Gly His Leu Phe Gln Lys Ser Phe Gln Ala Ser Pro 
            20                  25                  30          


Asn Leu Ala Tyr Thr Phe Ile Trp Asp Lys Thr Asp Ala Tyr Gly Gln 
        35                  40                  45              


Arg Val Tyr Gly Leu Ser Asp Ala Val Val Ser Val Gly Phe Glu Tyr 
    50                  55                  60                  


Glu Thr Cys Pro Ser Leu Ile Leu Trp Glu Lys Arg Thr Ala Leu Leu 
65                  70                  75                  80  


Gln Gly Phe Glu Leu Asp Pro Ser Asn Leu Gly Gly Trp Ser Leu Asp 
                85                  90                  95      


Lys His His Ile Leu Asn Val Lys Ser Gly Ile Leu His Lys Gly Thr 
            100                 105                 110         


Gly Glu Asn Gln Phe Leu Thr Gln Gln Pro Ala Ile Ile Thr Ser Ile 
        115                 120                 125             


Met Gly Asn Gly Arg Arg Arg Ser Ile Ser Cys Pro Ser Cys Asn Gly 
    130                 135                 140                 


Leu Ala Glu Gly Asn Lys Leu Leu Ala Pro Val Ala Leu Ala Val Gly 
145                 150                 155                 160 


Ile Asp Gly Ser Leu Tyr Val Gly Asp Phe Asn Tyr Ile Arg Arg Ile 
                165                 170                 175     


Phe Pro Ser Arg Asn Val Thr Ser Ile Leu Glu Leu Arg Asn Lys Glu 
            180                 185                 190         


Phe Lys His Ser Asn Asn Pro Ala His Lys Tyr Tyr Leu Ala Val Asp 
        195                 200                 205             


Pro Val Ser Gly Ser Leu Tyr Val Ser Asp Thr Asn Ser Arg Arg Ile 
    210                 215                 220                 


Tyr Arg Val Lys Ser Leu Ser Gly Thr Lys Asp Leu Ala Gly Asn Ser 
225                 230                 235                 240 


Glu Val Val Ala Gly Thr Gly Glu Gln Cys Leu Pro Phe Asp Glu Ala 
                245                 250                 255     


Arg Cys Gly Asp Gly Gly Lys Ala Ile Asp Ala Thr Leu Met Ser Pro 
            260                 265                 270         


Arg Gly Ile Ala Val Asp Lys Asn Gly Leu Met Tyr Phe Val Asp Ala 
        275                 280                 285             


Thr Met Ile Arg Lys Val Asp Gln Asn Gly Ile Ile Ser Thr Leu Leu 
    290                 295                 300                 


Gly Ser Asn Asp Leu Thr Ala Val Arg Pro Leu Ser Cys Asp Ser Ser 
305                 310                 315                 320 


Met Asp Val Ala Gln Val Arg Leu Glu Trp Pro Thr Asp Leu Ala Val 
                325                 330                 335     


Asn Pro Met Asp Asn Ser Leu Tyr Val Leu Glu Asn Asn Val Ile Leu 
            340                 345                 350         


Arg Ile Thr Glu Asn His Gln Val Ser Ile Ile Ala Gly Arg Pro Met 
        355                 360                 365             


His Cys Gln Val Pro Gly Ile Asp Tyr Ser Leu Ser Lys Leu Ala Ile 
    370                 375                 380                 


His Ser Ala Leu Glu Ser Ala Ser Ala Ile Ala Ile Ser His Thr Gly 
385                 390                 395                 400 


Val Leu Tyr Ile Thr Glu Thr Asp Glu Lys Lys Ile Asn Arg Leu Arg 
                405                 410                 415     


Gln Val Thr Thr Asn Gly Glu Ile Cys Leu Leu Ala Gly Ala Ala Ser 
            420                 425                 430         


Asp Cys Asp Cys Lys Asn Asp Val Asn Cys Asn Cys Tyr Ser Gly Asp 
        435                 440                 445             


Asp Ala Tyr Ala Thr Asp Ala Ile Leu Asn Ser Pro Ser Ser Leu Ala 
    450                 455                 460                 


Val Ala Pro Asp Gly Thr Ile Tyr Ile Ala Asp Leu Gly Asn Ile Arg 
465                 470                 475                 480 


Ile Arg Ala Val Ser Lys Asn Lys Pro Val Leu Asn Ala Phe Asn Gln 
                485                 490                 495     


Tyr Glu Ala Ala Ser Pro Gly Glu Gln Glu Leu Tyr Val Phe Asn Ala 
            500                 505                 510         


Asp Gly Ile His Gln Tyr Thr Val Ser Leu Val Thr Gly Glu Tyr Leu 
        515                 520                 525             


Tyr Asn Phe Thr Tyr Ser Thr Asp Asn Asp Val Thr Glu Leu Ile Asp 
    530                 535                 540                 


Asn Asn Gly Asn Ser Leu Lys Ile Arg Arg Asp Ser Ser Gly Met Pro 
545                 550                 555                 560 


Arg His Leu Leu Met Pro Asp Asn Gln Ile Ile Thr Leu Thr Val Gly 
                565                 570                 575     


Thr Asn Gly Gly Leu Lys Val Val Ser Thr Gln Asn Leu Glu Leu Gly 
            580                 585                 590         


Leu Met Thr Tyr Asp Gly Asn Thr Gly Leu Leu Ala Thr Lys Ser Asp 
        595                 600                 605             


Glu Thr Gly Trp Thr Thr Phe Tyr Asp Tyr Asp His Glu Gly Arg Leu 
    610                 615                 620                 


Thr Asn Val Thr Arg Pro Thr Gly Val Val Thr Ser Leu His Arg Glu 
625                 630                 635                 640 


Met Glu Lys Ser Ile Thr Ile Asp Ile Glu Asn Ser Asn Arg Asp Asp 
                645                 650                 655     


Asp Val Thr Val Ile Thr Asn Leu Ser Ser Val Glu Ala Ser Tyr Thr 
            660                 665                 670         


Val Val Gln Asp Gln Val Arg Asn Ser Tyr Gln Leu Cys Asn Asn Gly 
        675                 680                 685             


Thr Leu Arg Val Met Tyr Ala Asn Gly Met Gly Ile Ser Phe His Ser 
    690                 695                 700                 


Glu Pro His Val Leu Ala Gly Thr Ile Thr Pro Thr Ile Gly Arg Cys 
705                 710                 715                 720 


Asn Ile Ser Leu Pro Met Glu Asn Gly Leu Asn Ser Ile Glu Trp Arg 
                725                 730                 735     


Leu Arg Lys Glu Gln Ile Lys Gly Lys Val Thr Ile Phe Gly Arg Lys 
            740                 745                 750         


Leu Arg Val His Gly Arg Asn Leu Leu Ser Ile Asp Tyr Asp Arg Asn 
        755                 760                 765             


Ile Arg Thr Glu Lys Ile Tyr Asp Asp His Arg Lys Phe Thr Leu Arg 
    770                 775                 780                 


Ile Ile Tyr Asp Gln Val Gly Arg Pro Phe Leu Trp Leu Pro Ser Ser 
785                 790                 795                 800 


Gly Leu Ala Ala Val Asn Val Ser Tyr Phe Phe Asn Gly Arg Leu Ala 
                805                 810                 815     


Gly Leu Gln Arg Gly Ala Met Ser Glu Arg Thr Asp Ile Asp Lys Gln 
            820                 825                 830         


Gly Arg Ile Val Ser Arg Met Phe Ala Asp Gly Lys Val Trp Ser Tyr 
        835                 840                 845             


Ser Tyr Leu Asp Lys Ser Met Val Leu Leu Leu Gln Ser Gln Arg Gln 
    850                 855                 860                 


Tyr Ile Phe Glu Tyr Asp Ser Ser Asp Arg Leu Leu Ala Val Thr Met 
865                 870                 875                 880 


Pro Ser Val Ala Arg His Ser Met Ser Thr His Thr Ser Ile Gly Tyr 
                885                 890                 895     


Ile Arg Asn Ile Tyr Asn Pro Pro Glu Ser Asn Ala Ser Val Ile Phe 
            900                 905                 910         


Asp Tyr Ser Asp Asp Gly Arg Ile Leu Lys Thr Ser Phe Leu Gly Thr 
        915                 920                 925             


Gly Arg Gln Val Phe Tyr Lys Tyr Gly Lys Leu Ser Lys Leu Ser Glu 
    930                 935                 940                 


Ile Val Tyr Asp Ser Thr Ala Val Thr Phe Gly Tyr Asp Glu Thr Thr 
945                 950                 955                 960 


Gly Val Leu Lys Met Val Asn Leu Gln Ser Gly Gly Phe Ser Cys Thr 
                965                 970                 975     


Ile Arg Tyr Arg Lys Ile Gly Pro Leu Val Asp Lys Gln Ile Tyr Arg 
            980                 985                 990         


Phe Ser Glu Glu Gly Met Val Asn  Ala Arg Phe Asp Tyr  Thr Tyr His 
        995                 1000                 1005             


Asp Asn  Ser Phe Arg Ile Ala  Ser Ile Lys Pro Val  Ile Ser Glu 
    1010                 1015                 1020             


Thr Pro  Leu Pro Val Asp Leu  Tyr Arg Tyr Asp Glu  Ile Ser Gly 
    1025                 1030                 1035             


Lys Val  Glu His Phe Gly Lys  Phe Gly Val Ile Tyr  Tyr Asp Ile 
    1040                 1045                 1050             


Asn Gln  Ile Ile Thr Thr Ala  Val Met Thr Leu Ser  Lys His Phe 
    1055                 1060                 1065             


Asp Thr  His Gly Arg Ile Lys  Glu Val Gln Tyr Glu  Met Phe Arg 
    1070                 1075                 1080             


Ser Leu  Met Tyr Trp Met Thr  Val Gln Tyr Asp Ser  Met Gly Arg 
    1085                 1090                 1095             


Val Ile  Lys Arg Glu Leu Lys  Leu Gly Pro Tyr Ala  Asn Thr Thr 
    1100                 1105                 1110             


Lys Tyr  Thr Tyr Asp Tyr Asp  Gly Asp Gly Gln Leu  Gln Ser Val 
    1115                 1120                 1125             


Ala Val  Asn Asp Arg Pro Thr  Trp Arg Tyr Ser Tyr  Asp Leu Asn 
    1130                 1135                 1140             


Gly Asn  Leu His Leu Leu Asn  Pro Gly Asn Ser Val  Arg Leu Met 
    1145                 1150                 1155             


Pro Leu  Arg Tyr Asp Leu Arg  Asp Arg Ile Thr Arg  Leu Gly Asp 
    1160                 1165                 1170             


Val Gln  Tyr Lys Ile Asp Asp  Asp Gly Tyr Leu Cys  Gln Arg Gly 
    1175                 1180                 1185             


Ser Asp  Ile Phe Glu Tyr Asn  Ser Lys Gly Leu Leu  Thr Arg Ala 
    1190                 1195                 1200             


Tyr Asn  Lys Ala Ser Gly Trp  Ser Val Gln Tyr Arg  Tyr Asp Gly 
    1205                 1210                 1215             


Val Gly  Arg Arg Ala Ser Tyr  Lys Thr Asn Leu Gly  His His Leu 
    1220                 1225                 1230             


Gln Tyr  Phe Tyr Ser Asp Leu  His Asn Pro Thr Arg  Ile Thr His 
    1235                 1240                 1245             


Val Tyr  Asn His Ser Asn Ser  Glu Ile Thr Ser Leu  Tyr Tyr Asp 
    1250                 1255                 1260             


Leu Gln  Gly His Leu Phe Ala  Met Glu Ser Ser Ser  Gly Glu Glu 
    1265                 1270                 1275             


Tyr Tyr  Val Ala Ser Asp Asn  Thr Gly Thr Pro Leu  Ala Val Phe 
    1280                 1285                 1290             


Ser Ile  Asn Gly Leu Met Ile  Lys Gln Leu Gln Tyr  Thr Ala Tyr 
    1295                 1300                 1305             


Gly Glu  Ile Tyr Tyr Asp Ser  Asn Pro Asp Phe Gln  Met Val Ile 
    1310                 1315                 1320             


Gly Phe  His Gly Gly Leu Tyr  Asp Pro Leu Thr Lys  Leu Val His 
    1325                 1330                 1335             


Phe Thr  Gln Arg Asp Tyr Asp  Val Leu Ala Gly Arg  Trp Thr Ser 
    1340                 1345                 1350             


Pro Asp  Tyr Thr Met Trp Lys  Asn Val Gly Lys Glu  Pro Ala Pro 
    1355                 1360                 1365             


Phe Asn  Leu Tyr Met Phe Lys  Ser Asn Asn Pro Leu  Ser Ser Glu 
    1370                 1375                 1380             


Leu Asp  Leu Lys Asn Tyr Val  Thr Asp Val Lys Ser  Trp Leu Val 
    1385                 1390                 1395             


Met Phe  Gly Phe Gln Leu Ser  Asn Ile Ile Pro Gly  Phe Pro Arg 
    1400                 1405                 1410             


Ala Lys  Met Tyr Phe Val Pro  Pro Pro Tyr Glu Leu  Ser Glu Ser 
    1415                 1420                 1425             


Gln Ala  Ser Glu Asn Gly Gln  Leu Ile Thr Gly Val  Gln Gln Thr 
    1430                 1435                 1440             


Thr Glu  Arg His Asn Gln Ala  Phe Met Ala Leu Glu  Gly Gln Val 
    1445                 1450                 1455             


Ile Thr  Lys Lys Leu His Ala  Ser Ile Arg Glu Lys  Ala Gly His 
    1460                 1465                 1470             


Trp Phe  Ala Thr Thr Thr Pro  Ile Ile Gly Lys Gly  Ile Met Phe 
    1475                 1480                 1485             


Ala Ile  Lys Glu Gly Arg Val  Thr Thr Gly Val Ser  Ser Ile Ala 
    1490                 1495                 1500             


Ser Glu  Asp Ser Arg Lys Val  Ala Ser Val Leu Asn  Asn Ala Tyr 
    1505                 1510                 1515             


Tyr Leu  Asp Lys Met His Tyr  Ser Ile Glu Gly Lys  Asp Thr His 
    1520                 1525                 1530             


Tyr Phe  Val Lys Ile Gly Ser  Ala Asp Gly Asp Leu  Val Thr Leu 
    1535                 1540                 1545             


Gly Thr  Thr Ile Gly Arg Lys  Val Leu Glu Ser Gly  Val Asn Val 
    1550                 1555                 1560             


Thr Val  Ser Gln Pro Thr Leu  Leu Val Asn Gly Arg  Thr Arg Arg 
    1565                 1570                 1575             


Phe Thr  Asn Ile Glu Phe Gln  Tyr Ser Thr Leu Leu  Leu Ser Ile 
    1580                 1585                 1590             


Arg Tyr  Gly Leu Thr Pro Asp  Thr Leu Asp Glu Glu  Lys Ala Arg 
    1595                 1600                 1605             


Val Leu  Asp Gln Ala Arg Gln  Arg Ala Leu Gly Thr  Ala Trp Ala 
    1610                 1615                 1620             


Lys Glu  Gln Gln Lys Ala Arg  Asp Gly Arg Glu Gly  Ser Arg Leu 
    1625                 1630                 1635             


Trp Thr  Glu Gly Glu Lys Gln  Gln Leu Leu Ser Thr  Gly Arg Val 
    1640                 1645                 1650             


Gln Gly  Tyr Glu Gly Tyr Tyr  Val Leu Pro Val Glu  Gln Tyr Pro 
    1655                 1660                 1665             


Glu Leu  Ala Asp Ser Ser Ser  Asn Ile Gln Phe Leu  Arg Gln Asn 
    1670                 1675                 1680             


Glu Met  Gly Lys Arg 
    1685             


<210>  114
<211>  1871
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Ala Asn Leu Glu Glu Ser Phe Pro Arg Gly Gly Thr Arg Lys Ile 
1               5                   10                  15      


His Lys Pro Glu Lys Ala Phe Gln Gln Ser Val Glu Gln Asp Asn Leu 
            20                  25                  30          


Phe Asp Ile Ser Thr Glu Glu Gly Ser Thr Lys Arg Lys Lys Ser Gln 
        35                  40                  45              


Lys Gly Pro Ala Lys Thr Lys Lys Leu Lys Ile Glu Lys Arg Glu Ser 
    50                  55                  60                  


Ser Lys Ser Ala Arg Glu Lys Phe Glu Ile Leu Ser Val Glu Ser Leu 
65                  70                  75                  80  


Cys Glu Gly Met Arg Ile Leu Gly Cys Val Lys Glu Val Asn Glu Leu 
                85                  90                  95      


Glu Leu Val Ile Ser Leu Pro Asn Gly Leu Gln Gly Phe Val Gln Val 
            100                 105                 110         


Thr Glu Ile Cys Asp Ala Tyr Thr Lys Lys Leu Asn Glu Gln Val Thr 
        115                 120                 125             


Gln Glu Gln Pro Leu Lys Asp Leu Leu His Leu Pro Glu Leu Phe Ser 
    130                 135                 140                 


Pro Gly Met Leu Val Arg Cys Val Val Ser Ser Leu Gly Ile Thr Asp 
145                 150                 155                 160 


Arg Gly Lys Lys Ser Val Lys Leu Ser Leu Asn Pro Lys Asn Val Asn 
                165                 170                 175     


Arg Val Leu Ser Ala Glu Ala Leu Lys Pro Gly Met Leu Leu Thr Gly 
            180                 185                 190         


Thr Val Ser Ser Leu Glu Asp His Gly Tyr Leu Val Asp Ile Gly Val 
        195                 200                 205             


Asp Gly Thr Arg Ala Phe Leu Pro Leu Leu Lys Ala Gln Glu Tyr Ile 
    210                 215                 220                 


Arg Gln Lys Asn Lys Gly Ala Lys Leu Lys Val Gly Gln Tyr Leu Asn 
225                 230                 235                 240 


Cys Ile Val Glu Lys Val Lys Gly Asn Gly Gly Val Val Ser Leu Ser 
                245                 250                 255     


Val Gly His Ser Glu Val Ser Thr Ala Ile Ala Thr Glu Gln Gln Ser 
            260                 265                 270         


Trp Asn Leu Asn Asn Leu Leu Pro Gly Leu Val Val Lys Ala Gln Val 
        275                 280                 285             


Gln Lys Val Thr Pro Phe Gly Leu Thr Leu Asn Phe Leu Thr Phe Phe 
    290                 295                 300                 


Thr Gly Val Val Asp Phe Met His Leu Asp Pro Lys Lys Ala Gly Thr 
305                 310                 315                 320 


Tyr Phe Ser Asn Gln Ala Val Arg Ala Cys Ile Leu Cys Val His Pro 
                325                 330                 335     


Arg Thr Arg Val Val His Leu Ser Leu Arg Pro Ile Phe Leu Gln Pro 
            340                 345                 350         


Gly Arg Pro Leu Thr Arg Leu Ser Cys Gln Asn Leu Gly Ala Val Leu 
        355                 360                 365             


Asp Asp Val Pro Val Gln Gly Phe Phe Lys Lys Ala Gly Ala Thr Phe 
    370                 375                 380                 


Arg Leu Lys Asp Gly Val Leu Ala Tyr Ala Arg Leu Ser His Leu Ser 
385                 390                 395                 400 


Asp Ser Lys Asn Val Phe Asn Pro Glu Ala Phe Lys Pro Gly Asn Thr 
                405                 410                 415     


His Lys Cys Arg Ile Ile Asp Tyr Ser Gln Met Asp Glu Leu Ala Leu 
            420                 425                 430         


Leu Ser Leu Arg Thr Ser Ile Ile Glu Ala Gln Tyr Leu Arg Tyr His 
        435                 440                 445             


Asp Ile Glu Pro Gly Ala Val Val Lys Gly Thr Val Leu Thr Ile Lys 
    450                 455                 460                 


Ser Tyr Gly Met Leu Val Lys Val Gly Glu Gln Met Arg Gly Leu Val 
465                 470                 475                 480 


Pro Pro Met His Leu Ala Asp Ile Leu Met Lys Asn Pro Glu Lys Lys 
                485                 490                 495     


Tyr His Ile Gly Asp Glu Val Lys Cys Arg Val Leu Leu Cys Asp Pro 
            500                 505                 510         


Glu Ala Lys Lys Leu Met Met Thr Leu Lys Lys Thr Leu Ile Glu Ser 
        515                 520                 525             


Lys Leu Pro Val Ile Thr Cys Tyr Ala Asp Ala Lys Pro Gly Leu Gln 
    530                 535                 540                 


Thr His Gly Phe Ile Ile Arg Val Lys Asp Tyr Gly Cys Ile Val Lys 
545                 550                 555                 560 


Phe Tyr Asn Asn Val Gln Gly Leu Val Pro Lys His Glu Leu Ser Thr 
                565                 570                 575     


Glu Tyr Ile Pro Asp Pro Glu Arg Val Phe Tyr Thr Gly Gln Val Val 
            580                 585                 590         


Lys Val Val Val Leu Asn Cys Glu Pro Ser Lys Glu Arg Met Leu Leu 
        595                 600                 605             


Ser Phe Lys Leu Ser Ser Asp Pro Glu Pro Lys Lys Glu Pro Ala Gly 
    610                 615                 620                 


His Ser Gln Lys Lys Gly Lys Ala Ile Asn Ile Gly Gln Leu Val Asp 
625                 630                 635                 640 


Val Lys Val Leu Glu Lys Thr Lys Asp Gly Leu Glu Val Ala Val Leu 
                645                 650                 655     


Pro His Asn Ile Arg Ala Phe Leu Pro Thr Ser His Leu Ser Asp His 
            660                 665                 670         


Val Ala Asn Gly Pro Leu Leu His His Trp Leu Gln Ala Gly Asp Ile 
        675                 680                 685             


Leu His Arg Val Leu Cys Leu Ser Gln Ser Glu Gly Arg Val Leu Leu 
    690                 695                 700                 


Cys Arg Lys Pro Ala Leu Val Ser Thr Val Glu Gly Gly Gln Asp Pro 
705                 710                 715                 720 


Lys Asn Phe Ser Glu Ile His Pro Gly Met Leu Leu Ile Gly Phe Val 
                725                 730                 735     


Lys Ser Ile Lys Asp Tyr Gly Val Phe Ile Gln Phe Pro Ser Gly Leu 
            740                 745                 750         


Ser Gly Leu Ala Pro Lys Ala Ile Met Ser Asp Lys Phe Val Thr Ser 
        755                 760                 765             


Thr Ser Asp His Phe Val Glu Gly Gln Thr Val Ala Ala Lys Val Thr 
    770                 775                 780                 


Asn Val Asp Glu Glu Lys Gln Arg Met Leu Leu Ser Leu Arg Leu Ser 
785                 790                 795                 800 


Asp Cys Gly Leu Gly Asp Leu Ala Ile Thr Ser Leu Leu Leu Leu Asn 
                805                 810                 815     


Gln Cys Leu Glu Glu Leu Gln Gly Val Arg Ser Leu Met Ser Asn Arg 
            820                 825                 830         


Asp Ser Val Leu Ile Gln Thr Leu Ala Glu Met Thr Pro Gly Met Phe 
        835                 840                 845             


Leu Asp Leu Val Val Gln Glu Val Leu Glu Asp Gly Ser Val Val Phe 
    850                 855                 860                 


Ser Gly Gly Pro Val Pro Asp Leu Val Leu Lys Ala Ser Arg Tyr His 
865                 870                 875                 880 


Arg Ala Gly Gln Glu Val Glu Ser Gly Gln Lys Lys Lys Val Val Ile 
                885                 890                 895     


Leu Asn Val Asp Leu Leu Lys Leu Glu Val His Val Ser Leu His Gln 
            900                 905                 910         


Asp Leu Val Asn Arg Lys Ala Arg Lys Leu Arg Lys Gly Ser Glu His 
        915                 920                 925             


Gln Ala Ile Val Gln His Leu Glu Lys Ser Phe Ala Ile Ala Ser Leu 
    930                 935                 940                 


Val Glu Thr Gly His Leu Ala Ala Phe Ser Leu Thr Ser His Leu Asn 
945                 950                 955                 960 


Asp Thr Phe Arg Phe Asp Ser Glu Lys Leu Gln Val Gly Gln Gly Val 
                965                 970                 975     


Ser Leu Thr Leu Lys Thr Thr Glu Pro Gly Val Thr Gly Leu Leu Leu 
            980                 985                 990         


Ala Val Glu Gly Pro Ala Ala Lys  Arg Thr Met Arg Pro  Thr Gln Lys 
        995                 1000                 1005             


Asp Ser  Glu Thr Val Asp Glu  Asp Glu Glu Val Asp  Pro Ala Leu 
    1010                 1015                 1020             


Thr Val  Gly Thr Ile Lys Lys  His Thr Leu Ser Ile  Gly Asp Met 
    1025                 1030                 1035             


Val Thr  Gly Thr Val Lys Ser  Ile Lys Pro Thr His  Val Val Val 
    1040                 1045                 1050             


Thr Leu  Glu Asp Gly Ile Ile  Gly Cys Ile His Ala  Ser His Ile 
    1055                 1060                 1065             


Leu Asp  Asp Val Pro Glu Gly  Thr Ser Pro Thr Thr  Lys Leu Lys 
    1070                 1075                 1080             


Val Gly  Lys Thr Val Thr Ala  Arg Val Ile Gly Gly  Arg Asp Met 
    1085                 1090                 1095             


Lys Thr  Phe Lys Tyr Leu Pro  Ile Ser His Pro Arg  Phe Val Arg 
    1100                 1105                 1110             


Thr Ile  Pro Glu Leu Ser Val  Arg Pro Ser Glu Leu  Glu Asp Gly 
    1115                 1120                 1125             


His Thr  Ala Leu Asn Thr His  Ser Val Ser Pro Met  Glu Lys Ile 
    1130                 1135                 1140             


Lys Gln  Tyr Gln Ala Gly Gln  Thr Val Thr Cys Phe  Leu Lys Lys 
    1145                 1150                 1155             


Tyr Asn  Val Val Lys Lys Trp  Leu Glu Val Glu Ile  Ala Pro Asp 
    1160                 1165                 1170             


Ile Arg  Gly Arg Ile Pro Leu  Leu Leu Thr Ser Leu  Ser Phe Lys 
    1175                 1180                 1185             


Val Leu  Lys His Pro Asp Lys  Lys Phe Arg Val Gly  Gln Ala Leu 
    1190                 1195                 1200             


Arg Ala  Thr Val Val Gly Pro  Asp Ser Ser Lys Thr  Leu Leu Cys 
    1205                 1210                 1215             


Leu Ser  Leu Thr Gly Pro His  Lys Leu Glu Glu Gly  Glu Val Ala 
    1220                 1225                 1230             


Met Gly  Arg Val Val Lys Val  Thr Pro Asn Glu Gly  Leu Thr Val 
    1235                 1240                 1245             


Ser Phe  Pro Phe Gly Lys Ile  Gly Thr Val Ser Ile  Phe His Met 
    1250                 1255                 1260             


Ser Asp  Ser Tyr Ser Glu Thr  Pro Leu Glu Asp Phe  Val Pro Gln 
    1265                 1270                 1275             


Lys Val  Val Arg Cys Tyr Ile  Leu Ser Thr Ala Asp  Asn Val Leu 
    1280                 1285                 1290             


Thr Leu  Ser Leu Arg Ser Ser  Arg Thr Asn Pro Glu  Thr Lys Ser 
    1295                 1300                 1305             


Lys Val  Glu Asp Pro Glu Ile  Asn Ser Ile Gln Asp  Ile Lys Glu 
    1310                 1315                 1320             


Gly Gln  Leu Leu Arg Gly Tyr  Val Gly Ser Ile Gln  Pro His Gly 
    1325                 1330                 1335             


Val Phe  Phe Arg Leu Gly Pro  Ser Val Val Gly Leu  Ala Arg Tyr 
    1340                 1345                 1350             


Ser His  Val Ser Gln His Ser  Pro Ser Lys Lys Ala  Leu Tyr Asn 
    1355                 1360                 1365             


Lys His  Leu Pro Glu Gly Lys  Leu Leu Thr Ala Arg  Val Leu Arg 
    1370                 1375                 1380             


Leu Asn  His Gln Lys Asn Leu  Val Glu Leu Ser Phe  Leu Pro Gly 
    1385                 1390                 1395             


Asp Thr  Gly Lys Pro Asp Val  Leu Ser Ala Ser Leu  Glu Gly Gln 
    1400                 1405                 1410             


Leu Thr  Lys Gln Glu Glu Arg  Lys Thr Glu Ala Glu  Glu Arg Asp 
    1415                 1420                 1425             


Gln Lys  Gly Glu Lys Lys Asn  Gln Lys Arg Asn Glu  Lys Lys Asn 
    1430                 1435                 1440             


Gln Lys  Gly Gln Glu Glu Val  Glu Met Pro Ser Lys  Glu Lys Gln 
    1445                 1450                 1455             


Gln Pro  Gln Lys Pro Gln Ala  Gln Lys Arg Gly Gly  Arg Glu Cys 
    1460                 1465                 1470             


Arg Glu  Ser Gly Ser Glu Gln  Glu Arg Val Ser Lys  Lys Pro Lys 
    1475                 1480                 1485             


Lys Ala  Gly Leu Ser Glu Glu  Asp Asp Ser Leu Val  Asp Val Tyr 
    1490                 1495                 1500             


Tyr Arg  Glu Gly Lys Glu Glu  Ala Glu Glu Thr Asn  Val Leu Pro 
    1505                 1510                 1515             


Lys Glu  Lys Gln Thr Lys Pro  Ala Glu Ala Pro Arg  Leu Gln Leu 
    1520                 1525                 1530             


Ser Ser  Gly Phe Ala Trp Asn  Val Gly Leu Asp Ser  Leu Thr Pro 
    1535                 1540                 1545             


Ala Leu  Pro Pro Leu Ala Glu  Ser Ser Asp Ser Glu  Glu Asp Glu 
    1550                 1555                 1560             


Lys Pro  His Gln Ala Thr Ile  Lys Lys Ser Lys Lys  Glu Arg Glu 
    1565                 1570                 1575             


Leu Glu  Lys Gln Lys Ala Glu  Lys Glu Leu Ser Arg  Ile Glu Glu 
    1580                 1585                 1590             


Ala Leu  Met Asp Pro Gly Arg  Gln Pro Glu Ser Ala  Asp Asp Phe 
    1595                 1600                 1605             


Asp Arg  Leu Val Leu Ser Ser  Pro Asn Ser Ser Ile  Leu Trp Leu 
    1610                 1615                 1620             


Gln Tyr  Met Ala Phe His Leu  Gln Ala Thr Glu Ile  Glu Lys Ala 
    1625                 1630                 1635             


Arg Ala  Val Ala Glu Arg Ala  Leu Lys Thr Ile Ser  Phe Arg Glu 
    1640                 1645                 1650             


Glu Gln  Glu Lys Leu Asn Val  Trp Val Ala Leu Leu  Asn Leu Glu 
    1655                 1660                 1665             


Asn Met  Tyr Gly Ser Gln Glu  Ser Leu Thr Lys Val  Phe Glu Arg 
    1670                 1675                 1680             


Ala Val  Gln Tyr Asn Glu Pro  Leu Lys Val Phe Leu  His Leu Ala 
    1685                 1690                 1695             


Asp Ile  Tyr Ala Lys Ser Glu  Lys Phe Gln Glu Ala  Gly Glu Leu 
    1700                 1705                 1710             


Tyr Asn  Arg Met Leu Lys Arg  Phe Arg Gln Glu Lys  Ala Val Trp 
    1715                 1720                 1725             


Ile Lys  Tyr Gly Ala Phe Leu  Leu Arg Arg Ser Gln  Ala Ala Ala 
    1730                 1735                 1740             


Ser His  Arg Val Leu Gln Arg  Ala Leu Glu Cys Leu  Pro Ser Lys 
    1745                 1750                 1755             


Glu His  Val Asp Val Ile Ala  Lys Phe Ala Gln Leu  Glu Phe Gln 
    1760                 1765                 1770             


Leu Gly  Asp Ala Glu Arg Ala  Lys Ala Ile Phe Glu  Asn Thr Leu 
    1775                 1780                 1785             


Ser Thr  Tyr Pro Lys Arg Thr  Asp Val Trp Ser Val  Tyr Ile Asp 
    1790                 1795                 1800             


Met Thr  Ile Lys His Gly Ser  Gln Lys Asp Val Arg  Asp Ile Phe 
    1805                 1810                 1815             


Glu Arg  Val Ile His Leu Ser  Leu Ala Pro Lys Arg  Met Lys Phe 
    1820                 1825                 1830             


Phe Phe  Lys Arg Tyr Leu Asp  Tyr Glu Lys Gln His  Gly Thr Glu 
    1835                 1840                 1845             


Lys Asp  Val Gln Ala Val Lys  Ala Lys Ala Leu Glu  Tyr Val Glu 
    1850                 1855                 1860             


Ala Lys  Ser Ser Val Leu Glu  Asp 
    1865                 1870     


<210>  115
<211>  653
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (54)..(350)
<223>  

<400>  115
cccaccgctt tccgagcccg cttgcacctc ggcgatcccc gactcccttc ttt atg        56
                                                           Met          
                                                           1            

gcg tcg ctc ctg tgc tgt ggg ccg aag ctg gcc gcc tgc ggc atc gtc      104
Ala Ser Leu Leu Cys Cys Gly Pro Lys Leu Ala Ala Cys Gly Ile Val         
            5                   10                  15                  

ctc agc gcc tgg gga gtg atc atg ttg ata atg ctc gga ata ttt ttc      152
Leu Ser Ala Trp Gly Val Ile Met Leu Ile Met Leu Gly Ile Phe Phe         
        20                  25                  30                      

aat gtc cat tcc gct gtg ttg att gag gac gtt ccc ttc acg gag aaa      200
Asn Val His Ser Ala Val Leu Ile Glu Asp Val Pro Phe Thr Glu Lys         
    35                  40                  45                          

gat ttt gag aat ggc ccc cag aac ata tac aac ctt tac gag caa gtc      248
Asp Phe Glu Asn Gly Pro Gln Asn Ile Tyr Asn Leu Tyr Glu Gln Val         
50                  55                  60                  65          

agc tac aac tgt ttc atc gct gca ggc ctt tac ctc ctc ctc gga ggc      296
Ser Tyr Asn Cys Phe Ile Ala Ala Gly Leu Tyr Leu Leu Leu Gly Gly         
                70                  75                  80              

ttc tct ttc tgc caa gtt cgg ctc aat aag cgc aag gaa tac atg gtg      344
Phe Ser Phe Cys Gln Val Arg Leu Asn Lys Arg Lys Glu Tyr Met Val         
            85                  90                  95                  

cgc tag ggccccggcg cgtttccccg ctccagcccc tcctctattt aaagactccc       400
Arg                                                                     
                                                                        

tgcaccgtgt cacccaggtc gcgtcccacc cttgccggcg ccctctgtgg gactgggttt    460

cccgggcgag agactgaatc ccttctccca tctctggcat ccggcccccg tggagagggc    520

tgaggctggg gggctgttcc gtctctccac ccttcgctgt gtcccgtatc tcaataaaga    580

gaatctgctc tcttcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    640

aaaaaaaaaa aaa                                                       653


<210>  116
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Ala Ser Leu Leu Cys Cys Gly Pro Lys Leu Ala Ala Cys Gly Ile 
1               5                   10                  15      


Val Leu Ser Ala Trp Gly Val Ile Met Leu Ile Met Leu Gly Ile Phe 
            20                  25                  30          


Phe Asn Val His Ser Ala Val Leu Ile Glu Asp Val Pro Phe Thr Glu 
        35                  40                  45              


Lys Asp Phe Glu Asn Gly Pro Gln Asn Ile Tyr Asn Leu Tyr Glu Gln 
    50                  55                  60                  


Val Ser Tyr Asn Cys Phe Ile Ala Ala Gly Leu Tyr Leu Leu Leu Gly 
65                  70                  75                  80  


Gly Phe Ser Phe Cys Gln Val Arg Leu Asn Lys Arg Lys Glu Tyr Met 
                85                  90                  95      


Val Arg 
        


<210>  117
<211>  5227
<212>  DNA
<213>  Homo sapiens

<400>  117
gtttgcacaa gtagtggtgt cactttatag tttcctggac gtttgatttg gtgttcgctg     60

gagccaggtg gaggtgcctg ccctccacaa gcctgtgcta ggggcagtct taccgtggct    120

ggatttttag gagtggcttt gcagatctga ggtgaaatca tcgatagggc tgcttctgtg    180

atattttagt ctaaataccg aactcataac tcccaagcag cccggaagtt gtctggaagc    240

tctcaccgtg tacataccca agcttgactt gggcattgga gcaacggggt ccttctgctg    300

gccagactgg ggacttctgg cccagccaca tggtagctga gtgtagcgtg tggggtcagg    360

aaggttgcat tctgatctca actcttggaa gtttcctttc cccatctgtg aaagaagagg    420

atggattaga ggaggtgaaa gttcatgccc actctaaagg ccatttcact tggatctctg    480

aatctagaca tgagtaaaat gcttactgca tcttatttta taccaaacac tactgttcat    540

ttgttaaatt ggactctcat gaccatggac aaatagggaa tcaggtgtca atctgtacta    600

acttcaggac attgataata atggtaatat aatggaatgt cgatataaga ttaggtttgg    660

attttgtgaa tcaagtcttt ctttgaaaac tatgcaacat aagactgaca ggagacagtt    720

tggctatata ttattctaat aaaccaccac aaagagtaat aaaccatgac aaagagtagt    780

ctaataacct taaaccattt aagaaaagat tccaactaag aaagactgta tataattcag    840

cagaaattta tgaagtatta tatgactcat tcattcaagc tctaaaaaat acctacaagg    900

tatttaattt acttgcccat ggaaaagtga tgtggacttc ataaactata aactcttgaa    960

attaagaatg ttgttcatca aaataaaggg agtatcatga tttttaaatt taaaaaaatt   1020

tcagtgagta gcgagatagc tctaaaaagg gatttcagat tcataatgaa gaaaagtttg   1080

ttggatatta ttttctgaag gtcagtagag gcctgtaaag cagaagactg agctaactgg   1140

tgacatcatg tgggttgctg tggatttata ttaacagctg agcttgtatg ccttagtctg   1200

ggctctatgt tctaagtaaa ataaagtttc agctggtctg aatttgacgt tggcattgtt   1260

attggcgtat gttctgaaaa attaaaagtt ctgaattttt ggcaaatagg aaaattgacc   1320

aaagtcagcc atcaatgata atattattga gagtctggca tgtgccaagc agtgttcagt   1380

gttttatatt acattatttc attttattct catattcaga gaaagccaca ttatttctgt   1440

tttataagta aggaaattga gcctcaaagg gagtaaagaa cttgaccagg ttactgagcg   1500

ggtaagaatc agagttcgag tctcaacctt atccctgctt ttacctgcaa agcatcccat   1560

ccaacgcctg tcagagatgt cactcataga attctcctgt atttgccaag taaacaactc   1620

cccgaagcct ggatagcacc aagcccattt tctcactcca attagattga aatataatct   1680

aaacatgtat ttactggatt tgcaggaaca ctattttttg tttgtttttt gttgtatctg   1740

tttaaagcct tagaaccatt gctttgtttg gagtagcctg attccacttc agtcaaatac   1800

ttttttaaaa tttcatcttt ttttgacttg gggccagaca cattcacagg actccattat   1860

ctggggtttc tttgaatttg gaatgctttt aaacacttat accttatttc tgctgttact   1920

gaaaaaaatg ccaccatggt cagaaggacc tgtgctgttt tttcctttgc atctgtgagg   1980

taggccttac tgagagaggc ctgtgctggg gcctagggta aagcttcctc ctctgggaac   2040

tcccttccct tctagggttc ccccaggggt ggaggccttg ctttcccatg cctctgggat   2100

gtaggagatt ctcagtttcc tggcacaaac ggagggaagg gctgggctag ttttgtcggg   2160

gaggaggttg ctgttaggcg ggcaaatgga tccttttgct tacaactttt accattattc   2220

agttcactat ttcaatggca aatatgttgg tgagatccct tccaaatttc tctacaaata   2280

cttatacttt tgataagcac tatttaaaaa acttgttagt taaaagattt ggtagaaaaa   2340

tcagaaaata ctgactcaaa aggaagaagt ttgaaagatt cctgtaatta tattcccaga   2400

ggcagaacca cggcaattat ttacaactct tgtgactttc atggtgctac ttccctgttt   2460

gttctgtgca aatattctcc taatacatca ttttttttca ccaaatgtga gcatactaca   2520

tgcattgtag tttttctaaa cttcttttaa aactaaacaa tattttgtgg acatctttcc   2580

atgtcagtat atctggattc atatttgtag ctatctatac ttttacataa ttttaatgct   2640

ataaaatatt ccccatggat tctcacattt actccaataa ttccttacta ttagaccaaa   2700

aaatggaggc atggatattt ctattttctc tttgaccaag ctgctgttcc ttaggagggt   2760

agtataaaat atttatttgt tattttatca aacatttatt gtcttctcgg tgtcagacat   2820

tgtactttgg gcttggaata caaaaaagaa aaagacagtt tctgctcatg agggactcac   2880

agtcttatgc agacaataaa tattgtaaac agacaattac aatgatttct ttagtagaag   2940

ttggacatac attgtccctt ctaactttaa attttataga ctgatagaca aacataggaa   3000

cagaaatatt tttttccgtc tttatttatg agcaataatt tcatcttttt aaaggaaaga   3060

aattaaaaca gctataggat cctttgaggc ttttatttgt catctggtct aggagaaaca   3120

aaaaaaccac caccagtggg cctttctatg aagatcagca agaaagccct gctttctatg   3180

cctcgtggaa gggaaggttc cttctgggtt accatttgag ttgtttctca atgcgtcatt   3240

gctcctgctt tcttgttttc aagagtataa gacctagtat tggatgttga cttgagtgcc   3300

atctagcttt tttgagtcac cttacagtat ttaagcactt ttcaatgcag tgggtcagca   3360

ggggcgttca aatacagtgg tcaacctcta acagagtcct ctgaatttcc atcccttctt   3420

ctctcctgct tgctttcctt tctgtggtgg cgatgacgcc gttaggttga tgtagagagc   3480

aatgttgaca tccttgattg tcctctgact gtaagtcacc cacgttccct ttgttagcgt   3540

aaagtgggcc ctgctctcct gtgctgctcc tgtccacccc tgcttgtatg ccctcctcag   3600

aaatctcccc caccccccat gttcttggtt ttctttgctt tctgcaaatt tgttttaacc   3660

ttagtagaaa tcatggttga gtttttaaac cgtggcttag tttcttctct actcagtaag   3720

agtagcaaca ccaaaaacac cccctaccac aaaacaacgg tcaagtgtct tcctgaatat   3780

gagcagtatt tttactttaa aaggctccaa gtgctccaag actatgcttg atatactatt   3840

ttcccttagt ctccacttgt caatatttat aaagggactc tgtgcatcat ttcctttaat   3900

aaaatcaccc ttgaatcctc cataccagtc aggagatgcc aaggcacaaa acaacctgca   3960

gaaatcaggc cttgcagagc tcagtgagtg tagactctag agctttgcat cacccagata   4020

tttgcccttc acttaaactc cactcagatc acttatgtag cctggtatat gtattactca   4080

ctctttggtt ttgcacagat taagatgaaa tgacttttag aagatactgg aatctccttg   4140

ctacaggcat gtgttgccta ataaaagctt tctgcacgta cgtagtctaa taaaagatga   4200

tgaggctttc taatagccat tgctttgttt ggagtgcctg atttttattt agcacccacc   4260

tttttctgga aggaagaaat tcctaaagaa aagaagtttg caggtgccag atatctttcc   4320

tttgcttttg gacattgctt ttacattcta aataaaacag tcaaaaaaat aatttgaata   4380

ctactgcctg tttgagttca ttatttcata agaaatactg ctgatataca gttacgaagc   4440

acaccccagg ataaggtcat ttttggccat gtcgaaatgt agctttctaa cctaagcctt   4500

tgtgtgggtg tgtttttctt ccacaggaga tggcgaatat tttggctcag aagcaactgc   4560

gttccatcat tttaacagtg agtacctatg cgctgtgacc tctttgtggg ggaggagtgg   4620

cctggtgcat ttgttaatct cttcttttgg cttcagtctg tggtttgttc tgtgacttcc   4680

ttctgtggtg aagcagtagg aactctaatg aaggaaaaag tgagtttttg gaattggaat   4740

aaataaaggc tttcccacag gaattgcctc attggattgg agggaggggt ttctggaact   4800

gctctggaga gagaaagggg gaacgcattc tggccggaag ggttggatag ctctctcagt   4860

ggggcaggtt agggagatca gggcttaaaa gattcaccct gatgaggttt tgctctttca   4920

atgaggaagc tagctgtaaa catatcaggt accaagagaa gtcctgagat gttgaacatc   4980

agttttgggg gcccgcatgc aagagagagg aaggaaagat atagatagga gccactcatt   5040

cgctgcgatg caagatgacc ttaaaccttg gtggaaaaaa aaaaaagccc taagtgtcac   5100

cttgcaaatg tttagaaata aaccaaataa caagatttcc tgaggcctta cccgctattt   5160

gacttaccag ctacttgaaa gaagcaggtt gattgattgc cctgcttaca aaaaaaaaaa   5220

aaaaaaa                                                             5227


<210>  118
<211>  728
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (327)..(590)
<223>  

<400>  118
ggttgggacc ctgtggcgca tccttgtcgc tcgtgtcctt ctcatgcccg gcgacgcgtc     60

tttgtggtaa cgccctgctg ccatctcttt tcttctctat gcgaggattt ggactggcag    120

tgagaataag agacaacgat tcacgtctac tttctaggat gacttccatg tgctccatct    180

cgcgcgtccc tgagcatgtt gaatttccaa atcctaaata agccgcgcgg tgtagtttgt    240

attatgttgc gtttctcttt ctgctttcct cgccctttct ccatcatcct ttaggctcta    300

cagagtgaag gtttaaatcc aaggtc atg gca aaa cat ctg aag ttc atc gcc     353
                             Met Ala Lys His Leu Lys Phe Ile Ala        
                             1               5                          

agg act gtg atg gta cag gaa ggg aac gtg gaa agc gca tac agg acc      401
Arg Thr Val Met Val Gln Glu Gly Asn Val Glu Ser Ala Tyr Arg Thr         
10                  15                  20                  25          

cta aac aga atc ctc act atg gat ggg ctc att gag gac att aag cat      449
Leu Asn Arg Ile Leu Thr Met Asp Gly Leu Ile Glu Asp Ile Lys His         
                30                  35                  40              

cgg cgg tat tat gag aag cca tgc cgc cgg cga cag agg gaa agc tat      497
Arg Arg Tyr Tyr Glu Lys Pro Cys Arg Arg Arg Gln Arg Glu Ser Tyr         
            45                  50                  55                  

gaa agg tgc cgg cgg atc tac aac atg gaa atg gct cgc aag atc aac      545
Glu Arg Cys Arg Arg Ile Tyr Asn Met Glu Met Ala Arg Lys Ile Asn         
        60                  65                  70                      

ttc ttg atg cga aag aat cgg gca gat ccg tgg cag ggc tgc tga          590
Phe Leu Met Arg Lys Asn Arg Ala Asp Pro Trp Gln Gly Cys                 
    75                  80                  85                          

ggcctgtggg tgggacaccc agtgcgaaac cctcatccag ttttctctcc atctcttttc    650

tttgtacaat cccatttcct attaccattc tctgcaataa actcaaatca catgtctgca    710

aaaaaaaaaa aaaaaaaa                                                  728


<210>  119
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Ala Lys His Leu Lys Phe Ile Ala Arg Thr Val Met Val Gln Glu 
1               5                   10                  15      


Gly Asn Val Glu Ser Ala Tyr Arg Thr Leu Asn Arg Ile Leu Thr Met 
            20                  25                  30          


Asp Gly Leu Ile Glu Asp Ile Lys His Arg Arg Tyr Tyr Glu Lys Pro 
        35                  40                  45              


Cys Arg Arg Arg Gln Arg Glu Ser Tyr Glu Arg Cys Arg Arg Ile Tyr 
    50                  55                  60                  


Asn Met Glu Met Ala Arg Lys Ile Asn Phe Leu Met Arg Lys Asn Arg 
65                  70                  75                  80  


Ala Asp Pro Trp Gln Gly Cys 
                85          


<210>  120
<211>  972
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (3)..(461)
<223>  

<400>  120
aa gcg aag aag gaa gct cct gcc cct cct aaa gct gaa gcc aaa gcg        47
   Ala Lys Lys Glu Ala Pro Ala Pro Pro Lys Ala Glu Ala Lys Ala          
   1               5                   10                  15           

aag gct tta aag gcc aag aag gca gtg ttg aaa ggt gtc cac agc cac       95
Lys Ala Leu Lys Ala Lys Lys Ala Val Leu Lys Gly Val His Ser His         
                20                  25                  30              

aaa aag aag aag atc cgc acg tca ccc acc ttc cgg cgg ccg aag aca      143
Lys Lys Lys Lys Ile Arg Thr Ser Pro Thr Phe Arg Arg Pro Lys Thr         
            35                  40                  45                  

ctg cga ctc cgg aga cag ccc aaa tat cct cgg aag agc gct ccc agg      191
Leu Arg Leu Arg Arg Gln Pro Lys Tyr Pro Arg Lys Ser Ala Pro Arg         
        50                  55                  60                      

aga aac aag ctt gac cac tat gct atc atc aag ttt ccg ctg acc act      239
Arg Asn Lys Leu Asp His Tyr Ala Ile Ile Lys Phe Pro Leu Thr Thr         
    65                  70                  75                          

gag tct gcc atg aag aag ata gaa gac aac aac aca ctt gtg ttc att      287
Glu Ser Ala Met Lys Lys Ile Glu Asp Asn Asn Thr Leu Val Phe Ile         
80                  85                  90                  95          

gtg gat gtt aaa gcc aac aag cac cag att aaa cag gct gtg aag aag      335
Val Asp Val Lys Ala Asn Lys His Gln Ile Lys Gln Ala Val Lys Lys         
                100                 105                 110             

ctg tat gac att gat gtg gcc aag gtc aac acc ctg att cgg cct gat      383
Leu Tyr Asp Ile Asp Val Ala Lys Val Asn Thr Leu Ile Arg Pro Asp         
            115                 120                 125                 

gga gag aag aag gca tat gtt cga ctg gct cct gat tac gat gct ttg      431
Gly Glu Lys Lys Ala Tyr Val Arg Leu Ala Pro Asp Tyr Asp Ala Leu         
        130                 135                 140                     

gat gtt gcc aac aaa att ggg atc atc taa actgagtcca gctgcctaat        481
Asp Val Ala Asn Lys Ile Gly Ile Ile                                     
    145                 150                                             

tctgaatata tatatatata tatcttttca ccatatacat gcctgtctgt caatttctgg    541

ttgggctggg aggccacaca cacacactga catgacaggg cttgggcaag actcctgttc    601

tacttatcct tttgaaatac ctcaccctgc cactccacca tgtatgatca ttccagagat    661

ctttgtgact agagttagtg tcctaggaaa accagaactc agaacttgcc tccatggttg    721

agtaacaagc tgtacaagaa ccccttttat ccctggaaga ggctgtgtat gaaaccaatg    781

cccagggttt gaagggtgtt agcatccatt tcaggggagt gtggattggc tggctctctg    841

gtagcatttt gtcctcacac acccatctac tatgtccaac cggtctgtct gcttccctca    901

ccccttgccc aataaaggac aaggacttca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    961

aaaaaaaaaa a                                                         972


<210>  121
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  121

Ala Lys Lys Glu Ala Pro Ala Pro Pro Lys Ala Glu Ala Lys Ala Lys 
1               5                   10                  15      


Ala Leu Lys Ala Lys Lys Ala Val Leu Lys Gly Val His Ser His Lys 
            20                  25                  30          


Lys Lys Lys Ile Arg Thr Ser Pro Thr Phe Arg Arg Pro Lys Thr Leu 
        35                  40                  45              


Arg Leu Arg Arg Gln Pro Lys Tyr Pro Arg Lys Ser Ala Pro Arg Arg 
    50                  55                  60                  


Asn Lys Leu Asp His Tyr Ala Ile Ile Lys Phe Pro Leu Thr Thr Glu 
65                  70                  75                  80  


Ser Ala Met Lys Lys Ile Glu Asp Asn Asn Thr Leu Val Phe Ile Val 
                85                  90                  95      


Asp Val Lys Ala Asn Lys His Gln Ile Lys Gln Ala Val Lys Lys Leu 
            100                 105                 110         


Tyr Asp Ile Asp Val Ala Lys Val Asn Thr Leu Ile Arg Pro Asp Gly 
        115                 120                 125             


Glu Lys Lys Ala Tyr Val Arg Leu Ala Pro Asp Tyr Asp Ala Leu Asp 
    130                 135                 140                 


Val Ala Asn Lys Ile Gly Ile Ile 
145                 150         


<210>  122
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Ala Pro Lys Ala Lys Lys Glu Ala Pro Ala Pro Pro Lys Ala Glu 
1               5                   10                  15      


Ala Lys Ala Lys Ala Leu Lys Ala Lys Lys Ala Val Leu Lys Gly Val 
            20                  25                  30          


His Ser His Lys Lys Lys Lys Ile Arg Thr Ser Pro Thr Phe Arg Arg 
        35                  40                  45              


Pro Lys Thr Leu Arg Leu Arg Arg Gln Pro Lys Tyr Pro Arg Lys Ser 
    50                  55                  60                  


Ala Pro Arg Arg Asn Lys Leu Asp His Tyr Ala Ile Ile Asn Phe Pro 
65                  70                  75                  80  


Leu Thr Thr Glu Ser Ala Met Lys Lys Ile Glu Asp Asn Asn Thr Leu 
                85                  90                  95      


Val Phe Ile Val Asp Val Lys Ala Asn Lys His Gln Ile Ser Gln Ala 
            100                 105                 110         


Val Lys Lys Leu Tyr Asp Ile Asp Val Ala Lys Val Asn Thr Leu Ile 
        115                 120                 125             


Arg Pro Asp Gly Glu Lys Lys Ala Tyr Val Arg Leu Ala Pro Asp Tyr 
    130                 135                 140                 


Asp Ala Leu Asp Val Ala Asn Lys Ile Gly Ile Ile 
145                 150                 155     


<210>  123
<211>  2303
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (165)..(2135)
<223>  

<400>  123
ataagaaaaa aaatatttta aaagggtaac cgttaaacag ctaggacctg caacttcagt     60

gcttctggga taactggaac atcagaagga cagattttat tacagcataa tcacacctca    120

tttctttcat cagcagttgt caccagacgc tgttacttcc taaa atg gcg gac aat     176
                                                 Met Ala Asp Asn        
                                                 1                      

ctt ccc aca gag ttt gat gtg gtt ata ata ggg aca ggt ttg ccc gaa      224
Leu Pro Thr Glu Phe Asp Val Val Ile Ile Gly Thr Gly Leu Pro Glu         
5                   10                  15                  20          

tcc atc ctt gca gct gca tgt tca aga agt ggt cag agg gtt ctg cat      272
Ser Ile Leu Ala Ala Ala Cys Ser Arg Ser Gly Gln Arg Val Leu His         
                25                  30                  35              

att gat tca aga agc tac tat gga gga aac tgg gct agt ttc agc ttt      320
Ile Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala Ser Phe Ser Phe         
            40                  45                  50                  

tca gga ttg cta tcc tgg ttg aag gag tat cag caa aac aat gac att      368
Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Gln Asn Asn Asp Ile         
        55                  60                  65                      

ggg gaa gaa agt act gtt gta tgg cag gac ctg atc cat gaa aca gaa      416
Gly Glu Glu Ser Thr Val Val Trp Gln Asp Leu Ile His Glu Thr Glu         
    70                  75                  80                          

gaa gcc atc act ctt cgc aag aag gat gaa act att caa cac aca gaa      464
Glu Ala Ile Thr Leu Arg Lys Lys Asp Glu Thr Ile Gln His Thr Glu         
85                  90                  95                  100         

gct ttt ccg tac gcc agt cag gat atg gag gac aac gtt gaa gag att      512
Ala Phe Pro Tyr Ala Ser Gln Asp Met Glu Asp Asn Val Glu Glu Ile         
                105                 110                 115             

ggt gct ctg cag aaa aat cct tct ttg ggg gtg tct aat acc ttc act      560
Gly Ala Leu Gln Lys Asn Pro Ser Leu Gly Val Ser Asn Thr Phe Thr         
            120                 125                 130                 

gaa gtt ctg gat tct gca tta cct gaa gaa agc cag tta tca tat ttt      608
Glu Val Leu Asp Ser Ala Leu Pro Glu Glu Ser Gln Leu Ser Tyr Phe         
        135                 140                 145                     

aat agc gac gaa atg cct gca aaa cac act cag aaa agt gat aca gag      656
Asn Ser Asp Glu Met Pro Ala Lys His Thr Gln Lys Ser Asp Thr Glu         
    150                 155                 160                         

att tca cta gaa gta act gat gta gag gaa tca gtg gag aag gaa aag      704
Ile Ser Leu Glu Val Thr Asp Val Glu Glu Ser Val Glu Lys Glu Lys         
165                 170                 175                 180         

tat tgt gga gat aaa act tgt atg cac aca gtt tca gat aaa gat gga      752
Tyr Cys Gly Asp Lys Thr Cys Met His Thr Val Ser Asp Lys Asp Gly         
                185                 190                 195             

gat aaa gat gaa agc aaa tct aca gta gaa gat aag gcc gat gaa cca      800
Asp Lys Asp Glu Ser Lys Ser Thr Val Glu Asp Lys Ala Asp Glu Pro         
            200                 205                 210                 

att aga aat agg att act tac tct caa ata gtt aaa gaa ggc agg agg      848
Ile Arg Asn Arg Ile Thr Tyr Ser Gln Ile Val Lys Glu Gly Arg Arg         
        215                 220                 225                     

ttt aat att gat ttg gtg tca aaa ctg ctg tat tct caa gga ttg cta      896
Phe Asn Ile Asp Leu Val Ser Lys Leu Leu Tyr Ser Gln Gly Leu Leu         
    230                 235                 240                         

att gat ctt tta atc aaa tca gat gtt agt cgt tat gta gaa ttt aaa      944
Ile Asp Leu Leu Ile Lys Ser Asp Val Ser Arg Tyr Val Glu Phe Lys         
245                 250                 255                 260         

aat gtc act agg att ctt gca ttt cgg gaa gga aag gta gaa caa gtt      992
Asn Val Thr Arg Ile Leu Ala Phe Arg Glu Gly Lys Val Glu Gln Val         
                265                 270                 275             

cct tgt tcc aga gca gat gtc ttt aat agc aag gaa ctc acc atg gtt     1040
Pro Cys Ser Arg Ala Asp Val Phe Asn Ser Lys Glu Leu Thr Met Val         
            280                 285                 290                 

gaa aag agg atg cta atg aaa ttt ctc aca ttt tgt tta gag tat gaa     1088
Glu Lys Arg Met Leu Met Lys Phe Leu Thr Phe Cys Leu Glu Tyr Glu         
        295                 300                 305                     

caa cat cct gat gaa tac caa gct ttc agg cag tgt tca ttt tca gaa     1136
Gln His Pro Asp Glu Tyr Gln Ala Phe Arg Gln Cys Ser Phe Ser Glu         
    310                 315                 320                         

tac tta aaa act aaa aaa cta act ccc aac ctt caa cat ttt gta ctg     1184
Tyr Leu Lys Thr Lys Lys Leu Thr Pro Asn Leu Gln His Phe Val Leu         
325                 330                 335                 340         

cac tca att gca atg aca tca gaa tca tct tgc act aca ata gat ggt     1232
His Ser Ile Ala Met Thr Ser Glu Ser Ser Cys Thr Thr Ile Asp Gly         
                345                 350                 355             

ctt aac gca act aaa aac ttc ctt cag tgt ctc gga cgg ttt ggc aac     1280
Leu Asn Ala Thr Lys Asn Phe Leu Gln Cys Leu Gly Arg Phe Gly Asn         
            360                 365                 370                 

acc ccc ttt tta ttt ccc ttg tat ggc caa gga gaa att ccc cag ggt     1328
Thr Pro Phe Leu Phe Pro Leu Tyr Gly Gln Gly Glu Ile Pro Gln Gly         
        375                 380                 385                     

ttc tgt agg atg tgt gca gtt ttt ggt gga atc tat tgt ctt cgt cat     1376
Phe Cys Arg Met Cys Ala Val Phe Gly Gly Ile Tyr Cys Leu Arg His         
    390                 395                 400                         

aaa gta caa tgc ttt gta gtc gac aaa gaa tct gga cga tgt aaa gca     1424
Lys Val Gln Cys Phe Val Val Asp Lys Glu Ser Gly Arg Cys Lys Ala         
405                 410                 415                 420         

att ata gat cac ttt ggt caa aga ata aat gct aaa tat ttt att gtg     1472
Ile Ile Asp His Phe Gly Gln Arg Ile Asn Ala Lys Tyr Phe Ile Val         
                425                 430                 435             

gaa gac agt tac ctt tct gag gaa aca tgc tca aat gtg cag tat aag     1520
Glu Asp Ser Tyr Leu Ser Glu Glu Thr Cys Ser Asn Val Gln Tyr Lys         
            440                 445                 450                 

cag atc tct agg gca gta ctc att aca gat cag tct ata cta aag aca     1568
Gln Ile Ser Arg Ala Val Leu Ile Thr Asp Gln Ser Ile Leu Lys Thr         
        455                 460                 465                     

gat tta gat cag cag act tcc att ctg ata gtt cct cca gca gag cca     1616
Asp Leu Asp Gln Gln Thr Ser Ile Leu Ile Val Pro Pro Ala Glu Pro         
    470                 475                 480                         

gga gct tgt gct gta cgg gtc aca gaa tta tgt tct tca acc atg aca     1664
Gly Ala Cys Ala Val Arg Val Thr Glu Leu Cys Ser Ser Thr Met Thr         
485                 490                 495                 500         

tgc atg aag gac acc tat ctg gta cat ttg aca tgt tca tct tct aaa     1712
Cys Met Lys Asp Thr Tyr Leu Val His Leu Thr Cys Ser Ser Ser Lys         
                505                 510                 515             

aca gca aga gaa gac tta gaa tca gtg gtg aag aaa tta ttc act ccg     1760
Thr Ala Arg Glu Asp Leu Glu Ser Val Val Lys Lys Leu Phe Thr Pro         
            520                 525                 530                 

tat act gaa aca gaa ata aac gag gaa gaa ctt aca aag cca aga ctc     1808
Tyr Thr Glu Thr Glu Ile Asn Glu Glu Glu Leu Thr Lys Pro Arg Leu         
        535                 540                 545                     

ttg tgg gct ctt tat ttt aat atg aga gat tcc tcg gga atc agc aga     1856
Leu Trp Ala Leu Tyr Phe Asn Met Arg Asp Ser Ser Gly Ile Ser Arg         
    550                 555                 560                         

agc tcg tat aat ggc ttg cct tcc aat gtt tat gtc tgc tct ggg cct     1904
Ser Ser Tyr Asn Gly Leu Pro Ser Asn Val Tyr Val Cys Ser Gly Pro         
565                 570                 575                 580         

gac tgt ggc ctg gga aat gag cat gct gtc aag caa gct gaa aca ctt     1952
Asp Cys Gly Leu Gly Asn Glu His Ala Val Lys Gln Ala Glu Thr Leu         
                585                 590                 595             

ttc cag gag atc ttt cca act gaa gaa ttc tgc cct cca cct cca aat     2000
Phe Gln Glu Ile Phe Pro Thr Glu Glu Phe Cys Pro Pro Pro Pro Asn         
            600                 605                 610                 

cca gaa gac att atc ttt gat ggt gat gat aag cag cca gag gct cct     2048
Pro Glu Asp Ile Ile Phe Asp Gly Asp Asp Lys Gln Pro Glu Ala Pro         
        615                 620                 625                     

gga acc aat aat gta gta atg gcc aaa cta gaa tcc tct gag gaa agc     2096
Gly Thr Asn Asn Val Val Met Ala Lys Leu Glu Ser Ser Glu Glu Ser         
    630                 635                 640                         

aaa aac cta gaa agc cca gag aag cac ctt caa aat tag aaaagagcaa      2145
Lys Asn Leu Glu Ser Pro Glu Lys His Leu Gln Asn                         
645                 650                 655                             

tctcgaaatg ctgttttgga cctccttcat ggcatcagaa ttttctcatt taaaggacag   2205

tttcccatat gagtaattag aagtggttat atatgatgaa tgctatgcag atgttgtctt   2265

taactctcag acattcagca ttgaatatct ttgttaac                           2303


<210>  124
<211>  656
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Ala Asp Asn Leu Pro Thr Glu Phe Asp Val Val Ile Ile Gly Thr 
1               5                   10                  15      


Gly Leu Pro Glu Ser Ile Leu Ala Ala Ala Cys Ser Arg Ser Gly Gln 
            20                  25                  30          


Arg Val Leu His Ile Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala 
        35                  40                  45              


Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Gln 
    50                  55                  60                  


Asn Asn Asp Ile Gly Glu Glu Ser Thr Val Val Trp Gln Asp Leu Ile 
65                  70                  75                  80  


His Glu Thr Glu Glu Ala Ile Thr Leu Arg Lys Lys Asp Glu Thr Ile 
                85                  90                  95      


Gln His Thr Glu Ala Phe Pro Tyr Ala Ser Gln Asp Met Glu Asp Asn 
            100                 105                 110         


Val Glu Glu Ile Gly Ala Leu Gln Lys Asn Pro Ser Leu Gly Val Ser 
        115                 120                 125             


Asn Thr Phe Thr Glu Val Leu Asp Ser Ala Leu Pro Glu Glu Ser Gln 
    130                 135                 140                 


Leu Ser Tyr Phe Asn Ser Asp Glu Met Pro Ala Lys His Thr Gln Lys 
145                 150                 155                 160 


Ser Asp Thr Glu Ile Ser Leu Glu Val Thr Asp Val Glu Glu Ser Val 
                165                 170                 175     


Glu Lys Glu Lys Tyr Cys Gly Asp Lys Thr Cys Met His Thr Val Ser 
            180                 185                 190         


Asp Lys Asp Gly Asp Lys Asp Glu Ser Lys Ser Thr Val Glu Asp Lys 
        195                 200                 205             


Ala Asp Glu Pro Ile Arg Asn Arg Ile Thr Tyr Ser Gln Ile Val Lys 
    210                 215                 220                 


Glu Gly Arg Arg Phe Asn Ile Asp Leu Val Ser Lys Leu Leu Tyr Ser 
225                 230                 235                 240 


Gln Gly Leu Leu Ile Asp Leu Leu Ile Lys Ser Asp Val Ser Arg Tyr 
                245                 250                 255     


Val Glu Phe Lys Asn Val Thr Arg Ile Leu Ala Phe Arg Glu Gly Lys 
            260                 265                 270         


Val Glu Gln Val Pro Cys Ser Arg Ala Asp Val Phe Asn Ser Lys Glu 
        275                 280                 285             


Leu Thr Met Val Glu Lys Arg Met Leu Met Lys Phe Leu Thr Phe Cys 
    290                 295                 300                 


Leu Glu Tyr Glu Gln His Pro Asp Glu Tyr Gln Ala Phe Arg Gln Cys 
305                 310                 315                 320 


Ser Phe Ser Glu Tyr Leu Lys Thr Lys Lys Leu Thr Pro Asn Leu Gln 
                325                 330                 335     


His Phe Val Leu His Ser Ile Ala Met Thr Ser Glu Ser Ser Cys Thr 
            340                 345                 350         


Thr Ile Asp Gly Leu Asn Ala Thr Lys Asn Phe Leu Gln Cys Leu Gly 
        355                 360                 365             


Arg Phe Gly Asn Thr Pro Phe Leu Phe Pro Leu Tyr Gly Gln Gly Glu 
    370                 375                 380                 


Ile Pro Gln Gly Phe Cys Arg Met Cys Ala Val Phe Gly Gly Ile Tyr 
385                 390                 395                 400 


Cys Leu Arg His Lys Val Gln Cys Phe Val Val Asp Lys Glu Ser Gly 
                405                 410                 415     


Arg Cys Lys Ala Ile Ile Asp His Phe Gly Gln Arg Ile Asn Ala Lys 
            420                 425                 430         


Tyr Phe Ile Val Glu Asp Ser Tyr Leu Ser Glu Glu Thr Cys Ser Asn 
        435                 440                 445             


Val Gln Tyr Lys Gln Ile Ser Arg Ala Val Leu Ile Thr Asp Gln Ser 
    450                 455                 460                 


Ile Leu Lys Thr Asp Leu Asp Gln Gln Thr Ser Ile Leu Ile Val Pro 
465                 470                 475                 480 


Pro Ala Glu Pro Gly Ala Cys Ala Val Arg Val Thr Glu Leu Cys Ser 
                485                 490                 495     


Ser Thr Met Thr Cys Met Lys Asp Thr Tyr Leu Val His Leu Thr Cys 
            500                 505                 510         


Ser Ser Ser Lys Thr Ala Arg Glu Asp Leu Glu Ser Val Val Lys Lys 
        515                 520                 525             


Leu Phe Thr Pro Tyr Thr Glu Thr Glu Ile Asn Glu Glu Glu Leu Thr 
    530                 535                 540                 


Lys Pro Arg Leu Leu Trp Ala Leu Tyr Phe Asn Met Arg Asp Ser Ser 
545                 550                 555                 560 


Gly Ile Ser Arg Ser Ser Tyr Asn Gly Leu Pro Ser Asn Val Tyr Val 
                565                 570                 575     


Cys Ser Gly Pro Asp Cys Gly Leu Gly Asn Glu His Ala Val Lys Gln 
            580                 585                 590         


Ala Glu Thr Leu Phe Gln Glu Ile Phe Pro Thr Glu Glu Phe Cys Pro 
        595                 600                 605             


Pro Pro Pro Asn Pro Glu Asp Ile Ile Phe Asp Gly Asp Asp Lys Gln 
    610                 615                 620                 


Pro Glu Ala Pro Gly Thr Asn Asn Val Val Met Ala Lys Leu Glu Ser 
625                 630                 635                 640 


Ser Glu Glu Ser Lys Asn Leu Glu Ser Pro Glu Lys His Leu Gln Asn 
                645                 650                 655     


<210>  125
<211>  2853
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (24)..(779)
<223>  

<400>  125
gccactagac ctggtcagac aca atg ttg gca ctc ttg gtt ctg gtg act gtg     53
                          Met Leu Ala Leu Leu Val Leu Val Thr Val       
                          1               5                   10        

gcc ctg gca tct gct cat cat ggt ggt gag cac ttt gaa ggc gag aag      101
Ala Leu Ala Ser Ala His His Gly Gly Glu His Phe Glu Gly Glu Lys         
                15                  20                  25              

gtg ttc cgt gtt aac gtt gaa gat gaa aat cac att aac ata atc cgc      149
Val Phe Arg Val Asn Val Glu Asp Glu Asn His Ile Asn Ile Ile Arg         
            30                  35                  40                  

gag ttg gcc agc acg acc cag att gac ttc tgg aag cca gat tct gtc      197
Glu Leu Ala Ser Thr Thr Gln Ile Asp Phe Trp Lys Pro Asp Ser Val         
        45                  50                  55                      

aca caa atc aaa cct cac agt aca gtt gac ttc cgt gtt aaa gca gaa      245
Thr Gln Ile Lys Pro His Ser Thr Val Asp Phe Arg Val Lys Ala Glu         
    60                  65                  70                          

gat act gtc act gtg gag aat gtt cta aag cag aat gaa cta caa tac      293
Asp Thr Val Thr Val Glu Asn Val Leu Lys Gln Asn Glu Leu Gln Tyr         
75                  80                  85                  90          

aag gta ctg ata agc aac ctg aga aat gtg gtg gag gct cag ttt gat      341
Lys Val Leu Ile Ser Asn Leu Arg Asn Val Val Glu Ala Gln Phe Asp         
                95                  100                 105             

agc cgg gtt cgt gca aca gga cac agt tat gag aag tac aac aag tgg      389
Ser Arg Val Arg Ala Thr Gly His Ser Tyr Glu Lys Tyr Asn Lys Trp         
            110                 115                 120                 

gaa acg ata gag gct tgg act caa caa gtc gcc act gag aat cca gcc      437
Glu Thr Ile Glu Ala Trp Thr Gln Gln Val Ala Thr Glu Asn Pro Ala         
        125                 130                 135                     

ctc atc tct cgc agt gtt atc gga acc aca ttt gag gga cgc gct att      485
Leu Ile Ser Arg Ser Val Ile Gly Thr Thr Phe Glu Gly Arg Ala Ile         
    140                 145                 150                         

tac ctc ctg aag gtt ggc aaa gct gga caa aat aag cct gcc att ttc      533
Tyr Leu Leu Lys Val Gly Lys Ala Gly Gln Asn Lys Pro Ala Ile Phe         
155                 160                 165                 170         

atg gac tgt ggt ttc cat gcc aga gag tgg att tct cct gca ttc tgc      581
Met Asp Cys Gly Phe His Ala Arg Glu Trp Ile Ser Pro Ala Phe Cys         
                175                 180                 185             

cag tgg ttt gta aga gag gct gtt cgt acc tat gga cgt gag atc caa      629
Gln Trp Phe Val Arg Glu Ala Val Arg Thr Tyr Gly Arg Glu Ile Gln         
            190                 195                 200                 

gtg aca gag ctt ctc aac aag tta gac ttt tat gtc ctg cct gtg ctc      677
Val Thr Glu Leu Leu Asn Lys Leu Asp Phe Tyr Val Leu Pro Val Leu         
        205                 210                 215                     

aat att gat ggc tac atc tac acc tgg acc aag gta tat gca cca ata      725
Asn Ile Asp Gly Tyr Ile Tyr Thr Trp Thr Lys Val Tyr Ala Pro Ile         
    220                 225                 230                         

ctg aga caa gct gat gaa att aaa acc aac gcc tct cta tta tat ttg      773
Leu Arg Gln Ala Asp Glu Ile Lys Thr Asn Ala Ser Leu Leu Tyr Leu         
235                 240                 245                 250         

tcc taa ctatgtagtc cactttcaga gccgattttg gagaaagact cgctccaccc       829
Ser                                                                     
                                                                        

atactggatc tagctgcatt ggcacagacc ccaacagaaa ttttgatgct ggttggtgtg    889

aaattggagc ctctcgaaac ccctgtgatg aaacttactg tggacctgcc gcagagtctg    949

aaaaggagac caaggccctg gctgatttca tccgcaacaa actctcttcc atcaaggcat   1009

atctgacaat ccactcgtac tcccaaatga tgatctaccc ttactcatat gcttacaaac   1069

tcggtgagaa caatgctgag ttggtaagta gcaaagtagt aggtatgaca ttttactatt   1129

gagatttttt aaattctaat cctgaaaaaa aaatcattat aagaacactt tctggaagtc   1189

cctttattga tttttttggt agtagaattg aaaaacttat tacagattta taaggaatct   1249

ggagttggct aaaagaaata caattttcac gcaggaaatt gttccccaca tgcgatttat   1309

tgactaatct tcaaaatgac aatagttcca tttcctctgg cttcaccaca atgctgactt   1369

acatgatgat ttcagatgca tatgagataa tcaacaaagt tgcttgatca catacatatt   1429

tttttttcag tcagttttgt gaagctgccc tgagctgaat ttgacacaga tccagagcat   1489

agcagagcac agcagatgtc attaggaatt tgtcacattt gggtgatatc aagtttagtc   1549

attaaatact aaaattgttt atttcacttt ttgattgggt gagactcaaa agtaaatcaa   1609

tcaatgaaca aataatgtga atgagtcttt accacataca gggaataaag caaagaaatg   1669

taagaatctc tgacatcaaa aaaagctagc aatcttattg aacaatcaag acataatcac   1729

ttgagcagct aaataatgag ttttctcata gaaatatcac atgtcaatga ataatttttt   1789

aaataagcat gtttgaacct ttcaaacaat atttctttaa tttatgaaac atctggctgc   1849

cagaaattgg caccaataaa ctaaaagagc aaatataaga tttaaagcat ttgagttatg   1909

ccaaaaaaaa aaatgtattc catttagaca atgacatgga tatttggctt acctaaatgc   1969

ataaatttga agacctagta actttaaaac tgaaaattgt tgttttatac tttcagattc   2029

agtctttcgg agaccaaata aaatatgtaa tgccgtaaat attttgagaa caaatcagaa   2089

aaataaccca gtctcctaga aaattgatag ctaatagttg gatgggccct tttctttaaa   2149

aaacaataca atttttcaaa aagcttttca tttttcccca tccatggcca aaaatatata   2209

tatatataca tatatatata tacacatata tatgtgtgtg tgtgtgtgtg tatgtatata   2269

tatatatata tatatatata tatatatata tatatatgtt agcaccgcca agcatttcag   2329

tttttcactt aagcttggtc tgtatgtgtt cccaatgggt gctcacagta ttgttctccc   2389

agagatgggt gtggttggct ctcatttctg tccaaaattt ctggccacca gaaaagagga   2449

ggtgggggta tgtagtttgt ataactcatg taaatatatt taagttgtgc catatcagaa   2509

gagaaaaagt caaagtcata actacatact aatgagttaa ttaaaataaa aaaattacaa   2569

aacacattaa gggtagcaat aacatatata tatccagttt gcttcaatat caactagttt   2629

tagacataac tactaaaaga ctaacactaa agaataaagt ttaaagtgtt cctggaagct   2689

gagctaccaa agttttctta ttcaatacat tttcttattg gaggaataag tttaagccct   2749

tttagtgatg agacagcttt gttgccacta gttgtataca ataacaacca gaacctgggc   2809

tactctaaaa gtctccaaat cttcttaaaa aaaaaaaaaa aaaa                    2853


<210>  126
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Leu Ala Leu Leu Val Leu Val Thr Val Ala Leu Ala Ser Ala His 
1               5                   10                  15      


His Gly Gly Glu His Phe Glu Gly Glu Lys Val Phe Arg Val Asn Val 
            20                  25                  30          


Glu Asp Glu Asn His Ile Asn Ile Ile Arg Glu Leu Ala Ser Thr Thr 
        35                  40                  45              


Gln Ile Asp Phe Trp Lys Pro Asp Ser Val Thr Gln Ile Lys Pro His 
    50                  55                  60                  


Ser Thr Val Asp Phe Arg Val Lys Ala Glu Asp Thr Val Thr Val Glu 
65                  70                  75                  80  


Asn Val Leu Lys Gln Asn Glu Leu Gln Tyr Lys Val Leu Ile Ser Asn 
                85                  90                  95      


Leu Arg Asn Val Val Glu Ala Gln Phe Asp Ser Arg Val Arg Ala Thr 
            100                 105                 110         


Gly His Ser Tyr Glu Lys Tyr Asn Lys Trp Glu Thr Ile Glu Ala Trp 
        115                 120                 125             


Thr Gln Gln Val Ala Thr Glu Asn Pro Ala Leu Ile Ser Arg Ser Val 
    130                 135                 140                 


Ile Gly Thr Thr Phe Glu Gly Arg Ala Ile Tyr Leu Leu Lys Val Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Asn Lys Pro Ala Ile Phe Met Asp Cys Gly Phe His 
                165                 170                 175     


Ala Arg Glu Trp Ile Ser Pro Ala Phe Cys Gln Trp Phe Val Arg Glu 
            180                 185                 190         


Ala Val Arg Thr Tyr Gly Arg Glu Ile Gln Val Thr Glu Leu Leu Asn 
        195                 200                 205             


Lys Leu Asp Phe Tyr Val Leu Pro Val Leu Asn Ile Asp Gly Tyr Ile 
    210                 215                 220                 


Tyr Thr Trp Thr Lys Val Tyr Ala Pro Ile Leu Arg Gln Ala Asp Glu 
225                 230                 235                 240 


Ile Lys Thr Asn Ala Ser Leu Leu Tyr Leu Ser 
                245                 250     


<210>  127
<211>  3051
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (35)..(607)
<223>  

<400>  127
ggcgcgcggc gagctgaggg tggcggcggt cgac atg ttc cag gtc ccg gat agc     55
                                      Met Phe Gln Val Pro Asp Ser       
                                      1               5                 

gag ggc ggc cgc gcc ggc tcc agg gcc atg aag ccc cca gga gga gaa      103
Glu Gly Gly Arg Ala Gly Ser Arg Ala Met Lys Pro Pro Gly Gly Glu         
        10                  15                  20                      

tcg agc aat ctt ttt gga agt cca gaa gaa gct act cct tcc agc agg      151
Ser Ser Asn Leu Phe Gly Ser Pro Glu Glu Ala Thr Pro Ser Ser Arg         
    25                  30                  35                          

cct aat agg atg gca tct aat att ttt gga cca aca gaa gaa cct cag      199
Pro Asn Arg Met Ala Ser Asn Ile Phe Gly Pro Thr Glu Glu Pro Gln         
40                  45                  50                  55          

aac ata ccc aag agg aca aat ccc cca ggg ggt aaa gga agt ggt atc      247
Asn Ile Pro Lys Arg Thr Asn Pro Pro Gly Gly Lys Gly Ser Gly Ile         
                60                  65                  70              

ttt gac gaa tca acc ccc gtg cag act cga cag cac ctg aac cca cct      295
Phe Asp Glu Ser Thr Pro Val Gln Thr Arg Gln His Leu Asn Pro Pro         
            75                  80                  85                  

gga ggg aag acc agc gac att ttt ggg tct ccg gtc act gcc act tca      343
Gly Gly Lys Thr Ser Asp Ile Phe Gly Ser Pro Val Thr Ala Thr Ser         
        90                  95                  100                     

cgc ttg gca cac cca aac aaa ccc aag gat cat gtt ttc tta tgt gaa      391
Arg Leu Ala His Pro Asn Lys Pro Lys Asp His Val Phe Leu Cys Glu         
    105                 110                 115                         

gga gaa gaa cca aaa tcg gat ctt aaa gct gca agg agc atc ccg gct      439
Gly Glu Glu Pro Lys Ser Asp Leu Lys Ala Ala Arg Ser Ile Pro Ala         
120                 125                 130                 135         

gga gca gag cca ggt gag aaa ggc agc gcc aga aaa gca ggc ccc gcc      487
Gly Ala Glu Pro Gly Glu Lys Gly Ser Ala Arg Lys Ala Gly Pro Ala         
                140                 145                 150             

aag gag cag gag ccc atg ccc aca gtc gac agc cat gag ccc cgg ctg      535
Lys Glu Gln Glu Pro Met Pro Thr Val Asp Ser His Glu Pro Arg Leu         
            155                 160                 165                 

ggg ccg cgg cct cgc tct cac aac aag gtc ctg aac cca ccg gga ggc      583
Gly Pro Arg Pro Arg Ser His Asn Lys Val Leu Asn Pro Pro Gly Gly         
        170                 175                 180                     

aaa tcc agc atc tcc ttc tac taa gagaagccac tgctccaccc ggagccagac     637
Lys Ser Ser Ile Ser Phe Tyr                                             
    185                 190                                             

cagaaactca agagataggg tagccatgtt ttcatttcct tttgcccaaa tgagcggggt    697

gggaagaggg ttagtcttat gtgagcctgg ctgctcagcg tctcctggcc gtcatgacag    757

ctgcttggag acccgtgcct tccagatggc tgggagatgc ctctgtgggg atgaaatggg    817

gcacccctgg ccatcactca tgtgtagtcc aggtttgaga ggaactggaa ggggggtgag    877

ggtggggagg tggggcaggg catggtcctt ggatcaacag cccgccagct gattggatgt    937

ctaggaatga ctgaaagaaa ccaaaacagc ctgtccactg ctgctgtggg atggaggagg    997

cgtaagcaga aacactaaca gtatattgac ctcttagcag aaccgcttcc attctggaga   1057

tcacggctgc taaatccagc atccccactt cattttaccc ccagcatatt gttctgtagt   1117

cttttcttga aacatcttga ttgcttttcc tcggcagctt tcaaaaaacc aaataataat   1177

agttatccgt cttctacttc atggaagatt gttttggtgc cctgaccctc tgaagtgccc   1237

agttcctgcc atctgaaacc tcggcctgat ctgatctcat gttggaatct gcctgtcttt   1297

cacacagggc tggtcttggt cctttacatg ccagttttgc ttgtgaattc ttgctttttt   1357

cctctcatca gccttaagtt taggcgtttg ttgttctcca gtgatgtaga cagttccctt   1417

cacaagtcac agttcttccc ataaatgagg cccgctgacc tctgcgggac tttaaaaatc   1477

tattcagata tttccgagta agtggcttgt ttaaattctt cctgtgtctt tctttattcc   1537

ttaattggtt ggtggaaaga agagatgctt gggaaccttg ggttcttagg tttggattct   1597

ttaataatat ctaaaaagct aaattttaaa taccagcttt acataaatga ttgttgactc   1657

tggtctgttt ctgacacctt tccagaaaaa agtcaattgt tcaggtacac caaagaggaa   1717

gaagagctgt ggaggccacc ctctacaaag ctttatagaa cttctggatc taactcacaa   1777

acaagcttcc agaagagact agagacctta ggccaggaga tgaaggagtt cagtagcaaa   1837

gtcacacctg tccaattccc tgagctttgc tcactcagct aatgggatgg caaaggtggt   1897

ggtgctttca tcttcaggca gaagcctctg cccatccccc tcaagggctg caggcccagt   1957

tctcatgctg cccttgggtg ggcatctgtt aacagaggag aacgtctggg tggcggcagc   2017

agctttgctc tgagtgccta caaagctaat gcttggtgct agaaacatca tcattattaa   2077

acttcagaaa agcagcagcc atgttcagtc aggctcatgc tgcctcactg cttaagtgcc   2137

tgcaggagcc gcctgccaag ctccccttcc tacacctggc acactggggt ctgcacaagg   2197

ctttgtcaac caaagacagc ttcccccttt tgattgcctg tagactttgg agccaagaaa   2257

cactctgtgt gactctacac acacttcagg tggtttgtgc ttcaaagtca ttgatgcaac   2317

ttgaaaggaa acagtttaat ggtggaaatg aactaccatt tataacttct gtttttttat   2377

tgagaaaatg attcacgaat tccaaatcag attgccagga agaaatagga cgtgacggta   2437

ctgggccctg tgattctccc agcccttgca gtccgctagg tgagaggaaa agctctttac   2497

ttccgcccct ggcagggact tctgggttat gggagaaacc agagatggga atgaggaaaa   2557

tatgaactac agcagaagcc cctgggcagc tgtgatggag cccctgacat tactcttctt   2617

gcatctgtcc tgccttcttt ccctctgcga ggcagtgggg tgggattcag agtgcttagt   2677

ctgctcactg ggagaagaag agttcctgcg catgcaagcc ctgctgtgtg gctgtcgttt   2737

acatttggga ggtgtcctgt atgtctgtac gttggggact gcctgtattt ggaagattta   2797

aaaacctagc atcctgttct caccctctaa gctgcattga gaaatgactc gtctctgtat   2857

ttgtattaag ccttaacact tttcttaagt gcattcggtg ccaacatttt ttagagctgt   2917

accaaaacaa aaagcctgta ctcacatcac aatgtcattt tgataggagc gttttgttat   2977

ttttacaagg cagaatgggg tgtaacagtt gaattaaact tagcaatcac gtgctcaaaa   3037

aaaaaaaaaa aaaa                                                     3051


<210>  128
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Phe Gln Val Pro Asp Ser Glu Gly Gly Arg Ala Gly Ser Arg Ala 
1               5                   10                  15      


Met Lys Pro Pro Gly Gly Glu Ser Ser Asn Leu Phe Gly Ser Pro Glu 
            20                  25                  30          


Glu Ala Thr Pro Ser Ser Arg Pro Asn Arg Met Ala Ser Asn Ile Phe 
        35                  40                  45              


Gly Pro Thr Glu Glu Pro Gln Asn Ile Pro Lys Arg Thr Asn Pro Pro 
    50                  55                  60                  


Gly Gly Lys Gly Ser Gly Ile Phe Asp Glu Ser Thr Pro Val Gln Thr 
65                  70                  75                  80  


Arg Gln His Leu Asn Pro Pro Gly Gly Lys Thr Ser Asp Ile Phe Gly 
                85                  90                  95      


Ser Pro Val Thr Ala Thr Ser Arg Leu Ala His Pro Asn Lys Pro Lys 
            100                 105                 110         


Asp His Val Phe Leu Cys Glu Gly Glu Glu Pro Lys Ser Asp Leu Lys 
        115                 120                 125             


Ala Ala Arg Ser Ile Pro Ala Gly Ala Glu Pro Gly Glu Lys Gly Ser 
    130                 135                 140                 


Ala Arg Lys Ala Gly Pro Ala Lys Glu Gln Glu Pro Met Pro Thr Val 
145                 150                 155                 160 


Asp Ser His Glu Pro Arg Leu Gly Pro Arg Pro Arg Ser His Asn Lys 
                165                 170                 175     


Val Leu Asn Pro Pro Gly Gly Lys Ser Ser Ile Ser Phe Tyr 
            180                 185                 190 


<210>  129
<211>  4524
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (276)..(1784)
<223>  

<400>  129
gcgcggggcg cggagtcggc ggggcctcgc gggacgccgg gcagtgcgga gaccgcggcg     60

ctgaggacgc gggagccggg agcgcagccg cggggtggag ttcagcctac tctttcttag    120

atgtgaaagg aaaggaagat catttcatgc cttgttgata aaggttcaga cttctgctga    180

ttcataacca tttggctctg agctatgaca agagaggaaa caaaaagtta aacaagcaag    240

cctgccataa gtgagaagca aacttccttg ataac atg ctt ttg cga agt gca       293
                                       Met Leu Leu Arg Ser Ala          
                                       1               5                

gga aaa tta aat gtg ggc acc aag aaa gag gat ggt gag agt aca gcc      341
Gly Lys Leu Asn Val Gly Thr Lys Lys Glu Asp Gly Glu Ser Thr Ala         
            10                  15                  20                  

ccc acc ccc cgt cca aag gtc ttg cgt tgt aaa tgc cac cac cat tgt      389
Pro Thr Pro Arg Pro Lys Val Leu Arg Cys Lys Cys His His His Cys         
        25                  30                  35                      

cca gaa gac tca gtc aac aat att tgc agc aca gac gga tat tgt ttc      437
Pro Glu Asp Ser Val Asn Asn Ile Cys Ser Thr Asp Gly Tyr Cys Phe         
    40                  45                  50                          

acg atg ata gaa gag gat gac tct ggg ttg cct gtg gtc act tct ggt      485
Thr Met Ile Glu Glu Asp Asp Ser Gly Leu Pro Val Val Thr Ser Gly         
55                  60                  65                  70          

tgc cta gga cta gaa ggc tca gat ttt cag tgt cgg gac act ccc att      533
Cys Leu Gly Leu Glu Gly Ser Asp Phe Gln Cys Arg Asp Thr Pro Ile         
                75                  80                  85              

cct cat caa aga aga tca att gaa tgc tgc aca gaa agg aac gaa tgt      581
Pro His Gln Arg Arg Ser Ile Glu Cys Cys Thr Glu Arg Asn Glu Cys         
            90                  95                  100                 

aat aaa gac cta cac cct aca ctg cct cca ttg aaa aac aga gat ttt      629
Asn Lys Asp Leu His Pro Thr Leu Pro Pro Leu Lys Asn Arg Asp Phe         
        105                 110                 115                     

gtt gat gga cct ata cac cac agg gct tta ctt ata tct gtg act gtc      677
Val Asp Gly Pro Ile His His Arg Ala Leu Leu Ile Ser Val Thr Val         
    120                 125                 130                         

tgt agt ttg ctc ttg gtc ctt atc ata tta ttt tgt tac ttc cgg tat      725
Cys Ser Leu Leu Leu Val Leu Ile Ile Leu Phe Cys Tyr Phe Arg Tyr         
135                 140                 145                 150         

aaa aga caa gaa acc aga cct cga tac agc att ggg tta gaa cag gat      773
Lys Arg Gln Glu Thr Arg Pro Arg Tyr Ser Ile Gly Leu Glu Gln Asp         
                155                 160                 165             

gaa act tac att cct cct gga gaa tcc ctg aga gac tta att gag cag      821
Glu Thr Tyr Ile Pro Pro Gly Glu Ser Leu Arg Asp Leu Ile Glu Gln         
            170                 175                 180                 

tct cag agc tca gga agt gga tca ggc ctc cct ctg ctg gtc caa agg      869
Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu Pro Leu Leu Val Gln Arg         
        185                 190                 195                     

act ata gct aag cag att cag atg gtg aaa cag att gga aaa ggt cgc      917
Thr Ile Ala Lys Gln Ile Gln Met Val Lys Gln Ile Gly Lys Gly Arg         
    200                 205                 210                         

tat ggg gaa gtt tgg atg gga aag tgg cgt ggc gaa aag gta gct gtg      965
Tyr Gly Glu Val Trp Met Gly Lys Trp Arg Gly Glu Lys Val Ala Val         
215                 220                 225                 230         

aaa gtg ttc ttc acc aca gag gaa gcc agc tgg ttc aga gag aca gaa     1013
Lys Val Phe Phe Thr Thr Glu Glu Ala Ser Trp Phe Arg Glu Thr Glu         
                235                 240                 245             

ata tat cag aca gtg ttg atg agg cat gaa aac att ttg ggt ttc att     1061
Ile Tyr Gln Thr Val Leu Met Arg His Glu Asn Ile Leu Gly Phe Ile         
            250                 255                 260                 

gct gca gat atc aaa ggg aca ggg tcc tgg acc cag ttg tac cta atc     1109
Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp Thr Gln Leu Tyr Leu Ile         
        265                 270                 275                     

aca gac tat cat gaa aat ggt tcc ctt tat gat tat ctg aag tcc acc     1157
Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr Asp Tyr Leu Lys Ser Thr         
    280                 285                 290                         

acc cta gac gct aaa tca atg ctg aag tta gcc tac tct tct gtc agt     1205
Thr Leu Asp Ala Lys Ser Met Leu Lys Leu Ala Tyr Ser Ser Val Ser         
295                 300                 305                 310         

ggc tta tgt cat tta cac aca gaa atc ttt agt act caa ggc aaa cca     1253
Gly Leu Cys His Leu His Thr Glu Ile Phe Ser Thr Gln Gly Lys Pro         
                315                 320                 325             

gca att gcc cat cga gat ctg aaa agt aaa aac att ctg gtg aag aaa     1301
Ala Ile Ala His Arg Asp Leu Lys Ser Lys Asn Ile Leu Val Lys Lys         
            330                 335                 340                 

aat gga act tgc tgt att gct gac ctg ggc ctg gct gtt aaa ttt att     1349
Asn Gly Thr Cys Cys Ile Ala Asp Leu Gly Leu Ala Val Lys Phe Ile         
        345                 350                 355                     

agt gat aca aat gaa gtt gac ata cca cct aac act cga gtt ggc acc     1397
Ser Asp Thr Asn Glu Val Asp Ile Pro Pro Asn Thr Arg Val Gly Thr         
    360                 365                 370                         

aaa cgc tat atg cct cca gaa gtg ttg gac gag agc ttg aac aga aat     1445
Lys Arg Tyr Met Pro Pro Glu Val Leu Asp Glu Ser Leu Asn Arg Asn         
375                 380                 385                 390         

cac ttc cag tct tac atc atg gct gac atg tat agt ttt ggc ctc atc     1493
His Phe Gln Ser Tyr Ile Met Ala Asp Met Tyr Ser Phe Gly Leu Ile         
                395                 400                 405             

ctt tgg gag gtt gct agg aga tgt gta tca gga ggt ata gtg gaa gaa     1541
Leu Trp Glu Val Ala Arg Arg Cys Val Ser Gly Gly Ile Val Glu Glu         
            410                 415                 420                 

tac cag ctt cct tat cat gac cta gtg ccc agt gac ccc tct tat gag     1589
Tyr Gln Leu Pro Tyr His Asp Leu Val Pro Ser Asp Pro Ser Tyr Glu         
        425                 430                 435                     

gac atg agg gag att gtg tgc atc aag aag tta cgc ccc tca ttc cca     1637
Asp Met Arg Glu Ile Val Cys Ile Lys Lys Leu Arg Pro Ser Phe Pro         
    440                 445                 450                         

aac cgg tgg agc agt gat gag tgt cta agg cag atg gga aaa ctc atg     1685
Asn Arg Trp Ser Ser Asp Glu Cys Leu Arg Gln Met Gly Lys Leu Met         
455                 460                 465                 470         

aca gaa tgc tgg gct cac aat cct gca tca agg ctg aca gcc ctg cgg     1733
Thr Glu Cys Trp Ala His Asn Pro Ala Ser Arg Leu Thr Ala Leu Arg         
                475                 480                 485             

gtt aag aaa aca ctt gcc aaa atg tca gag tcc cag gac att aaa ctc     1781
Val Lys Lys Thr Leu Ala Lys Met Ser Glu Ser Gln Asp Ile Lys Leu         
            490                 495                 500                 

tga taggagagga aaagtaagca tctctgcaga aagccaacag ttatattctt          1834

agggatagcc tagaaggaat atatggttag aactaagtgt gactaatcat ctgagccttg   1894

aagagaaact tcagtgcctc taaacagatc atctacaaaa caacaggtaa acatttatgc   1954

cagttaagtg ggtcatgttt ttgtttcttg ggtttttcct aaatttaagt gaggttgggc   2014

ttaccttgta gataaaatta tgttttcttt ttggtaaata cttgaatgtg gataacgtca   2074

aatcagaata ttttgtgagg aggtgatgat ttgaaattaa gctagatttc tagggaggtg   2134

ttggttccaa tgaaggatgg gaagaaatta aaatagtctt caaacttctt ccttattata   2194

tttggttgct ttggaaaaga ttggtcctat cctcaatcta atttattcac tattaatatt   2254

ttaaaaacat tcctgagata cttaaaaaga cccacttagc gattatagtt gctcaatgaa   2314

acaagaattt atttatgcat agatttttct ctgtatctta ccaaaatcca ctttacttag   2374

ataacactaa attgttctta aagactactc atttcccaat aatcctttat gatttcaaaa   2434

tttctagtgg ctcagaagtg aattttattt tatttgtctt tcacttgaat aagtgagaac   2494

ccagaaatta ataatgttgt ttattgctta ctgtcaggac tatttcaaag actaagaaga   2554

gtttcttcta acccctccct ctcaaaggaa tcctaaatta ttagttgtta gataagtttt   2614

gtatgctaag atattcaggt ttatagttta tgtatgtgtg tatatatata aatatatatg   2674

tatatataaa tattatgttc agtttggagt ctggcacaac tccattatgt ggattagaga   2734

gtaagatatt atggatgata aagtactaaa tgaaacataa tatttattta taaaagtgtg   2794

tagattgtta aatcacaaaa agagtgctat gaccattatg tatgaggaaa caggcctttg   2854

acctcctgga aagcactgct caaaagtcat tagtgcccat ttttgaattc cccaaacaga   2914

aagcttctta gaaaacacgc tgagatttta tttacaggga attctttgac acatttcaat   2974

tggtgtgtag tcaagtatag caagtactta ataatgactg aatttcatgt tcctacagtc   3034

atacatattc attagaagtt ttatgttgtt ggtctgatct gattcttctt tgtttgtggg   3094

tggaacggca ctgagagaag tatagttttt taaacttgaa catgttcagt agttacattg   3154

ccttagaaaa cccagacaca tagcagtgga aatgaaagaa atggcatcag aagtgactta   3214

atttagcaat tgtgattcct cttgtaaaac aaaacaaaaa aacaatgcca tattttttgg   3274

agaaaagttg gcaatatagg ggtttcgttg tctgtttcac aagaagactc atttgttctt   3334

ttgggggaac cagtgcctta cagattttgt atatactgta attattcagg actagggaac   3394

aaacaattgt attgtatttg ttacagattg tatatggctt tgttttaaca ttcccctaaa   3454

taaaatggct tcattctccc cttggaaaaa aacatgactg ttatgttata gttgtgctta   3514

tttatttatt tatttattta tttattatct ttgaaaatat cccattgtag caggtgggaa   3574

ggcaccatga aggaggcaga tgcaggtaag tttttcacat ttcatggcag gaggacaaga   3634

gaaatggtct gatggcttct actttctttg tgaaggaaac acagtcatct actgagagtg   3694

aggggaaagg cagggaagtc agtggtttaa gagaagtgaa gaaggtttaa aattgcactg   3754

gaaaattaca gcttgatggg gaaagagcca gatggttacg ggcaactctg agggccaggt   3814

taggcttcct gaagctgact gtggcacagt ggccaagcgt agacttggga ctgccaggtg   3874

gcctgttggt gtgaatccag cttccctcac tccctcagtt gtgtgactgg gcacattttg   3934

acctctttat catgcaaatg cagcaacagg tcatggaaag taagaattat tactatcaag   3994

gggctgatgg gccagaggag ggaaggaatt aattagagga gctaacagac caacaaacaa   4054

acaaacaaac gaacaaaaaa cccaggtccc aggacaggga atcctgatgg ggcggaggtg   4114

gtatctccgc agttactgag agaggggctg tggtcagttt cttccccttg aagatgtttc   4174

ttccccttga agatgagaat gatgttaata tccactatct ggagttgttc tgaagatgaa   4234

atgacataat ccatgcacca agcatgtggt aagtgctcaa ctatagtatt aacagaaatt   4294

catagtgcca cttttcttgt ggtttatgat tttttttatc tttttgtcag caacccaaat   4354

acaggtatag agacaacgaa gataggattc attcagggta ctggtttatc atgcaaacgc   4414

agcaacaggt catggaaggt aagaattatt actatcaagg ggctgatgga ccagaggagg   4474

gaaggaatta attagaggag ctaacagacc aaaaaaaaaa aaaaaaaaaa              4524


<210>  130
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Leu Leu Arg Ser Ala Gly Lys Leu Asn Val Gly Thr Lys Lys Glu 
1               5                   10                  15      


Asp Gly Glu Ser Thr Ala Pro Thr Pro Arg Pro Lys Val Leu Arg Cys 
            20                  25                  30          


Lys Cys His His His Cys Pro Glu Asp Ser Val Asn Asn Ile Cys Ser 
        35                  40                  45              


Thr Asp Gly Tyr Cys Phe Thr Met Ile Glu Glu Asp Asp Ser Gly Leu 
    50                  55                  60                  


Pro Val Val Thr Ser Gly Cys Leu Gly Leu Glu Gly Ser Asp Phe Gln 
65                  70                  75                  80  


Cys Arg Asp Thr Pro Ile Pro His Gln Arg Arg Ser Ile Glu Cys Cys 
                85                  90                  95      


Thr Glu Arg Asn Glu Cys Asn Lys Asp Leu His Pro Thr Leu Pro Pro 
            100                 105                 110         


Leu Lys Asn Arg Asp Phe Val Asp Gly Pro Ile His His Arg Ala Leu 
        115                 120                 125             


Leu Ile Ser Val Thr Val Cys Ser Leu Leu Leu Val Leu Ile Ile Leu 
    130                 135                 140                 


Phe Cys Tyr Phe Arg Tyr Lys Arg Gln Glu Thr Arg Pro Arg Tyr Ser 
145                 150                 155                 160 


Ile Gly Leu Glu Gln Asp Glu Thr Tyr Ile Pro Pro Gly Glu Ser Leu 
                165                 170                 175     


Arg Asp Leu Ile Glu Gln Ser Gln Ser Ser Gly Ser Gly Ser Gly Leu 
            180                 185                 190         


Pro Leu Leu Val Gln Arg Thr Ile Ala Lys Gln Ile Gln Met Val Lys 
        195                 200                 205             


Gln Ile Gly Lys Gly Arg Tyr Gly Glu Val Trp Met Gly Lys Trp Arg 
    210                 215                 220                 


Gly Glu Lys Val Ala Val Lys Val Phe Phe Thr Thr Glu Glu Ala Ser 
225                 230                 235                 240 


Trp Phe Arg Glu Thr Glu Ile Tyr Gln Thr Val Leu Met Arg His Glu 
                245                 250                 255     


Asn Ile Leu Gly Phe Ile Ala Ala Asp Ile Lys Gly Thr Gly Ser Trp 
            260                 265                 270         


Thr Gln Leu Tyr Leu Ile Thr Asp Tyr His Glu Asn Gly Ser Leu Tyr 
        275                 280                 285             


Asp Tyr Leu Lys Ser Thr Thr Leu Asp Ala Lys Ser Met Leu Lys Leu 
    290                 295                 300                 


Ala Tyr Ser Ser Val Ser Gly Leu Cys His Leu His Thr Glu Ile Phe 
305                 310                 315                 320 


Ser Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser Lys 
                325                 330                 335     


Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu Gly 
            340                 345                 350         


Leu Ala Val Lys Phe Ile Ser Asp Thr Asn Glu Val Asp Ile Pro Pro 
        355                 360                 365             


Asn Thr Arg Val Gly Thr Lys Arg Tyr Met Pro Pro Glu Val Leu Asp 
    370                 375                 380                 


Glu Ser Leu Asn Arg Asn His Phe Gln Ser Tyr Ile Met Ala Asp Met 
385                 390                 395                 400 


Tyr Ser Phe Gly Leu Ile Leu Trp Glu Val Ala Arg Arg Cys Val Ser 
                405                 410                 415     


Gly Gly Ile Val Glu Glu Tyr Gln Leu Pro Tyr His Asp Leu Val Pro 
            420                 425                 430         


Ser Asp Pro Ser Tyr Glu Asp Met Arg Glu Ile Val Cys Ile Lys Lys 
        435                 440                 445             


Leu Arg Pro Ser Phe Pro Asn Arg Trp Ser Ser Asp Glu Cys Leu Arg 
    450                 455                 460                 


Gln Met Gly Lys Leu Met Thr Glu Cys Trp Ala His Asn Pro Ala Ser 
465                 470                 475                 480 


Arg Leu Thr Ala Leu Arg Val Lys Lys Thr Leu Ala Lys Met Ser Glu 
                485                 490                 495     


Ser Gln Asp Ile Lys Leu 
            500         


<210>  131
<211>  1076
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (176)..(778)
<223>  

<400>  131
gctgcccggg cagcggggga gcagcgagcg ggcttccgcg agccggagaa ggcacaggcc     60

tgtcccgggt cccggcaggt ctgcgcgtct gttcccagcg ctctgcgagg cctaaaaagg    120

aggagcaacc tgtccagaat ccctgcagga caggaaaagg aggggaaatc tcgac atg     178
                                                             Met        
                                                             1          

gaa aaa ccc tac aat aaa aat gaa gga aac ctg gaa aac gag gga aag      226
Glu Lys Pro Tyr Asn Lys Asn Glu Gly Asn Leu Glu Asn Glu Gly Lys         
            5                   10                  15                  

cca gaa gat gaa gta gag cct gat gat gaa gga aag tca gac gag gaa      274
Pro Glu Asp Glu Val Glu Pro Asp Asp Glu Gly Lys Ser Asp Glu Glu         
        20                  25                  30                      

gaa aag cca gac gtg gag ggg aag aca gaa tgc gag gga aag aga gag      322
Glu Lys Pro Asp Val Glu Gly Lys Thr Glu Cys Glu Gly Lys Arg Glu         
    35                  40                  45                          

gat gag gga gag cca ggt gat gag gga caa ctg gaa gat gag gga agc      370
Asp Glu Gly Glu Pro Gly Asp Glu Gly Gln Leu Glu Asp Glu Gly Ser         
50                  55                  60                  65          

cag gaa aag cag ggc agg tcc gaa ggt gag ggc aag cca caa ggc gag      418
Gln Glu Lys Gln Gly Arg Ser Glu Gly Glu Gly Lys Pro Gln Gly Glu         
                70                  75                  80              

ggc aag cca gcc tcc cag gca aag cca gag agc cag ccg cgg gcc gcc      466
Gly Lys Pro Ala Ser Gln Ala Lys Pro Glu Ser Gln Pro Arg Ala Ala         
            85                  90                  95                  

gaa aag cgc ccg gct gaa gat tat gtg ccc cgg aaa gca aaa aga aaa      514
Glu Lys Arg Pro Ala Glu Asp Tyr Val Pro Arg Lys Ala Lys Arg Lys         
        100                 105                 110                     

acg gac agg ggg acg gac gat tcc ccc aag gac tct cag gag gac tta      562
Thr Asp Arg Gly Thr Asp Asp Ser Pro Lys Asp Ser Gln Glu Asp Leu         
    115                 120                 125                         

cag gaa agg cat ctg agc agt gag gag atg atg aga gaa tgt gga gat      610
Gln Glu Arg His Leu Ser Ser Glu Glu Met Met Arg Glu Cys Gly Asp         
130                 135                 140                 145         

gtg tca agg gct caa gag gag cta agg aaa aaa cag aaa atg ggt ggt      658
Val Ser Arg Ala Gln Glu Glu Leu Arg Lys Lys Gln Lys Met Gly Gly         
                150                 155                 160             

ttt cat tgg atg caa aga gat gta cag gat cca ttc gcc cca agg gga      706
Phe His Trp Met Gln Arg Asp Val Gln Asp Pro Phe Ala Pro Arg Gly         
            165                 170                 175                 

caa cgg ggt gtc agg gga gtg agg ggt gga ggt agg ggc cag agg ggc      754
Gln Arg Gly Val Arg Gly Val Arg Gly Gly Gly Arg Gly Gln Arg Gly         
        180                 185                 190                     

tta cac gat atc cca tac ctt taa tgcctttggc cttccattct gatttctctg     808
Leu His Asp Ile Pro Tyr Leu                                             
    195                 200                                             

atgagaatat tgctggccct gctttccctg gtaggtattt gccaggccca atgctttaac    868

cttaagctga tactttgctt tagatgtcag tctcgttacc agcagccttt tgacccaact    928

acggcgctct atattttagt agaggatttt cacccatgtg catggaaaag atgttcatgg    988

tacattgtaa aaaaataaaa ttaaaattaa aaaaagtttg cagaaccgca aaaaaaaaaa   1048

aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                      1076


<210>  132
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Glu Lys Pro Tyr Asn Lys Asn Glu Gly Asn Leu Glu Asn Glu Gly 
1               5                   10                  15      


Lys Pro Glu Asp Glu Val Glu Pro Asp Asp Glu Gly Lys Ser Asp Glu 
            20                  25                  30          


Glu Glu Lys Pro Asp Val Glu Gly Lys Thr Glu Cys Glu Gly Lys Arg 
        35                  40                  45              


Glu Asp Glu Gly Glu Pro Gly Asp Glu Gly Gln Leu Glu Asp Glu Gly 
    50                  55                  60                  


Ser Gln Glu Lys Gln Gly Arg Ser Glu Gly Glu Gly Lys Pro Gln Gly 
65                  70                  75                  80  


Glu Gly Lys Pro Ala Ser Gln Ala Lys Pro Glu Ser Gln Pro Arg Ala 
                85                  90                  95      


Ala Glu Lys Arg Pro Ala Glu Asp Tyr Val Pro Arg Lys Ala Lys Arg 
            100                 105                 110         


Lys Thr Asp Arg Gly Thr Asp Asp Ser Pro Lys Asp Ser Gln Glu Asp 
        115                 120                 125             


Leu Gln Glu Arg His Leu Ser Ser Glu Glu Met Met Arg Glu Cys Gly 
    130                 135                 140                 


Asp Val Ser Arg Ala Gln Glu Glu Leu Arg Lys Lys Gln Lys Met Gly 
145                 150                 155                 160 


Gly Phe His Trp Met Gln Arg Asp Val Gln Asp Pro Phe Ala Pro Arg 
                165                 170                 175     


Gly Gln Arg Gly Val Arg Gly Val Arg Gly Gly Gly Arg Gly Gln Arg 
            180                 185                 190         


Gly Leu His Asp Ile Pro Tyr Leu 
        195                 200 


<210>  133
<211>  1303
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (25)..(1086)
<223>  

<400>  133
caagagcgcg ggcggcgagg caag atg gcg gca acc aag agg aaa cgg cgt        51
                           Met Ala Ala Thr Lys Arg Lys Arg Arg          
                           1               5                            

gga ggc ttt gca gtt cag gcg aag aag cca aaa aga aac gaa ata gat       99
Gly Gly Phe Ala Val Gln Ala Lys Lys Pro Lys Arg Asn Glu Ile Asp         
10                  15                  20                  25          

gcg gag ccg cca gct aag cgg cac gcc aca gca gag gag gtg gag gaa      147
Ala Glu Pro Pro Ala Lys Arg His Ala Thr Ala Glu Glu Val Glu Glu         
                30                  35                  40              

gaa gag agg gac cgg atc cca ggc ccc gtt tgc aag gga aag tgg aaa      195
Glu Glu Arg Asp Arg Ile Pro Gly Pro Val Cys Lys Gly Lys Trp Lys         
            45                  50                  55                  

aat aag gaa cgg att ctc atc ttt tct tcc aga gga ata aat ttt aga      243
Asn Lys Glu Arg Ile Leu Ile Phe Ser Ser Arg Gly Ile Asn Phe Arg         
        60                  65                  70                      

aca aga cat tta atg cag gac ttg aga atg ttg atg cct cat tct aaa      291
Thr Arg His Leu Met Gln Asp Leu Arg Met Leu Met Pro His Ser Lys         
    75                  80                  85                          

gca gat act aaa atg gat cgt aag gat aag cta ttt gtg att aac gag      339
Ala Asp Thr Lys Met Asp Arg Lys Asp Lys Leu Phe Val Ile Asn Glu         
90                  95                  100                 105         

gtt tgt gaa atg aag aac tgt aat aaa tgc atc tat ttt gaa gct aag      387
Val Cys Glu Met Lys Asn Cys Asn Lys Cys Ile Tyr Phe Glu Ala Lys         
                110                 115                 120             

aaa aaa cag gat ctc tat atg tgg ctt tca aat tca cct cac gga cca      435
Lys Lys Gln Asp Leu Tyr Met Trp Leu Ser Asn Ser Pro His Gly Pro         
            125                 130                 135                 

tct gct aaa ttc ctt gtt caa aat att cat acc ctc gct gaa ctg aag      483
Ser Ala Lys Phe Leu Val Gln Asn Ile His Thr Leu Ala Glu Leu Lys         
        140                 145                 150                     

atg act gga aac tgt ttg aaa ggt tct cgg ccc ctt ttg tct ttt gac      531
Met Thr Gly Asn Cys Leu Lys Gly Ser Arg Pro Leu Leu Ser Phe Asp         
    155                 160                 165                         

cct gct ttt gat gaa tta cca cat tat gct ttg tta aaa gaa ctc tta      579
Pro Ala Phe Asp Glu Leu Pro His Tyr Ala Leu Leu Lys Glu Leu Leu         
170                 175                 180                 185         

att cag atc ttt agt aca cca cgg tat cat ccc aaa agc caa cca ttt      627
Ile Gln Ile Phe Ser Thr Pro Arg Tyr His Pro Lys Ser Gln Pro Phe         
                190                 195                 200             

gtg gac cac gtg ttt act ttc acc att ttg gat aat agg ata tgg ttt      675
Val Asp His Val Phe Thr Phe Thr Ile Leu Asp Asn Arg Ile Trp Phe         
            205                 210                 215                 

cgg aac ttt cag atc ata gaa gaa gat gct gct ctt gta gaa ata gga      723
Arg Asn Phe Gln Ile Ile Glu Glu Asp Ala Ala Leu Val Glu Ile Gly         
        220                 225                 230                     

cct cgt ttt gtc tta aat ctc ata aag att ttc cag gga agt ttt gga      771
Pro Arg Phe Val Leu Asn Leu Ile Lys Ile Phe Gln Gly Ser Phe Gly         
    235                 240                 245                         

gga cca act tta tat gaa aat cct cac tac cag tca cca aac atg cat      819
Gly Pro Thr Leu Tyr Glu Asn Pro His Tyr Gln Ser Pro Asn Met His         
250                 255                 260                 265         

cgg cgt gtc ata aga tcc atc aca gct gca aaa tac aga gag aaa cag      867
Arg Arg Val Ile Arg Ser Ile Thr Ala Ala Lys Tyr Arg Glu Lys Gln         
                270                 275                 280             

caa gtg aaa gat gtg caa aaa ctg aga aag aaa gag ccg aag act ctt      915
Gln Val Lys Asp Val Gln Lys Leu Arg Lys Lys Glu Pro Lys Thr Leu         
            285                 290                 295                 

ctt cca cat gat ccc act gca gat gtt ttt gta aca cca gct gag gag      963
Leu Pro His Asp Pro Thr Ala Asp Val Phe Val Thr Pro Ala Glu Glu         
        300                 305                 310                     

aaa cca ata gaa ata cag tgg gta aaa cca gag cca aaa gtt gat ttg     1011
Lys Pro Ile Glu Ile Gln Trp Val Lys Pro Glu Pro Lys Val Asp Leu         
    315                 320                 325                         

aaa gca aga aag aaa cgg att tac aaa agg caa aga aaa atg aaa cag     1059
Lys Ala Arg Lys Lys Arg Ile Tyr Lys Arg Gln Arg Lys Met Lys Gln         
330                 335                 340                 345         

agg atg gac agt ggg aaa aca aaa taa gtcaatggaa acctgatttg           1106
Arg Met Asp Ser Gly Lys Thr Lys                                         
                350                                                     

tttttcagtt actttatatt tattttgtat tcaatgtgta aatactttta ttatctaata   1166

ctatcttacg tctaattagt gtagcattta caagaaagaa aaattaagat cttaaaatca   1226

gtgattatct ttttctaaat aaaatatcac cagaattcat cagttaaaaa aaaaaaaaaa   1286

aaaaaaaaaa aaaaaaa                                                  1303


<210>  134
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Ala Ala Thr Lys Arg Lys Arg Arg Gly Gly Phe Ala Val Gln Ala 
1               5                   10                  15      


Lys Lys Pro Lys Arg Asn Glu Ile Asp Ala Glu Pro Pro Ala Lys Arg 
            20                  25                  30          


His Ala Thr Ala Glu Glu Val Glu Glu Glu Glu Arg Asp Arg Ile Pro 
        35                  40                  45              


Gly Pro Val Cys Lys Gly Lys Trp Lys Asn Lys Glu Arg Ile Leu Ile 
    50                  55                  60                  


Phe Ser Ser Arg Gly Ile Asn Phe Arg Thr Arg His Leu Met Gln Asp 
65                  70                  75                  80  


Leu Arg Met Leu Met Pro His Ser Lys Ala Asp Thr Lys Met Asp Arg 
                85                  90                  95      


Lys Asp Lys Leu Phe Val Ile Asn Glu Val Cys Glu Met Lys Asn Cys 
            100                 105                 110         


Asn Lys Cys Ile Tyr Phe Glu Ala Lys Lys Lys Gln Asp Leu Tyr Met 
        115                 120                 125             


Trp Leu Ser Asn Ser Pro His Gly Pro Ser Ala Lys Phe Leu Val Gln 
    130                 135                 140                 


Asn Ile His Thr Leu Ala Glu Leu Lys Met Thr Gly Asn Cys Leu Lys 
145                 150                 155                 160 


Gly Ser Arg Pro Leu Leu Ser Phe Asp Pro Ala Phe Asp Glu Leu Pro 
                165                 170                 175     


His Tyr Ala Leu Leu Lys Glu Leu Leu Ile Gln Ile Phe Ser Thr Pro 
            180                 185                 190         


Arg Tyr His Pro Lys Ser Gln Pro Phe Val Asp His Val Phe Thr Phe 
        195                 200                 205             


Thr Ile Leu Asp Asn Arg Ile Trp Phe Arg Asn Phe Gln Ile Ile Glu 
    210                 215                 220                 


Glu Asp Ala Ala Leu Val Glu Ile Gly Pro Arg Phe Val Leu Asn Leu 
225                 230                 235                 240 


Ile Lys Ile Phe Gln Gly Ser Phe Gly Gly Pro Thr Leu Tyr Glu Asn 
                245                 250                 255     


Pro His Tyr Gln Ser Pro Asn Met His Arg Arg Val Ile Arg Ser Ile 
            260                 265                 270         


Thr Ala Ala Lys Tyr Arg Glu Lys Gln Gln Val Lys Asp Val Gln Lys 
        275                 280                 285             


Leu Arg Lys Lys Glu Pro Lys Thr Leu Leu Pro His Asp Pro Thr Ala 
    290                 295                 300                 


Asp Val Phe Val Thr Pro Ala Glu Glu Lys Pro Ile Glu Ile Gln Trp 
305                 310                 315                 320 


Val Lys Pro Glu Pro Lys Val Asp Leu Lys Ala Arg Lys Lys Arg Ile 
                325                 330                 335     


Tyr Lys Arg Gln Arg Lys Met Lys Gln Arg Met Asp Ser Gly Lys Thr 
            340                 345                 350         


Lys 
    


<210>  135
<211>  3125
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (2469)..(2726)
<223>  

<400>  135
actttgtctg ttaaacattt ggaggtttct cccttaacct aataccccgc tgcgtcccag     60

gtatgtttct cagcctgggc aggaattgca tgttttgagt tccattgtga gcagccttac    120

agctctgggc tcccatctta aggattatta aagagttttg gcagttggta tttttctaaa    180

actgatattg accataggga acatacttgg aatttgtttt tttttttaaa tcctaaacct    240

gacagttcct ccttcagagg ggcaaatggg aaactttaag atcacccacg gtatagtact    300

gctagaaagc tgaagggggt cttgggccag atgcctggct tctgttctag ctaaataaga    360

ctcttgaata agtctccagg ggtcccagca ggttctgtgg gatcagttgt agctgggtac    420

ccagactgag gttttaaaaa gactgctttt tcattaagcc agtttgcaac tcattttccc    480

cggttctgga ttgggtagtg gttgactgag ggaaaagcca ggctgctctt ggccagataa    540

ggccctttcc atcccagatc agagtgtatc agagaaagct gcacaaaaga ggcaggcagc    600

ccaggaccct gagtactctg gagaaactag gttccttccc caccctttaa gaagacattc    660

cgtgcattag atgtactaga gtggatgtat tttgttgttt tttaaattaa ctatttagcc    720

tcctcatccc ccaccaaaaa agccatttag ttattttttg gttatattga tccatttgca    780

aatgagaagc cagaaaaggg agcagtcagg gagggactta caagttcctt tcaagtttga    840

gtacttgatg ctcagcaaag atttcaagct tctgcagtag ctctgggcca atgcttgact    900

ctttcatgac cacaagaaat gcagtttttc tgcaaaggga tccaaggtga ggtgtgtgta    960

gggtttgaag ttatacttct gggaagtgaa aagtcttgtt cctttcaacc tagaaatagg   1020

tttgccactt aatgagtgag cagtaagtct gtgtaagagg ctgaatgcat gcccgctcag   1080

ataagccagt acactccttg cttagcaaca gaacatcagg gtgatgtgga gaggggcagg   1140

atgtggacgc cactttggaa atcggcaaca tctgagggca acaacaaaca agtgtgttgg   1200

gaaataagaa ataactcagt tttgacaact ggctttgtca gcttttgtga tgtttcttta   1260

gcagtttatt ggaaagatgg tatgagatga cgtgctgctt cattgaattg ctctttcccc   1320

catctttgcc aaatctcaat gtatcgttct taaccccacc tcctgtaagg ggctttgcta   1380

tgcttcagct ggttgtctca gcagctgaag tgctgcccac ctgtgtgagt tgggtccagg   1440

aaaccatgtc tgcccttctg ataagggaag atgaatctag agctgggtga agatctaaat   1500

tttaaccaaa cccctgggcc caggaaaata acaattgaaa atgtacaagg cagtgttttc   1560

aatattaaac ttccccaagg aaagcacaaa ctagtctttt tggaaaggga gaaaggatta   1620

agccacacag tattagtctt tgaagcagta ctggtctcta ggggctggtg ccaaaatgga   1680

gtcccatagt agttacactc gatggcctca tgtactatat actgtgccaa attgtattaa   1740

acagtggtgg ggagttactg ggataagaac ttgtctaaaa gtttacaaac caaaacagat   1800

ctgttaggtt ggtgcaaaaa ccacaattac ttttacacca acctatgtat ttaagaatgt   1860

ttggtttgcc agattccaaa tgaggtcttc agtgcagcaa agcccaaaag gtgtagactc   1920

agttatgcaa ttataaggtt aaggcgtaga agaaagctgc tgctaggttt ttgttgcatt   1980

ttacttgact gctctgctgt ttttcttgtc tctcatgttt ggttagctat gacttgagca   2040

tcttggtaac tgacaaaggt cttccttggg ggacttgaac atcttggtaa atgacaggtc   2100

ttcttggagg actccagcag tatcttgttt aaacgactga aaggactatt aaggttgttg   2160

aattgtgtta attgggactc attgaggaaa tgcgacattg atcctcctct tattccacag   2220

tgtgttttct gatcatataa agaaggttcc gaaccatcca tccccctcag agtttattcc   2280

cctggtaagc tgtaattgca tatccagttt aaactggact gggactgcat gttggtgagg   2340

atcggcaggg gttttccccc ttttcgaaag atgaaataga ttcttgagca ctggttgcag   2400

aagccaaaat agttcaaata gctttgcata accattgggt tctgcttctg attcaggtgc   2460

tgggcatc atg tcc tcc cta ttc ttc tct tct tgg aaa ccc agc cta tct    2510
         Met Ser Ser Leu Phe Phe Ser Ser Trp Lys Pro Ser Leu Ser        
         1               5                   10                         

cat aaa tac cta ctt ccg cca ccc atc caa cct ccc tgc tcc ttt caa     2558
His Lys Tyr Leu Leu Pro Pro Pro Ile Gln Pro Pro Cys Ser Phe Gln         
15                  20                  25                  30          

cac aaa tct tgg ata ttg cca aag gaa gcc att cag cag ctg ctg ggg     2606
His Lys Ser Trp Ile Leu Pro Lys Glu Ala Ile Gln Gln Leu Leu Gly         
                35                  40                  45              

ttt ttc atc ccc ctg aca tgc ata cat ttg ctc tgg gag aag tgt ctt     2654
Phe Phe Ile Pro Leu Thr Cys Ile His Leu Leu Trp Glu Lys Cys Leu         
            50                  55                  60                  

ccc tct gac cct ggt ccc cag ctc cgt ctg tgc tta att gct ctt acc     2702
Pro Ser Asp Pro Gly Pro Gln Leu Arg Leu Cys Leu Ile Ala Leu Thr         
        65                  70                  75                      

tgt tgc act aat gaa tat gac tag gttttaaagg gggaatgtga agcaataggc    2756
Cys Cys Thr Asn Glu Tyr Asp                                             
    80                  85                                              

acatggggct tagatgaatt ggtcccacag atataccctg ccttaagccg ctgaggtgat   2816

gagtccactg ctcatgtgac cctccacctt tgtggatccc tcttggtttg tgaccagtgt   2876

gtctgtttgt tgaggttgta caaacttgac aaaagttaat acttttgttt gtattttctg   2936

cactgttgca ctctccaaat ggccccttga gtatttttat tgacttgtta cacacatttt   2996

tgtctttgat gtctacattt tttcctttaa tgttttttat ttggaaggtt acctgctgtt   3056

ggatttaata aatttgttta cttgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3116

aaaaaaaaa                                                           3125


<210>  136
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Ser Ser Leu Phe Phe Ser Ser Trp Lys Pro Ser Leu Ser His Lys 
1               5                   10                  15      


Tyr Leu Leu Pro Pro Pro Ile Gln Pro Pro Cys Ser Phe Gln His Lys 
            20                  25                  30          


Ser Trp Ile Leu Pro Lys Glu Ala Ile Gln Gln Leu Leu Gly Phe Phe 
        35                  40                  45              


Ile Pro Leu Thr Cys Ile His Leu Leu Trp Glu Lys Cys Leu Pro Ser 
    50                  55                  60                  


Asp Pro Gly Pro Gln Leu Arg Leu Cys Leu Ile Ala Leu Thr Cys Cys 
65                  70                  75                  80  


Thr Asn Glu Tyr Asp 
                85  


<210>  137
<211>  2551
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (988)..(1275)
<223>  

<400>  137
gtgggactgg agatagaaaa gacagagccc ttgacttcct tattctttaa attccttaag     60

tgggattttt ttttctcctt tctccactca ggacattctc ttttgaaatg acctaatttt    120

ccacacttgt aacatttgtc ttgtccctct cccttttcag tttttggagt cttagggtac    180

tgggtttgct ttcccttttt acctgtcttt gagttctgtg gcccccctgt ctcatatctt    240

ttgtgaggcc tggcaaatgg aggcttaagc ttggcctctg gtgcattctg tcagaaaatt    300

tttctttttg ctttggtttt tcttcatccc tccttacata tactttttga gcttattcta    360

agaattcccg tatagactgt tttttccagt tttctagttt ctgtaacttt ttttgcaatg    420

gcttgctaaa tggctaccaa tggctagcta ttggtaacaa aatgtagctt taacatttct    480

tgcctgctag ggtcttctgg atccaaatgt gcatattttc tcatttgttc tcatagtctt    540

tttagaaagt ttttagggct ttcatctttt ttctgtttta tctaaaatgc tcggggaaga    600

ttctgagcac agggcactga ctcctgaatt cctttaatta tcatttccct tatatctttc    660

atgaattttt agtggactgt gtcgttatcc cattgaggat cttgggtcgg gaatttctgg    720

tctacaatgg gaacgttttg gctggatagg tatttacgtt cccaaactct catagcagtc    780

ctgcaaatca actgccttat atataatact ccaatattac ctgtaaagtt gtcagatgtg    840

tcataccggc tcatacaaga tcttttgtat cattttataa aacgatacaa aagctgcaaa    900

gccaccagcc tgcctgcttc ccttggagaa gttgggactt cctgacaact gcacaaactc    960

acgtggggga tttcaatatc ccaaagc atg cag att cct ggt gtg gct gga att   1014
                              Met Gln Ile Pro Gly Val Ala Gly Ile       
                              1               5                         

ggt gct ggg gtg ctg cga aag cca ggt ttg aag cag gaa gac aaa aaa     1062
Gly Ala Gly Val Leu Arg Lys Pro Gly Leu Lys Gln Glu Asp Lys Lys         
10                  15                  20                  25          

acc act cac ctg tgt cag cct cga gtg ctg aag aac aac cgt gtg tgg     1110
Thr Thr His Leu Cys Gln Pro Arg Val Leu Lys Asn Asn Arg Val Trp         
                30                  35                  40              

gcc ttc aac cct gtc tgg gtg ggt tct gga cag tgg gtg ggg acc cgg     1158
Ala Phe Asn Pro Val Trp Val Gly Ser Gly Gln Trp Val Gly Thr Arg         
            45                  50                  55                  

cgg gag aag gga aag gtc gtt gag ggg gca ggg cat gaa aac tgt cgc     1206
Arg Glu Lys Gly Lys Val Val Glu Gly Ala Gly His Glu Asn Cys Arg         
        60                  65                  70                      

tgg agc tgg gca aga ggg tgg agg ctg ctt tgg aag ctg ggc ctg gtt     1254
Trp Ser Trp Ala Arg Gly Trp Arg Leu Leu Trp Lys Leu Gly Leu Val         
    75                  80                  85                          

aga ggg tgg agg tgg agg tag ggcctggagt ttcaagcttc agccatgcat        1305
Arg Gly Trp Arg Trp Arg                                                 
90                  95                                                  

agactagtca gcttctggtg tgtgactaga acagggcttg ttccctcaag cttcagctgt   1365

gcatagactg gtcagactcc gtagtgacta gagcaggcag tcttctttag cagcaggttg   1425

atctcatctc aggatgagtt ggatgatctg ggtcctgctg gcttgtctac ttgtcttgag   1485

ctgccagttt cagctgactg tggtggatct aaggcacaac acctgcaact ttaacagcag   1545

cgggactgaa caagattaca gtatagggct tatattgtat gagtcttaga gaagttggat   1605

tctacatagc tggtggcctt gtagctgtgt caaaaaaaag aactggctaa atacagacat   1665

ttgtaaaaca tagtcatgct taagagacta gggaaatgag taacagtaga agaatttgtc   1725

tttctctctc tctctctttt ttttttcctt cactttgttc tggaatttaa aaagtgtcta   1785

gagcccatta ctttagcctt agctttttgg acagcgttat cttataactt tccttgaagt   1845

gagctgctaa gcagaagaaa acttgtttct ttttcttttt aacctttacc acaattctgt   1905

gggccaaagg gatcaggaga cagacataga gcagtagaaa acctgagaca gagaaaagaa   1965

gaatgagaga gactcataac agatggtaaa gtagaggagg ggtgagggat ttgccaagag   2025

gtgacaaaag tgaaaaaaaa aaaagataag aaagcaggag gagaaaagca actggagaaa   2085

tgtagagaaa agctagatgt acagagagat gaagaacagc aaggcaggaa gaggggcagc   2145

aaaaagggag gctcatcaga gtgagggaga ggaggaggga tttgcagcca ggacagacag   2205

agcagagtgg tgctggtggc aaggagaaca gaggaagaac aacagcaggg aacacagctg   2265

ggaatctagg gtgccagaga gtgggtacag aggggtataa cagggaagag ataatttaac   2325

agggagaaaa gaggaggtgc agagatggga gaagaggtgg aaatatatgg agattgagga   2385

tgattgaaag actggggaga aggaggaaca agaggttata taagttccaa ggatgaagca   2445

gaagaggtgg aagagaagga atagaggtaa gaagggaata aacagcagca gaagagaggg   2505

gtacagaatg aggtgcagaa tcccagggaa aaaaaaaaaa aaaaaa                  2551


<210>  138
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Gln Ile Pro Gly Val Ala Gly Ile Gly Ala Gly Val Leu Arg Lys 
1               5                   10                  15      


Pro Gly Leu Lys Gln Glu Asp Lys Lys Thr Thr His Leu Cys Gln Pro 
            20                  25                  30          


Arg Val Leu Lys Asn Asn Arg Val Trp Ala Phe Asn Pro Val Trp Val 
        35                  40                  45              


Gly Ser Gly Gln Trp Val Gly Thr Arg Arg Glu Lys Gly Lys Val Val 
    50                  55                  60                  


Glu Gly Ala Gly His Glu Asn Cys Arg Trp Ser Trp Ala Arg Gly Trp 
65                  70                  75                  80  


Arg Leu Leu Trp Lys Leu Gly Leu Val Arg Gly Trp Arg Trp Arg 
                85                  90                  95  


<210>  139
<211>  2971
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (2187)..(2453)
<223>  

<400>  139
ccggcacgcc ttgctggttg ttatattttt agtaaaaaca gggtttcacc gtgttggcca     60

ggctggtctc gaactcctga cctcaagtta tctgcccgcc tcagcctccc aaagtgctgg    120

gattgcaggt gtgagtcact gtgcccggcc gacttcctgt atttttaaag ctagtctcag    180

tttggttttt ctatcacttg ctgcaagtga aaacttcgcg gatgacacag aatctgttat    240

accctgaatt ctgtatgtca cttccccatc agctgttttg atctaggtgg actcttgttt    300

ctgtggaaat cgaagtcacc tttatgaaaa ttgagcactt tggggccatt gtgtggtcac    360

ataatttctt taaaatgtgt tcagttttat aggaaaacat tgtttgatat ttatataagt    420

taaagagatt attcagctca tgaaaggcac aaaggtagaa gatttataga aaaataaaat    480

atgcttatgg tggaaggtcc aactgtacaa aagttggatg atttgtaagt tctccctggt    540

agattttctg agatctaata ttccagaatt gtgtttagta ttaaatttca atattatgat    600

attggacttg taccactgta aggctaggaa attataaaac cagttcacat tgaacataac    660

aaaaggaaaa gctgcaagct gtttttgtta agtgattcac attgatctct ttcccaccca    720

ggttccaagc caatccagac atagacaaga tgtggaagag ggagcatggg atattgcatt    780

tattaatgat aaagctaaaa ttagataatg aggcttatat aggtgtaaaa gtaggttccc    840

ttataccaag ccccagaatc atatacccat ctaaccacag acaacactga actaagacta    900

ttatatggcc tgatcttgtt aaagttacag caaggaggaa tggggcagaa tgcattttct    960

ctgtaagcag cttatttcca aagagagagg agggaaagaa agtgttactc acgctcactt   1020

ccctatccca aacttaacaa tcaagtcaat tacatctgtc aatctaggtc caaccaggag   1080

acagaacaca ccgtaattta aataggctaa gtttaaagga ttatgatgct gtgatagaac   1140

aatataaata tgtttagaga atctaaacta ttctagggct gagggtgagt agccaaagca   1200

ggacaaagtt ggaagagagt ccccctctgg tgttcagact ttattggaga agttgtggct   1260

gcacgacact ggatgatgtg gaagtttgct ggcgtgcctc gggccagagc tggtttagaa   1320

ttgtctgata aacaggaaac ggtcctctgg gacacaggca agccaaggct agtgagcaga   1380

ttgcagagag agttaggaca tttctgcagg tgtgaaactg gggcagaact tatacacatt   1440

ggaaggacct cagaagccaa cctttaggag aaaggaaagc tgagattgac aggtgggcat   1500

acagagggag tcagggcact gctacaggta caaggccagg agcatgtggg gtgcatctca   1560

agagggctgc agcaaggtgg tcaccaggct tcctaggctg ggactgcaag gtggactgta   1620

cattctgtgt gcagccggag caaaacacca ccagatgcat acaccactaa ccttgtgtgg   1680

gagcaaaaaa gaaaaaaaaa tgagcacacc aacactagga tgagaaattc ctttcctcct   1740

gcagtgcccc tccaatgtcc tctacttatt ctcattttaa aggataaatg cttattgttc   1800

aatctgttat cacagagtag atactgaagg atgagtttgg agctgagaag tgataaattg   1860

acaagggggt tcagtcagcc cctttgactg ctcagcttcc atacgcacct ttctacacgt   1920

gtttgaactc ctgcacaaca gagcaactaa ctgtattttg gtctagcaag atacggttat   1980

cctgataact gaagctcttg ctgttcccca aaataagaca caaagtttca acagtcattg   2040

gattcattgc tggctgtatt aattactcct caattcagtc atcatgccac ctaattttct   2100

gttaagactg aattgtaaag ttgaccttca gcaacctgta taataaaaat agggagaatg   2160

gcaaagtaga aaataaaaat aaacac atg ctt gca agc aaa gag aaa ata tgc    2213
                             Met Leu Ala Ser Lys Glu Lys Ile Cys        
                             1               5                          

aga gct att aca gtt ctt ggt ttt gta atg gtc aca aag tta tgg ttg     2261
Arg Ala Ile Thr Val Leu Gly Phe Val Met Val Thr Lys Leu Trp Leu         
10                  15                  20                  25          

ata tct ata gct tcc acc tcc aac tac ctc tat att tcc ctt tcc cag     2309
Ile Ser Ile Ala Ser Thr Ser Asn Tyr Leu Tyr Ile Ser Leu Ser Gln         
                30                  35                  40              

tca gaa tca gct gct ctg ggt tct ttg cct ggt aga gtg ctt caa acc     2357
Ser Glu Ser Ala Ala Leu Gly Ser Leu Pro Gly Arg Val Leu Gln Thr         
            45                  50                  55                  

ttc ctt ttt gaa agg tct gaa tcc tca atc atc ctg ccc ttt tct gat     2405
Phe Leu Phe Glu Arg Ser Glu Ser Ser Ile Ile Leu Pro Phe Ser Asp         
        60                  65                  70                      

tct tgt ggt ttt cca ttg aac ctt tac agt tgg aca tgg aag tat taa     2453
Ser Cys Gly Phe Pro Leu Asn Leu Tyr Ser Trp Thr Trp Lys Tyr             
    75                  80                  85                          

gaggcacttt agaaaaatct cctgggtacc agaaagtcct ccttgcttcc atttgcagaa   2513

gcaaaccaat ttaccttgga aattcagatc aatcactaca gccaataaat taaccccctg   2573

tttttcatcc gttggttaag tgttacaaga agtgcaaaat gaccaggtgg cagtctgata   2633

agcagaattc tgagatgaat gtcgtgactt tccctctctt gtacacaccc tgtgtaatct   2693

ccccttgagc atggttgaaa cctgtaaata taattggata gcacctccac gattatgcta   2753

tatggcaaag ggttcctaat cagttgacta taatccaaag ggagattatc ctgcgtagat   2813

atgatctaat taggcaagtt atttaaaagc agaagagtta tcctgctggt ctagaagaaa   2873

aacagcctgt tgtgaaagta gggaccacag ggacctgagg gtgacctcca ggagctgaga   2933

gcagtcctca gctaacagta aaaaaaaaaa aaaaaaaa                           2971


<210>  140
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Leu Ala Ser Lys Glu Lys Ile Cys Arg Ala Ile Thr Val Leu Gly 
1               5                   10                  15      


Phe Val Met Val Thr Lys Leu Trp Leu Ile Ser Ile Ala Ser Thr Ser 
            20                  25                  30          


Asn Tyr Leu Tyr Ile Ser Leu Ser Gln Ser Glu Ser Ala Ala Leu Gly 
        35                  40                  45              


Ser Leu Pro Gly Arg Val Leu Gln Thr Phe Leu Phe Glu Arg Ser Glu 
    50                  55                  60                  


Ser Ser Ile Ile Leu Pro Phe Ser Asp Ser Cys Gly Phe Pro Leu Asn 
65                  70                  75                  80  


Leu Tyr Ser Trp Thr Trp Lys Tyr 
                85              


<210>  141
<211>  732
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (74)..(445)
<223>  

<400>  141
caaatccaga aaagatccgt tttcctaacc ttgttcgcct attttattat ttaaattgca     60

gcaggaggga agc atg tct act tta tcc aat ttc aca cag acg ctg gaa       109
               Met Ser Thr Leu Ser Asn Phe Thr Gln Thr Leu Glu          
               1               5                   10                   

gac gtc ttc cga agg att ttt att act tat atg gac aat tgg cgc cag      157
Asp Val Phe Arg Arg Ile Phe Ile Thr Tyr Met Asp Asn Trp Arg Gln         
        15                  20                  25                      

aac aca aca gct gag caa gag gcc ctc caa gcc aaa gtt gat gct gag      205
Asn Thr Thr Ala Glu Gln Glu Ala Leu Gln Ala Lys Val Asp Ala Glu         
    30                  35                  40                          

aac ttc tac tat gtc atc ctg tac ctc atg gtg atg att gga atg ttc      253
Asn Phe Tyr Tyr Val Ile Leu Tyr Leu Met Val Met Ile Gly Met Phe         
45                  50                  55                  60          

tct ttc atc atc gtg gcc atc ctg gtg agc act gtg aaa tcc aag aga      301
Ser Phe Ile Ile Val Ala Ile Leu Val Ser Thr Val Lys Ser Lys Arg         
                65                  70                  75              

cgg gaa cac tcc aat gac ccc tac cac cag tac att gta gag gac tgg      349
Arg Glu His Ser Asn Asp Pro Tyr His Gln Tyr Ile Val Glu Asp Trp         
            80                  85                  90                  

cag gaa aag tac aag agc caa atc ttg aat cta gaa gaa tcg aag gcc      397
Gln Glu Lys Tyr Lys Ser Gln Ile Leu Asn Leu Glu Glu Ser Lys Ala         
        95                  100                 105                     

acc atc cat gag aac att ggt gcg gct ggg ttc aaa atg tcc ccc tga      445
Thr Ile His Glu Asn Ile Gly Ala Ala Gly Phe Lys Met Ser Pro             
    110                 115                 120                         

taagggagaa aggcaccaag ctaacatctg acgtccagac atgaagagat gccagtgcca    505

cgaggcaaat ccaaattgtc tttgcttaga agaaagtgag ttccttgctc tttgttgaga    565

attttcatgg agattatgtg gttggccaat aaagatagat gacatttcaa tctcagtgat    625

ttatgcttgc ttgttggagc aatattttgt gctgaagacc tcttttactt tccgggcaag    685

tgaatgtcat tttaatcaat atcaatgatg aaaataaagc caaattt                  732


<210>  142
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Ser Thr Leu Ser Asn Phe Thr Gln Thr Leu Glu Asp Val Phe Arg 
1               5                   10                  15      


Arg Ile Phe Ile Thr Tyr Met Asp Asn Trp Arg Gln Asn Thr Thr Ala 
            20                  25                  30          


Glu Gln Glu Ala Leu Gln Ala Lys Val Asp Ala Glu Asn Phe Tyr Tyr 
        35                  40                  45              


Val Ile Leu Tyr Leu Met Val Met Ile Gly Met Phe Ser Phe Ile Ile 
    50                  55                  60                  


Val Ala Ile Leu Val Ser Thr Val Lys Ser Lys Arg Arg Glu His Ser 
65                  70                  75                  80  


Asn Asp Pro Tyr His Gln Tyr Ile Val Glu Asp Trp Gln Glu Lys Tyr 
                85                  90                  95      


Lys Ser Gln Ile Leu Asn Leu Glu Glu Ser Lys Ala Thr Ile His Glu 
            100                 105                 110         


Asn Ile Gly Ala Ala Gly Phe Lys Met Ser Pro 
        115                 120             


<210>  143
<211>  2590
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (77)..(2326)
<223>  

<400>  143
aacgcctcgc tcttgagacc agccaccaaa ccacgaaaag tgactttctt ctcgtgtgct     60

ctctacggcc cttctg atg gaa gca gaa aca ggg agc agc gtg gag act gga    112
                  Met Glu Ala Glu Thr Gly Ser Ser Val Glu Thr Gly       
                  1               5                   10                

aag aag gcc aac aga ggc act cga att gcc ctg gtc gtg ttt gtc ggt      160
Lys Lys Ala Asn Arg Gly Thr Arg Ile Ala Leu Val Val Phe Val Gly         
        15                  20                  25                      

ggc acc cta gtt ctg ggc acg atc ctc ttt cta gtg agt caa ggt ctc      208
Gly Thr Leu Val Leu Gly Thr Ile Leu Phe Leu Val Ser Gln Gly Leu         
    30                  35                  40                          

tta agt ctc caa gct aaa cag gag tac tgc ctg aag cca gaa tgc atc      256
Leu Ser Leu Gln Ala Lys Gln Glu Tyr Cys Leu Lys Pro Glu Cys Ile         
45                  50                  55                  60          

gaa gcg gct gct gcc atc tta agt aaa gta aat ctg tct gtg gat cct      304
Glu Ala Ala Ala Ala Ile Leu Ser Lys Val Asn Leu Ser Val Asp Pro         
                65                  70                  75              

tgt gat aat ttc ttc cgg ttc gct tgt gat ggc tgg ata agc aat aat      352
Cys Asp Asn Phe Phe Arg Phe Ala Cys Asp Gly Trp Ile Ser Asn Asn         
            80                  85                  90                  

cca att ccc gaa gat atg cca agc tat ggg gtt tat cct tgg ctg aga      400
Pro Ile Pro Glu Asp Met Pro Ser Tyr Gly Val Tyr Pro Trp Leu Arg         
        95                  100                 105                     

cat aat gtt gac ctc aag ttg aag gaa ctt ttg gag aaa tca atc agt      448
His Asn Val Asp Leu Lys Leu Lys Glu Leu Leu Glu Lys Ser Ile Ser         
    110                 115                 120                         

aga agg cgg gac acc gaa gcc ata cag aaa gcc aaa atc ctt tat tca      496
Arg Arg Arg Asp Thr Glu Ala Ile Gln Lys Ala Lys Ile Leu Tyr Ser         
125                 130                 135                 140         

tcc tgc atg aat gag aaa gcg att gaa aaa gca gat gcc aag cca ctg      544
Ser Cys Met Asn Glu Lys Ala Ile Glu Lys Ala Asp Ala Lys Pro Leu         
                145                 150                 155             

cta cac atc cta cgg cat tca cct ttc cgc tgg ccc gtg ctt gaa tct      592
Leu His Ile Leu Arg His Ser Pro Phe Arg Trp Pro Val Leu Glu Ser         
            160                 165                 170                 

aat att ggc cct gaa ggg gtt tgg tca gag aga aag ttc agc ctt ctg      640
Asn Ile Gly Pro Glu Gly Val Trp Ser Glu Arg Lys Phe Ser Leu Leu         
        175                 180                 185                     

cag aca ctt gca acg ttt cgt ggt caa tac agc aat tct gtg ttc atc      688
Gln Thr Leu Ala Thr Phe Arg Gly Gln Tyr Ser Asn Ser Val Phe Ile         
    190                 195                 200                         

cgt ttg tat gtg tcc cct gat gac aaa gca tcc aat gaa cat atc ttg      736
Arg Leu Tyr Val Ser Pro Asp Asp Lys Ala Ser Asn Glu His Ile Leu         
205                 210                 215                 220         

aag ctg gac caa gca aca ctc tcc ctg gcc gtg agg gaa gac tac ctt      784
Lys Leu Asp Gln Ala Thr Leu Ser Leu Ala Val Arg Glu Asp Tyr Leu         
                225                 230                 235             

gat aac agt aca gaa gcc aag tct tat cgg gat gcc ctt tac aag ttc      832
Asp Asn Ser Thr Glu Ala Lys Ser Tyr Arg Asp Ala Leu Tyr Lys Phe         
            240                 245                 250                 

atg gtg gat act gcc gtg ctt tta gga gct aac agt tcc aga gca gag      880
Met Val Asp Thr Ala Val Leu Leu Gly Ala Asn Ser Ser Arg Ala Glu         
        255                 260                 265                     

cat gac atg aag tca gtg ctc aga ttg gaa att aag ata gct gag ata      928
His Asp Met Lys Ser Val Leu Arg Leu Glu Ile Lys Ile Ala Glu Ile         
    270                 275                 280                         

atg att cca cat gaa aac cga acc agc gag gcc atg tac aac aaa atg      976
Met Ile Pro His Glu Asn Arg Thr Ser Glu Ala Met Tyr Asn Lys Met         
285                 290                 295                 300         

aac att tct gaa ctg agt gct atg att ccc cag ttc gac tgg ctg ggc     1024
Asn Ile Ser Glu Leu Ser Ala Met Ile Pro Gln Phe Asp Trp Leu Gly         
                305                 310                 315             

tac atc aag aag gtc att gac acc aga ctc tac ccc cat ctg aaa gac     1072
Tyr Ile Lys Lys Val Ile Asp Thr Arg Leu Tyr Pro His Leu Lys Asp         
            320                 325                 330                 

atc agc ccc tcc gag aat gtg gtg gtc cgc gtc ccg cag tac ttt aaa     1120
Ile Ser Pro Ser Glu Asn Val Val Val Arg Val Pro Gln Tyr Phe Lys         
        335                 340                 345                     

gat ttg ttt agg ata tta ggg tct gag aga aag aag acc att gcc aac     1168
Asp Leu Phe Arg Ile Leu Gly Ser Glu Arg Lys Lys Thr Ile Ala Asn         
    350                 355                 360                         

tat ttg gtg tgg aga atg gtt tat tcc aga att cca aac ctt agc agg     1216
Tyr Leu Val Trp Arg Met Val Tyr Ser Arg Ile Pro Asn Leu Ser Arg         
365                 370                 375                 380         

cgc ttt cag tat aga tgg ctg gaa ttc tca agg gta atc cag ggg acc     1264
Arg Phe Gln Tyr Arg Trp Leu Glu Phe Ser Arg Val Ile Gln Gly Thr         
                385                 390                 395             

aca act ttg ctg cct caa tgg gac aaa tgt gta aac ttt att gaa agt     1312
Thr Thr Leu Leu Pro Gln Trp Asp Lys Cys Val Asn Phe Ile Glu Ser         
            400                 405                 410                 

gcc ctc cct tat gtt gtt gga aag atg ttt gta gat gtg tac ttc cag     1360
Ala Leu Pro Tyr Val Val Gly Lys Met Phe Val Asp Val Tyr Phe Gln         
        415                 420                 425                     

gaa gat aag aag gaa atg atg gag gaa ttg gtt gag ggc gtt cgc tgg     1408
Glu Asp Lys Lys Glu Met Met Glu Glu Leu Val Glu Gly Val Arg Trp         
    430                 435                 440                         

gcc ttt att gac atg cta gag aaa gaa aat gag tgg atg gat gca gga     1456
Ala Phe Ile Asp Met Leu Glu Lys Glu Asn Glu Trp Met Asp Ala Gly         
445                 450                 455                 460         

acg aaa agg aaa gcc aaa gaa aag gcg aga gct gtt ttg gca aaa gtt     1504
Thr Lys Arg Lys Ala Lys Glu Lys Ala Arg Ala Val Leu Ala Lys Val         
                465                 470                 475             

ggc tat cca gag ttt ata atg aat gat act cat gtt aat gaa gac ctc     1552
Gly Tyr Pro Glu Phe Ile Met Asn Asp Thr His Val Asn Glu Asp Leu         
            480                 485                 490                 

aaa gct atc aag ttt tca gaa gcc gac tac ttt ggc aac gtc cta caa     1600
Lys Ala Ile Lys Phe Ser Glu Ala Asp Tyr Phe Gly Asn Val Leu Gln         
        495                 500                 505                     

act cgc aag tat tta gca cag tct gat ttc ttc tgg cta aga aaa gcc     1648
Thr Arg Lys Tyr Leu Ala Gln Ser Asp Phe Phe Trp Leu Arg Lys Ala         
    510                 515                 520                         

gtt cca aaa aca gag tgg ttt aca aat ccg acg act gtc aat gcc ttc     1696
Val Pro Lys Thr Glu Trp Phe Thr Asn Pro Thr Thr Val Asn Ala Phe         
525                 530                 535                 540         

tac agt gca tcc acc aac cag atc cga ttt cca gca gga gag ctc cag     1744
Tyr Ser Ala Ser Thr Asn Gln Ile Arg Phe Pro Ala Gly Glu Leu Gln         
                545                 550                 555             

aag cct ttc ttt tgg gga aca gaa tat cct cga tct ctg agt tat ggt     1792
Lys Pro Phe Phe Trp Gly Thr Glu Tyr Pro Arg Ser Leu Ser Tyr Gly         
            560                 565                 570                 

gct ata gga gta att gtc gga cat gaa ttt aca cat gga ttt gat aat     1840
Ala Ile Gly Val Ile Val Gly His Glu Phe Thr His Gly Phe Asp Asn         
        575                 580                 585                     

aat ggt aga aaa tat gat aaa aat gga aac ctg gat cct tgg tgg tct     1888
Asn Gly Arg Lys Tyr Asp Lys Asn Gly Asn Leu Asp Pro Trp Trp Ser         
    590                 595                 600                         

act gaa tca gaa gaa aag ttt aag gaa aaa aca aaa tgc atg att aac     1936
Thr Glu Ser Glu Glu Lys Phe Lys Glu Lys Thr Lys Cys Met Ile Asn         
605                 610                 615                 620         

cag tat agc aac tat tat tgg aag aaa gct ggc tta aat gtc aag ggg     1984
Gln Tyr Ser Asn Tyr Tyr Trp Lys Lys Ala Gly Leu Asn Val Lys Gly         
                625                 630                 635             

aag agg acc ctg gga gaa aat att gct gat aat gga ggc ctg cgg gaa     2032
Lys Arg Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Arg Glu         
            640                 645                 650                 

gct ttt agg gct tac agg aaa tgg ata aat gac aga agg cag gga ctt     2080
Ala Phe Arg Ala Tyr Arg Lys Trp Ile Asn Asp Arg Arg Gln Gly Leu         
        655                 660                 665                     

gag gag cct ctt cta cca ggc atc aca ttc acc aac aac cag ctc ttc     2128
Glu Glu Pro Leu Leu Pro Gly Ile Thr Phe Thr Asn Asn Gln Leu Phe         
    670                 675                 680                         

ttc ctg agt tat gct cat gtg agg tgc aat tcc tac aga cca gaa gct     2176
Phe Leu Ser Tyr Ala His Val Arg Cys Asn Ser Tyr Arg Pro Glu Ala         
685                 690                 695                 700         

gcc cga gaa caa gtc caa att ggt gct cac agt ccc cct cag ttt agg     2224
Ala Arg Glu Gln Val Gln Ile Gly Ala His Ser Pro Pro Gln Phe Arg         
                705                 710                 715             

gtc aat ggt gca att agt aac ttt gaa gaa ttc cag aaa gct ttt aac     2272
Val Asn Gly Ala Ile Ser Asn Phe Glu Glu Phe Gln Lys Ala Phe Asn         
            720                 725                 730                 

tgt cca ccc aat tcc acg atg aac aga ggc atg gac tcc tgc cga ctc     2320
Cys Pro Pro Asn Ser Thr Met Asn Arg Gly Met Asp Ser Cys Arg Leu         
        735                 740                 745                     

tgg tag ctgggacgct ggtttatggc atcctgagac agttgcacag tgccagcgga      2376
Trp                                                                     
                                                                        

ggctgcactg agccttcatc gcccattgct ttaggcctgg agactttcat ttttagtgca   2436

ttttcattat ttgggtaggt gacctgcttg gatctagaca gcatctgttc aaagtcgtag   2496

ggcttataaa gtggaatata agaatgaact aagtatgttt ctttagaaaa tcaaaccaac   2556

aaaaataaat ccctaggcta cttttgttaa aaaa                               2590


<210>  144
<211>  749
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Glu Ala Glu Thr Gly Ser Ser Val Glu Thr Gly Lys Lys Ala Asn 
1               5                   10                  15      


Arg Gly Thr Arg Ile Ala Leu Val Val Phe Val Gly Gly Thr Leu Val 
            20                  25                  30          


Leu Gly Thr Ile Leu Phe Leu Val Ser Gln Gly Leu Leu Ser Leu Gln 
        35                  40                  45              


Ala Lys Gln Glu Tyr Cys Leu Lys Pro Glu Cys Ile Glu Ala Ala Ala 
    50                  55                  60                  


Ala Ile Leu Ser Lys Val Asn Leu Ser Val Asp Pro Cys Asp Asn Phe 
65                  70                  75                  80  


Phe Arg Phe Ala Cys Asp Gly Trp Ile Ser Asn Asn Pro Ile Pro Glu 
                85                  90                  95      


Asp Met Pro Ser Tyr Gly Val Tyr Pro Trp Leu Arg His Asn Val Asp 
            100                 105                 110         


Leu Lys Leu Lys Glu Leu Leu Glu Lys Ser Ile Ser Arg Arg Arg Asp 
        115                 120                 125             


Thr Glu Ala Ile Gln Lys Ala Lys Ile Leu Tyr Ser Ser Cys Met Asn 
    130                 135                 140                 


Glu Lys Ala Ile Glu Lys Ala Asp Ala Lys Pro Leu Leu His Ile Leu 
145                 150                 155                 160 


Arg His Ser Pro Phe Arg Trp Pro Val Leu Glu Ser Asn Ile Gly Pro 
                165                 170                 175     


Glu Gly Val Trp Ser Glu Arg Lys Phe Ser Leu Leu Gln Thr Leu Ala 
            180                 185                 190         


Thr Phe Arg Gly Gln Tyr Ser Asn Ser Val Phe Ile Arg Leu Tyr Val 
        195                 200                 205             


Ser Pro Asp Asp Lys Ala Ser Asn Glu His Ile Leu Lys Leu Asp Gln 
    210                 215                 220                 


Ala Thr Leu Ser Leu Ala Val Arg Glu Asp Tyr Leu Asp Asn Ser Thr 
225                 230                 235                 240 


Glu Ala Lys Ser Tyr Arg Asp Ala Leu Tyr Lys Phe Met Val Asp Thr 
                245                 250                 255     


Ala Val Leu Leu Gly Ala Asn Ser Ser Arg Ala Glu His Asp Met Lys 
            260                 265                 270         


Ser Val Leu Arg Leu Glu Ile Lys Ile Ala Glu Ile Met Ile Pro His 
        275                 280                 285             


Glu Asn Arg Thr Ser Glu Ala Met Tyr Asn Lys Met Asn Ile Ser Glu 
    290                 295                 300                 


Leu Ser Ala Met Ile Pro Gln Phe Asp Trp Leu Gly Tyr Ile Lys Lys 
305                 310                 315                 320 


Val Ile Asp Thr Arg Leu Tyr Pro His Leu Lys Asp Ile Ser Pro Ser 
                325                 330                 335     


Glu Asn Val Val Val Arg Val Pro Gln Tyr Phe Lys Asp Leu Phe Arg 
            340                 345                 350         


Ile Leu Gly Ser Glu Arg Lys Lys Thr Ile Ala Asn Tyr Leu Val Trp 
        355                 360                 365             


Arg Met Val Tyr Ser Arg Ile Pro Asn Leu Ser Arg Arg Phe Gln Tyr 
    370                 375                 380                 


Arg Trp Leu Glu Phe Ser Arg Val Ile Gln Gly Thr Thr Thr Leu Leu 
385                 390                 395                 400 


Pro Gln Trp Asp Lys Cys Val Asn Phe Ile Glu Ser Ala Leu Pro Tyr 
                405                 410                 415     


Val Val Gly Lys Met Phe Val Asp Val Tyr Phe Gln Glu Asp Lys Lys 
            420                 425                 430         


Glu Met Met Glu Glu Leu Val Glu Gly Val Arg Trp Ala Phe Ile Asp 
        435                 440                 445             


Met Leu Glu Lys Glu Asn Glu Trp Met Asp Ala Gly Thr Lys Arg Lys 
    450                 455                 460                 


Ala Lys Glu Lys Ala Arg Ala Val Leu Ala Lys Val Gly Tyr Pro Glu 
465                 470                 475                 480 


Phe Ile Met Asn Asp Thr His Val Asn Glu Asp Leu Lys Ala Ile Lys 
                485                 490                 495     


Phe Ser Glu Ala Asp Tyr Phe Gly Asn Val Leu Gln Thr Arg Lys Tyr 
            500                 505                 510         


Leu Ala Gln Ser Asp Phe Phe Trp Leu Arg Lys Ala Val Pro Lys Thr 
        515                 520                 525             


Glu Trp Phe Thr Asn Pro Thr Thr Val Asn Ala Phe Tyr Ser Ala Ser 
    530                 535                 540                 


Thr Asn Gln Ile Arg Phe Pro Ala Gly Glu Leu Gln Lys Pro Phe Phe 
545                 550                 555                 560 


Trp Gly Thr Glu Tyr Pro Arg Ser Leu Ser Tyr Gly Ala Ile Gly Val 
                565                 570                 575     


Ile Val Gly His Glu Phe Thr His Gly Phe Asp Asn Asn Gly Arg Lys 
            580                 585                 590         


Tyr Asp Lys Asn Gly Asn Leu Asp Pro Trp Trp Ser Thr Glu Ser Glu 
        595                 600                 605             


Glu Lys Phe Lys Glu Lys Thr Lys Cys Met Ile Asn Gln Tyr Ser Asn 
    610                 615                 620                 


Tyr Tyr Trp Lys Lys Ala Gly Leu Asn Val Lys Gly Lys Arg Thr Leu 
625                 630                 635                 640 


Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Arg Glu Ala Phe Arg Ala 
                645                 650                 655     


Tyr Arg Lys Trp Ile Asn Asp Arg Arg Gln Gly Leu Glu Glu Pro Leu 
            660                 665                 670         


Leu Pro Gly Ile Thr Phe Thr Asn Asn Gln Leu Phe Phe Leu Ser Tyr 
        675                 680                 685             


Ala His Val Arg Cys Asn Ser Tyr Arg Pro Glu Ala Ala Arg Glu Gln 
    690                 695                 700                 


Val Gln Ile Gly Ala His Ser Pro Pro Gln Phe Arg Val Asn Gly Ala 
705                 710                 715                 720 


Ile Ser Asn Phe Glu Glu Phe Gln Lys Ala Phe Asn Cys Pro Pro Asn 
                725                 730                 735     


Ser Thr Met Asn Arg Gly Met Asp Ser Cys Arg Leu Trp 
            740                 745                 


<210>  145
<211>  1440
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (114)..(476)
<223>  

<400>  145
cggctgagtg gcacttaagc gggccatgcc atgcaacctt gggcgctgcc aaccgtgggc     60

gagctctggg tgtgcgggcg gcctggcgcg gcgctccgct gtgtcagcgt gtt atg       116
                                                           Met          
                                                           1            

atg ccg tcc cgt acc aac ctg gct act gga atc ccc agt agt aaa gtg      164
Met Pro Ser Arg Thr Asn Leu Ala Thr Gly Ile Pro Ser Ser Lys Val         
            5                   10                  15                  

aaa tat tca agg ctc tcc agc aca gac gat ggc tac att gac ctt cag      212
Lys Tyr Ser Arg Leu Ser Ser Thr Asp Asp Gly Tyr Ile Asp Leu Gln         
        20                  25                  30                      

ttt aag aaa acc cct cct aag atc cct tat aag gcc atc gca ctt gcc      260
Phe Lys Lys Thr Pro Pro Lys Ile Pro Tyr Lys Ala Ile Ala Leu Ala         
    35                  40                  45                          

act gtg ctg ttt ttg att ggc gcc ttt ctc att att ata ggc tcc ctc      308
Thr Val Leu Phe Leu Ile Gly Ala Phe Leu Ile Ile Ile Gly Ser Leu         
50                  55                  60                  65          

ctg ctg tca ggc tac atc agc aaa ggg ggg gca gac cgg gcc gtt cca      356
Leu Leu Ser Gly Tyr Ile Ser Lys Gly Gly Ala Asp Arg Ala Val Pro         
                70                  75                  80              

gtg ctg atc att ggc att ctg gtg ttc cta ccc gga ttt tac cac ctg      404
Val Leu Ile Ile Gly Ile Leu Val Phe Leu Pro Gly Phe Tyr His Leu         
            85                  90                  95                  

cgc atc gct tac tat gca tcc aaa ggc tac cgt gct tac tcc tat gat      452
Arg Ile Ala Tyr Tyr Ala Ser Lys Gly Tyr Arg Ala Tyr Ser Tyr Asp         
        100                 105                 110                     

gac att cca gac ttt gat gac tag cacccacccc atagctgagg aggagtcaca     506
Asp Ile Pro Asp Phe Asp Asp                                             
    115                 120                                             

gtggaactgt cccagcttta agatatctag cagaaactat agctgaggac taaggaattc    566

tgcagcttgc agatgtttaa gaaaataatg gccagatttt tttgggtcct tcccaaagat    626

gttaagtgaa cctacagtta gctaattagg acaagctcta tttttcagcc ctgggccctg    686

acaagttttt ccacaggaat atgtatcatg gaagaataga ggttattctg taatggaaaa    746

gtgttgcctg ccaccaccct ctgtagagct gagcatttct tttaaatagt cttcattgcc    806

aatttgttct tgtagcaaat ggaacaatgt ggtatggcta atttcttatt attaagtaat    866

ttattttaaa aatatctgag tatattatcc tgtacactta tccctacctt catgttccag    926

tggaagacct tagtaaaatc aaagatcagt gagttcatct gtaatatttt ttttacttgc    986

tttcttactg acagcaacca ggaatttttt tatcctgcag agcaagtttt caaaatgtaa   1046

atacttcctc tgtttaacag tccttggacc attctgatcc agttcaccag taggttggac   1106

agcatataat ttgcatcatt ttgtcccttg taaatcaaga tgttctgcag attattcctt   1166

taacggccgg acttttggct gtttcctaat gaaacatgta gtggttatta tttagagttt   1226

atagccgtat tgctagcacc ttgtagtatg tcatcattct gctcatgatt ccaaggatca   1286

gcctggatgc ctagaggact agatcacctt agtttgattc tattttttag cttgcaaaaa   1346

gtgacttata ttccaaagaa attaaaatgt tgaaatccaa atcctagaaa taaaatgagt   1406

taacttcaaa catttcagaa aacaaaaaaa aaaa                               1440


<210>  146
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Met Pro Ser Arg Thr Asn Leu Ala Thr Gly Ile Pro Ser Ser Lys 
1               5                   10                  15      


Val Lys Tyr Ser Arg Leu Ser Ser Thr Asp Asp Gly Tyr Ile Asp Leu 
            20                  25                  30          


Gln Phe Lys Lys Thr Pro Pro Lys Ile Pro Tyr Lys Ala Ile Ala Leu 
        35                  40                  45              


Ala Thr Val Leu Phe Leu Ile Gly Ala Phe Leu Ile Ile Ile Gly Ser 
    50                  55                  60                  


Leu Leu Leu Ser Gly Tyr Ile Ser Lys Gly Gly Ala Asp Arg Ala Val 
65                  70                  75                  80  


Pro Val Leu Ile Ile Gly Ile Leu Val Phe Leu Pro Gly Phe Tyr His 
                85                  90                  95      


Leu Arg Ile Ala Tyr Tyr Ala Ser Lys Gly Tyr Arg Ala Tyr Ser Tyr 
            100                 105                 110         


Asp Asp Ile Pro Asp Phe Asp Asp 
        115                 120 


<210>  147
<211>  1263
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (310)..(888)
<223>  

<400>  147
cgctcgctcc cgcaactgga ggcacggcag aggaggcagg gccgacggcg gtgggcggtg     60

cgttgcgcag gctcgggcct cccgctcgcc gctgcgttgg gaccgcgcag cccggtgtgt    120

gcagtggcct cagggatccg gaaagtctag gactgaactt ctcctaacat ccagtaatgg    180

ggacctggaa cctgggcgta ctagagtgcc gcgcgtaggg ctccaggtcg ctggcttctg    240

cgctttcttc ctctccaaag ttgagtatct cctatctgtg tcctcataca tactgccgcc    300

tgaggtgcc atg gcc ccc aag ccg ggg gcc gag tgg agc aca gcc ctg tcc    351
          Met Ala Pro Lys Pro Gly Ala Glu Trp Ser Thr Ala Leu Ser       
          1               5                   10                        

cat ctg gtg ctg gga gtg gtg tct ctg cac gca gcc gtg agc aca gcc      399
His Leu Val Leu Gly Val Val Ser Leu His Ala Ala Val Ser Thr Ala         
15                  20                  25                  30          

gag gca agt cga ggg gct gct gct ggc ttc ctg ctc cag gtc ttg gct      447
Glu Ala Ser Arg Gly Ala Ala Ala Gly Phe Leu Leu Gln Val Leu Ala         
                35                  40                  45              

gcc acc acc acg ctg gcc cca ggg ctg agc aca cat gaa gac tgc ctt      495
Ala Thr Thr Thr Leu Ala Pro Gly Leu Ser Thr His Glu Asp Cys Leu         
            50                  55                  60                  

gct gga gcc tgg gtg gcc acc gtc atc ggc ctt ccc ctt ctg gcc ttc      543
Ala Gly Ala Trp Val Ala Thr Val Ile Gly Leu Pro Leu Leu Ala Phe         
        65                  70                  75                      

gat ttc cac tgg gtg aat ggg gac cgc tcc tct gcc aac ctg ctc ctg      591
Asp Phe His Trp Val Asn Gly Asp Arg Ser Ser Ala Asn Leu Leu Leu         
    80                  85                  90                          

gga gga ggc atg gtg ctg gca gtg gct ggc ggc cac ctc ggc cct gag      639
Gly Gly Gly Met Val Leu Ala Val Ala Gly Gly His Leu Gly Pro Glu         
95                  100                 105                 110         

ggc cgc tct gtg gct ggt cag gca atg ctg ttg gtg gtc gca gtg acc      687
Gly Arg Ser Val Ala Gly Gln Ala Met Leu Leu Val Val Ala Val Thr         
                115                 120                 125             

atc ctc att gta gct gtc ttc acg gcc aac act tat ggg atg tgg ggg      735
Ile Leu Ile Val Ala Val Phe Thr Ala Asn Thr Tyr Gly Met Trp Gly         
            130                 135                 140                 

ggg gcg atg ctg ggt gtg gca ggc ctc ctg agc cgg ctg gag gag gac      783
Gly Ala Met Leu Gly Val Ala Gly Leu Leu Ser Arg Leu Glu Glu Asp         
        145                 150                 155                     

agg ctg ctg ctg cta ccg aag gag gat gtc tgt cgc tgg gcc ttg gct      831
Arg Leu Leu Leu Leu Pro Lys Glu Asp Val Cys Arg Trp Ala Leu Ala         
    160                 165                 170                         

gta ggc agc tgg gct tac tgc cgg gcc ctg cat aca cag cgc ctc cag      879
Val Gly Ser Trp Ala Tyr Cys Arg Ala Leu His Thr Gln Arg Leu Gln         
175                 180                 185                 190         

tgg gag tga cagttggata cagccaggca gggtttctgc cctgccgaac              928
Trp Glu                                                                 
                                                                        

actttccctc ccacctgcct gctcctggcg ccttctccct aggggtagac tcttctgcct    988

actgaagtgg gtttgctgca cattgactgg tcaggggcag agtctgggtg ctgtcctttg   1048

gccacgtgtg gggacttgtc tagaccagaa tgaaagggac agggtcccag acacgtttgg   1108

gggtcctgat tctgggctgg acacggttgt ggatccagag aagaggccta gtctccaata   1168

aatcttagga attttgcagg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1228

aaaaaaaaaa aaaaaaaaaa aaaaaaaccc tgggg                              1263


<210>  148
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Ala Pro Lys Pro Gly Ala Glu Trp Ser Thr Ala Leu Ser His Leu 
1               5                   10                  15      


Val Leu Gly Val Val Ser Leu His Ala Ala Val Ser Thr Ala Glu Ala 
            20                  25                  30          


Ser Arg Gly Ala Ala Ala Gly Phe Leu Leu Gln Val Leu Ala Ala Thr 
        35                  40                  45              


Thr Thr Leu Ala Pro Gly Leu Ser Thr His Glu Asp Cys Leu Ala Gly 
    50                  55                  60                  


Ala Trp Val Ala Thr Val Ile Gly Leu Pro Leu Leu Ala Phe Asp Phe 
65                  70                  75                  80  


His Trp Val Asn Gly Asp Arg Ser Ser Ala Asn Leu Leu Leu Gly Gly 
                85                  90                  95      


Gly Met Val Leu Ala Val Ala Gly Gly His Leu Gly Pro Glu Gly Arg 
            100                 105                 110         


Ser Val Ala Gly Gln Ala Met Leu Leu Val Val Ala Val Thr Ile Leu 
        115                 120                 125             


Ile Val Ala Val Phe Thr Ala Asn Thr Tyr Gly Met Trp Gly Gly Ala 
    130                 135                 140                 


Met Leu Gly Val Ala Gly Leu Leu Ser Arg Leu Glu Glu Asp Arg Leu 
145                 150                 155                 160 


Leu Leu Leu Pro Lys Glu Asp Val Cys Arg Trp Ala Leu Ala Val Gly 
                165                 170                 175     


Ser Trp Ala Tyr Cys Arg Ala Leu His Thr Gln Arg Leu Gln Trp Glu 
            180                 185                 190         


